Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2022
• Auteurs : Emil HagströmPhilippe Gabriel StegMichael SzarekDeepak BhattVera BittnerNicolas DanchinRafael DiazShaun GoodmanRobert HarringtonJ. Wouter JukemaEvangelos LiberopoulosNikolaus MarxJennifer McginnissGaren ManvelianRobert PordyMichel ScemamaHarvey WhiteAndreas ZeiherGregory SchwartzGregory SchwartzDeepak BhattVera BittnerRafael DiazShaun GoodmanRobert HarringtonJ. Wouter JukemaMichael SzarekHarvey WhiteAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefRobert PordyWilliam SasielaJean-François TambyRafael DiazPhilip AylwardHeinz DrexelPeter SinnaeveMirza DilicRenato LopesNina GotchevaShaun GoodmanJuan-Carlos PrietoHuo YongPatricio López-JaramilloIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo CarlosMontenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsHarvey WhiteSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmUlf LandmesserChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyMatthew RoeRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsPierluigi TricociJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisRenato LopesDavid MaronKenneth MahaffeyJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicÉtienne PuymiratMatthew RoeWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio JureJulio Oe BonoAdrian HrabarJulio VallejosRodolfo Ahuad GuerreroFederico NovoaCristian PatocchiCesar ZaidmanMaria GiulianoRicardo DranMarisa VicoGabriela CarneroPablo GuzmanJuan Medrano AllendeDaniela Garcia BrascaMiguel Bustamante LabartaSebastian NaniEduardo Ds BlumbergHugo ColomboAlberto LibermanVictorino FuentealbaHector LuciardiGabriel WaismanMario BerliRuben Garcia DuranHoracio CestariHugo LuquezJorge GiordanoSilvia SaavedraGerardo ZapataOsvaldo CostamagnaSusana LloisJonathon WaitesNicholas CollinsAllan SowardPhilip AylwardChris Ls HiiPhilip AylwardJames ShawMargaret ArstallJohn HorowitzDaniel NinioJames RogersDavid ColquhounRomulo Oqueli FloresPhilip Roberts-ThomsonOwen RaffelSam LehmanConstantine AroneySteven Gm CoverdalePaul GarrahyGregory StarmerMark SaderPatrick CarrollRonald DickRobert ZweikerUta HoppeHeinz DrexelKurt HuberRudolf BergerGeorg Delle-KarthBernhard FreyFranz WeidingerDirk FaesKurt HermansBruno PirenneAttilio LeoneEtienne HofferPeter SinnaeveMathias Cm VrolixLuc De WolfBart WollaertMarc CastadotKarl DujardinChristophe BeauloyeGeert VervoortHarry StriekwoldCarl ConvensJohn RoosenEmanuele BarbatoMarc ClaeysFrank CoolsIbrahim TerzicFahir BarakovicZlatko MidzicBelma PojskicEmir FazlibegovicMirza DilicAzra Durak-NalbanticMehmed KulićDusko VulicAdis MuslibegovicBoris GoronjaGilmar ReisLuciano SousaJose NicolauFlavio GiorgetoRicardo SilvaLilia Nigro MaiaRafael RechPaulo Rf RossiMaria José Ag CerqueiraNorberto DudaRenato KalilAdrian KormannJosé Antonio M AbrantesPedro Pimentel FilhoAna Priscila SoggiaMayler On de SantosFernando NeuenschwanderLuiz BodaneseYorghos MichalarosFreddy EliaschewitzMaria VidottiPaulo LeaesRoberto BotelhoSergio KaiserEuler Roberto F Fernandes ManentiDalton PrecomaJose Moura JorgePedro SilvaJose SilveiraWladmir SaporitoJose NetoGilson FeitosaLuiz Eduardo F RittJuliana de SouzaFernando CostaWeimar Ksb SouzaHelder Jl ReisRenato LopesLeandro MachadoJosé Carlos Aidar AyoubGeorgi TodorovFedya NikolovElena VelchevaMaria TzekovaHaralambi BenovStanislav PetranovHaralin TumbevNina Shehova-YankovaDimitar MarkovDimitar RaevMihail MollovKostadin KichukovKatya Ilieva- PandevaNina GotchevaRaya IvanovaMaryana GospodinovValentina MinchevaPetar LazovBojidar DimovManohara SenaratneJames StoneJan KornderStephen PearceDanielle DionDaniel SavardYves PesantAmritanshu PandeySimon RobinsonGilbert GosselinSaul VizelGordon HoagRonald BourgeoisAnne MorissetEric SabbahBruce SussexSimon KouzPaul MacdonaldAriel DiazNicolas MichaudDavid FellRaymond LeungTycho VuurmansChristopher LaiFrank NigroRichard DaviesGustavo NogaredaRam VijayaraghavanJohn DucasSerge LepageShamir MehtaJames ChaRobert DupuisPeter FongSohrab LutchmedialJosep Rodes-CabauHussein FadlallahDavid ClevelandThao HuynhIqbal BataAdnan HameedCristian PincettiSergio PotthoffJuan PrietoMonica AcevedoArnoldo AguirreMargarita VejarMario YañezGuillermo AranedaMauricio FernandezLuis PerezPaola VarletaFernando FlorenzanoLaura HuidobroCarlos RaffoClaudia OlivaresLeonardo NahuelpanHumberto MontecinosJiyan ChenYugang DongWeijian HuangJianzhong WangShi’an HuangZhuhua YaoXiang LiLan CuiWenhua LinYuemin SunJingfeng WangJianping LiXuelian ZhangHong ZhuDandan ChenLan HuangShaohong DongGuohai SuBiao XuXi SuXiaoshu ChengJinxiu LinWenxia ZongHuanming LiYi FengDingli XuXinchun YangYuannan KeXuefeng LinZheng ZhangZeqi ZhengZhurong LuoYundai ChenChunhua DingYi ZhongYang ZhengXiaodong LiDaoquan PengShuiping ZhaoYing LiXuebo LiuMeng WeiShaowen LiuYihua YuBaiming QuWeihong JiangYujie ZhouXingsheng ZhaoZuyi YuanYing GuoXiping XuXubo ShiJunbo GeGuosheng FuFeng BaiWeiyi FangXiling ShouXiangjun YangJian’an WangMeixiang XiangYingxian SunQinghua LuRuiyan ZhangJianhua ZhuYizhou XuZhongcai FanTianchang LiChun WuNicolas JaramilloGregorio Sanchez VallejoDiana Luna BotiaRodrigo Botero LopezDora de SalazarAlberto BonfantiCarlos Cotes ArocaJuan Diego HigueraMarco BlanquicettSandra Barrera SilvaHenry Garcia LozadaJulian Coronel ArroyoJose Accini MendozaRicardo Fernandez RuizAlvaro Quintero OssaFernando Manzur JatinAristides Sotomayor HerazoJeffrey Castellanos ParadaRafael Suarez ArambulaMiguel Urina TrianaAngela TrujilloMaja StrozziSiniša CarDavor MiličićMartina Lovrić BenčićHrvoje PintarićĐeiti PrvulovićJozica ŠikićViktor PeršićDean MiletaKresimir ŠtambukZdravko BabićVjekoslav TomulicJosip LukendaStanka Mejic-KrstulovicBoris StarcevicJindrich SpinarDavid HorakZdenek VelickaDavid AlanVilma MachovaAles LinhartVojtech NovotnyVladimir KaucakRichard RokytaRobert NaplavaZdenek CoufalVera AdamkovaIvo PodperaJiri ZizkaZuzana MotovskaIvana MarusincovaPetr OstadalPetr HeincJiri KucharPetr PovolnyJiri MatuskaSteen PoulsenBent RaungaardPeter ClemmensenLia BangOle MayMorten BøttcherJens HoveLars FrostGunnar GislasonJohn LarsenPeter Betton JohansenFlemming HaldPeter JohansenJørgen JeppesenTonny NielsenKjeld KristensenPiotr Maria WalichiewiczJens LomholdtIb KlausenPeter Kaiser NielsenFlemming DavidsenLars VidebaekMargus ViigimaaMai SootsVeiko VahulaAnu HedmanÜllar SoopõldKaja MärtsinTiina JurgensonArved KristjanMarkku NieminenSaila VikmanHeikki HuikuriJuhani AiraksinenPierre CosteEmile FerrariNicolas DanchinOlivier MorelGilles MontalescotJacques MachecourtGilles Barone-RochetteJacques MansouratiYves CottinFlorence LeclercqAbdelkader BelhassaneNicolas DelarcheFranck BoccaraFranck PaganelliJérôme ClercFrançois SchieleVictor AboyansVincent ProbstJacques BerlandThierry LefèvreVakhtang ChumburidzeIrakli KhintibidzeTamaz ShaburishviliZurab PagavaRamaz GhlontiZaza LominadzeGeorge KhabeishviliRayyan HemetsbergerKemala EdwardUrsula Rauch-KröhnertMatthias StratmannKarl-Friedrich AppelEkkehard SchmidtHeyder OmranChristoph StellbrinkThomas DorselEmmanouil LianopoulosHans Friedrich VöhringerRoger MarxAndreas ZirlikDetlev SchellenbergThomas HeitzerUlrich LaufsChristian WernerNikolaus MarxStephan GielenSebastian NudingBernhard WinkelmannSteffen BehrensKarsten SydowMahir KarakasGregor SimonisThomas MuenzelNikos WernerStefan LeggewieDirk BöckerRüdiger Braun- DullaeusNicole ToursarkissianMichael JeserichMatthias WeißbrodtTim SchaeufeleJoachim WeilHeinz VöllerJohannes WaltenbergerMohammed NatourSusanne SchmittDirk Müller-WielandStephan SteinerLothar HeidenreichElmar OffersUwe GremmlerHolger KillatWerner RiekerSotiris PatsilinakosAthanasios KartalisAthanassios ManolisDimitrios SionisGeargios ChachalisEvangelos LiberopoulosIoannis SkoumasVasilios AthyrosPanagiotis VardasFrangkiskos ParthenakisGeorgios HahalisJohn LekakisApostolos HatzitoliosSergio Fausto OvandoPablo Carlos Montenegro ValdovinosJuan Arango BeneckeEdgar Rodriguez de LeonBryan Py YanDavid Cw SiuTibor TuriBela MerkelyRobert Gabor KissImre UngiGeza LupkovicsLajos NagyAndrás KatonaIstván ÉdesGábor MüllerIván HorvathTibor KapinZsolt SzigetiJózsef FaluközyMukund KumblaManjinder SandhuSharath AnnamNaveen Reddy ProdduturReddy RegellaRajendra PremchandAjaykumar MahajanSudhir PawarAtul AbhyanakarPrafulla KerkarRavishankar GovindaAbraham OommanDhurjati SinhaSachin PatilDhiman KahaliJitendra SawhneyAbhijeet JoshiSanjeev ChaudharyPankaj HarkutSantanu GuhaSanjay PorwalSrimannarayana JujjuruRamesh PothineniMinguel MonteiroAziz KhanShamanna IyengarJasprakash Singh GrewalManoj ChopdaMahesh FulwaniDr. Aparna PatangePatil SachinVijay ChopraNaresh GoyalRituparna ShindeGajendra ManaksheNitin PatkiSumeet SethiVengatesh MunusamySunil Karnaand Sunil ThanviSrilakshmi AdhyapakChandrakant PatilUlhas PandurangiRishabh MathurJugal GuptaSuhas KalashettiAjit BhagwatBagirath RaghuramanShiv Kumar YerraPrasant BhansaliRohidas BorsePatil RahulSrihari DasVinay KumarJabir AbdullakuttyShireesh SaathePriya PalimkarJabir AbdullkuttyShireesh SatheShaul AtarMichael ShechterMorris MosseriYaron ArbelChorin EhudHavakuk OferChaim LotanUri RosenscheinAmos KatzYaakov HenkinAdi FrancisMarc KlutsteinEugenia NikolskyRobert ZukermannYoav TurgemanMajdi HalabiAlon MarmorRan KornowskiMichael JonasOffer AmirYonathan HasinYoseph RozenmanShmuel FuchsVered ZviOsamah HusseinDov GavishZvi VeredYoseph CaracoMazen 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FurukawaHiroshi SuginoRitsu TamuraToshiaki ManoMasaaki UematsuNoriaki UtsuKashima ItoTakuya HaraguchiKatsuhiko SatoYasunori UedaAkira NishibeKazuteru FujimotoMotomaru MasutaniAkira NishibeKazuteru FujimotoJung Han YoonSang-Hyun KimHack-Lyoung KimHun Sik ParkIn-Ho ChaeMoo Hyun KimMyung Ho JeongSeungwoon RhaChongjin KimHyo-Soo KimHae Young KimTaekjong HongSeung-Jea TahkYoungkwon KimArija BusmaneNatalija PontagaAldis StrelnieksIveta MintaleIveta SimeZaneta PetrulionieneRoma KavaliauskieneRuta JurgaitieneGintare SakalyteRimvydas SlapikasSigute NorkieneNerijus MisonisAleksandras KibarskisRaimondas KubiliusStojko BojovskiSasko KedevNensi LozanceAleksandar KjovkaroskiSnezana DoncovskaTiong Kiam OngSazzli KasimOteh MaskonBalachandran KandasamyKhalid YusoffHoung LiewWan Mohd Izani Wan MohamedArmando García CastilloGabriel Arturo Ramos LópezJorge Carrillo CalvilloPedro Fajardo CamposJuan Carlos Núñez FragosoEdmundo Alfredo Bayram LlamasMarco Antonio Alcocer GambaJaime Carranza MadrigalLuis Gerardo González SalasEnrique López RosasBelinda González DíazEduardo Salcido VázquezAlfredo Nacoud AckarGuillermo Antonio Llamas EsperónCarlos Rodolfo Martínez SánchezMaría Guerrero de LeonRodrigo Suarez OteroGuillermo Fanghänel SalmónJesús Antonio Pérez RíosJosé Angel Garza RuízMarco AlingsRobert BreedveldMargriet Feenema-AardemaAlida Borger-van der BurgPieter Am HoogslagHarry SuryapranataAntonius OomenPaulus van HaelstMargriet Feenema-ArademaJacobijne WiersmaDirk BasartRuud Ma van der WalPeter ZwartPascalle MonraatsHenricus van KesterenIoannis KaralisJohan JukemaGerardus Je VerdelBart Rg BruerenRoland Pth TroquayEric ViergeverNadea Yy Al-WindyGerard BartelsJan CornelWalter Rm HermansJohannes Pr HerrmanRobert BosReginald Gej GroutarsCoenraad van der ZwaanRefik KaplanEelko RonnerBjorn GroenemeijerPatrick Na BronzwaerAnho Ah LiemBernard Jwm RensingMarcel Jja BokernRemco NijmeijerFerry Mrj HersbachFrank WillemsAntonius Tm GosselinkSaman RasoulJohn ElliottGerard WilkinsRaewyn FisherDouglas ScottHamish HartRalph StewartScott HardingIan TernouthNicholas FisherSamuel WilsonDenise AitkenRussell AnscombeLaura DavidsonTadeusz TomalaOttar NygårdJon Arne SparbyKjell AndersenLars GullestadJarle JortveitPeter MunkErlend Gyllensten SingsaasSigrun HalvorsenUlf HurtigRoger Correa FloresJorge Calderon TiconaJulio Durand VelasquezSandra Negron MiguelEnrique Sanabria PerezJesus Carrion ChambillaCarlos Chavez AyalaReynaldo Castillo LeonRolando Vargas GonzalescJose Hernandez ZunigaLuis Camacho CosavalenteJorge Bravo MannucciJavier Heredia LandeoNassip Llerena NavarroYudy Roldan ConchaVíctor Rodriguez ChavezHenry Anchante HernandezCarlos Zea NunezWalter Mogrovejo RamosArthur FerrolinoRosa Allyn G SyLouie TiradorRody SyGeneroso MatigaRaul Martin CochingAlisa BernanGregorio RogelioDante MoralesEdgar TanDennis Jose SulitAdrian WlodarczakGrzegorz SkoniecznyLidia PawlowiczPawel WojewodaBenita Busz-PapiezJanusz BednarskiAleksander GochPawel StanetaElzbieta DulakAndrzej BudajKrzysztof SaminskiWlodzimierz KrasowskiWanda SudnikAleksander ZurakowskiMarcin SkorskiRoman LysekBeata MiklaszewiczJan Andrzej LipkoEdyta Kostarska-SrokoszMarek PiepiorkaAnna DrzewieckaArkadiusz StasiewskiTomasz BlicharskiLeszek BystrykMichal SzpajerMarek KorolTomasz CzerskiJacek GniotAndrzej LubinskiJerzy GornyEdward FranekGrzegorz RaczakHanna SzwedPedro MonteiroJose Mesquita BastosHelder PereiraJoao MoraisFilipe SeixoCarlos MendonçaAna BotelhoFrancisca CaetanoBogdan MinescuOctavian IstratoaieDan TesloianuMaria DorobantuGabriel CristianSilviu DumitrescuCristian Gc PodoleanuMircea Ca ConstantinescuCristina BengusConstantin MilitaruDoina RosuIrinel ParepaAdrian MateiTom AlexandruMihaela MalisIoan ComanYury ShvartsOlga OrlikovaZhanna KobalavaOlga BarbarashValentin MarkovNadezhda LyaminaAlexander GordienkoKonstantin ZrazhevskyAlexander VishnevskyVictor GurevichRaisa StryukNikita LomakinIgor BokarevTatiana KhlevchukSergey ShalaevLarisa KhaishevaPetr ChizhovInna ViktorovaNatalya OsokinaVladimir ShchekotovEvgenia AkatovaGalina ChumakovaIgor LibovMikhail VoevodaTatyana TretyakovaEvgeny BaranovSergey ShustovSergey YakushinIvan GordeevNiiaz KhasanovOlga ReshetkoTatiana SotnikovaOlga MolchanovaKonstantin NikolaevLiudmila GaponElena BaranovaElena KosmachovaYuriy KarpovYuri KarpovAnton PovzunLiudmila EgorovaVadim TyrenkoIgor IvanovMasterov IlyaSergey KanorskyDragan SimicNikola IvanovicGoran DavidovicNebojsa TasicMilika AsaninStevo StojicSvetlana ApostolovicStevan IlicBiljana Putnikovic TosicAleksandar StankovicAleksandra ArandjelovicSlavica RadovanovicBranislava TodicArsen RisticJovan BalinovacDragan DincicPetar SeferovicAna KaradzicSlobodan DodicSinisa DimkovicTamara JakimovKian-Keong PohHean Yee OngJustin Tang I-ShingKarol MickoJan NociarDaniel PellaPeter FulopMarian HranaiJuraj PalkaJuraj MazurIvan MajercákAndrej DzupinaFrantišek FazekasJozef GonsorcikViliam BuganJan MurinJuraj SeleckyGabriel KamenskyJaroslava StrbovaRudolf SmikAndrej DukatPeter OlexaIvan 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BenedictoCarlos Gonzalez-JuanateyMercedes Camprubí PotauIgnacio Plaza PerezCésar Morís de la TassaPablo Loma-Osorio RinconJavier Balaguer RecenaJuan EscudierAntonio Coca PayerasNorberto Alonso OrcajoGodwin ConstantineRuvaiz HaniffaNirmali TisseraStanley AmarasekeraChandrike PonnamperumaNimali FernandoKaputella FernandoJayanthimala JayawardenaSantharaj WijeyasingamGotabhaya RanasingheRuvan EkanayakaSepalika MendisVajira SenaratneGnanamoorthy MayurathanAjantha RajapakshaThilak SirisenaJagath HerathNaomali AmarasenaStefan BerglundGundars RasmanisEmil HagströmOla VedinNils WittGeorgios MourtzinisPeter NicolOle HansenStefano RomeoSteen Agergaard JensenIngemar TorstenssonUlf AhremarkTorbjörn SundelinTiziano MoccettiChristian MüllerFrancois MachRonald BindeUlf LandmesserOliver GämperliChern-En ChiangWei- Chuan TsaiKwo-Chang UengWen-Ter LaiMing-En LiuJuey- Jen HwangWei-Hsian YinI-Chang HsiehMing-Jer HsiehWei Hsiang LinJen-Yuan KuoTsuei-Yuan HuangChih-Yuan FangPinij KaewsuwannaWasant SoonfuangWoravut JintapakornApichard SukonthasarnPiyamitr SritaraNattawut WongpraparutKrisada SastravahaNakarin SansanayudhWirash KehasukcharoenDilok PiyayotaiPaiboon ChotnoparatpatAhmet CamsariHakan KultursaySema GuneriBulent MutluMurat ErsanliMustafa DemirtasCevat KirmaErtan UralLale KoldasOleksandr KarpenkoAlexander ProkhorovIhor VakaluykHalyna MyshanychDmytro ReshotkoValeriy BatushkinLeonid RudenkoIhor KovalskyiMykola KushnirVira TseluykoYuriy MostovoyMykola StanislavchukYulian KyiakYuriy KarpenkoYaroslav MalynovskyAndriy KlantsaOles KutniyEkaterina AmosovaViktor TashchukOleh LeshchukAlexander ParkhomenkoMykola RishkoMykola KopytsyaAndriy YagenskyMykola VatutinAndriy BagriyOlga BarnaOlexiy UshakovGeorgiy DzyakBorys GoloborodkoAnatolii RudenkoVolodymyr ZheleznyyJasper TrevelyanAzfar ZamanKaeng LeeAndrew MoriartyRajesh AggarwalPiers CliffordYuk- Ki WongSyed Mr IqbalEduardas SubkovasDenise BraganzaDavid SarkarRobert StoreyHuw GriffithsSam McclureRangasamy MuthusamySimon SmithJohn KurianTerry LevyCraig BarrHoner KadrRobert GerberAudrius SimaitisHandrean SoranAdrian BrodisonMohammad AyazMuhammad CheemaRichard OliverSimon ThackrayTelal MudawiGohar RahmaAyyaz SultanTimothy ReynoldsDavid SharmanDavid SprigingRob ButlerPeter WilkinsonGregory Yh LipNicholas Ossei-GerningGil VardiDuccio BaldariDavid BrabhamCharles Treasure IiCharles DahlBruce PalmerAlan WisemanAbul KhanSanjeev PuriAnn Elizabeth MohartCarlos InceEnrique FloresScott WrightShi-Chi ChengMichael RosenbergWilliam RogersEdward KosinskiLes ForgoshJonathan WaltmanMohammad ShoukfehGeorges DagherPatrick CambierIra LieberPriya KumarCara EastPerry KrichmarMian HasanLindsey WhiteThomas KnickelbineThomas HaldisEve GillespieThomas AmidonDavid SuhImran ArifMouhamad AbdallahFaiq AkhterEric CarlsonMichael D’ursoFadi El- AhdabWilliam NelsonKatie MoriartyBarry HarrisSteven CohenLuther CarterDaniel DotyKenneth SabatinoTariq HaddadSunder RaoAngel MulkayIon JovinKim KlanckeVinay MalhotraSai DevarapalliMichael KorenHarish ChandnaGeorge Dodds IiiTauqir GorayaJames BengstonMatthew JanikJoseph MoranAndrew SumnerJohn KobayashiWilliam DavisShahram YazdaniJohn PasquiniMaitreya ThakkarAmarnath VedereWayne LeimbachJames RiderSarah FentonNarendra SinghAnil ShahPatrick MoriartyDenise JanosikCarl PepineBrett BermanJoseph GelorminiChristopher DanielsKerensky RichardFriederike KeatingNicholas KondoSanjay ShettyHoward LeviteWinfried WaiderTheodore TakataMazen Abu-FadelVipul ShahRahul AggarwalAnil KumarBrack HattlerRose DoChad LinkAnna BortnickGeorge Kinzfogl IiiArnold GhitisJohn LarryEdward TeufelPeter KuhlmanBrent MclaurinWenwu ZhangStephen ThewJalal AbbasMatthew WhiteOthman IslamSumeet SubherwalNandkishore RanadiveBabak VakiliChristian GringDavid HendersonTimothy SchuchardNaim FarhatGeoffrey KlineSharan MahalJack WhitakerShawn SpeirsRolf AndersenNizar DaboulPhillip HorwitzFiras ZahrGeorge PonceZubair JafarJoseph McgarveyVipul PanchalStephen VoyceThomas BlokWilliam SheldonMasoud AzizadCarsten SchmalfussMark PiconeRobert PedersonWilliam HerzogKeith FriedmanJason LindseyEichenlaub TimothyParilak LeonardNorman LeporMahfouz El ShahawyHoward WeintraubAnand IrimpenAlvaro AlonsoWade MayDaniels ChristopherThomas GalskiAlan ChuFreny ModyEbrahimi RaminZachary HodesJoseph RossiGregory RoseJames FairlambCharles LambertAjit RaisinghaniAntonio AbbateGeorge VetrovecMarilyn KingCharles CareyJaime GerberLiwa YounisMladen VidovichThomas KnutsonDennis FriedmanFred ChaleffArthur LoussararianPhillip RozemanCarey KimmelstielJeffrey KuvinKevin SilverMalcolm FosterGlen TonnessenAndrey EspinozaMohamadali AmlaniAndreas WaliChristopher MalozziGeert JongClara MasseyKeattiyoat WattanakitPhilip O’donnellDinesh SingalNaseem JaffraniSridhar BanuruDaniel FisherMark XenakisNeal PerlmutterRavi BhagwatJames StraderRonald BlonderAyim Akyea-DjamsonAjay LabrooKwan LeeH. John MaraisEdmund ClaxtonRobert WeissRohr KathrynMartin BerkPeter RossiParag JoshiAmit KheraAjit KhairaGreg KumkumianSteven LupovitchJoshua PurowStephen WelkaDavid HoffmanStuart FischerEugene SorokaDonald EagertonSamir PancholyMichael RayNorman ErenrichMichael FarrarStewart PollockWilliam FrenchSteve DiamantisDouglas GuyLawrence GimpleMark NeustelSteven SchwartzEdward PereiraSeals AlbertDouglas SpriggsJanet StrainSuneet MittalAnthony VoMajed ChaneJason HallNampalli VijayKapildeo LotunF. Martin LesterAhed NahhasTheodore PopePaul NagerRakesh VohraMukesh SharmaRiyaz BashirHinan AhmedMichael BerlowitzRobert FishbergRobert BarruccoEric YangMichael RadinDaniel SpornDwight StapletonSteven EisenbergJoel LandzbergMartin McgoughSamir TurkMichael SchwartzP. Sandy SundramDiwakar JainMark ZaineaCarlos BayronRonald KarlsbergSuhail DohadHenry LuiWilliam KeenDonald WesterhausenSandeep KhuranaHimanshu AgarwalJessica BirchemWilliam PennyMark ChangSherrill MurphyJohn HenryBranislav SchifferdeckerJohn GilbertGopal ChalavaryaCharles EatonJohn SchmedtjeStuart ChristensonImran DotaniDouglas DenhamAlexander MacdonellJohn Paul GibsonAref RahmanTammam Al JoundiNizar AssiGary ConradPurushotham KothaMichael LoveGregory GieslerHoward RubensteinDawood GamilLaura AkrightJustine KrawczykJoanne CoblerTerry WellsJames WelkerRobert FosterRichard GilmoreJay AndersonDouglas JacobyBill HarrisGeraldine GardnerRamprasad DandillayaKishor VoraJohn KostisJohn HunterDavid LaxsonEric BallJay AndersonTerry WellsKishor VoraEric BallJames WelkerRenato LopesFlavia EgydioAnelise KawakamiJanaina OliveiraShaun GoodmanJulianna WozniakAlexander MatthewsCaroline RatkyJanine ValirisLisa BerdanAnita HepditchKirby QuinteroMatthew RoeTyrus RorickMelissa WestbrookNicolas DanchinMadeleine BezaultElodie DrouetTabassome SimonHarvey WhiteCaroline AlsweilerPeter SinnaeveAnne LuytenPhilip AylwardJulie ButtersLiddy GriffithMichelle ShawEmil HagströmLena GrunbergMichael SzarekShahidul IslamMarie-France BrégeaultNathalie BougonDouglas FaustinoSylvie FontecaveJudith MurphyJean- Francois TambyMelanie VerrierVeronique AgnettiDorthe AndersenEmmy BadreddineMhamed BekkoucheCecile BouancheauImane BriguiMaddy BrocklehurstJoseph CianciaruloDawn DevaulSzilvia DomokosCecile GacheCaroline GobillotSeverine GuillouJan HealyMegan HeathGayatri JaiwalCarine JavierreJulien LabeirieMyriam MonierUlises MoralesAsmaa MrabtiBicky MthombeniBetim OkanLucile SmithJennifer ShellerSebastien SopenaValerie PellanFadela BenbernouNafissa BengraitMaud LamoureuxKatarina KralovaMichel ScemamaRaphael BejuitAnthony CoulangeChristelle BerthouJérôme RepincayChristelle LorenzatoAlexis EtienneValerie GouetGuillaume LecorpsVirginie LoizeauMickael NormandAnne OurliacChristelle RondelAntony AdamoPascale BeltranPauline BarraudHelene Dubois-GacheBenjamin HalleLamia MetwallyMaxime MourguesMarc SottyMarion VincendetRaluca CotrutaZhu ChengyueDominique Fournie-LloretChristine MorrelloAurelie PerthuisPatrick PicaultIsabelle ZobouyanHelen ColhounMichael DempseyMark Mcclanahan
• Organismes : Laboratoire de Recherche Vasculaire Translationnelle
• Publié dans Circulation le 29/10/2020

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Résumé : Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score–matched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9–3.6], 4.0 [95% CI, 3.6–4.5], and 5.5 [95% CI, 5.0–6.1] events per 100 patient-years in strata <75, 75–<90, ≥90 mg/dL, respectively; P trend <0.0001) and after adjustment for low-density lipoprotein cholesterol ( P trend =0.035). Higher baseline apoB stratum was associated with greater relative ( P trend <0.0001) and absolute reduction in MACE with alirocumab versus placebo. In the alirocumab group, the incidence of MACE after month 4 decreased monotonically across decreasing achieved apoB strata (4.26 [95% CI, 3.78–4.79], 3.09 [95% CI, 2.69–3.54], and 2.41 [95% CI, 2.11–2.76] events per 100 patient-years in strata ≥50, >35–<50, and ≤35 mg/dL, respectively). Compared with propensity score–matched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as ≤35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/08/2022
• Auteurs : Philippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal

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• Type de publi. : Article dans une revue
• Date de publi. : 29/08/2022
• Auteurs : Daria Kartasheva-EbertzJesintha GastonLoriane Lair-MehiriEstelle MottezTan-Phuc BuivanPierre-Philippe MassaultOlivier ScattonSebastien GaujouxJean-Christophe VaillantStanislas PolSylvie Lagaye
• Organismes : Immunobiologie des Cellules dendritiques Université Paris Cité Immunobiologie des Cellules dendritiques Université Paris Cité Université Paris Cité Département d'hépatologie [CHU Cochin] Centre de Recherche Translationnelle - Center for Translational Science Centre de Recherche Translationnelle - Center for Translational Science Hôpital Cochin [AP-HP] Université Paris Cité CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Immunobiologie des Cellules dendritiques Université Paris Cité Département d'hépatologie [CHU Cochin] Immunobiologie des Cellules dendritiques Centre de Recherche Saint-Antoine
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : IL-17A is considered to guide liver inflammation and fibrosis. From twenty-two human liver samples of different fibrosis stages (F0 to F4), IL-17A, IL-22, and TGFβ1 protein expression in liver tissue lysates were analyzed. Ten paired samples of liver tissue (F0–F1 stage) and blood from the same patient were used to analyze intrahepatic and blood T-lymphoid IL-17A+ cells by flow cytometry. The analyses have been performed regardless of pathology, considering the stage of fibrosis. Human liver tissue was used for the primary human liver slice cultures, followed by subsequent cytokine stimulation and fibrotic markers’ analysis by ELISA. IL-17A production in human liver tissue was significantly higher in the early fibrotic stage compared with the advanced stage. Th17 T cells and, to a lesser extent, MAIT cells were the main sources of IL-17A in both compartments, the liver and the blood. Moreover, the presence of liver Th17IL-17A+INFγ+ cells was detected in the liver. IL-17A stimulation of human liver slice culture increased the expression of profibrotic and pro-inflammatory markers. IL-17A, secreted by Th17 and MAIT cells in the liver, triggered fibrosis by inducing the expression of IL-6 and profibrotic markers and could be a target for antifibrotic treatment. Further amplitude studies are needed to confirm the current results.

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Fichiers liés : ijms-23-09773 (1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/08/2022
• Auteurs : Gianpiero TagliaferriAngelo AntonelliTora ArnesenJann AscherslebenPrimo AttinaMatteo BalboSunghyun BangMiquel BarceloAndrey BaryshevGiancarlo BellassaiDavid BergeChris BicknellCiro BigongiariGiacomo BonnoliFrederic BouleyAnthony BrownAndrea BulgarelliMassimo CappiPatrizia CaraveoSalvatore CascheraPaula ChadwickFrancesco ConteGarret CotterPierre CristofariFatima de FrondatElisabete de Gouveia Dal PinoNico de SimoneDavide DepaoliJean Laurent DournauxConnor DuffySabrina EineckeCarlos FerminoStefan FunkCarmelo GarganoGianluca GiavittoAndrea GiulianiTim GreenshawJim HintonJean-Michel HuetSimone IovenittiNicola La PalombaraJon LapingtonPhilippe LaporteSteve LeachLuigi LessioGiuseppe LetoSheridan LloydFabrizio LucarelliSaverio LombardiAlberto MacchiEugenio MartinettiAntonio MiccicheRachele MillulTeresa MineoTakahashi MitsunariAmrit NayakGaetano NicotraAkira OkumuraGiovanni PareschiMarek PennoHeike ProkophEmma RebertChiara RighiCameron RultenFederico RussoRicardo Zanmar SanchezFrancesco SaturniJohannes SchaeferBenni SchwabSalvatore ScuderiGiorgia SironiVitalii SliusarHelene SolSamuel SpencerAntonio StamerraHiro TajimaFabrizio TavecchioGino TostiAlessio TroisManuela VecchiStefano VercelloneJacco VinkRoland WalterJason WatsonRichard WhiteRoberta ZaninLuca ZampieriAndreas ZechAdrian Zink
• Organismes : Laboratoire Univers et Théories
• Publié dans Proceedings of SPIE, the International Society for Optical Engineering le 09/05/2016

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• Type de publi. : Article dans une revue
• Date de publi. : 27/08/2022
• Auteurs : Alexy Tran-DinhDonia BouzidAdnan El KalaiEnora AtchadeSébastien TanakaBrice Lortat-JacobSylvain Jean-BaptisteNathalie ZappellaSandrine BoudinetYves CastierHervé MalPierre MordantJonathan MessikaPhilippe Montravers
• Organismes : AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Diabète athérothrombose et thérapies Réunion Océan Indien AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris]
• Publié dans BMC Pulmonary Medicine le 22/10/2020

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Résumé : Introduction The maximum gain in quality of life after lung transplantation (LT) is expected between six months and one year after LT, as the occurrence of chronic lung allograft dysfunction may mask the beneficial effects beyond one year. Thus, the postoperative period could be the cornerstone of graft success. We sought to describe the factors present before postoperative admission to the ICU and associated with favorable, arduous or fatal pathway within 90 days of LT. Materials and methods We conducted a retrospective single-center study between January 2015 and December 2020. Using multinomial regression, we assessed the demographic, preoperative and intraoperative characteristics of patients associated with favorable (duration of postoperative mechanical ventilation < 3 days and alive at Day 90), arduous (duration of postoperative mechanical ventilation ≥ 3 days and alive at Day 90) or fatal (dead at Day 90) pathway within 90 days of LT. Results A total of 269 lung transplant patients were analyzed. Maximum graft cold ischemic time ≥ 6 h and intraoperative blood transfusion ≥ 3 packed red blood cells were associated with arduous and fatal pathway at Day 90, whereas intraoperative ECMO was strongly associated with fatal pathway. Conclusion No patient demographics influenced the postoperative pathway at Day 90. Only extrinsic factors involving graft ischemia time, intraoperative transfusion, and intraoperative ECMO determined early postoperative pathway.

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• Type de publi. : Article dans une revue
• Date de publi. : 26/08/2022
• Auteurs : Saïd NouiraCharles Pierre BlancPierre-André CrochetThierry FréteyPhilippe GeniezIvan IneichJean-Christophe de MassaryAnnemarie OhlerWided TliliJean Lescure
• Organismes : Département des Sciences Biologiques, Faculté des Sciences de Tunis Centre d’Ecologie Fonctionnelle et Evolutive Association RACINE Centre d’Ecologie Fonctionnelle et Evolutive Institut de Systématique, Evolution, Biodiversité Patrimoine naturel Institut de Systématique, Evolution, Biodiversité Département des Sciences Biologiques, Faculté des Sciences de Tunis Institut de Systématique, Evolution, Biodiversité
• Publié dans Bulletin de la Société Herpétologique de France le 26/10/2020

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Résumé : Une nouvelle liste taxinomique de référence est établie pour les Amphibiens et les « Reptiles » de la Tunisie. À côté du nom scientifique zoologique international, un nom scientifique français est joint à chaque taxon. L'herpétofaune tunisienne compte actuellement sept espèces d' Amphibiens et 62 de « Reptiles ».

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Fichiers liés : N180_ART_Nouira-et-al.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/08/2022
• Auteurs : Alexandre FauchéEmilie PreslesOlivier SanchezXavier JaïsRaphael Le MaoPhilippe RobinGilles PernodLaurent BertolettiPatrick JegoFlorence ParentCatherine A. LemariéFlorent LevenPierre-Yves Le RouxPierre-Yves SalaunMichel NonentPhilippe GirardKarine LacutLaurent SavaleSolen MélacMarie GuéganPatrick MismettiSilvy LaporteChristophe LeroyerDavid MontaniFrancis CouturaudCécile Tromeur
• Organismes : Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Hôpital Européen Georges Pompidou [APHP] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes Santé Ingénierie Biologie Saint-Etienne F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] Université de Rennes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Institut Mutualiste de Montsouris F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne]
• Publié dans Journal of Thrombosis and Haemostasis le 27/10/2020

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Résumé : Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary embolism's (PE) complication whose incidence and predictors are not precisely determined. Objective: To determine the frequency and predictors for CTEPH after a first unprovoked PE. Patients/methods: In a randomized trial comparing an additional 18-month warfarin versus placebo in patients after a first unprovoked PE initially treated with vitamin K antagonist for 6 months, we applied recommended CTEPH screening strategies through 8-year follow-up to determine cumulative incidence of CTEPH. CTEPH predictors were estimated using Cox models. Pulmonary vascular obstruction (PVO) and systolic pulmonary arterial pressure (sPAP) at PE diagnosis and 6 months were studied by receiver operating curves analysis. All CTEPH cases and whether they were incident or prevalent were adjudicated. Results: During a median follow-up of 8.7 years, 9 CTEPH cases were diagnosed among 371 patients, with a cumulative incidence of 2.8% (95% confidence interval [CI], 0.95-4.64), and of 1.31% (95%CI, 0.01-2.60) after exclusion of 5 cases adjudicated as prevalent. At PE diagnosis, PVO>45% and sPAP>56mmHg were associated with CTEPH with a hazard ratio (HR) of 33.00 (95%CI 1.64-667.00, p=0.02) and 12.50 (95%CI 2.10-74.80, p<0.01) respectively. Age>65 years, lupus anticoagulant antibodies and non-O blood groups were also predictive of CTEPH. PVO>14% and sPAP>34mmHg at 6-month were associated with CTEPH (HRs 63.90 [95%CI, 3.11-1310.00, p<0.01]and 17.2 [95%CI, 2.75-108, p<0.01]). Conclusion: After a first unprovoked PE, CTEPH cumulative incidence was 2.8% during 8-year follow-up. PVO and sPAP at PE diagnosis and at 6 months were the main predictors for CTEPH diagnosis.

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Fichiers liés : Fauché et al. - 2022 - Frequency and Predictors for Chronic Thromboemboli.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 24/08/2022
• Auteurs : Sheela RaoMark JonesJill BowmanChuan TianJean-Philippe Spano
• Organismes : Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Frontiers in Oncology le 26/10/2020

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Résumé : Background Squamous carcinoma of the anal canal (SCAC) is a human papillomavirus (HPV)-driven cancer with poor prognosis in locally advanced or recurrent settings. Carboplatin–paclitaxel is the preferred first-line regimen for unresectable locally advanced or metastatic SCAC, with the reported median progression-free survival (PFS) and overall survival (OS) of 8.1 and 20.0 months, respectively. Immune checkpoint blockade (ICB) demonstrates improved survival in HPV-driven cervical and head and neck cancers. Retifanlimab (INCMGA00012) is an investigational humanized, hinge-stabilized, immunoglobulin G4κ monoclonal antibody targeting programmed cell death-1 (PD-1), with characteristics common to the ICB class. In POD1UM-202, retifanlimab showed substantial clinical activity and an expected safety profile in patients with advanced SCAC who progressed on platinum-based chemotherapy. Based on these encouraging results, POD1UM-303/InterAACT 2 (NCT04472429), a phase III, double-blind, randomized, multiregional study, investigates the addition of retifanlimab to the standard of care (SOC) carboplatin–paclitaxel in patients with inoperable locally recurrent or metastatic SCAC not previously treated with systemic chemotherapy. Methods and analysis Patients ≥18 years with inoperable locally recurrent or metastatic SCAC, measurable disease per RECIST v1.1, and no prior systemic chemotherapy or PD-(L)1-directed therapy will be enrolled and stratified by PD-L1 expression, region, and extent of disease. Patients with well-controlled human immunodeficiency virus infection are eligible. Planned enrollment is approximately 300 patients worldwide, with a 1:1 randomization to retifanlimab or placebo. Patients will receive up to six induction cycles (24 weeks) of carboplatin (area-under-the-curve 5 on day 1) and paclitaxel (80 mg/m 2 on days 1, 8, and 15) every 28 days per SOC. Concurrently, retifanlimab 500 mg or placebo will be administered intravenously in a blinded fashion on day 1 of each 28-day cycle for up to 13 cycles (1 year) in the absence of unacceptable toxicity, disease progression, withdrawal of consent, loss to follow-up, or premature discontinuation. Crossover to open-label retifanlimab will be allowed for patients assigned to placebo upon verification of progression by blinded independent central radiographic review (BICR). The primary study endpoint is PFS per RECIST v1.1 by BICR. Secondary endpoints are OS, objective response rate, duration of response, disease control rate, safety, and retifanlimab pharmacokinetics. The study is currently recruiting. Clinical Trial Registration https://clinicaltrials.gov/ct2/show/NCT04472429 ; https://clinicaltrialsregister.eu/ctr-search/search?query=2020-000826-24

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Fichiers liés : A phase III, global, randomized, double-blind study of retifanlimab or placebo plus carboplatin-paclitaxel in patients with locally advanced or metastatic squamous cell anal carcinoma..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/08/2022
• Auteurs : Geoffrey AvisYann GricourtPierre Baptiste VialatteVictor MeunierMikael PerinNatacha SimonPierre-Geraud ClaretHassan El FertitJean-Yves LefrantMartin M. BertrandPhilippe Cuvillon
• Organismes : Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire de Nîmes Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Universitaire de Nîmes Unité de réanimation médicale [CHU de Carémeau, Nîmes] Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts
• Publié dans Regional Anesthesia and Pain Medicine le 28/10/2020

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Résumé : Introduction: Erector spinae plane block has been proposed to reduce opioid use and improve pain relief with controversial results. This randomized clinical study aimed to assess the efficacy of erector spinae plane block in major spine surgery including multimodal and 'Enhance Recovery After Surgery' programs. Method: After institutional review board approval, adult patients undergoing elective lumbar spine surgery with standardized general anesthesia, rehabilitation and multimodal analgesia protocols were randomly allocated to receive bilateral ultrasound-guided block with saline versus ropivacaine (3.75 mg/mL). Before surgery, a bilateral erector spinae plane block was performed at lumbar level (third vertebrae) with 20 mL of solution for each side. The primary outcome was morphine consumption after 24 hours. Secondary outcomes included pain scores and side effects, from postanesthesia care unit to discharge, and questionnaires at 3 months on pain and quality of life (EQ-5D). Results: From November 2019 to July 2021, 50 patients were enrolled with similar characteristics and surgery for each group. After the first 24 hours, there was no statistical difference regarding cumulative intravenous morphine consumption between ropivacaine and saline groups: 7.3 mg (3.7-19) vs 12.5 mg (3.5-26) (p=0.51). Over the five postoperative days, opioid sparing, pain scores and side effects were similar between groups. At 3 months, pain relief, incidence of chronic pain and EQ-5D were similar between groups. Discussion: Erector spinae plane block used in conjunction with 'Enhance Recovery After Surgery' and multimodal analgesia protocols provides limited reduction in opioid consumption and no long-term benefits. Trial registration number: EudraCT 2019-001678-26.

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• Type de publi. : Article dans une revue
• Date de publi. : 20/08/2022
• Auteurs : Thomas SchmitzMuriel Doret-DionLoic SentilhesOlivier ParantOlivier ClarisLaurent RenesmeJulie AbbalAude GiraultHéloïse TorchinMarie HoullierNolwenn Le SachéAlexandre VivantiDaniele de LucaNorbert WinerCyril FlamantClaire ThuillierPascal BoileauJulie BlancVéronique BrevautPierre-Emmanuel BouetGéraldine GascoinGaël BeucherValérie Datin-DorriereStéphane BounanPascal BolotChristophe PonceletCorinne AlbertiMoreno UrsinoCamille AupiaisOlivier BaudPhilippe BoizeCharles GarabédianFlorence FlameinMaela Le LousAlain BeuchéeJean GondryPierre TourneuxPerrine Coste-MazeauAntoine BeduDenis GallotKaren CosteCéline ChauleurHugues PaturalGilles KayemDelphine MitanchezHélène HeckenrothFarid BoubredJeanne SibiudeLuc DesfrèreCaroline BohecThierry MansirAntoine KochPierre KuhnNadia TilloucheFabrice LapeyreFranck PerrotinGéraldine FavraisEdouard LecarpentierXaxier DurrmeyerVéronique EquyThierry DebillonLuc RigonnotStéphanie LefoulgocClaudia BrieAnne-Sophie PagèsRomy RayssiguierGilles CambonieCorinne CudevilleDoriane MadeleneauOlivier MorelJean-Michel HascoetVincent LetouzeyMassimo Di MaioLaurent SalomonAlexandre Lapillonne
• Organismes : Hôpital Robert Debré Hôpital Femme Mère Enfant [CHU - HCL] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Toulouse Hospices Civils de Lyon Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Centre Hospitalier Universitaire de Toulouse Maternité Port-Royal [CHU Cochin] AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] AP-HP - Hôpital Antoine Béclère [Clamart] Service de Pédiatrie et Réanimations néonatales [Béclère] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Physiopathologie des Adaptations Nutritionnelles Physiopathologie des Adaptations Nutritionnelles CHI Poissy-Saint-Germain Physiologie et physiopathologie endocriniennes CHI Poissy-Saint-Germain École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville Education, Formation, Travail, Savoirs Hôpital Nord [CHU - APHM] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier René Dubos [Pontoise] Hôpital Robert Debré Paris Centre de Recherche des Cordeliers Health data- and model- driven Knowledge Acquisition Centre d'Investigation Clinique 1426 Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables Maladies neurodéveloppementales et neurovasculaires CHU Amiens-Picardie Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 UPJV Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Soins Intensifs de Néonatologie et Médecine Néonatale / Réanimation et Surveillance Continue de Pédiatrie [CHU Amiens]
• Publié dans The Lancet le 02/11/2020

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Résumé : Background: Antenatal betamethasone is recommended before preterm delivery to accelerate fetal lung maturation. However, reports of growth and neurodevelopmental dose-related side-effects suggest that the current dose (12 mg plus 12 mg, 24 h apart) might be too high. We therefore investigated whether a half dose would be non-inferior to the current full dose for preventing respiratory distress syndrome. Methods: We designed a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial in 37 level 3 referral perinatal centres in France. Eligible participants were pregnant women aged 18 years or older with a singleton fetus at risk of preterm delivery and already treated with the first injection of antenatal betamethasone (11·4 mg) before 32 weeks' gestation. We used a computer-generated code producing permuted blocks of varying sizes to randomly assign (1:1) women to receive either a placebo (half-dose group) or a second 11·4 mg betamethasone injection (full-dose group) 24 h later. Randomisation was stratified by gestational age (before or after 28 weeks). Participants, clinicians, and study staff were masked to the treatment allocation. The primary outcome was the need for exogenous intratracheal surfactant within 48 h after birth. Non-inferiority would be shown if the higher limit of the 95% CI for the between-group difference between the half-dose and full-dose groups in the primary endpoint was less than 4 percentage points (corresponding to a maximum relative risk of 1·20). Four interim analyses monitoring the primary and the secondary safety outcomes were done during the study period, using a sequential data analysis method that provided futility and non-inferiority stopping rules and checked for type I and II errors. Interim analyses were done in the intention-to-treat population. This trial was registered with ClinicalTrials.gov, NCT02897076. Findings: Between Jan 2, 2017, and Oct 9, 2019, 3244 women were randomly assigned to the half-dose (n=1620 [49·9%]) or the full-dose group (n=1624 [50·1%]); 48 women withdrew consent, 30 fetuses were stillborn, 16 neonates were lost to follow-up, and 9 neonates died before evaluation, so that 3141 neonates remained for analysis. In the intention-to-treat analysis, the primary outcome occurred in 313 (20·0%) of 1567 neonates in the half-dose group and 276 (17·5%) of 1574 neonates in the full-dose group (risk difference 2·4%, 95% CI -0·3 to 5·2); thus non-inferiority was not shown. The per-protocol analysis also did not show non-inferiority (risk difference 2·2%, 95% CI -0·6 to 5·1). No between-group differences appeared in the rates of neonatal death, grade 3-4 intraventricular haemorrhage, stage ≥2 necrotising enterocolitis, severe retinopathy of prematurity, or bronchopulmonary dysplasia. Interpretation: Because non-inferiority of the half-dose compared with the full-dose regimen was not shown, our results do not support practice changes towards antenatal betamethasone dose reduction.

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