Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 07/09/2022
• Auteurs : Jean‐philippe MorrettonAnthony SimonAurélie HerbetteJorge BarbazanCarlos Pérez-GonzálezCamille CossonBassirou MboupAurélien LatoucheTatiana PopovaYann KiefferAnne-Sophie MacéPierre GestraudGuillaume BataillonVéronique BecetteDidier MeseureAndré NicolasOdette MarianiAnne Vincent-SalomonMarc‐henri SternFatima Mechta-GrigoriouSergio Roman RomanDanijela Matic VignjevicRoman RouzierXavier Sastre-GarauOumou GoundiamRenata Basto
• Organismes : Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] UFR Sciences de la santé Simone Veil Institut Curie [Paris] Centre Hospitalier Intercommunal de Créteil Institut Curie [Paris] Institut Curie [Paris]
• Publié dans EMBO Molecular Medicine le 23/10/2020

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Résumé : Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations are frequently present. To address this question, we have analyzed a large cohort of primary human epithelial ovarian cancers (EOCs) from 100 patients. We found that rigorous quantitation of centrosome number in tumor samples was extremely challenging due to tumor heterogeneity and extensive tissue disorganization. Interestingly, even if centrosome clusters could be identified, the incidence of centrosome amplification was not comparable to what has been described in cultured cancer cells. Surprisingly, centrosome loss events where a few or many nuclei were not associated with centrosomes were clearly noticed and overall more frequent than centrosome amplification. Our findings highlight the difficulty of characterizing centrosome numbers in human tumors, while revealing a novel paradigm of centrosome number defects in EOCs.

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Fichiers liés : EMBO Mol Med - 2022 - Morretton - A catalog of numerical centrosome defects in epithelial ovarian cancers.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/09/2022
• Auteurs : Wieneke DijkMathilde Di FilippoSander KooijmanRobin Van EenigeAntoine RimbertAmandine CaillaudAurélie ThedrezLucie ArnaudAmanda PronkDamien GarçonThibaud SotinPierre LindenbaumEnrique Ozcariz GarciaJean-Paul Pais De BarrosLaurence DuvillardKarim Si-TayebNuria AmigoJy. Le QuestelPatrick C.N. RensenCedric Le MayPhilippe MoulinBertrand Cariou
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Leiden University Medical Center [Leiden] Leiden University Medical Center [Leiden] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Leiden University Medical Center [Leiden] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Biosfer Teslab [Reus, Spain] Lipides - Nutrition - Cancer [Dijon - U1231] Lipides - Nutrition - Cancer [Dijon - U1231] CHU Dijon ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Biosfer Teslab [Reus, Spain] Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation Leiden University Medical Center [Leiden] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Cardiovasculaire, métabolisme, diabétologie et nutrition Hôpital Louis Pradel [CHU - HCL] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
• Publié dans Circulation le 29/10/2020

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Résumé : BACKGROUND: Atherosclerotic cardiovascular disease is the main cause of mortality worldwide and is strongly influenced by circulating low-density lipoprotein (LDL) cholesterol levels. Only a few genes causally related to plasma LDL cholesterol levels have been identified so far, and only 1 gene, ANGPTL3, has been causally related to combined hypocholesterolemia. Here, our aim was to elucidate the genetic origin of an unexplained combined hypocholesterolemia inherited in 4 generations of a French family. METHODS: Using next-generation sequencing, we identified a novel dominant rare variant in the LIPC gene, encoding for hepatic lipase, which cosegregates with the phenotype. We characterized the impact of this LIPC-E97G variant on circulating lipid and lipoprotein levels in family members using nuclear magnetic resonance-based lipoprotein profiling and lipidomics. To uncover the mechanisms underlying the combined hypocholesterolemia, we used protein homology modeling, measured triglyceride lipase and phospholipase activities in cell culture, and studied the phenotype of APOE*3.Leiden.CETP mice after LIPC-E97G overexpression. RESULTS: Family members carrying the LIPC-E97G variant had very low circulating levels of LDL cholesterol and high-density lipoprotein cholesterol, LDL particle numbers, and phospholipids. The lysophospholipids/phospholipids ratio was increased in plasma of LIPC-E97G carriers, suggestive of an increased lipolytic activity on phospholipids. In vitro and in vivo studies confirmed that the LIPC-E97G variant specifically increases the phospholipase activity of hepatic lipase through modification of an evolutionarily conserved motif that determines substrate access to the hepatic lipase catalytic site. Mice overexpressing human LIPC-E97G recapitulated the combined hypocholesterolemic phenotype of the family and demonstrated that the increased phospholipase activity promotes catabolism of triglyceride-rich lipoproteins by different extrahepatic tissues but not the liver. CONCLUSIONS: We identified and characterized a novel rare variant in the LIPC gene in a family who presents with dominant familial combined hypocholesterolemia. This gain-of-function variant makes LIPC the second identified gene, after ANGPTL3, causally involved in familial combined hypocholesterolemia. Our mechanistic data highlight the critical role of hepatic lipase phospholipase activity in LDL cholesterol homeostasis and suggest a new LDL clearance mechanism.

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Fichiers liés : CIRCULATIONAHA.121.057978.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/09/2022
• Auteurs : Guillaume CourtierEmmanuel PecheurRonan AdamPierre LapraySébastien ChangeyJean-Philippe Lauffenburger
• Organismes : Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 Institut franco-allemand de recherches de Saint-Louis = French-German Research Institute of Saint-Louis = Deutsch-Französisches Forschungsinstitut Saint-Louis Institut franco-allemand de recherches de Saint-Louis = French-German Research Institute of Saint-Louis = Deutsch-Französisches Forschungsinstitut Saint-Louis Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 Information Systems Laboratory [Stanford] Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499

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Résumé : Avec les progrès des véhicules autonomes, la navigation basée sur des caméras est de plus en plus utilisée. Une nouvelle méthode de navigation utilisant des caméras polarisées est présentée. Pour cela, un système d'acquisition et un algorithme de traitement d'images ont été développés afin d'estimer le cap d'un véhicule grâce à la polarisation de la lumière du ciel. La précision de la méthode est quantifiée à l'aide d'un banc tournant à partir duquel le cap estimé par les caméras est comparé au feedback donné par la platine rotative.

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Fichiers liés : gretsi2022.pdf

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• Type de publi. :
• Date de publi. : 05/09/2022
• Auteurs : Christine DupuyHélène AgoguéBenjamin AmannFréderic AzémarNicolas BecuLauriane BergeonX. BertinPierrick BocherEmilie BoutIsabelle BrenonAlexandre CarpentierSerge CeauxEric ChaumillonCatherine ChoquetBéatrice ColinJonathan DebordeEmmanuel DubillotEmery ClaireSylvie FerrariCédric GaucherelPhilippe GeaironStéphane GilbertMarc JeanninJ. JourdeDimitri KalenitchenkoNicolas LachausséeThomas Lacoue-LabartheIsabelle LannelucLaura LavaudSébastien LavaudChristel LefrançoisVincent Le FouestInès Le FurNathalie LongPierre-Yves MahieuxJérémy MayenCaroline MaraisÉdouard MetzgerRaphaël MoncelonVincent OuisseJean-Christophe PéreauJulien PétillonOlivier PhilippinePhilippe PineauCécilia Pignon-MussaudPierre PolsenaereRené SabotPhilippe RefaitElodie RéveillacFrançois-Xavier RobinHélène RouquetteSophie SabléPierre-Guy SauriauMichèle TackxPhilippe TurcryMarie VagnerJulia VincentN Volto
• Organismes : LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Laboratoire Ecologie Fonctionnelle et Environnement LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Communauté d'Agglomération de La Rochelle LIttoral ENvironnement et Sociétés Biologie des Organismes et Ecosystèmes Aquatiques Université de Rennes Communauté d'Agglomération de La Rochelle LIttoral ENvironnement et Sociétés Mathématiques, Image et Applications LIttoral ENvironnement et Sociétés Laboratoire Environnement Ressources des Pertuis Charentais Institut Français de Recherche pour l'Exploitation de la Mer LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Bordeaux Sciences Economiques Botanique et Modélisation de l'Architecture des Plantes et des Végétations Laboratoire Environnement Ressources des Pertuis Charentais Institut Français de Recherche pour l'Exploitation de la Mer Communauté d'Agglomération de La Rochelle Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Bordeaux Sciences Economiques LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Laboratoire Environnement Ressources des Pertuis Charentais LIttoral ENvironnement et Sociétés Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire Environnement Ressources des Pertuis Charentais LIttoral ENvironnement et Sociétés Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire de Planétologie et Géosciences [UMR_C 6112] LIttoral ENvironnement et Sociétés MARine Biodiversity Exploitation and Conservation - MARBEC Bordeaux Sciences Economiques Ecosystèmes, biodiversité, évolution [Rennes] Institute for Coastal and Marine Research and Department of Zoology [Port Elizabeth] Union des marais de la Charente-Maritime LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Laboratoire Environnement Ressources des Pertuis Charentais Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 LIttoral ENvironnement et Sociétés Union des marais de la Charente-Maritime DDAF LA ROCHELLE LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés Laboratoire Ecologie Fonctionnelle et Environnement Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Environnement Marin (LEMAR) LIttoral ENvironnement et Sociétés LIttoral ENvironnement et Sociétés

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Résumé : Rising greenhouse gas emissions are causing increasing worldwide impacts and changes on climate patterns, sea level, food production, human lives and livelihoods. Maintaining or improving the ability of coastal aquatic ecosystems and oceans to remove CO2 from the atmosphere is a crucial aspect for climate mitigation. The vegetated coastal ecosystems are able to catch and to sequestrate carbon, the so-called Blue Carbon. These ecosystems are key exchange zones that mediate the biogeochemical cycles across the continent, the ocean and the atmosphere. Given the importance of these ecosystems in biogeochemical cycles and their sensitivity to natural and anthropogenic pressures, the carbon cycle within and between compartments (e.g. pelagos, benthos…) and across the interfaces (e.g. atmosphere, ocean…) need to be addressed. On a regional scale, in the extended urban area of La Rochelle located on the French Atlantic coast (La Rochelle metropolitan area), lack in situ measurements within the wetlands and littoral zone make very uncertain their role as a sink or a source of CO2 to the atmosphere. We will first present a vast research project “La Rochelle Territoire Zéro Carbone” project (https://www.agglo-larochelle.fr/projet-de-territoire/territoire-zero-carbone), that target the ambition of carbon neutrality in La Rochelle metropolitan area by 2040 through a holistic approach (from measuring CO2 to raising people's awareness and assessing the impact of exogenous natural factors). Second, we will present some first results on the Blue Carbon dynamics within the freshwater and salt marshes, and seagrasses.

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Fichiers liés : Dupuy-etal_2022_PosterECSA-LRTZC_VF.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/09/2022
• Auteurs : Lucy KunduraSandrine GimenezRenaud CezarSonia AndréMehwish YounasYea-Lih LinPierre PortalèsClaire LozanoCharlotte BoulléJacques ReynesThierry VincentClément MettlingPhilippe PaseroLaurent MullerJean-Yves LefrantClaire Penetrat-RogerPierre-Géraud ClaretSandra DuvnjakPaul LoubetAlbert SottoTu Anh TranJérôme EstaquierPierre Corbeau
• Organismes : Institut de génétique humaine Institut de génétique humaine Centre Hospitalier Universitaire de Nîmes Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire Centre Hospitalier Régional Universitaire [Montpellier] Institut de génétique humaine Institut de génétique humaine Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut de génétique humaine Institut de génétique humaine Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Laboratoire de Bioingénierie et NanoSciences Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Département Maladies Infectieuses et Tropicales [CHRU Montpellier] Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nîmes Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Centre Hospitalier Universitaire de Nîmes Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire CHU de Québec–Université Laval Institut de génétique humaine
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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Résumé : Background: Lymphopenia is predictive of survival in patients with coronavirus disease 2019 (COVID-19). Objective: The aim of this study was to understand the cause of the lymphocyte count drop in severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Monocytic production of reactive oxygen species (ROSs) and T-cell apoptosis were measured by flow cytometry, DNA damage in PBMCs was measured by immunofluorescence, and angiotensin II (AngII) was measured by ELISA in patients infected with SARS-CoV-2 at admission to an intensive care unit (ICU) (n 5 29) or not admitted to an ICU (n 5 29) and in ageand sex-matched healthy controls. Results: We showed that the monocytes of certain patients with COVID-19 spontaneously released ROSs able to induce DNA damage and apoptosis in neighboring cells. Of note, high ROS production was predictive of death in ICU patients. Accordingly, in most patients, we observed the presence of DNA damage in up to 50% of their PBMCs and T-cell apoptosis. Moreover, the intensity of this DNA damage was linked to lymphopenia. SARS-CoV-2 is known to induce the internalization of its receptor, angiotensin-converting enzyme 2, which is a protease capable of catabolizing AngII. Accordingly, in certain patients with COVID-19 we observed high plasma levels of AngII. When looking for the stimulus responsible for their monocytic ROS production, we revealed that AngII triggers ROS production by monocytes via angiotensin receptor I. ROSs released by AngII-activated monocytes induced DNA damage and apoptosis in neighboring lymphocytes. Conclusion: We conclude that T-cell apoptosis provoked via DNA damage due to the release of monocytic ROSs could play a major role in COVID-19 pathogenesis.

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Fichiers liés : re-MS clear copy.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/09/2022
• Auteurs : Eva-Maria AhrerLili AldersonNatalie BatalhaNatasha BatalhaJacob BeanThomas BeattyTaylor BellBjörn BennekeZachory Berta-ThompsonAarynn CarterIan CrossfieldNéstor EspinozaAdina FeinsteinJonathan FortneyNeale GibsonJayesh GoyalEliza M.-R. KemptonJames KirkLaura KreidbergMercedes López-MoralesMichael LineJoshua LothringerSarah MoranSagnick MukherjeeKazumasa OhnoVivien ParmentierCaroline PiauletZafar RustamkulovEverett SchlawinDavid SingKevin StevensonHannah WakefordNatalie AllenStephan BirkmannJonathan BrandeNicolas CrouzetPatricio CubillosMario DamianoJean-Michel DésertPeter GaoJoseph HarringtonRenyu HuSarah KendrewHeather KnutsonPierre-Olivier LagageJérémy LeconteMonika LendlRyan MacdonaldE. MayYamila MiguelKaran MolaverdikhaniJulianne I. MosesCatriona Anne MurrayMolly NehringNikolay NikolovD. Petit Dit de la RocheMichael RadicaPierre-Alexis RoyKeivan StassunJake TaylorWilliam WaalkesPatcharapol WachiraphanLuis WelbanksPeter WheatleyKeshav AggarwalMunazza AlamAgnibha BanerjeeJoanna BarstowJasmina BlecicS. CasewellQuentin ChangeatK. ChubbKnicole ColónLouis-Philippe CoulombeTansu DaylanMiguel de Val-BorroLeen DecinLeonardo dos SantosLaura FlaggKevin FranceGuangwei FuA. García MuñozJohn GizisAna GliddenDavid GrantKevin HengThomas HenningYu-Cian HongJulie InglisNicolas IroTiffany KatariaThaddeus KomacekJessica KrickElspeth LeeNikole LewisJorge Lillo-BoxJacob Lustig-YaegerLuigi ManciniAvi MandellMegan MansfieldMark MarleyThomas Mikal-EvansGiuseppe MorelloMatthew NixonKevin Ortiz CeballosAnjali PietteDiana PowellBenjamin RackhamLakeisha Ramos-RosadoEmily RauscherSeth RedfieldLaura RogersMichael T. RomanGael RoudierNicholas ScarsdaleEvgenya ShkolnikJohn SouthworthJessica SpakeMaria SteinrueckXianyu TanJohanna TeskePascal TremblinShang-Min TsaiGregory TuckerJake TurnerJeff ValentiOlivia VenotIngo WaldmannNicole WallackXi ZhangSebastian Zieba
• Organismes : H. H. Wills Physics Laboratory [Bristol] Department of Physics [McGill University] Département de Physique [Montréal] Department of Astrophysical and Planetary Sciences [Boulder] University of California MIT Kavli Institute for Astrophysics and Space Research Max-Planck-Institut für Astronomie University of California Astrophysics Research Centre [Belfast] Carl Sagan Institute University of Exeter Grinnell College Imperial College London Max-Planck-Institut für Astronomie Harvard-Smithsonian Center for Astrophysics Laboratoire Interuniversitaire des Systèmes Atmosphériques
• Publié dans Nature le 29/10/2020

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Résumé : Abstract Carbon dioxide (CO 2 ) is a key chemical species that is found in a wide range of planetary atmospheres. In the context of exoplanets, CO 2 is an indicator of the metal enrichment (that is, elements heavier than helium, also called ‘metallicity’) 1–3 , and thus the formation processes of the primary atmospheres of hot gas giants 4–6 . It is also one of the most promising species to detect in the secondary atmospheres of terrestrial exoplanets 7–9 . Previous photometric measurements of transiting planets with the Spitzer Space Telescope have given hints of the presence of CO 2 , but have not yielded definitive detections owing to the lack of unambiguous spectroscopic identification 10–12 . Here we present the detection of CO 2 in the atmosphere of the gas giant exoplanet WASP-39b from transmission spectroscopy observations obtained with JWST as part of the Early Release Science programme 13,14 . The data used in this study span 3.0–5.5 micrometres in wavelength and show a prominent CO 2 absorption feature at 4.3 micrometres (26-sigma significance). The overall spectrum is well matched by one-dimensional, ten-times solar metallicity models that assume radiative–convective–thermochemical equilibrium and have moderate cloud opacity. These models predict that the atmosphere should have water, carbon monoxide and hydrogen sulfide in addition to CO 2 , but little methane. Furthermore, we also tentatively detect a small absorption feature near 4.0 micrometres that is not reproduced by these models.

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Fichiers liés : s41586-022-05269-w.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Tim DarsautElsa MagroMichel BojanowskiChiraz ChaalalaLorena NicoEmma BacchusRuby KlinkDaniela IancuAlain WeillDaniel RoyJean-Francois SabatierChristophe CognardAnne-Christine JanuelIsabelle Pelissou-GuyotatOmer EkerPierre-Hugues RocheThomas GraillonHervé BrunelFrancois ProustRémy BeaujeuxSorin AldeaMichel PiotinPhilippe CornuEimad ShotarThomas GaberelCharlotte BarbierMarine Le CorreVincent CostalatVincent JeckoXavier BarreauXavier MorandiJean-Yves GauvritStéphane DerreyChrysanthi PapagiannakiThanh NguyenMohamad AbdalkaderRabih TawkThien HuynhGeraldine ViardGuylaine GevryJean-Christophe GentricJean RaymondJean RaymondJeremy RempelCian O’kellyMichael ChowJ. Max FindlayRobert FahedHoward LesiukBrian DrakeMarlene Dos SantosRomuald SeizeurMichel NonentSerge TimsitOlivier PradierJulien OgnardMourad Cheddad El-AouniHubert DesalRomain BoursierFrançois ThillaysVincent RoualdesRaphael BlancLionel CalviereJean Yves GauvritIsabelle LecouillardElodie NouhaudHélène RaoultFrançois EugeneAnthony Le BrasJean-Christophe FerreChristophe PayaThomas RonziereDenis TrystramOlivier NaggaraChristine Rodriguez-RegentBasile KerlerouxEvelyne EmeryEmmanuel TouzeIsabelle Pellisou-GuyotatJacques GuyotatMonsef BerhoumaRoberto RivaChloé DumotAlessandra BiondiLaurent ThinesGuillaume CharbonnierNassim BougaciSerge BracardRené AnxionnatValérie Bernier-ChastagnerThierry CivitBenjamin GoryGuillaume PenchetEdouard GimbertGaulthier MarnatAymeri HuchetDenis HerbreteauGrégoire BoulouisStéphane VelutRichard BibiHéloïse IferganKévin JanotHadrien PeyriereJean-Marc KayaAdamou ToutaLucas TroudeSébastien BoissonneauAnne-Laure BochFrédéric ClarençonNader SourourAurélien NouetStéphanie LenckKévin PrematAlain BonafeCyril DargazanliGregory GascouPierre-Henri LefevreCarlos RiquelmeHélène CebulaIrène OllivierRaoul PopGiorgio SpatolaLaurent SpelleVanessa ChalumeauSophie GallasLéon IkkaCristian MihaleaAugustin OzanneJildaz CaroffEmmanuel ChabertCharbel MounayerAymeric RouchaudFrançois CaireFrédéric RicolfiCatherine CaoKlaus-Luc MourierPierre ThouantWalid FarahAndrew CarlsonLuciana Alves Oliveira SilvaNayara de Lima FroioGisele Sampaio SilvaFrancisco Mont’alverneJose Luri MartinsGeorge Nunes MendesRodrigo Rivera Miranda
• Organismes : Provincial Laboratory for Public Health [Alberta, Canada] Université de Bretagne Occidentale - UFR Médecine et Sciences de la Santé - Brest Laboratoire de Traitement de l'Information Medicale Université du Québec à Montréal = University of Québec in Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Provincial Laboratory for Public Health [Alberta, Canada] Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada] Centre Hospitalier de l'Université de Montréal EPI-PHARE Laboratoire de Génie Informatique, de Production et de Maintenance Service Neurochirurgie [CHU Toulouse] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Hospices Civils de Lyon Service de neuroradiologie [Lyon] Aix Marseille Université Hôpital Nord [CHU - APHM] Marseille medical genetics - Centre de génétique médicale de Marseille Institut Marseille Maladies Rares Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Assistance Publique - Hôpitaux de Marseille Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Service de radiologie [Strasbourg] Département de Neuroradiologie [Strasbourg] Hôpital Foch [Suresnes] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Physiopathologie et imagerie des troubles neurologiques Service de Neurochirurgie [CHU Caen] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Gui de Chauliac [CHU Montpellier] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Neuroimagerie: méthodes et applications Service de Neurochirurgie [CHU Rouen] Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau Institute for Research and Innovation in Biomedicine Centre d'Investigation Clinique [CHU Rouen] UNIROUEN - UFR Santé CHU Rouen National Institute of Veterinary Research [Hanoï] Boston University School of Medicine Hôpital de la Cavale Blanche - CHRU Brest Hôpital de la Cavale Blanche - CHRU Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] The Ottawa Hospital
• Publié dans Journal of Neurosurgery le 26/10/2020

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Résumé : OBJECTIVE The Treatment of Brain Arteriovenous Malformations Study (TOBAS) is a pragmatic study that includes 2 randomized trials and registries of treated or conservatively managed patients. The authors report the results of the surgical registry. METHODS TOBAS patients are managed according to an algorithm that combines clinical judgment and randomized allocation. For patients considered for curative treatment, clinicians selected from surgery, endovascular therapy, or radiation therapy as the primary curative method, and whether observation was a reasonable alternative. When surgery was selected and observation was deemed unreasonable, the patient was not included in the randomized controlled trial but placed in the surgical registry. The primary outcome of the trial was mRS score > 2 at 10 years (at last follow-up for the current report). Secondary outcomes include angiographic results, perioperative serious adverse events, and permanent treatment-related complications leading to mRS score > 2. RESULTS From June 2014 to May 2021, 1010 patients were recruited at 30 TOBAS centers. Surgery was selected for 229/512 patients (44%) considered for curative treatment; 77 (34%) were included in the surgery versus observation randomized trial and 152 (66%) were placed in the surgical registry. Surgical registry patients had 124/152 (82%) ruptured and 28/152 (18%) unruptured arteriovenous malformations (AVMs), with the majority categorized as low-grade Spetzler-Martin grade I–II AVM (118/152 [78%]). Thirteen patients were excluded, leaving 139 patients for analysis. Embolization was performed prior to surgery in 78/139 (56%) patients. Surgical angiographic cure was obtained in 123/139 all-grade (89%, 95% CI 82%–93%) and 105/110 low-grade (95%, 95% CI 90%–98%) AVM patients. At the mean follow-up of 18.1 months, 16 patients (12%, 95% CI 7%–18%) had reached the primary safety outcome of mRS score > 2, including 11/16 who had a baseline mRS score ≥ 3 due to previous AVM rupture. Serious adverse events occurred in 29 patients (21%, 95% CI 15%–28%). Permanent treatment-related complications leading to mRS score > 2 occurred in 6/139 patients (4%, 95% CI 2%–9%), 5 (83%) of whom had complications due to preoperative embolization. CONCLUSIONS The surgical treatment of brain AVMs in the TOBAS registry was curative in 88% of patients. The participation of more patients, surgeons, and centers in randomized trials is needed to definitively establish the role of surgery in the treatment of unruptured brain AVMs. Clinical trial registration no.: NCT02098252 ( ClinicalTrials.gov )

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Dominique BazinEddy FoySolenn RéguerStéphan RouzièreBarbara FayardHester ColbocJean-Philippe HaymannMichel DaudonCristian Mocuta
• Organismes : Institut de Chimie Physique Laboratoire de Physique des Solides IRAMAT - Laboratoire Métallurgies et Cultures Laboratoire Archéomatériaux et Prévision de l'Altération Synchrotron SOLEIL Laboratoire de Physique des Solides - MATRIX Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE CHU Rothschild [AP-HP] CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal Synchrotron SOLEIL
• Publié dans Comptes Rendus. Chimie le 30/10/2020

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Résumé : This contribution tries to indicate to the clinician what kind of information can be investigated through X-ray fluorescence, what kind of information can be extracted from this spectroscopy and finally how it competes with other tools described in previous publications such as Fourier Transform Infrared or Raman spectroscopy, X-ray Absorption Near Edge Structure spectroscopy and X-ray diffraction. To attain this goal, several examples based on X-ray fluorescence experiments performed on biological samples namely concretions, medical devices, biological fluids as well as tissues are presented.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : William DanjouPaul ChabertThomas PerpointPierre PradatPatrick MiailhesAndré BoibieuxAgathe BeckerCarine FuchsmannFrédéric LaurentStéphane TringaliSandrine RouxClaire Triffault-FillitFlorent ValourTristan FerrySandrine RouxMarie SimonAnne ConradCécile PouderouxPierre ChauvelotPaul ChabertJohanna LippmanEvelyne BraunSébastien LustigElvire ServienCécile BataillerStanislas GunstAxel SchmidtElliot Sappey-MarinierQuentin OdeMichel-Henry FessyAnthony VisteJean-Luc BessePhilippe ChaudierLucie LouboutinAdrien van HaeckeMarcelle MercierVincent BelgaidAram GazarianArnaud WalchAntoine BertaniFrédéric RongierasSébastien MartresFranck TrouilletCédric BarreyAli MojallalSophie BrossetCamille HanriatMathilde LhermHélène PersonPhilippe CéruseCarine FuchsmannArnaud GleizalFrédéric AubrunMikhail DziadzkoCaroline MacabéoDana PatrascuFrederic LaurentLaetitia BeraudTiphaine Roussel-GaillardCéline DupieuxCamille KolendaJérôme JosseFabien CraigheroL. BousselJean-Baptiste PialatIsabelle MorelecMichel TodMarie-Claude GagnieuSylvain GoutelleCatherine PironEugénie Mabrut
• Organismes : Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Groupement Hospitalier Nord, Hospices Civils de Lyon Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Institut des Agents Infectieux [Lyon] Service de Chirurgie Maxillofaciale de l'Hôpital de la Croix-Rousse Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Background Necrotizing external otitis (NEO) is a severe infection of the skull base that occurs generally in the elderly and/or in diabetic recipients. There are few data in the literature about the therapeutic management of this complex bone infection. Objectives To analyse relapses after NEO treatment completion, and to describe the clinical features of NEO. Methods We performed a retrospective cohort study in the Lyon regional reference centre for the management of complex bone and joint infections. Consecutive cases of NEO from 1 January 2006 to 31 December 2018 were included. The primary outcome was the relapse of NEO. Variables were analysed using Cox regression survival analysis with adjusted hazard ratio (aHR) and Kaplan–Meier curve. Results Sixty-six patients were included. Median age was 75 (IQR 69–81) years and 46 (70%) patients were diabetic. Eleven patients (17%) had temporomandibular arthritis, 10 (15%) cranial nerve paralysis, 2 (3%) cerebral thrombophlebitis, and 2 (3%) contiguous abscess. Microbiological documentation was obtained in 56 patients and revealed Pseudomonas aeruginosa in 44/56 patients (79%). Nine (14%) cases had no microbiological documentation. Antibiotic therapy was dual for 63 (95%) patients. During a median follow-up of 27 (IQR 12–40) months, 16 out of 63 (25%) patients experienced a relapse. Fungal infection was significantly associated with relapse [aHR 4.1 (95% CI 1.1–15); P = 0.03]. Conclusions NEO is a severe bone infection, mainly (but not exclusively) caused by P. aeruginosa, which occurs in elderly and diabetic recipients. Fungal infections at baseline significantly impact the outcome.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Lucas HenryDominique BazinClotilde PolicarJean-Philippe HaymannMichel DaudonVincent FrochotMuriel Mathonnet
• Organismes : Laboratoire des biomolécules Université Paris Sciences et Lettres École normale supérieure - Paris Sorbonne Université Université Paris-Saclay Laboratoire de Physique des Solides Institut de Chimie Physique Laboratoire des biomolécules Université Paris Sciences et Lettres École normale supérieure - Paris Sorbonne Université CHU Tenon [AP-HP] Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation CHU Tenon [AP-HP] Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation CHU Tenon [AP-HP] Hôpital Dupuytren [CHU Limoges]
• Publié dans Comptes Rendus. Chimie le 30/10/2020

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Résumé : In this contribution, we have characterized for the first time (to the best of our knowledge), microcalcifications present in fine needle aspiration (FNA) smears of thyroid nodules. Abnormal deposits were analysed through Fourier Transform Infrared Spectroscopy (FTIR) and Field Emission Scanning Electron Microscopy (FE-SEM) in order to obtain their chemical composition as well as their morphology at the micrometer scale. Thirty-one samples coming from 13 patients were investigated comprising five cases of papillary carcinoma, two of Graves’ disease, and six of adenomatous goitre. The smears were also stained for analysis of the cellular characteristics of these lesions for classifying according to the Bethesda classification. Two mineral species, amorphous and nanocrystallised apatite calcium phosphate, have been identified with very different morphologies. Moreover, FE-SEM observations at the micrometer scale underline the presence of different kinds of abnormal deposits.

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Fichiers liés : crchim20220080_1Juin2022-NOMARKEDITOR.pdf

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