Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Sara ThietartAriane BoumendilDominique PateronBertrand GuidetH. ValletBertrand GuidetDominique PateronErwan DebucYouri YordanovAriane BoumendilCaroline ThomasDidier DreyfussJean-Damien RicardPatrick BrunChristophe LeroyYves CohenFrédéric AdnetMaguy WoimantJean-Paul MiraBenoît DoumencKhalil TkuThomas SimilowskiBruno RiouPierre HausfaterSamuel DelermeJean-Pierre QuenotDidier HonnartJean-François TimsitPierrick GuérinFrançoise CarpentierMaxime MaignanFoued MakhlouJean-François PousselYohann PicardFrançois BraunPauline TrognonFrançois FourrierPatrick GoldsteinMarie GirotPierre GosselinFrancesco SantoliPierre CharestanClaire PolyHervé MentecCatherine Le GallKarima SahraouiChristophe BaillardNicolas JavaudBenoît MissetMaité Garrouste-OrgeasOlivier GanansiaFrançois-Xavier RooryckJean Luc AimAbudlrazak El RifaiJean ReignierLaurent Martin-LefevrePhilippe FradinClaire MauriatEmelyne CwicklinskiMichel SlamaHervé DupontChristine AmmiratiJustine GallouMuriel FartoukhMichel DjibrePatrik RayEdwin RouffBertrand SouweineAli Ait HssainJeannot SchmidtDaniel PicFarès MoustafaAlain MercatNicolas LerollePierre-Marie RoyFrédéric BaudPatrick PlaisanceSophie MontagnonBertrand GalichonMichel WolffBruno MourvillierEnrique CasalinoChristophe ChoquetJulien BernardGaëlle JuillienJean-Yves FagonEmmanuel GuerotPhilippe JuvinAnabela PatzakBruno VerdièreVincent IoosMarie-Clément KoukaAudrey BerthoumieuChristian RichardRaphael MauriceSophie SarnelStéphane DiezAntoine Vieillard BaronSébastien BeauneJulie GrenetSylvie AzeradGuillaume LeblancTabassome Simon
• Organismes : CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre d'Immunologie et des Maladies Infectieuses CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Musée du Louvre Hôpital Louis Mourier - AP-HP [Colombes] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Hôpital d'instruction des Armées Percy Assistance publique - Hôpitaux de Paris (AP-HP) Hôpital Avicenne [AP-HP] Hôpital Avicenne [AP-HP] SAMU 93 [Bobigny] Marqueurs cardiovasculaires en situation de stress Hôpital Avicenne [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche clinique Biomarqueurs d’urgence et de réanimation Centre d'Immunologie et des Maladies Infectieuses Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Département de Médecine d'Urgence - Centre Régional Universitaire des Urgences (CRUU) (CHU de Dijon) AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution Service d'accueil des urgences médicales Université Grenoble Alpes Service de Soins Intensifs [CHR Metz-Thionville] Centre hospitalier régional de Metz-Thionville Université Henri Poincaré - Nancy 1 Hôpital Roger Salengro [Lille] Samu du Nord–pôle de l’urgence [Lille] Department of Emergency [Lille] Hôpital Robert Ballanger [Aulnay-sous-Bois] Hôpital Robert Ballanger [Aulnay-sous-Bois] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Hôpital Cochin [AP-HP] Hôpital Louis Mourier - AP-HP [Colombes] Centre de référence national des angiœdèmes Université Paris Cité Centre Hospitalier Universitaire de Liège Institut hospitalier Franco-Britannique [Levallois-Perret] Centre hospitalier Saint-Joseph [Paris] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Annals of Intensive Care le 23/10/2020

---

Résumé : Abstract Background Little is known about the impact of hospital trajectory on survival and functional decline of older critically ill patients. We evaluate 6-month outcomes after admission to: intensive care units (ICU), intermediate care units (IMCU) or acute medical wards (AMW). Methods Data from the randomised prospective multicentre clinical trial ICE-CUB2 was secondarily analysed. Inclusion criteria were: presenting at emergency departments in critical condition; age ≥ 75 years; activity of daily living (ADL) ≥ 4; preserved nutritional status; and no active cancer. A Cox model was fitted to compare survival according to admission destination adjusting for patient characteristics. Sensitivity analysis using multiple imputation for missing data and propensity score matching were performed. Results Among 3036 patients, 1675 (55%) were women; median age was 85 [81–99] years; simplified acute physiology score (SAPS-3) 62 [55–69]; 1448 (47%) were hospitalised in an ICU, 504 in IMCU (17%), and 1084 (36%) in AMW. Six-month mortality was 629 (44%), 155 (31%) and 489 (45%) after admission in an ICU, IMCU and AMW ( p < 0.001), respectively. In multivariate analysis, AMW admission was associated with worse 6-month survival (HR 1.31, 95% CI 1.04–1.63) in comparison with IMCU admission, after adjusting for age, gender, comorbidities, ADL, SAPS-3 and diagnosis. Survival was not significantly different between patients admitted in an ICU and an IMCU (HR 1.17, 95% CI 0.95–1.46). Sensitivity analysis using multiple imputation for missing data and propensity score matching found similar results. Hospital destination was not significantly associated with the composite criterion loss of 1-point ADL or mortality. Physical and mental components of the 12-Item Short-Form Health Survey were significantly lower in the acute medical ward group (34.3 [27.5–41.7], p = 0.037 and 44.3 [38.6–48.6], p = 0.028, respectively) than in the ICU group (34.7 [28.4–45.3] and 45.5 [40.0–50.0], respectively) and IMCU group (35.7 [29.7–43.8] and 44.5 [39.7–48.4], respectively). Conclusions Admission in an AMW was associated with worse 6-month survival in older critically ill patients in comparison with IMCU admission, with no difference of survival between ICU and IMCU admission. There were no clinically relevant differences in quality of life in each group. These results should be confirmed in specific studies and raise the question of dedicated geriatric IMCUs.

---

Fichiers liés : s13613-022-01042-4.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Jean-Michel TorrentiOuali AmiriLaury Barnes-DavinFrédéric BougrainSandrine BraymandBogdan CazacliuJohan ColinAmaury CudevillePatrick DanglaAssia DjerbiMathilde DoutreleauAdélaïde FerailleMarielle GueguenXavier GuillotYunlu HouLaurent IzoretYvan-Pierre JacobJena JeongJean David Lau Hiu HoongPierre-Yves MahieuxJonathan Mai-NhuHeriberto MartinezVincent MeyerVincent MorinThomas PerninJean-Marc PotierLaurent PoulizacPatrick RougeauMyriam SaadéLucie SchmittThierry SedranMarie SerengAnthony SoiveGlaydson Symoes dos ReysPhilippe TurcryVincent Le Cam
• Organismes : Département Matériaux et Structures Institut de Recherche en Génie Civil et Mécanique Centre Scientifique et Technique du Bâtiment Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Granulats et Procédés d'Elaboration des Matériaux Laboratoire Navier UMR Matériaux pour une construction durable Centre Scientifique et Technique du Bâtiment Génie civil et Energétique Comportement Physico-chimique et Durabilité des Matériaux Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Comportement Physico-chimique et Durabilité des Matériaux Matériaux pour Infrastructure de Transport Formulation, Microstructure, Modélisation et Durabilité des Matériaux de Construction Granulats et Procédés d'Elaboration des Matériaux Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Statistical Inference for Structural Health Monitoring Structure et Instrumentation Intégrée
• Publié dans Case Studies in Construction Materials le 30/11/2015

---

Fichiers liés : The FastCarb project.pdf

---

Source

---

• Type de publi. : Rapport
• Date de publi. : 01/12/2022
• Auteurs : Carole CarantaMathilde CausseFabien NoguéAnnabelle DéjardinEmilie GentiliniPhilippe DebaekeLaurent HazardSophie Le PerchecStéphane LemariéGuy RichardPeter RogowskyMarie-Violaine Tatry
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Génétique et Amélioration des Fruits et Légumes Institut Jean-Pierre Bourgin - Sciences du végétal Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt Direction pour la Science Ouverte AGroécologie, Innovations, teRritoires AGroécologie, Innovations, teRritoires Direction pour la Science Ouverte Laboratoire d'Economie Appliquée de Grenoble Direction de l'Expertise scientifique collective, de la Prospective et des Etudes Reproduction et développement des plantes Direction pour la Science Ouverte

---

Fichiers liés : ETUDE EDITION du GENOME et AGROECOLOGIE_VF.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Valentin CostesAurélie Chaulot-TalmonEli SellemEli SellemAnne Aubert-FrambourgLuc JouneauLuc JouneauChris HozéSébastien FritzMekki BoussahaChrystelle Le DanvicMarie-Pierre SanchezDidier BoichardLaurent SchiblerHélène JammesFlorence JaffrezicHélène Kiefer
• Organismes : Allice Biologie de la Reproduction, Environnement, Epigénétique & Développement Génétique Animale et Biologie Intégrative Biologie de la Reproduction, Environnement, Epigénétique & Développement Allice Biologie de la Reproduction, Environnement, Epigénétique & Développement Biologie de la Reproduction, Environnement, Epigénétique & Développement Biologie de la Reproduction, Environnement, Epigénétique & Développement Biologie de la Reproduction, Environnement, Epigénétique & Développement Biologie de la Reproduction, Environnement, Epigénétique & Développement Génétique Animale et Biologie Intégrative Allice Génétique Animale et Biologie Intégrative Allice Génétique Animale et Biologie Intégrative Allice Génétique Animale et Biologie Intégrative Génétique Animale et Biologie Intégrative Allice Biologie de la Reproduction, Environnement, Epigénétique & Développement Génétique Animale et Biologie Intégrative Biologie de la Reproduction, Environnement, Epigénétique & Développement
• Publié dans Clinical Epigenetics le 23/10/2020

---

Résumé : Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial insemination represent a relevant model in this field, as the broad dissemination of bull semen considerably alleviates confounding factors and enables the precise assessment of male fertility. This study was therefore designed to assess the potential for sperm DNA methylation to predict bull fertility. A unique collection of 100 sperm samples was constituted by pooling 2–5 ejaculates per bull from 100 Montbéliarde bulls of comparable ages, assessed as fertile ( n = 57) or subfertile ( n = 43) based on non-return rates 56 days after insemination. The DNA methylation profiles of these samples were obtained using reduced representation bisulfite sequencing. After excluding putative sequence polymorphisms, 490 fertility-related differentially methylated cytosines (DMCs) were identified, most of which were hypermethylated in subfertile bulls. Interestingly, 46 genes targeted by DMCs are involved in embryonic and fetal development, sperm function and maturation, or have been related to fertility in genome-wide association studies; five of these were further analyzed by pyrosequencing. In order to evaluate the prognostic value of fertility-related DMCs, the sperm samples were split between training ( n = 67) and testing ( n = 33) sets. Using a Random Forest approach, a predictive model was built from the methylation values obtained on the training set. The predictive accuracy of this model was 72% on the testing set and 72% on individual ejaculates collected from an independent cohort of 20 bulls. This study, conducted on the largest set of bull sperm samples so far examined in epigenetic analyses, demonstrated that the sperm methylome is a valuable source of male fertility biomarkers. The next challenge is to combine these results with other data on the same sperm samples in order to improve the quality of the model and better understand the interplay between DNA methylation and other molecular features in the regulation of fertility. This research may have potential applications in human medicine, where infertility affects the interaction between a male and a female, thus making it difficult to isolate the male factor.

---

Fichiers liés : s13148-022-01275-x.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Ali AbbasSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelLara AbsilKamal Abu JabalHiba Abu ZayyadSubhash AcharyaAndrew AckerShingo AdachiElisabeth AdamEnrico AdrianoDiana AdriãoSaleh Al AgeelShakeel AhmedMarina AielloKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimTala Al-DabbousAbdulrahman Al-FaresRazi AlalqamAngela AlbertiSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreHuda AlfoudriAdam AliImran AliNaseem Ali ShahNaseem Ali SheikhKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesMaria AmaralNur AmiraHeidi AmmerlaanPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoKazi Rubayet AnwarArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayAna ArocaLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalMotohiro AsakiAngel AsensioElizabeth AshleyMuhammad AshrafNamra AsifMohammad AsimJean Baptiste AssieAmirul AsyrafAnika AtiqueA. AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenNadia BaigJ. Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanValeria BalanFirouzé Bani-SadrRenata BarbalhoNicholas Yuri BarbosaWendy BarclaySaef Umar BarnettMichaela BarnikelHelena BarrasaAudrey BarreletCleide BarrigotoMarie BartoliCheryl BartoneJoaquín BaruchMustehan BashirRomain BasmaciMuhammad Fadhli Hassin BasriDenise BattagliniJules BauerDiego Fernando Bautista RinconDenisse Bazan DowAbigail BeaneAlexandra BedossaKer Hong BeeHusna BegumSylvie BehilillKarine BeirutiAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameBeatriz Amorim BeltrãoMarine BeluzeNicolas BenechLionel Eric BenjimanDehbia BenkerrouSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginJosé Luis Bernal SobrinoGiulia BertoliLorenzo BertolinoSimon BessisAdam BetzSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarIsabella BianchiClaudia BiancoFarah Nadiah BidinMoirangthem Bikram SinghFelwa Bin HumaidMohd Nazlin Bin KamarudinFrançois BissuelPatrick BistonLaurent BitkerJonathan BittonPablo Blanco-SchweizerCatherine BlierFrank BloosMathieu BlotLucille BlumbergFilomena BocciaLaetitia BodenesAlice BogaartsDebby BogaertAnne-Hélène BoivinPierre-Adrien BolzeFrançois BompartPatrizia BonelliAurelius BonfasiusDiogo BorgesRaphaël BorieHans Martin BosseElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDounia BouhmaniDamien BouhourKevin BouillerLaurence BouilletCamile BouisseThipsavanh BounphiengsyLatsaniphone BountthasavongAnne-Sophie BoureauJohn BourkeMaude BouscambertAurore BousquetJason BouziotisBianca BoxmaMarielle Boyer-BesseyreMaria BoylanFernando Augusto BozzaAxelle BraconnierCynthia BragaTimo BrandenburgerFilipa Brás MonteiroLuca BrazziDorothy BreenPatrick BreenKathy BrickellAlex BrowneShaunagh BrowneNicolas BrozziSonja Hjellegjerde BrunvollMarjolein Brusse-KeizerNina BuchteleChristian BuesaquilloPolina BugaevaMarielle BuissonDanilo BuonsensoErlina BurhanAidan BurrellIngrid BustosDenis ButnaruAndré CabieSusana CabralEder CaceresCyril CadozMia CallahanKate CalligyJose Andres CalvacheCaterina CaminitiJoão CamõesValentine CampanaPaul CampbellJosie CampisiCecilia CanepaMireia CanteroPauline Caraux-PazSheila CárcelChiara Simona CardellinoFilipa CardosoFilipe CardosoNelson CardosoSofia CardosoSimone CarelliFrancesca CarlacciNicolas CarlierThierry CarmoiGayle CarneyInês CarquejaMarie-Christine CarretFrançois Martin CarrierIda CarrollGail CarsonLeonor CarvalhoMaire-Laure CasanovaMariana CascãoSiobhan CaseyJosé CasimiroBailey CassandraSilvia CastañedaNidyanara CastanheiraGuylaine Castor-AlexandreHenry CastrillónIvo CastroAna CatarinoFrançois-Xavier CatherinePaolo CattaneoRoberta CavalinGiulio Giovanni CavalliAlexandros CavayasAdrian CeccatoMinerva Cervantes-GonzalezAnissa ChairCatherine ChakveatzeAdrienne ChanMeera ChandChristelle Chantalat AugerJean-Marc ChapplainJulie ChasAllegra ChatterjeeMobin ChaudryJonathan Samuel Chávez IñiguezAnjellica ChenYih-Sharng ChenMatthew Pellan ChengAntoine CheretAlfredo Antonio ChettaThibault ChiarabiniJulian ChicaSuresh Kumar ChidambaramLeong Chin ThoCatherine ChirouzeDavide ChiumelloHwa Jin ChoSung-Min ChoBernard CholleyDanoy ChommanamMarie-Charlotte ChopinTing Soo ChowYock Ping ChowNathaniel ChristyHiu Jian ChuaJonathan ChuaJose Pedro CidadeJosé Miguel Cisneros HerrerosBarbara Wanjiru CitarellaAnna CiulloEmma ClarkeJennifer ClarkeRolando Claure-Del GranadoSara ClohiseyPerren CobbCassidy CodanCaitriona CodyAlexandra CoelhoMegan ColesGwenhaël ColinMichael CollinsSebastiano Maria ColomboPamela CombsMarie ConnorAnne ConradSofía ContrerasElaine ConwayGraham CookeMary CoplandHugues CordelAmanda CorleySabine CornelisAlexander Daniel CornetArianne Joy CorpuzAndrea CortegianiGrégory CorvaisierEmma CostiganCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseRachel CreganCharles Crepy D’orleansSabine CroonenGloria CrowlJonathan CrumpClaudina CruzJuan Luis Cruz BermJaime Cruz RojoMarc CseteAlberto CucinoAilbhe CullenMatthew CummingsGer CurleyGerard CurleyElodie CurlierColleen CurranPaula CustodioFederico D’amicoFrédérick D’aragonEric D’ortenzioAna da Silva FilipeCharlene da SilveiraAl-Awwab DabalizAndrew DagensJohn Arne DahlDarren DahlyHeidi DaltonJo DaltonSeamus DalyNick DanemanCorinne DanielEmmanuelle DankwaJorge DantasMark de BoerGillian de LoughryDiego de MendozaEtienne de MontmollinRafael Freitas de Oliveira FrançaAna Isabel de Pinho OliveiraRosanna de RosaCristina de RoseThushan de SilvaPeter de VriesJillian DeaconDavid DeanAlexa DebardBianca DebenedictisMarie-Pierre DebrayNathalie DecastroWilliam DechertLauren DeconninckRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneNathalie DelfosIonna DeligiannisAndrea Dell’amoreChristelle DelmasPierre DelobelCorine DelsingElisa DemonchyEmmanuelle DenisDominique DeplanquePieter DepuydtMehul DesaiDiane DescampsMathilde DesvalléesSanti DewayantiPathik DhangerAlpha DialloSylvain DiamantisAndré DiasAndrea DiasJuan Jose DiazPriscila DiazRodrigo DiazKévin DidierJean-Luc DiehlWim DieperinkJérôme DimetVincent DinotFara DiopAlphonsine DioufYael DishonFélix DjossouAnnemarie DochertyHelen DohertyArjen DondorpAndy DongChristl DonnellyMaria DonnellyChloe DonohueSean DonohueYoann DonohuePeter DoranCéline DorivalPhouvieng DouangdalaJames Joshua DouglasRenee DoumaNathalie DournonTriona DownerJoanne DowneyMark DowningTom DrakeAoife DriscollAmiel DrorMurray DrydenClaudio Duarte FonsecaVincent DubéeFrançois DubosAudrey Dubot-PérèsAlexandre DucancelleToni DuculanSusanne DudmanAbhijit DuggalPaul DunandJake DunningMathilde DuplaixEmanuele Durante-MangoniLucian DurhamBertrand DussolJuliette DuthoitXavier DuvalAnne Margarita Dyrhol-RiiseSim Choon EanMarco Echeverria-VillalobosGiorgio EconomopoulosMichael EdelsteinSiobhan EganLinn Margrete EggesbøCarla EiraMohammed El SanharawiSubbarao ElapavaluruBrigitte ElharrarJacobien EllerbroekMerete Ellingjord-DalePhilippine EloyTarek ElshazlyIqbal ElyazarIsabelle EnderleTomoyuki EndoChan Chee EngIlka EngelmannVincent EnoufOlivier EpaulardMartina EscherMariano EsperattiHélène EsperouMarina Esposito-FareseJoão EstevãoManuel EtienneNadia EttalhaouiAnna Greti EverdingMirjam EversIsabelle FabreMarc FabreAmna FaheemArabella FahyCameron FairfieldZul FakarKomal FareedPedro FariaAhmed FarooqHanan FateenaArie Zainul FatoniKarine FaureRaphaël FavoryMohamed FayedNiamh FeelyLaura FeeneyJorge FernandesMarília Andreia FernandesSusana FernandesFrançois-Xavier FerrandEglantine Ferrand DevougeJoana FerrãoCarlo FerrariMário FerrazBenigno FerreiraIsabel FerreiraSílvia FerreiraRicard Ferrer-RocaNicolas FerriereCéline FickoClaudia Figueiredo-MelloWilliam FinlaysonJuan FiordaThomas FlamentClara FlateauTom FletcherLetizia Lucia FlorioBrigid FlynnDeirdre FlynnFederica FogliazzaClaire FoleyJean FoleyVictor FominTatiana FonsecaPatricia FontelaSimon ForsythDenise FosterGiuseppe FotiErwan FournRobert FowlerMarianne FraherDiego Franch-LlasatChristophe FraserJohn FraserMarcela Vieira FreireAna Freitas RibeiroCraig FrenchCaren FriedrichRicardo FritzStéphanie FryNora FuentesMasahiro FukudaG ArginValérie GaborieauRostane GaciMassimo GagliardiJean-Charles GagnardNathalie GagnéAmandine Gagneux-BrunonSérgio GaiãoLinda Gail SkeiePhil GallagherElena Gallego CurtoCarrol GambleYasmin GaniArthur GaranRebekha GarciaNoelia García BarrioJulia Garcia-DiazEsteban Garcia-GalloNavya GarimellaFederica GarofaloDenis GarotValérie GarraitBasanta GauliNathalie GaultAisling GavinAnatoliy GavrylovAlexandre GaymardJohannes GebauerEva GeraudLouis Gerbaud MorlaesNuno GermanoPraveen Kumar GhisulalJade GhosnMarco GianiCarlo GiaquintoJess GibsonTristan GiganteMorgane GilgElaine GilroyGuillermo GiordanoMichelle GirvanValérie GissotJesse GitakaGezy GiwangkancanaDaniel GlikmanPetr GlybochkoEric GnallGeraldine GocoFrançois GoehringerSiri GoepelJean-Christophe GoffardJin Yi GohJonathan GolobRui GomesKyle GomezJoan Gómez-JunyentMarie GominetBronner GonçalvesAlicia GonzalezPatricia GordonYanay GorelikIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokMargarite GrableJeronimo GrafEdward Wilson GrandinPascal GranierGiacomo GrasselliLorenzo GrazioliChristopher GreenCourtney GreeneWilliam GreenhalfSegolène GreffeDomenico Luca GriecoMatthew GriffeeFiona GriffithsIoana GrigorasAlbert GroenendijkAnja Grosse LordemannHeidi GrunerYusing GuFabio GuarracinoJérémie GuedjMartin GuegoDewi GuellecAnne-Marie GuerguerianDaniela GuerreiroRomain GueryAnne GuillaumotLaurent GuilleminaultThomas GuimardMarieke HaalboomDaniel HaberHannah HabrakenAli HachemiAmy HackmannNadir HadriFakhir HaidriSheeba HakakAdam HallMatthew HallSophie HalpinJawad HameedAnsley HamerRaph HamersRebecca HamidfarBato HammarströmTerese HammondLim Yuen HanRashan HaniffaKok Wei HaoHayley HardwickEwen HarrisonJanet HarrisonSamuel Bernard Ekow HarrisonAlan HartmanMohd Shahnaz HasanJunaid HashmiMadiha HashmiAilbhe HayesLeanne HaysJan HeermanLars HeggelundRoss HendryMartina HennessyAquiles Henriquez-TrujilloMaxime HentzienJaime Hernandez-MontfortDaniel HerrAndrew HersheyLiv HesstvedtAstarini HidayahDawn HigginsEibhilin HigginsRita HinchionSamuel HintonHiroaki HiraiwaHaider HirkaniHikombo HitotoAntonia HoYi Bin HoAlexandre HoctinIsabelle HoffmannWei Han HohOscar HoitingRebecca HoltJan Cato HolterPeter HorbyJuan Pablo HorcajadaKoji HoshinoKota HoshinoIkram HouasCatherine HoughStuart HoulthamJimmy Ming-Yang HsuJean-Sébastien HulotStella HuoIqbal HussainSamreen IjazHajnal-Gabriela IllesPatrick ImbertMohammad ImranRana Imran SikanderAftab ImtiazHugo InácioCarmen Infante DominguezYun Sii IngElias IosifidisMariachiara IppolitoSarah IsgettTiago IsidoroNadiah IsmailMargaux IsnardMette Stausland IstreJunji ItaiAsami ItoDaniel IvulichDanielle JaafarSalma JaafouraJulien JabotClare JacksonNina JamiesonPierre JaquetWaasila JassatColine Jaud-FischerStéphane JaureguiberryJeffrey JavidfarDenise JaworskyFlorence JegoAnilawati Mat JelaniSynne JenumRuth Jimbo-SotomayorOng Yiaw JoeRuth GarcíaSilje Bakken JørgensenCédric JosephMark JosephSwosti JoshiMercé JourdainPhilippe JouvetJennifer JuneAnna JungHanna JungDafsah JuzarOuifiya KafifFlorentia KaguelidouNeerusha KaisbainThavamany KaleesvranSabina KaliAlina KalicinskaKarl Trygve KallebergSmaragdi KalomoiriMuhammad Aisar Ayadi KamaluddinZul Amali Che KamaruddinNadiah KamarudinKavita KamineniDarshana Hewa KandambyChris KandelKong Yeow KangDarakhshan KanwalDyah KanyawatiPratap KarpayahTodd KarsiesChristiana KartsonakiDaisuke KasugaiAnant KatariaKevin KatzAasmine KaurTatsuya KawasakiChristy KayHannah KeaneSeán KeatingPulak KediaAndrea KellyAoife KellyClaire KellyNiamh KellySadie KellyYvelynne KellyMaeve KelseyRyan KennedyKalynn KennonSommay KeomanyMaeve KernanYounes KerroumiSharma KeshavEvelyne KestelynImrana KhalidOsama KhalidAntoine KhalilCoralie KhanIrfan KhanQuratul Ain KhanSushil KhanalAbid KhatakAmin KhawajaKrish KherajaniMichelle KhoDenisa KhooRyan KhooSaye KhooNasir KhosoKhor How KiatYuri KidaHarrison KihugaPeter KiizaBeathe Kiland GranerudAnders Benjamin KildalJae Burm KimAntoine KimmounDetlef Kindgen-MillesAlexander KingNobuya KitamuraEyrun Floerecke Kjetland KjetlandPaul KlenermanRob KlontGry Kloumann BekkenStephen KnightRobin KobbeChamira KodippilyMalte Kohns VasconcelosSabin KoiralaMamoru KomatsuVolkan KortenCaroline KosgeiArsène KpangonKarolina KrawczykSudhir KrishnanVinothini KrishnanOksana KruglovaDeepali KumarGanesh KumarMukesh KumarPavan Kumar VechamDinesh KuriakoseEthan KurtzmanNeurinda Permata KusumastutiDemetrios KutsogiannisGalyna KutsynaKonstantinos KyriakoulisErwan L'HerMarie LachatreMarie LacosteJohn LaffeyMarie LagrangeFabrice LaineOlivier LairezSanjay LakheyAntonio LaluezaMarc LambertFrançois LamontagneMarie Langelot-RichardVincent LangloisEka Yudha LantangMarina LanzaCédric LaouénanSamira LaribiDelphine LariviereStéphane LasrySakshi LathNaveed LatifOdile LaunayDidier LaureillardYoan Lavie-BadieAndrew LawAndy LawCassie LawrenceTeresa LawrenceMinh LeClément Le BihanCyril Le BrisGeorges Le FalherLucie Le FevreQuentin Le HingratMarion Le MaréchalSoizic Le MestreGwénaël Le MoalVincent Le MoingHervé Le NagardPaul Le TurnierEma LealMarta Leal SantosBiing Horng LeeHeng Gee LeeJames LeeSu Hwan LeeTodd LeeYi Lin LeeGary LeemingBénédicte LefebvreLaurent LefebvreBenjamin LefevreSylvie LegacJean-Daniel LelievreFrançois LelloucheAdrien LemaignenVéronique LemeeAnthony LemeurGretchen LemminkHa Sha LeneJenny LennonRafael LeónMarc LeoneMichela LeoneQuentin LepillerFrançois-Xavier LescureOlivier LesensMathieu LesouhaitierAmy Lester-GrantAndrew LetiziaBruno LevyYves LevyClaire Levy-MarchalKatarzyna LewandowskaGianluigi Li BassiJanet LiangAli LiaquatGeoffrey LiegeonKah Chuan LimWei Shen LimChantre LimaBruno LinaLim LinaAndreas LindMaja Katherine LingadGuillaume LingasSylvie Lion-DaolioSamantha LissauerKeibun LiuMarine LivrozetPatricia LizotteAntonio LoforteNavy LolongLeong Chee LoonDiogo LopesDalia Lopez-ColonAnthony LoschnerPaul LoubetBouchra LouftiGuillame LouisSilvia LourencoLara Lovelace-MaconLee Lee LowMarije LowikJia Shyi LoyJean Christophe LucetCarlos Lumbreras BermejoCarlos LunaOlguta LunguLiem LuongNestor LuqueDominique LutonNilar LwinRuth LyonsOlavi MaasikasOryane MabialaSarah MacdonaldMoïse MachadoGabriel MachedaJuan Macias SanchezJai MadhokHashmi MadihaGuillermo Maestro de la CalleJacob MagaraGiuseppe MagliettaRafaël MahieuSophie MahyAna Raquel MaiaLars MaierMylène MailletThomas MaitreMaria MajoriMaximilian MalfertheinerNadia MalikPaddy MallonFernando MaltezDenis MalvyPatrizia MammiVictoria MandaJose MandeiLaurent MandelbrotFrank ManettaJulie MankikianEdmund ManningAldric ManuelCeila Maria Sant’ana MalaqueDaniel MarinoFlávio MarinoSamuel MarkowiczCharbel Maroun EidAna MarquesCatherine MarquisBrian MarshLaura MarshMegan MarshalJohn MarshallCelina Turchi MartelliDori-Ann MartinEmily MartinGuillaume Martin-BlondelIgnacio Martin-LoechesAlejandro Martin-QuirosAlessandra MartinelliMartin MartinotAna MartinsJoão MartinsNuno MartinsCaroline Martins RegoGennaro MartucciOlga MartynenkoEva Miranda MarwaliMarsilla MarzukieJuan Fernado Masa JimenezDavid MaslovePhillip MasonSabina MasonSobia MasoodBasri Mat NorMoshe MatanHenrique Mateus FernandesMeghena MathewDaniel MathieuMathieu MatteiRomans MatulevicsLaurence MaulinMichael MaxwellJavier MaynarMayfong MayxayThierry MazzoniNatalie Mc EvoyLisa Mc SweeneyColin McarthurAine MccarthyAnne MccarthyColin MccloskeyRachael McconnochieSherry McdermottSarah McdonaldAine McelroySamuel McelweeVictoria MceneanyAllison McgeerChris MckayJohnny MckeownKenneth McleanPaul McnallyBairbre McnicholasElaine McpartlanEdel MeaneyCécile Mear-PassardMaggie MechlinMaqsood MeherOmar MehkriFerruccio MeleLuis MeloKashif MemonJoao MendesOgechukwu MenkitiKusum MenonFrance MentréAlexander MentzerEmmanuelle MercierNoémie MercierAntoine MerckxMayka Mergeay-FabreBlake MerglerLaura MersonTiziana MeschiAntónio MesquitaRoberta MetaOsama MetwallyAgnès MeybeckDan MeyerAlison MeynertVanina MeysonnierAmina MezianeMehdi MezidiGiuliano MichelagnoliCéline MichelangleiIsabelle MicheletEfstathia MihelisVladislav MihnovitHugo Miranda-MaldonadoNor Arisah MisnanNik Nur Eliza MohamedTahira Jamal MohamedAsma MoinDavid MolinaElena MolinosBrenda MolloyMary MoneAgostinho MonteiroClaudia MontesGiorgia MontrucchioSarah MooreShona MooreLina Morales CelyLucia MoroDiego Rolando Morocho TutilloBen MortonCatherine MotherwayAna MotosHugo MouquetClara Mouton PerrotJulien MoyetCaroline MudaraAisha Kalsoom MuftiNg Yong MuhDzawani MuhamadJimmy MullaertFredrik MüllerKarl Erik MüllerDaniel MunblitSyed MuneebNadeem MunirLaveena MunshiAisling MurphyLorna MurphyMarlène MurrisSrinivas MurthyHimed MusaabCarlotta MuttiHimasha MuvindiGugapriyaa MuyandyDimitra Melia MyrodiaFarah Nadia Mohd-HanafiahDave NagpalMangala NarasimhanNageswaran NarayananRashid Nasim KhanAlasdair Nazerali-MaitlandNadège NeantHolger NebCoca NecsoiNikita NekliudovErni NelwanRaul NetoEmily NeumannBernardo NevesPauline Yeung NgWing Yiu NgAnthony NghiJane NgureDuc NguyenOrna Ni ChoileainNiamh Ni LeathlobhairAlistair NicholPrompak NitayavardhanaStephanie NonasNurul Amani Mohd NoordinMarion NoretNurul Faten Izzati NorharizamLisa NormanAlessandra NotariMahdad NoursadeghiKarolina NowickaAdam NowinskiSaad NseirJose NunezNurnaningsih NurnaningsihDwi Utomo NusantaraElsa NyamankollyAnders Benteson NygaardFionnuala BrienAnnmarie CallaghanAnnmarie O’callaghanMax O’donnellSophie O’halloranKatie O’hearnConar O’neilLinda O’sheaMiriam O’sullivanGiovanna OcchipintiDerbrenn OconnorTawnya OgstonTakayuki OguraTak-Hyuk OhShinichiro OhshimoAgnieszka OldakowskaJoão OliveiraLarissa OliveiraPiero OlliaroDavid OngJee Yan OngWilna OosthuyzenAnne OpavskyPeter OpenshawSaijad OrakzaiClaudia Milena Orozco-ChamorroAndrés OrqueraJamel OrtolevaJavier OsatnikSiti Zubaidah OthmanPaul OtikuNadia OuamaraRachida OuissaClark OwyangEric OziolMaïder PagadoyJustine PagesAmanda PalaciosMario PalaciosMassimo PalmariniGiovanna PanarelloPrasan Kumar PandaHem PaneruLai Hui PangMauro PanigadaNathalie PansuAurélie PapadopoulosPaolo ParducciEdwin Fernando Paredes OñaRachael ParkeMelissa ParkerBriseida ParraVieri ParriniTaha PashaJérémie PasquierBruno PasteneFabian PataunerDrashti PatelMohan Dass PathmanathanLuís PatrãoPatricia PatricioJuliette PatrierLaura PatriziLisa PattersonRajyabardhan PattnaikChristelle PaulMical PaulJorge PaulosWilliam PaxtonJean-François PayenKalaiarasu PeariasamyMiguel Pedrera JiménezGiles PeekFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneMare PejkovskaPaolo PelosiIthan PeltanRui PereiraDaniel PerezLuis PerielThomas PerpointAntonio PesentiVincent PestreLenka PetrouVentzislava Petrov-SanchezMichele PetrovicFrank Olav PettersenGilles PeytavinScott PharandOoyanong PhonemixayMichael PiagnerelliWalter PicardOlivier PiconeMaria de PieroCarola PierobonDjura PiersmaCarlos PimentelRaquel PintoCatarina PiresIsabelle PironneauLionel PirothRoberta PisiAyodhia PitalokaRiinu PiusSimone PivaLaurent PlantierHon Shen PngJulien PoissyRyadh PokeerbuxMaria Pokorska-SpiewakSergio PoliGeorgios PollakisDiane PonscarmeJolanta PopielskaDiego Bastos PortoAndra-Maris PostDouwe PostmaPedro PovoaDiana PóvoasJeff PowisSofia PrapaViladeth PraphasiriSébastien PréauChristian PrebensenJean-Charles PreiserAnton PrinssenMark PritchardGamage Dona Dilanthi PriyadarshaniLucia ProençaSravya PudotaOriane PuéchalBambang Pujo SemediMathew PulickenMatteo PuntoniGregory PurcellLuisa QuesadaVilmaris Quinones-CardonaVíctor Quirós GonzálezElse Quist-PaulsenMohammed QuraishiMaia RabaaChristian RabaudEbenezer RabindrarajanAldo RafaelMarie RafiqGabrielle RagazzoMutia RahardjaniAhmad Kashfi Haji Ab RahmanRozanah Abd RahmanArsalan RahutullahFernando RainieriGiri Shan RajahramPratheema RamachandranNagarajan RamakrishnanKollengode RamanathanAhmad Afiq RamliBlandine RammaertGrazielle Viana RamosAnais RampelloAsim RanaRajavardhan RangappaRitika RanjanElena RanzaChristophe RappAasiyah RashanThalha RashanGhulam RasheedMenaldi RasminIndrek RätsepCornelius RauFrancesco RausaTharmini RaviAli RazaAndre RealStanislas RebaudetSarah RedlBrenda ReeveAttaur RehmanLiadain ReidDag Henrik ReikvamRenato ReisJordi RelloJonathan RemppisMartine RemyHongru RenHanna RenkAnne-Sophie ResseguierMatthieu RevestOleksa RewaLuis Felipe ReyesTiago ReyesMaria Ines RibeiroAntonia RicchiutoDavid RichardsonDenise RichardsonLaurent RichierSiti Nurul Atikah Ahmad RidzuanJordi RieraAna RiosAsgar RishuPatrick RispalKarine RissoMaria Angelica Rivera NuñezNicholas RizerChiara RobbaAndré RobertoStephanie RobertsDavid RobertsonOlivier RobineauFerran Roche-CampoPaola RodariSimão RodeiaJulia Rodriguez AbreuBernhard RoesslerClaire RogerPierre-Marie RogerEmmanuel RoilidesAmanda RojekJuliette RomaruRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerNurul Hidayah Mohammad RoslanAndrea RossaneseMatteo RossettiSandra RossiBénédicte RossignolPatrick RossignolStella RoussetCarine RoyBenoît RozeDesy RusmawatiningtyasClark RussellMaeve RyanMaria RyanMazankowski Heart Institute RyckaertSteffi RyckaertAleksander Rygh HoltenIsabela SabaLuca SacchelliSairah SadafMusharaf SadatValla SahraeiNadia SaidaniMaximilien Saint-GillesPranya SakiyalakNawal SalahuddinLeonardo SalazarJodat SaleemNazal SalehGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorOlivier SanchezXavier Sánchez ChoezKizy Sanchez de OliveiraAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineOana SandulescuMarlene SantosShirley Sarfo-MensahBruno Sarmento BanheiroIam Claire E. SarmientoBenjamine SartonAnkana SatyaSree SatyapriyaRumaisah SatyawatiEgle SaviciuteParthena SavvidouYen Tsen SawJustin SchafferTjard SchermerArnaud ScherpereelMarion SchneiderStephan SchrollMichael SchwameisGary SchwartzJanet ScottJames Scott-BrownNicholas SedillotTamara SeitzJaganathan SelvanayagamMageswari SelvarajooCaroline SemailleMalcolm SempleRasidah Bt SenianEric SennevilleClaudia SepulvedaFilipa SequeiraTânia SequeiraAry Serpa NetoPablo Serrano BalazoteEllen ShadowitzSyamin Asyraf ShahidanMohammad ShamsahAnuraj ShankarShaikh SharjeelPratima SharmaCatherine ShawVictoria ShawAshraf SheharyarDr. Rajesh Mohan ShettyRohan ShettyHaixia ShiNisreen ShibanMohiuddin ShiekhTakuya ShigaNobuaki ShimeHiroaki ShimizuKeiki ShimizuNaoki ShimizuSally ShrapnelPramesh Sundar ShresthaShubha Kalyan ShresthaHoi Ping ShumNassima Si MohammedNg Yong SiangJeanne SibiudeBountoy SibounheuangAtif SiddiquiLouise SigfridPiret SillaotsCatarina SilvaMaria Joao SilvaRogério SilvaBenedict Sim Lim HengWai Ching SinDario SinattiBudha Charan SinghPunam SinghPompini Agustina SitompulKarisha SivamVegard SkogenSue SmithBenjamin SmoodCoilin SmythMichelle SmythMorgane SnackenDominic SoTze Vee SohLene Bergendal SolbergJoshua SolomonTom SolomonEmily SomersAgnès SommetMyung Jin SongRima SongTae SongJack Song ChiaMichael SonntagbauerAzlan Mat SoomArne SøraasCamilla Lund SøraasAlberto SottoEdouard SoumAna Chora SousaMarta SousaMaria Sousa UvaVicente Souza-DantasAlexandra SperryElisabetta SpinuzzaB. DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherTrude SteinsvikYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelSamantha StrudwickAmi StuartDavid StuartDecy SubektiGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicDeepashankari SuppiahMagdalena SurovcováSuwarti SuwartiAndrey SvistunovSarah SyahrinKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziFabio TacconeLysa TaghersetShahdattul Mawarni TaibEwa TalarekSara TalebJelmer TalsmaRenaud TamisierMaria Lawrensia TampubolonKim Keat TanLe Van TanYan Chyi TanClarice TanakaHiroyuki TanakaTaku TanakaHayato TaniguchiHuda TaqdeesArshad TaqiCoralie TardivonPierre TattevinM Azhari TaufikHassan TawfikRichard TedderTze Yuan TeeJoão TeixeiraSofia TejadaMarie-Capucine TellierSze Kye TeohVanessa TeotonioFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAlif Adlan Mohd ThabitAnand ThakurZhang Duan ThamSuvintheran ThangaveluV. ThibaultSimon-Djamel ThibervilleBenoît ThillJananee ThirumanickamShaun ThompsonDavid ThomsonEmma ThomsonSurain Raaj Thanga ThuraiDuong Bich ThuyRyan ThwaitesAndrea TicinesiPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitBharath Kumar Tirupakuzhi VijayaraghavanNoémie TissotJordan Zhien Yang TohMaria TokiKristian TonbySia Loong TonniiAntoni TorresMargarida TorresRosario Maria Torres Santos-OlmoHernando Torres-ZevallosMichael TowersTony TrapaniThéo TreouxHuynh Trung TrieuCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteJean-Marie TurmelLance TurtleAnders TveitaPawel TwardowskiMakoto UchiyamaP UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresPiero ValentiniAna Luiza ValleAmélie ValranIlaria ValzanoStijn van de VeldeMarcel van den BergeMachteld van der FeltzJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van Der WerfMarlice van DykLaura van GulikJarne van HattemCarolien van NettenGitte van TwillertIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseMichael VarroneShoban Raj VasudayanCharline VauchyShaminee VeeranAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoNguyen van Vinh ChauGayatri VishwanathanBenoit VisseauxHannah VisserChiara VitielloManivanh VongsouvathHarald VonkemanFanny VuottoNoor Hidayu WahabSuhaila Abdul WahabNadirah Abdul WahidMarina WainsteinWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbJia WeiKatharina WeilTan Pei WenSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsEvert-Jan WilsCalvin WongTeck Fung WongXin Ci WongYew Sing WongNatalie WrightGan Ee XianLim Saio XianKuan Pei XuanIoannis XynogalasSophie YacoubSiti Rohani Binti Mohd YakopMasaki YamazakiYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichTouxiong YiayeToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeKai ZacharowskiMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaKonrad ZawadkaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid ZucmanEsteban Garcia-GalloLaura MersonKalynn KennonSadie KellyBarbara Wanjiru CitarellaDaniel Vidali FryerSally ShrapnelJames LeeSara DuqueYuli FuentesValeria BalanSue SmithJia WeiBronner GonçalvesClark RussellLouise SigfridAndrew DagensPiero OlliaroJoaquin BaruchChristiana KartsonakiJake DunningAmanda RojekAasiyah RashanAbi BeaneSrinivas MurthyLuis Felipe Reyes
• Organismes : Imagine - Institut des maladies génétiques (IHU) Centre Hospitalier Universitaire de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Service Maladies infectieuses et tropicales [CHU Toulouse] Service Pneumologie-Allergologie [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Pôle Clinique des Voies respiratoires [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Service Maladies infectieuses et tropicales [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] Universidad de La Sabana [Chía, Cundinamarca, Colombia] = La Sabana University [Chía, Cundinamarca, Colombia] The University of Queensland University of British Columbia [Canada] Universidad de La Sabana [Chía, Cundinamarca, Colombia] = La Sabana University [Chía, Cundinamarca, Colombia] University of Oxford
• Publié dans Scientific Data le 29/10/2020

---

Résumé : The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.

---

Fichiers liés : s41597-022-01534-9.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Catherine SchrammCamille CharbonnierAline ZaréaMorgane LacourDavid WallonDaniela AndriutaPierre AnthonySophie AuriacombeAnna-Chloé BalageasGuillaume BallanMélanie BarbayEmilie BeaufilsYannick BéjotSerge BelliardMarie BenaiteauKarim BennysFrédéric BlancStéphanie BomboisClaire Boutoleau-BretonnièrePierre BrangerJasmine CarlierLeslie Cartz-PiverPascaline CassagnaudGiovanni CastelnovoChristine ChampionAnnabelle ChaussenotMathieu CeccaldiValérie ChauviréYaohua ChenJulien CogezEmmanuel CognatFabienne Contegal-CallierLea CorneillePhilippe CouratierHélène CourtemancheBenjamin CretinCharlotte CrinquetteBernard CroisilleBenjamin DauriatSophie DautricourtVincent de la SayetteAstrid de LiègeMarie de VerdalDidier DeffondEmmanuelle GéninBenoit DelpontFlorence DemurgerVincent DeramecourtCéline DerollezMira DidicGiulia DiemertElsa DionetPhilippe DiraisonAude DoanMartine Doco-FenzyBoris DufournetJulien DumurgierHélène DurandAnaïs DutrayFrédérique Etcharry-BouyxMaïté FormaglioAudrey GabelleAnne Gainche-SalmonJean-Claude GetenetEmmanuelle GinglingerOlivier GodefroyMathilde GraberChloé GregoireStephan GrimaldiJulien GueniatClaude GueriotSophie HaffenLorraine HamelinDidier HannequinCezara HantaClémence HardyGeoffroy HautecloqueCamille HeitzClaire HourregueThérèse JonveauxSnejana JuriciCatia KhoumriLejla KoricPierre Krolak-SalmonPierre LabaugeMorgane LacourJulien LagardeHélène-Marie LanoiseléeBrice LaurensIsabelle Le BerGwenaël Le GuyaderAmélie LeblancThibaud LebouvierAnaïs LippiMarie-Anne MackowiakEloi MagninCecilia MarelliOlivier MartinaudAurélien MaureilleEmilie Milongo-RigalSophie MohrHélène MollionOlivier MoreaudAlexandre MorinGaël NicolasJulia NivelleCamille NoirayElisabeth Ollagnon-RomanClaire PaquetJérémie ParienteFlorence PasquierAlexandre PerronNathalie PhilippiVirginie PichonVincent PlancheCéline PoirsierMarie RafiqPauline Rod-OlivieriAdeline Rollin-SillaireCarole Roué-JagotDario SaracinoMarie SarazinMathilde SauvéeFrançois SellalLila Sirven VillarosChristel Thauvin-RobinetCamille TisserandChristophe TomasinoCédric TurpinatLaurène van DammeOlivier VercruysseAlice VoillyNathalie WagemannDavid WallonAline ZareaAnne BolandJean-François DeleuzeRobert OlasoShahzad AhmadPhilippe AmouyelClaudine BerrAnne BolandPaola BossuFemke BouwmanJose BrasDominique CampionCamille CharbonnierJordi ClarimonAntonio DanieleJean-François DartiguesStéphanie DebetteJean-François DeleuzeNicola DenningOriol Dols-IcardoNick FoxDaniela GalimbertiHans GilleBenjamin Grenier-BoleyDetelina GrozevaRita GuerreiroJohn HardyClive HolmesHenne HolstegeMarc HulsmanHolger HummerichM. Arfan IkramM. Kamran IkramIris JansenAmit KawaliaRobert KraaijJean-Charles LambertMarc LathropAfina LemstraAlberto LleoLauren LuckcuckMarcel MannensRachel MarshallCarlo MasulloSimon MeadPatrizia MecocciAlun MeggyMerel MolKevin MorganBenedetta NacmiasGaël NicolasPenny NorsworthyFlorence PasquierPau PastorOlivier QuenezAlfredo RamirezRachel RaybouldRichard RedonMarcel ReindersAnne-Claire RichardSteffi Riedel-HellerFernando RivadeneiraStéphane RousseauNatalie RyanSalha SaadPascual Sanchez-JuanPhilip ScheltensJonathan SchottDavide SeripaDaoud SieRebecca SimsErik SistermansSandro SorbiResie van SpaendonkGianfranco SpalletaNicćolo TesiBetty TijmsAndré UitterlindenWiesje van der FlierSven van der LeeCornelia van DuijnJeroen van RooijJohn van SwietenPieter de VisserMichael WagnerDavid WallonJulie WilliamsAline ZareaFlora AlarconDominique CampionG. NuelGaël Nicolas
• Organismes : Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques CHU Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Service de neurologie [Rouen] UNIROUEN - UFR Santé Service de neurologie [Rouen] CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Centre national de référence pour les malades Alzheimer jeunes Institut des Maladies Neurodégénératives [Bordeaux] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier de la Côte Basque CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Centre national de référence pour les malades Alzheimer jeunes Centre Hospitalier Régional Universitaire de Tours Université de Bourgogne Université Lille Nord (France) AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité Santé publique France - French National Public Health Agency [Saint-Maurice, France] Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique Université Paris Descartes, Sorbonne Paris Cité Service de Neurologie [CHU Rennes] Département Neurologie [CHU Toulouse] Département de neurologie [Montpellier] Centre Hospitalier Universitaire [Strasbourg] Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Centre Mémoire Ressources et Recherche [Strasbourg] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Côte de Nacre [CHU Caen] UNIROUEN - UFR Santé Epidémiologie des Maladies Chroniques en zone tropicale Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Centre national de référence pour les malades Alzheimer jeunes Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Mathématiques Appliquées Paris 5
• Publié dans Genome Medicine le 24/10/2020

---

Résumé : Abstract Background Alzheimer disease (AD) is a common complex disorder with a high genetic component. Loss-of-function (LoF) SORL1 variants are one of the strongest AD genetic risk factors. Estimating their age-related penetrance is essential before putative use for genetic counseling or preventive trials. However, relative rarity and co-occurrence with the main AD risk factor, APOE -ε4, make such estimations difficult. Methods We proposed to estimate the age-related penetrance of SORL1 -LoF variants through a survival framework by estimating the conditional instantaneous risk combining (i) a baseline for non-carriers of SORL1- LoF variants, stratified by APOE-ε4 , derived from the Rotterdam study ( N = 12,255), and (ii) an age-dependent proportional hazard effect for SORL1- LoF variants estimated from 27 extended pedigrees (including 307 relatives ≥ 40 years old, 45 of them having genotyping information) recruited from the French reference center for young Alzheimer patients. We embedded this model into an expectation-maximization algorithm to accommodate for missing genotypes. To correct for ascertainment bias, proband phenotypes were omitted. Then, we assessed if our penetrance curves were concordant with age distributions of APOE -ε4-stratified SORL1- LoF variant carriers detected among sequencing data of 13,007 cases and 10,182 controls from European and American case-control study consortia. Results SORL1- LoF variants penetrance curves reached 100% (95% confidence interval [99–100%]) by age 70 among APOE -ε4ε4 carriers only, compared with 56% [40–72%] and 37% [26–51%] in ε4 heterozygous carriers and ε4 non-carriers, respectively. These estimates were fully consistent with observed age distributions of SORL1- LoF variant carriers in case-control study data. Conclusions We conclude that SORL1- LoF variants should be interpreted in light of APOE genotypes for future clinical applications.

---

Fichiers liés : Article-Schramm-Genome-Medicine-2022.pdf

---

Source

---

• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 30/11/2022
• Auteurs : Philippe DufieuxPierre Gras
• Organismes : EVS-LAURe EVS-LAURe

---

Résumé : L'histoire d'un quartier singulier, emblème de la modernité lyonnaise. Le quartier de la Duchère a connu une métamorphose spectaculaire à la fin des années 1950 par la construction de l'un des grands ensembles les plus emblématiques de la cité rhodanienne. Cette vaste opération urbaine de plus de cinq mille logements, conçue sous la direction des architectes François-Régis Cottin et Franck Grimal, s'impose comme l'un des champs d'expérimentation privilégiés de l'urbanisme et de l'architecture contemporains. Elle s'organise autour de quatre secteurs : la Sauvegarde, le Plateau, le Château et Balmont. Après une phase de déclin, les pouvoirs publics se sont employés, à l'aube du troisième millénaire, à transformer durablement la Duchère pour lui forger un nouvel avenir autour d'un grand projet de ville qui a mobilisé, aux côtés des habitants, une multitude d'acteurs. Ces vingt dernières années, un nouveau quartier à échelle humaine a vu le jour sous l'égide de l'architecte Bernard Paris et du paysagiste Alain Marguerit qui ont repensé à la fois les formes urbaines et les aménagements publics, écrivant ainsi une nouvelle page de son développement. Cet ouvrage rend compte de cette histoire singulière en s'appuyant sur des sources inédites et la mémoire de nombreux acteurs de la métamorphose de la troisième colline de Lyon.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 29/11/2022
• Auteurs : Michael PaillasseMichael EsquerréFlorie BertrandCéline Poussereau-PomiéMélanie PicheryVirgile VisentinGeneviève Gueguen-DorbesFlorence GaujarenguesPauline BarronGaelle BadetAnne BriauxPierre-Benoit AnceyDavid SibracEric ErdociainDennis ÖzcelikJérôme MeneyrolValérie MartinAnne Gomez-BrouchetJanik SelvesPhilippe RochaixMaxime BattistellaCéleste LebbéJean-Pierre DelordFrédérique Dol-GleizesFrançoise BonoIsabelle BlancAntoine AlamIan HunneyballMark WhittakerPierre Fons
• Organismes : Centre Hospitalier Universitaire de Toulouse
• Publié dans Cancer Research Communications le 17/05/2023

---

Résumé : The receptor tyrosine kinase VEGFR-3 plays a crucial role in cancer-induced angiogenesis and lymphangiogenesis, promoting tumor development and metastasis. Here, we report the novel VEGFR-3 inhibitor EVT801 that presents a more selective and less toxic profile than two major inhibitors of VEGFRs (i.e., sorafenib and pazopanib). As monotherapy, EVT801 showed a potent antitumor effect in VEGFR-3–positive tumors, and in tumors with VEGFR-3–positive microenvironments. EVT801 suppressed VEGF-C–induced human endothelial cell proliferation in vitro and tumor (lymph)angiogenesis in different tumor mouse models. In addition to reduced tumor growth, EVT801 decreased tumor hypoxia, favored sustained tumor blood vessel homogenization (i.e., leaving fewer and overall larger vessels), and reduced important immunosuppressive cytokines (CCL4, CCL5) and myeloid-derived suppressor cells (MDSC) in circulation. Furthermore, in carcinoma mouse models, the combination of EVT801 with immune checkpoint therapy (ICT) yielded superior outcomes to either single treatment. Moreover, tumor growth inhibition was inversely correlated with levels of CCL4, CCL5, and MDSCs after treatment with EVT801, either alone or combined with ICT. Taken together, EVT801 represents a promising anti(lymph)angiogenic drug for improving ICT response rates in patients with VEGFR-3 positive tumors. Significance: The VEGFR-3 inhibitor EVT801 demonstrates superior selectivity and toxicity profile than other VEGFR-3 tyrosine kinase inhibitors. EVT801 showed potent antitumor effects in VEGFR-3–positive tumors, and tumors with VEGFR-3–positive microenvironments through blood vessel homogenization, and reduction of tumor hypoxia and limited immunosuppression. EVT801 increases immune checkpoint inhibitors’ antitumor effects.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 29/11/2022
• Auteurs : Elise LaruelleKatia BelcramAlain TrubuilJean-Christophe PalauquiPhilippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] Institut Jean-Pierre Bourgin - Sciences du végétal Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans eLife le 23/10/2020

---

Résumé : Noise plays a major role in cellular processes and in the development of tissues and organs. Several studies have examined the origin, the integration or the accommodation of noise in gene expression, cell growth and elaboration of organ shape. By contrast, much less is known about variability in cell division plane positioning, its origin and links with cell geometry, and its impact on tissue organization. Taking advantage of the first-stereotyped-then-variable division patterns in the embryo of the model plant Arabidopsis thaliana , we combined 3D imaging and quantitative cell shape and cell lineage analysis together with mathematical and computer modeling to perform a large-scale, systematic analysis of variability in division plane orientation. Our results reveal that, paradoxically, variability in cell division patterns of Arabidopsis embryos is accompanied by a progressive reduction of heterogeneity in cell shape topology. The paradox is solved by showing that variability operates within a reduced repertoire of possible division plane orientations that is related to cell geometry. We show that in several domains of the embryo, a recently proposed geometrical division rule recapitulates observed variable patterns, suggesting that variable patterns emerge from deterministic principles operating in a variable geometrical context. Our work highlights the importance of emerging patterns in the plant embryo under iterated division principles, but also reveal domains where deviations between rule predictions and experimental observations point to additional regulatory mechanisms.

---

Fichiers liés : 2022.03.23.483962.full.pdf

---

Source

---

• Type de publi. :
• Date de publi. : 28/11/2022
• Auteurs : Eric BiotSandrine LefrancAyoub OuddahPhilippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

---

Résumé : Biological imaging is one of the major tools used to decipher the functioning of meristems in plant morphogenesis. Extracting quantitative information from microscopy images typically requires complex image processing and analysis pipelines, designed by combining elementary operations such as signal enhancement, object segmentation, and object measurements. Moreover, integrating data through the processing of large image datasets is required to model variability and ensure robust analyses. Existing image analysis software solutions fall into two categories that come with their respective limitations. On the one hand, dedicated libraries such as ITK provide collections of basic components that can be assembled into possibly complex image processing pipelines. This requires a strong computer programming expertise. On the other hand, embedded software such as Fiji provide user-friendly graphical interfaces that allow end users with little or no programming expertise to perform a wide range of predefined image processing operations. The possibilities for automation and batch processing are however often limited, and generally do not eliminate the need for the user to do some programming. We address these limitations by proposing a new software, called BIP, for batch processing and analysis of biological images. BIP integrates many standard algorithms and specific algorithms developed in the framework of our research projects for quantifying images of plant cells and tissues. BIP fills-in an empty niche in the ecosystem of bioimaging software, by relying on a simple yet powerful command line interface. Furthermore, integrating BIP within frameworks for high-throughput, distributed computing is straightforward. BIP allows users to easily specify sets of images to be processed and to readily chain basic operations into complex analysis pipelines. BIP offers transparent support for images of arbitrary dimensions (2D to 5D) and numerical types (integer and floating numbers, signed and unsigned, from 8 to 32 bits), thus breaking the compatibility barriers often encountered between implementations of different algorithms in existing software. This performance is achieved thanks to a single, unified templated data structure to represent multi-dimensional images and a generic design pattern for the automatic detection of the numerical data type in input images. In addition, these design principles allow minimizing the number of implementations of each algorithm, thus easying code maintenance, evolution, and optimization. Here, we illustrate through several examples the benefits and potential of BIP for processing and quantifying image datasets of plant cells and tissues, including 3D time-lapse confocal images of A. thaliana shoot apical meristems.

---

Source