Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Bénédicte LelièvreCharlotte GodonPierre LegrasJeremie RiouDavid TernantJean-Philippe Bouchara
• Organismes : SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Département de Pharmacologie-Toxicologie [CHU Angers] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Micro et Nanomédecines Translationnelles Membrane Signalling and Inflammation in reperfusion Injuries Centre Hospitalier Régional Universitaire de Tours SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques
• Publié dans Biomedicine and Pharmacotherapy le 28/10/2020

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Résumé : Background: Posaconazole, a broad spectrum antifungal, may be used in salvage therapy for cerebral infections caused by Scedosporium species. In this study, its pharmacokinetics was investigated in a rat model of scedosporiosis to evaluate the effect of the infection on cerebral diffusion. Methods: Posaconazole was administered to two groups of rats randomized according to the infection status. Drug levels in plasma, cerebrospinal fluid, and brain tissue were measured up to 168 h after administration, and data were analyzed using a non-compartmental approach. In addition, interleukins (IL) (IL-1β and IL-10) were quantified by ELISA, and cerebral expression of genes encoding some efflux pumps was assessed by reverse transcription-quantitative PCR. Results: Cerebral diffusion of posaconazole and, to a lesser extent, cerebrospinal fluid exposure were significantly affected by infection. A ten-fold increase in the area under the curve and a delayed time (Tmax) to reach the maximum concentration (Cmax) were observed in the brain, along with a time lag to reach Cmax and Tmax between plasma and the brain. Infection was associated with changes in plasma pharmacokinetics, particularly at late sampling times. Conclusions: These findings suggest increased permeability of the blood-brain-barrier, possibly related to changes in IL or gene expression levels in the brain. Infection and the resulting inflammation should therefore be considered for therapeutic drug monitoring, especially in cases of cerebral infection.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Antoine GavoilleMikaïl NourredineFabien RollotRomain CaseyGuillaume MatheyAnne KerbratJonathan CironJérôme de SèzeBruno StankoffEdouard JanuelAurélie RuetPierre M LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrénayThibault MoreauDavid-Axel LaplaudEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana SarovKarolina HankiewiczCorinne PottierAmélie dos SantosÉric ManchonMaia TchikviladzeMuriel RabilloudFabien SubtilSandra Vukusic
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique [Nancy] Service de neurologie [Rennes] Neuroimagerie: méthodes et applications Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de Neurologie [Strasbourg] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Saint Vincent de Paul [Lille] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie [CHU Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Service de Neurologie [CHRU Besançon] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de neurologie [Reims] Service de Neurologie [CHU de Saint-Étienne] Hôpital Bretonneau Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] hôpital NOVO Service de neurologie [CHU de Poitiers] CIC Poitiers – Centre d'investigation clinique de Poitiers Centre Hospitalier de Gonesse Hôpital Foch [Suresnes] Alte University [Tbilissi] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Hospices Civils de Lyon Fondation Eugène Devic EDMUS
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : Background: Target trial emulation (TTE) offers a formal framework for causal inference using observational data, but its validity must be evaluated in each research domain by replicating randomised clinical trials (RCTs). We aimed to replicate eight RCTs evaluating the efficacy of disease-modifying therapies (DMTs) in multiple sclerosis (MS) using French registry data. Methods: This multicentre, retrospective, observational study was conducted using data extracted in December 2023 from the Observatoire Français de la Sclérose en Plaques (OFSEP) database. For each emulated trial, patients were included when they initiated one of the DMT evaluated in the corresponding RCT and met its inclusion criteria. Clinical outcomes were the annualised relapse rate and 3-month confirmed Expanded Disability Status Scale progression. Radiological outcomes were new/enlarged T2-lesions and new gadolinium-enhanced T1-lesions on a brain MRI. A targeted maximum likelihood estimator was used to estimate the treatment effect adjusted for confounding factors between groups and corrected for censoring and missing outcome assessment. Results: 14 111 patients were included in eight emulated trials: ASSESS (fingolimod vs glatiramer acetate), BEYOND (interferon beta vs glatiramer acetate), CONFIRM (dimethyl fumarate (DMF) vs glatiramer acetate), OPERA (ocrelizumab vs interferon beta), REGARD (interferon beta vs glatiramer acetate), RIFUND-MS (rituximab vs DMF), TENERE (teriflunomide vs interferon beta) and TRANSFORMS (fingolimod vs interferon beta). Treatment effects estimated in emulated trials were concordant with RCT findings in seven of eight trials for relapse rate, and in all six trials assessing disability progression. Radiological outcomes were more challenging to replicate; concordance was achieved in three of five trials for new T2-lesions, and one of four trials for new gadolinium-enhanced T1-lesions. Conclusion: The combined use of a TTE methodology and high-quality registry data is a valid tool to evaluate treatment effectiveness in MS.

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Fichiers liés : Gavoille et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Roel AaijAhmed Sameh Wagih AbdelmottelebCarlos Abellan BetetaFernando Jesus AbudinénThomas AckernleyAyomide Matthew AdefisoyeBernardo AdevaMarco AdinolfiPatrik Harri AdlarsonChristina AgapopoulouChristine Angela AidalaZiad AjaltouniSimon AkarKazuyoshi AkibaPietro AlbicoccoJohannes AlbrechtRamunas AleksiejunasFederico AlessioZakariya AliouchePaula Alvarez CartelleRenaud AmalricSandra AmatoJake Lewis AmeyYasmine AmhisLiupan AnLucio AnderliniMartin AnderssonPasquale AndreolaMirco AndreottiSergio Andres EstradaAlessia AnelliDong AoFlavio ArchilliZaratsyan AregMatteo ArgentonSergio Arguedas CuendisAlexander ArtamonovMarina ArtusoElie AslanidesRita Ataíde da SilvaMichele AtzeniBenjamin AudurierJuliette AuthierDavid BacherIrene Bachiller PereaSebastian BachmannMarie BachmayerJohn BackPablo Baladron RodriguezVladislav BalaguraAnna BalboniWander BaldiniLuca BalzaniHaoran BaoJuan Baptista de Souza LeiteCarlos Javier Barbero PretelMatteo BarbettiIvanildo Rui BarbosaRoger BarlowMikhail BarnyakovSergey BarsukWilliam BarterJustin BartzSaliha BashirBaasansuren BatsukhPiera BattistaAurelio BayAnja BeckMaik BeckerFranco BedeschiIgnacio BediagaNoah Albin BehlingSamuel BelinKonstantin BelousIlia BelovIvan BelyaevGaya BenaneGiovanni BencivenniEli Ben-HaimAlexander BerezhnoyRoland BernetSergi Bernet AndresAlessandro BertolinChristopher BetancourtFederico BettiJosh BexIaroslava BezshyikoOleg BezshyykoJihyun BhomMartin Stefan BiekerNicolo Vladi BiesuzPierre BilloirAlice BiolchiniMatthew BirchFionn Caitlin Ros BishopAlexander BitadzeAndrea BizzetiThomas BlakeFrederic BlancJonah Evan BlankSteven BluskVladimir BocharnikovJulian Alexander BoelhauveOscar Boente GarciaThomas BoettcherAbhishek BohareAlexey BoldyrevCarolina BolognaniRiccardo BolzonellaRiccardo BonacciNikolay BondarAleksandar BordeliusFederica BorgatoSilvia BorghiMartino BorsatoJozef Tomasz BorsukElia BottalicoSonia Amina BouchibaMarcelo BovillThemistocles BowcockAlexandre BoyerConcezio BozziJames Daniel BrandenburgAlexandre Brea RodriguezNils BreerJolanta BrodzickaArnau Brossa GonzaloJames David BrownDavide BrunduEmma BuchananLaura BuonincontriMarta Burgos MarcosAodhan Tomas BurkeChristopher BurrJordy Sebastiaan ButterJan BuytaertWiktor ByczynskiSandro CadedduHao CaiYuman CaiAlois CailletRoberto CalabreseSaul Calderon RamirezLukas CaleficeStefano CaliMarta CalviMiriam Calvo GomezPatricia Camargo MagalhaesJose Ivan Cambon BouzasPierluigi CampanaDaniel Hugo Campora PerezAngel Fernando Campoverde QuezadaSimone CapelliLorenzo CapriottiRonald Gerardo Caravaca-MoraAngelo CarboneLidia Carcedo SalgadoRoberta CardinaleAlessandro CardiniPaolo CarnitiLeon David CarusAdrian Casais VidalRowina CasparyGianluigi CasseMarco CattaneoGiovanni CavalleroViola CavalliniSara CelaniSara CesareAbbie Jane ChadwickIbrahim ChahrourHao ChangMatthew CharlesPhilippe CharpentierEvridki ChatzianagnostouRacha CheaibMaximilien ChefdevilleChen ChenJou-An ChenShanzhen ChenZewen ChenMostafa CherifAleksei ChernovSerhii ChernyshenkoXenofon ChiotopoulosVeronika ChobanovaMarcin ChrzaszczAleksei ChubykinVladimir ChulikovPaolo CiambroneXabier Cid VidalGregory CiezarekPierfrancesco CifraPeter ClarkeMarco ClemencicHarry CliffJoel ClosierCarlos Eduardo Cocha ToapaxiVictor CocoJulien CoganEric CognerasLucian CojocariuSpencer Edward CollavitiPaula CollinsTommaso ColomboMarco ColonnaAlbert Comerma-MontellsLiliana CongedoJames ConnaughtonAndrea ContuNaomi CookeChristian Andres CoronelImanol CorredoiraAnthony CorreiaGloria CortiJozie Cottee MeldrumBenjamin CouturierDaniel Charles CraikMelissa Maria Cruz TorresEsteban Curras RiveraRobert CurrieCesar Luiz da SilvaShakhzod DadabaevLingyun DaiXinchen DaiElena Dall'OccoJeremy DalsenoCarmelo d'AmbrosioJessy DanielPhilippe d'ArgentGabriella DarzeAlexander DavidsonJonathan Edward DaviesOscar de Aguiar FranciscoCamilla de AngelisFederico de BenedettiJan de BoerKristof de BruynStefano de CapuaMichel de CianUlisses de Freitas Carneiro da GracaErika de LuciaJussara de MirandaLeandro de PaulaMarilisa de SerioPatrizia de SimoneFabio de VellisJacco de VriesFrancesco DebernardisDaniel DecampSam Michael DekkersLuigi del BuonoBlaise DelaneyHans Peter DembinskiJianqiao DengVadym DenysenkoOlivier DeschampsFrancesco DettoriBiplab DeyPasquale Di NezzaIgor DiachkovSergey DidenkoShuchong DingYiyang DingLucas DittmannVasyl DobishukAleksandrina DochevaAlex Patrick DohenyChenzhi DongAmanda May DonohoeFrancesca DordeiAlberto dos ReisAndrew Jay DowlingLea Marie Sophie DreyfusWeisong DuanPiotr Jakub DudaMaciej Wojciech DudekLaurent DufourViacheslav DukPaolo DuranteMaciej DurasJohn Matthew DurhamOzgur DurmusAgnieszka DziurdaAlexey DzyubaSajan EasoEllinor EcksteinUlrik EgedeArtem EgorychevVictor EgorychevStephan EisenhardtEnoch EjopuLars EklundMohamed ElashriJan Hendrik EllbrachtScott ElyAlexandru EneJonas Nathanael EschleSevda EsenTimothy EvansFederica FabianoSaba FaghihLucas FalcaoBo FangRiccardo FantechiLisa FantiniMaria FariaKeira Gwyn FarmerDavide FazziniLukasz Jerzy FelkowskiMingjie FengMauricio FeoAlvaro Fernandez CasaniMiguel Fernandez GomezAlex Daniel FernezFabio FerrariFernando Ferreira RodriguesMartina FerrilloMassimiliano Ferro-LuzziSergey FilippovRosa Anna FiniMassimiliano FioriniMiroslaw FirlejKamil Leszek FischerDillon Scott FitzgeraldConor FitzpatrickTomasz FiutowskiFrederic FleuretAlex FominMarianna FontanaLucas Arthur ForemanRoger FortyDaniel Foulds-HoltVinicius Franco LimaManuel Franco SevillaMarkus FrankEdoardo FranzosoGiulia FrauChristoph FreiDavid Anthony FridayJinlin FuQuentin FühringTommaso FulghesuGiuliana GalatiMaria Domenica GalatiAbraham Gallas TorreiraDomenico GalliSilvia GambettaMiriam GandelmanPaolo GandiniBilal Ahmad GanieHan GaoRui GaoTian-Qi GaoYang GaoYuanning GaoYuxi GaoLuis Miguel Garcia MartinPaula Garcia MorenoJulián García PardiñasParker Taittinger GardnerKunal GargLluis GarridoClara GasparArsenii GavrikovLouis Lenard GerkenEvelina GersabeckMarco GersabeckTimothy GershonSimon GhizzoZahra GhorbanimoghaddamLuca GiambastianiFotis Ioannis GiasemisValerie GibsonHenryk Karol GiemzaAlexander Leon GilmanMatteo GiovannettiAlessandra GioventùLucas George GirardeyMaciej Artur GizaFabian Christoph GlaserVladimir GligorovCarla GöbelLarysa Golinka-BezshyykoElisabet GolobardesDmitry GolubkovAndrey GolutvinSergio Gomez FernandezWojciech GomulkaIsadora Gonçales VazFernanda Goncalves AbrantesMateusz GoncerzGuanghua GongJames Andrew GoodingIgor Vladimirovich GorelovClaudio GottiEkaterina GovorkovaJascha Peter GrabowskiLuis Alberto Granado CardosoEugeni GraugésElena GraveriniLuke GrazetteGiacomo GrazianiAlexandru Tudor GrecuLex Marinus GreevenNathan Allen GrieserLucia GrilloSergey GromovChenxi GuMarco GuariseLaetitia GuerryVasilisa GuliaevaPaul Andre GüntherAbdul-Kerim GuseinovEvgeny GushchinYury GuzThierry GysKai Sebastian HabermannThomas HadavizadehChristos HadjivasiliouGuido HaefeliChristophe HaenSamuel James HakenGeorge HallettPhoebe Meredith HamiltonJan HammerichQundong HanXiaoxue HanStephanie Hansmann-MenzemerLei HaoNeville HarnewThomas James HarrisMarie HartmannSabin HashmiJibo HeAndreea-Irina HedesFrederic HemmerConor HendersonRaoul HendersonRiley Dylan Leslie HendersonArthur Marius HennequinKarol HennessyLouis HenryJames Daniel HerdPaula Herrero GasconJohannes HeuelAdlène HicheurGuillermo Hijano MendizabalJoshua Ethan HorswillRuiwen HouYingrui HouDylan Cameron HoustonNed Francis HowarthJifeng HuWenhua HuXiaofan HuWouter HulsbergenRoss John HunterMikhail HushchynDavid HutchcroftMarek IdzikDmitrii IlinPhilip IltenAleksandr IniukhinArtur IshteevKuzma IvshinHendrik JageSergio Javier Jaimes EllesSune JakobsenEddy JansBrij Kishor JashalAbolhassan JawaheryChanka JayaweeraVukan JevticZekun JiaEmily Kaiyin JiangXiaojie JiangYi JiangYuyang JiangEsteban Jimenez MoyaNicholas JindalMalcolm JohnAllen Cris John Rubesh RajanDaniel JohnsonChristopher JonesSalil JoshiBeat JostJuan Jose Juan CastellaNathan JurikIzabela JuszczakDimitrios KaminarisSergii KandybeiMichael James 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LazzeroniRenaud Le GacHo Sang LeeRegis LefèvreAlexander LeflatSergey LegotinMarion LehurauxEdgar Lemos CidOlivier LeroyTadeusz LesiakEzra Douglas LesserBlake LeveringtonAnfeng LiChen LiChing-Hua LiHengne LiJiuzhao LiKechen LiLanxing LiManshu LiPeilian LiPei-Rong LiQinze LiTiange LiTianqi LiYanru LiYiming LiYujie LiZhengchen LianQiming LiangXixin LiangSimone LibralonAlisha LightbodyChuangxin LinTai-Hua LinRolf LindnerHenry James LintonRoman LitvinovDuanqing LiuFrank Xiangyu LiuGuoming LiuKai LiuShuaiyi LiuWeijie LiuYiming LiuYing LiuYiwei LiuGustavo Alejandro Loachamin OrdonezAniol Lobo SalviaAngelo LoiThomas LongFelipe Cesario Laterza LopesJose LopesAlbert Lopez HuertasCristina Lopez IribarnegaraySaúl López SoliñoQiuchan LuChiara LucarelliDonatella LucchesiMiriam Lucio MartinezYiheng LuoAnna LupatoEleonora LuppiKate LynchXiao-Rui LyuGe MaSerena MaccoliniFrederic MachefertFlorin MaciucBridget MackInnes MackayLauren Grace MackeyLakshan Ram Madhan MohanMarcus Jonathan MaduraiDaniel MagdalinskiDmitrii MaisuzenkoJakub Jacek MalczewskiSneha MaldeLorenzo MalentaccaAlexander MalininTimofei MaltsevGiulia MancaGiampiero MancinelliChiara MancusoRafel Manera EscaleroFederico ManganellaDaniele ManuzziDaniele MarangottoJean François MarchandRadoslav MarchevskiUmberto MarconiEdoardo MarianiSaverio MarianiCarla Marin BenitoJörg MarksAlexander Mclean MarshallLucas MartelGabriele MartelliGiuseppe MartellottiLoris MartinazzoliMaurizio MartinelliDaniel Guillermo Martinez GomezDiego Martinez SantosFernando Martinez VidalAlexia Martorell GranollersAndré MassafferriRosen MatevAbhijit MathadViacheslav MatiuninClara MatteuzziKara Renee MattioliAndrea MauriEmilie MauriceJoan MauricioPierre Paul Louis MayencourtJose Mazorra de CosMichal MazurekMichael MccannTamaki Holly McgrathNiall Thomas MchughAndrew McnabRonan McnultyBrian MeadowsGerwin MeierDmytro MelnychukDiego Mendoza GranadaFanjie MengMarcel MerkAndrea MerliLucas Meyer GarciaDexing MiaoHan MiaoMikhail MikhasenkoDiego Alejandro MilanesAlessandro MinottiElisa MinucciTristan MirallesBiljana MitreskaDominik Stefan MitzelAtanu ModakLeandra MoeserRazvan-Daniel MoiseEsteban Felipe Molina CardenasTitus MombächerMatthew David MonkStephane MonteilAngel Morcillo GomezGianfranco MorelloMichael Joseph MorelloMaurice Pierre MorgenthalerJakub MoronWouter MorrenAdam Benjamin MorrisAndrew George MorrisRaymond MountainHongjie MuZeqing MuEmir MuhammadFranz MuheimMick MulderKatharina MüllerFederico Muñoz-RojasRebecca MurtaViktor MytrochenkoParas NaikTatsuya NakadaRaja NandakumarTara NanutIrina NastevaMatthew NeedhamEvgeniia NekrasovaNicola NeriSebastian NeubertNiko NeufeldPetr NeustroevJanina NicoliniDavide NicotraElisabeth Maria NielNikolay NikitinQile NiuPedro NogarolliPiet NoggaCamille NormandJulio Novoa FernandezGabriel Matthew NowakCynthia NunezHavva Hasret NurAgnieszka Oblakowska-MuchaVladimir ObraztsovThomas OeserArtem OkhotnikovOleksandr OkhrimenkoRudolf OldemanFederica OlivaErnest Olivart PinoMicol OloccoGerco OnderwaterRyunosuke Hugo O'NeilJuan Sebastian Ordonez SotoDonata OsthuesJuan Martin Otalora GoicocheaPatrick OwenMaria Aranzazu OyangurenOzlem OzcelikFrancesco PaciollaAdam PadeeKlaas Ole PadekenBhagyashree PagareTommaso PajeroAntimo PalanoMatteo PalutanChucheng PanXiaofan PanStefano PanebiancoGennady PanshinLorenzo PaolucciAntonios PapanestisMarco PappagalloLuciano PappalardoCheryl PappenheimerChristopher ParkesDhruvanshu ParmarBarbara PassalacquaGiovanni PassalevaDaniele PassaroAlessandra PastoreMitesh PatelJairus Tristan PatocClaudia PatrignaniAntara PaulChristopher James PawleyAntonio PellegrinoJi PengXuanjia PengMonica Pepe AltarelliStefano PerazziniDmitrii PereimaHugo Pereira da CostaMaria Pereira MartinezAsier Pereiro CastroCilicia Uzziel PerezPascal PerretAnn-Kathrin PerrevoortAlberto PerroMichael Jacob PetersKonstantinos PetridisAlessandro PetroliniJacob PfallerHang PhamLorenzo PicaMauro PicciniLorenzo PiccoloBoleslaw PietrzykGuillaume PietrzykRiccardo Nunzio PilatoDavide PinciFlavio PisaniMarco PizzichemiVlad-Mihai PlacintaMaximo Plo CasasusThomas PoeschlFrancesco PolciMarco Poli LenerAnton PoluektovNatalia PolukhinaIvan PolyakovErica PolycarpoSebastien PonceDmitry PopovStanislav PoslavskiiKodassery PrasanthClaire ProuveDaniele ProvenzanoValery PugatchGiovanni PunziShah Rukh QasimQucheng QianWenbin QianNing QinSanqiang QuRenato QuaglianiRaul Iraq Rabadan TrejoRuta RaczJonas RademackerMatteo RamaManuel Ramírez GarcíaVictoria Ramos de OliveiraMiguel Ramos PernasMurilo RangelFedor RatnikovGerhard RavenMiguel Rebollo de MiguelFederico RediJake ReichFlorian ReissZan RenP.K ResmiMiquel Ribalda GalvezRoberto RibattiGabriel RicartDomenico RiccardiStefania RicciardiKate Abigail RichardsonMary Richardson-SlipperKurt RinnertPatrick RobbeGary RobertsonEduardo RodriguesAlejandro Rodriguez AlvarezEmilio Xose Rodriguez FernandezJairo Alexis Rodriguez LopezEfren Rodriguez RodriguezJonas Malte RoenschAlexander RogachevAlexander RogovskiyDavid Leonhard RolfPhilipp RoloffVladimir RomanovskiyAntonio Romero VidalGabriele RomoliniFederico RonchettiTianze RongMarcello RotondoShreya RoyMatthew Scott RudolphMiguel Ruiz DiazRamon Angel Ruiz FernandezJoan Ruiz VidalJose Javier Saavedra-AriasJuan Jose Saborido SilvaMedaer Sacha Emile R.Rita SadekNaylya SagidovaDebashis SahooNiladribihari SahooBiagio SaittaMatteo SalomoniIzaac SanderswoodRoberta SantacesariaCibran Santamarina RiosMarco SantimariaLeonardo SantoroEmanuele SantovettiAlessandro SaputiDanila SaraninAndrej SarnatskiyGediminas SarpisMindaugas SarpisCelestina SatrianoAlessia SattaMiroslav SaurDarya SavrinaHalime SazakFrancesco SborzacchiAlessandro ScarabottoStefan SchaelSigrid ScherlManuel SchillerHeinrich SchindlerMichael SchmellingBurkhard SchmidtSebastian SchmittHannah SchmitzOlivier SchneiderAndreas SchopperNicole SchulteMarie Helene SchuneGeorg SchweringBarbara SciasciaAugusto SciuccatiIlya SegalSara SellamAlexander SemennikovThomas Christian SengerMara Senghi SoaresAntonino SergiNicola SerraLorenzo SestiniAlex SeutheBorja Sevilla SanjuanYiduo ShangDesmond Mzamo ShangaseMikhail ShapkinRashi SharmaIvan ShchemerovLesya ShchutskaTara ShearsLev ShekhtmanZhihong ShenShuqi ShengVladimir ShevchenkoBoan ShiQi ShiWenjie ShiYuya ShimizuEvgenii ShmaninRoman ShorkinJoseph David ShupperdRafael Silva CoutinhoGabriele SimiSaverio SimoneMrityunjoy SinghaNicola SkidmoreTomasz SkwarnickiMark SlaterEluned SmithKrista Lizbeth SmithMark SmithLais Soares LavraMichael SokoloffPaul SolerAnatoly SolominAleksandr SolovevNiclas SommerfeldRongrong SongYunxuan SongYuxiang SongYintong SongFelipe Luan Souza de AlmeidaBruno Souza de PaulaKarol Mateusz SowaElisabetta Spadaro NorellaEugenia SpedicatoJannis Guido SpeerPatrick SpradlinViros SriskaranFederico StagniMarian StahlSascha StahlSeophine StanislausMaria Zofia StefaniakEloise Noelle SteinOlaf SteinkampHolger StevensDaria StrekalinaYangjie SuFidan SuljikJiayin SunJinyi SunLiang SunDaniel SundfeldWilliam SutcliffeKrzysztof SwientekFrancesca SwystunAdam SzabelskiTomasz SzumlakYinghua TanYingao TangYuxuan TangMartin Duy TatJuan Adrian Teijeiro JimenezAleksandr TerentevFrancesco TerzuoliFrederic TeubertEric ThomasDaniel James David ThompsonAlexander Robert Thomson-StrongHanae TilquinVincent TisserandStephane t'JampensMark TobinTodor Georgiev TodorovLuca TomassettiGiorgia TonaniXingyu TongTheraa TorkDiego Torres MachadoLuca Toscanoda Yu TouCarina TripplGiulia TuciNiels TuningLennart Henning UeckerArtur UklejaDaniel Joachim UnverzagtAbhinaba UpadhyayBenjamin UrbachAndrii UsachovAndrey UstyuzhaninUlrich UwerVincenzo VagnoniVictoria Valcarce CadenasGiovanni ValentiNuria Valls CanudasJan van EldikHubert van HeckeEric van HerwijnenCharlotte Barbara van HulseRaphael van LaakMaarten van VeghelGerardo VasquezRicardo Vazquez GomezPablo Vazquez RegueiroCarlos Vázquez SierraStefania VecchiJaap VelthuisMichele VeltriAravindhan VenkateswaranMichele VerdogliaMika VesterinenWren VetensDavid Vico BenetPol Vidrier VillalbaMaria Vieites 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• Organismes : Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
• Publié dans JHEP le 14/01/2026

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Résumé : A model-independent determination of the CKM angle $γ$ is presented, using the $B^\pm\to[K^+K^-π^+π^-]_D h^\pm$ and $B^\pm\to[π^+π^-π^+π^-]_D h^\pm$ decays, with $h=K,π$. This measurement is the first phase-space-binned study of these decay modes, and uses a sample of proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of $9$fb$^{-1}$. The phase-space bins are optimised for sensitivity to $γ$, and in each bin external inputs from the BESIII experiment are used to constrain the charm strong-phase parameters. The result of this binned analysis is $γ= (53.9_{-8.9}^{+9.5})^\circ$, where the uncertainty includes both statistical and systematic contributions. Furthermore, when combining with existing phase-space-integrated measurements of the same decay modes, a value of $γ= (52.6_{-6.4}^{+8.5})^\circ$ is obtained, which is one of the most precise determinations of $γ$ to date.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Vladimir ChekhovskyAram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerSuman ChatterjeeKonstantinos DamanakisMarko DragicevicPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonThomas van LaerPierre van MechelenNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongSteven LowetteInna MakarenkoDenise MüllerStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoClaudio CaputoJerome de Favereau de JeneretChristophe DelaereIzzeddin Suat DonertasAndrea GiammancoAhmet Oguz GuzelSandhya JainVincent LemaitreJindrich LidrychPaola MastrapasquaTu Thong TranSemra TurkcaparGilvan AlvesEduardo CoelhoGilson Correia SilvaCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorMapse Barroso Ferreira FilhoHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaTulio Laux KuhnMatheus MacedoJordan MartinsKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielCesar Augusto BernardesLuigi CalligarisThiago TomeiEduardo de Moraes GregoresIsabela Maietto 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MallampalliAbdollah MohammadiSusmita MondalGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinDzmitry BudkouskiIgor GolutvinIlya GorbunovVladimir KarjavineOlga KodolovaVladimir KorenkovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaVitaly SmirnovOleg TeryaevNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinGenady GavrilovVictor GolovtcovYury IvanovVictor KimVictor MurzinVadim OreshkinDmitry SosnovValentin SulimovLev UvarovAlexey VorobyevYuri AndreevAlexander DermenevSergei GninenkoNikolai GolubevAnton KarneyeuDmitrii KirpichnikovMikhail KirsanovNikolai KrasnikovIrina TlisovaAlexander ToropinTagir AushevKirill IvanovVladimir GavrilovNatalia LychkovskayaVladimir PopovAlexander ZhokinMarina ChadeevaRuslan ChistovSergey PolikarpovVladimir AndreevMaksim AzarkinMartin KirakosyanAdel TerkulovEdouard BoosViacheslav BunichevMikhail DubininLev DudkoVyacheslav KlyukhinOlga LukinaMaxim PerfilovViktor SavrinAlexander SnigirevGeorge VorotnikovVladimir BlinovTatyana DimovaAleksei KozyrevOlesia RadchenkoYuri SkovpenVassili KachanovSergei SlabospitskiiAndrey UzunianAnton BabaevVladislav BorshchDmitry Druzhkin
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Laboratoire d'Annecy de Physique des Particules
• Publié dans JHEP le 14/01/2026

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Résumé : Measurements are presented of the W and Z boson production cross sections in proton-proton collisions at a center-of-mass energy of 13.6 TeV. Data collected in 2022 and corresponding to an integrated luminosity of 5.01 fb$^{-1}$ with one or two identified muons in the final state are analyzed. The results for the products of total inclusive cross sections and branching fractions for muonic decays of W and Z bosons are 11.93 $\pm$ 0.08 (syst) $\pm$ 0.17 (lumi) $^{+0.07}_{-0.07}$ (acc) nb for W$^+$ boson production, 8.86 $\pm$ 0.06 (syst) $\pm$ 0.12 (lumi) $^{+0.05}_{-0.06}$ (acc) nb for W$^-$ boson production, and 2.021 $\pm$ 0.009 (syst) $\pm$ 0.028 (lumi) $^{+0.011}_{-0.013}$ (acc) nb for the Z boson production in the dimuon mass range of 60-120 GeV, all with negligible statistical uncertainties. Furthermore, the corresponding fiducial cross sections, as well as cross section ratios for both fiducial and total phase space, are provided. The ratios include charge-separated results for W boson production (W$^+$ and W$^-$) and the sum of the two contributions (W$^\pm$), each relative to the measured Z boson production cross section. Additionally, the ratio of the measured cross sections for W$^+$ and W$^-$ boson production is reported. All measurements are in agreement with theoretical predictions, calculated at next-to-next-to-leading order accuracy in quantum chromodynamics.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Arnaud BeddokJean Baptiste MorvanLaurys BoudinAntonio da Silva Ribeiro MotaPauline DutheilPhilippe GuilbertLaura RozenblumAdeline Theresette GuilbertMohamad ZalzaliPierre-Yves MarcyJuliette Thariat
• Organismes : Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804
• Publié dans International Journal of Radiation Oncology, Biology, Physics le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Denis AngoulvantEmmanuel PeyronnetBertrand CariouPierre AmarencoFranck BoccaraJean-Pierre BoisselAlexandre BastienEulalie CourcellesAlizée DiatchenkoAnne FilipovicsSolène Granjeon NoriotRiad KahoulGuillaume MahéLolita PortalSolène PorteYishu WangEmmanuelle BechetPhilippe Gabriel Steg
• Organismes : Centre Hospitalier Régional Universitaire de Tours Membrane Signalling and Inflammation in reperfusion Injuries Nova in silico [Lyon] Institut du Thorax [CHU Nantes] AP-HP - Hôpital Bichat - Claude Bernard [Paris] McMaster University [Hamilton, Ontario] Centre de Recherche Saint-Antoine Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] CHU Saint-Antoine [AP-HP] Nova in silico [Lyon] Novartis Pharma AG Nova in silico [Lyon] Nova in silico [Lyon] Nova in silico [Lyon] Nova in silico [Lyon] Nova in silico [Lyon] Centre d'Investigation Clinique [Rennes] Laboratoire Mouvement Sport Santé Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Novartis Pharma AG Nova in silico [Lyon] Nova in silico [Lyon] Nova in silico [Lyon] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Laboratoire de Recherche Vasculaire Translationnelle
• Publié dans European Journal of Preventive Cardiology le 25/10/2020

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Résumé : Aims: Inclisiran, an siRNA-targeting hepatic PCSK9 mRNA, reduces low-density lipoprotein cholesterol (LDL-C), but its effect on major adverse cardiovascular event (MACE) remains unconfirmed. The SIRIUS in-silico modelling program aimed to predict the efficacy of inclisiran on MACE in virtual patients with atherosclerotic cardiovascular disease (ASCVD). Methods: The SIRIUS simulation (NCT05974345) used a validated mechanistic model of ASCVD and lipid-lowering therapy (LLT) effects in a virtual population with established ASCVD and LDL-C ≥70 mg/dL. Each virtual patient served as their own control to compare inclisiran versus placebo as an adjunct to high-intensity statin therapy, alone or with ezetimibe over 5 years. The model did not account for non-adherence, recurrent events, or adverse effects. Results: Among 204 691 virtual patients, inclisiran was predicted to reduce LDL-C by 49.7% versus placebo (from 91.1 to 48.3 mg/dL). Relative to placebo, inclisiran was predicted to lower 5 years risk of 3-point MACE by 25.2% (11.3% vs. 14.9%), myocardial infarction by 34.8% (5.7% vs. 8.6%; HR 0.65), ischaemic stroke by 26% (2.6% vs. 3.4%; HR 0.74), and major adverse limb event by 34.1% (0.5% vs. 0.8%; HR 0.66). A 7.1% relative reduction of cardiovascular death was predicted (4.2% vs. 4.5%; HR 0.93). Conclusions: SIRIUS is the first in-silico simulation using a knowledge-based mechanistic model to predict the efficacy of LLT on cardiovascular outcomes in ASCVD. These findings offer early model-based prediction of inclisiran's potential cardiovascular benefit ahead of phase 3 outcome trials.

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Fichiers liés : zwaf783.pdf

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