Philippe Jean-Pierre

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• Type de publi. :
• Date de publi. : 06/10/2025
• Auteurs : Pierre BordenavePhilippe ChaumeilFrédéric RaspailFranck SalinArnaud DucanchezGuillaume SimioniMarloie OlivierNathalie KorboulewskyStéphane MatzFrédérique LouaultDavid ColosseAlexia MathouPierre TrichetJean-Yves GorêtJulie BossuFranck Perret
• Organismes : Unité expérimentale Forêt Pierroton Biodiversité, Gènes & Communautés Biodiversité, Gènes & Communautés Biodiversité, Gènes & Communautés Technologies et Méthodes pour les Agricultures de demain Ecologie des Forêts Méditerranéennes Ecologie des Forêts Méditerranéennes Ecosystèmes forestiers Ecosystèmes forestiers Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR Unité expérimentale Forêt Pierroton Interactions Sol Plante Atmosphère Ecologie des forêts de Guyane Ecologie des forêts de Guyane Environnement, Ville, Société

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Résumé : Ce poster qui est présenté aux J2M 2025, montre le réseau de stations instrumentées IoT low cost développées dans le cadre du projet ECOLOGGING pouvant réaliser des mesures de météorologie, de température et de niveau d'eau, de suivi du sol (en humidité et température) et de Gaz à Effet de Serre. Ces stations ont été déployées sur le territoire français, ainsi qu'en Guyane afin de les tester dans différents écosystèmes et conditions climatiques. Nous présentons également toute la chaîne d'acquisition sécurisée qui utilise un broker MQTTs, Node-Red, une base de données et Grafana. L'émission et la réception des données en 4G est fiable tout comme la récupération des données de l’ensemble des stations qui ont été déployées sur les différents sites, y compris en Guyane.

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Fichiers liés : BORDENAVE_ECOLOGGING POSTER 15092025.pdf

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• Type de publi. : Autre publication
• Date de publi. : 04/10/2025
• Auteurs : Sébastien QuenotCanarelli JulieLeandri YanPetru Couvidat-GherardiJean-Baptiste GeronimiDeborah CertoPhilippe SalortMarcandria PerautMadeleine FilippiPetru Couvidat-GherardiEugène GherardiJean-Baptiste GeronimiDeborah CertoPhilippe SalortChristophe LuziPierre-François MarchianiMarcandria PerautThibaut DauphinMichel Vergé-FranceschiJean-Guy TalamoniMadeleine Filippi
• Organismes : Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA)

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 02/10/2025
• Auteurs : Sébastien QuenotCouvidat-Gherardi PetruGherardi EugèneCanarelli JulieLeandri YanGeronimi Jean-BaptisteCerto DeborahSalort PhilippeLuzi ChristopheMarchiani Pierre-FrançoisPeraut MarcandriaDauphin ThibautVergé-Franceschi MichelTalamoni Jean-GuyFilippi Madeleine
• Organismes : Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Centre National de la Recherche Scientifique Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Università di Corsica Pasquale Paoli [Université de Corse Pascal Paoli] Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Institut de Recherche Montesquieu Université de Tours Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA)

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Claire ChatorMarion ChevrierJean-Sébastien FrénelFrédéric GuyonRenaud SabatierChristophe PomelThibault de la Motte RougePatricia PautierLaurence GladieffPhilippe FollanaPierre-Emmanuel ColomboThierry PetitCécile GuillemetF. MarchalFabrice NarducciJean-David FumetManuel RodriguesLise BosquetRoman RouzierIsabelle Ray-Coquard
• Organismes : LAboratoire PLasma et Conversion d'Energie Université Toulouse III - Paul Sabatier Communauté d'universités et établissements de Toulouse Plasmas Réactifs Hors Equilibre Research on Healthcare Performance
• Publié dans Gynecologic Oncology le 25/10/2020

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Résumé : Approximately 70 % of patients with epithelial ovarian cancer (EOC) will relapse. Beyond the platinum-free interval (PFI), predictive factors for efficacy of subsequent therapies are poorly understood. We evaluated the impact of the PFI on progression-free survival (PFS), overall survival (OS) and the role of therapies used at relapse.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Yuqing LiuXiaojun LiPhilippe CiaisFrédéric FrappartXiangzhuo LiuEric G. CosioYi ZhengZanpin XingHuan WangLei FanMario Julian ChaubellWigneron J.-P.
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère National Sun Yat-sen University Interactions Sol Plante Atmosphère Peking University [Beijing] Southwest University [Chongqing] Jet Propulsion Laboratory Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : The effective scattering albedo (omega) is a key parameter in the zero-order radiative transfer equation (known as the tau-omega model) for passive microwave retrieval of soil moisture (SM) and vegetation optical depth (VOD), quantifying the scattering energy loss as microwave radiation passes through the vegetation canopy. The scattering effects of vegetation are influenced by time-dependent factors such as plant geometry, vegetation water content, and canopy structure, suggesting that omega may vary over time. However, in the current tau-omega model-based retrieval algorithms used by orbiting L-band sensors, namely the Soil Moisture and Ocean Salinity (SMOS) and the Soil Moisture Active Passive (SMAP), omega is generally assumed to be time-invariant and assigned a fixed value according to land cover types. In this study, we aim to analyze and understand the spatio-temporal dynamics of omega, its relationship with vegetation water stress and the driving factors behind microwave scattering characteristics over tropical forests. By assuming a vegetation transmittance of zero for rigorously selected dense forest areas in the tropics, we calculated omega from the SMAP L-band radiometer observations during 2018-2023. Regarding the spatial distribution of omega, we observed distinct spatial dynamics within the same land cover type. The lowest omega values were typically found in the northeastern Amazon. Additionally, omega exhibited clear temporal dynamics, displaying a unimodal pattern in the Amazon and a bimodal pattern in the Congo. Clear polarization dependence of omega was observed, with values consistently higher at Horizontal (H-) polarization compared to Vertical (V-) polarization. Despite this, the seasonal patterns of omega are similar at both H- and V-polarizations. The seasonal variation of omega was found to be asynchronous with soil water availability indicated by root zone soil moisture (RZSM) across different regions. The shortest time lags (0-30 days) between omega and RZSM were observed in the densely vegetated northeastern Amazon, while the longest occurred in the northeastern Congo. A machinelearning based interpretation of the spatial variability of omega and time lag indicates that the values of omega are strongly and inversely related to canopy height, while the time lag is mainly associated with precipitation and soil water content. Our results deepen the understanding of the spatio-temporal dynamics of omega and could contribute to the improvement of SM and VOD retrieval algorithms, thereby enhancing the utility of these variables as indicators for monitoring vegetation carbon dynamics and phenology in dense tropical forests.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Jean-Yves BlayMaud ToulmondeThibaud ValentinNelly FirminSarah WatsonFlorence DuffaudEmmanuelle BompasMaria RiosMikael RoparsPhilippe AnractArmelle DufresneJustine GantzerLouis-Romée Le NailEsma SaadaAlice HervieuFrançois BertucciPascale Dubray-LongerasVincent CrennChristophe PerrinPauline SoibinetBenjamin VerretAntoine ItalianoGauthier DecanterGwenael FerronSebastien CarrereSylvie BonvalotMehdi BrahmiClémence HénonMariella Spalato-CerusoLoic LebellecAnne DucassouJulien Colard-ThomasSophie Piperno-NeumannJean-Camille MatteiFrancois GouinMathieu FaronThomas RyckewaertPierre MeeusCharles HonoréFrançois Le LoarerJean-Michel CoindreCarine NgoAlexandra MeurgeyMarie KaranianClaire Chemin-AiriauFrançoise DucimetiereMagali MorelleNicolas PenelAxel Le Cesne
• Organismes : Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Bergonié [Bordeaux] Institut Claudius Regaud Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut de Recherche en Cancérologie de Montpellier Institut régional de Cancérologie de Montpellier Institut Curie [Paris] Hôpital de la Timone [CHU - APHM] CRLCC René Gauducheau Centre Alexis Vautrin Hôpital Sud [CHU Rennes] Hôpital Cochin [AP-HP] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut de Cancérologie de Strasbourg Europe Centre Hospitalier Universitaire [Strasbourg] CHU Trousseau [Tours] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Centre de Recherche en Cancérologie de Marseille Institut Paoli-Calmettes Centre Jean Perrin [Clermont-Ferrand] Service des Urgences [CHU Nantes] Laboratoire Mécanismes d'Accidents Université Gustave Eiffel Institut Jean Godinot [Reims] Institut Gustave Roussy Institut Bergonié [Bordeaux] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut Claudius Regaud Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut de Recherche en Cancérologie de Montpellier Institut régional de Cancérologie de Montpellier Institut Curie [Paris] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Gustave Roussy Institut Bergonié [Bordeaux] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut Claudius Regaud Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut de Recherche en Cancérologie de Montpellier Institut régional de Cancérologie de Montpellier Institut Curie [Paris] Hôpital de la Timone [CHU - APHM] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Gustave Roussy Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Gustave Roussy Institut Bergonié [Bordeaux] Institut Bergonié [Bordeaux] Institut Gustave Roussy Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut Gustave Roussy
• Publié dans The Lancet Regional Health - Europe le 21/04/2021

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Résumé : Background Liposarcomas (LPS) are among the most common sarcomas, but gather a diversity of rare to ultrarare molecular subtypes whose presentations and natural histories are partially characterized. The aim of the work was to describe the presentation and outcome of the different LPS histotypes from the NETSARC+ registry. Methods NETSARC+ (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor boards (MDTB), funded by the French INCA since 2010 aiming to improve the quality of care of sarcoma patients. Patients' characteristics, treatment and outcomes are collected in a nationwide database. This work describes the outcome of all LPS confirmed by central review pathology review and integrated between 2010 and 2023 in the NETSARC+ database. Findings 11,132 liposarcomas are included in the database for an estimated incidence of 11.5/10 6 /y. Median age was 65 (Q1-Q3: 53-74, range 0-97 y), with 6529 males (58.7%), with 4220 (37.9%) dedifferentiated (DDLPS), 1838 (16.5%) well differentiated LPS (WDLPS) & 2424 (21.8%) atypical lipomatous tumours (ALT), 1371 (12.3%) myxoid LPS (MyxLPS), 450 (4.0%) pleomorphic LPS (PLPS), 177 (1.6%) high grade myxoid LPS (HGMLPS), 24 (0.2%) mixed type liposarcomas (MTLPS), 14 (0.1%) myxoid pleomorphic LPS (MPLPS) and 614 (5.5%) non classified LPS (NCLPS). Age, sex and sites differed across histotypes, but overall, all histotypes were represent in all age groups and sites. We report first on a difference in the sex ratio of liposarcoma in different age groups. Women were less frequently affected with liposarcomas after 50, in DDLPS, MyxLPS and HGMLPS. The median overall survival of DDLPS was 144 months, significantly worse than that of MyxLPS (HR: 0.26 [95% CI 0.21–0.33]), PLPS (HR: 0.76 [95% CI 0.59–0.98]), HGMLPS (HR: 0.30 [95% CI 0.18–0.50]), WDLPS (HR: 0.30 [95% CI 0.24–0.37]), unclassified LPS (HR: 0.53 [95% CI 0.37–0.75]). In addition to a lower incidence, women aged >50 had a better relapse free and overall survival than male, while this was not observed in the group aged 50 or under. In multivariate analyses, size and age were independent prognostic factors for the most common subgroups, but specific prognostic parameters were observed in each molecular subgroup. Female >50 was an independent favorable prognostic factor for the largest groups of DDLPS. Interpretation In this nationwide series of pathology-confirmed LPS, the clinical presentation, management and survival of histotypes are very different with age-related sex differences favoring women >50. DDLPS is the subtype with the worse prognosis

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Fichiers liés : main_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Antoine GavoilleFabien RollotRomain CaseyGuillaume MatheyEmmanuelle Le PageJonathan CironJérôme de SèzeAurélie RuetElisabeth MaillartPierre LabaugeHélène ZephirArnaud KwiatkowskiCaroline PapeixGilles DeferChristine Lebrun-FrenayThibault MoreauDavid-Axel LaplaudEric BergerAnne-Laure DubessyPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al-KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana Sarov-RiviereKarolina HankiewiczCorinne PottierAmélie dos SantosChantal NifleFabien SubtilSandra VukusicFrançois CottonPascal DouekF. GuilleminAlexandre PachotJavier OlaizClaire Rigaud-BullyRomain MarignierGuillaume MatheyAnne KerbratDamien BiottiJean-Christophe OualletNicolas CollonguesOlivier OutteryckXavier MoissetNathalie DeracheMikaël CohenAgnès FromontSandrine WiertlewskyMatthieu BereauBertrand AudoinClaire GiannesiniCaroline BensaGiovanni CastelnovoOmbeline FagniezBenjamin HebantMathieu VaillantSéverine JeaninAlain CréangeJean-Michel VallatPhilippe ConversStéphane BeltranCéline LabeyrieCarole HenryMarie CamuzeauxMaryline DelattreLaura TrottaCatherine GirodAmandine Ostermann-ZieglerDamien Le PortNoellie FreitasCarole BertheKaty-Kim LatasteKarima ZehrouniFrédéric PinnaJulie PetitSadou Safa DialloKarine DroulonCéline CallierAlexia ProtinMelinda MoyonChrystelle CappeEmilie DumontHanane AgherbiMarie BlanchereMarie-Pierre RanjevaAmandine da VeigaMaty Diop KaneChristine VimontMarjory CayolSafiyatou BaldeDaisy RousseauKarine FerraudGéraldine MeunierElise VarnierEdwige LescieuxHalima BourenaneStéphanie CossecEmilie RaboisLynda BenammarAnaïs Beulaygue
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique - Epidémiologie clinique [Nancy] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de Neurologie [Strasbourg] Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Saint Vincent de Paul [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie [CHU Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Service de Neurologie [CHRU Besançon] CHU Pitié-Salpêtrière [AP-HP] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de neurologie [Reims] Service de Neurologie [CHU de Saint-Étienne] Hôpital Bretonneau Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] hôpital NOVO Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CIC Poitiers – Centre d'investigation clinique de Poitiers Centre Hospitalier de Versailles André Mignot Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS
• Publié dans JAMA neurology le 24/10/2020

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Résumé : Importance: In women with multiple sclerosis (MS), disease-modifying therapy (DMT) management during pregnancy might impact relapse risk. Objective: To estimate the effect of DMT management during pregnancy on MS relapse rate and compare different therapeutic strategies. Design, setting, and participants: This was a multicenter retrospective cohort study using data from January 1990 to December 2023. Data were extracted in December 2023 from the French MS registry. Among 52 955 women in the registry, we included pregnancies identified through childbirths in patients with relapsing-onset MS who were monitored for at least 18 months before delivery and 9 months after. Pregnancies occurring less than 18 months apart or with missing month of birth were excluded. Exposures: Mediation analysis was used to estimate the total, direct, and indirect (mediated by DMT management) effects of pregnancy. Different therapeutic strategies were compared: DMT interruption, switching to or maintaining interferon β or glatiramer acetate, switching to or maintaining natalizumab until the third trimester, and switching to or maintaining intravenous anti-CD20 and interrupting it 3 months before conception. Main outcomes and measures: The primary outcome was the annualized relapse rate (ARR) during the preconception, gestation, and postpartum periods. Within a causal inference framework, counterfactual ARRs were estimated using longitudinal g-computation, combining a random forest algorithm for predicting DMTs, and a mixed-effects Poisson model for relapses. Results: We included 6341 pregnancies occurring in 4998 women (mean [SD] age at conception, 31.5 [4.5] years). DMT management during pregnancy significantly increased ARR during gestation (causal rate ratio [cRR], 1.13; 95% CI, 1.06-1.22) and postpartum (cRR, 1.08; 95% CI, 1.01-1.16) periods. This led to a deleterious total effect of pregnancy on ARR, particularly in women receiving natalizumab before pregnancy with prolonged interruption (ie, interruption before the second trimester or resumption more than 3 months after delivery; cRR, 2.18; 95% CI, 1.76-2.69), and in women receiving fingolimod (cRR, 2.15; 95% CI, 1.60-2.93). Compared to DMT interruption, anti-CD20 strategy was the most effective (cRR, 0.38; 95% CI, 0.25-0.52), followed by the natalizumab strategy with short interruption (cRR, 0.80; 95% CI, 0.71-0.90), whereas interferon β (cRR, 0.93; 95% CI, 0.86-0.99) and glatiramer acetate strategies (cRR, 0.91; 95% CI, 0.84-0.99) were less effective. Conclusion: In this study, DMT management during pregnancy significantly increased relapse risk, particularly in patients receiving natalizumab with prolonged interruption or fingolimod. The strategy based on the use of anti-CD20 before pregnancy was the most effective to mitigate this risk.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Salomon ManierJérôme LambertCyrille HulinMargaret MacroKamel LaribiCarla AraujoGian Matteo PicaCyrille TouzeauPascal GodmerBorhane SlamaLionel KarlinFrédéric Orsini PiocelleMamoun DibLaurence SanhesPierre MorelAbderazzak El YamaniMourad TiabReza TabriziValentine RichezLaurent GarderetBruno RoyerBenoit BareauClara MarietteEmmanuel FleckDaniela RobuClaire CalmettesSophie RigaudeauHelene DemarquetteLaurent FrenzelOlivier DecauxMohamad MohtyBertrand ArnulfNoémie BigotAurore PerrotJill CorreJean-Yves MaryHervé Avet-LoiseauPhilippe MoreauXavier LeleuThierry Facon
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Hospices Civils de Lyon Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Lancet Oncology le 02/11/2020

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Résumé : BACKGROUND: Patients with frailty and newly diagnosed multiple myeloma have worse outcomes due to higher rates of adverse events (AEs) and treatment discontinuation. This study evaluated a dexamethasone-sparing regimen of daratumumab plus lenalidomide versus lenalidomide plus dexamethasone in frail patients with newly diagnosed multiple myeloma. METHODS: In this prospective, randomised, open-label trial, conducted at 61 active Intergroup Francophone of Myeloma centres, patients aged 65 years or older with newly diagnosed multiple myeloma and an Eastern Cooperative Oncology Group proxy frailty score of 2 or more were randomly assigned 2:1 to receive daratumumab (1800 mg subcutaneously) plus oral lenalidomide (25 mg daily for 21 days of a 28 day cycle) and dexamethasone (20mg weekly) for two cycles (dexamethasone-sparing group) or lenalidomide (25 mg daily) and oral dexamethasone (20 mg weekly; control group), with stratification by International Staging System, age, and centre. The primary endpoint was progression-free survival. Efficacy was assessed in the intention-to-treat population and safety was assessed in all patients exposed to at least one dose of randomised intervention. This trial is registered with ClinicalTrials.gov, NCT03993912, and is complete. FINDINGS: From Oct 18, 2019 to July 20, 2021, 335 patients were screened, of whom 295 patients were randomly assigned (200 to lenalidomide plus daratumumab, 95 to lenalidomide plus dexamethasone). The median age was 81 years (IQR 77-84), with 180 (61%) aged older than 80 years, and 151 (51%) patients were female and 144 (49%) were male. Median follow-up was 46·3 months (IQR 46·0-52·7). Median progression-free survival was 53·4 months (95% CI 35·3-not reached) in the dexamethasone-sparing group versus 22·5 months (16·5-39·0) in the control group (hazard ratio [HR] 0·51, 95% CI 0·37-0·70, p<0·0001). The most common grade 3-5 AEs were neutropenia (110 [55%] of 200 patients in the dexamethasone-sparing group vs 23 [24%] of 95 patients in the control group), and infection (38 [19%] vs 20 [21%]). Serious adverse events occurred in 126 patients (63%) in the dexamethasone-sparing group and 66 patients (69%) in the control group. AEs leading to death occurred in 23 patients (12%) in the dexamethasone-sparing group and 12 patients (13%) in the control group, with 4 (2%) and 2 (2%) grade 5 treatment-emergent adverse events, respectively. INTERPRETATION: In the IFM2017-03 trial, use of lenalidomide plus daratumumab, with dexamethasone limited to the first 2 treatment cycles, reduced the risk of progression or death compared with lenalidomide plus dexamethasone, with no additional safety concerns. Lenalidomide plus daratumumab could therefore be considered as a treatment option for older patients with frailty and newly diagnosed multiple myeloma. FUNDING: The study was funded by Johnson and Johnson.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 24/09/2025
• Auteurs : Alexandre DurrmeyerJean-Christophe PalauquiPhilippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : The positioning of new cellular walls during cell division plays a key role in shaping plant tissue organization. The influence of cell geometry on the positioning of division planes has been previously captured into various geometrical rules. Accordingly, linking cell shape to division orientation has relied on the comparison between observed division patterns and predictions under specific rules. The need to define a priori the tested rules is a fundamental limitation of this hypothesis-driven approach. As an alternative, we introduce a data-based approach to investigate the relation between cell geometry and division plane positioning, exploiting the ability of deep neural network to learn complex relationships across multidimensional spaces. Adopting an image-based cell representation, we show how division patterns can be learned and predicted from mother cell geometry using a UNet architecture modified to operate on cell masks. Using synthetic data and A. thaliana embryo cells, we evaluate the model performances on a wide range of diverse cell shapes and division patterns. We find that the trained model accounted for embryo division patterns that were previously irreconcilable under existing geometrical rules. Our work shows the potential of deep networks to understand cell division patterns and to generate new hypotheses on the control of cell division positioning.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 23/09/2025
• Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczYiming AbulaitiBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaSonakshi AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhMelike AkbiyikTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoGuillaume Lucas AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeJonny AllenJulia Frances AllenPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaDante AmideiBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosKieran Robert AmosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioKonstantinos AxiotisAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerPaolo BagnaiaMarzieh BahmaniDaniel BahnerKehang BaiJohn BainesLuke BainesKeith BakerEvelin BakosDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzIsaac BamwidhiElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosMarta Baselga BacarditSaleh BashiriAhmed BassalatMatthew Joseph BassoSusan BatajuRussell BateRichard BatesSouad BatlamousMarco BattagliaDaariimaa BattulgaMatteo BauceMichael BauerPatrick BauerLukas BayerTomas BazzanoJames BeachamTristan BeauJean Yves BeaucampPierre-Hugues BeaucheminPhilip BechtleHans Peter BeckKathrin BeckerAndrew BeddallVadim BednyakovChris BeeLars BeemsterMarcia BegalliMichael BegelJanna Katharina BehrJoshua Falco BeirerFlorian BeisiegelMohamed BelfkirGideon BellaLorenzo BellagambaAlain BelleriveCasey Dominik BellgraphPanagiotis BellosKonstantin BeloborodovIlyas BenaoumeurDriss BenchekrounFatima BendebbaYan BenhammouKees BenkendorferLydia Audrey BeresfordMatteo Mario BerettaElin Bergeaas KuutmannNicolas BergerBenedikt Ludwig BergmannJuerg BeringerGregorio BernardiCatrin BerniusFlorian Urs BernlochnerAdrian Berrocal GuardiaTracey BerryPeter BertaAnne-Sophie BertholdAnnalisa BertiRaphael BertrandSiegfried BethkeAlessandra BettiAdrian BevanLucas BezioNaman Kumar BhallaShudhashil BharthuarSomadutta BhattaPrajita BhattaraiZubair BhattiKartik Deepak BhideVallary Shashikant BhopatkarRiccardo Maria BianchiGianluca BiancoOtmar BiebelMichela BigliettiSully BillingsleyYassine BimgdiMarcello BindiAnna BinghamAhmet BingulCesare BiniGareth Adam BirdMattias BirmanMarek BirosStanislav BiryukovTobias BisanzEmanuele BisceglieJyoti Prakash BiswalDiptaparna BiswasIngo BlochAndrew James BlueHeidrun BlumenscheinViktor BobrovnikovLucrezia BoccardoMichael BoehlerBurkhard BohmDanijela BogavacAlexander BogdanchikovLaura BoggiaVeronique BoisvertPetar BokanTomasz BoldMarco BombenMarcella BonaMaarten BoonekampAlbert Gyorgy BorbelyIurii BordulevGuennadi BorissovDaniela BortolettoDavide BoscheriniMartine Fernandez-BosmanKhalil BouaoudaNaseem BouchharLeo BoudetJoseph BoudreauEva Bouhova-ThackerDjamel Eddine BoumedieneRomain BouquetAntonio BoveiaJamie BoydDiallo BoyeIgor BoykoLeon BozianuJuraj BracinikNihal BrahimiGerhard Immanuel BrandtOleg BrandtBenjamin Paul BrauJim BrauRoy Schimmel BrenerLydia BrennerRichard BrennerShikma BresslerGreta BriantiDavid BrittonDaniel BritzgerIan BrockRaymond BrockGustaaf BrooijmansJammel BrooksEthan Michael BrooksLiza BrostLeesa BrownLaura Elaine BruceTim Lukas BrucklerPawel Bruckman de RenstromBen BruersAlessia BruniGraziano BruniDavid BrunnerMarco BruschiNello BruscinoTrygve BuanesQuentin BuatDaniel Alexander BuchinAndy BuckleyOleg BulekovBrendon BullardSergey BurdinCarsten BurgardAngela Maria BurgerBlake Oliver BurghgraveOleksandr BurlayenkoJared Dynes BurlesonJackson Carl BurzynskiElena Laura BuschVolker BuescherPeter John BusseyOliver ButJohn Mark ButlerCraig Macleod ButtarJonathan ButterworthWill ButtingerCarlos Josue Buxo VazquezAlexey BuzykaevSusana Cabrera UrbanLuca CadamuroHuacheng CaiYuchen CaiYizhou CaiValentina CairoOrhan CakirNoemi CalacePaolo CalafiuraGiovanni CalderiniPhilippe CalfayanLara CalicGiuseppe CalleaLuiz Pereira CalobaDavid CalvetSamuel CalvetReina Coromoto Camacho ToroStefano CamardaDaniel Camarero MunozPaolo CamarriClement CamincherMario CampanelliAlessandra CamplaniVincenzo CanaleAli Can CanbayEnzo CanoneroJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasMichael Patrick CardiffGiovandomenico CarducciTancredi CarliGiampaolo CarlinoJuan Ignacio CarlottoBen CarlsonEvan Michael CarlsonJoseph CarmignaniLeonardo CarminatiAlberto CarnelliMaria CarnesaleSascha CaronEdson Carquin LopezIsabel Beth CarrSonia CarraGiuseppe CarrattaClara Carrion MartinezAnthony Maurel CarrollPilar Casado LechugaPierluigi CasolaroMaximilian CasparFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreTom CavaliereViviana CavaliereLaura Juliana Caviedes BetancourtEmre CelebiSofia CellaVilius CepaitisKarel CernyAugusto Santiago CerqueiraAlex CerriLucio CerritoFabio CeruttiBeatrice CervatoAlberto CervelliGianmario CesariniSerkant CetinPaul Mickael ChabrillatRagansu 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CoelliLuca Sesto ColangeliBrian Andrew ColePablo Collado SotoJohann CollotMaria Rita ColucciaPatricia Conde MuinoMatt ConnellSimon ConnellEimear Isobel ConroyMichelle Contreras CossioFrancesco ConventiAmanda SarkarLorenzo CorazzinaFederico Andrea CorchiaArtur Cordeiro Oudot ChoiLouie Dartmoor CorpeMassimo CorradiFrancois CorriveauArely Cortes-GonzalezMaria Jose Costa MezquitaFrancesco CostanzaDavide CostanzoJeremy CouthuresGlen CowanKyle Stuart CranmerLucas CremerDavide CremoniniSabine Chrystel Crepe-RenaudinFrancesco CrescioliTommaso CrestaMarkus CristinzianiMarco CristoforettiEdoardo CritelliVincent Alexander CroftNanni CrosettiAna Rosario Cueto GomezHanfei CuiMaxwell CuiBetsy CunnettLiam CunninghamFrancesco CurcioJennifer Rachel CurranMario SousaJoao Victor da Fonseca PintoCinzia da ViaWladyslaw DabrowskiTomas DadoSalah-Eddine DahbiTiesheng DaiDaniele Dal SantoCarlo DallapiccolaMogens DamGabriele d'AmenValerio d'AmicoJeff DandoyMichele d'AndreaDominik DannheimGabriele d'AnniballeMatthias DanningerValerio DaoNanni DarboSruthy Jyothi DasFilippo DattolaSaverio d'AuriaAntonio d'AvanzoTomas DavidekJoel DavidsonIan DawsonKaushik DeCarolina de Almeida RossiRiccardo de AsmundisNicola de BiaseStefano de CastroNicolo de GrootPaul de JongHector de la Torre PerezAntonio de MariaAlessandro de SalvoUmberto de SanctisFrancesco de SantisAntonella de SantoJean-Baptiste de Vivie de RegieJernej DebevcDmitri DedovichJordy DegensAllison Mccarn DeianaJose del PesoLine DelagrangeFrederic DeliotChris Malena DelitzschMassimo Della PietraDomenico Della VolpeAndrea Dell'AcquaLidia Dell'AstaMarco DelmastroClaudia Caterina DeloguPierre Antoine DelsartSarah Marie DemersMikhail DemichevSerguei DenisovHaluk DenizliLouis D'EramoDominik Karol DerendarzFrederic DeruePaul DervanAman Mukeshbhai DesaiKlaus DeschFrancesco Armando Di BelloAnna Di CiaccioLucia Di CiaccioAntonio Di DomenicoCamilla Di DonatoAlessandro Di GirolamoGiulia Di GregorioAndrea Di LucaBiagio Di MiccoRoberto Di 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FrancavillaSimone FrancescatoStefano FranchellucciMatteo FranchiniSilvia FranchinoDavid FrancisLuca FrancoLaura FranconiMelissa FranklinGuglielmo FrattariYuval Yitzhak FridJohnny FriendNick FritzscheAlexander FrochDaniel FroidevauxJames FrostYao FuSebastian Julio Fuenzalida GarridoMinori FujimotoKin Yip FungEduardo Furtado De Simas FilhoMarin FurukawaJuan Fuster VerduAnne GaaAlessandro GabrielliAndrea GabrielliPhilipp GadowGuido GagliardiLouis-Guillaume GagnonSafa GaidSean GalantzanJames GallagherElizabeth GallasAxel GallenBruce Joseph GallopKock Kiam GanSanmay GangulyYanyan GaoAli GarabagluFrancisca Garay WallsCarmen GarciaAndrea Garcia AlonsoArianna Gemma Garcia CaffaroJose Enrique Garcia NavarroMiguel Angel Garcia RuizMaurice Garcia-SciveresGwen Llewellyn GardnerRobert William GardnerNicoletta GarelliRocky Bala GargJack GarganChristopher Andrew GarnerCameron Michael GarveyVeritas Katharina GassmannGabriella GaudioViveka GautamPaolo GauzziJan GavranovicIgor GavrilenkoAlexander 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GutierrezLuis Felipe Gutierrez ZagazetaManuel GutscheChristian GutschowClaire GwenlanCarl GwilliamEven Simonsen HaalandAndrew HaasMartin HabedankCarl HaberHaleh HadavandAbdelhamid HaddadAsma HadefAlina HaganJan Joachim HahnEmil HainesMahsana HaleemJoseph HaleyGregory HallewellJohn Andrew HallfordKenji HamanoHassane HamdaouiMatthias HamerSalah El Dine HammoudEmily HampshireJingyi HanLiangliang HanLiang HanShuo HanKazunori HanagakiMike HanceDhanush Anil HangalHamza HanifMichael Donald HankJorgen Beck HansenPeter HansenTorsten HarenbergSiarhei HarkushaMatthew Leary HarrisYnyr HarrisJack HarrisonNatalie Marie HarrisonPaul Fraser HarrisonMax HartNicole Michelle HartmanNikolai KrugRosie HasanYoji HasegawaFlorian HaslbeckSohaib HassanReiner HauserMatej HaviernikChris HawkesRichard HawkingsYuichiro HayashiDaniel HaydenChristopher Robyn HayesRobin HayesChris HaysJonathan HaysHelen HaywardMingxu HeYajun HeYi HeNathan HeatleyVincent HedbergJesse HeilmanSarah HeimTimon HeimJochen Jens 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JigginsMiguel Jimenez OrtegaJavier Jimenez PenaShan JinAdam JinaruOsamu JinnouchiPer Daniel Conny JohanssonKenneth JohnsJacob JohnsonFiona Ann JollyDominic JonesEleanor JonesKyle Scott JonesPaul JonesRoger JonesTim JonesHans Ludwig JoosRoshan JoshiJelena JovicevicXiangyang JuJohannes JunggeburthThomas JunkermannAurelio Juste RozasMonika Katarzyna JuzekSonia KabanaAnna KaczmarskaSadaf Aliah KadirMarumi KadoHarris KaganMichael KaganAbraham KahnChristian KahraToshiaki KajiEnrique Kajomovitz MustNilotpal KakatiNiraj KakotyIlia KalaitzidouSuman KandelNathan Jihoon KangDeepak KarEfstathios KarentzosKiran KarkiOsama KarkoutSergey KarpovZoya KarpovaVato KartvelishviliAndrey KaryukhinEirini KasimiJudith KatzySandeep KaurKentaro KawadeMayuri Prabhakar KawaleChihiro KawamotoTatsuo KawamotoEllis KayStergios KazakosVassili KazaninJames Michael KeaveneyRichard KeelerGustavs KehrisJohn Stakely KellerMitch KellyJacob Julian KempsterOldrich KepkaJustin KerrBenjamin Philip KerridgeBorut Paul KersevanLucia KeszeghovaRaees Ahmad KhanAlexander KhanovAlexey KharlamovTatyana KharlamovaElham KhodaMarina KholodenkoTeng Jian KhooGia KhoriauliYoussef KhoulakiYahya A.R KhwairaBeatty KibirigeDoyeong KimDongwon KimYoung-Kee KimNaoki KimuraMatthew Kevin KingstonAndreas KirchhoffChristian KirfelFlorian KirfelJulie Hart KirkAndrei KiryuninSayuka KitaOleh KivernykMartin KlassenChristoph Thomas KleinLucas KleinMatthew Henry KleinSamuel Byrne KleinUta KleinAlexei KlimentovTatiana KlioutchnikovaPeter KluitStefan KluthEmmerich KneringerTimothy Michael KnightAndrea Helen KnueMichael KobelDmitrii KobylianskiiSimon KochMartin KocianPeter KodysDaniela KockThomas KoffasOrcun KolayIro KoletsouTomas KomarekKarsten KoenekeAlbert KongTakanori KonoNikolaos KonstantinidisPantelis KontaxakisBalazs KonyaRevital KopelianskyStefan Zenon KopernyKrzysztof Marian KorcylKostas KordasAndreas KornSteffen KornIlya KorolkovNatalia KorotkovaBryan KortmanOliver KortnerSandra KortnerWill KosteckaMatus KostovVadim KostyukhinAnastasia KotsokechagiaAshutosh KotwalAimilianos KoulourisAthina Kourkoumeli-CharalampidiChristine KourkoumelisVangelis KourlitisOndrej KovandaBob KowalewskiWitold KozaneckiAnatoli KozhinViktor KramarenkoGregor KrambergerPeter KramerMieczyslaw Witold KrasnyAttila KrasznahorkayJack KrausJohanna Wanda KrausJakub KremerNils Benedikt KrengelTom KresseLukas KretschmannJan KretzschmarPeter KriegerKarol KrizkaKevin Alexander KroeningerHubert KrohaJiri KrollIra Joseph KrollKyle Stuart KrowpmanUladzimir KruchonakHans KruegerNils Erik KrumnackMark KruseOlesia KuchinskaiaSinan KudaySusanne KuehnRoman KustersThorsten KuhlVictor KukhtinYuri KoultchitskiSerguei KuleshovJudith KullEshita Vinay KumarMukesh KumarNeelam KumariPriyanka KumariAlexander KupcoAndrey KupichOleg KuprashHisaya KurashigeLeonid KurchaninovOleksii KurdyshAnastasia KurovaMasahiro KuzeAudrey Katherine KvamJiri KvitaNicholas KyriacouMounia LaassiriCarlos Lacasta LlacerFrancesco LacavaHeiko Markus LackerDidier LacourNisha Nareshbhai LadEvgueni LadyginArthur LafargeBertrand LaforgeTheodota LagouriFatima Zahra LahbabiStan LaiWei Sheng LaiJoseph Earl LambertSabine Wedam LammersWalter LamplChristos LampoudisGeorgios LamprinoudisAlec LancasterEric LanconUlrich LandgrafMurrough LandonValerie LangAndrew James LankfordFrancesco LanniKerstin LantzschAgostino LanzaMarta Lanzac BerrocalJean-Francois LaporteTommaso LariDag LarsenLauren LarsonFederico Lasagni ManghiMario LassnigSean Dean LawlorRoxani LazaridouMassimo LazzaroniEric LeHieu LeElise Maria Le Boulicaut EnnisLuc Tomas Le PottierBlaz LebanFabienne LedroitTing Fung LeeLerothodi Leonard LeeuwMichel LefebvreCharles LeggettGiovanna Lehmann MiottoMatthew LeighWilliam Axel LeightWaltteri LeinonenAnthony LeisosMarco Lisboa LeiteClara Elisabeth LeitgebRupert LeitnerKatharine LeneyTatjana LenzSandra LeoneChristos LeonidopoulosAlexander LeopoldJeremie Harmond Lepage BourbonnaisRobert LesChristopher LesterMikhail LevchenkoJessica LevequeLorne LevinsonGiacomo 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Tobias WinterMatthias WittgenMarkus WobischThomas WojtkowskiZef WolffsJulian WollrathMarcin WolterHelmut WoltersMarcus Clark WongEleanor Luise WoodwardSteven WormBarbara Krystyna WosiekKrzysztof Wieslaw WozniakSebastian WozniewskiKenneth Gibb WraightChufan WuChonghao WuJian WuMinlin WuMengqing WuSau Lan WuShaoguang WuXingyu WuJerry WuYusheng WuZhibo WuZuofei WuJonas WurzingerTerry WyattBenjamin Michael WynneStefania XellaLigang XiaMingzhe XieAnni XiongDa XuHao XuLailin XuRiley XuTairan XuYue XuZhongyukun XuRui XueBruce Donald YabsleySahal YacoobYohei YamaguchiErika YamashitaHiroki YamauchiTomohiro YamazakiYuji YamazakiSiyuan YanZhen YanHaijun YangHongtao YangSiqi YangTianyi YangXiao YangXuan YangYi-Lin YangYifan YangWei-Ming YaoCaley Luce YardleyJingbo YeShuwei YeXinmeng YeYoran YehIvan YeletskikhBeomki YeoMelissa YexleyTom Philip YildirimKohei YoritaChristopher YoungCharlie YoungNathan YoungYi YuJiarong YuanMan YuanRui YuanLuzhan YueMohamed ZaazouaBartlomiej Henryk ZabinskiImane ZahirAlessandro ZaioZuzanna Katarzyna ZakTamar ZakareishviliStefano ZambitoJilberto Zamora-SaaJiaqi ZangRiccardo ZanzotteraOta ZaplatilekChristian ZeitnitzHao ZengTodd ZengerOleg ZeninTibor ZenisSeth ZenzDirk ZerwasMingjie ZhaiDengfeng ZhangGengyuan ZhangJie ZhangJinlong ZhangLuxin ZhangLei ZhangPeng ZhangRui ZhangSijing ZhangTingyu ZhangYulei ZhangYuwen Ebony ZhangYangfan ZhangYixiang ZhangZhirong ZhangZhuolin ZhangZhiqing Philippe ZhangHaoran ZhaoTongbin ZhaoYuzhan ZhaoZhengguo ZhaoZihan ZhaoAlexey ZhemchugovJinchao ZhengKai ZhengXiangxuan ZhengZhi ZhengDewen ZhongBing ZhouHao ZhouNing ZhouYan ZhouYong ZhouYou ZhouJunjie ZhuXuliang ZhuYifan ZhuYingchun ZhuXuai ZhuangKonstantin ZhukovNikolai ZimineJoachim ZinsserMichal ZiolkowskiLidija ZivkovicAntonio ZoccoliKnut ZochAngelos ZografosTheodore ZorbasOlga ZormpaLukasz Zwalinski
• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de 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Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : The ATLAS experiment has performed a measurement of coherent exclusive $J/ψ\toμ^+μ^-$ production in ultraperipheral Pb+Pb collisions at $\sqrt{s_{\textrm{NN}}}=5.36$ TeV. The data was recorded at the Large Hadron Collider (LHC) during 2023, and corresponds to an integrated luminosity of 78 $μ$b$^{-1}$. Exclusive $J/ψ$ candidates were selected with a dedicated track-sensitive trigger based on the ATLAS transition radiation tracker. The analysis involves reconstruction of the dimuon invariant mass based on muon tracks from the inner detector, as the muon transverse momentum range of interest precludes the use of the standard muon reconstruction and identification algorithms. Differential cross sections are measured as a function of $J/ψ$ rapidity and are compared with theoretical predictions. After extrapolation to $\sqrt{s_{\textrm{NN}}}=5.02$ TeV, they are also compared with previous measurements performed by other experiments using data from LHC Run 2. While the results agree reasonably well with theoretical predictions, they are in tension with previous Run-2 results for the central rapidity region.

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