Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/07/2022
• Auteurs : Jean-Philip BrugalGuy AndréJean-Baptiste FourvelPhilippe FosseMarina IgrejaPierre MagniezLéo PascalA. Uzunidis
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Institut Català de Paleoecologia Humana i Evolució Social

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• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2022
• Auteurs : Friedrich WalzelAlice RequierKevin BoschiJean FaragoPhilippe FuchsFabrice ThalmannWiebke Drenckhan-AndreattaPierre MullerThierry Charitat
• Organismes : Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron Institut Charles Sadron
• Publié dans Physical Review E le 21/10/2020

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Résumé : Minimal surface problems arise naturally in many soft matter systems whose free energies are dominated by surface or interface energies. Of particular interest are the shapes, stability and mechanical stresses of minimal surfaces spanning specific geometric boundaries. The "catenoid" is the best-known example where an analytical solution is known which describes the form and stability of a minimal surface held between two parallel, concentric circular frames. Here we extend this problem to non-axisymmetric, parallel frame shapes of different orientations, by developing a perturbation approach around the known catenoid solution. We show that the predictions of the perturbation theory are in good agreement with experiments on soap films and finite element simulations (Surface Evolver). Combining theory, experiment and simulation, we analyse in depth how the shapes, stability and mechanical properties of the minimal surfaces depend on the type and orientation of elliptical and three-leaf clover shaped frames. In the limit of perfectly aligned non-axisymmetric frames, our predictions show excellent agreement with a recent theory established by Alimov et al (M. M. Alimov, A. V. Bazilevsky and K. G. Kornev, Physics of Fluids, 2021, 33, 052104). Moreover, we put in evidence the intriguing capacity of minimal surfaces between non-axisymmetric frames to transmit a mechanical torque despite being completely liquid. These forces could be interesting to exploit for mechanical self-assembly of soft matter systems or as highly sensitive force captors.

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Fichiers liés : 2203.16140.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2022
• Auteurs : Shengli TaoJérôme ChavePierre-Louis FrisonThuy Le ToanPhilippe CiaisJingyun FangWigneron J.-P.Maurizio SantoroHui YangXiaojun LiNicolas LabrièreSassan Saatchi
• Organismes : Evolution et Diversité Biologique Peking University [Beijing] Evolution et Diversité Biologique Laboratoire en Sciences et Technologies de l'Information Géographique Centre d'études spatiales de la biosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Peking University [Beijing] Interactions Sol Plante Atmosphère Gamma Remote Sensing Research and Consulting AG Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Evolution et Diversité Biologique Jet Propulsion Laboratory
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : Intact tropical rainforests have been exposed to severe droughts in recent decades, which may threaten their integrity, their ability to sequester carbon, and their capacity to provide shelter for biodiversity. However, their response to droughts remains uncertain due to limited high-quality, long-term observations covering extensive areas. Here, we examined how the upper canopy of intact tropical rainforests has responded to drought events globally and during the past 3 decades. By developing a long pantropical time series (1992 to 2018) of monthly radar satellite observations, we show that repeated droughts caused a sustained decline in radar signal in 93%, 84%, and 88% of intact tropical rainforests in the Americas, Africa, and Asia, respectively. Sudden decreases in radar signal were detected around the 1997–1998, 2005, 2010, and 2015 droughts in tropical Americas; 1999–2000, 2004–2005, 2010–2011, and 2015 droughts in tropical Africa; and 1997–1998, 2006, and 2015 droughts in tropical Asia. Rainforests showed similar low resistance (the ability to maintain predrought condition when drought occurs) to severe droughts across continents, but American rainforests consistently showed the lowest resilience (the ability to return to predrought condition after the drought event). Moreover, while the resistance of intact tropical rainforests to drought is decreasing, albeit weakly in tropical Africa and Asia, forest resilience has not increased significantly. Our results therefore suggest the capacity of intact rainforests to withstand future droughts is limited. This has negative implications for climate change mitigation through forest-based climate solutions and the associated pledges made by countries under the Paris Agreement.

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Fichiers liés : pnas.2116626119.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/07/2022
• Auteurs : Niranjan ThatteDave MelotteBenoit NeichelDavid Le MignantIan BrysonArthur ViganFraser ClarkeVanessa Ferraro-WoodThierry FuscoOscar GonzalezHermine SchnetlerMatthias TeczaSandi WilsonAlonso Álvarez UrueñaHeribert VilasecaSantiago Arribas MocoroaGonzalo José Carracedo CarballaleAlejandro CrespoAlberto Estrada PiquerasMiriam García GarcíaCecilia Martínez MartínMiguel Pereira SantaellaMichele PernaJavier Piqueras LópezNicolas F. BouchéDidier BoudonEric DaguiséKaren DisseauJérémy FenschAdrien GirardotMatthieu GuibertAurélien JarnoAlexandre JeanneauJens-Kristian KrogagerFlorence LaurentMagali LoupiasJean-Emmanuel MigniauLaure PiquerasAlban RemillieuxJohan P RichardArlette Pécontal-RoussetLisa BardouDavid BarrSylvain CetreRishi DeshmukhSofia DimoudiMarc DubbledamAndrew DunnDimitra GadottiJoss GuyDavid KingDavid LittleAnna McleodSimon MorrisTim MorrisKieran O'BrienEmily RonsonRussell SmithLazar StaykovMark SwinbankMatthew TownsonMatteo AccardoDomingo Alvarez MendezElizabeth GeorgeJoshua HopgoodDerek IvesLeander MehrganEric MuellerJavier Reyes-MorenoRalf ConzelmannPablo Gutierrez CheethamÁngel Alonso-SánchezGiuseppina BattagliaMiguel Angel Cagigas GarciaHaresh ChulaniGraciela Delgado GarcíaPatricia Fernández-IzquierdoAna Belén Fragoso LópezBegoña García-LorenzoAlberto Hernández GonzálezElvio Hernández SuárezJose Miguel Herreros LinaresEnrique JovenRoberto López LópezAlejandro Antonio Lujan GonzalezYolanda MartínEvencio MediavillaSaúl Menéndez MendozaLuz Maria Montoya MartínezJosé Peñate CastroÁlvaro PérezJosé Luis RasillaRafael Rebolo-LópezLuis Fernando Rodríguez-RamosAfrodisio Vega MorenoTeodora Viera-CurbeloNatacha Zanon DamettoAlexis CarlottiJean-Jacques CorreiaStéphane CurabaAlain DelboulbéSylvain GuieuAdrien HoursZoltan HubertLaurent JocouYves MagnardThibaut MoulinFabrice PancherPatrick RabouEric StadlerMaxime VéroveT. ContiniMarie LarrieuOlivier BoebionYan Fantéï-CaujolleDaniel LecronSylvain RousseauPhilippe AmramOlivier Beltramo-MartinWilliam BonAnne BonnefoiWilliam CeriaZalpha ChallitaYannick CharlesElodie ChoquetCarlos CorreiaAnne CostilleKjetil DohlenFranck DucretKacem El HadiJean-Luc GachJean-Luc GimenezOlivier GroussinMarc JaquetPierre JouveFabrice MadecFelipe Pedreros BustosEdgard RenaultPatrice SanchezPascal VolaAnnie ZavagnoRomain FétickC B LimCyril PetitJ.-F. SauvageNicolas VédrenneFehim Taha BagciMartin CaldwellEllis ElliottPeter HiscockEmma JohnsonMurali NalagatlaAristea SeitisMark WellsMartin BlackCharlotte BondSaskia BrierleyKenneth CampbellNeil CampbellJames CarruthersWilliam CochraneChris EvansJoel HarmanWilliam HumphreysThomas LouthChris MillerDavid MontgomeryMeenu MuraliJohn MurrayNorman O'MalleyRuben Sanchez-JanssenNoah SchwartzPatrick SmithJonathan StrachanStephen ToddStuart WattMartyn WellsAsim YaqoobEric BellOleg GnedinKayhan GultekinMario MateoMichael MeyerMunadi AhmadJayne BirkbyMichael BoothMichele CappellariEdgar Castillo DominguezJorge Chao OrtizDavid GoodingKearn GrisdaleAndrea Hidalgo ValadezLaurence HoganJames KariukiIan LewisAdam LoweZeynep OzerLaurence RoutledgeDimitra RigopoulouAlec York
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille DOTA, ONERA, Université Paris Saclay [Palaiseau] Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Centre de Recherche Astrophysique de Lyon Institut de recherche en astrophysique et planétologie Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Institut universitaire de France DOTA, ONERA, Université Paris Saclay [Châtillon] DOTA, ONERA [Salon-de-Provence] DOTA, ONERA, Université Paris Saclay [Châtillon]

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Résumé : HARMONI is the first light, adaptive optics assisted, integral field spectrograph for the European Southern Observatory’s Extremely Large Telescope (ELT). A work-horse instrument, it provides the ELT’s diffraction limited spectroscopic capability across the near-infrared wavelength range. HARMONI will exploit the ELT’s unique combination of exquisite spatial resolution and enormous collecting area, enabling transformational science. The design of the instrument is being finalized, and the plans for assembly, integration and testing are being detailed. We present an overview of the instrument’s capabilities from a user perspective, and provide a summary of the instrument’s design. We also include recent changes to the project, both technical and programmatic, that have resulted from red-flag actions. Finally, we outline some of the simulated HARMONI observations currently being analyzed.

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Fichiers liés : 1218420.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/07/2022
• Auteurs : Pierre DrossartPanek EmilieVirginie BatistaJean-Philippe BeaulieuJean-Pierre Maillard
• Organismes : Institut d'Astrophysique de Paris

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2022
• Auteurs : Seda SerenJean-Patrick JolyPierre VoisinVéronique BouchaudGérard AudranSylvain R A MarquePhilippe Mellet
• Organismes : Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques
• Publié dans Journal of Medicinal Chemistry le 25/10/2020

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Résumé : Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil elastase activity in cancer is associated with poor prognosis and metastasis settlement. More generally, tumors harbor various and persistent protease activities unseen in healthy tissues. In an attempt to be more specific, we designed prodrugs that are activatable by neutrophil elastase. Upon activation, these alkoxyamine-based drugs release cytotoxic alkyl radicals that act randomly to prevent drug resistance. As a result, U87 glioblastoma cells displayed high level caspase 3/7 activation during the first hour of exposure in the presence of human neutrophil elastase and the prodrug in vitro. The apoptosis process and cell death occurred between 24 and 48 h after exposure with a half lethal concentration of 150 μM. These prodrugs are versatile and easy to synthetize and can be adapted to many enzymes.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/07/2022
• Auteurs : Jean-Philippe MaguéLouise TarradeJean-Pierre ChevrotMélanie Veloso
• Organismes : Institut Rhône-Alpin des systèmes complexes Interactions, Corpus, Apprentissages, Représentations LInguistique et DIdactique des Langues Étrangères et Maternelles Institut Rhône-Alpin des systèmes complexes LInguistique et DIdactique des Langues Étrangères et Maternelles

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• Type de publi. : Article dans une revue
• Date de publi. : 13/07/2022
• Auteurs : Alexandre MansourErwan FlecherMatthieu SchmidtBertrand RozecIsabelle Gouin-ThibaultMaxime EsvanClaire FougerouBruno LevyAlizée PortoJames RossMarylou ParaSabrina ManganielloGuillaume LebretonAndré VincentelliNicolas NesselerMarc PierrotSidney ChocronGuillaume FlicoteauxPhilippe MauriatAlexandre OuattaraHadrien RozeOlivier HuetMarc-Olivier FischerClaire AlessandriRaphel BellaïcheOphélie ConstantQuentin de RouxAndré LyArnaud MeffertJean-Claude MerleNicolas MongardonLucile PicardElena SkripkinaThierry FolliguetAntonio FioreNicolas D’ostrevyMarie-Catherine MorganPierre-Grégoire GuinotMaxime NguyenLucie Gaide-ChevronnayNicolas TerziGwenhaël ColinOlivier FabreArash AstanehJustin IssardElie FadelDominique FabreAntoine GiraultJulien GuihaireIolande IonJean Baptiste MenagerDelphine MitilianOlaf MercierFrançois StephanJacques ThesJerôme JouanThibault DuburcqValentin LoobuyckMouhammed MoussaAgnes MugnierNatacha RousseOlivier DesebbeJean-Luc FellahiRoland HenaineMatteo PozziJean-Christophe RichardZakaria RiadChristophe GuervillyMuriel FartoukhLaurent PapazianMatthias CastanierCharles ChanavazCyril CadozSebastien GetteGuillaume LouisErick PortocarreroPhilippe GaudardKais BriniNicolas BischoffAntoine KimmounMathieu MatteiPierre PerezAlexandre BourdiolYannick HourmantPierre-Joachim MahéPierre JaquetBrice Lortat-JacobPierre MordantPatrick NatafJuliette PatrierSophie ProvenchèreMorgan RouéRomain SonnevilleAlexy Tran-DinhPaul-Henri WickyCharles Al ZreibiBernard CholleyYannis GuyonvarchSophie HamadaAnatole HarroisJordi MatielloT KerforneCorentin LacroixNicolas BrechotAlain CombesJuliette ChommelouxJean Michel ConstantinCosimo D’alessandroPierre DemondionAlexandre DemouleMartin DresGuillaume FadelMuriel FartoukhGuillaume HekimianCharles JuvinPascal LeprinceDavid LevyCharles Edouard LuytMarc Pineton de ChambrunThibaut SchoellPierre FillâtreNicolas MassartRoxane NicolasMaud JonasCharles VidalNicolas AllouSalvatore MuccioDario Di PernaVito-Giovanni RuggieriBruno MourvillierAmedeo AnselmiKarl BounaderYoann LauneyThomas LebouvierAlessandro ParasidoFlorian ReizinePhilippe SeguinEmmanuel BesnierDorothée CarpentierThomas ClavierPierre-Emmanuel FalcozAnne OllandMarion VillardFanny BounesFrançois LabasteVincent MinvilleAntoine GuillonYannick Fedun
• Organismes : Service de Réanimation Médicale [CHRU Nancy]
• Publié dans Intensive Care Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 12/07/2022
• Auteurs : Grace FrancoisPierre CleuziouQuentin Vannod-MichelPhilippe DerambureSylvie Nguyen The TichLaurence Chaton
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Neuropediatrics le 14/06/2017

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Résumé : Introduction Various neurologic manifestations have already been described in children during or after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The central nervous system disorders reported in children are mainly encephalopathies during multisystem inflammatory syndrome. We present here an acute meningoencephalitis with cerebral vasculitis associated to a coronavirus disease 2019 (COVID-19) infection in a 13-year-old girl with a 1-year clinical, electroencephalogram (EEG), and magnetic resonance imaging (MRI) follow-up. Case Report A 13-year-old girl presented acute symptoms of consciousness impairment, frontal headache, hyperthermia, and aphasia, with moderate lymphopenia (900/mm3), elevated C-reactive protein (17 mg/L), cerebrospinal fluid (CSF) pleocytosis (15 cells/mm3), slow background with frontal focalization on EEG, a left frontal ischemic lesion, leptomeningeal enhancement, and bilateral limbic fluid-attenuated inversion recovery hyperintensity on cerebral MRI. Reverse transcription-polymerase chain reaction for SARS-CoV-2 was positive in nasopharyngeal swab and COVID serology was positive for immunoglobulin (Ig) M and G, whereas extensive autoimmune antibody investigation was negative except for a positive low titer of anti-myelin oligodendrocyte glycoprotein in CSF and blood. The diagnosis of probable encephalitis associated to cerebral vasculitis after COVID infection was suggested and steroids pulse were started. She recovered within a few days. Six months later, she had moderate clinical sequels including persistent intermittent headaches, an isolated spatial deficit, and focal spikes on the EEG without argument for epilepsia. Conclusion A teenager without previous medical history presented with acute encephalitis with leptomeningitis and vasculitis after a recent COVID-19 infection. Steroids pulse therapy allowed clinical improvement. Cerebral MRI and EEG helped diagnosis, follow-up of the encephalitis, and evolution after treatment.

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• Type de publi. : Article dans une revue
• Date de publi. : 11/07/2022
• Auteurs : Marie UmberGersende PressatGuillaume FortKaïssa Plaisir PineauChantal GuiougiouFrédéric LambertBenoît FarinasJean-Philippe PichautBérenger JanzacJean-Marie DelosFrédéric SalmonCécile DuboisPierre-Yves Teycheney
• Organismes : Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques
• Publié dans Frontiers in Plant Science le 24/10/2020

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Résumé : Infectious alleles of endogenous banana streak viruses (eBSVs) are present in the genome of all banana interspecific cultivars, including plantains and cooking types. Activation of these infectious eBSV alleles by biotic and abiotic stresses leads to spontaneous infections by cognate viruses and raises concerns about their ability to promote outbreaks of banana streak viruses under field cultivation conditions. We undertook a comprehensive risk assessment study of infectious eBSV alleles of species BSOLV, BSGFV and BSIMV in banana interspecific cultivars in Guadeloupe, a tropical island of the Caribbean where bananas are grown for export and local markets. We carried out a prevalence survey of BSOLV, BSGFV and BSIMV species in a range of cultivars grown in Guadeloupe. Our results suggest that BSOLV and BSGFV infections arise from the activation of infectious eBSVs rather than vector-borne transmission and point to a correlation between altitude and infection rates in interspecific hybrids with AAB genotypes. We studied the dynamics of activation of infectious eBSOLV and eBSGFV alleles by tissue culture and field cultivation in a range of cultivars. We showed that tissue culture and field cultivation trigger distinct activation pathways, resulting in distinct activation patterns. We also showed that activation decreased over time during cell culture and field cultivation and that BSV infections arising from the activation of infectious eBSV alleles cause symptomless infections in the most cultivated plantain in Guadeloupe, French Clair. Overall, our study shows that the risk of BSV outbreaks resulting from the activation of infectious eBSVs in plantain originating from vegetative multiplication is negligible in Guadeloupe.

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Fichiers liés : 2022_Umber_Frontiers-in-Plant-Science.pdf

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