Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Amira Al RaaisiKévin PrematEvelyne CormierEimad ShotarMehdi DrirVéronique MorelJean-Philippe SpanoHugues Pascal-MousselardLaetitia MorardetFrédéric ClarençonJacques Chiras
• Organismes : Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans European Radiology le 23/10/2020

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Résumé : Objectives Pelvic bone pathological lesions and traumatic fractures are a considerable source of pain and disability. In this study, we sought to evaluate the effectiveness of reinforced cementoplasty (RC) in painful and unstable lesions involving the pelvic bone in terms of pain relief and functional recovery. Methods All patients with neoplastic lesion or pelvic fracture for whom a pelvic bone RC was carried out between November 2013 and October 2017 were included in our study. All patients who failed the medical management, patients unsuitable for surgery, and patients with unstable osteolytic lesions were eligible to RC. Clinical outcome was evaluated with a 1-month and 6month post-procedure follow-up. The primary endpoint was local pain relief measured by the visual analogue scale (VAS). Results Twenty-two patients (18 females, 4 males; mean age of 65.4 ± 13.3 years [range 38-80]) presenting with painful and unstable pelvic lesions were treated by RC during the study period. Among the 22 patients, 8 patients presented with unstable pelvic fractures (3 patients with iliac crest fracture, 3 with sacral fractures, and the remaining 2 with peri-acetabular fractures). No procedure-related complications were recorded. All patients had significant pain relief and functional improvement at 1 month. One patient (4.5%) had suffered a secondary fracture due to local tumour progression. Conclusions Reinforced cementoplasty is an original minimally invasive technique that may help in providing pain relief and effective bone stability for neoplastic and traumatic lesions involving the pelvic bone. Key Points • Reinforced cementoplasty is feasible in both traumatic fractures and tumoural bone lesions of the pelvis. • Reinforced cementoplasty for pelvic bone lesions provides pain relief and functional recovery. • Recurrence of pelvic bone fracture was observed in 4.5% of the cases in our series.

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Fichiers liés : Reinforced cementoplasty for pelvic tumour lesions and pelvic traumatic fractures preliminary experience..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Laure Peter-DerexFrédéric PhilippeauPierre GarnierNathalie André-ObadiaSébastien BoulogneHélène CatenoixPhilippe ConversLaure MazzolaMichel GouttardMaud EstebanJulia FontaineLaura MechtouffElodie OngTae-Hee ChoNorbert NighoghossianNathalie PerretonAnne TermozJulie HaesebaertAnne-Marie SchottMuriel RabilloudChristine PivotCarole DhelensAndrea FilipYves BerthezèneSylvain RheimsFlorent BoutitieLaurent Derex
• Organismes : Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Hôpital de la Croix-Rousse [CHU - HCL] Centre Hospitalier Fleyriat [Bourg en Bresse] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Fleyriat [Bourg en Bresse] Hospices Civils de Lyon Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Research on Healthcare Performance Research on Healthcare Performance Research on Healthcare Performance Research on Healthcare Performance Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Modeling & analysis for medical imaging and Diagnosis Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Research on Healthcare Performance
• Publié dans The Lancet Neurology le 27/10/2020

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Résumé : BACKGROUND: The incidence of early seizures (occurring within 7 days of stroke onset) after intracerebral haemorrhage reaches 30% when subclinical seizures are diagnosed by continuous EEG. Early seizures might be associated with haematoma expansion and worse neurological outcomes. Current guidelines do not recommend prophylactic antiseizure treatment in this setting. We aimed to assess whether prophylactic levetiracetam would reduce the risk of acute seizures in patients with intracerebral haemorrhage. METHODS: The double-blind, randomised, placebo-controlled, phase 3 PEACH trial was conducted at three stroke units in France. Patients (aged 18 years or older) who presented with a non-traumatic intracerebral haemorrhage within 24 h after onset were randomly assigned (1:1) to levetiracetam (intravenous 500 mg every 12 h) or matching placebo. Randomisation was done with a web-based system and stratified by centre and National Institutes of Health Stroke Scale (NIHSS) score at baseline. Treatment was continued for 6 weeks. Continuous EEG was started within 24 h after inclusion and recorded over 48 h. The primary endpoint was the occurrence of at least one clinical seizure within 72 h of inclusion or at least one electrographic seizure recorded on continuous EEG, analysed in the modified intention-to-treat population, which comprised all patients who were randomly assigned to treatment and who had a continuous EEG performed. This trial was registered at ClinicalTrials.gov, NCT02631759, and is now closed. Recruitment was prematurely stopped after 48% of the recruitment target was reached due to a low recruitment rate and cessation of funding. FINDINGS: Between June 1, 2017, and April 14, 2020, 50 patients with mild-to-moderate severity intracerebral haemorrhage were included: 24 were assigned to levetiracetam and 26 to placebo. During the first 72 h, a clinical or electrographic seizure was observed in three (16%) of 19 patients in the levetiracetam group versus ten (43%) of 23 patients in the placebo group (odds ratio 0·16, 95% CI 0·03-0·94, p=0·043). All seizures in the first 72 h were electrographic seizures only. No difference in depression or anxiety reporting was observed between the groups at 1 month or 3 months. Depression was recorded in three (13%) patients who received levetiracetam versus four (15%) patients who received placebo, and anxiety was reported for two (8%) patients versus one (4%) patient. The most common treatment-emergent adverse events in the levetiracetam group versus the placebo group were headache (nine [39%] vs six [24%]), pain (three [13%] vs ten [40%]), and falls (seven [30%] vs four [16%]). The most frequent serious adverse events were neurological deterioration due to the intracerebral haemorrhage (one [4%] vs four [16%]) and severe pneumonia (two [9%] vs two [8%]). No treatment-related death was reported in either group. INTERPRETATION: Levetiracetam might be effective in preventing acute seizures in intracerebral haemorrhage. Larger studies are needed to determine whether seizure prophylaxis improves functional outcome in patients with intracerebral haemorrhage. FUNDING: French Ministry of Health.

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Fichiers liés : 1-s2.0-S1474442222002356-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Lucas GuilloAurelien AmiotMélanie SerreroRomain AltweggXavier RoblinCalina AtanasiuAnthony BuissonCatherine Le BerreCatherine ReenaersJean-Marc GornetDavid LaharieVered AbitbolAmélie BironBénédicte CaronStéphane NanceyAntoine ChupinAntoine BlainLucine VuittonLudovic CailloJulien KirchgesnerMaria NachuryLaurent Peyrin‐BirouletBenjamin ParienteLaurent BeaugeriePhillipe SeksikAnne BourrierArnaud BourrreilleAriadne DesjeuxGuillaume SavoyeStéphanie AuzouGuillaume CadiotAlban BenezechNicolas MathieuGeorgia MalamutKarine AmouriauxHédia BrixiMarion SimonDaniel BenitahPhilippe Ah-SouneMathurin FumeryGilles BoschettiClaire GayMathias VidonGinette FotsingBenoit CoffinCyrielle GillettaJean Marie ReimundMarie Bonnet-Dodel
• Organismes : Hôpital Nord [CHU - APHM] Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375) Service de gastro-entérologie [Henri Mondor AP-HP, Créteil] Hôpital Nord [CHU - APHM] Centre Hospitalier Régional Universitaire [Montpellier] Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne] Centre International de Recherche en Infectiologie Centre hospitalier Saint-Joseph [Paris] Service Hépato-Gastro-Entérologie [CHU Clermont-Ferrand] Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut des Maladies de l'Appareil Digestif Centre Hospitalier Universitaire de Liège Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Bordeaux Service de Gastro-entérologie [CHU Cochin] Hôpital universitaire Robert Debré [Reims] Hôpital de Hautepierre [Strasbourg] Interface de Recherche Fondamentale et Appliquée en Cancérologie Centre International de Recherche en Infectiologie Centre Hospitalier Lyon Sud [CHU - HCL] Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre] Université Paris-Saclay Institut Mutualiste de Montsouris Service de Gastro-Entérologie [CHRU Besançon] Centre Hospitalier Universitaire de Nîmes Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Institute for Translational Research in Inflammation - U 1286 Nutrition-Génétique et Exposition aux Risques Environnementaux Service d'Hépato-gastro-entérologie [CHRU Nancy] Autophagie infection et immunité - Autophagy Infection Immunity [CIRI] Centre Hospitalier Lyon Sud [CHU - HCL]
• Publié dans Digestive Diseases and Sciences le 01/11/2020

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Résumé : Background and aims: Patients with inflammatory bowel disease have an increased risk of venous thromboembolism (VTE) and cardiovascular disease (CVD). The study aims to determine the prevalence of CVD and VTE risk factors in a large population of patients with ulcerative colitis (UC). Methods: We conducted a cross-sectional study in 33 French and Belgium referral centers. A questionnaire was developed to explore self-reported risk factors for VTE and CVD, based on the latest international guidelines, in consecutive patients with UC. Results: A total of 1071 patients with UC were included. There were 539 women (50.3%), and the median age of patients was 44 years [32; 57]. The median disease duration was 10 years [6; 17]. In the cohort, 36.5% of patients reported no cardiovascular risk factor (CVRF) and 72% had ≤ 1 CVRF. Regarding cardiovascular risk markers (CVRM) 36.9% of patients reported no CVRM and 78% had ≤ 1 CVRM. Of the 1071 patients, 91.3% of patients reported no VTE strong risk factor and 96% had ≤ 1 VTE moderate risk factor. Conclusion: This is the first cohort specifically designed to assess both VTE and CVD risks in patients with UC. More than one third of patients with UC had no CVRF and around three quarters had ≤ 1 CVRF. In addition, more than nine out of ten patients had no VTE strong risk factor and ≤ 1 moderate risk factor. Physicians should be aware of these factors in their patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Thomas BittarPierre CarpentierJean-Philippe ChancelierJéro͂me Lonchampt
• Organismes : Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique Performance, Risque Industriel, Surveillance pour la Maintenance et l’Exploitation Optimisation et commande Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique
• Publié dans SIAM Journal on Optimization le 22/10/2020

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Résumé : The stochastic Auxiliary Problem Principle (APP) algorithm is a general Stochastic Approximation (SA) scheme that turns the resolution of an original optimization problem into the iterative resolution of a sequence of auxiliary problems. This framework has been introduced to design decomposition-coordination schemes but also encompasses many well-known SA algorithms such as stochastic gradient descent or stochastic mirror descent. We study the stochastic APP in the case where the iterates lie in a Banach space and we consider an additive error on the computation of the subgradient of the objective. In order to derive convergence results or efficiency estimates for a SA scheme, the iterates must be random variables. This is why we prove the measurability of the iterates of the stochastic APP algorithm. Then, we extend convergence results from the Hilbert space case to the Banach space case. Finally, we derive efficiency estimates for the function values taken at the averaged sequence of iterates or at the last iterate, the latter being obtained by adapting the concept of modified Fejér monotonicity to our framework.

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Fichiers liés : preprint_paper_ppa_v4.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Yuanwei QinXiangming XiaoWigneron J.-P.Philippe CiaisJ. CanadellMartin BrandtXiaojun LiSassan S SaatchiXiaocui WuHao TangRalph DubayahRussell DoughtySean CrowellJingxia ZhaoBerrien Moore
• Organismes : University of Oklahoma University of Oklahoma Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Commonwealth Scientific and Industrial Research Organisation [Australia] University of Copenhagen = Københavns Universitet Interactions Sol Plante Atmosphère Southwest University [Chongqing] University of Illinois at Urbana-Champaign [Urbana] National University of Singapore University of Maryland [College Park] California Institute of Technology University of Oklahoma Tsinghua Shenzhen International Graduate School [Shenzhen] University of Oklahoma
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Australia experienced multi-year drought and record high temperatures, and massive forest fires occurred across the southeast in 2019 and early 2020. In the fire-affected forest areas, understory and often tree canopies were burned, and in-situ observations in late 2020 reported rapid vegetation recovery, including grasses, shrubs, and tree canopies from burned-but-not-dead eucalyptus trees. Considering the strong fire resilience and resistance of eucalyptus trees and above-average rainfall in 2020, we assessed how much and how quickly vegetation structure and biomass changed from loss to post-fire and drought recovery in 2020 for all forest areas in Australia. Here, we analyzed space-borne optical, thermal, and microwave images to assess changes in the structure and function of vegetation using four vegetation indices (VIs), leaf area index (LAI), solar-induced chlorophyll fluorescence (SIF), gross primary production (GPP), and aboveground biomass (AGB). We found that all eight variables show large losses in 2019, driven by fires and climate (drought and high temperature), but large gains in 2020, resulting from the high resilience of most trees to fire and rapid growth of understory vegetation under wet condition in 2020. In 2019, the forest area has an AGB loss of 0.20 Pg C, which is ~15% of the pre-fire AGB. Attribution analyses showed that both fire and climate (prior and co-occurring severe drought and record high temperatures) are responsible for the AGB loss in 2019, approximately 0.09 Pg C (fire) and 0.11 Pg C (climate), respectively. In 2020, the forest area has a total AGB gain of 0.26 Pg C, composed of 0.22 Pg C from fire-affected forest area and 0.04 Pg C from fire-unaffected forest area. Fire-adapted Eucalyptus forests and above-average annual precipitation in 2020 brought by a moderate La Niña drove the recovery of vegetation cover, productivity, and AGB. The results from this study shows the potential of multiple sensors for monitoring and assessing the impacts of fire and climate on the forest areas in Australia and their post-fire recovery.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Garance Diallo-HornezRoman Hossein KhonsariJacques-Marie MercierJean DelaireSophie BalandierVirginie DefayBertrand IsidorGabriel RousteauJean-Claude TalmantJean-Philippe PerrinHélios BertinPierre Corre
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Journal of Stomatology, Oral and Maxillofacial Surgery le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Federico AngrimanBruno FerreyroNatalia AngeloniBruno da CostaRon WaldSean BagshawNeill K.J. AdhikariSean BagshawRon WaldNeill K.J. AdhikariRinaldo BellomoDidier DreyfussBin DuMartin GallagherStéphane GaudryFrançois LamontagneMichael JoannidisKathleen LiuDaniel McauleyShay McguinnessAlistair NicholMarlies OstermannPaul PalevskyHaibo QiuVille PettiläAntoine SchneiderOrla SmithSuvi VaaraMatthew WeirRinaldo BellomoGlenn EastwoodLeah PeckHelen YoungPeter KrugerGordon LaurieEmma SaylorJason MeyerEllen VenzKrista WetzigCraig FrenchForbes McgainJohn MulderGerard FennessySathyajith KoottayiSamantha BatesMiriam TownsRebecca MorganAnna TippettAndrew UdyChris MasonElisa LicariDashiell GantnerJason McclureAlistair NicholPhoebe MccrackenJasmin BoardEmma MartinShirley VallanceMeredith YoungChelsey VladicSteve McgloughlinDavid GattasHeidi BuhrJennifer ColesDebra HutchJames WunLouise ColeChristina WhiteheadJulie LowreyKristy MastersRebecca GreshamVictoria CampbellDavid GutierrezJane BrailsfordLoretta ForbesLauren MurrayTeena MaguireMartina NichonghaileNeil OrfordAllison BoneTania ElderkinTania SalernoTim ChimundaJason FletcherEmma BroadfieldSanjay PorwalCameron KnottCatherine BoschertJulie SmithAngus RichardsonDianne HillGraeme DukePeter OziemskiSantiago CegarraPeter ChanDeborah WelshStephanie HunterOwen RoodenburgJohn DyettNicos KokotsisMax MoserYang YangLaven PadayacheeJoseph VetroHimangsu GangopadhyayMelissa KaufmanAngaj GhoshSimone SaidAlpesh PatelShailesh BihariElisha MathesonXia JinTapaswi ShresthaKate SchwartzMartin GallagherRosalba CrossWinston CheungHelen WongMark KolAsim ShahAmanda WangZoltan EndreCelia BradfordPierre JaninSimon FinferNaomi DielJonathan GatwardNaomi HammondAnthony DelaneyFrances BassElizabeth YaradHergen BuscherClaire ReynoldsNerilee BakerMichael JoannidisRomuald BellmannAndreas PeerJulia HasslacherPaul KoglbergerSebastian KleinKlemens ZotterAnna BrandtnerArmin FinkenstedtAdelheid DitlbacherFrank HartigDietmar FriesMirjam BachlerBettina SchenkMartin WagnerPhilipp EllerThomas StaudingerEsther TillerPeter SchellongowskiAndja BojicEric HosteStephanie BrackeLuc De CropDaisy VermeirenFernando ThomeBianca ChiellaLucia FendtVeronica AntunesFrançois LamontagneFrédérick d'AragonCharles St-ArnaudMichael MayetteÉlaine CarbonnaeuJoannie MarchandMarie-Hélène MasseMarilène LadouceurAlexis TurgeonFrançois LauzierDavid BellemareCharles Langis FrancoeurGuillaume LeblancGabrielle GuilbaultStéphanie GrenierEve CloutierAnnick BoivinCharles Delisle-ThibaultPanagiota GiannakourosOlivier CosterousseJean-François CailhierFrançois-Martin CarrierAli GhamraouiMartine LebrasseurFatna BenettaibMaya SalaméDounia BoumahniYing Tung SiaJean-François NaudIsabelle RoyHenry StelfoxStacey RuddellBraden MannsShelley DugganDominic CarneyJennifer BarchardRichard WhitlockEmilie Belley-CoteNevena SavijaAlexandra SabevTroy CampbellThais CrearyKelson DevereauxShira BrodutchClaudio RigattoBojan PaunovicOwen MooneyAnna GlybinaOksana HarasemiwMichelle Di NellaJohn HarmonNavdeep MehtaLouis LakatosNicole HaslamFrancois LelloucheMathieu SimonYing TungPatricia LizottePierre-Alexandre BourchardBram RochwergTim KarachiTina MillenJohn MuscedereDavid MasloveJ. Gordon BoydStephanie SibleyJohn DroverMiranda HuntIlinca GeorgescuRandy WaxIlan LengaKavita SridharAndrew SteeleKelly FuscoTaneera GhateMichael TolibasHolly RobinsonMatthew WeirRavi TanejaIan BallAmit GargEileen CampbellAthena OvsenekSean BagshawSean Van DiepenNadia BaigSheldon MagderHan YaoAhsan AlamJosie CampisiErika MacintyreElla RokoshKimberly ScherrStephen LapinskySangeeta MehtaSumesh ShahDaniel NivenHenry StelfoxStacey RuddellMichael RussellKym JimGillian BrownKerry OxtobyAdam HallLuc BenoitColleen SokolowskiBhanu PrasadJag RaoShelley GiebelDemetrios KutsogiannisPatricia ThompsonTayne ThompsonRobert CironeKanthi KavikondalaMark SothFrance ClarkeAlyson TakaokaRon WaldDavid MazerKaren BurnsJan FriedrichDavid KleinGyan SandhuMarlene SantosImrana KhalidJennifer HodderPeter DodekNajib AyasVictoria AlcuazGabriel SuenOleksa RewaGurmeet SinghSean NorrisNeil GibsonCastro AriasAysha ShamiCeline PelletierNeill K.J. AdhikariAlireza ZahiriehAndre AmaralNicole MarinoffNavjot KaurAdic PerezJane WangGregory HaljanChristopher CondinLauralyn McintyreBrigette GomesRebecca PorteousIrene WatpoolSwapnil HiremathEdward ClarkMargaret HerridgeFelicity BackhouseM. Elizabeth WilcoxKarolina WalczakVincent KiAsheer SharmanMartin RomanoSean BagshawR.T. Noel GibneyAdam RomanovskyOleksa RewaLorena MccoshenNadia BaigGordon WoodDaniel OvakimFiona AuldGayle CarneyMeili DuanXiaojun JiDongchen GuoZhili QiJin LinMeng ZhangLei DongJingfeng LiuPei LiuDeyuan ZhiGuoqiang BaiYu QiuZiqi YangJing BaiZhuang LiuHaizhou ZhuangHaiman WangJian LiMengya ZhaoXiao ZhouXianqing ShiBaning YeManli LiuJing WuYongjian FuDali LongYu PanJinlong WangHuaxian MeiSongsong ZhangMingxiang WenEnyu YangSijie MuJianquan LiTingting HuBingyu QinMin LiCunzhen WangXin DongKaiwu WangHaibo WangJianxu YangBin DuChuanyao WangDongxin WangNan LiZhui YuSong XuLan YaoGuo HouZhou LiuLiping LuYingtao LianChunting WangJichen ZhangRuiqi DingGuoqing QiQizhi WangPeng WangZhaoli MengMan ChenXiaobo HuXiandi HeShibing ZhaoLele HangRui LiSuhui QinKun LuShijuan DunCheng LiuQi ZhouZhenzhen ChenJing MeiMinwei ZhangHao XuJincan LinQindong ShiLijuan FuQinjing ZengHongye MaJinqi YanLan GaoHongjuan LiuLei ZhangHao LiXiaona HeJingqun FanLitao GuoYu LiuXue WangJingjing SunZhongmin LiuJuan YangLili DingLulu ShengXingang LiuJie YanQuihui WangYifeng WangDan ZhaoShuangping ZhaoChenghuan HuJing LiFuxing DengHaibo QuiYi YangMin MoChun PanChangde WuYingzi HuangLili HuangAiran LiuVille PettiläSuvi VaaraAnna-Maija KorhonenSanna TörnblomSari SutinenLeena PettiläJonna HeinonenEliria LappiTaria SuhonenSari KarlssonSanna HoppuVille JalkanenAnne KuitunenMarkus LevorantaJaakko LångsjöSanna RistimäkiKaisa MalilaAnna WoottenSimo VarilaMikko JärvisaloOuti InkinenSatu KentalaKeijo LeivoPaivi HaltiaDidier DreyfussJean-Damien RicardJonathan MessikaAbirami TiagarajahMalo EmeryAline DechanetCoralie GernezDamien RouxLaurent Martin-LefevreMaud FiancetteIsabelle VinatierJean Claude LacheradeGwenhaël ColinChristine LebertMarie-Ange AzaisAihem YehiaCaroline PoupletMatthieu Henry- LagarrigueAmélie SeguinLaura CrosbyJulien MaizelDimitri Titeca-BeauportAlain CombesAnia NieszkowskaPaul MasiAlexandre DemouleJulien MayauxMartin DresElise MorawiecMaxens DecalveleSuela DemiriMorgane FaureClémence MariosMaxime MalletMarie Amélie OrdonLaura MorizotMarie CantienFrançois PoussetStéphane GaudryFlorent PoirsonYves CohenLaurent ArgaudMartin CourLaurent BitkerMarie SimonRomain HernuThomas BaudrySylvie de la SalleAdrien RobineNicholas SedillotXavier TchenioCamille BouisseSylvie RouchFabienne TamionSteven GrangéDorothée CarpentierGuillaume ChevrelLuis Ensenyat-MartinSophie MarqueJean-Pierre QuenotPascal AndreuAuguste DargentAudrey LargeNicolas ChudeauMickael LandaisBenoit DerrienJean Christophe CallahanChristophe GuittonCharlène Le MoalAlain RobertKarim AsehnouneRaphael CinottiNicolas GrillotDominique DemeureChristophe VinsonneauImen RahmaniMehdi MarzoukThibault DekeyserCaroline SejourneMélanie VerlayFabienne TheveninLucie DelecolleDidier TheveninBertrand SouweineElisabeth CoupezMireille AddaJean-Pierre EraldiAntoine MarchalotNicolas de ProstArmand Mekontso DessapKeyvan RazaziFerhat MezianiJulie Boisrame-HelmsRaphaël Clere-JehlXavier DelabrancheChristine KummerlenHamid MerdjiAlexandra MonnierYannick RabouelHassene RahmaniHayat AllamSamir ChenafVincenta FranjaBertrand PonsMichel CarlesFrédéric MartinoRégine RichardBenjamin ZuberGuillaume LacaveKarim LakhalBertrand RozecHoa Dang VanÉric BouletFouad FadelCedric CleophaxNicolas DufourCaroline GrantMarie ThuongJean ReignierEmmanuel CanetLaurent NicoletThierry BoulainMai-Anh NayDalila BenzekriFrançois BarbierAnne BretagnolToufik KamelArmelle MathonnetGrégoire MullerMarie SkarzynskiJulie RossiAmandine PradetSandra Dos SantosAurore GueryLucie MullerLuis FelixJulien BohéGuillaume ThiéryNadia AissaouiDamien VimpereMorgane CommeureucJean-Luc DiehlEmmanuel GuerotOrfeas LiangosMonika WittigAlexander ZarbockMira KüllmarThomas van WaegeninghNadine RosenowAlistair NicholKathy BrickellPeter DoranPatrick MurrayGiovanni LandoniRosalba LemboAlberto ZangrilloGiacomo MontiMargherita TozziMatteo MarzaroliGaetano LombardiGianluca PaternosterMichelangelo VitielloShay McguinnessRachael ParkeMagdalena ButlerEileen GilderKeri-Anne CowdreySamantha WallaceJane HallionMelissa WoolettPhilippa NealKarina DuffyStephanie LongColin McarthurCatherine SimmondsYan ChenRachael McconnochieLynette NewbyDavid KnightSeton HendersonJan MehrtensStacey MorganAnna MorrisKymbalee Vander HaydenTara BurkeMatthew BaileyRoss FreebairnLesley ChadwickPenelope ParkChristine RollsLiz ThomasUlrike BuehnerErin WilliamsJonathan AlbrettSimon KirkhamCarolyn JacksonTroy BrowneJennifer GoodsonDavid JacksonJames HoughtonOwen CallenderVicki HigsonOwen KeetClive DominyPaul YoungAnna HuntHarriet JuddCassie LawrenceShaanti OlatunjiYvonne RobertsonCharlotte Latimer-BellDeborah HendryAgnes Mckay-VucagoNina BeehreEden LesonaLeanlove NavarraChelsea RobinsonRyan JangAndrea JungeBridget LambertAntoine SchneiderMichel ThibaultPhilippe EckertSébastien KisslingErietta PolychronopoulosElettra PoliMarco AltarelliMadeleine SchnorfSamia Abed MallairdClaudia HeideggerAurelie PerretPhilippe MontillierFrederic SanglaSeigenthaller NeilsAude De WattevilleMandeep-Kaur PhullAparna GeorgeNauman HussainTatiana PogrebanSteve LobazAlison DanielsMishell CunninghamDeborah KerrAlice NicholsonPradeep ShanmugasundaramJudith AbramsKatarina MansoGeraldine HambrookElizabeth MckerrowJuvy SalvaStephen FoulkesMatthew WiseMatt MorganJenny BrooksJade ColeTracy Michelle DaviesHelen HillEmma ThomasMarcela VizcaychipiBehrad BaharloJaime CarungcongPatricia CostaLaura MartinsRitoo KapoorTracy HazeltonAngela MoonJanine MusselwhiteBen ShelleyPhilip MccallMarlies OstermannGill ArbaneAneta BociekMartina MarottiRosario LimSara CamposNeus Grau NovellasArmando CennamoAndrew SlackDuncan WyncollLuigi CamporotaSimon SparkesRosalinde TilleyAustin RattrayGayle MorelandJane DuffyElizabeth McgonigalPhilip HopkinsClare FinneyJohn SmithHarriet NobleHayley WatsonClaire-Louise HarrisEmma ClareyEleanor CorcoranJames BeckClare HowcroftNora YoungsElizabeth WilbyBethan OggAdam WolversonSandra LeeSusie ButlerMaryanne OkubanjoJulia HindleIngeborg WeltersKaren WilliamsEmily JohnsonJulie Patrick-HeseltonDavid ShawVictoria WaughRichard StewartEsther MwauraLynn WrenLouise MewSara-Beth SutherlandJane AdderleyJim RuddyMargaret HarkinsCallum KayeTeresa ScottWendy MitchellFelicity AndersonFiona WilloxVijay JagannathanMichele ClarkSarah PurvAndrew SharmanMegan MeredithLucy RyanLouise ConnerCecilia PetersDan HarveyAshraf RoshdyAmy CollinsMalcolm SimSteven HendersonNigel CheeSally PittsKatie BowmanMaria DilawershahLuke VamplewElizabeth HowePaula RogersClara HernandezClara PrendergastJane BentonAlex RosenbergLui ForniAlice GrantPaula CarvelliAjay RaithathaSarah BirdMax RichardsonMatthew NeedhamClaire HirstJonathan BallSusannah LeaverLuisa HowlettCarlos Castro DelgadoSarah Farnell-WardHelen FarrahGeraldine GrayGipsy JosephFrancesca RobinsonAscanio TridenteClare HarropKaren ShukerDerek MclaughlanJudith RamseySharon MeehanBernd Oliver RoseRosie Reece-AnthonyBabita GurungTony WhitehouseCatherine SnelsonTonny VeenithAndy JohnstonLauren CooperRon CarreraKaren EllisEmma FellowsSamanth HarkettColin BerginElaine SpruceLiesl DespyStephanie GoundryNatalie DooleyTracy MasonAmy ClarkGemma DignamGeraldine WardBen AttwoodPenny ParsonsSophie MasonMichael MargarsonJenny LordPhilip McgloneLuke HodgsonIndra ChadbournRaquel GomezJordi MargalefRinus PretoriusAlexandra HamshereJoseph CarterHazel CahillLia GraingerKate HowardGreg ForshawZoe GuyKianoush KashaniRobert AlbrightAmy AmsbaughAnita StoltenbergAlexander NivenMatthew LynchAnnmarie O'MaraSyed NaeemSairah SharifJoyce Mckenney GoulartMatthew LynchAnnmarie O'MaraSyed NaeemSairah SharifJoyce Mckenney GoulartAshita TolwaniClaretha LyasLaura LattaAzra BihoracHaleh HashemighouchaniPhilip EfronMatthew RuppertJulie CupkaSean KileyJoshua CarsonPeggy WhiteGeorge OmalaySherry BrownLaura VelezAlina MarceronJavier NeyraJuan Carlos AycinenaMadona EliasVictor Ortiz-SorianoCaroline HauschildRobert Dorfman
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Annals of the American Thoracic Society le 26/10/2020

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Lucia GrengaOlivier PibleGuylaine MiotelloKaren CulottaSylvie RuatMarie‐anne RoncatoFabienne GasLaurent BellangerPierre-Géraud ClaretCatherine Dunyach-RémyDidier LaureillardAlbert SottoJean-Philippe LavigneJean Armengaud
• Organismes : Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nîmes Pathogenesis and Control of Chronic and Emerging Infections Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques Hôpital Universitaire Carémeau [Nîmes] Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Laboratoire Innovations technologiques pour la Détection et le Diagnostic
• Publié dans Environmental Microbiology le 30/10/2020

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Résumé : Since the beginning of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the gastrointestinal (GI) tract has emerged as an important organ influencing the propensity to and potentially the severity of the related COVID-19 disease. However, the contribution of the SARS-CoV-2 intestinal infection on COVID-19 pathogenesis remains to be clarified. In this exploratory study, we highlighted a possible link between alterations in the composition of the gut microbiota and the levels of SARS-CoV-2 RNA in the gastrointestinal tract, which could be more important than the presence of SARS-CoV-2 in the respiratory tract, COVID-19 severity and GI symptoms. As established by metaproteomics, altered molecular functions in the microbiota profiles of high SARS-CoV-2 RNA level faeces highlight mechanisms such as inflammation-induced enterocyte damage, increased intestinal permeability and activation of immune response that may contribute to vicious cycles. Uncovering the role of this gut microbiota dysbiosis could drive the investigation of alternative therapeutic strategies to favour the clearance of the virus and potentially mitigate the effect of the SARS-CoV-2 infection.

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Fichiers liés : EMI-24-4299.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Vincent CottinPhilippe BonniaudJacques CadranelBruno CrestaniStéphane JouneauSylvain Marchand-AdamHilario NunesLidwine Wémeau-StervinouEmmanuel BergotElodie BlanchardRaphaël BorieArnaud BourdinCécile ChenivesseAnnick ClémentEmmanuel GomezAnne GondouinSandrine HirschiFrançois LebargyCharles-Hugo MarquetteDavid MontaniGrégoire PrévotSébastien QuetantMartine Reynaud-GaubertMathieu SalaunOlivier SanchezBruno TrumbicKarim BerkaniPierre Yves BrilletMarion CampanaLara ChalabreysseGérard ChattéDidier DebieuvreGilbert FerrettiJean-Michel FourrierNicolas JustMarianne KambouchnerBertrand LegrandFrédéric Le GuillouJean-Pierre LhuillierAnas MehdaouiJean-Marc NaccacheCatherine PaganonMartine Rémy-JardinSalim Si-MohamedPhilippe Terrioux
• Organismes : Infections Virales et Pathologie Comparée - UMR 754 Centre national de référence des maladies pulmonaires rares [Lyon] Lipides - Nutrition - Cancer [Dijon - U1231] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Service de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon] CHU Tenon [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Hôpital Bretonneau Hôpital Avicenne [AP-HP] Institut Coeur Poumon [CHU Lille] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Pessac AP-HP - Hôpital Bichat - Claude Bernard [Paris] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 Maladies génétiques d'expression pédiatrique Centre Hospitalier Régional Universitaire de Besançon Nouvel Hôpital Civil de Strasbourg Hôpital universitaire Robert Debré [Reims] Hôpital Pasteur [Nice] Institut de Recherche sur le Cancer et le Vieillissement Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire [CHU Grenoble] CHU Marseille Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Centre d'Investigation Clinique [CHU Rouen] Hôpital Européen Georges Pompidou [APHP] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Centre Hospitalier Regional d'Orléans Hospices Civils de Lyon Centre Hospitalier Emile Muller [Mulhouse] Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Avicenne [AP-HP] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Centre Hospitalier Eure-Seine - Hôpital d'Evreux - Vernon (Evreux) Groupe Hospitalier Paris Saint-Joseph Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie Institut Coeur Poumon [CHU Lille] Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
• Publié dans Revue des Maladies Respiratoires le 31/10/2020

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Résumé : Contexte :Depuis les précédentes recommandations françaises publiées en 2017, les connaissances concernant la fibrose pulmonaire idiopathique ont évolué sur de nombreux aspects.Méthodes :Des recommandations pratiques ont été établies à l’initiative du Centre coordonnateur de référence des maladies pulmonaires rares, sous l’égide de la Société de Pneumologie de Langue Française, par un groupe de coordination, un groupe de rédaction, et un groupe de lecture, impliquant l’ensemble du réseau OrphaLung, des pneumologues de divers modes d’exercice, des radiologues, des pathologistes, un médecin généraliste, un cadre de santé, et une association de patients. La méthode a respecté les règles d’élaboration des « Bonnes pratiques cliniques » selon la méthode des « Recommandations pour la pratique clinique » de la Haute Autorité de Santé, incluant un vote en ligne selon une échelle Likert.Résultats :Après une analyse bibliographique, 54 recommandations ont été formulées, améliorées, puis validées par les groupes de travail, portant sur des aspects multiples de la maladie : épidémiologie, modalités diagnostiques, critères de qualité et interprétation du scanner thoracique, indication et réalisation de la biopsie pulmonaire, bilan étiologique, modalités et indications de l’enquête familiale et de l’analyse génétique, évaluation du retentissement fonctionnel et du pronostic, indication et emploi des médicaments antifibrosants, transplantation pulmonaire, prise en charge des symptômes, comorbidités et complications, traitement de l’insuffisance respiratoire chronique, diagnostic et prise en charge des exacerbations aiguës de fibrose.Conclusion :Ces recommandations fondées sur les preuves sont destinées à guider le diagnostic et la prise en charge pratique de la fibrose pulmonaire idiopathique.

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Fichiers liés : Cottin et al - 2022 - Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire _2021_09_12_RecoFPI_R1_Clean_c.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2022
• Auteurs : Emil HagströmPhilippe Gabriel StegMichael SzarekDeepak BhattVera BittnerNicolas DanchinRafael DiazShaun GoodmanRobert HarringtonJ. Wouter JukemaEvangelos LiberopoulosNikolaus MarxJennifer McginnissGaren ManvelianRobert PordyMichel ScemamaHarvey WhiteAndreas ZeiherGregory SchwartzGregory SchwartzDeepak BhattVera BittnerRafael DiazShaun GoodmanRobert HarringtonJ. Wouter JukemaMichael SzarekHarvey WhiteAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefRobert PordyWilliam SasielaJean-François TambyRafael DiazPhilip AylwardHeinz DrexelPeter SinnaeveMirza DilicRenato LopesNina GotchevaShaun GoodmanJuan-Carlos PrietoHuo YongPatricio López-JaramilloIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo CarlosMontenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsHarvey WhiteSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmUlf LandmesserChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyMatthew RoeRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsPierluigi TricociJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisRenato LopesDavid MaronKenneth MahaffeyJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicÉtienne PuymiratMatthew RoeWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio JureJulio Oe BonoAdrian HrabarJulio VallejosRodolfo Ahuad GuerreroFederico NovoaCristian PatocchiCesar ZaidmanMaria GiulianoRicardo DranMarisa VicoGabriela CarneroPablo GuzmanJuan Medrano AllendeDaniela Garcia BrascaMiguel Bustamante LabartaSebastian NaniEduardo Ds BlumbergHugo ColomboAlberto LibermanVictorino FuentealbaHector LuciardiGabriel WaismanMario BerliRuben Garcia DuranHoracio CestariHugo LuquezJorge GiordanoSilvia SaavedraGerardo ZapataOsvaldo CostamagnaSusana LloisJonathon WaitesNicholas CollinsAllan SowardPhilip AylwardChris Ls HiiPhilip AylwardJames ShawMargaret ArstallJohn HorowitzDaniel NinioJames RogersDavid ColquhounRomulo Oqueli FloresPhilip Roberts-ThomsonOwen RaffelSam LehmanConstantine AroneySteven Gm CoverdalePaul GarrahyGregory StarmerMark SaderPatrick CarrollRonald DickRobert ZweikerUta HoppeHeinz DrexelKurt HuberRudolf BergerGeorg Delle-KarthBernhard FreyFranz WeidingerDirk FaesKurt HermansBruno PirenneAttilio LeoneEtienne HofferPeter SinnaeveMathias Cm VrolixLuc De WolfBart WollaertMarc CastadotKarl DujardinChristophe BeauloyeGeert VervoortHarry StriekwoldCarl ConvensJohn RoosenEmanuele BarbatoMarc ClaeysFrank CoolsIbrahim TerzicFahir BarakovicZlatko MidzicBelma PojskicEmir FazlibegovicMirza DilicAzra Durak-NalbanticMehmed KulićDusko VulicAdis MuslibegovicBoris GoronjaGilmar ReisLuciano SousaJose NicolauFlavio GiorgetoRicardo SilvaLilia Nigro MaiaRafael RechPaulo Rf RossiMaria José Ag CerqueiraNorberto DudaRenato KalilAdrian KormannJosé Antonio M AbrantesPedro Pimentel FilhoAna Priscila SoggiaMayler On de SantosFernando NeuenschwanderLuiz BodaneseYorghos MichalarosFreddy EliaschewitzMaria VidottiPaulo LeaesRoberto BotelhoSergio KaiserEuler Roberto F Fernandes ManentiDalton PrecomaJose Moura JorgePedro SilvaJose SilveiraWladmir SaporitoJose NetoGilson FeitosaLuiz Eduardo F RittJuliana de SouzaFernando CostaWeimar Ksb SouzaHelder Jl ReisRenato LopesLeandro MachadoJosé Carlos Aidar AyoubGeorgi TodorovFedya NikolovElena VelchevaMaria TzekovaHaralambi BenovStanislav PetranovHaralin TumbevNina Shehova-YankovaDimitar MarkovDimitar RaevMihail MollovKostadin KichukovKatya Ilieva- PandevaNina GotchevaRaya IvanovaMaryana GospodinovValentina MinchevaPetar LazovBojidar DimovManohara SenaratneJames StoneJan KornderStephen PearceDanielle DionDaniel SavardYves PesantAmritanshu PandeySimon RobinsonGilbert GosselinSaul VizelGordon HoagRonald BourgeoisAnne MorissetEric SabbahBruce SussexSimon KouzPaul MacdonaldAriel DiazNicolas MichaudDavid FellRaymond LeungTycho VuurmansChristopher LaiFrank NigroRichard DaviesGustavo NogaredaRam VijayaraghavanJohn DucasSerge LepageShamir MehtaJames ChaRobert DupuisPeter FongSohrab LutchmedialJosep Rodes-CabauHussein FadlallahDavid ClevelandThao HuynhIqbal BataAdnan HameedCristian PincettiSergio PotthoffJuan PrietoMonica AcevedoArnoldo AguirreMargarita VejarMario YañezGuillermo AranedaMauricio FernandezLuis PerezPaola VarletaFernando FlorenzanoLaura HuidobroCarlos RaffoClaudia OlivaresLeonardo NahuelpanHumberto MontecinosJiyan ChenYugang DongWeijian HuangJianzhong WangShi’an HuangZhuhua YaoXiang LiLan CuiWenhua LinYuemin SunJingfeng WangJianping LiXuelian ZhangHong ZhuDandan ChenLan HuangShaohong DongGuohai SuBiao XuXi SuXiaoshu ChengJinxiu LinWenxia ZongHuanming LiYi FengDingli XuXinchun YangYuannan KeXuefeng LinZheng ZhangZeqi ZhengZhurong LuoYundai ChenChunhua DingYi ZhongYang ZhengXiaodong LiDaoquan PengShuiping ZhaoYing LiXuebo LiuMeng WeiShaowen LiuYihua YuBaiming QuWeihong JiangYujie ZhouXingsheng ZhaoZuyi YuanYing GuoXiping XuXubo ShiJunbo GeGuosheng FuFeng BaiWeiyi FangXiling ShouXiangjun YangJian’an WangMeixiang XiangYingxian SunQinghua LuRuiyan ZhangJianhua ZhuYizhou XuZhongcai FanTianchang LiChun WuNicolas JaramilloGregorio Sanchez VallejoDiana Luna BotiaRodrigo Botero LopezDora de SalazarAlberto BonfantiCarlos Cotes ArocaJuan Diego HigueraMarco BlanquicettSandra Barrera SilvaHenry Garcia LozadaJulian Coronel ArroyoJose Accini MendozaRicardo Fernandez RuizAlvaro Quintero OssaFernando Manzur JatinAristides Sotomayor HerazoJeffrey Castellanos ParadaRafael Suarez ArambulaMiguel Urina TrianaAngela TrujilloMaja StrozziSiniša CarDavor MiličićMartina Lovrić BenčićHrvoje PintarićĐeiti PrvulovićJozica ŠikićViktor PeršićDean MiletaKresimir ŠtambukZdravko BabićVjekoslav TomulicJosip LukendaStanka Mejic-KrstulovicBoris StarcevicJindrich SpinarDavid HorakZdenek VelickaDavid AlanVilma MachovaAles LinhartVojtech NovotnyVladimir KaucakRichard RokytaRobert NaplavaZdenek CoufalVera AdamkovaIvo PodperaJiri ZizkaZuzana MotovskaIvana MarusincovaPetr OstadalPetr HeincJiri KucharPetr PovolnyJiri MatuskaSteen PoulsenBent RaungaardPeter ClemmensenLia BangOle MayMorten BøttcherJens HoveLars FrostGunnar GislasonJohn LarsenPeter Betton JohansenFlemming HaldPeter JohansenJørgen JeppesenTonny NielsenKjeld KristensenPiotr Maria WalichiewiczJens LomholdtIb KlausenPeter Kaiser NielsenFlemming DavidsenLars VidebaekMargus ViigimaaMai SootsVeiko VahulaAnu HedmanÜllar SoopõldKaja MärtsinTiina JurgensonArved KristjanMarkku NieminenSaila VikmanHeikki HuikuriJuhani AiraksinenPierre CosteEmile FerrariNicolas DanchinOlivier MorelGilles MontalescotJacques MachecourtGilles Barone-RochetteJacques MansouratiYves CottinFlorence LeclercqAbdelkader BelhassaneNicolas DelarcheFranck BoccaraFranck PaganelliJérôme ClercFrançois SchieleVictor AboyansVincent ProbstJacques BerlandThierry LefèvreVakhtang ChumburidzeIrakli KhintibidzeTamaz ShaburishviliZurab PagavaRamaz GhlontiZaza LominadzeGeorge KhabeishviliRayyan HemetsbergerKemala EdwardUrsula Rauch-KröhnertMatthias StratmannKarl-Friedrich AppelEkkehard SchmidtHeyder OmranChristoph StellbrinkThomas DorselEmmanouil LianopoulosHans Friedrich VöhringerRoger MarxAndreas ZirlikDetlev SchellenbergThomas HeitzerUlrich LaufsChristian WernerNikolaus MarxStephan GielenSebastian NudingBernhard WinkelmannSteffen BehrensKarsten SydowMahir KarakasGregor SimonisThomas MuenzelNikos WernerStefan LeggewieDirk BöckerRüdiger Braun- DullaeusNicole ToursarkissianMichael JeserichMatthias WeißbrodtTim SchaeufeleJoachim WeilHeinz VöllerJohannes WaltenbergerMohammed NatourSusanne SchmittDirk Müller-WielandStephan SteinerLothar HeidenreichElmar OffersUwe GremmlerHolger KillatWerner RiekerSotiris PatsilinakosAthanasios KartalisAthanassios ManolisDimitrios SionisGeargios ChachalisEvangelos LiberopoulosIoannis SkoumasVasilios AthyrosPanagiotis VardasFrangkiskos ParthenakisGeorgios HahalisJohn LekakisApostolos HatzitoliosSergio Fausto OvandoPablo Carlos Montenegro ValdovinosJuan Arango BeneckeEdgar Rodriguez de LeonBryan Py YanDavid Cw SiuTibor TuriBela MerkelyRobert Gabor KissImre UngiGeza LupkovicsLajos NagyAndrás KatonaIstván ÉdesGábor MüllerIván HorvathTibor KapinZsolt SzigetiJózsef FaluközyMukund KumblaManjinder SandhuSharath AnnamNaveen Reddy ProdduturReddy RegellaRajendra PremchandAjaykumar MahajanSudhir PawarAtul AbhyanakarPrafulla KerkarRavishankar GovindaAbraham OommanDhurjati SinhaSachin PatilDhiman KahaliJitendra 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• Organismes : Laboratoire de Recherche Vasculaire Translationnelle
• Publié dans Circulation le 29/10/2020

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Résumé : Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score–matched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9–3.6], 4.0 [95% CI, 3.6–4.5], and 5.5 [95% CI, 5.0–6.1] events per 100 patient-years in strata <75, 75–<90, ≥90 mg/dL, respectively; P trend <0.0001) and after adjustment for low-density lipoprotein cholesterol ( P trend =0.035). Higher baseline apoB stratum was associated with greater relative ( P trend <0.0001) and absolute reduction in MACE with alirocumab versus placebo. In the alirocumab group, the incidence of MACE after month 4 decreased monotonically across decreasing achieved apoB strata (4.26 [95% CI, 3.78–4.79], 3.09 [95% CI, 2.69–3.54], and 2.41 [95% CI, 2.11–2.76] events per 100 patient-years in strata ≥50, >35–<50, and ≤35 mg/dL, respectively). Compared with propensity score–matched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as ≤35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.

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