Philippe JEAN-PIERRE

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• Type de publi. :
• Date de publi. : 26/10/2022
• Auteurs : Mikael CohenOcéane Thomel-RocchiAksel SivaDarin OkudaClarisse Carra DallièreFrançoise Durand-DubiefHélène ZéphirCéline LouapreC. BensaJonathan CironEric ThouvenotBertrand BourreOlivier CasezJérôme de SèzeThibault MoreauJean-Philippe NeauDaniel PelletierOrhun KantarciMelih TutuncuNathalie DeracheCassandre Landes-ChâteauChristine Lebrun-Frénay
• Organismes : Unité de Recherche Clinique Côte d’Azur Unité de Recherche Clinique Côte d’Azur Cerrahpasa Faculty of Medicine University of Texas Southwestern Medical Center [Dallas] Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Lille Neurosciences & Cognition - U 1172 CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Hôpital Fondation Adolphe de Rothschild] Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Institut de Génomique Fonctionnelle CHU Rouen Centre Hospitalier Universitaire [CHU Grenoble] CIC Strasbourg Service de Neurologie [Strasbourg] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Service de neurologie [CHU de Poitiers] University of Southern California Mayo Clinic [Rochester] Cerrahpasa Faculty of Medicine Service de Neurologie [CHU Caen] Unité de Recherche Clinique Côte d’Azur Unité de Recherche Clinique Côte d’Azur

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Résumé : Introduction: Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. However global vaccination hesitancy remains and potential effect of COVID19 vaccination on disease activity needs to be assessed. Objectives: We aimed to evaluate if COVID19 vaccination or infection increased the risk of clinical conversion to multiple sclerosis or evidence of disease activity (EDA) in a cohort of RIS subjects. Methods: This multicentric observational study is based on the RISC cohort. Data regarding COVID19 infection and vaccination has been collected between January 2020 and December 2021. We compared the occurrence of clinical conversion to MS and EDA in patients according to their vaccination status. The same analysis was conducted by comparing patients according to their history of COVID19 infection. Results: 217 subjects with known vaccination status were included (Mean age: 44yrs, F/M sex ratio 2.7). 80% of subjects had a complete vaccination and 20% were incompletely or not vaccinated. Both groups did not differ regarding the main demographical data and known risk factors of conversion to MS. No difference was found concerning clinical conversion to MS in the vaccinated versus unvaccinated group (2.4% versus 2.5%, p = 0.9747). We did not observe any statistical difference regarding the rate of EDA in both groups. 20% of subjects had a history of COVID-19 infection. The rate of clinical conversion to MS in the infected compared to the non-infected group did not show any difference The global conversion rate to MS in the whole RISC cohort in 2021 was 2.64%, which is comparable with the observed rates during the four previous years (5.75%, 2.55%, 4.79%, and 4.85% per year respectively). Conclusions: Our study suggests that COVID19 vaccination does not increase the risk of clinical conversion to MS in RIS subjects and supports that immunization can be safely proposed for these patients.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/10/2022
• Auteurs : David SiniscalcoLaurence PessoniGuillaume VignaudJean-François TassinJean-François BardeauAnne BoussonniereAnne-Sophie CastanetPhilippe LeclèrePierre NickmilderLaurent BillonN. Delorme
• Organismes : Institut des Molécules et Matériaux du Mans Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux Institut de Recherche Dupuy de Lôme Polymères, colloïdes, interfaces Institut des Molécules et Matériaux du Mans Institut des Molécules et Matériaux du Mans Unité de chimie organique moléculaire et macromoléculaire Université de Mons = University of Mons Université de Mons = University of Mons Institut pluridisciplinaire de recherche sur l'environnement et les matériaux Institut des Molécules et Matériaux du Mans

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/10/2022
• Auteurs : Pierre GrimaudFabrice PetitLaurent BoiletFlorian JeanMarie LasgorceixPhilippe ChampagneAnne LerichePascal Laurent
• Organismes : Université Polytechnique Hauts-de-France INSA Institut National des Sciences Appliquées Hauts-de-France Laboratoire de Matériaux Céramiques et de Mathématiques Science des Procédés Céramiques et de Traitements de Surface

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 24/10/2022
• Auteurs : Paule-Annick DavoinePhilippe Garat
• Organismes : Spatio-temporal information systems Statistique pour le Vivant et l’Homme

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• Type de publi. : Article dans une revue
• Date de publi. : 22/10/2022
• Auteurs : Guilherme BaumgartenMorgan MadecDuc-Vinh NguyenLucas WerlingJoris PascalChunchesh Malangi GajendramurthyPhilippe BertaniJean-Pierre DjukicLuc Hebrard
• Organismes : Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
• Publié dans IEEE Transactions on Magnetics le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 21/10/2022
• Auteurs : Marie-Line MaublancJean-François GerardDenis PicotMichel GoulardPhilippe BallonJean-Pierre HamardÉric Bideau
• Organismes : Unité de recherche Comportement et Ecologie de la Faune Sauvage Unité de recherche Comportement et Ecologie de la Faune Sauvage Unité de recherche Comportement et Ecologie de la Faune Sauvage Dynamiques et écologie des paysages agriforestiers Ecosystèmes forestiers Ecosystèmes forestiers Unité de recherche Comportement et Ecologie de la Faune Sauvage
• Publié dans Journal of Sustainable Forestry le 26/10/2020

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Résumé : We conducted a field experiment to evaluate the effectiveness of neighboring vegetation to protect cherry-wood (Prunus avium) saplings against roe deer browsing and rubbing, and determine whether this protection varies according to the attractiveness of–and the physical barrier provided by–a variety of nurse shrubs. Our results show that nurse shrubs may delay roe deer browsing and rubbing on highly attractive cherry-wood saplings, even in a situation of high deer density. The most obstructing shrubs at roe deer knee to shoulder height (Populus x canescens and Cytisus scoparius) appeared to be efficient barriers, whereas the spiny shrub (Elaeagnus angustifolia) did not protect saplings more efficiently than thornless species. Yet, obstruction appeared to be less effective against browsing when the nurse species was itself browsed (Cornus sanguinea and Alnus cordata). Since roe deer may help to reduce plantation cleaning through the control of the shrub layer, especially brambles, we argue that natural methods of protection using surrounding vegetation should represent an economic and sustainable alternative to artificial protection of saplings.

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2022
• Auteurs : Flavienne BruyantRémi AmirauxMarie-Pier AmyotPhilippe ArchambaultLise ArtigueLucas Bardedo de FreitasGuislain BécuSimon BélangerPascaline BourgainAnnick BricaudEtienne BrouardCamille BrunetTonya BurgersDanielle CalebKatrine ChalutHervé ClaustreMarcel BabinVéronique Cornet-BarthauxPierre Vincent CoupelMarine CusaFanny CussetLaeticia DadaglioMarty DavelaarGabriele DeslongchampsCéline DimierJulie DinasquetDany DumontBrent ElseIgor EulaersJoannie FerlandGabrielle FilteauMarie-Hélène ForgetJérôme FortLouis FortierMartí GalíMorgane GallinariSvend-Erik GarbusNicole GarciaCatherine Gérikas RibeiroColline GombaultPriscillia GourvilClémence GoyensCindy GrantPierre-Luc GrondinPascal GuillotSandrine HillionRachel HussherFabien JouxHannah Joy-WarrenGabriel JoyalDavid KieberAugustin LafondJosé LagunasPatrick LajeunesseCatherine LalandeJade LarivièreF. LegallKarine LeblancMathieu LeblancJustine LegrasKeith LevesqueKate-Marie LewisEdouard LeymarieAude LeynaertThomas LinkowskiMartine LizotteAdriana Lopes dos SantosClaudie MarecDominique MarieGuillaume MasséPhilippe MassicotteAtsushi MatsuokaLisa MillerSharif MirshakNathalie MorataBrivaëla MoriceauPhilippe-Israël MorinSimon MorissetAnders MosbechAlfonso MucciGabrielle NadaïChristian NozaisIngrid ObernostererTimothe PaireChristos PanagiotopoulosMarie ParenteauNoémie PelletierMarc PicheralBernard QueguinerPatrick RaimbaultJoséphine RasEric RehmLlúcia Ribot LacostaJean-François RontaniBlanche Saint-BéatJulie SansouletNoé SardetCatherine SchmechtigAntoine SciandraRichard SempereCaroline SévignyJordan ToullecMargot TraginJean-Eric TremblayAnnie-Pier TrottierDaniel VaulotAnda VladoiuLei XueGustavo Yunda-Guarin
• Organismes : Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Takuvik Joint International Laboratory ULAVAL-CNRS LIttoral ENvironnement et Sociétés Institut de la Mer de Villefranche LIttoral ENvironnement et Sociétés Fédération de recherche de Roscoff Station biologique de Roscoff = Roscoff Marine Station Laboratoire d'Océanographie Microbienne Fédération de recherche de Roscoff Station biologique de Roscoff = Roscoff Marine Station Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche
• Publié dans Earth System Science Data le 23/10/2020

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Résumé : Abstract. The Green Edge project was designed to investigate the onset, life and fate of a phytoplankton spring bloom (PSB) in the Arctic Ocean. The lengthening of the ice-free period and the warming of seawater, amongst other factors, have induced major changes in arctic ocean biology over the last decades. Because the PSB is at the base of the Arctic Ocean food chain, it is crucial to understand how changes in the arctic environment will affect it. Green Edge was a large multidisciplinary collaborative project bringing researchers and technicians from 28 different institutions in seven countries, together aiming at understanding these changes and their impacts into the future. The fieldwork for the Green Edge project took place over two years (2015 and 2016) and was carried out from both an ice-camp and a research vessel in the Baffin Bay, canadian arctic. This paper describes the sampling strategy and the data set obtained from the research cruise, which took place aboard the Canadian Coast Guard Ship (CCGS) Amundsen in spring 2016. The dataset is available at https://doi.org/10.17882/59892 (Massicotte et al., 2019a).

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Fichiers liés : Bruyant et al 2022 ESSD HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/10/2022
• Auteurs : Gemma LlauradóBogdan VlachoMatthieu WargnyYue RuanJosep Franch-NadalPere DomingoPierre GourdyPierre-Jean SaulnierSamy HadjadjSarah WildRustam ReaBertrand CariouKamlesh KhuntiDídac MauricioJuan Antonio ArroyoJuan-José ChillarónRosa CorcoyRoberto GüerriManel Mata-CasesEmilio OrtegaMatthieu PichelinMaëva SaignesJeanne SaunierSelma El AndaloussiJoëlle Martin-GauthierEmily RebouilleauTanguy RomanPascale MahotMatthieu PichelinAnne-Laure Fournier-GuillouxNicolas MauduitEdith Bigot- CorbelAnne-Sophie BoureauLaure de DekcerAudrey ErnouldClaire PrimotAnne SeguinMarielle JoliveauSonia PouvreauChloé FournierJeremy ThureauEdith FonteneauPamela HublainCarole AgasseMathilde de KergaradecVincent MinvilleFanny Vardon-BounesGuillaume Martin-BlondelBlandine TramuntMarie-Christine TurninHélène HanaireJean Michel MansuyDidier FabreMarie-Blanche ArhainxLaurent CazalsLaure CombesEmmanuelle LamiBruno MégarbanePierre LeroyJean-François GautierTiphaine Vidal-TrecanJean-Pierre RivelineJean-Louis LaplancheStéphane MoulyLouis PotierRonan RousselMalak TaherYawa AboulekaFetta YakerAurelie CarlierAnne BouttenMarilyne Hallot-FeronFadila MourahCharles ThivoletEmilie BlondMuriel RollandJosep Verdecho MendezMarine AlexandreJulien PottecherEmilie RicherLaurent MeyerFlorina LucaJean-Marc LessingerThibault BahougneBruno GuerciSiham BenzirarCatherine Malaplate-ArmandThierry MattonJulien PoissyKarine FaurePierre FontaineFlorence BaudouxAnne VambergueJean David PekarMarc LambertCécile YelnikAmélie BruandetLaurent PetitDidier NeauVincent RigalleauAnnie BerardAmandine GaliootRemy CoudroyArnaud W. ThilleRené RobertFrance Roblot-CazenaveBlandine RammaertPierre Jean SaulnierXavier PiguelNesrine BenhendaCamille HussonCeline OlivierFlorence TorremochaMathilde FratyMarie Flamen D’assignyAurelie MiotValentin BossardKada KloucheAlain MakinsonAriane SultanJean-Baptiste BonnetVincent FoulongneFlorence GaltierCécile AubronSéverine AnsartVéronique KerlanPascale QuiniouJean- Luc CarreStéphane QuesnotBruno LaviolleCarole SchwebelOlivier EpaulardPierre-Yves BenhamouCécile BétryAnne-Laure BorelSandrine LablancheDorra Derouich-GuergourCatherine DuclosEmmanuel CossonErwan GuyotAurore DeniauPhucthutrang NguyenYves ReznikMichael JoubertStéphane AlloucheLydia GuittetSteven GrangeManuel EtienneGaetan PrevostValéry BrunelJean-Christophe LagierDidier RaoultAnne DutourBénédicte GaboritSandrine BoullluPatrice DarmonAdèle LasbleizMathieu CerinoFanny RomainMarie HoussaysJean-Pierre QuenotLionel PirothBruno VergèsLaurence DuvillardBernard BonnotteAlain MercatVincent Dubée DubéeIngrid AllixPatrice RodienRobin DhersinMaylis LebeaultWojciech TrzepizurJocelyne LoisonAntoine BrangierPierre AsfarPascal ReynierFrançoise LarcherFrançoise JoubaudMarie-Rita AndreuGeoffrey UrbanskiLaurent HubertCédric AnnweilerJean DellamonicaJohan CourjonNicolas ChevalierGiulia ChinettiMagda ChafaiBruno MourvillierFirouze Bani-SadrSarra BarraudBrigitte DelemerPhilippe GilleryPascale LabedadeAmélie ChabrolAlfred PenfornisCatherine PetitCoralie AmadouMaxime AdlerClément DubostPierre-Louis ConanLyse BordierFranck CeppaCyril GarciaMathilde SollierOlivier DupuySophie LaplanceOlivier BilluartMarie Joseph AroulandaFrédérique OlivierFlorence AyonNathalie WilhelmLoic EpelboinNadia SabbahAurelie CharpinPierre SquaraOlivier BelliardClaude DuboisMichel MarreJohann AuchabieRoxane CourtoisThierry DuriezTiphaine MergeyLaura ValleeLaetitia SeguinAbdallah Al-SalamehJ.P. LanoixSandrine Soriot-ThomasAnne-Marie Bourgeois-DescoulsRachel DesailloudNatacha GermainBogdan GaluscaGwenaelle BelletonNesrine MarouaniDelia PalaghiuAmira HammourFernando BerdaguerThimothée KlopfensteinHajer ZayetPatrice WiniszewskiMarie ZanussoPauline GarnierIngrid JulierKarim HamzaouiSophie Marty-GresTarik El SadkiLucile CadotJean-Louis DubostCéline GonfroyCatherine CampinosPascale MartresMarie Pierre CoulhonNicolas AllouMarwa BachirStella HoangCandice KembellecOlivia SuplyFatima KharchaAnne-Claire DevougeAnna Flaus-FurmanukIsabelle MadelineVincent EhingerSophie BastardLoic RaffrayFrederic RenouAude BojarskKarine BorsuAngelique GorlinServane Di BernardoCarole Truong van UtStephane RenaudAntoine VignolesEmilie FochLaurie MasseHubert GrandHelene FerrandChristelle Raffaitin-CardinHadjer ZellaguiCeline Castang-BrachetFrederique BouryAna Alvarez TenaIsabelle MouraPierre KalfonLouis PasteurJuliana DarasteanuLouis PasteurArnaud MonierLouis PasteurPascal FoucaultLouis PasteurAlexandra DepuilleLouis PasteurStéphanie Laugier-RobiollePatrick CaneiroMaud BassoEtienne LargerSamir BouamWahiba BenzenatiLeila Ait BachirCamille Cussac PillegandMarc VasseChristophe MichardNathanaëlle MontanierLuc MillotFrançoise CrepetDanielle RatsimbaKevin BouillerSophie BorotIsabelle BruckertAnnie ClergeotFranck SchilloDorothée VignesMuriel Bourgeon-GhittorilachgarClaire Lambert de CursayStéphane LevanteJean-Charles AuréganAntoine MerletCécile ZaragozaGwénaëlle ArnaultAnne-Gaëlle Le LouppOlivier LesieurMariam Roncato-SaberanDidier GouetRomain LemariHong-An AllanoEmmanuel VivierCaroline ParisetCédric LuytonLucien MarchandFanny DoroszewskiMatthieu PecquetLaurent PerardSylvie Vuillermoz-BlasNicolas KackiPatricia CharrierAmélie Ducet-BoiffardFrançoise Desroys Du RoureOlivier BourronDominique Bonnefont-RousselotSuzanne LarocheFranck PhanAgnès HartemannCyrielle CaussyEmmanuel DisseEmilie BlondClaude GuerinThomas PerpointPhilippe MoulinRégine CartierGeoffroy HaririDorothée ChopinCamille VatierNathalie BourcigauxEmmanuelle ChaigneauSophie Christin-MaitreBruno DonadilleBruno FèveSophie LamotheJulie SarfatiPascal PernetAnne ChambonDelphine DemarsyHugo CampagneFrançoise Latil-PlatMonica BerneMarilyne GrinandMarion TouzetAydrey ZabulonJocelyne CraspagCatherine LedouxCédric ContaretBlandine Janand-DelenneAnaïs GiraudMarie Lou LacriminiJoëlle ArrivieDeborah AncelleCarine GuilloisBénédicte FremyAmina ChaalalGaëlle BarrandeAnne DorangeEglantine RouanetDominique Seret-BegueAudrey SaoudAnne-Marie GuedjNathalie BedosFritz-Line VelayoudomMarie DumasBenoite GondaChristine CoffinStéphanie GibiatMyriam LungoChantal BullyPierre SerusclatStella BullyPatricia CarreJean-Philippe LeberreCarlos ElkhouryMarine ThieuxLaetitia Paradisi-PrieurEmma WilmotSarah WildBen FieldParth NarendranRajiv GandhiSophie HarrisDinesh NagiRobert RyderJim DaviesSteve HarrisOliver FreemanBen MaylorKinga VárnaiGail RoadknightMelissa CulAmy EdwardsSusan GeldingKirun GunganahPyei AungMoulinath BanerjeeAli ChakeraDominique RouseSyed Haris AhmedHo Yee CheungHywel RobertsSusan SealSyed Saah ShahAmir HayatCynthia MohandasHtet Htet AungSu Khant ChelNyan LinKavitia NarulaFurruq QuadriSu Lei YinYin YinAlamin AlkundiAbdelmajid MusaEmma BirbeckCharles BodmerIrene BossmanSathis KumarUmesh DashoraElizabeth ToubiMansoor ZafarVinod PatelAmitha GopinathBelinda AllanRemat KarimDharshana AppuhamillageKhubaib AyoubSophie HarrisCharmaine IlangaratneMaliha IqbalRory MacleanOmar MustafaSusan BaxterMalgorzata AdamusKevin BaynesSiva SivappriyanRyan D’costaDinesh NagiVernon ParfittMazharul IslamSadia NasirGail RoadknightKinga VárnaiSenthil VasanVilashini Arul DevahFoteini KavvouraLina FickenJames GilhamVincent SimpsonNeil WalkerUmaira AzizEfthimia KarraDipesh PatelMiranda RosenthalTracy CurranAngela PaisleyMelissa CullParijat de PMay Thin KhinePari QayyamRobert RyderPriscilla SarkarRajiv GandhiBen FieldJames ClarkVesna HoganLauren JacksonJamie-Leigh WilliamsonR. YounesLucy RobinLydia GrixtiSuann TeeAbilash SathyaEmma WilmotMayank PatelCatherine HolmesWasim HanifSandip GhoshParth NarendranEhtasham AhmadEjaz AhmedMelanie DaviesSteven HartshornKamlesh KhuntiLee SimonsDavid WebbBen MaylorJim DaviesOliver FreemanSteve HarrisAnupam BrahmaSeshadri PramodhKaty FrewAlison MackenzieAbigail WildHelen CaseyDeborah MorrisonConor MckeagAnne SillarsAngus StirlingFiona SmeetonSyed MuhammadKofi ObuobieWin YinNeera AgarwalMike AtkinsonSai AmbatiRahim KhanPreethi NallaArshiya TabasumStamatios ZourasAkhila MallipedhiRichard ChudleighDavid WilliamsMallory CianferaniLisa LudwigCaroline PaulHamoud Lachgar
• Organismes : IMIM-Hospital del Mar Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina Institut de Recerca Sant Pau [Barcelona] = Institut de Recerca de L’hospital de La Santa Creu i de Sant Pau [Barcelona] = Sant Pau Institute for Biomedical Research [Barcelona] Institut du Thorax [CHU Nantes] Centre d’Investigation Clinique de Nantes Oxford Centre for Diabetes, Endocrinology and Metabolism NIHR Oxford Biomedical Research Centre [Oxford, UK] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina Institut Català de la Salut Institut de Recerca Sant Pau [Barcelona] = Institut de Recerca de L’hospital de La Santa Creu i de Sant Pau [Barcelona] = Sant Pau Institute for Biomedical Research [Barcelona] Institut des Maladies Métaboliques et Casdiovasculaires CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Institut du Thorax [CHU Nantes] Usher Institute [Edinburgh] Oxford Centre for Diabetes, Endocrinology and Metabolism NIHR Oxford Biomedical Research Centre [Oxford, UK] Centre d’Investigation Clinique de Nantes University Hospitals of Leicester NHS Trust [Leicester] Pôle Anesthésie Réanimation [CHU de Toulouse] Centre Hospitalier Universitaire de Toulouse Service Maladies infectieuses et tropicales [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Service Diabétologie [CHU Toulouse] Laboratoire Virologie [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] CIC Montpellier Modélisation et Évaluation des données complexes en Santé Publique Centre Hospitalier Universitaire de Toulouse
• Publié dans Cardiovascular Diabetology le 23/10/2020

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Résumé : Background: It is not clear whether pre-existing macrovascular complications (ischemic heart disease, stroke or peripheral artery disease) are associated with health outcomes in people with diabetes mellitus hospitalized for COVID-19. Methods: We conducted cohort studies of adults with pre-existing diabetes hospitalized for COVID-19 infection in the UK, France, and Spain during the early phase of the pandemic (between March 2020-October 2020). Logistic regression models adjusted for demographic factors and other comorbidities were used to determine associations between previous macrovascular disease and relevant clinical outcomes: mortality, intensive care unit (ICU) admission and use of invasive mechanical ventilation (IMV) during the hospitalization. Output from individual logistic regression models for each cohort was combined in a meta-analysis. Results: Complete data were available for 4,106 (60.4%) individuals. Of these, 1,652 (40.2%) had any prior macrovascular disease of whom 28.5% of patients died. Mortality was higher for people with compared to those without previous macrovascular disease (37.7% vs 22.4%). The combined crude odds ratio (OR) for previous macrovascular disease and mortality for all four cohorts was 2.12 (95% CI 1.83-2.45 with an I2 of 60%, reduced after adjustments for age, sex, type of diabetes, hypertension, microvascular disease, ethnicity, and BMI to adjusted OR 1.53 [95% CI 1.29-1.81]) for the three cohorts. Further analysis revealed that ischemic heart disease and cerebrovascular disease were the main contributors of adverse outcomes. However, proportions of people admitted to ICU (adjOR 0.48 [95% CI 0.31-0.75], I2 60%) and the use of IMV during hospitalization (adjOR 0.52 [95% CI 0.40-0.68], I2 37%) were significantly lower for people with previous macrovascular disease. Conclusions: This large multinational study of people with diabetes mellitus hospitalized for COVID-19 demonstrates that previous macrovascular disease is associated with higher mortality and lower proportions admitted to ICU and treated with IMV during hospitalization suggesting selective admission criteria. Our findings highlight the importance correctly assess the prognosis and intensive monitoring in this high-risk group of patients and emphasize the need to design specific public health programs aimed to prevent SARS-CoV-2 infection in this subgroup.

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Fichiers liés : 2022 Llaurado et al., The association.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/10/2022
• Auteurs : Ons El AttiKatia FajerwergAndrey RyzhikovBénédicte LebeauPhilippe MeniniMyrtil L KahnChristian LorberJulie HotPierre Fau
• Organismes : Équipe MICrosystèmes d'Analyse Laboratoire Matériaux et Durabilité des constructions Nanostructures et chimie organométallique (LPCNO) Laboratoire de physique et chimie des nano-objets

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Résumé : Our objective was to explore chemical strategies based on organometallic precursors in organic solvents to yield unprecedented TiO2- or ZnO-decorated SBA-15. We synthesized hybrid materials (TiO2/SBA-15 or ZnO/SBA-15) from various organometallic precursors such as tetrakis(ethylmethylamido) titanium (TEMAT), titanium tris-amidinate (Ti-Amd) and dicyclohexyl zinc (Zn(Cy)2), and under various hydration conditions. In future work, the efficiency of such materials will be assessed under injection of 400 ppb NO.

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• Type de publi. : Article dans une revue
• Date de publi. : 19/10/2022
• Auteurs : Leny MontheilMélody PhilipponJean-Jacques CornéeMarcelle Boudagher-FadelDouwe J.J. van HinsbergenPierre CampsMarco MaffioneFranck AudemardBrechtje BronsKoen J.R. van der LooijPhilippe Munch
• Organismes : Géosciences Montpellier Géosciences Montpellier Géosciences Montpellier Cardiac Unit, Institute of Child Health Universiteit Utrecht / Utrecht University [Utrecht] Géosciences Montpellier Universiteit Utrecht / Utrecht University [Utrecht] Universidad Nacional de San Luis [San Luis] Géosciences Montpellier
• Publié dans Geological Society of America Bulletin le 26/10/2020

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Résumé : Since the acceptance of plate tectonics, the presence of calc-alkaline magmatic rocks has been recognized as evidence of subduction. But under specific geodynamic circumstances, subduction may occur without generating magmas. Here, we investigate the Cenozoic northern Lesser Antilles arc where, from sparsely exposed magmatic records, Eocene−Oligocene and Pliocene magmatic flare-ups and a Miocene lull were postulated. Nevertheless, most of the arc is submarine, so it is challenging to discern lulls and flare-ups from sampling bias. We review the magmatic evidence exposed onshore in the Lesser Antilles and investigate in detail the island of Antigua, which exposes an Eocene to Miocene volcanic sequence and platform carbonate series that coincide with the postulated lull. By combining lithostratigraphic analysis, structural mapping, 40Ar/39Ar geochronology, and biostratigraphy, we refine the magmatic history of the island and date the arrest of extensive arc magmatism at 35 Ma, with minor activity until 27 Ma. No magmatic products are interleaved with the platform sequence until the latest Oligocene, which confirms a lull in northern Lesser Antilles arc magmatism that may have lasted ca. 20 Ma. Flare-up of magmatic activity contributed to crustal thickening and land emersion, whereas magmatic lulls and related thermal cooling induced subsidence/submersion. Thus, we propose that the paleo-(bio)-geographical evolution of the eastern Caribbean region has been partly controlled by magmatic activity. Fault kinematic analysis, along with anisotropy of magnetic susceptibility, suggest that, at the island scale, magmatic arrest is not associated with a change in stress field during the Oligocene. We speculate that slab flattening triggered by progressive curvature played a role in the temporal shutdown of the northern Lesser Antilles arc.

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Fichiers liés : Manuscript Antigua_word final version.pdf

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