Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Chiara RobbaRafael BadenesDenise BattagliniLorenzo BallIole BrunettiJanus JakobsenGisela LiljaHans FribergPedro Wendel-GarciaPaul YoungGlenn EastwoodMichelle ChewJohan UndenMatthew ThomasMichael JoannidisAlistair NicholAndreas LundinJacob HollenbergNaomi HammondManoj SaxenaMartin AnnbornMiroslav SolarFabio TacconeJosef DankiewiczNiklas NielsenPaolo PelosiNiklas NielsenJan BělohlávekClifton CallawayAlain CariouTobias CronbergJosef DankiewiczGlenn EastwoodDavid ErlingeHans FribergJan HovdenesJanus Christian JakobsenMichael JoannidisHans KirkegaardHelena LevinGisela LiljaMatt MorganAlistair NicholPer NordbergMauro OddoPaolo PelosiChristian RylanderManoj SaxenaChristian StormFabio TacconeSusann UllénMatt WisePaul YoungKathy RowanDavid HarrisonPaul MounceyManu Shankar-HariDuncan YoungSusann UllénTheis LangeKarolina PalmérUlla-Britt KarlssonSimon HeisslerFrances BassNaomi HammondJohn MyburghColman TaylorAdele BellinoMarwa Abel-AllBen FinferCarolyn KochYang LiAnne O’connorJulia PilowskyTina SchneiderAnna TippettBridget AdyTessa BroadleyAmanda BrownLiz MelgaardMimi MorganVanessa SinghRebecca SymonsKathrin BeckerNathalie van SanteVendula SaleovaSilvie ZerzanovaHelena LevinSamia Sefir-KribelUte LübeckMario NegriMartina CarraraKathryn FernandoDiane MackleLeanlove NavarraJudith RileyElin WesterheimMarianne FlatebøAmeldina CericZana HaxhijaLovisa TerlingLena BossmarLiz JergleHelén Holm MånssonSamia Abed MaillardAndreja Vujicic ZagarChristina JodlaukHelen HillJennifer ScrivensKate AinscoughCiara FaheyRinaldo BellomoLeah PeckHelen YoungWinston CheungRosalba CrossMichael HayesNitin JainMark KolAsim ShahAtul WaghHelen WongF. Eduardo MartinezGail BrinkerhoffDustin BushAntony StewartAnders AnemanLien LombardoPeter MccannyJames PenkethIan SeppeltRebecca GreshamJulie LowreyKristy MastersChristina WhiteheadJames WalshamMeg HarwardJosephine MackayJason MeyerEmma SaylorEllen VenzKrista WetzigWade StedmanAngela AshelfordSharon MarJulia PilowskyMiyuki TokumitsuElizabeth YaradHergen BuscherClaire ReynoldsAndrew UdyAidan BurrellJasmin CollinsDashiell GantnerVictoria Emma-Leah MartinPhoebe MccrackenVinodh NanjayyaAlistair NicholAlexander Sacha RichardsonMeredith YoungAngaj GhoshSimone SaidMichael JoannidisRonny BeerFrank HartigRaimund HelbokSebastian KleinAndreas PeerFabio TacconeJacques CreteurDominique DurandMatthias DupontSigrid ChristiaensCarola ClaesSebastiaan DeckxBert FerdinandeSanne LenaertsWilifred MullensSarah StroobantsEvi TheunissenDavid VerhaertOndřej ŠmídMarek FlaksaDavid KemlinkJan MalíkMichal OtáhalJan RulíšekMichal ŠíranecZdeněk StachAnna ValeriánováPetra ZavadilovaMiroslav SolařRóber BánszkyJana ČervenáRenata Černá PařízkováLibor ŠimůnekFilip VarhaníkJiří KarásekMatěj StrýčekAnders GrejsSteffen ChristensenPeter Juhl-OlsenIda Katrine ThomsenLisa Gregersen ØstergaardAlain CariouAlbert CaoPierre DuplandAriane GavaudPaul JaubertMathieu JozwiakNathalie MarinGuillaume SavaryNicolas DeyeBruno MégarbanePierre MoraLaetitia SutterlinStephane LegrielHugo BellutAlexis FerreGuillaume LacaveMarine Paul Jean-Baptiste LascarrouEmmanuel CanetCharlotte GarretArnaud Felix MiaihleJean ReignierPhilippe VignonThomas DaixArnaud DesachyBruno EvrardBruno FrancoisAnne-Laure FedouMarine GoudelinChristian StormGabriele KressChristoph LeithnerJens NeeKaspar Josche StreitbergerIole BrunettiLorenzo BallDenise BattagliniGiulia BonattiIacopo FirpoPaolo FrisoniArianna IachiSimona MaianiMaura MandelliChiara RobbaFabio TarantinoAlberto BarbieriElisabetta BertelliniEnrico GiulianiGabriele MelegariErik Roman-PognuzGiorgio BerlotUmberto LucangeloElisabetta MacchiniJan HovdenesVibeke AuneTomas DrægniSimon JacobsenSøren PieschkeÅse RasmussenGro Ringstad AkselsenHalvor LangelandDaniel BergumTherese ErbePål KlepstadHelle NæssRoy Bjørkholt OlsenLena Eriksen SkjelnesMarius HolenJoakim Iver PostRune FanebustLinda Hårteig SørensenKen Åge KårstadCarsten Fredrik WickmanPaul YoungColin BarnesBen BarryNina BeehreDick DinsdaleSam EdneyAnna HuntHarriet JuddCharlotte Latimer-BellCassie LawrenceJames MooreShaanti OlatunjiAlex PsiridesChelsea RobinsonKate TietjensJason WrightDavid KnightBrandon BirkerDavid BowieTara BurkeDavid CloseyRosalind CrombieNeil DavidsonSeton HendersonLouise HitchingsJames MckayJan MehrtensEmmeline MintoStacey MorganAnna MorrisJay Ritzemar-CarterJessica RobertsGeoffrey ShawKatherine TownendKymbalee Vander HeydenChristian RylanderMarita AhlqvistRoman Desta LindgrenIngrid EivingAndreas LundinPatrik MartnerElisabeth MyhrmanBirgitta RydingJoachim DüringMattias BergströmMattias BohmIngrid DidrikssonPetrea FridKatarina HeimburgMarina LarssonOscar LundbergStefan Olsson HauSimon SchmidbauerOla BorgquistAnne AdolfssonAnna BjärnroosErik Blennow-NordströmIrina DraganceaThomas KanderAnna LybeckGustav MattiassonOlof PerssonMalin RundgrenSusann SchreyErik WesthallMartin AnnbornSara AndertunFlorian EbnerNerida GustavssonLisa HasselJesper JohnssonMarie NelderupHeléne PeterssonJörgen PeterssonFrideriki StafilidouJohan UndénFrida AntonssonGit BergmanJörgen GamrothMaria MeirikKatarina RudolfssonHelena SandbergMartin ThorssonKristin SavolainenMaria HansboMalin HellikssonBjörne NödtveidtJohan SannerVictoria SemCamilla Sund LindquistAkil AwadAnna-Sofia BörjessonMalin HedbergMia HenningJacob HollenbergPer PetersenEmelia DahlbergJohan ForshammarVeronica SvenssonMichael WanecekHåkan EskilssonDaniel Rodriguez-SantosÅsa AppelqvistHenrietta JidbrattElisabeth JohanssonLars KiszakiewiczÅsa NilssonSinnika OlssonAnders PaulssonUrszula StempelAndreas ThorenStefan PerssonIda BerglundEric BergströmCathrine TörnqvistIngela ÖstmanSten RubertssonIng-Marie LarssonElin SödermanEwa WallinJoanna WessberghThomas HallidayFilippa EngvallMauro OddoNawfel Ben-HamoudaAdriano BerniniPierre-Nicolas CarronPhilippe EckertEva FavreJohn-Paul MirozPaola MorelliOlivier MullerJan NoviAndrea RossetiMadeleine SchnorfMatthias HaenggiAnja LevisSandra NansozNicole SöllClaudia SchragMensur AlicajicPhilipp BaierJoel DütschlerDominique FlügelEdith FässlerRuth Gamio-VeisMarc GüpfertYvonne HilpertshauserStefan Hägele-LinkGian-Reto KlegerPeter KrähenmannMaria Elisabeth MairNadja SchaiChristoph StrohmaierPeter TanglDominik ZieglgänsbergerMarco MaggioriniGabriele ClausGabi Consani-VogelLukas ImbachSamira KaiserEva-Maria KleinertPedro David Wendel GarciaTiziano CassinaPamela AgazziBruno CapelliGabriele CassoMartino RegazziHervé SchlotterbeckGabriele ViaMichele VillaMatt WiseJenny BrooksEve CocksJade ColeJacqueline CurtinMichelle DaviesRhys DaviesStephen FernandezJulie HighfieldHelen HillMatt MorganLydia PennantSofia RoseEmma ThomasAngharad WilliamsPeter McguiganStephen HaffeyAisling O’neillKathryn WardMatthew ThomasJeremy BewleyAnna ChillingworthJulie CloakeLibby ColeHilary GalvinZoe GarlandLisa GrimmerBethany GumbrillLucy HowieRebekah JohnsonChloe SearlesAgnieszka SkorkoKatie SweetVictoria TaylorDenise WebsterThomas KeebleGill AdamsRajesh AggarwalJo-Anne CartwrightSteven ChurchGerald CleshamJohn DaviesKelly FarrellReto GammaJane HardingRohan JagathesanAlamgir KabirPaul KellyLauren KittridgeMaria MaccaroniGracie MaloneyMarco MionNaveen NainRaghunath NalgirkarGyanesh NamjoshiStacey PepperEmily RedmanNicholas RobinsonJeremy SayerAmanda SolesburyKare TangSali UroviKunal WaghmareNoel WatsonTeresa WebberPeter IsherwoodConor BentleyColin BerginRonald CarreraAmy ClarkLauren CooperLiesl DespyNatalie DooleyKaren EllisEmma FellowsStephanie GoundrySamantha HarkettChristopher McgheeAoife NealHazel SmithCatherine SnelsonElaine SpruceTony WhitehouseKamal YakoubAndrew WaldenShauna BartleyParminder BhuieMatthew FriseNicola JacquesLiza KeatingDavid PogsonZoe DalySteve RoseJonathan Bannard-SmithRachael QuayleNigel CheeNina BarrattKatie BowmanDebbie BranneyElizabeth HoweMaria LettsSally PittsLuke VamplewClifton CallawaySara Difiore SprouseAnkur DoshiJennifer FugateAmy HeadleeEelco Wijdicks
• Organismes : Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Intensive Care Medicine le 27/10/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : Alexandre MansourErwan FlecherMatthieu SchmidtBertrand RozecIsabelle Gouin-ThibaultMaxime EsvanClaire FougerouBruno LevyAlizée PortoJames RossMarylou ParaSabrina ManganielloGuillaume LebretonAndré VincentelliNicolas NesselerMarc PierrotSidney ChocronGuillaume FlicoteauxPhilippe MauriatAlexandre OuattaraHadrien RozeOlivier HuetMarc-Olivier FischerClaire AlessandriRaphel BellaïcheOphélie ConstantQuentin de RouxAndré LyArnaud MeffertJean-Claude MerleNicolas MongardonLucile PicardElena SkripkinaThierry FolliguetAntonio FioreNicolas D’ostrevyMarie-Catherine MorganPierre-Grégoire GuinotMaxime NguyenLucie Gaide-ChevronnayNicolas TerziGwenhaël ColinOlivier FabreArash AstanehJustin IssardElie FadelDominique FabreAntoine GiraultJulien GuihaireIolande IonJean Baptiste MenagerDelphine MitilianOlaf MercierFrançois StephanJacques ThesJerôme JouanThibault DuburcqValentin LoobuyckMouhammed MoussaAgnes MugnierNatacha RousseOlivier DesebbeJean-Luc FellahiRoland HenaineMatteo PozziJean-Christophe RichardZakaria RiadChristophe GuervillySami HraiechLaurent PapazianMatthias CastanierCharles ChanavazCyril CadozSebastien GetteGuillaume LouisErick PortocarreroPhilippe GaudardKais BriniNicolas BischoffAntoine KimmounMathieu MatteiPierre PerezAlexandre BourdiolYannick HourmantPierre-Joachim MahéPierre JaquetBrice Lortat-JacobPierre MordantPatrick NatafJuliette PatrierSophie ProvenchèreMorgan RouéRomain SonnevilleAlexy Tran-DinhPaul-Henri WickyCharles Al ZreibiBernard CholleyYannis GuyonvarchSophie HamadaAnatole HarroisJordi MatielloT KerforneCorentin LacroixNicolas BréchotAlain CombesJuliette ChommelouxJean Michel ConstantinCosimo D’alessandroPierre DemondionAlexandre DemouleMartin DresGuillaume FadelMuriel FartoukhGuillaume HékimianCharles JuvinPascal LeprinceDavid LevyCharles-Edouard LuytMarc Pineton de ChambrunThibaut SchoellPierre FillâtreNicolas MassartRoxane NicolasMaud JonasCharles VidalNicolas AllouSalvatore MuccioDario Di PernaVito-Giovanni RuggieriBruno MourvillierAmedeo AnselmiKarl BounaderYoann LauneyThomas LebouvierAlessandro ParasidoFlorian ReizinePhilippe SeguinEmmanuel BesnierDorothée CarpentierThomas ClavierPierre-Emmanuel FalcozAnne OllandMarion VillardFanny BounesFrançois LabasteVincent MinvilleAntoine GuillonYannick Fedun
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Hôpital Guillaume-et-René-Laennec [Saint-Herblain] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Défaillance Cardiovasculaire Aiguë et Chronique Service de Réanimation Médicale [CHRU Nancy] Hôpital de la Timone [CHU - APHM] University of California [Davis] Laboratoire de Recherche Vasculaire Translationnelle AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Régional Universitaire [CHU Lille] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Intensive Care Medicine le 27/10/2020

---

Résumé : Purpose: To describe bleeding and thrombotic events and their risk factors in patients receiving extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) and to evaluate their impact on in-hospital mortality.Methods: The ECMOSARS registry included COVID-19 patients supported by ECMO in France. We analyzed all patients included up to March 31, 2022 without missing data regarding bleeding and thrombotic events. The association of bleeding and thrombotic events with in-hospital mortality and pre-ECMO variables was assessed using multivariable logistic regression models.Results: Among 620 patients supported by ECMO, 29% had only bleeding events, 16% only thrombotic events and 20% both bleeding and thrombosis. Cannulation site (18% of patients), ear nose and throat (12%), pulmonary bleeding (9%) and intracranial hemorrhage (8%) were the most frequent bleeding types. Device-related thrombosis and pulmonary embolism/thrombosis accounted for most of thrombotic events. In-hospital mortality was 55.7%. Bleeding events were associated with in-hospital mortality (adjusted odds ratio (adjOR) = 2.91[1.94-4.4]) but not thrombotic events (adjOR = 1.02[0.68-1.53]). Intracranial hemorrhage was strongly associated with in-hospital mortality (adjOR = 13.5[4.4-41.5]). Ventilation duration before ECMO ≥ 7 days and length of ECMO support were associated with bleeding. Thrombosis-associated factors were fibrinogen ≥ 6 g/L and length of ECMO support.Conclusions: In a nationwide cohort of COVID-19 patients supported by ECMO, bleeding incidence was high and associated with mortality. Intracranial hemorrhage incidence was higher than reported for non-COVID patients and carried the highest risk of death. Thrombotic events were less frequent and not associated with mortality. Length of ECMO support was associated with a higher risk of both bleeding and thrombosis, supporting the development of strategies to minimize ECMO duration.

---

Fichiers liés : 2022 Mansour et al., Bleeding.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2022
• Auteurs : G. ChaithyaPierre WeissGuillaume Daval-FrerotAurelien MassireAlexandre VignaudPhilippe Ciuciu
• Organismes : CEA- Saclay Université Paris-Saclay Signal et Communications Institut de Mathématiques de Toulouse UMR5219 Institut des Technologies Avancées en sciences du Vivant CEA- Saclay Université Paris-Saclay Siemens Healthcare Siemens Healthcare CEA- Saclay CEA- Saclay Université Paris-Saclay
• Publié dans IEEE Transactions on Medical Imaging le 26/10/2020

---

Résumé : The Spreading Projection Algorithm for Rapid K-space sampLING, or SPARKLING, is an optimization-driven method that has been recently introduced for accelerated 2D MRI using compressed sensing. It has then been extended to address 3D imaging using either stacks of 2D sampling patterns or a local 3D strategy that optimizes a single sampling trajectory at a time. 2D SPARKLING actually performs variable density sampling (VDS) along a prescribed target density while maximizing sampling efficiency and meeting the gradient-based hardware constraints. However, 3D SPARKLING has remained limited in terms of acceleration factors along the third dimension if one wants to preserve a peaky point spread function (PSF) and thus good image quality. In this paper, in order to achieve higher acceleration factors in 3D imaging while preserving image quality, we propose a new efficient algorithm that performs optimization on full 3D SPARKLING. The proposed implementation based on fast multipole methods (FMM) allows us to design sampling patterns with up to 107 k-space samples, thus opening the door to 3D VDS. We compare multi-CPU and GPU implementations and demonstrate that the latter is optimal for 3D imaging in the high-resolution acquisition regime ( 600μ m isotropic). Finally, we show that this novel optimization for full 3D SPARKLING outperforms stacking strategies or 3D twisted projection imaging through retrospective and prospective studies on NIST phantom and in vivo brain scans at 3 Tesla taking the particular case of T2 *-w imaging. Overall the proposed method allows for 2.5-3.75x shorter scan times compared to GRAPPA-4 parallel imaging acquisition at 3 Tesla without compromising image quality.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 27/07/2022
• Auteurs : Agathe DelboveThomas SénagePierre GazengelAdrien TissotPhilippe LacosteLaurent CellerinChristian PerigaudIsabelle Danner-BoucherArnaud CavaillèsThierry LepoivreAntoine MugniotJohanna NicoletDelphine Horeau-LanglardNicolas GroleauYannick FedunBertrand RozecAntoine MagnanJean-Christian RousselFrançois-Xavier Blanc
• Organismes : ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes] methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes] Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Team 4 : Deciphering organ immune regulation in inflammation and transplantation (DORI-t) Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes] Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Guillaume-et-René-Laennec [Saint-Herblain] methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre hospitalier Bretagne Atlantique (Morbihan) ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de pneumologie [Hôpital Foch] Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut du Thorax [CHU Nantes]
• Publié dans Therapeutic Advances in Respiratory Disease le 25/10/2020

---

Résumé : Background: Anastomotic complications are common after lung transplantation (1.4–33% of cases) and still associated with a high morbi-mortality. Methods: The current study is a monocenter retrospective analysis of symptomatic anastomotic complications (SAC) occurring after lung transplantation between 2010 and 2016, using the macroscopic, diameter, and suture (M-D-S) classification from consensus of French experts in bronchoscopy. The objectives were to determine incidence from surgery, risk factors, and impact of survival of SAC. We defined SAC as M-D-S abnormalities (stenosis ⩾ 50% or dehiscence) requiring bronchoscopic or surgical interventions. Results: A total of 121 patients were included. SAC occurred in 26.5% of patients ( n = 32), divided in symptomatic stenosis for 23.7% ( n = 29), and symptomatic dehiscence in 2.5% ( n = 3). In multivariate analysis, donor bacterial lung infection [HR 2.08 (1.04–4.17), p = 0.04] and age above 50 years [HR 3.26 (1.04–10.26), p = 0.04] were associated with SAC occurrence. Cystic fibrosis etiology was associated with better survival on Kaplan–Meier curve ( p < 0.001). SAC [HR 2.15 (1.07–4.32), p = 0.03] was independently associated with worst survival. The 29 symptomatic patients because of stenosis required endoscopic procedure, of whom 16 patients needed bronchial stent placement. Four patients underwent surgery: three patients because of dehiscence and one because of severe bilateral stenosis (re-transplantation). Discussion: SAC occurred in 26.5% of patients. Donor lung infection was the only alterable identified factors. The increase rate of SAC in older patients above 50 years of age encourages in regular endoscopic monitoring.

---

Fichiers liés : 2022_delbove_THERAPEUTIC ADVANCES inRespiratory Disease.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 24/07/2022
• Auteurs : Jean-Philip BrugalGuy AndréJean-Baptiste FourvelPhilippe FosseMarina IgrejaPierre MagniezLéo PascalA. Uzunidis
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Institut Català de Paleoecologia Humana i Evolució Social

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2022
• Auteurs : Shengli TaoJérôme ChavePierre-Louis FrisonThuy Le ToanPhilippe CiaisJingyun FangWigneron J.-P.Maurizio SantoroHui YangXiaojun LiNicolas LabrièreSassan Saatchi
• Organismes : Evolution et Diversité Biologique Peking University [Beijing] Evolution et Diversité Biologique Laboratoire en Sciences et Technologies de l'Information Géographique Centre d'études spatiales de la biosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Peking University [Beijing] Interactions Sol Plante Atmosphère Gamma Remote Sensing Research and Consulting AG Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Evolution et Diversité Biologique Jet Propulsion Laboratory
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

---

Résumé : Intact tropical rainforests have been exposed to severe droughts in recent decades, which may threaten their integrity, their ability to sequester carbon, and their capacity to provide shelter for biodiversity. However, their response to droughts remains uncertain due to limited high-quality, long-term observations covering extensive areas. Here, we examined how the upper canopy of intact tropical rainforests has responded to drought events globally and during the past 3 decades. By developing a long pantropical time series (1992 to 2018) of monthly radar satellite observations, we show that repeated droughts caused a sustained decline in radar signal in 93%, 84%, and 88% of intact tropical rainforests in the Americas, Africa, and Asia, respectively. Sudden decreases in radar signal were detected around the 1997–1998, 2005, 2010, and 2015 droughts in tropical Americas; 1999–2000, 2004–2005, 2010–2011, and 2015 droughts in tropical Africa; and 1997–1998, 2006, and 2015 droughts in tropical Asia. Rainforests showed similar low resistance (the ability to maintain predrought condition when drought occurs) to severe droughts across continents, but American rainforests consistently showed the lowest resilience (the ability to return to predrought condition after the drought event). Moreover, while the resistance of intact tropical rainforests to drought is decreasing, albeit weakly in tropical Africa and Asia, forest resilience has not increased significantly. Our results therefore suggest the capacity of intact rainforests to withstand future droughts is limited. This has negative implications for climate change mitigation through forest-based climate solutions and the associated pledges made by countries under the Paris Agreement.

---

Fichiers liés : pnas.2116626119.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2022
• Auteurs : Friedrich WalzelAlice RequierKevin BoschiJean FaragoPhilippe FuchsFabrice ThalmannWiebke Drenckhan-AndreattaPierre MullerThierry Charitat
• Organismes : Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron
• Publié dans Physical Review E le 21/10/2020

---

Résumé : Minimal surface problems arise naturally in many soft matter systems whose free energies are dominated by surface or interface energies. Of particular interest are the shapes, stability and mechanical stresses of minimal surfaces spanning specific geometric boundaries. The "catenoid" is the best-known example where an analytical solution is known which describes the form and stability of a minimal surface held between two parallel, concentric circular frames. Here we extend this problem to non-axisymmetric, parallel frame shapes of different orientations, by developing a perturbation approach around the known catenoid solution. We show that the predictions of the perturbation theory are in good agreement with experiments on soap films and finite element simulations (Surface Evolver). Combining theory, experiment and simulation, we analyse in depth how the shapes, stability and mechanical properties of the minimal surfaces depend on the type and orientation of elliptical and three-leaf clover shaped frames. In the limit of perfectly aligned non-axisymmetric frames, our predictions show excellent agreement with a recent theory established by Alimov et al (M. M. Alimov, A. V. Bazilevsky and K. G. Kornev, Physics of Fluids, 2021, 33, 052104). Moreover, we put in evidence the intriguing capacity of minimal surfaces between non-axisymmetric frames to transmit a mechanical torque despite being completely liquid. These forces could be interesting to exploit for mechanical self-assembly of soft matter systems or as highly sensitive force captors.

---

Fichiers liés : 2203.16140.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 17/07/2022
• Auteurs : Niranjan ThatteDave MelotteBenoit NeichelDavid Le MignantIan BrysonArthur ViganFraser ClarkeVanessa Ferraro-WoodThierry FuscoOscar GonzalezHermine SchnetlerMatthias TeczaSandi WilsonAlonso Álvarez UrueñaHeribert VilasecaSantiago Arribas MocoroaGonzalo José Carracedo CarballaleAlejandro CrespoAlberto Estrada PiquerasMiriam García GarcíaCecilia Martínez MartínMiguel Pereira SantaellaMichele PernaJavier Piqueras LópezNicolas F. BouchéDidier BoudonEric DaguiséKaren DisseauJérémy FenschAdrien GirardotMatthieu GuibertAurélien JarnoAlexandre JeanneauJens-Kristian KrogagerFlorence LaurentMagali LoupiasJean-Emmanuel MigniauLaure PiquerasAlban RemillieuxJohan P RichardArlette Pécontal-RoussetLisa BardouDavid BarrSylvain CetreRishi DeshmukhSofia DimoudiMarc DubbledamAndrew DunnDimitra GadottiJoss GuyDavid KingDavid LittleAnna McleodSimon MorrisTim MorrisKieran O'BrienEmily RonsonRussell SmithLazar StaykovMark SwinbankMatthew TownsonMatteo AccardoDomingo Alvarez MendezElizabeth GeorgeJoshua HopgoodDerek IvesLeander MehrganEric MuellerJavier Reyes-MorenoRalf ConzelmannPablo Gutierrez CheethamÁngel Alonso-SánchezGiuseppina BattagliaMiguel Angel Cagigas GarciaHaresh ChulaniGraciela Delgado GarcíaPatricia Fernández-IzquierdoAna Belén Fragoso LópezBegoña García-LorenzoAlberto Hernández GonzálezElvio Hernández SuárezJose Miguel Herreros LinaresEnrique JovenRoberto López LópezAlejandro Antonio Lujan GonzalezYolanda MartínEvencio MediavillaSaúl Menéndez MendozaLuz Maria Montoya MartínezJosé Peñate CastroÁlvaro PérezJosé Luis RasillaRafael Rebolo-LópezLuis Fernando Rodríguez-RamosAfrodisio Vega MorenoTeodora Viera-CurbeloNatacha Zanon DamettoAlexis CarlottiJean-Jacques CorreiaStéphane CurabaAlain DelboulbéSylvain GuieuAdrien HoursZoltan HubertLaurent JocouYves MagnardThibaut MoulinFabrice PancherPatrick RabouEric StadlerMaxime VéroveT. ContiniMarie LarrieuOlivier BoebionYan Fantéï-CaujolleDaniel LecronSylvain RousseauPhilippe AmramOlivier Beltramo-MartinWilliam BonAnne BonnefoiWilliam CeriaZalpha ChallitaYannick CharlesElodie ChoquetCarlos CorreiaAnne CostilleKjetil DohlenFranck DucretKacem El HadiJean-Luc GachJean-Luc GimenezOlivier GroussinMarc JaquetPierre JouveFabrice MadecFelipe Pedreros BustosEdgard RenaultPatrice SanchezPascal VolaAnnie ZavagnoRomain FétickC B LimCyril PetitJ.-F. SauvageNicolas VédrenneFehim Taha BagciMartin CaldwellEllis ElliottPeter HiscockEmma JohnsonMurali NalagatlaAristea SeitisMark WellsMartin BlackCharlotte BondSaskia BrierleyKenneth CampbellNeil CampbellJames CarruthersWilliam CochraneChris EvansJoel HarmanWilliam HumphreysThomas LouthChris MillerDavid MontgomeryMeenu MuraliJohn MurrayNorman O'MalleyRuben Sanchez-JanssenNoah SchwartzPatrick SmithJonathan StrachanStephen ToddStuart WattMartyn WellsAsim YaqoobEric BellOleg GnedinKayhan GultekinMario MateoMichael MeyerMunadi AhmadJayne BirkbyMichael BoothMichele CappellariEdgar Castillo DominguezJorge Chao OrtizDavid GoodingKearn GrisdaleAndrea Hidalgo ValadezLaurence HoganJames KariukiIan LewisAdam LoweZeynep OzerLaurence RoutledgeDimitra RigopoulouAlec York
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille DOTA, ONERA, Université Paris Saclay [Palaiseau] Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Institut de recherche en astrophysique et planétologie Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Institut universitaire de France DOTA, ONERA, Université Paris Saclay [Châtillon] DOTA, ONERA [Salon-de-Provence] DOTA, ONERA, Université Paris Saclay [Châtillon]

---

Résumé : HARMONI is the first light, adaptive optics assisted, integral field spectrograph for the European Southern Observatory’s Extremely Large Telescope (ELT). A work-horse instrument, it provides the ELT’s diffraction limited spectroscopic capability across the near-infrared wavelength range. HARMONI will exploit the ELT’s unique combination of exquisite spatial resolution and enormous collecting area, enabling transformational science. The design of the instrument is being finalized, and the plans for assembly, integration and testing are being detailed. We present an overview of the instrument’s capabilities from a user perspective, and provide a summary of the instrument’s design. We also include recent changes to the project, both technical and programmatic, that have resulted from red-flag actions. Finally, we outline some of the simulated HARMONI observations currently being analyzed.

---

Fichiers liés : 1218420.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 16/07/2022
• Auteurs : Pierre DrossartPanek EmilieVirginie BatistaJean-Philippe BeaulieuJean-Pierre Maillard
• Organismes : Institut d'Astrophysique de Paris

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2022
• Auteurs : Seda SerenJean-Patrick JolyPierre VoisinVéronique BouchaudGérard AudranSylvain R A MarquePhilippe Mellet
• Organismes : Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques
• Publié dans Journal of Medicinal Chemistry le 25/10/2020

---

Résumé : Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil elastase activity in cancer is associated with poor prognosis and metastasis settlement. More generally, tumors harbor various and persistent protease activities unseen in healthy tissues. In an attempt to be more specific, we designed prodrugs that are activatable by neutrophil elastase. Upon activation, these alkoxyamine-based drugs release cytotoxic alkyl radicals that act randomly to prevent drug resistance. As a result, U87 glioblastoma cells displayed high level caspase 3/7 activation during the first hour of exposure in the presence of human neutrophil elastase and the prodrug in vitro. The apoptosis process and cell death occurred between 24 and 48 h after exposure with a half lethal concentration of 150 μM. These prodrugs are versatile and easy to synthetize and can be adapted to many enzymes.

---

Source