Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/08/2022
• Auteurs : Olivia Desgué-ItierLaura SoaresO. AnnevilleDamien BouffardVincent ChanudetPierre-Alain DanisIsabelle DomaisonJean GuillardThéo MazureNajwa SharafFrédéric SoulignacViet Tran KhacBrigitte Vincon-LeiteJean-Philippe Jenny
• Organismes : Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Swiss Federal Institute of Aquatic Science and Technology [Dübendorf] EDF, Hydro Engineering Centre, Environment and Social Department, 73370 Le Bourget-du-Lac, France Pôle Écla - écosystèmes lacustres Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Pôle Écla - écosystèmes lacustres CIPEL, International Commission for the protection of Water Lake Geneva, 1260 Nyon, Switzerland Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Laboratoire Eau Environnement et Systèmes Urbains Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques

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Résumé : Climate change modifies the thermal regime and solubility of oxygen in lakes globally, resulting in the alteration of lake habitats. The use of 1D lake models has become the standard in lake research to evaluate the effects of climate change. However, the required global scale forcing parameters have several limitations, such as the need of downscaling. In this study, we evaluate the possibility to force mechanistic models by following the long-term evolution of shortwave radiation and air temperature while providing realistic seasonal trends for other meteorological parameters. The performance of 1D hydrodynamic lake models was assessed for long-term variations based on 70 years of limnological data collected by the French Observatory of LAkes (OLA). Further, the effects of climate change on the thermal regime and oxygen solubility were analyzed in the four-largest French peri-Alpine lakes. Our results show that 1D models forced by air temperature and short-wave radiation accurately predict variations in lake thermal regime, with RMSE of 1.14 °C. According to model simulations in the epilimnion and hypolimnion respectively, during the last three decades, water temperatures have increased by 0.46 °C/decades (±0.02 °C) and 0.33 °C/decades (±0.06°C). Accordingly, O2 solubility decreased by -0.104 mg/L/decades (±0.005 mg/L) and -0.096 mg/L/decades (±0.011 mg/L) due to thermal change. Based on the ssp370 socio-economic pathway of the IPCC, perialpine lakes will face an increase of 3.80 °C (±0.20 °C) in the future until 2100. These results suggest important degradation in lake thermal and oxygen conditions as well as habitat loss for endemic species.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/08/2022
• Auteurs : Olivia Desgué-ItierLaura Melo Vieira SoaresO. AnnevilleDamien BouffardVincent ChanudetPierre-Alain DanisIsabelle DomaizonJean GuillardThéo MazureNajwa SharafFrédéric SoulignacViet Tran KhacVinçon-Leite BrigitteJean-Philippe Jenny
• Organismes : Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Swiss Federal Institute of Aquatic Science and Technology [Dübendorf] Savoie Technolac Pôle Écla - écosystèmes lacustres Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Pôle Écla - écosystèmes lacustres Commission Internationale pour la Protection des Eaux du Léman Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Laboratoire Eau Environnement et Systèmes Urbains Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques

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Résumé : Climate change modifies the thermal regime and oxygen solubility in lakes globally, resulting in the alteration of lake habitats. The use of 1D lake models has become the standard in lake research to evaluate the effects of climate change. However, the required global scale forcing parameters have several limitations, such as the need of downscaling. Here, we evaluate the possibility to force mechanistic models by following the long-term evolution of shortwave radiation and air temperature while providing realistic seasonal trends for other meteorological parameters. The performance of 1D hydrodynamic lake models was assessed for long-term variations based on 70 years of limnological data collected by the French Observatory of LAkes (OLA). Further the effects of climate change on the thermal regime and oxygen solubility were analyzed in the four-largest French peri-Alpine lakes. Our results show that 1D models forced by air temperature and short-wave radiation accurately predict variations in lake thermal regime, with RMSE of 1.14°C. According to model simulations in the epilimnion and hypolimnion respectively, during the last three decades, water temperatures have increased by 0.46°C/decades (±0.02°C) and 0.33°C/decades (±0.06°C). Accordingly, O2 solubility decreased by -0.104mg/L/decades (±0.005 mg/L) and -0.096mg/L/decades (±0.011 mg/L) due to thermal change. Based on the ssp370 socio-economic pathway of the IPCC, perialpine lakes will face an increase of 3.80°C(±0.20°C) in the future until 2100. These results suggest important degradation in lake thermal and oxygen conditions as well as habitat loss for endemic species.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Marjolaine NgolloKevin PerezNassim HammoudiYuri GorelikMarc DelordClaire AuzolleHugo BottoisDominique Cazals-HatemMadeleine BezaultStéphane NanceyMaria NachuryXavier TretonMathurin FumeryAnthony BuissonNicolas BarnichPhilippe SeksikShai S. Shen-OrrLionel Le BourhisMatthieu AllezHélène CortePierre CattanMircea ChiricaNicolas Munoz-BongrandJean-Marc GornetClotilde BaudryNelson LourencoMarianne MailletMy-Linh Tran-MinhAndrée NisardJoelle BonnetLeila ChedoubaHarry SokolLaurent BeaugerieAnne BourrierIsabelle Nion-LarmurierPhilippe MarteauCecilia LandmanSylvie RajcaElodie QuevrainLoic BrotNajim ChafaiJeremie LefevreEmmanuel TiretMagali SvrcekNadia Hoyau-IdrissiJean François FlejouYoram BouhnikCarmen StefanescuNathalie GuedjYves PanisLeon MaggioriOlivier CorcosGilles BommelaerMarion GoutteEmilie VazeilleMichael RodriguesPierre SauvanetPierre DesreumauxMaria NachuryCoralie SommevilleJean-Louis DupasFranck BrazierDenis ChatelainChristophe AttencourtCharles SabbaghMartine LeconteGilles BoschettiBernard FlouriéYves FrançoisEddy CotteAnne-Laure CharloisPeggy FalgonDriffa MoussataMarion ChauvenetSarah BoyerXavier HebuterneJérome FilippiPaul HofmanMadeleine Bezault
• Organismes : Ecotaxie, microenvironnement et développement lymphocytaire Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Ecotaxie, microenvironnement et développement lymphocytaire Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Ecotaxie, microenvironnement et développement lymphocytaire Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Hopital Saint-Louis [AP-HP] Technion - Israel Institute of Technology [Haifa] Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Ecotaxie, microenvironnement et développement lymphocytaire Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Hopital Saint-Louis [AP-HP] Ecotaxie, microenvironnement et développement lymphocytaire Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Hôpital Beaujon [AP-HP] Remind Study Group Hopital Saint-Louis [AP-HP] Centre Hospitalier Lyon Sud [CHU - HCL] Autophagie infection et immunité - Autophagy Infection Immunity [CIRI] Centre International de Recherche en Infectiologie Hôpital Claude Huriez [Lille] Institute for Translational Research in Inflammation - U 1286 Service de Gastroentérologie [Hôpital Beaujon] CHU Amiens-Picardie Service Hépato-Gastro-Entérologie [CHU Clermont-Ferrand] Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte CHU Saint-Antoine [AP-HP] Technion - Israel Institute of Technology [Haifa] Ecotaxie, microenvironnement et développement lymphocytaire Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Hopital Saint-Louis [AP-HP] Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Ecotaxie, microenvironnement et développement lymphocytaire Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Université Paris Cité Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Centre de Recherche Saint-Antoine FHU Paris Center for Microbiome Medicine CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] FHU Paris Center for Microbiome Medicine CHU Saint-Antoine [AP-HP] Hôpital Lariboisière-Fernand-Widal [APHP] FHU Paris Center for Microbiome Medicine CHU Saint-Antoine [AP-HP] Hôpital Louis Mourier - AP-HP [Colombes] Laboratoire des biomolécules Département de Chimie - ENS-PSL École normale supérieure - Paris Sorbonne Université Institut de Chimie - CNRS Chimie Centre de Recherche Saint-Antoine
• Publié dans Journal of Crohn's and Colitis le 31/10/2020

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Résumé : BACKGROUND AND AIMS: Ileocolonic resection is frequently needed in the course of Crohn's disease [CD] treatment and post-operative recurrence is extremely common. Our main objective was to analyse gene expression in the mucosa of CD patients at the time of surgery and at post-operative endoscopy, in order to identify predictors and mechanisms of early endoscopic recurrence. METHODS: We conducted transcriptome analyses on ileal mucosa samples collected from inflamed sections of the surgical specimens [n = 200], from ileal resection margins [n = 149] and in the neo-terminal ileum 6 months after surgery [n = 122]; these were compared with non-inflammatory bowel disease controls [n = 25]. The primary endpoint was post-operative endoscopic recurrence at 6 months. We applied regression models to identify gene signatures predicting endoscopic recurrence. RESULTS: Chronic inflammation was associated with strong expression of inflammatory genes [IL-6, IL-8, IL-1B] and decreased expression of genes involved in metabolic processes, but with a high inter-individual heterogeneity. Gene signatures associated with early endoscopic recurrence were mainly characterized by upregulation of TNFα, IFNγ, IL23A and IL17A. Pathway analyses showed that upregulation of mitochondrial dysfunction within the inflamed sections and JAK/STAT at the ileal margin were predictive of post-operative recurrence. A combined model integrating these top pathway signatures improved the prediction of endoscopic recurrence [area under the curve of 0.79]. STAT3 phosphorylation at the surgical ileal margin was associated with severe recurrence at 6 months. CONCLUSION: We identified several biological pathways in surgical ileal mucosa specimens associated with an increased risk of disease recurrence. Integration of the JAK/STAT and mitochondrial dysfunction pathways in the clinical model improved the prediction of post-operative recurrence.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Jean-Philippe ColletEric van BelleHolger ThieleSergio BertiThibault LhermusierThibault ManigoldFranz Josef NeumannMartine GilardDavid AttiasFarzin BeyguiAngel CequierFernando AlfonsoPierre AubryFlore BaronnetStephane EderhyMohamad El KastyMathieu KerneïsOlivier BarthelemyThierry LefèvrePascal LeprinceAlban RedheuilPatrick HenryJean-Jacques PortalÉric VicautGilles Montalescot
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Leipzig University / Universität Leipzig Fondazione Toscana Gabriele Monasterio Pôle Cardiovasculaire et Métabolique [CHU Toulouse] Hôpital Guillaume-et-René-Laennec [Saint-Herblain] University Heart Centre Freiburg - Bad Krozingen Centre Hospitalier Régional Universitaire de Brest Centre cardiologique du Nord Hôpital Côte de Nacre [CHU Caen] Bellvitge University Hospital = Bellvitge Hospital Universitari Hospital Universitario de La Princesa AP-HP - Hôpital Bichat - Claude Bernard [Paris] CHU Pitié-Salpêtrière [AP-HP] Groupe Action Groupe Action Groupe Action Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Hôpital Privé Jacques Cartier [Massy] Institut de cardiologie [CHU Pitié-Salpêtrière] Groupe Action Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal Groupe Action Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal Groupe Action Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal CHU Pitié-Salpêtrière [AP-HP] Groupe Action Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Abstract Aims The respective roles of oral anticoagulation or antiplatelet therapy following transcatheter aortic valve implantation (TAVI) remain debated. ATLANTIS is an international, randomized, open-label, superiority trial comparing apixaban to the standard of care. Methods and results After successful TAVI, 1500 patients were randomized (1:1) to receive apixaban 5 mg (2.5 mg if impaired renal function or concomitant antiplatelet therapy) (n = 749) twice daily, or standard of care (n = 751). Randomization was stratified by the need for chronic anticoagulation therapy. Standard-of-care patients received a vitamin K antagonist (VKA) (Stratum 1) or antiplatelet therapy (Stratum 2) if there was an indication for anticoagulation or not, respectively. The primary endpoint was the composite of death, myocardial infarction, stroke or transient ischaemic attack, systemic embolism, intracardiac or bioprosthesis thrombosis, deep vein thrombosis or pulmonary embolism, and life-threatening, disabling, or major bleeding over 1-year follow-up. The primary safety endpoint was major, disabling, or life-threatening bleeding. The primary outcome occurred in 138 (18.4%) and 151 (20.1%) patients receiving apixaban or standard of care, respectively [hazard ratio (HR) 0.92; 95% confidence interval (CI) 0.73–1.16] and there was no evidence of interaction between treatment and stratum (Pinteraction = 0.57). The primary safety endpoint was similar in both groups (HR 1.02; 95% CI 0.72–1.44). In Stratum 1 (n = 451), an exploratory analysis showed no difference for all endpoints between apixaban and VKA. In Stratum 2 (n = 1049), the primary outcome and primary safety endpoint did not differ, but obstructive valve thrombosis was reduced with apixaban vs. antiplatelet therapy (HR 0.19; 95% CI 0.08–0.46), while a signal of higher non-cardiovascular mortality was observed with apixaban. Conclusion After TAVI, apixaban was not superior to the standard of care, irrespective of an indication for oral anticoagulation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Behnood BikdeliCésar CaraballoJavier Trujillo-SantosJean-Philippe GalanaudPierpaolo Di MiccoVladimir RosaGemma Vidal CusidóSebastian SchellongMeritxell MelladoMaría del Valle MoralesOlga Gavín-SebastiánLucia MazzolaiHarlan KrumholzManuel MonrealPaolo PrandoniBenjamin BrennerDominique Farge-BancelRaquel BarbaLaurent BertolettiInna TzoranAbilio ReisMarijan BosevskiHenri BounameauxRadovan MalýPeter VerhammeJoseph CapriniMaría Dolores AdarragaPaloma Agudo de BlasJesús AibarCristina AmadoJuan Ignacio ArcelusAitor BallazCristina BarbagelataManuel BarrónBelén Barrón-AndrésÁngeles Blanco-MolinaFahd Beddar ChaibErnesto BotellaBeatriz Buño-RamiloJoaquín CastroLeyre ChascoJuan CriadoCristina de AncosJavier de MiguelJorge del ToroPablo Demelo-RodríguezAna María Díaz-BraseroMaría del Carmen Díaz-PedrocheJosé Antonio Díaz-PeromingoRaquel Díaz-SimónIrene Milagros DomínguezÁlvaro Dubois-SilvaJosé Carlos EscribanoFrancis EspósitoAna Isabel Farfán-SedanoCarmen Fernández-CapitánJosé Luis Fernández-ReyesÁngeles FidalgoCarme FontIria FranciscoCristina GabaraFrancisco Galeano-ValleMaría Angelina GarcíaFerrán García-BragadoMarta García de HerrerosRocío García de la GarzaCovadonga García-DíazAída Gil-DíazMario Giménez-SuauCovadonga Gómez-CuervoEnric GrauLeticia GuiradoJavier GutiérrezLuis Hernández-BlascoLuis Jara-PalomaresMaría Jesús JarasDavid JiménezRafael JiménezCarmen Jiménez-AlfaroInés JouMaría Dolores JoyaSara Lainez-JustoAntonio LaluezaAna Latorre-DíezJosé Luis LoboLuciano López-JiménezPatricia López-MiguelJuan José López-NúñezRaquel López-ReyesJuan Bosco López-SáezAlicia LorenzoOlga MadridanoAna MaestrePablo Javier MarchenaMar Martín del PozoFrancisco Martín-MartosDiego Martínez-UrbistondoCarmen MellaMaría Isabel MercadoArturo Muñoz-BlancoJosé Antonio NietoManuel Jesús Núñez-FernándezMónica Olid-VelillaSonia OtaloraRemedios OteroDiana Paredes-RuizPedro ParraVirginia ParraJosé María PedrajasMaría Luisa PerisJosé Antonio PorrasJosé PortilloPedro Ruiz-ArtachoNuria Ruiz-GiménezJusto Ruiz-RuizPablo Ruiz-SadaGiorgina SalgueiroRosario Sánchez-MartínezJuan Francisco Sánchez-Muñoz-TorreroTeresa SanchoSilvia SolerBeatriz Suárez-RodríguezJosé María SuriñachCarles TolosaMaría Isabel TorresAndrea Torres-SánchezFernando UresandiBeatriz ValeroReina ValleJosé Felipe VaronaCarmen Vázquez-FriolLaura VelaJerónimo Ramón VelaAurora VillalobosPaula VillaresCarles ZamoraCihan AyStephan NoppIngrid PabingerMatthias EngelenThomas VanasscheHugo Hyung Bok YooJana HirmerovaSandrine AccassatNassim Ait AbdallahAlessandra Bura-RiviereJudith Catella-ChatronFrancis CouturaudBenjamin CrichiPhilippe DebourdeauOlivier EspitiaNicolas FalvoClaire GrangeHélène HelferKarine LacutRaphael Le MaoIsabelle MahéPierre MorangeFarès MoustafaGéraldine PoenouGabrielle Sarlon-BartoliPierre SuchonIsabelle QuereReza NikandishAndrei BraesterGili KenetManuela BasagliaFranca BiloraCristiano BortoluzziBarbara BrandolinMaurizio CiammaichellaChiara CorgnaA. de AngelisEgidio ImbalzanoDaniela MastroiacovoSimona MerlaRaffaele PesaventoFluvio PomeroCarmine SiniscalchiAntonella TufanoAdriana VisonàNgoc Vo HongBeniamino ZalunardoDana KigitovicaElina RusaAndris SkrideSamuel FonsecaFilipa Martins-DuarteJose Meireles
• Organismes : Brigham & Women’s Hospital [Boston] Yale University [New Haven] Cardiovascular Research Foundation [New York, NY, USA] Yale University [New Haven] Universidad Católica San Antonio de Murcia University of Toronto Centre Hospitalier Régional Universitaire [Montpellier] Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia] University Hospital Carl Gustav Carus [Dresden, Germany] Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona IMIM-Hospital del Mar Hospital Clínico Universitario “Lozano Blesa” [Zaragoza, Spain] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Yale School of Medicine [New Haven, Connecticut] Germans Trias i Pujol University Hospital [Badalona, Barcelona, Spain] Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona Università degli Studi di Padova = University of Padua Universidad Católica San Antonio de Murcia Biologie Intégrative du Tissu Osseux Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
• Publié dans JAMA Cardiology le 25/10/2020

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Résumé : Importance: Insufficient data exist about the clinical presentation, short-term, and long-term outcomes of patients with isolated distal deep vein thrombosis (IDDVT), that is, thrombosis in infrapopliteal veins without proximal extension or pulmonary embolism (PE). Objective: To determine the clinical characteristics, short-term, and 1-year outcomes in patients with IDDVT and to compare the outcomes in unadjusted and multivariable adjusted analyses with patients who had proximal DVT. Design, setting, and participants: This was a multicenter, international cohort study in participating sites of the Registro Informatizado Enfermedad Tromboembólica (RIETE) registry conducted from March 1, 2001, through February 28, 2021. Patients included in this study had IDDVT. Patients with proximal DVT were identified for comparison. Patients were excluded if they had a history of asymptomatic DVT, upper-extremity DVT, coexisting PE, or COVID-19 infection. Main outcomes and measures: Primary outcomes were 90-day and 1-year mortality, 1-year major bleeding, and 1-year venous thromboembolism (VTE) deterioration, which was defined as subsequent development of proximal DVT or PE. Results: A total of 33 897 patients were identified with isolated DVT (without concomitant PE); 5938 (17.5%) had IDDVT (mean [SD] age, 61 [17] years; 2975 male patients [50.1%]), and 27 959 (82.5%) had proximal DVT (mean [SD] age, 65 [18] years; 14 315 male patients [51.2%]). Compared with individuals with proximal DVT, those with IDDVT had a lower comorbidity burden but were more likely to have had recent surgery or to have received hormonal therapy. Patients with IDDVT had lower risk of 90-day mortality compared with those with proximal DVT (odds ratio [OR], 0.47; 95% CI, 0.40-0.55). Findings were similar in 1-year unadjusted analyses (hazard ratio [HR], 0.52; 95% CI, 0.46-0.59) and adjusted analyses (HR, 0.72; 95% CI, 0.64-0.82). Patients with IDDVT had a lower 1-year hazard of VTE deterioration (HR, 0.83; 95% CI, 0.69-0.99). In 1-year adjusted analyses of patients without an adverse event within the first 3 months, IDDVT was associated with lower risk of VTE deterioration (adjusted HR, 0.48; 95% CI, 0.24-0.97). By 1-year follow-up, symptoms or signs of postthrombotic syndrome were less common in patients with IDDVT (47.6% vs 60.5%). Conclusions and relevance: Results of this cohort study suggest that patients with IDDVT had a less ominous prognosis compared with patients with proximal DVT. Such differences were likely multifactorial, including the differences in demographics, risk factors, comorbidities, particularly for all-cause mortality, and a potential association of thrombus location with VTE deterioration and postthrombotic syndrome. Randomized clinical trials are needed to assess the optimal long-term management of IDDVT.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : G. ChaithyaPierre WeissGuillaume Daval-FrerotAurelien MassireAlexandre VignaudPhilippe Ciuciu
• Organismes : CEA- Saclay Université Paris-Saclay Signal et Communications Institut de Mathématiques de Toulouse UMR5219 Institut des Technologies Avancées en sciences du Vivant CEA- Saclay Université Paris-Saclay Siemens Healthcare Siemens Healthcare CEA- Saclay CEA- Saclay Université Paris-Saclay
• Publié dans IEEE Transactions on Medical Imaging le 26/10/2020

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Résumé : The Spreading Projection Algorithm for Rapid K-space sampLING, or SPARKLING, is an optimization-driven method that has been recently introduced for accelerated 2D MRI using compressed sensing. It has then been extended to address 3D imaging using either stacks of 2D sampling patterns or a local 3D strategy that optimizes a single sampling trajectory at a time. 2D SPARKLING actually performs variable density sampling (VDS) along a prescribed target density while maximizing sampling efficiency and meeting the gradient-based hardware constraints. However, 3D SPARKLING has remained limited in terms of acceleration factors along the third dimension if one wants to preserve a peaky point spread function (PSF) and thus good image quality. In this paper, in order to achieve higher acceleration factors in 3D imaging while preserving image quality, we propose a new efficient algorithm that performs optimization on full 3D SPARKLING. The proposed implementation based on fast multipole methods (FMM) allows us to design sampling patterns with up to 107 k-space samples, thus opening the door to 3D VDS. We compare multi-CPU and GPU implementations and demonstrate that the latter is optimal for 3D imaging in the high-resolution acquisition regime ( 600μ m isotropic). Finally, we show that this novel optimization for full 3D SPARKLING outperforms stacking strategies or 3D twisted projection imaging through retrospective and prospective studies on NIST phantom and in vivo brain scans at 3 Tesla taking the particular case of T2 *-w imaging. Overall the proposed method allows for 2.5-3.75x shorter scan times compared to GRAPPA-4 parallel imaging acquisition at 3 Tesla without compromising image quality.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Alexandre MansourErwan FlecherMatthieu SchmidtBertrand RozecIsabelle Gouin-ThibaultMaxime EsvanClaire FougerouBruno LevyAlizée PortoJames RossMarylou ParaSabrina ManganielloGuillaume LebretonAndré VincentelliNicolas NesselerMarc PierrotSidney ChocronGuillaume FlicoteauxPhilippe MauriatAlexandre OuattaraHadrien RozeOlivier HuetMarc-Olivier FischerClaire AlessandriRaphel BellaïcheOphélie ConstantQuentin de RouxAndré LyArnaud MeffertJean-Claude MerleNicolas MongardonLucile PicardElena SkripkinaThierry FolliguetAntonio FioreNicolas D’ostrevyMarie-Catherine MorganPierre-Grégoire GuinotMaxime NguyenLucie Gaide-ChevronnayNicolas TerziGwenhaël ColinOlivier FabreArash AstanehJustin IssardElie FadelDominique FabreAntoine GiraultJulien GuihaireIolande IonJean Baptiste MenagerDelphine MitilianOlaf MercierFrançois StephanJacques ThesJerôme JouanThibault DuburcqValentin LoobuyckMouhammed MoussaAgnes MugnierNatacha RousseOlivier DesebbeJean-Luc FellahiRoland HenaineMatteo PozziJean-Christophe RichardZakaria RiadChristophe GuervillySami HraiechLaurent PapazianMatthias CastanierCharles ChanavazCyril CadozSebastien GetteGuillaume LouisErick PortocarreroPhilippe GaudardKais BriniNicolas BischoffAntoine KimmounMathieu MatteiPierre PerezAlexandre BourdiolYannick HourmantPierre-Joachim MahéPierre JaquetBrice Lortat-JacobPierre MordantPatrick NatafJuliette PatrierSophie ProvenchèreMorgan RouéRomain SonnevilleAlexy Tran-DinhPaul-Henri WickyCharles Al ZreibiBernard CholleyYannis GuyonvarchSophie HamadaAnatole HarroisJordi MatielloT KerforneCorentin LacroixNicolas BréchotAlain CombesJuliette ChommelouxJean Michel ConstantinCosimo D’alessandroPierre DemondionAlexandre DemouleMartin DresGuillaume FadelMuriel FartoukhGuillaume HékimianCharles JuvinPascal LeprinceDavid LevyCharles-Edouard LuytMarc Pineton de ChambrunThibaut SchoellPierre FillâtreNicolas MassartRoxane NicolasMaud JonasCharles VidalNicolas AllouSalvatore MuccioDario Di PernaVito-Giovanni RuggieriBruno MourvillierAmedeo AnselmiKarl BounaderYoann LauneyThomas LebouvierAlessandro ParasidoFlorian ReizinePhilippe SeguinEmmanuel BesnierDorothée CarpentierThomas ClavierPierre-Emmanuel FalcozAnne OllandMarion VillardFanny BounesFrançois LabasteVincent MinvilleAntoine GuillonYannick Fedun
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Hôpital Guillaume-et-René-Laennec [Saint-Herblain] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Défaillance Cardiovasculaire Aiguë et Chronique Service de Réanimation Médicale [CHRU Nancy] Hôpital de la Timone [CHU - APHM] University of California [Davis] Laboratoire de Recherche Vasculaire Translationnelle AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Régional Universitaire [CHU Lille] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Intensive Care Medicine le 27/10/2020

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Résumé : Purpose: To describe bleeding and thrombotic events and their risk factors in patients receiving extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) and to evaluate their impact on in-hospital mortality.Methods: The ECMOSARS registry included COVID-19 patients supported by ECMO in France. We analyzed all patients included up to March 31, 2022 without missing data regarding bleeding and thrombotic events. The association of bleeding and thrombotic events with in-hospital mortality and pre-ECMO variables was assessed using multivariable logistic regression models.Results: Among 620 patients supported by ECMO, 29% had only bleeding events, 16% only thrombotic events and 20% both bleeding and thrombosis. Cannulation site (18% of patients), ear nose and throat (12%), pulmonary bleeding (9%) and intracranial hemorrhage (8%) were the most frequent bleeding types. Device-related thrombosis and pulmonary embolism/thrombosis accounted for most of thrombotic events. In-hospital mortality was 55.7%. Bleeding events were associated with in-hospital mortality (adjusted odds ratio (adjOR) = 2.91[1.94-4.4]) but not thrombotic events (adjOR = 1.02[0.68-1.53]). Intracranial hemorrhage was strongly associated with in-hospital mortality (adjOR = 13.5[4.4-41.5]). Ventilation duration before ECMO ≥ 7 days and length of ECMO support were associated with bleeding. Thrombosis-associated factors were fibrinogen ≥ 6 g/L and length of ECMO support.Conclusions: In a nationwide cohort of COVID-19 patients supported by ECMO, bleeding incidence was high and associated with mortality. Intracranial hemorrhage incidence was higher than reported for non-COVID patients and carried the highest risk of death. Thrombotic events were less frequent and not associated with mortality. Length of ECMO support was associated with a higher risk of both bleeding and thrombosis, supporting the development of strategies to minimize ECMO duration.

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Fichiers liés : 2022 Mansour et al., Bleeding.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Candice FabreCaroline ThumerelleMorgane DervauxRola Abou-TaamTiphaine BihoueeJacques BrouardAnnick ClémentChristophe DelacourtCéline DelestrainRalph EpaudSofiane GhdifanAlice HadchouelVéronique HoudouinGéraldine LabouretCaroline PerissonPhilippe ReixMarie-Catherine RenouxFrançoise TroussierLaurence WeissJulie MazenqNadia NathanJean-Christophe Dubus
• Organismes : Hôpital de la Timone [CHU - APHM] Centre Hospitalier Régional Universitaire [CHU Lille] Aix-Marseille Université - École de médecine Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de Pédiatrie Médicale [Caen] CHU Trousseau [APHP] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Intercommunal de Créteil Service de Pneumologie Allergologie [CHU Necker] Immunologie humaine, physiopathologie & immunothérapie CHU Sud Saint Pierre [Ile de la Réunion] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire d'Angers Hôpital Européen Georges Pompidou [APHP] Hôpital de la Timone [CHU - APHM] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique Hôpital de la Timone [CHU - APHM] Microbes Evolution Phylogénie et Infections
• Publié dans European Journal of Pediatrics le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Abdoulaye OuattaraNoemie ResseguierAline CanoPascale de LonlayJean-Baptiste ArnouxAnais BrassierManuel SchiffSamia PichardAlexandre FabreCelia HoebekeNathalie GuffonAlain FouilhouxPierre BrouéGuy TouatiDries DobbelaereKarine MentionFrancois LabartheMarine TardieuLoïc de ParscauFrançois FeilletChrystèle BonnemainsAlice KusterPhilippe LabruneMagalie BarthLena DamajDelphine LamireauJulie BerbisPascal AuquierBrigitte Chabrol
• Organismes : Aix Marseille Université Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans The Journal of Pediatrics le 25/10/2020

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Résumé : Objective The objective of this study was to compare the quality of life (QoL) for parents of children with inborn errors of metabolism (IEMs) requiring a restricted diet with French population norms and investigate parental QoL determinants.

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Fichiers liés : S0022347622008952.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Clément JulienEmré AnakokXavier TretonMaria NachuryStéphane NanceyA. BuissonMathurin FumeryJérôme FilippiLéon MaggioriYves PanisPhilippe ZerbibYves FrançoisAnne DuboisCharles SabbaghAmine RahiliPhilippe SeksikMatthieu AllezJérémie H. LefevrePierre CattanMircea ChiricaNicolas Munoz-BongrandHélène CorteNathan BeaupelJonathan CatryJean-Marc GornetClotilde BaudryNelson LourencoMariane MailletMy-Linh Tran-MinhVictor ChardinyJoelle BonnetLeila ChedoubaAndrée NisardLaurent BeaugerieAnne BourrierIsabelle Nion-LarmurierJulien KirchgesnerCécilia LandmanElodie QuevrainLoic BrotNajim ChafaiYann ParcClothilde DeboveMagali SvreckCamille VincentNathalie GuedjMarianne FerronYoram BouhnikOlivier CorcosCarmen StefanescuSarah KhabilPhilippe MarteauXavier DrayUlrika ChaputGilles BommelaerMarion GoutteJérémie DenizotNicolas BarnichDilek CobanPierre DesreumauxBenjamin ParienteCoralie SommevilleJean-Louis DupasJulien LoreauFranck BrazierDenis ChatelainChristophe AttencourtMartine LeconteGilles BoschettiBernard FlouriéEddy CotteAnne-Laure CharloisPeggy FalgonHelena HadjisavvasDriffa MoussataMarion ChauvenetSarah BoyerXavier HebuterneNadia ArabRaja BarhoumiPaul HofmannSylvain Le CorffAnna BonnetLaura Beyer-BerjotHarry Sokol
• Organismes : Assistance Publique - Hôpitaux de Marseille Laboratoire de Probabilités, Statistique et Modélisation Centre de Recherche Saint-Antoine Service de Gastroentérologie [Hôpital Beaujon] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Lyon Sud [CHU - HCL] Autophagie infection et immunité - Autophagy Infection Immunity [CIRI] Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Service Hépato-Gastro-Entérologie [CHU Clermont-Ferrand] Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Centre Hospitalier Universitaire de Nice Hopital Saint-Louis [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Claude Huriez [Lille] Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL] CHU Clermont-Ferrand Chirurgie digestive [CHU Amiens] Simplification des soins chez les patients complexes - UR UPJV 7518 Centre Hospitalier Universitaire de Nice Centre de Recherche Saint-Antoine FHU Paris Center for Microbiome Medicine Hopital Saint-Louis [AP-HP] CHU Saint-Antoine [AP-HP] FHU Paris Center for Microbiome Medicine Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Beaujon [AP-HP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] CHU Clermont-Ferrand CHU Clermont-Ferrand Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte CHU Clermont-Ferrand Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Amiens-Picardie CHU Amiens-Picardie CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 CHU Amiens-Picardie CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 CHU Amiens-Picardie Centre Hospitalier Lyon Sud [CHU - HCL] Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Nice Institut Polytechnique de Paris Communications, Images et Traitement de l'Information Traitement de l'Information Pour Images et Communications Laboratoire de Probabilités, Statistique et Modélisation FHU Paris Center for Microbiome Medicine Laboratoire de Biomécanique Appliquée MICrobiologie de l'ALImentation au Service de la Santé Centre de Recherche Saint-Antoine FHU Paris Center for Microbiome Medicine MICrobiologie de l'ALImentation au Service de la Santé
• Publié dans Journal of Crohn's and Colitis le 31/10/2020

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Résumé : Background and Aims Surgery is performed in 50–70% of Crohn’s disease [CD] patients, and its main risk is surgical site infection [SSI]. The microbiota has been extensively assessed in CD but not as a potential risk factor for septic morbidity. The objective of this study was to assess the impact of the gut microbiota on SSI in CD.

Methods We used the multicentric REMIND prospective cohort to identify all patients who experienced SSI after ileocolonic resection for CD, defined as any postoperative local septic complication within 90 days after surgery: wound abscess, intra-abdominal collection, anastomotic leakage or enterocutaneous fistula. The mucosa-associated microbiota of the ileal resection specimen was analysed by 16S gene sequencing in 149 patients. The variable selection and prediction were performed with random forests [R package VSURF] on clinical and microbiotal data. The criterion of performance that we considered was the area under the Receiver Operating Characteristic [ROC] curve [AUC].

Results SSI occurred in 24 patients [16.1%], including 15 patients [10.1%] with major morbidity. There were no significant differences between patients with or without SSI regarding alpha and beta diversity. The top selected variables for the prediction of SSI were all microbiota-related. The maximum AUC [0.796] was obtained with a model including 14 genera, but an AUC of 0.78 had already been obtained with a model including only six genera [Hungatella, Epulopiscium, Fusobacterium, Ruminococcaceae_ucg_009, Actinomyces and Ralstonia].

Conclusion The gut microbiota has the potential to predict SSI after ileocolonic resection for CD. It might play a role in this frequent postoperative complication.

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Fichiers liés : Julien2022.pdf

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