Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Audrey de JongAnne BignonFrançois StéphanThomas GodetJean-Michel ConstantinKarim AsehnouneAude SylvestreJuliette SautilletRaiko BlondonnetMartine FerrandierePhilippe SeguinSigismond LasockiAmélie RolléPierre-Marie FayolleLaurent MullerEmmanuel PardoNicolas TerziSeverin RaminBoris JungPaër-Sélim AbbackPhilippe GuerciBenjamine SartonHadrien RozéClaire DupuisJoel CoussonMarion FaucherVirginie LemialeBernard CholleyGerald ChanquesFouad BelafiaHelena HuguetEmmanuel FutierÉlie AzoulayNicolas MolinariSamir JaberRoman CalypsoAstrid Bouteau-DurandMichel CarlesHossen MehdaouiBertrand SouweineLaure CalvetMatthieu JabaudonBenjamin RieuClara CandilleFlorian SigaudBeatrice RiuLaurent PapazianSabine ValeraDjamel MokartLaurent Chow ChineMagali BisbalCamille PouliquenJean-Manuel de GuibertMaxime TourretDamien MalletMarc LeoneLaurent ZieleskiewiczJeanne CossicMona AssefiElodie BaronCyril QuemeneurAntoine MonselMatthieu BiaisAlexandre OuattaraEline BonnardelSimon MonziolsMartin MahulJean-Yves LefrantClaire RogerSaber BarbarFabien LambiottePiehr Saint-LegerCatherine PaugamJulien PottecherPierre-Olivier LudesLucie DarrivereMarc GarnierEric KipnisGilles LebuffeMatthias GarotJeremy FalconeBenjamin ChoustermanMagali ColletÉtienne GayatJean DellamonicaWilly-Serge MfamEvelina OchinMohamed NebliNejla TiloucheBenjamin MadeuxDavid BougonYassir AarabFanny Garnier
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [CHU Lille] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hôpital Marie-Lannelongue CHU Clermont-Ferrand CHU Pitié-Salpêtrière [AP-HP] Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Nord [CHU - APHM] Centre Hospitalier de la Polynésie Française CHU Clermont-Ferrand Centre Hospitalier Régional Universitaire de Tours Université de Tours Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Centre Hospitalier Universitaire d'Angers Université d'Angers Centre Hospitalier Universitaire de Pointe-à-Pitre / Les Abymes [Guadeloupe] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre Hospitalier Universitaire de Nîmes Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Beaujon [AP-HP] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Toulouse Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Centre Hospitalier Universitaire de Bordeaux CHU Clermont-Ferrand Hôpital universitaire Robert Debré [Reims] Institut Paoli-Calmettes Hopital Saint-Louis [AP-HP] Hôpital Européen Georges Pompidou [APHP] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Institut Montpelliérain Alexander Grothendieck Centre Hospitalier Régional Universitaire [Montpellier] CHU Clermont-Ferrand Hopital Saint-Louis [AP-HP] Institut Desbrest d'Epidémiologie et de Santé Publique Médecine de précision par intégration de données et inférence causale Institut Montpelliérain Alexander Grothendieck Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Marie-Lannelongue Hôpital l'Archet Laboratoire Microorganismes : Génome et Environnement Service Médecine Intensive et Réanimation [CHU Clermont-Ferrand] CHU Clermont-Ferrand Pôle Médecine Péri-opératoire [CHU Clermont-Ferrand] Génétique, Reproduction et Développement CHU Clermont-Ferrand CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Universitaire de Toulouse Hôpital Nord [CHU - APHM] Centre d'études et de recherche sur les services de santé et la qualité de vie Assistance Publique - Hôpitaux de Marseille Institut Paoli-Calmettes Institut Paoli-Calmettes Département d'anesthésiologie et de soins intensifs [Institut Paoli-Calmettes, Marseille] Université de Rennes - Faculté de Médecine Hôpital Nord [CHU - APHM] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre Hospitalier Régional Universitaire [Montpellier] Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire Service de réanimation médicale polyvalente [CHU Cochin] Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire Department of Anesthesiology, Clinique Drouot Sport, 37 rue Molitor, Paris 75016, France CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Bordeaux Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Université de Bordeaux Université de Bordeaux Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier de Valenciennes Centre hospitalier [Valenciennes, Nord] Hôpital Beaujon [AP-HP] Hôpital de Hautepierre [Strasbourg] Hôpitaux Universitaires de Strasbourg CHU Saint-Antoine [AP-HP] Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 Hôpital Claude Huriez [Lille] Hôpital Claude Huriez [Lille] Marqueurs cardiovasculaires en situation de stress Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière] Marqueurs cardiovasculaires en situation de stress Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière] Fédération Hospitalo-Universitaire PRecision medicine for cOMprehensIve care of Critically ill patiEnts Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire d'Orléans Service de médecine intensive-réanimation Centre Hospitalier de Gonesse Centre Hospitalier de Bigorre [Tarbes] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Hôpital Saint Eloi [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : Background : Non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] or standard oxygen) following extubation have never been compared in critically ill patients with obesity. We aimed to compare NIV (alternating with HFNO or standard oxygen) and oxygen therapy (HFNO or standard oxygen) following extubation of critically ill patients with obesity. Methods : In this multicentre, parallel group, pragmatic randomised controlled trial, conducted in 39 intensive care units in France, critically ill patients with obesity undergoing extubation were randomly assigned (1:1) to either the NIV group or the oxygen therapy group. Two randomisations were performed: first, randomisation to either NIV or oxygen therapy, and second, randomisation to either HFNO or standard oxygen (also 1:1), which was nested within the first randomisation. Blinding of the randomisation was not possible, but the statistician was masked to group assignment. The primary outcome was treatment failure within 3 days after extubation, a composite of reintubation for mechanical ventilation, switch to the other study treatment, or premature discontinuation of study treatment. The primary outcome was analysed by intention to treat. Effect of medical and surgical status was assessed. The reintubation within 3 days was analysed by intention to treat and after a post-hoc crossover analysis. This study is registered with ClinicalTrials.gov number NCT04014920. Findings : From Oct 2, 2019, to July 17, 2021, of the 1650 screened patients, 981 were enrolled. Treatment failure occurred in 66 (13·5%) of 490 patients in the NIV group and in 130 (26·5%) of 491 patients in the oxygen-therapy group (relative risk 0·43; 95% CI 0·31–0·60, p<0·0001). Medical or surgical status did not modify the effect of NIV group on the treatment-failure rate. Reintubation within 3 days after extubation was similar in the non-invasive ventilation group and in the oxygen therapy group in the intention-to-treat analysis (48 (10%) of 490 patients and 59 (12%) of 491 patients, p=0·26) and lower in the NIV group than in the oxygen-therapy group in the post-hoc cross-over (51 (9%) of 560 patients and 56 (13%) of 421 patients, p=0·037) analysis. No severe adverse events were reported. Interpretation : Among critically ill adults with obesity undergoing extubation, the use of NIV was effective to reduce treatment-failure within 3 days. Our results are relevant to clinical practice, supporting the use of NIV after extubation of critically ill patients with obesity. However, most of the difference in the primary outcome was due to patients in the oxygen therapy group switching to NIV, and more evidence is needed to conclude that an NIV strategy leads to improved patient-centred outcomes.

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Fichiers liés : 2023 De jong et al., Effect of non.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Lena DelpechStefano AlbertiKonstantinos AvramidisAline AyreaultTristan BatalJean-Michel BernardFrancis BouqueyIoannis ChelisFrederic ClairetElodie CorbelLouis DoceulFrederic DurandRemi DumontTheo FonghettiGerd GantenbeinPascal GaribaldiGerardo GiruzziTim GoodmanJean-Philippe HoggeStefan IllyJohn JelonnekJianbo JinHeinrich LaquaFrancois LegrandChristophe LievinPhilippe MagaudPatrick MagetPierre ManasStefan MarsenXavier Regal-MezinPatrick MollardDavid MouyonLaurent NicolasAdam OuerfelliIoannis PagonakisBenjamin RobinetTobias RuessBenjamin SantraineManfred ThummZisis Ioannidis
• Organismes : Institut de Recherche sur la Fusion par confinement Magnétique Swiss Plasma Center National and Kapodistrian University of Athens THALES [France] Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique National and Kapodistrian University of Athens Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Swiss Plasma Center Swiss Plasma Center Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Max Planck Institute for Plasma physics THALES [France] THALES [France] Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Max Planck Institute for Plasma physics Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Karlsruhe Institute of Technology = Karlsruher Institut für Technologie
• Publié dans Fusion Engineering and Design le 24/10/2020

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Résumé : Abstract The mission of WEST (tungsten-W Environment in Steady-state Tokamak) is to explore long pulse operation in a full tungsten (W) environment for preparing next-step fusion devices (ITER and DEMO) with a focus on testing the ITER actively cooled W divertor in tokamak conditions. Following the successful completion of phase 1 (2016-2021), phase 2 started in December 2022 with the lower divertor made entirely of actively cooled ITER-grade tungsten mono-blocks. A boronization prior the first plasma attempt allowed for a smooth startup with the new divertor. Despite the reduced operating window due to tungsten, rapid progress has been made in long pulse operation, resulting in discharges with a pulse length of 100 s and an injected energy of around 300 MJ per discharge. Plasma startup studies were carried out with equatorial boron nitride limiters to compare them with tungsten limiters, while Ion Cyclotron Resonance Heating assisted startup was attempted. High fluence operation in attached regime, which was the main thrust of the first campaigns, already showed the progressive build up of deposits and appearance of dust, impacting the plasma operation as the plasma fluence increased. In total, the cumulated injected energy during the first campaigns reached 43 GJ and the cumulated plasma time exceeded 5 h. Demonstration of controlled X-Point Radiator regime is also reported, opening a promising route for investigating plasma exhaust and plasma-wall interaction issues in more detached regime. This paper summarises the lessons learned from the manufacturing and the first operation of the ITER-grade divertor, describing the progress achieved in optimising operation in a full W environment with a focus on long pulse operation and plasma wall interaction.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Maxence ButtardGuilhem MartinXavier BataillonGilles RenouPierre LhuissierJulie VillanovaBéchir ChehabPhilippe JarryJean-Jacques BlandinPatricia Donnadieu
• Organismes : Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés European Synchrotron Radiation Facility [Grenoble] Constellium Technology Center Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés
• Publié dans Additive Manufacturing le 25/10/2020

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Résumé : High-strength aluminium alloys from the 2XXX, 6XXX, and 7XXX series suffer from severe hot cracking issues during 3D printing. Thus, there is a need to design new alloys with an improved hot cracking resistance while taking advantage of the non-equilibrium processing conditions of laser powder bed fusion to achieve optimized properties. Here, we report the successful fabrication of a new Al-Mn-Ni-Cu-Zr alloy designed for L-PBF. The asbuilt microstructure was characterized at different scales using synchrotron X-ray nano-tomography and microscopy with a special focus on automated crystallographic orientation mapping (ACOM) in transmission electron microscopy. Based on this multiscale microstructural investigation, we identify various mechanisms involving the presence of a locally ordered liquid during solidification under conditions typical of additive manufacturing. This local liquid ordering is often defined as Icosahedral Short Range Order (ISRO). The multiple consequences of ISRO in the liquid on the hierarchical microstructure inherited from additive manufacturing are discussed. ISRO enables refinement of the grain size thus improving the processability via an increase of the hot cracking resistance, producing equiaxed grains and twinned dendrites contributing to randomizing the crystallographic texture, and possibly extending supersaturated solid solutions through a cage effect. It is concluded that promoting ISRO should be considered a promising pathway to design alloys for additive manufacturing with good processability and optimized properties.

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Fichiers liés : Final_version.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Hongliang MaXiaojun LiJiangyuan ZengXiang ZhangJianzhi DongNengcheng ChenLei FanMorteza SadeghiFrédéric FrappartXiangzhuo LiuMengjia WangHuan WangZheng FuZanpin XingPhilippe CiaisWigneron J.-P.
• Organismes : Interactions Sol Plante Atmosphère Wuhan University [China] Interactions Sol Plante Atmosphère Aerospace Information Research Institute Aerospace Information Research Institute China University of Geosciences [Wuhan] Massachusetts Institute of Technology Tianjin University Wuhan University [China] China University of Geosciences [Wuhan] Southwest University [Chongqing] California Department of Water Resources Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Chinese Academy of Sciences [Beijing] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Recently, large efforts have been made to develop surface soil moisture (SSM) products based on observations from passive microwave L-band satellites at the global scale. Despite vast previous efforts to assess satellite SSM products based on in situ data, the performance of L-band SSM products remains still little known over the tropical areas including the rainforests. To close this knowledge gap, a comprehensive evaluation of five L-band SSM products from the Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP) satellites, including SMOS-IC, SMAP SCA-V, DCA, and MTDCA, as well as the recently developed SMAP INRAE-BORDEAUX (SMAP-IB) was conducted in tropical areas from 2015 to 2020. The investigation was implemented by using in situ observations, and expanded by the Triple Collocation Analysis (TCA) and double instrumental variable (IVd) methods. The results revealed that all the five L-band SSM products show a good capacity to estimate SSM in most moderately vegetated areas of the tropical areas while they exhibit some uncertainties in dense vegetation (e.g., rainforests). The SSM climatology of the five L-band products in rainforests agreed generally well with that of in situ measurements especially for SMOS-IC (R = 0.75), followed by SMAP-IB (R = 0.72). Notably, the newly developed SMAP-IB shows satisfactory performance in the tropics with the highest R of 0.73 and the smallest unbiased root mean square difference (ubRMSD) of 0.041 m3/m3 from the study based on in situ SM data, and R of >0.81 from the combined TCA/IVd method in most vegetation conditions. SMAP-DCA SSM demonstrates comparable performance to SMAP-SCA-V (R = 0.66) from the in situ based analysis. This study is expected to deepen our understanding on the skill of L-band SSM products in tropical areas and further promote possible upgrades in algorithms and applications in these regions.

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Fichiers liés : 1-s2.0-S0034425722004503-am.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2023
• Auteurs : Michael J O'DonohueMonique AxelosSarah-Louise FilleuxChavance YannLerayer Pierre-YvesAigue VéroniqueJohnny BeaugrandHelene FulcrandPhilippe GerardinJean-Denis MathiasVirginie Vandenbossche Maréchal
• Organismes : Toulouse Biotechnology Institute Département Aliments, produits biosourcés et déchets - INRAE Département Aliments, produits biosourcés et déchets - INRAE Direction de la communication Auteur indépendant Auteur indépendant Auteur indépendant Unité de recherche sur les Biopolymères, Interactions Assemblages Ingénierie des Agro-polymères et Technologies Émergentes Laboratoire d'Etudes et de Recherche sur le Matériau Bois Laboratoire d'ingénierie pour les systèmes complexes Laboratoire de Chimie Agro-Industrielle

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Résumé : La biomasse semble un remède miracle pour réduire nos émissions de gaz à effet de serre et atténuer le changement climatique, particulièrement pour le secteur du bâtiment, responsable de près d’un quart des émissions en France. Construire en bois, paille, tournesol, chanvre répond-il à toutes les questions ?

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Fichiers liés : 2023_O'Donohue_RESSOURCES#3_Chapitre Futurs _Le Biosourcé.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Lisa GoudmanPhilippe RigoardMaxime BillotAnn de SmedtManuel RoulaudDiscover ConsortiumMaarten MoensTom EykensKelly de KeersmaeckerMayken GorissenChrist de ClerckAnn Ver DonckHannie BraemsKlaas BuyseMartine PuylaertWim DuyvendakChris de SmetSteven VissersJohan DebeufKim de BeuckerJeroen CeuppensPieter Jan GermonpréSarah MortierJean Pierre van BuytenIris SmetMarieke DevosDimitri VanhauwaertBart BilletKarel HanssensAnnemarie DemeyereTine CasierBénédicte BertremTony van HavenberghPieter van LooyGertje HeylenCatherine de SchryverJohan VangeneugdenFrédéric LouisVirginie StalmansJean- Michel RemacleThibault RemacleStéphane MauvielLaurence AbeloosTom TheysAnaïs van HoylandtDominike BruyninckxJohn DasIna CallebautPhilippe RigoardManuel RoulaudBertille LorgeouxMats de JaegerAlexis Valenzuela EspinozaRobbert-Jan van Hooff
• Organismes : Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime]
• Publié dans Neuromodulation le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Raphael CinottiAntoine RoquillyAlice ChopinFlorian Pierre MartinYoanna MoratoCéline LerebourgJean-Denis MoyerOlivier HuetSigismond LasockiBenjamin CohenClaire Dahyot-FizelierKévin ChalardPhilippe SeguinAmandine ChenetBrigitte Perrouin-VerbeDebajyoti SinhaKarim AsehnouneFanny FeuilletVéronique Sébille
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis University of Melbourne Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Hôpital Beaujon [AP-HP] Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Centre Hospitalier Universitaire d'Angers Centre Hospitalier Régional Universitaire de Tours Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Gui de Chauliac [CHU Montpellier] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hôpital Saint-Jacques [Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital The Enteric Nervous System in gut and brain disorders [U1235] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch methodS in Patients-centered outcomes and HEalth ResEarch
• Publié dans Annals of Physical and Rehabilitation Medicine le 02/11/2020

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Résumé : No abstract available

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Philippe GaudardHélène DavidPatrice BideauxPierre SicardJean-Paul CristolGilles GuillonSylvain RichardPascal ColsonAnne Virsolvy
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : Acute heart failure (AHF) due to acute myocardial infarction (AMI) is likely to involve cardiogenic shock (CS), with neuro-hormonal activation. A relationship between AHF, CS and vasopressin response is suspected. This study aimed to investigate the implication of vasopressin on hemodynamic parameters and tissue perfusion at the early phase of CS complicating AMI. Experiments were performed on male Wistar rats submitted or not to left coronary artery ligation (AMI and Sham). Six groups were studied Sham and AMI treated or not with either a vasopressin antagonist SR-49059 (Sham-SR, AMI-SR) or agonist terlipressin (Sham-TLP, AMI-TLP). Animals were sacrificed one day after surgery (D1) and after hemodynamic parameters determination. Vascular responses to vasopressin were evaluated, ex vivo, on aorta. AHF was defined by a left ventricular ejection fraction below 40%. CS was defined by AHF plus tissue hypoperfusion evidenced by elevated serum lactate level or low mesenteric oxygen saturation (SmO2) at D1. Mortality rates were 40% in AMI, 0% in AMI-SR and 33% in AMI-TLP. Immediately after surgery, a sharp decrease in SmO2 was observed in all groups. At D1, SmO2 recovered in Sham and in SR-treated animals while it remained low in AMI and further decreased in TLP-treated groups. The incidence of CS among AHF animals was 72% in AMI or AMI-TLP while it was reduced to 25% in AMI-SR. Plasma copeptin level was increased by AMI. Maximal contractile response to vasopressin was decreased in AMI (32%) as in TLP- and SR- treated groups regardless of ligation. Increased vasopressin secretion occurring in the early phase of AMI may be responsible of mesenteric hypoperfusion resulting in tissue hypoxia. Treatment with a vasopressin antagonist enhanced mesenteric perfusion and improve survival. This could be an interesting therapeutic strategy to prevent progression to cardiogenic shock.

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Fichiers liés : 2023 Gaudard et al., Involvement of Vasopressin in.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Quentin RillerJacques FourgeaudJulie BruneauSuk See de RavinGrace SmithMathieu FusaroSamy MeriemAude MagerusMarine LukaGhaith AbdessalemLudovic LhermitteAnne JametEmmanuelle SixAlessandra MagnaniMartin CastelleRomain LévyMathilde LecuitBenjamin FournierSarah WinterMichaela SemeraroGraziella PintoHanène AbidNizar MahlaouiNathalie CheikhBenoit FlorkinPierre FrangeEric JeziorskiFelipe SuarezFrançoise Sarrot-ReynauldDalila NouarDominique DebrayFlorence LacailleCapucine PicardPhilippe PérotBéatrice RegnaultNicolas da RochaCamille de CevinsLaure DelageBrieuc PérotAngélique VinitFrancesco CarboneCamille BrunaudManon MarchaisMarie-Claude StolzenbergVahid AsnafiThierry MolinaFrédéric Rieux-LaucatLuigi NotarangeloStefania PittalugaJean Philippe JaisDespina MoshousStephane BlancheHarry MalechMarc EloitMarina CavazzanaAlain FischerMickaël MénagerBénédicte Neven
• Organismes : Immunogenetics of pediatric autoimmune diseases Hôpital Necker - Enfants Malades [AP-HP] Découverte de pathogènes – Pathogen discovery Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] National Institutes of Health [Bethesda, MD, USA] National Institutes of Health [Bethesda, MD, USA] Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Immunogenetics of pediatric autoimmune diseases Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Institut Necker Enfants-Malades Hôpital Necker - Enfants Malades [AP-HP] Institut Necker Enfants-Malades Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] CIC NECKER BT Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Régional Universitaire de Besançon Hôpital de la Citadelle Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] Université de Montpellier CHU Montpellier = Montpellier University Hospital Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Régional Universitaire de Tours Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Activation lymphocytaire et susceptibilité au virus d’Epstein-Barr = Lymphocyte activation and susceptibility to EBV Découverte de pathogènes – Pathogen discovery Centre Collaborateur de l'OIE de Détection et identification chez l’homme des pathogènes animaux émergents et développement d’outils pour leur diagnostic / Collaborating Center for the Detection and identification in humans of emerging animal pathogens and development of tools for their diagnoses Découverte de pathogènes – Pathogen discovery Centre Collaborateur de l'OIE de Détection et identification chez l’homme des pathogènes animaux émergents et développement d’outils pour leur diagnostic / Collaborating Center for the Detection and identification in humans of emerging animal pathogens and development of tools for their diagnoses Découverte de pathogènes – Pathogen discovery Centre Collaborateur de l'OIE de Détection et identification chez l’homme des pathogènes animaux émergents et développement d’outils pour leur diagnostic / Collaborating Center for the Detection and identification in humans of emerging animal pathogens and development of tools for their diagnoses Inflammatory Responses and Transcriptomic Networks in diseases Sanofi Aventis R&D [Chilly-Mazarin] Immunogenetics of pediatric autoimmune diseases Inflammatory Responses and Transcriptomic Networks in diseases Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé Inflammatory Responses and Transcriptomic Networks in diseases Immunogenetics of pediatric autoimmune diseases Immunogenetics of pediatric autoimmune diseases Immunogenetics of pediatric autoimmune diseases Hôpital Necker - Enfants Malades [AP-HP] Institut Necker Enfants-Malades Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] Immunogenetics of pediatric autoimmune diseases National Institutes of Health [Bethesda, MD, USA] National Institutes of Health [Bethesda, MD, USA] Université Paris Cité Genome dynamics in the immune system Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] National Institutes of Health [Bethesda, MD, USA] Découverte de pathogènes – Pathogen discovery Centre Collaborateur de l'OIE de Détection et identification chez l’homme des pathogènes animaux émergents et développement d’outils pour leur diagnostic / Collaborating Center for the Detection and identification in humans of emerging animal pathogens and development of tools for their diagnoses École nationale vétérinaire d'Alfort Hôpital Necker - Enfants Malades [AP-HP] Human Lymphohematopoiesis Laboratory Hôpital Necker - Enfants Malades [AP-HP] Collège de France Inflammatory Responses and Transcriptomic Networks in diseases Immunogenetics of pediatric autoimmune diseases Hôpital Necker - Enfants Malades [AP-HP]
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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Résumé : Background Allogenic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT) are potentially curative treatments for severe combined immunodeficiency (SCID). Late-onset posttreatment manifestations (such as persistent hepatitis) are not uncommon. Objective We sought to characterize the prevalence and pathophysiology of persistent hepatitis in transplanted SCID patients (SCIDH+) and to evaluate risk factors and treatments. Methods We used various techniques (including pathology assessments, metagenomics, single-cell transcriptomics, and cytometry by time of flight) to perform an in-depth study of different tissues from patients in the SCIDH+ group and corresponding asymptomatic similarly transplanted SCID patients without hepatitis (SCIDH−). Results Eleven patients developed persistent hepatitis (median of 6 years after HSCT or GT). This condition was associated with the chronic detection of enteric viruses (human Aichi virus, norovirus, and sapovirus) in liver and/or stools, which were not found in stools from the SCIDH− group (n = 12). Multiomics analysis identified an expansion of effector memory CD8+ T cells with high type I and II interferon signatures. Hepatitis was associated with absence of myeloablation during conditioning, split chimerism, and defective B-cell function, representing 25% of the 44 patients with SCID having these characteristics. Partially myeloablative retransplantation or GT of patients with this condition (which we have named as “enteric virus infection associated with hepatitis”) led to the reconstitution of T- and B-cell immunity and remission of hepatitis in 5 patients, concomitantly with viral clearance. Conclusions Enteric virus infection associated with hepatitis is related to chronic enteric viral infection and immune dysregulation and is an important risk for transplanted SCID patients with defective B-cell function.

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Fichiers liés : nihms-1915167.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Mireille Elodie TsitokanaPierre-André LafonLaurent PrézeauJean-Philippe PinPhilippe Rondard
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : Treatments for central nervous system diseases with therapeutic antibodies have been increasingly investigated over the last decades, leading to some approved monoclonal antibodies for brain disease therapies. The detection of biomarkers for diagnosis purposes with non-invasive antibody-based imaging approaches has also been explored in brain cancers. However, antibodies generally display a low capability of reaching the brain, as they do not efficiently cross the blood-brain barrier. As an alternative, recent studies have focused on single-domain antibodies (sdAbs) that correspond to the antigen-binding fragment. While some reports indicate that the brain uptake of these small antibodies is still low, the number of studies reporting brain-penetrating sdAbs is increasing. In this review, we provide an overview of methods used to assess or evaluate brain penetration of sdAbs and discuss the pros and cons that could affect the identification of brain-penetrating sdAbs of therapeutic or diagnostic interest.

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Fichiers liés : ijms-24-02632.pdf

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