Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Dominique BazinEddy FoySolenn RéguerStéphan RouzièreBarbara FayardHester ColbocJean-Philippe HaymannMichel DaudonCristian Mocuta
• Organismes : Institut de Chimie Physique Laboratoire de Physique des Solides IRAMAT - Laboratoire Métallurgies et Cultures Laboratoire Archéomatériaux et Prévision de l'Altération Synchrotron SOLEIL Laboratoire de Physique des Solides - MATRIX Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE CHU Rothschild [AP-HP] CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal Synchrotron SOLEIL
• Publié dans Comptes Rendus. Chimie le 30/10/2020

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Résumé : This contribution tries to indicate to the clinician what kind of information can be investigated through X-ray fluorescence, what kind of information can be extracted from this spectroscopy and finally how it competes with other tools described in previous publications such as Fourier Transform Infrared or Raman spectroscopy, X-ray Absorption Near Edge Structure spectroscopy and X-ray diffraction. To attain this goal, several examples based on X-ray fluorescence experiments performed on biological samples namely concretions, medical devices, biological fluids as well as tissues are presented.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 01/09/2022
• Auteurs : Elise LaruelleKatia BelcramAlain TrubuilJean-Christophe PalauquiPhilippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] Institut Jean-Pierre Bourgin - Sciences du végétal Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : Abstract Noise plays a major role in cellular processes and in the development of tissues and organs. Several studies have examined the origin, the integration or the accommodation of noise in gene expression, cell growth and elaboration of organ shape. By contrast, much less is known about variability in cell division plane positioning, its origin and links with cell geometry, and its impact on tissue organization. Taking advantage of the first-stereotyped-then-variable division patterns in the embryo of the model plant Arabidopsis thaliana, we combined 3D imaging and quantitative cell shape and cell lineage analysis together with mathematical and computer modeling to perform a large scale, systematic analysis of variability in division plane orientation. Our results reveal that, paradoxically, variability in cell division patterns of Arabidopsis embryos is accompanied by a progressive reduction of cell shape heterogeneity. The paradox is solved by showing that variability operates within a reduced repertoire of possible division plane orientations that is related to cell geometry. We show that in several domains of the embryo, a recently proposed geometrical division rule recapitulates observed variable patterns, thus suggesting that variable patterns emerge from deterministic principles operating in a variable geometrical context. Our work highlights the importance of emerging patterns in the plant embryo under iterated division principles, but also reveal domains where deviations between rule predictions and experimental observations point to additional regulatory mechanisms.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Sébastien GaujouxGuillaume MartinEric MiralliéNicolas RegenetMaëlle Le BrasFrançois PattouBruno CarnailleCatherine Cardot-BautersLionel GroussinMatthieu FaronPhilippe ChansonHaythem NajahAntoine TabarinAlain SauvanetPhilippe RuszniewskiJean Christophe LifanteThomas WalterNicolas CarrèrePhilippe CaronSophie DeguelteBrigitte DelemerChristine BinquetAnne Sophie JannotPierre Goudet
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Cochin [AP-HP] Institut Gustave Roussy Département de chirurgie viscérale [Gustave Roussy] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier Universitaire de Bordeaux Université de Bordeaux Hôpital Beaujon [AP-HP] Hôpital Beaujon [AP-HP] Centre Hospitalier Lyon Sud [CHU - HCL] Université Claude Bernard Lyon 1 Université Toulouse III Paul Sabatier - Faculté de médecine Purpan Centre Hospitalier Universitaire de Toulouse Hôpital Robert Debré Hôpital Robert Debré Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Centre de Recherche des Cordeliers Health data- and model- driven Knowledge Acquisition Service d'Hépato-Gastro-Entérologie (CHU de Dijon)
• Publié dans British Journal of Surgery le 29/10/2020

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Résumé : Abstract Background The overall natural history, risk of death and surgical burden of patients with multiple endocrine neoplasia type 1 (MEN1) is not well known. Methods Patients with MEN1 from a nationwide cohort were included. The survival of patients with MEN1 was compared with that of the general population using simulated controls. The cumulative probabilities of MEN1-specific operations and postoperative mortality were assessed, and surgical sequences were analysed using sunburst charts and Venn diagrams. Results A total of 1386 patients with MEN1 were included. Life expectancy was significantly reduced in patients with MEN1 compared with simulated controls from the general population, with a lifetime difference of 15 years. Mutations affecting the JunD interaction domain had a significant negative impact on survival. Survival for patients with MEN1 compared with the general population improved over time. The probability of experiencing at least one specific MEN1 operation was above 95 per cent after 75 years, and most patients had surgery at least twice during their lifetime. Time to a 50 per cent risk of MEN1 surgery was 30.5 years for patients born after 1960, compared with 47.9 years for those born before 1960. Sex and mutations affecting the JunD interacting domain had no impact on time to first surgery. There was considerable heterogeneity in surgical sequences, with no specific clinical pathway. Conclusion Life expectancy was significantly lower among patients with MEN1 compared with the general population, and further decreased in patients with mutations affecting the JunD interacting domain. Almost all patients underwent at least one MEN1-specific operation during their lifetime, but there was no standardized sequence of surgery.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Dominique BazinElise BouderliqueMichel DaudonVincent FrochotJean-Philippe HaymannEmmanuel LetavernierFrederik TielensRaphaël Weil
• Organismes : Institut de Chimie Physique Laboratoire de Physique des Solides CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal Vrije Universiteit Brussel [Bruxelles] Institut de Chimie Physique
• Publié dans Comptes Rendus. Chimie le 30/10/2020

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Résumé : Since its first use several decades ago, scanning electron microscopy has been used in numerous investigations dedicated to biological systems. This contribution focuses on observations on pathological calcifications in order to review several major applications of primary importance to the clinician. Among these, we highlight such observations as medical diagnostic tools in pathologies arising from primary hyperoxaluria and urinary infections.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Tim DarsautElsa MagroMichel BojanowskiChiraz ChaalalaLorena NicoEmma BacchusRuby KlinkDaniela IancuAlain WeillDaniel RoyJean-Francois SabatierChristophe CognardAnne-Christine JanuelIsabelle Pelissou-GuyotatOmer EkerPierre-Hugues RocheThomas GraillonHervé BrunelFrancois ProustRémy BeaujeuxSorin AldeaMichel PiotinPhilippe CornuEimad ShotarThomas GaberelCharlotte BarbierMarine Le CorreVincent CostalatVincent JeckoXavier BarreauXavier MorandiJean-Yves GauvritStéphane DerreyChrysanthi PapagiannakiThanh NguyenMohamad AbdalkaderRabih TawkThien HuynhGeraldine ViardGuylaine GevryJean-Christophe GentricJean RaymondJean RaymondJeremy RempelCian O’kellyMichael ChowJ. Max FindlayRobert FahedHoward LesiukBrian DrakeMarlene Dos SantosRomuald SeizeurMichel NonentSerge TimsitOlivier PradierJulien OgnardMourad Cheddad El-AouniHubert DesalRomain BoursierFrançois ThillaysVincent RoualdesRaphael BlancLionel CalviereJean Yves GauvritIsabelle LecouillardElodie NouhaudHélène RaoultFrançois EugeneAnthony Le BrasJean-Christophe FerreChristophe PayaThomas RonziereDenis TrystramOlivier NaggaraChristine Rodriguez-RegentBasile KerlerouxEvelyne EmeryEmmanuel TouzeIsabelle Pellisou-GuyotatJacques GuyotatMonsef BerhoumaRoberto RivaChloé DumotAlessandra BiondiLaurent ThinesGuillaume CharbonnierNassim BougaciSerge BracardRené AnxionnatValérie Bernier-ChastagnerThierry CivitBenjamin GoryGuillaume PenchetEdouard GimbertGaulthier MarnatAymeri HuchetDenis HerbreteauGrégoire BoulouisStéphane VelutRichard BibiHéloïse IferganKévin JanotHadrien PeyriereJean-Marc KayaAdamou ToutaLucas TroudeSébastien BoissonneauAnne-Laure BochFrédéric ClarençonNader SourourAurélien NouetStéphanie LenckKévin PrematAlain BonafeCyril DargazanliGregory GascouPierre-Henri LefevreCarlos RiquelmeHélène CebulaIrène OllivierRaoul PopGiorgio SpatolaLaurent SpelleVanessa ChalumeauSophie GallasLéon IkkaCristian MihaleaAugustin OzanneJildaz CaroffEmmanuel ChabertCharbel MounayerAymeric RouchaudFrançois CaireFrédéric RicolfiCatherine CaoKlaus-Luc MourierPierre ThouantWalid FarahAndrew CarlsonLuciana Alves Oliveira SilvaNayara de Lima FroioGisele Sampaio SilvaFrancisco Mont’alverneJose Luri MartinsGeorge Nunes MendesRodrigo Rivera Miranda
• Organismes : Provincial Laboratory for Public Health [Alberta, Canada] Université de Bretagne Occidentale - UFR Médecine et Sciences de la Santé - Brest Laboratoire de Traitement de l'Information Medicale Université du Québec à Montréal = University of Québec in Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Provincial Laboratory for Public Health [Alberta, Canada] Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada] Centre Hospitalier de l'Université de Montréal EPI-PHARE Laboratoire de Génie Informatique, de Production et de Maintenance Service Neurochirurgie [CHU Toulouse] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Hospices Civils de Lyon Service de neuroradiologie [Lyon] Aix Marseille Université Hôpital Nord [CHU - APHM] Marseille medical genetics - Centre de génétique médicale de Marseille Institut Marseille Maladies Rares Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Assistance Publique - Hôpitaux de Marseille Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Service de radiologie [Strasbourg] Département de Neuroradiologie [Strasbourg] Hôpital Foch [Suresnes] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Physiopathologie et imagerie des troubles neurologiques Service de Neurochirurgie [CHU Caen] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Gui de Chauliac [CHU Montpellier] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Neuroimagerie: méthodes et applications Service de Neurochirurgie [CHU Rouen] Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau Institute for Research and Innovation in Biomedicine Centre d'Investigation Clinique [CHU Rouen] UNIROUEN - UFR Santé CHU Rouen National Institute of Veterinary Research [Hanoï] Boston University School of Medicine Hôpital de la Cavale Blanche - CHRU Brest Hôpital de la Cavale Blanche - CHRU Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] The Ottawa Hospital
• Publié dans Journal of Neurosurgery le 26/10/2020

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Résumé : OBJECTIVE The Treatment of Brain Arteriovenous Malformations Study (TOBAS) is a pragmatic study that includes 2 randomized trials and registries of treated or conservatively managed patients. The authors report the results of the surgical registry. METHODS TOBAS patients are managed according to an algorithm that combines clinical judgment and randomized allocation. For patients considered for curative treatment, clinicians selected from surgery, endovascular therapy, or radiation therapy as the primary curative method, and whether observation was a reasonable alternative. When surgery was selected and observation was deemed unreasonable, the patient was not included in the randomized controlled trial but placed in the surgical registry. The primary outcome of the trial was mRS score > 2 at 10 years (at last follow-up for the current report). Secondary outcomes include angiographic results, perioperative serious adverse events, and permanent treatment-related complications leading to mRS score > 2. RESULTS From June 2014 to May 2021, 1010 patients were recruited at 30 TOBAS centers. Surgery was selected for 229/512 patients (44%) considered for curative treatment; 77 (34%) were included in the surgery versus observation randomized trial and 152 (66%) were placed in the surgical registry. Surgical registry patients had 124/152 (82%) ruptured and 28/152 (18%) unruptured arteriovenous malformations (AVMs), with the majority categorized as low-grade Spetzler-Martin grade I–II AVM (118/152 [78%]). Thirteen patients were excluded, leaving 139 patients for analysis. Embolization was performed prior to surgery in 78/139 (56%) patients. Surgical angiographic cure was obtained in 123/139 all-grade (89%, 95% CI 82%–93%) and 105/110 low-grade (95%, 95% CI 90%–98%) AVM patients. At the mean follow-up of 18.1 months, 16 patients (12%, 95% CI 7%–18%) had reached the primary safety outcome of mRS score > 2, including 11/16 who had a baseline mRS score ≥ 3 due to previous AVM rupture. Serious adverse events occurred in 29 patients (21%, 95% CI 15%–28%). Permanent treatment-related complications leading to mRS score > 2 occurred in 6/139 patients (4%, 95% CI 2%–9%), 5 (83%) of whom had complications due to preoperative embolization. CONCLUSIONS The surgical treatment of brain AVMs in the TOBAS registry was curative in 88% of patients. The participation of more patients, surgeons, and centers in randomized trials is needed to definitively establish the role of surgery in the treatment of unruptured brain AVMs. Clinical trial registration no.: NCT02098252 ( ClinicalTrials.gov )

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Amira Al RaaisiKévin PrematEvelyne CormierEimad ShotarMehdi DrirVéronique MorelJean-Philippe SpanoHugues Pascal-MousselardLaetitia MorardetFrédéric ClarençonJacques Chiras
• Organismes : Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans European Radiology le 23/10/2020

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Résumé : Objectives Pelvic bone pathological lesions and traumatic fractures are a considerable source of pain and disability. In this study, we sought to evaluate the effectiveness of reinforced cementoplasty (RC) in painful and unstable lesions involving the pelvic bone in terms of pain relief and functional recovery. Methods All patients with neoplastic lesion or pelvic fracture for whom a pelvic bone RC was carried out between November 2013 and October 2017 were included in our study. All patients who failed the medical management, patients unsuitable for surgery, and patients with unstable osteolytic lesions were eligible to RC. Clinical outcome was evaluated with a 1-month and 6month post-procedure follow-up. The primary endpoint was local pain relief measured by the visual analogue scale (VAS). Results Twenty-two patients (18 females, 4 males; mean age of 65.4 ± 13.3 years [range 38-80]) presenting with painful and unstable pelvic lesions were treated by RC during the study period. Among the 22 patients, 8 patients presented with unstable pelvic fractures (3 patients with iliac crest fracture, 3 with sacral fractures, and the remaining 2 with peri-acetabular fractures). No procedure-related complications were recorded. All patients had significant pain relief and functional improvement at 1 month. One patient (4.5%) had suffered a secondary fracture due to local tumour progression. Conclusions Reinforced cementoplasty is an original minimally invasive technique that may help in providing pain relief and effective bone stability for neoplastic and traumatic lesions involving the pelvic bone. Key Points • Reinforced cementoplasty is feasible in both traumatic fractures and tumoural bone lesions of the pelvis. • Reinforced cementoplasty for pelvic bone lesions provides pain relief and functional recovery. • Recurrence of pelvic bone fracture was observed in 4.5% of the cases in our series.

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Fichiers liés : Reinforced cementoplasty for pelvic tumour lesions and pelvic traumatic fractures preliminary experience..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Flora SiegwaltLorène JeantetPierre LelongJordan MartinMarc GirondotPaco BustamanteAbdelwahab BenhalilouCéline MurgaleLucas AndreaniFrançois JacariaGuilhem CampistronAnthony LathièreCharlène BarotinGaëlle Buret-RochasPhilippe BarreGaëlle HielardAlexandre ArquéSidney RégisNicolas LecerfCédric FrouinFabien LefebvreNathalie AubertMosiah ArthusDenis EtienneJean-Pierre AllenouCésar DelnatteRachelle LafolleFlorence ThoborPascale ChevallierTao ChevallierMuriel LeporiCindy AssioClément GrandMarc BonolaYannick TursiPierre-Walter VarkalaStéphane MeslierAnthony LandreauYvon Le MahoC. HaboldJean-Patrice RobinDamien Chevallier
• Organismes : Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Ecologie, Société et Evolution (ex-Ecologie, Systématique et Evolution) LIttoral ENvironnement et Sociétés Institut universitaire de France La Rochelle Université Association POEMM Association POEMM Association POEMM Association POEMM Association POEMM Association POEMM Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Office de l'Eau Martinique Office de l'Eau Martinique Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie ACWAA Association ACWAA Association Biologie des Organismes et Ecosystèmes Aquatiques Direction de l'environnement de l'aménagement et du Logement - Martinique Unité Biodiversité et Environnement de la Martinique Biotope [Mèze] Association POEMM Biologie des Organismes et Ecosystèmes Aquatiques Association POEMM Association POEMM Association POEMM Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Auteur indépendant Auteur indépendant Association Naturaliste de Soutien Logistique À La Science Association Naturaliste de Soutien Logistique À La Science Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie Département Ecologie, Physiologie et Ethologie
• Publié dans Global Ecology and Conservation le 23/10/2020

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Résumé : Marine herbivores face rapid changes in the coastal ecosystems where they forage. In the Caribbean, the recent and fast expansion of the invasive phanerogam species Halophila stipulacea is threatening native seagrass ecosystems. So far, H. stipulacea is escaping most Caribbean herbivores, certainly because of its recent introduction or lower nutritional value. We investigated the impact of H. stipulacea invasion on fine-scale foraging habitat selection and food resource selection of immature green turtles at critical foraging sites in Les Anses d′Arlet, Martinique. The analysis of seagrass distribution and nutritional content, together with turtle behaviour and resource selection, showed that H. stipulacea may be of contrasting interest to green turtles. Compositional analysis confirmed the lower nutritional value of H. stipulacea compared to the native species, but the invasive species showed higher digestibility than native ones, which calls into question the energetic advantage of consuming the native plants over the exotic plant. Thus, although green turtles mostly selected the native seagrass Thalassia testudinum in multispecies seagrass beds, some individuals fed on H. stipulacea. Accordingly, in bays entirely invaded by H. stipulacea, one possibility for resident green turtles is to increase foraging on this species, but, if so, the consequences on their growth and survival still remain to be determined. As the expansion of H. stipulacea may have been facilitated by factors such as shipping, anchor scarring and fishing activities, protection of native seagrass beds and immature green turtles from human disturbances is urgently required to ensure the long-term adaptation of green turtles to this new foraging environment.

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Fichiers liés : 2022_Siegwalt_Global Ecology and Conservation.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Laure Peter-DerexFrédéric PhilippeauPierre GarnierNathalie André-ObadiaSébastien BoulogneHélène CatenoixPhilippe ConversLaure MazzolaMichel GouttardMaud EstebanJulia FontaineLaura MechtouffElodie OngTae-Hee ChoNorbert NighoghossianNathalie PerretonAnne TermozJulie HaesebaertAnne-Marie SchottMuriel RabilloudChristine PivotCarole DhelensAndrea FilipYves BerthezèneSylvain RheimsFlorent BoutitieLaurent Derex
• Organismes : Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Hôpital de la Croix-Rousse [CHU - HCL] Centre Hospitalier Fleyriat [Bourg en Bresse] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Fleyriat [Bourg en Bresse] Hospices Civils de Lyon Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Research on Healthcare Performance Research on Healthcare Performance Research on Healthcare Performance Research on Healthcare Performance Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Modeling & analysis for medical imaging and Diagnosis Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Research on Healthcare Performance
• Publié dans The Lancet Neurology le 27/10/2020

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Résumé : BACKGROUND: The incidence of early seizures (occurring within 7 days of stroke onset) after intracerebral haemorrhage reaches 30% when subclinical seizures are diagnosed by continuous EEG. Early seizures might be associated with haematoma expansion and worse neurological outcomes. Current guidelines do not recommend prophylactic antiseizure treatment in this setting. We aimed to assess whether prophylactic levetiracetam would reduce the risk of acute seizures in patients with intracerebral haemorrhage. METHODS: The double-blind, randomised, placebo-controlled, phase 3 PEACH trial was conducted at three stroke units in France. Patients (aged 18 years or older) who presented with a non-traumatic intracerebral haemorrhage within 24 h after onset were randomly assigned (1:1) to levetiracetam (intravenous 500 mg every 12 h) or matching placebo. Randomisation was done with a web-based system and stratified by centre and National Institutes of Health Stroke Scale (NIHSS) score at baseline. Treatment was continued for 6 weeks. Continuous EEG was started within 24 h after inclusion and recorded over 48 h. The primary endpoint was the occurrence of at least one clinical seizure within 72 h of inclusion or at least one electrographic seizure recorded on continuous EEG, analysed in the modified intention-to-treat population, which comprised all patients who were randomly assigned to treatment and who had a continuous EEG performed. This trial was registered at ClinicalTrials.gov, NCT02631759, and is now closed. Recruitment was prematurely stopped after 48% of the recruitment target was reached due to a low recruitment rate and cessation of funding. FINDINGS: Between June 1, 2017, and April 14, 2020, 50 patients with mild-to-moderate severity intracerebral haemorrhage were included: 24 were assigned to levetiracetam and 26 to placebo. During the first 72 h, a clinical or electrographic seizure was observed in three (16%) of 19 patients in the levetiracetam group versus ten (43%) of 23 patients in the placebo group (odds ratio 0·16, 95% CI 0·03-0·94, p=0·043). All seizures in the first 72 h were electrographic seizures only. No difference in depression or anxiety reporting was observed between the groups at 1 month or 3 months. Depression was recorded in three (13%) patients who received levetiracetam versus four (15%) patients who received placebo, and anxiety was reported for two (8%) patients versus one (4%) patient. The most common treatment-emergent adverse events in the levetiracetam group versus the placebo group were headache (nine [39%] vs six [24%]), pain (three [13%] vs ten [40%]), and falls (seven [30%] vs four [16%]). The most frequent serious adverse events were neurological deterioration due to the intracerebral haemorrhage (one [4%] vs four [16%]) and severe pneumonia (two [9%] vs two [8%]). No treatment-related death was reported in either group. INTERPRETATION: Levetiracetam might be effective in preventing acute seizures in intracerebral haemorrhage. Larger studies are needed to determine whether seizure prophylaxis improves functional outcome in patients with intracerebral haemorrhage. FUNDING: French Ministry of Health.

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Fichiers liés : 1-s2.0-S1474442222002356-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Thomas BittarPierre CarpentierJean-Philippe ChancelierJéro͂me Lonchampt
• Organismes : Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique Performance, Risque Industriel, Surveillance pour la Maintenance et l’Exploitation Optimisation et commande Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique
• Publié dans SIAM Journal on Optimization le 22/10/2020

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Résumé : The stochastic Auxiliary Problem Principle (APP) algorithm is a general Stochastic Approximation (SA) scheme that turns the resolution of an original optimization problem into the iterative resolution of a sequence of auxiliary problems. This framework has been introduced to design decomposition-coordination schemes but also encompasses many well-known SA algorithms such as stochastic gradient descent or stochastic mirror descent. We study the stochastic APP in the case where the iterates lie in a Banach space and we consider an additive error on the computation of the subgradient of the objective. In order to derive convergence results or efficiency estimates for a SA scheme, the iterates must be random variables. This is why we prove the measurability of the iterates of the stochastic APP algorithm. Then, we extend convergence results from the Hilbert space case to the Banach space case. Finally, we derive efficiency estimates for the function values taken at the averaged sequence of iterates or at the last iterate, the latter being obtained by adapting the concept of modified Fejér monotonicity to our framework.

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Fichiers liés : preprint_paper_ppa_v4.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2022
• Auteurs : Lucas GuilloAurelien AmiotMélanie SerreroRomain AltweggXavier RoblinCalina AtanasiuAnthony BuissonCatherine Le BerreCatherine ReenaersJean-Marc GornetDavid LaharieVered AbitbolAmélie BironBénédicte CaronStéphane NanceyAntoine ChupinAntoine BlainLucine VuittonLudovic CailloJulien KirchgesnerMaria NachuryLaurent Peyrin‐BirouletBenjamin ParienteLaurent BeaugeriePhillipe SeksikAnne BourrierArnaud BourrreilleAriadne DesjeuxGuillaume SavoyeStéphanie AuzouGuillaume CadiotAlban BenezechNicolas MathieuGeorgia MalamutKarine AmouriauxHédia BrixiMarion SimonDaniel BenitahPhilippe Ah-SouneMathurin FumeryGilles BoschettiClaire GayMathias VidonGinette FotsingBenoit CoffinCyrielle GillettaJean Marie ReimundMarie Bonnet-Dodel
• Organismes : Hôpital Nord [CHU - APHM] Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375) Service de gastro-entérologie [Henri Mondor AP-HP, Créteil] Hôpital Nord [CHU - APHM] Centre Hospitalier Régional Universitaire [Montpellier] Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne] Centre International de Recherche en Infectiologie Centre hospitalier Saint-Joseph [Paris] Service Hépato-Gastro-Entérologie [CHU Clermont-Ferrand] Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut des Maladies de l'Appareil Digestif Centre Hospitalier Universitaire de Liège Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Bordeaux Service de Gastro-entérologie [CHU Cochin] Hôpital universitaire Robert Debré [Reims] Hôpital de Hautepierre [Strasbourg] Interface de Recherche Fondamentale et Appliquée en Cancérologie Centre International de Recherche en Infectiologie Centre Hospitalier Lyon Sud [CHU - HCL] Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre] Université Paris-Saclay Institut Mutualiste de Montsouris Service de Gastro-Entérologie [CHRU Besançon] Centre Hospitalier Universitaire de Nîmes Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Institute for Translational Research in Inflammation - U 1286 Nutrition-Génétique et Exposition aux Risques Environnementaux Service d'Hépato-gastro-entérologie [CHRU Nancy] Autophagie infection et immunité - Autophagy Infection Immunity [CIRI] Centre Hospitalier Lyon Sud [CHU - HCL]
• Publié dans Digestive Diseases and Sciences le 01/11/2020

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Résumé : Background and aims: Patients with inflammatory bowel disease have an increased risk of venous thromboembolism (VTE) and cardiovascular disease (CVD). The study aims to determine the prevalence of CVD and VTE risk factors in a large population of patients with ulcerative colitis (UC). Methods: We conducted a cross-sectional study in 33 French and Belgium referral centers. A questionnaire was developed to explore self-reported risk factors for VTE and CVD, based on the latest international guidelines, in consecutive patients with UC. Results: A total of 1071 patients with UC were included. There were 539 women (50.3%), and the median age of patients was 44 years [32; 57]. The median disease duration was 10 years [6; 17]. In the cohort, 36.5% of patients reported no cardiovascular risk factor (CVRF) and 72% had ≤ 1 CVRF. Regarding cardiovascular risk markers (CVRM) 36.9% of patients reported no CVRM and 78% had ≤ 1 CVRM. Of the 1071 patients, 91.3% of patients reported no VTE strong risk factor and 96% had ≤ 1 VTE moderate risk factor. Conclusion: This is the first cohort specifically designed to assess both VTE and CVD risks in patients with UC. More than one third of patients with UC had no CVRF and around three quarters had ≤ 1 CVRF. In addition, more than nine out of ten patients had no VTE strong risk factor and ≤ 1 moderate risk factor. Physicians should be aware of these factors in their patients.

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