Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2022
• Auteurs : Loïc SanchezÉmilie BoulangerVéronique ArnalPierre BoisseryAlicia DalongevilleTony DejeanJulie DeterNacim GuellatiFlorian HolonJean-Baptiste JuhelPhilippe LenfantFabien LeprieurAlice ValentiniStéphanie ManelDavid Mouillot
• Organismes : MARine Biodiversity Exploitation and Conservation - MARBEC Centre d’Ecologie Fonctionnelle et Evolutive Institut méditerranéen d'océanologie Centre d’Ecologie Fonctionnelle et Evolutive Agence de l'eau Rhône Méditerranée Corse MARine Biodiversity Exploitation and Conservation - MARBEC SPYGEN [Le Bourget-du-Lac] Andromède Océanologie MARine Biodiversity Exploitation and Conservation - MARBEC Andromède Océanologie MARine Biodiversity Exploitation and Conservation - MARBEC Centre de Formation et de Recherche sur les Environnements Méditérranéens MARine Biodiversity Exploitation and Conservation - MARBEC SPYGEN [Le Bourget-du-Lac] MARine Biodiversity Exploitation and Conservation - MARBEC MARine Biodiversity Exploitation and Conservation - MARBEC Institut universitaire de France
• Publié dans Ecological Indicators le 01/11/2020

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Fichiers liés : 1-s2.0-S1470160X2200437X-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2022
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sanchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiJosep CasacubertaMatias ZurbriggenAntonio FernandezJose Angel Gomez RuizAndrea GennaroNikoletta PapadopoulouAnna LanzoniHanspeter Naegeli
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Fichiers liés : EFSA Journal - 2022 - - Evaluation of existing guidelines for their adequacy for the food and feed risk assessment of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2022
• Auteurs : Mailen Ortega-CuadrosTiago Lodi de SouzaRomain BerruyerSophie AligonSandra PelletierJean-Pierre RenouTatiana AriasClaire CampionThomas GuillemetteJerome VerdierPhilippe Grappin
• Organismes : Universidad de Antioquia = University of Antioquia [Medellín, Colombia] Universidad de Antioquia = University of Antioquia [Medellín, Colombia] Institut de Recherche en Horticulture et Semences Institut de Recherche en Horticulture et Semences Institut de Recherche en Horticulture et Semences Institut de Recherche en Horticulture et Semences Marie Selby Bot Gardens, Université Nice Sophia Antipolis - Faculté de Médecine Institut de Recherche en Horticulture et Semences Institut de Recherche en Horticulture et Semences Institut de Recherche en Horticulture et Semences Institut de Recherche en Horticulture et Semences
• Publié dans Plants le 27/10/2020

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Résumé : The transmission of seed-borne pathogens by the germinating seed is responsible for major crop diseases. The immune responses of the seed facing biotic invaders are poorly documented so far. The Arabidopsis thaliana/Alternaria brassicicola patho-system was used to describe at the transcription level the responses of germinating seeds and young seedling stages to infection by the necrotrophic fungus. RNA-seq analyses of healthy versus inoculated seeds at 3 days after sowing (DAS), stage of radicle emergence, and at 6 and 10 DAS, two stages of seedling establishment, identified thousands of differentially expressed genes by Alternaria infection. Response to hypoxia, ethylene and indole pathways were found to be induced by Alternaria in the germinating seeds. However, surprisingly, the defense responses, namely the salicylic acid (SA) pathway, the response to reactive oxygen species (ROS), the endoplasmic reticulum-associated protein degradation (ERAD) and programmed cell death, were found to be strongly induced only during the latter post-germination stages. We propose that this non-canonical immune response in early germinating seeds compared to early seedling establishment was potentially due to the seed-to-seedling transition phase. Phenotypic analyses of about 14 mutants altered in the main defense pathways illustrated these specific defense responses. The unexpected germination deficiency and insensitivity to Alternaria in the glucosinolate deficient mutants allow hypothesis of a trade-off between seed germination, necrosis induction and Alternaria transmission to the seedling. The imbalance of the SA and jasmonic acid (JA) pathways to the detriment of the JA also illustrated a non-canonical immune response at the first stages of the seedling.

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Fichiers liés : 2022_Ortega-Cuadros_plants-11-01708-1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/07/2022
• Auteurs : Cécile VittoriValentin ChardonStoil ChapkanskiPierre CarbonelJean-Philippe GoiranLaurent Schmitt
• Organismes : ARCHEORIENT - Environnements et sociétés de l'Orient ancien Laboratoire Image, Ville, Environnement Laboratoire Image, Ville, Environnement ARCHEORIENT - Environnements et sociétés de l'Orient ancien Laboratoire de géographie physique : Environnements Quaternaires et Actuels ARCHEORIENT - Environnements et sociétés de l'Orient ancien ARCHEORIENT - Environnements et sociétés de l'Orient ancien Laboratoire Image, Ville, Environnement

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• Type de publi. : Article dans une revue
• Date de publi. : 30/06/2022
• Auteurs : Johanna NoelAnne JouinotJérôme AlexandreGuillaume UlmannMarie BretagneZahra Castel-AjgalSixtine de PercinClémentine Vaquin-VillemineyMarie-Pierre RevelMichael PeyromaurePascaline Boudou-RouquetteJennifer ArrondeauIthar GataaJean-Philippe DurandFrançois GoldwasserOlivier Huillard
• Organismes : Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Institut Cochin Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Centre de Recherche des Cordeliers Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Institut Cochin Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Centre de Recherche des Cordeliers Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris]
• Publié dans Cancers le 21/10/2020

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Résumé : Background: Nivolumab improved patients’ survival in metastatic renal cell carcinoma (mRCC). We aimed to evaluate resting energy expenditure (REE) (i.e., patients’ basal metabolism) to predict efficacy. Methods: We conducted a monocentric, observational study of mRCC patients receiving nivolumab between October 2015 and May 2020. REE was measured prior to initiating immunotherapy using indirect calorimetry to determine hypo, normo and hypermetabolism. Primary endpoint was 6-month, progression-free survival (PFS), and secondary endpoints were response rate, PFS and overall survival (OS). Results: Of the 51 consecutive patients, 15 (29%) were hypermetabolic, 24 (47%) normometabolic, and 12 (24%) hypometabolic. The 6-month PFS was 15% for hypermetabolic patients and 65% for non-hypermetabolic patients (p < 0.01). In the multivariate analysis, hypermetabolism was the only baseline factor predicting 6-month PFS (OR 9.91, 95%CI [1.62–60.55], p = 0.01). Disease progression was noted as the best response in 73% of hypermetabolic patients and 26% of non-hypermetabolic patients (p = 0.02). Median PFS was 2.8 and 8.7 months (p < 0.01), and median OS was 20.2 and 35.1 months (p = 0.13) in the hypermetabolic and non-hypermetabolic groups, respectively. Conclusions: Our study identifies an association between mRCC patients’ energy expenditure and nivolumab efficacy. The measurement of REE by indirect calorimetry in routine practice could help identify patients at risk of nivolumab failure.

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Fichiers liés : cancers-14-03214.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/06/2022
• Auteurs : Anne-Lise BienvenuPatricia PaveseGilles LeboucherPierre BergerSandrine RouxAlexandre CharmillonLuc ForoniJean MenottiDavid LebeauxRémi MayanVéronique MondainChristine RobinPhilippe LespritSerge AlfandariSolen Kernéis
• Organismes : Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Synthèse de Molécules d'Intérêt Thérapeutique Université Claude Bernard Lyon 1 Hospices Civils de Lyon
• Publié dans Journal of Medical Microbiology le 25/10/2020

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Résumé : Introduction. Antifungal stewardship programmes are needed in healthcare facilities to limit the overuse or misuse of antifungals, which are responsible for an increase in antifungal resistance. Hypothesis/Gap Statement. Core recommendations for antifungal stewardship were published by the Mycoses Study Group Education and Research Consortium, while the Centers for Disease Control and Prevention (CDC) provided a Core Elements of Hospital Antibiotic Stewardship Programs checklist. The recommendations offer global core elements for best practices in antifungal stewardship, but do not provide a framework for the implementation of antifungal stewardship programmes in healthcare facilities. Aim. In line with the recommendations, it is of the utmost importance to establish a practical checklist that may be used to implement antifungal stewardship programmes. Methodology. The practical checklist was established by a national consensus panel of experts involved in antifungal stewardship activities. A preliminary checklist was sent to all experts. The final document was approved by the panel after discussion and the resolution of any disagreements by consensus. Results. The final checklist includes the following items: leadership support; actions to support optimal antifungal use; actions to monitor antifungal prescribing, use and resistance; and an education programme. Conclusion. This antifungal stewardship checklist offers opportunities for antifungal resistance containment, given that antifungal stewardship activities promote the optimal use of antifungals.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Guillaume CoutanceMatteo PozziMatthieu AubryElisabeth Hugon-ValletRaluca MocanLara ChalabreyssePhilippe PortranJean-François ObadiaOlivier ThaunatNicolas GirerdValérie DuboisLaurent Sebbag
• Organismes : Hôpital Louis Pradel [CHU - HCL] Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Hospices Civils de Lyon Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] Hospices Civils de Lyon Groupement Hospitalier Lyon-Est Hôpital Louis Pradel [CHU - HCL] Hospices Civils de Lyon Hospices Civils de Lyon Centre International de Recherche en Infectiologie Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI] Université Claude Bernard Lyon 1 Service de Transplantation, Néphrologie et Immunologie Clinique [Lyon] Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Etablissement français du sang - Auvergne-Rhône-Alpes Hôpital Louis Pradel [CHU - HCL]
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : Introduction: De novo anti-HLA donor specific antibodies (DSA) have been inconsistently associated with cardiac allograft vasculopathy (CAV) and long-term mortality. We tested whether C3d-binding de novo DSA were associated with CAV or long-term-survival. Methods: We included 282 consecutive patients without preformed DSA on coronary angiography between 2010 and 2012. Angiographies were classified according to CAV ISHLT grading. The primary outcome was a composite criterion of severe CAV or mortality. As the impact of de novo antibodies should be assessed only after appearance, we used a Cox regression with time-dependent covariables. Results: Of the 282 patients, 51(18%) developed de novo DSA during follow-up, 29 patients had DSA with C3d-binding ability (DSA+C3d+), and 22 were without C3d-binding ability (DSA+C3d-). Compared with patients without DSA, DSA+C3d+ patients had an increased risk for the primary outcome of severe CAV or mortality (adjusted HR = 4.31 (2.40–7.74) p < 0.001) and long-term mortality (adjusted HR = 3.48 (1.97–6.15) p < 0.001) whereas DSA+C3d- did not (adjusted HR = 1.04 (0.43–2.47) p = 0.937 for primary outcome and HR = 1.08 (0.45–2.61) p = 0.866 for mortality). Conclusion: According to this large monocentric study in heart transplant patients, donor specific antibodies were associated with worse clinical outcome when binding complement. DSA and their complement-binding ability should thus be screened for to optimize heart transplant patient follow-up.

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Fichiers liés : jcm-11-03731.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Hui YangPhilippe CiaisJean-Pierre WigneronJérôme ChaveOliver CartusXiuzhi ChenSassan S SaatchiJulia GreenYuanyuan HuangEmilie JoetzjerHeather KayDavid MakowskiFabienne MaignanMaurizio SantoroShengli TaoQingling SunYitong Yao
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Evolution et Diversité Biologique Gamma Remote Sensing Research and Consulting AG National Sun Yat-sen University Southwest Forestry University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Commonwealth Scientific and Industrial Research Organisation [Australia] Centre national de recherches météorologiques Aberystwyth University Mathématiques et Informatique Appliquées Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Gamma Remote Sensing Research and Consulting AG Evolution et Diversité Biologique Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] National Sun Yat-sen University
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : The 2015/16 El Niño brought severe drought and record-breaking temperatures in the tropics. Here, using satellite-based L-band microwave vegetation optical depth, we mapped changes of above-ground biomass (AGB) during the drought and in subsequent years up to 2019. Over more than 60% of drought-affected intact forests, AGB reduced during the drought, except in the wettest part of the central Amazon, where it declined 1 y later. By the end of 2019, only 40% of AGB reduced intact forests had fully recovered to the predrought level. Using random-forest models, we found that the magnitude of AGB losses during the drought was mainly associated with regionally distinct patterns of soil water deficits and soil clay content. For the AGB recovery, we found strong influences of AGB losses during the drought and of γ . γ is a parameter related to canopy structure and is defined as the ratio of two relative height (RH) metrics of Geoscience Laser Altimeter System (GLAS) waveform data—RH25 (25% energy return height) and RH100 (100% energy return height; i.e., top canopy height). A high γ may reflect forests with a tall understory, thick and closed canopy, and/or without degradation. Such forests with a high γ ( γ ≥ 0.3) appear to have a stronger capacity to recover than low- γ ones. Our results highlight the importance of forest structure when predicting the consequences of future drought stress in the tropics.

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Fichiers liés : 2022_Yang_PNAS.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Gabriel IchimBenjamin GibertSahil AdriouchCatherine BrennerNathalie DavoustSolange DesagherDavid DevosSvetlana DokudovskayaLaurence DubrezJérôme EstaquierGermain GilletIsabelle GuénalPhilippe JuinGuido KroemerPatrick LegembreRomain LevayerStéphen ManonPatrick MehlenOlivier MeuretteOlivier MicheauBernard MignotteFlorence Nguyen-KhacNikolay PopgeorgievJean-Luc PoyetMuriel PriaultJean-Ehrland RicciFranck RiquetSantos A. SusinMagali SuzannePierre VacherLudivine WalterBertrand Mollereau
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques Laboratoire de biologie et modélisation de la cellule Institut de Génétique Moléculaire de Montpellier Lille Neurosciences & Cognition - U 1172 Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques Lipides - Nutrition - Cancer [Dijon - U1231] Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire Centre de Recherche en Cancérologie de Lyon Hospices Civils de Lyon Laboratoire de génétique et biologie cellulaire École Pratique des Hautes Études Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Centre de Recherche des Cordeliers Contrôle de la Réponse Immune B et des Lymphoproliférations Cellules Souches et Développement / Stem Cells and Development Institut de biochimie et génétique cellulaires Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire de génétique et biologie cellulaire École Pratique des Hautes Études Centre de Recherche des Cordeliers CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche en Cancérologie de Lyon Institut universitaire de France Immunologie humaine, physiopathologie & immunothérapie Institut de biochimie et génétique cellulaires Centre méditerranéen de médecine moléculaire Universiteit Gent = Ghent University = Université de Gand Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 Centre de Recherche des Cordeliers Centre de Biologie Intégrative Unité de biologie Moléculaire, Cellulaire et du Développement Actions for OnCogenesis understanding and Target Identification in ONcology Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule
• Publié dans Biomolecules le 25/10/2020

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Résumé : Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated cell death still remain to be elucidated in specific cell subtypes and disease conditions, many predicted that research into cell death was inexorably reaching a plateau. However, this was not the case since the last decade saw a multitude of cell death modalities being described, while harnessing their therapeutic potential reached clinical use in certain cases. In line with keeping research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN). The research conducted by FCDRN is at the leading edge of emerging topics such as non-apoptotic functions of apoptotic effectors, paracrine effects of cell death, novel canonical and non-canonical mechanisms to induce apoptosis in cell death-resistant cancer cells or regulated forms of necrosis and the associated immunogenic response. Collectively, these various lines of research all emerged from the study of apoptosis and in the next few years will increase the mechanistic knowledge into regulated cell death and how to harness it for therapy.

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Fichiers liés : biomolecules-12-00901-v2.pdf

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• Type de publi. :
• Date de publi. : 28/06/2022
• Auteurs : Philippe ColombanBurcu KirmiziJean-Baptiste ClaisMichele Gironda
• Organismes : De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies Laboratoire de Dynamique Interactions et Réactivité Laboratoire de Physique de la Matière Condensée Yildiz Technical University Musée du Louvre XGLab S.R.L – Bruker, Milan

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Résumé : Gilt-decorated porcelains of Joseph Coteau and Philippe Parpette, unifying metal and ceramic enamel techniques, had been produced from ~1770 to 1800 but this production was rare and poorly documented [1,2]. Enamelled decorations of these artefacts display gold foils (paillon in French) coated with lead-based transparent and opaque enamels fired on the porcelain glaze. Rare items were being produced at different factories (Sèvres Royal Factory, Duc d’Artois Factory) and it is reported that some copies were made during the 19th century. This study presents the first (non-destructive) Raman and pXRF study of four cups and two pairs of vases. In these artefacts, decorations made of enamelled gold foil were applied both on soft-paste (Parpette and Coteau production) and hard-paste (Coteau production) porcelain body. The analyses showed the differences in the glazing technology used. The bonding between the gold foil and the glaze was obtained by addition of arsenic and possibly some other fluxes (boron, bismuth?). The use of cassiterite opacifier seems to be characteristic of Coteau’s technique. [1] R. de Plinval de Guillebon, Un phénomène périodique: la mode du décor d’or appliqué et d’émail sur la porcelaine française (XVIIe-XIXe siècles), Rev. Soc. Amis Sèvres 1 (1992) 7-22. [2] T. Preaud, Sèvres enamelled porcelain: Eight dies (and a quarrel) rediscovered, The Burlington Magazine 128 [999] (1986) 391-397.

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Fichiers liés : INART 2022_Coteau.pdf

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