Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 21/09/2022
• Auteurs : Adeline PaumierAntoine Asquier-KhatiSonia ThibautThomas CoefficOlivier LemenandStéphanie LarramendyBrice LeclèreJocelyne CaillonDavid BoutoilleGabriel BirgandSophie PoyetGuillaume DelégliseLydie LibierSimon BenzimraDenis LaforestLaurent ClotteauKarine MichezMarie-Jeanne Blanc-GalibyFranck KerdavidBrigitte Coude Du ForestoFrançois MailletHubert BanctelJean LacrozeMarie-Pierre ThibaultEric GrandsirePierre-Yves LéonardJean-Francois CulardAnne HolsteinBeatrice DubetSebastien FougnotBruno GuesnonAnne-Sophie ReinhardJean Philippe RaultBrieuc GestinJerome FleuranceAlisson VrainPhilippe AndorinGéoffroy de GastinesChristine FantinatoVidal PlongNicolas Le MoingEmilie PradierRegis GouarinDidier GrisardStéphanie ArseneElodie JobertCharles VeronGérard PayroAnnie AlleryHelene ValadeDelphine BoraudRemi GebeileElisabeth ParisiFrancoise AlluinCaroline CoulonGuillaume TeissierArnaud FrançoisGilles DefranceGisele GayOlivier DuquesnoyFabienne ArturSylvain MilletPierre MarchenayNorbert DesbiollesMarie Carole PaoliniEugénie MbengaArel DesjardinsChristian Ehret
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service des maladies infectieuses et tropicales [CHU Nantes] Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] MedQual network MedQual network Centre hospitalier de Saint-Nazaire Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] Pôle de santé Publique - PIMESP [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Laboratoire Biolab 33 Floirac UNIROUEN - UFR Santé Laboratoire ATOUTBIO, unité de microbiologie, Nancy F-54000, France
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : IMPORTANCE Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is considered a leading pathogen contributing to the global burden of antimicrobial resistance. OBJECTIVE To better understand factors associated with the heterogeneity of community-acquired ESBL-producing E coli urinary tract infections (UTIs) in France. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study performed from January 1 to December 31, 2021, was based on data collected via PRIMO (Surveillance and Prevention of Antimicrobial Resistance in Primary Care and Nursing Homes), a nationwide clinical laboratory surveillance system in France. Strains of E coli isolated from community urine samples from January 1 to December 31, 2019, from 59 administrative departments of metropolitan France were included. MAIN OUTCOMES AND MEASURES Quasi-Poisson regression models were used to assess the associations between several ecological factors available on government and administration websites between 2010 and 2020 (demographic population structure, living conditions, baseline health care services, antibiotic consumptions, economic indicators, animal farming density, and environmental characteristics) and the number of ESBL-producing E coli strains isolated from urine samples of individuals with community-acquired UTI in 2019.

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Fichiers liés : paumier_2022_oi_220931_1663173096.81259.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/09/2022
• Auteurs : Benoît PardoenFrédéric CollinPierre BésuelleRobert CharlierJean TalandierS. Dal PontPhilippe CosenzaAbraham van den EijndenJacques Desrues
• Organismes : Laboratoire de Tribologie et Dynamique des Systèmes Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich GéoMécanique Laboratoire sols, solides, structures - risques [Grenoble] Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Agence Nationale pour la Gestion des Déchets Radioactifs GéoMécanique Laboratoire sols, solides, structures - risques [Grenoble] Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Delft University of Technology GéoMécanique Laboratoire sols, solides, structures - risques [Grenoble]

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Résumé : In the context of underground exploitation, the behaviour of rocks near galleries and tunnels conditions their stability. Underground drilling generates deformations, damage, fracturing, and significant modification of flow characteristics in the surrounding rock. However, the influence of small-scale characteristics and behaviour on the rock deformations and damage at engineering scale remains a complex issue. Consequently, the multiscale behaviour of a clay rock is modelled starting from the large scale of the excavation damaged zone around galleries and then enriching the approach by considering microstructural characteristics from the scale of mineral inclusions. Lastly, a double-scale numerical framework is considered. It allows to relate small- to large-scale rock behaviour in terms of deformations and material rupture. In fact, the development of damage and cracking at microscale allows to predict large-scale fracturing. The developed method focuses on a claystone in the particular context of long-term management of high-level nuclear wastes by deep geological repository. The results highlight the possibilities of double-scale computing in the prediction of the behaviour of underground engineering structures.

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Fichiers liés : e3sconf_icegt2020_10003.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/09/2022
• Auteurs : Yasmina KahoulCharlène CarneyJessica MontaigneEmilie CaronAntonino BongiovanniFrédérik OgerEmmanuelle DurandPhillippe FroguelAmelie BonnefondJean-Sébastien AnnicotteChristophe Breton
• Organismes : Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Imperial College London Hammersmith Hospital NHS Imperial College Healthcare Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283

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Résumé : Background: Deregulation of energy balance during obesity is associated with the development of metabolic diseases such as type 2 diabetes (T2D). Genetic association studies have established the tumor suppressor locus CDKN2A (cyclin dependent kinase inhibitor 2a) as a risk factor associated with T2D. Consistently, CDKN2A expression in adipose tissue of obese patients is increased. Overall, this locus has a dual function in the regulation of the cell cycle and energy metabolism. We previously showed that Cdkn2a-/- mice exhibit increased energy expenditure via browning of inguinal white adipose tissue (WAT) and improved insulin sensitivity following obesity induced by a high-fat diet (DIO). Goal of the study: To assess whether beiging is cell-autonomously controlled by Cdkn2a and due to transdifferentiation of mature adipocyte and/or recruitment of adipocyte precursors, we analyzed the effect of Cdkn2a deficiency restricted to mature adipocytes in mice (Cdkn2aad-/-). Material et methods: Metabolic studies were performed on mice under chow diet and DIO. Metabolic, hormonal, histological parameters as well as glucose homeostasis were assessed. Histological studies of adipose tissues were also performed. The adipose tissue transcriptome was analyzed by RNA-sequencing. Results: Although metabolic parameters were comparable between controls and mutant animals in chow diet, metabolic, hormonal, histological parameters as well as glucose homeostasis were different in Cdkn2aad-/- DIO mice compared to control littermates. Despite normal food intake, body and fat pad weights, Cdkn2aad-/- DIO mice displayed an improved metabolic profile associated to increased energy expenditure (p<0.01) and improved glucose tolerance (p<0.05) without any changes in insulin sensitivity. Mice also exhibited reduced circulating levels of leptin and resistin (p<0.05). Histological analysis revealed epididymal WAT hypertrophy and inguinal WAT hypoplasia (p<0.05) without effects on proliferation or browning. Transcriptomic analysis of epididymal WAT showed a global increase in metabolic pathways involved in energy substrate utilization, especially glucose metabolism. In particular, a decrease in p70S6K signaling pathway (-log(p-value) 5.540), which is known to reduce insulin signaling, suggests a better use of glucose in Cdkn2a-deficient adipocytes. Conclusion: In summary, these results suggest that the deletion of Cdkn2a in fully differentiated adipocytes is not sufficient to induced WAT browning. Our data provide evidence that the Cdkn2a locus plays a key role in energy metabolism in mature adipocytes, making this gene a good candidate to alleviate the effects of obesity and prevent insulin resistance and T2D.

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• Type de publi. : Article dans une revue
• Date de publi. : 19/09/2022
• Auteurs : Cristina HobeanuPhilippa C. LavalléeHugo CharlesJulien LabreucheGregory W. AlbersLouis R. CaplanGeoffrey A. DonnanJosé M. FerroMichael G. HennericiCarlos A. MolinaPeter M. RothwellPhilippe Gabriel StegPierre Jean TouboulShinichiro UchiyamaÉric VicautK. S. Lawrence WongPierre Amarenco
• Organismes : AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Stanford Medicine Harvard Medical School [Boston] University of Melbourne Universidade de Lisboa = University of Lisbon = Université de Lisbonne [Lisboa] Universität Heidelberg [Heidelberg] = Heidelberg University Vall d'Hebron University Hospital [Barcelona] University of Oxford Imperial College London AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Tokyo Medical University Département de Biostatistiques [Paris] The University of Hong Kong AP-HP - Hôpital Bichat - Claude Bernard [Paris]
• Publié dans The Lancet Neurology le 27/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/09/2022
• Auteurs : Christophe LucchesiJulien LegendrePierre-Olivier ChapuisMathieu ThomasMaud PiquerasDilek CakirogluJean-Philippe PerezÉric TournierRodolphe Vaillon
• Organismes : Centre d'Energétique et de Thermique de Lyon Centre d'Energétique et de Thermique de Lyon Centre d'Energétique et de Thermique de Lyon Centre d'Energétique et de Thermique de Lyon Centre d'Energétique et de Thermique de Lyon Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Énergie Matériaux Fiabilité et Systèmes en Environnements Contraints Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Institut d’Electronique et des Systèmes Micro électronique, Composants, Systèmes, Efficacité Energétique

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• Type de publi. :
• Date de publi. : 19/09/2022
• Auteurs : Myriam MorenoJean-Marc LimousinGuillaume SimioniJulien RuffaultElena OrmeñoJesús Rodríguez-CalcerradaJean-Marc OurcivalJose Manuel Torres RuizHervé CochardJean-Luc DupuyFrançois PimontCatherine FernandezJean-Philippe OrtsAméli TournantPierre-Jean DumasSylvain DelzonNicolas Martin-StPaul
• Organismes : Ecologie des Forêts Méditerranéennes Centre d’Ecologie Fonctionnelle et Evolutive Ecologie des Forêts Méditerranéennes Institut méditerranéen de biodiversité et d'écologie marine et continentale Institut méditerranéen de biodiversité et d'écologie marine et continentale Universidad Politécnica de Madrid Ecologie Systématique et Evolution Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Ecologie des Forêts Méditerranéennes Ecologie des Forêts Méditerranéennes Institut méditerranéen de biodiversité et d'écologie marine et continentale Aix Marseille Université Ecologie des Forêts Méditerranéennes Ecologie des Forêts Méditerranéennes Biodiversité, Gènes & Communautés Ecologie des Forêts Méditerranéennes

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• Type de publi. :
• Date de publi. : 16/09/2022
• Auteurs : Pierre-Yves GomezJean-Philippe Denis
• Organismes : EMLyon Business School Université Paris-Saclay Réseaux Innovation Territoires et Mondialisation

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Résumé : Xerfi Canal a reçu Pierre-Yves Gomez, professeur, IFGE, em lyon business school, pour parler du capitalisme. Une interview menée par Jean-Philippe Denis.

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Fichiers liés : Le_capitalisme_critique_et_resilience_Pierre_Yves_Gomez_.mp4

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• Type de publi. : Communication dans un congrès
• Date de publi. : 14/09/2022
• Auteurs : Pierre GrimaudFabrice PetitLaurent BoiletMarie LasgorceixFlorian JeanAnne LerichePascal LaurentShaan ChamaryPhilippe Champagne
• Organismes : Université Polytechnique Hauts-de-France INSA Institut National des Sciences Appliquées Hauts-de-France Laboratoire de Matériaux Céramiques et de Mathématiques Science des Procédés Céramiques et de Traitements de Surface

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Résumé : The “gel casting” is a process used for producing parts with complex geometries. It was initially developed to overcome the limitations of other shaping processes such as injection moulding or machining. Designed by Janney & Omatete [1] in 1991, this process is very versatile, both in terms of its compatibility with different classes of materials (ceramics and metals) and its compatibility with different mould manufacturing techniques. In practice, gel casting is based on the production of a slurry in an aqueous medium in the presence of a dispersant and a gelling agent. The suspension is pouring into a mould where the gelling can occur and form a three-dimensional network which ensures the conservation of the different parameters of the slurry. The desired part is obtained after drying and then demolding while a debinding/sintering heat treatment ensures its densification. Although the approach is productive and efficient for high quality complexes object, but is it still limited by the need for a manufacturing technic for the mould. Its use is also limited by the toxicity of polymers gelling systems based on acrylamide. The idea for this project is therefore to work on an indirect additive manufacturing process combining stereolithography (SLA) polymer and gel casting. Additive manufacturing allows the manufacture of casting moulds while gel casting allows the shaping of ceramic parts. The coupling of these two techniques theoretically allows the manufacture of parts with very complex shape where only the ability to unmould and dry the sample is a hurdle. [1] Omatete, Ogbemi O., Mark A. Janney, et Stephen D. Nunn. « Gelcasting: From Laboratory Development toward Industrial Production ». Journal of the European Ceramic Society 17, no 2‑3 (january 1997): 407‑13.

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• Type de publi. : Article dans une revue
• Date de publi. : 12/09/2022
• Auteurs : Léo PlaçaisStéphane DalleOlivier DereureSabiha TrabelsiSophie DalacDelphine LegoupilHenri MontaudiéJean Philippe ArnaultJulie de QuatrebarbesPhilippe SaiagFlorence Brunet-PossentiThierry LesimpleEve MaubecFrançois AubinFlorence Granel-BrocardJean-Jacques GrobPierre-Emmanuel StoebnerClara AllayousBastien OrianoCaroline DutriauxLaurent MortierCeleste Lebbé
• Organismes : Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre Hospitalier Régional Universitaire [Montpellier] Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Universitaire [CHU Grenoble] Service de Dermatologie (CHU de Dijon) Centre Hospitalier Régional Universitaire de Brest Service de Dermatologie [Nice] Centre méditerranéen de médecine moléculaire CHU Amiens-Picardie Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Hôpital Ambroise Paré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines AP-HP - Hôpital Bichat - Claude Bernard [Paris] CRLCC Eugène Marquis Hôpital Avicenne [AP-HP] Université Paris 13 Centre Hospitalier Régional Universitaire de Besançon Service de Dermatologie et Allergologie [CHRU Nancy] Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM] Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Recherche en Cancérologie de Montpellier Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie Hopital Saint-Louis [AP-HP] Hôpital Hôtel-Dieu [Paris] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Régional Universitaire [CHU Lille] Service de Dermatologie [AP-HP Hôpital Saint-Louis]
• Publié dans Annals of the Rheumatic Diseases le 26/10/2020

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Résumé : Objective To quantify the risk of immune-related adverse events (irAEs) in patients with pre-existing autoimmune disease (pAID) treated by immune checkpoint inhibitors (ICIs) for stage III or IV melanoma. Methods Case–control study performed on a French multicentric prospective cohort of patients with melanoma, matched for irAE risk factors and oncological staging. Risk of irAE was assessed by logistic regression. Results 110 patients with pAID were included and matched with 330 controls, from March 2013 to October 2020. Over a median follow-up period of 7.2 months for cases and 6.9 months for controls, the ORs of developing all-grade and grade ≥3 irAEs among cases compared with controls were 1.91 (95% CI (1.56 to 2.27)) and 1.44 (95% CI (1.08 to 1.82)), respectively. Patients with pAID had an increased risk of multiple irAEs (OR 1.46, 95% CI (1.15 to 2.67)) and a shorter time to irAE onset. In contrast, there were no difference in irAE-related mortality nor in the rate of treatment discontinuation, and a landmark analysis revealed a better survival at 24 months among cases (p=0.02). Thirty per cent of cases experienced a pAID flare during follow-up, and baseline immunosuppression did not prevent irAE occurrence. Last, we report associations between the pAID clinical subsets and organ-specific irAEs. Conclusion In our study, patients with pAID were at greater risk of all-grade, severe and multiple irAEs, yet had a better 24-month survival than controls. Thus, patients with pAID should be eligible for ICI therapy but benefit from a close monitoring for irAE occurrence, especially during the first months of therapy.

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Fichiers liés : 1445.full.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 10/09/2022
• Auteurs : Philippe DebaekeJean-Noël AubertotMarion BardyPatrick BertuzziJulie ConstantinPatrick DurandLaurence GuichardCatherine MignoletNicolas Munier-JolainOlivier TherondWigneron J.-P.Rémy BallotPierre CellierEric JustesFrédéric HuardChristine Le BasGuy Richard
• Organismes : AGroécologie, Innovations, teRritoires AGroécologie, Innovations, teRritoires InfoSol Agroclim AGroécologie, Innovations, teRritoires Sol Agro et hydrosystème Spatialisation Agronomie Agro-Systèmes Territoires Ressources Mirecourt Agroécologie [Dijon] Laboratoire Agronomie et Environnement - Antenne Colmar Interactions Sol Plante Atmosphère Agronomie Ecologie fonctionnelle et écotoxicologie des agroécosystèmes Département Performances des systèmes de production et de transformation tropicaux Cirad Direction Générale AGroécologie, Innovations, teRritoires Agroclim InfoSol Direction de l'Expertise scientifique collective, de la Prospective et des Etudes

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Résumé : This chapter addresses collection and integration of large amounts of data from a variety of sources when developing agronomic approaches at the landscape and territory levels. Data commonly used in agro-environmental studies are climate, soils, land cover and land use (including cropping practices). They are used as inputs for indicator- or model-based assessment methods. Additional information is now required for agroecological studies, such as spatial distribution of weeds, pests, and diseases; biodiversity; or landscape features. Gathering and using this scattered and heterogeneous information for integrated studies at watershed, regional, or national levels still requires further methodological efforts. Remote sensing is a source of data that continuously progresses in spatial and temporal resolution, and accessibility. Such integrative approaches are illustrated for a case study in France. The next challenges and opportunities for data collection, integration, and governance are discussed, with a focus on mainland France.

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Fichiers liés : Debaeke_etal2022.pdf

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