Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Delphine VivierMarie HautièreDonovan PineauPierre-Alix DancerAmaury HerbetJean-Philippe HugnotClaire BernhardVictor GoncalvesCharles TruilletDidier BoquetFranck Denat
• Organismes : Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Institut de Génomique Fonctionnelle Kaerlabs Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Institut de Génomique Fonctionnelle Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay Médicaments et Technologies pour la Santé Service de Pharmacologie et Immunoanalyse Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
• Publié dans Bioconjugate Chemistry le 28/10/2020

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Résumé : For the past two decades, the emerging role of the endothelin (ET) axis in cancer has been extensively investigated, and its involvement in several mechanisms described as “hallmarks of cancer” has clearly highlighted its potential as a therapeutic target. Despite the growing interest in finding effective anticancer drugs, no breakthrough treatment has successfully made its way to the market. Recently, our team reported the development of a new immuno-positron emission tomography probe targeting the ET A receptor (ETA, one of the ET receptors) that allows the successful detection of ETA+ glioblastoma, paving the way for the elaboration of novel antibody-based strategies. In this study, we describe the synthesis of two PET/NIRF (positron emission tomography/near-infrared fluorescence) dually functionalized imaging agents, directed against ETA or ETB, that could be used to detect ET+ tumors and select patients that will be eligible for fluorescence-guided surgery. Both imaging modalities were brought together using a highly versatile tetrazine platform bearing the IRDye800CW fluorophore and desferrioxamine for 89Zr chelation. This so-called monomolecular multimodal imaging probe was then “clicked”, via an inverse-electron-demand Diels–Alder reaction, to antibodies conjugated site-specifically with a trans-cyclooctene group. This approach has led to homogeneous and well-defined constructs that retained their high affinity and high specificity for their respective target, as shown by flow cytometry and NIRF in vivo imaging experiments in nude mice bearing CHO-ETA and CHO-ETB tumors. Ultimately, these bimodal immunoconjugates could be used to improve the outcomes of patients with ET+ tumors.

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Fichiers liés : Manuscript_revised.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Vincent CottinPhilippe BonniaudJacques CadranelBruno CrestaniStéphane JouneauSylvain Marchand-AdamHilario NunesLidwine Wémeau-StervinouEmmanuel BergotElodie BlanchardRaphaël BorieArnaud BourdinCécile ChenivesseAnnick ClémentEmmanuel GomezAnne GondouinSandrine HirschiFrançois LebargyCharles-Hugo MarquetteDavid MontaniGrégoire PrévotSébastien QuetantMartine Reynaud-GaubertMathieu SalaunOlivier SanchezBruno TrumbicKarim BerkaniPierre Yves BrilletMarion CampanaLara ChalabreysseGérard ChattéDidier DebieuvreGilbert FerrettiJean-Michel FourrierNicolas JustMarianne KambouchnerBertrand LegrandFrédéric Le GuillouJean-Pierre LhuillierAnas MehdaouiJean-Marc NaccacheCatherine PaganonMartine Rémy-JardinSalim Si-MohamedPhilippe Terrioux
• Organismes : Infections Virales et Pathologie Comparée - UMR 754 Centre national de référence des maladies pulmonaires rares [Lyon] Lipides - Nutrition - Cancer [Dijon - U1231] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Service de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon] CHU Tenon [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Centre Hospitalier Régional Universitaire de Tours Hôpital Avicenne [AP-HP] Institut Coeur Poumon [CHU Lille] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Pessac AP-HP - Hôpital Bichat - Claude Bernard [Paris] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 Maladies génétiques d'expression pédiatrique Centre Hospitalier Régional Universitaire de Besançon Nouvel Hôpital Civil de Strasbourg Hôpital universitaire Robert Debré [Reims] Hôpital Pasteur [Nice] Institut de Recherche sur le Cancer et le Vieillissement Hypertension pulmonaire : physiopathologie et innovation thérapeutique Centre Hospitalier Universitaire de Toulouse CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU Marseille Microbes Evolution Phylogénie et Infections Centre d'Investigation Clinique [CHU Rouen] Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes Hôpital Européen Georges Pompidou [APHP] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Centre Hospitalier Régional d'Orléans Hospices Civils de Lyon Centre Hospitalier Emile Muller [Mulhouse] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Hôpital Avicenne [AP-HP] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Centre Hospitalier Eure-Seine - Hôpital d'Evreux et de Vernon Groupe Hospitalier Paris Saint-Joseph Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie Institut Coeur Poumon [CHU Lille] Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
• Publié dans Respiratory Medicine and Research le 28/10/2020

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Résumé : BACKGROUND: Since the previous French guidelines were published in 2017, substantial additional knowledge about idiopathic pulmonary fibrosis has accumulated. METHODS: Under the auspices of the French-speaking Learned Society of Pulmonology and at the initiative of the coordinating reference center, practical guidelines for treatment of rare pulmonary diseases have been established. They were elaborated by groups of writers, reviewers and coordinators with the help of the OrphaLung network, as well as pulmonologists with varying practice modalities, radiologists, pathologists, a general practitioner, a head nurse, and a patients’ association. The method was developed according to rules entitled "Good clinical practice" in the overall framework of the "Guidelines for clinical practice" of the official French health authority (HAS), taking into account the results of an online vote using a Likert scale. RESULTS: After analysis of the literature, 54 recommendations were formulated, improved, and validated by the working groups. The recommendations covered a wide-ranging aspects of the disease and its treatment: epidemiology, diagnostic modalities, quality criteria and interpretation of chest CT, indication and modalities of lung biopsy, etiologic workup, approach to familial disease entailing indications and modalities of genetic testing, evaluation of possible functional impairments and prognosis, indications for and use of antifibrotic therapy, lung transplantation, symptom management, comorbidities and complications, treatment of chronic respiratory failure, diagnosis and management of acute exacerbations of fibrosis. CONCLUSION: These evidence-based guidelines are aimed at guiding the diagnosis and the management in clinical practice of idiopathic pulmonary fibrosis.

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Fichiers liés : 2023 Cottin et al.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Shreyasi AcharyaDagmar AdamovaAlexander AdlerGianluca Aglieri RinellaMichelangelo AgnelloNeelima AgrawalZubayer AhammedShakeel AhmadSang Un AhnIshaan AhujaAlexander AkindinovMohammad Al-TuranyDmitry AleksandrovBruno AlessandroHaidar Masud AlfandaJose Ruben Alfaro MolinaBushra AliAndrea AliciNegin AlizadehvandchaliAnton AlkinJohan AlmeGiacomo AloccoTorsten AltIgor AltsybeevMustafa AnaamCristian AndreiAnton AndronicVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaL AphecetcheHarald AppelshaeuserCarolina ArataSilvia ArcelliMauro ArestiRoberta ArnaldiIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckMohd Danish AzmiAngela BadalaJoonsuk BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungAlessandro BalbinoAlberto BaldisseriBartosz BalisDebjani BanerjeeZarina BanooRoberto BarberaFrancesco BarileLuca BarioglioMaria BarlouGergely Gabor BarnafoldiLee Stuart BarnbyValerie Ramillien BarretLeonardo Barreto de Oliveira CamposClara BartelsKlaus BarthEsther BartschFilippo BaruffaldiNicole BastidSumit BasuGuillaume BatigneDaniel BattistiniBoris BatyunyaDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenCaitlin BeattiePascal BechtDebadatta BeheraIouri BelikovAilec Bell HechavarriaFrancesca BelliniRene BellwiedSvetlana BelokurovaVladimir BelyaevGyula BencediStefania Maria BeoleAlexandru BercuciYaroslav BerdnikovAnastasia BerdnikovaLuisa BergmannMihaela Gabriela BesoiuLatchezar BetevPartha Pratim BhaduriAnju BhasinMohammad Asif BhatBuddhadeb BhattacharjeeLivio BianchiNicola BianchiJaroslav BielcikJana BielcikovaJacek Bogumil BiernatAlexandre Patrick BigotAnte BilandzicGabor BiroSaikat BiswasNicolas BizéJustin Thomas BlairDmitry BlauMihail Bogdan BlidaruNora BluhmeChristoph BlumeGianluigi BocaFriederike BockTea BodovaAlexey BogdanovStefano BoiJeongsu BokLaszlo BoldizsarAlexander BolozdynyaMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoHannah BossiElena BottaYoussef El Mard BouzianiLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoDmitry BudnikovHenner BueschingStefania BufalinoOphelie BugnonPaul Alois BuhlerEdith Zinhle ButheleziSebastian Adam BysiakMengke CaiHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniFabio de Moraes CanedoMihai CarabasAitor Amatriain CarballoFrancesca CarnesecchiRobin Albert Andre CaronJavier Ernesto Castillo CastellanosFabio CatalanoCesar Ceballos SanchezIrakli ChakaberiaPritam ChakrabortySinjini ChandraSylvain ChapelandMarielle ChartierSubhasis ChattopadhyaySukalyan ChattopadhyayTonatiuh Garcia ChavezTiantian ChengCvetan Valeriev CheshkovBrigitte CheynisVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaPanagiotis ChristakoglouChristian Holm ChristensenPeter ChristiansenTatsuya ChujoMario CiaccoCorrado CicaloFederico CindoloMichael Rudolf CiupekGiulia ClaiFabio Filippo ColamariaJonathan Samuel ColburnDomenico ColellaManuel ColocciMatteo ConcasG. Conesa BalbastreZaida Conesa del ValleGiacomo ContinJesus Guillermo Contreras NunoMaurice Louis CoquetThomas Michael CormierPietro CorteseMauro Rogerio CosentinoFilippo CostaSusanna CostanzaJana CrkovskaPhilippe CrochetReynier Cruz TorresEleazar Cuautle FloresPengyao CuiAndrea DaineseMeike Charlotte DanischAndrea DanuProttay DasProttoy DasSupriya DasArchita Rani DashSadhana DashHector David Regules MedelAnnalisa de CaroGiacinto de CataldoJan de CuvelandAlessandro de FalcoDaniele de GruttolaNora de MarcoChiara de MartinSalvatore de PasqualeSuman DebRoman Jan DebskiKamil Rafal DejaRaffaele del GrandeLuigi Dello StrittoWenjing DengPreeti DhankherDomenico Di BariAntonio Di MauroRaul Arteche DiazThomas DietelYanchun DingRoberto DiviaDhruv Utpalkumar DixitOeystein DjuvslandUliana DmitrievaAlexandru Florin DobrinBenjamin DonigusJan Michal DubinskiAndrea DublaSandeep DudiPascal DupieuxMartin DurkacNatalia DzalaiovaTabea Maria EderRaymond James EhlersViljar Nilsen EikelandFlorian EisenhutDomenico EliaB. 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• Publié dans Phys.Lett.B le 31/10/2025

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Résumé : The study of the azimuthal anisotropy of inclusive muons produced in p–Pb collisions at sNN=8.16 TeV, using the ALICE detector at the LHC is reported. The measurement of the second-order Fourier coefficient of the particle azimuthal distribution, v2, is performed as a function of transverse momentum pT in the 0–20% high-multiplicity interval at both forward (2.03<yCMS<3.53) and backward (−4.46<yCMS<−2.96) rapidities over a wide pT range, 0.5<pT<10 GeV/c, in which a dominant contribution of muons from heavy-flavour hadron decays is expected at pT>2 GeV/c. The v2 coefficient of inclusive muons is extracted using two different techniques, namely two-particle cumulants, used for the first time for heavy-flavour measurements, and forward–central two-particle correlations. Both techniques give compatible results. A positive v2 is measured at both forward and backward rapidities with a significance larger than 4.7σ and 7.6σ, respectively, in the interval 2<pT<6 GeV/c. Comparisons with previous measurements in p–Pb collisions at sNN=5.02 TeV, and with AMPT and CGC-based theoretical calculations are discussed. The findings impose new constraints on the theoretical interpretations of the origin of the collective behaviour in small collision systems.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Shreyasi AcharyaDagmar AdamovaAlexander AdlerGianluca Aglieri RinellaMichelangelo AgnelloNeelima AgrawalZubayer AhammedShakeel AhmadSang Un AhnIshaan AhujaAlexander AkindinovMohammad Al-TuranyDmitry AleksandrovBruno AlessandroHaidar Mas'Ud AlfandaJose Ruben Alfaro MolinaBushra AliAndrea AliciNegin AlizadehvandchaliAnton AlkinJohan AlmeGiacomo AloccoTorsten AltIgor AltsybeevMustafa AnaamCristian AndreiAnton AndronicVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaL AphecetcheHarald AppelshaeuserCarolina ArataSilvia ArcelliMauro ArestiRoberta ArnaldiJhoao Gabriel Martins Campos Almeida ArneiroIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckMohd Danish AzmiAngela BadalaJoonsuk BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungAlessandro BalbinoAlberto BaldisseriBartosz BalisDebjani BanerjeeZarina BanooRoberto BarberaFrancesco BarileLuca BarioglioMaria BarlouGergely Gabor BarnafoldiLee Stuart BarnbyValerie Ramillien BarretLeonardo Barreto de Oliveira CamposClara BartelsKlaus BarthEsther BartschNicole BastidSumit BasuGuillaume BatigneDaniel BattistiniBoris BatyunyaDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenCaitlin BeattiePascal BechtDebadatta BeheraIouri BelikovAilec Bell HechavarriaFrancesca BelliniRene BellwiedSvetlana BelokurovaVladimir BelyaevGyula BencediStefania Maria BeoleAlexandru BercuciYaroslav BerdnikovAnastasia BerdnikovaLuisa BergmannMihaela Gabriela BesoiuLatchezar BetevPartha Pratim BhaduriAnju BhasinMohammad Asif BhatBuddhadeb BhattacharjeeLivio BianchiNicola BianchiJaroslav BielcikJana BielcikovaJacek Bogumil BiernatAlexandre Patrick BigotAnte BilandzicGabor BiroSaikat BiswasNicolas BizéJustin Thomas BlairDmitry BlauMihail Bogdan BlidaruNora BluhmeChristoph BlumeGianluigi BocaFriederike BockTea BodovaAlexey BogdanovStefano BoiJeongsu BokLaszlo BoldizsarMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoHannah BossiElena BottaYoussef El Mard BouzianiLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoMatthew Daniel BucklandDmitry BudnikovHenner BueschingStefania BufalinoPaul Alois BuhlerEdith Zinhle ButheleziAleksandr BylinkinSebastian Adam BysiakMengke CaiHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniFabio de Moraes CanedoMihai CarabasAitor Amatriain CarballoFrancesca CarnesecchiRobin Albert Andre CaronLeopoldo Abranches de CarvalhoJavier Ernesto Castillo CastellanosFabio CatalanoCesar Ceballos SanchezIrakli ChakaberiaPritam ChakrabortySinjini ChandraSylvain ChapelandMarielle ChartierSubhasis ChattopadhyaySukalyan ChattopadhyayTonatiuh Garcia ChavezTiantian ChengCvetan Valeriev CheshkovBrigitte CheynisVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaPanagiotis ChristakoglouChristian Holm ChristensenPeter ChristiansenTatsuya ChujoMario CiaccoCorrado CicaloFederico CindoloMichael Rudolf CiupekGiulia ClaiFabio Filippo ColamariaJonathan Samuel ColburnDomenico ColellaManuel ColocciG. 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TauroGuillermo Tejeda MunozAdriana TelescaLivia TerlizziCristina TerrevoliSanchari ThakurDeepa ThomasAnatoly TikhonovAnthony Robert TimminsMilan TkacikTomas TkacikAlberica ToiaRyoka TokumotoNataliya TopilskayaMarco ToppiFernando Torales AcostaTheraa M.A TorkArianna Grisel Torres RamosAntonio TrifiroAndrea Sofia TrioloSushanta TripathyTulika TripathyStefano TrogoloVictor TrubnikovWladyslaw Henryk TrzaskaTomasz Piotr TrzcinskiAlexandr TumkinRosario TurrisiTrine Spedstad TveterKjetil UllalandBerkin UlukutluAntonio UrasMarta UrioniGianluca UsaiMartin ValaNicolo ValleLennart van DoremalenMarco van LeeuwenCasper Arie van VeenRoelof Jan Gijs van WeeldenPierre Vande VyvreDezso VargaZoltan VargaMaria VasileiouAndrey VasilievOton Vazquez DoceVladimir VecherninErmanno VercellinSergio Vergara LimonLucas Anne VermuntRobert VertesiMarta VerweijLinda VickovicZabulon VilakaziOrlando Villalobos BaillieAnna VillaniGioacchino VinoAlexander VinogradovTiziano VirgiliMaxim Mikael Olavi VirtaVytautas VislaviciusAlexander VodopyanovBenedikt VoelkelMartin Andreas VolklKirill VoloshinSergey VoloshinGiacomo VolpeBarthelemy von HallerIvan VorobyevNikita VozniukJanka VrlakovaChunzheng WangDongfang WangYuanzhe WangAdam Tadeusz WegrzynekFelix Thomas WeiglhoferSandro Christian WenzelJohannes Peter WesselsSierra Lisa WeyhmillerJens WiechulaJon WikneGrzegorz Andrzej WilkJeremy John WilkinsonGuido Alexander WillemsBernd Stefan WindelbandMichael Andreas WinnJosephina Rae WrightWenya WuYitao WuRan XuAnkur YadavArun Kumar YadavSerpil Yalcin KuzuYorito YamaguchiShiming YangSatoshi YanoZhongbao YinIn Kwon YooJin Hee YoonShiming YuanAlperen YuncuValentina ZaccoloChiara ZampolliFederica ZanoneNima ZardoshtiAndrey ZarochentsevPetr ZavadaNikolay ZavyalovMikhail ZhalovBiao ZhangLiuyao ZhangSong ZhangXiaoming ZhangYifei ZhangZhen ZhangMingrui ZhaoVladimir ZherebchevskiiZhi YuDaicui ZhouYou ZhouJianhui ZhuYa ZhuStefan Cristi ZugravelNicola Zurlo
• Organismes : Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique de Clermont Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers
• Publié dans Phys.Rev.D le 11/06/2026

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Résumé : A new, more precise measurement of the $\Lambda$ hyperon lifetime is performed using a large data sample of Pb$-$Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV with ALICE. The $\Lambda$ and $\overline{\Lambda}$ hyperons are reconstructed at midrapidity using their two-body weak decay channel $\Lambda \rightarrow \mathrm{p} + \pi^{-}$ and $\overline{\Lambda} \rightarrow \overline{\mathrm{p}} + \pi^{+}$. The measured value of the $\Lambda$ lifetime is $\tau_{\Lambda} = [261.07 \pm 0.37 \ ( \rm stat.) \pm 0.72 \ (\rm syst.) ]\ \rm ps$. The relative difference between the lifetime of $\Lambda$ and $\overline{\Lambda}$, which represents an important test of CPT invariance in the strangeness sector, is also measured. The obtained value $(\tau_{\Lambda}-\tau_{\overline{\Lambda}})/\tau_{\Lambda} = 0.0013 \pm 0.0028 \ (\mathrm{stat.}) \pm 0.0021 \ (\mathrm{syst.})$ is consistent with zero within the uncertainties. Both measurements of the $\Lambda$ hyperon lifetime and of the relative difference between $\tau_{\Lambda}$ and $\tau_{\overline{\Lambda}}$ are in agreement with the corresponding world averages of the Particle Data Group and about a factor of three more precise.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2023
• Auteurs : Antoine RousselLudovic ChamoinJean-Philippe ArgaudPierre Bousseau
• Organismes : Laboratoire de Mécanique Paris-Saclay

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2023
• Auteurs : Jean-Philippe ColinEmmanuelle BouquetPierre-Yves Le Meur
• Organismes : Savoirs, ENvironnement et Sociétés Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Savoirs, ENvironnement et Sociétés

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Fichiers liés : ID604854.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Dramane KabaMathurin KoffiLingué KouakouEmmanuel N'Gouan KouassiVincent DjohanFabrice CourtinMartial Kassi N'DjetchiBamoro CoulibalyGuy Pacôme AdingraDjakaridja BertéBi Tra Dieudonné TaMinayégninrin KonéBarkissa Mélika TraoréSamuel A. SutherlandRonald E. CrumpChing-I HuangJason MadanPaul R. BessellAntoine BarreauxPhilippe SolanoEmily H. CrowleyKat S. RockVincent Jamonneau
• Organismes : Institut Pierre Richet Université Jean Lorougnon Guédé Programme national d'élimination de la trypanosomiase humaine africaine Institut national de santé publique Institut Pierre Richet Institut de Recherche pour le Développement Université Jean Lorougnon Guédé Institut Pierre Richet Institut Pierre Richet Institut Pierre Richet Institut Pierre Richet Institut Pierre Richet Université Jean Lorougnon Guédé University of Warwick [Coventry] University of Warwick [Coventry] University of Warwick [Coventry] University of Warwick [Coventry] Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Institut de Recherche pour le Développement University of Warwick [Coventry] University of Warwick [Coventry] Institut de Recherche pour le Développement
• Publié dans PLoS Neglected Tropical Diseases le 23/10/2020

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Résumé : Background: Human African trypanosomiasis is a parasitic disease caused by trypanosomes among which Trypanosoma brucei gambiense is responsible for a chronic form (gHAT) in West and Central Africa. Its elimination as a public health problem (EPHP) was targeted for 2020. Côte d'Ivoire was one of the first countries to be validated by WHO in 2020 and this was particularly challenging as the country still reported around a hundred cases a year in the early 2000s. This article describes the strategies implemented including a mathematical model to evaluate the reporting results and infer progress towards sustainable elimination. Methods: The control methods used combined both exhaustive and targeted medical screening strategies including the follow-up of seropositive subjects– considered as potential asymptomatic carriers to diagnose and treat cases– as well as vector control to reduce the risk of transmission in the most at-risk areas. A mechanistic model was used to estimate the number of underlying infections and the probability of elimination of transmission (EoT) was met between 2000–2021 in two endemic and two hypo-endemic health districts. Results: Between 2015 and 2019, nine gHAT cases were detected in the two endemic health districts of Bouaflé and Sinfra in which the number of cases/10,000 inhabitants was far below 1, a necessary condition for validating EPHP. Modelling estimated a slow but steady decline in transmission across the health districts, bolstered in the two endemic health districts by the introduction of vector control. The decrease in underlying transmission in all health districts corresponds to a high probability that EoT has already occurred in Côte d'Ivoire. Conclusion: This success was achieved through a multi-stakeholder and multidisciplinary one health approach where research has played a major role in adapting tools and strategies to this large epidemiological transition to a very low prevalence. This integrated approach will need to continue to reach the verification of EoT in Côte d'Ivoire targeted by 2025.

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Fichiers liés : pntd.0011514.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Marion PinsardArnaud FauconnierFrançois D’halluinPierre Louis BrouxSonia GuerinAnis GasmiJean Philippe HarlicotVincent LavouéJean Marc LevequeAndréa ManuntaKrystel Nyangoh TimohBenoît Peyronnet
• Organismes : UFR Sciences de la santé Simone Veil Institut de recherche en santé, environnement et travail Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
• Publié dans International Urogynecology Journal le 31/10/2020

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Résumé : Introduction and hypothesis: Bladder outlet obstruction (BOO) is a common occurrence after midurethral sling (MUS) insertion and can result in acute or chronic urinary retention or de novo lower urinary tract symptoms (LUTS). However, the management of BOO after MUS is not standardised. The objective of this study was to compare two therapeutic strategies for suspected BOO after MUS. Methods: Patients who had surgical revision for voiding dysfunction with a post-void residual (PVR) ≥100 ml after MUS in five centres between 2005 and 2020 were included in a retrospective study. Patients were divided into two groups: early sling loosening (EL) vs delayed section/excision of the sling (DS). Results: Seventy patients were included: 38 in the EL group and 32 in the DS group. The postoperative complication rate was comparable in both groups (10.5% vs 12.5%; p = 0.99). At 3 months, the rate of withdrawal from self-catheterisation was similar in the two groups (92.1% vs 100%; p = 0.25) as was the PVR (57.5 vs 63.5 ml; p = 0.09). After a median follow-up of 9 months, there were significantly more patients with resolved voiding dysfunction in the EL group (63.2% vs 31.3%; p = 0.01). The rate of persistent/recurrent stress urinary incontinence (SUI) was higher in the DS group (21% vs 43.7%; p = 0.04). In multivariate analysis, the main predictive factor of recurrent SUI was DS (OR 2.87, 95% CI 1.01–8.60, p = 0.048). Conclusions: Early loosening of MUS in the case of postoperative voiding dysfunction offers better efficacy than DS of the sling, with a lower risk of recurrent/persistent SUI.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Jean‐baptiste DucloyerAlexandra PoinasLéa DuchesnePascal CailletCatherine IvanCorinne Lejus-BourdeauNadège LimousinThomas DesmidtPatrick PladysPierre-Jean PisellaAnne BernardHubert LardyPhilippe GohierLudovic MartinFrédéric MouriauxPierre LebranchuRaoul Kanav Khanna
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Centre d’Investigation Clinique de Nantes Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours
• Publié dans Ophthalmology and Therapy le 23/10/2020

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Résumé : IntroductionCataract surgery is the most common surgical procedure performed in France. While the incidence of intraoperative complications affecting visual prognosis is extremely low, given the large number of patients operated on, the absolute number of patients affected by complications is quite high. Complication rates are significantly higher when ophthalmology residents (ORs) perform the surgery. Although lack of experience remains the main risk factor, sleep deprivation may adversely affect ORs' successful surgery rate. The value of the EyeSi and REG; surgical simulator in initial training has been demonstrated to increase cataract surgery safety through the transfer of surgical skills from the simulator to the operating room. However, there is no consensus regarding how much training is needed before the first-time ORs are allowed to operate. There is also no scientific evidence that sleep deprivation is associated with a decrease in surgical performance. Establishing a validated protocol for cataract surgery training using the EyeSi surgical simulator (referred to further as the EyeSi) and identifying risk factors for intraoperative complications related to sleep deprivation will improve cataract surgery safety and lead to the reorganization of our healthcare systems.Methods and Planned OutcomesThis multi-centre educational cohort study will include two distinct axes which will both aim to reduce the risks of cataract surgery. Enrollment will include 16 first-year ORs for Axis 1 and 25 experienced residents for Axis 2, all from the University Hospitals of Nantes, Tours, Angers and Rennes. Axis 1 will focus on investigating the learning curve of first-year ORs using the EyeSi, following the training program recommended by the "College des Ophtalmologistes Universitaires de France" in order to set up a future "licence to operate." Axis 2 will evaluate the impact of sleep deprivation on the surgical performance of experienced ORs using the EyeSi.

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Fichiers liés : s40123-023-00774-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Philippe MerleJean-Frédéric BlancJulien EdelineKarine Le MalicotManon AllaireEric AssenatMeriem GuarssifiMohamed BouattourJean-Marie PéronPierre Laurent-PuigMassimo LevreroCharlotte CostentinBoris GuiuHarry SokolDavid TougeronThomas AparicioJean-Charles NaultJean-Marc Phélip
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre Hospitalier Universitaire de Bordeaux Oncogenesis, Stress, Signaling Lipides - Nutrition - Cancer [Dijon - U1231] CHU Pitié-Salpêtrière [AP-HP] Lipides - Nutrition - Cancer [Dijon - U1231] UFR Sciences Fondamentales et Biomédicales [Sciences] - Université Paris Cité Centre de Recherche en Cancérologie de Lyon Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) CHU Montpellier = Montpellier University Hospital Institut Desbrest d'Epidémiologie et de Santé Publique Centre de Recherche Saint-Antoine FHU Paris Center for Microbiome Medicine Centre hospitalier universitaire de Poitiers = Poitiers University Hospital GHU AP-HP. Université Paris Saclay Centre de Recherche des Cordeliers Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
• Publié dans Digestive and Liver Disease le 01/11/2020

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Résumé : A substantial proportion of patients with hepatocellular carcinoma have to face up, sooner or later, to systemic therapy. The current standards as first line systemic therapies are either atezolizumab (anti-PD-L1) plus bevacizumab (anti-VEGF), or durvalumab (anti-PD-L1) plus tremelimumab (anti-CTLA-4). However, the median overall survival remains below 20 months, and a minority of patients become long-term survivors. Of interest in immune-oncology strategies for hepatocellular carcinoma, the objective response seems to be the most reliable surrogate marker of better overall survival. TRIPLET-HCC (NCT05665348) is a multicentre, randomised, open-label phase II-III trial designed to evaluate efficacy and safety of the triple combination by the addition of ipilimumab (anti-CTLA-4) to atezolizumab/bevacizumab, versus the double atezolizumab/bevacizumab combination. The main inclusion criteria are histologically proven BCLC-B/C HCC without previous systemic therapy. The primary objective of the phase II is the objective response rate in the triple arm, and OS in the triple versus double arms in the phase III. Secondary endpoints common to the phases II and III are the comparisons of progression-free survival, objective response rates, tolerance and quality of life. In addition, genetic and epigenetic studies from tissue and circulating DNA/RNA will be conducted to assess their prognostic or predictive value.

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Fichiers liés : S1590865823001913.pdf

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