Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Mickaël AlligonNizar MahlaouiVirginie CourteilleLaurence CostesVeronica AfonsoPhilippe RandrianomenjanaharyNathalie de VergnesAnja RanohavimparanyDuy VoInès HafsaPerrine BachVincent BenoitNicolas GarcelonAlain FischerWadih Abou-ChahlaDaniel AdoueNathalie AladjidiCorinne Armari-AllaVincent BarlogisSophie BayartYves BertrandStéphane BlancheDamien BodetBernard BonnotteRaphaël BoriePatrick BoutardDavid BoutboulClaire BriandetJean-Paul BrionJacques BrouardLiana CarausuMartin CastellePascal CathébrasEmilie CatherinotNathalie CheikhMorgane CheminantSarah Cohen-BeaussantThibault ComontLouis-Jean CoudercPierre CougoulGérard CouillaultLionel CrevonElisa DemonchyAnne DevilleCatherine DevoldereEric DoreFabienne DulieuIsabelle DurieuNatacha Entz-WerléClaire FieschiFanny FouyssacPierre FrangeVincent GajdosLionel GalicierVirginie GandemerMartine GardembasCatherine GaudBernard GrosboisAurélien GuffroyCorinne GuittonGaëlle GuillermÉric HachullaMohamed HamidouSophie HaroYves HatchuelOlivier HermineCyrille HoarauArnaud HotSébastien HumbertArnaud JaccardJean-Philippe JaisSarah JannierSerge JacquotRoland JaussaudPierre-Yves JeandelEric JeziorskiKamila KebailiAnne-Sophie KorganowOlivier LambotteFanny LanternierClaire LarrocheDavid LaunayEmmanuelle Le MoigneAlain Le QuellecEmmanuelle Le MoigneVincent Le MoingYvon LebranchuMarc LecuitGuillaume LefèvreJean-Daniel LelièvreRichard LemalValérie Li-Thiao-TeOlivier LortholaryLuminita LucaCoralie MallebrancheMarion MalphettesAude Marie-CardineNicolas Martin-SilvaAgathe MasseauFrançoise MazingueEtienne MerlinGérard MichelFrédéric MillotCharline MiotBéatrice MonlibertFabrice MonpouxDespina MoshousLuc MouthonMartine MünzerRobert NavarroBénédicte NevenDalila NouarRaphaële Nove-JosserandEric OksenhendlerMarie Ouachée-ChardinAnne PagnierMarlène PasquetIsabelle PellierYves PerelAntoinette PerlatChristophe PiguetDominique PlantazSophie RivièrePascal RoblotPierre-Simon RohrlichBruno RoyerValéry SalleFrançoise Sarrot-ReynauldAmélie ServettazJean-Louis StephanNicolas SchleinitzHarry SokolFelipe SuarezLaure SwiaderSophie TaqueCaroline ThomasOlivier TournilhacCaroline ThumerelleJean-Pierre VannierJean-François Viallard
• Organismes : Centre de Recherche des Cordeliers Imagine - Institut des maladies génétiques
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Bertrand GuidetChristian JungHans FlaattenJesper FjølnerAntonio ArtigasBernardo Bollen PintoJoerg SchefoldMichael BeilSviri SigalPeter Vernon van HeerdenWojciech SzczeklikMichael JoannidisSandra OeyenEumorfia KondiliBrian MarshFinn AndersenRui MorenoMaurizio CecconiSusannah LeaverDylan de LangeAriane BoumendilPhilipp EllerMichael JoannidisDieter MesottenPascal ReperSandra OeyenWalter SwinnenHelene BrixJens BrushoejMaja VillefranceHelene Korvenius NedergaardAnders Thais BjerregaardIda Riise BallebyKasper AndersenMaria Aagaard HansenStine UhrenholtHelle BundgaardJesper FjølnerAliae HusseinRehab SalahYasmin Khairy Nasr Eldin Mohamed AliKyrillos WassimYumna ElgazzarSamar TharwatAhmed AzzamAyman Abdelmawgoad HabibHazem Maarouf AbosheaishaaMohammed AzabSusannah LeaverArnaud GalboisTomas UrbinaCyril CharronEmmanuel GuerotGuillaume BeschJean-Philippe RigaudJulien MaizelMichel DjibréPhilippe BurtinPierre GarconSaad NseirXavier ValetteNica AlexandruNathalie MarinMarie VaissiereGaëtan PlantefeveThierry VanderlindenIgor JurcisinBuno MegarbaneAnais CaillardArnaud ValentMarc GarnierSebastien BessetJohanna OzielJean-Herlé RaphalenStéphane DaugerGuillaume DumasBruno GoncalvesGaël PitonEberhard BarthUlrich GoebelEberhard BarthAnselm KunsteinMichael SchusterMartin WelteMatthias LutzPatrick MeybohmStephan SteinerTudor PoernerHendrik HaakeStefan SchallerStefan SchallerStefan SchallerDetlef Kindgen-MillesChristian MeyerMuhammed KurtKarl Friedrich KuhnWinfried RanderathJakob WollbornZouhir DindaneHans-Joachim KabitzIngo VoigtGonxhe ShalaAndreas FaltlhauserNikoletta RovinaZoi AidoniEvangelia ChrisanthopoulouAntonios PapadogoulasMohan GurjarAta MahmoodpoorAbdullah Khudhur AhmedBrian MarshAhmed ElsakaSigal SviriVittoria ComelliniAhmed RabhaHazem AhmedSilvio Namendys-SilvaAbdelilah GhannamMartijn GroenendijkMarieke ZegersDylan de LangeAlexander Daniel CornetMirjam EversLenneke HaasTom DormansWillem DieperinkLuis RomundstadBritt SjøbøFinn AndersenHans Frank StrietzelTheresa OlasveengenMichael HahnMiroslaw CzuczwarRyszard GawdaJakub KlimkiewiczMaria de Lurdes Campos SantosAndré GordinhoHenrique SantosRui AssisAna Isabel Pinho OliveiraMohamed Raafat BadawyDavid Perez-TorresGemma GomàMercedes Ibarz VillamayorAngela Prado MiraPatricia Jimeno CuberoSusana Arias RiveraTeresa TomasaDavid IglesiasEric Mayor VázquezCesar AldecoaAida Fernández FerreiraBegoña Zalba-EtayoIsabel Canas-PerezLuis Tamayo-LomasCristina Diaz-RodriguezSusana SanchoJesús PriegoEnas AbualqumbozMomin Majed Yousuf HillesMahmoud SalehNawfel Ben-HamoudaAndrea RobertiAlexander DullenkopfYvan FleuryBernardo Bollen PintoJoerg SchefoldMohammed Al-Sadawi
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Intensive Care Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Florence AderMaude Bouscambert-DuchampMaya HitesNathan Peiffer-SmadjaFrance MentréCharles BurdetJérôme AboabFlorence AderHafid Ait-OufellaAntoine AltdorferClaire AndréjakPascal AndreuLaurent ArgaudFirouzé Bani-SadrDrifa BelhadiLeila BelkhirFrançois BenezitMarc BernaMathieu BlotElisabeth Botelho-NeversLila BouadmaOlivier BouchaudDavid BougonKevin BouillerFanny Bounes-VardonMaude Bouscambert-DuchampDavid BoutoilleAlexandre BoyerSandra BrazCédric BruelCharles BurdetAndré CabiéEmmanuel CanetCharles CazanaveCyrille ChabartierCatherine ChirouzeRaphaël Clere-JehlDominique CostagliolaSandrine Couffin-CadièrguesJohan CourjonFlora CrockettFrançois DanionAline DechanetAgathe DelboveJean DellamonicaChristelle DelmasAlpha DialloFélix DjossouClément DubostAlexandre DuvignaudAlexander EgleOlivier EpaulardLoïc EpelboinHélène EsperouMurielle FartoukhKarine FaureEmmanuel FaureJoao-Miguel Ferreira RibeiroTristan FerryCécile FickoSamy FigueiredoClaire FougerouVincent FraipontBenjamin GaboritRostane GaciAmandine Gagneux-BrunonSébastien GallienDenis GarotAlexandre GaymardGuillaume GeriSébastien GibotFrançois GoehringerMarie GousseffRichard GreilDidier GrusonJérémie GuedjYves HansmannOlivier HinschbergerMaya HitesStéphane JaureguiberryVanessa JeanmichelMichael JoannidisSolen KernéisAntoine KimmounKada KloucheMarie LachâtreKarine LacombeFabrice LaineBernd LamprechtJ.P. LanoixOdile LaunayBruno LaviolleMinh-Patrick LêVincent Le MoingJérôme Le PavecYves Le TulzoPaul Le TurnierDavid LebeauxBenjamin LefevreSylvie LeroyFrançois-Xavier LescureHenry LessireBenjamin LeveauBruno LinaPaul LoubetAlain MakinsonDenis MalvyCharles-Hugo MarquetteGuillaume Martin-BlondelMartin MartinotJulien MayauxArmand Mekontso-DessapFrance MentréNoémie MercierFerhat MezianiJean-Paul MiraJean-Michel MolinaXavier MonnetJoy MootienBruno MourvillierBruno MourvilliersMarlène Murris-EspinJean-Christophe NavellouMarion NoretSaad NseirWalid OulehriJosé-Artur PaivaNathan Peiffer-SmadjaThomas PerpointGilles PeytavinGilles PialouxBenoît PilmisVincent PiriouLionel PirothJulien PoissyValérie PourcherJean-Pierre QuenotFrançois RaffiJean ReignierJean ReuterMatthieu RevestJean-Christophe RichardBéatrice Riu-PoulencCéline RobertPierre-Alexandre RogerClaire RogerRoberto Roncon-AlbuquerqueElisabeth RouveixYvon RuchNadia SaidaniJuliette SaillardNaomi SayreEric SennevilleAlbert SottoThérèse StaubFrancois StefanCharles TacquardNicolas TerziJulien TextorisGuillaume ThieryJean-François TimsitViolaine TolsmaSarah TubianaJean-Marie TurmelFlorent ValourFanny Vardon-BounesPriyanka VelouGil VerscheldenFlorent WalletGuilhem WattecampsYazdan YazdanpanahYoann Zerbib
• Organismes : Hospices Civils de Lyon Centre International de Recherche en Infectiologie Centre International de Recherche en Infectiologie Université libre de Bruxelles = Free University of Brussels Infection, Anti-microbiens, Modélisation, Evolution Imperial College London AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN régulateurs bactériens et médecine
• Publié dans The Lancet Infectious Diseases le 29/10/2020

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Fichiers liés : 2022 Ader et al., Final results.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Wan‐hsuan LuKelly Virecoulon GiudiciJohn MorleySophie GuyonnetAngelo PariniGeetika AggarwalAndrew NguyenYan LiRandall BatemanBruno VellasPhilipe Barreto de SoutoBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFranҫoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanYves RollandCharlotte DupuyCéline CaillaudPierre-Jean OussetFranҫoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFranҫoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFranҫois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFranҫois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Universitaire de Toulouse Washington University School of Medicine [Saint Louis, MO] Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Washington University School of Medicine [Saint Louis, MO] Saint Louis University Washington University School of Medicine [Saint Louis, MO] Saint Louis University Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP)
• Publié dans GeroScience le 30/10/2020

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Résumé : We investigated combining a core AD neuropathology measure (plasma amyloid-beta [Aβ] 42/40) with five plasma markers of inflammation, cellular stress, and neurodegeneration to predict cognitive decline. Among 401 participants free of dementia (median [IQR] age, 76 [73-80] years) from the Multidomain Alzheimer Preventive Trial (MAPT), 28 (7.0%) participants developed dementia, and 137 (34.2%) had worsening of clinical dementia rating (CDR) scale over 4 years. In the models utilizing plasma Aβ alone, a tenfold increased risk of incident dementia (nonsignificant) and a fivefold increased risk of worsening CDR were observed as each nature log unit increased in plasma Aβ levels. Models incorporating Aβ plus multiple plasma biomarkers performed similarly to models included Aβ alone in predicting dementia and CDR progression. However, improving Aβ model performance for composite cognitive score (CCS) decline, a proxy of dementia, was observed after including plasma monocyte chemoattractant protein 1 (MCP1) and growth differentiation factor 15 (GDF15) as covariates. Participants with abnormal Aβ, GDF15, and MCP1 presented higher CCS decline (worsening cognitive function) compared to their normal-biomarker counterparts (adjusted β [95% CI], - 0.21 [- 0.35 to - 0.06], p = 0.005). In conclusion, our study found limited added values of multi-biomarkers beyond the basic Aβ models for predicting clinically meaningful cognitive decline among non-demented older adults. However, a combined assessment of inflammatory and cellular stress status with Aβ pathology through measuring plasma biomarkers may improve the evaluation of cognitive performance.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiAntonio Fernandez DumontSilvia FedericiDafni Maria KagkliAnna LanzoniNikoletta PapadopoulouTommaso Raffaello
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : The GMO Panel has previously assessed genetically modified (GM) cotton DAS-24236-5 9 DAS-21Ø23-5 and concluded that it is as safe as its conventional counterpart and other appropriate comparators with respect to potential effects on human and animal health and the environment in the context of its intended uses. On 17 November 2020, the European Commission requested EFSA to evaluate new DNA sequence information and updated bioinformatics data for cotton DAS-24236-5 9 DAS-21Ø23-5 and to indicate whether the conclusions of the GMO Panel on the previously assessed cotton DAS-24236-5 9 DAS-21Ø23-5 remain valid. The new sequence data of DAS-24236-5 showed the change of one nucleotide that results in one amino acid substitution, in the newly expressed Cry1F (synpro_L620Q) compared to the sequence originally reported. The GMO Panel concludes that this amino acid substitution in the protein is a mutation. Nonetheless with the exception of the bioinformatics analysis, the studies performed for the risk assessment of Cry1F in cotton DAS-24236-5 9 DAS-21Ø23-5 remain valid. In addition, the new sequencing data showed a change in one nucleotide in the 5 0 flanking region of DAS-21Ø23-5 compared to the original sequence reported on the stack cotton DAS-24236-5 9 DAS-21Ø23-5. The bioinformatic analyses of the newly sequenced DAS-21Ø23-5 event in the stack DAS-24236-5 9 DAS-21Ø23-5 shows that the nucleotide difference is in the 5 0 flanking region outside the ORFs that span the 5 0 junction and is therefore not considered further in the safety assessment. Based on the information provided, the GMO Panel concludes that the corrected sequence does not give rise to any safety concerns, and therefore, the original risk assessment of cotton DAS-24236-5 9 DAS-21Ø23-5 remains valid.

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Fichiers liés : EFSA Journal - 2022 - - Assessment of new sequencing information for genetically modified cotton DAS‐24236‐5 DAS‐21 23‐5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Emilie BurelPhilippe ColsonJean-Christophe LagierAnthony LevasseurMarielle BedottoPhilippe Lavrard-MeyerPierre-Edouard FournierBernard La ScolaDidier Raoult
• Organismes : Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Aix-Marseille Université - École de médecine Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Viruses le 01/11/2020

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Résumé : Genetic recombination is a major evolutionary mechanism among RNA viruses, and it is common in coronaviruses, including those infecting humans. A few SARS-CoV-2 recombinants have been reported to date whose genome harbored combinations of mutations from different mutants or variants, but only a single patient’s sample was analyzed, and the virus was not isolated. Here, we report the gradual emergence of a hybrid genome of B.1.160 and Alpha variants in a lymphoma patient chronically infected for 14 months, and we isolated the recombinant virus. The hybrid genome was obtained by next-generation sequencing, and the recombination sites were confirmed by PCR. This consisted of a parental B.1.160 backbone interspersed with two fragments, including the spike gene, from an Alpha variant. An analysis of seven sequential samples from the patient decoded the recombination steps, including the initial infection with a B.1.160 variant, then a concurrent infection with this variant and an Alpha variant, the generation of hybrid genomes, and eventually the emergence of a predominant recombinant virus isolated at the end of the patient’s follow-up. This case exemplifies the recombination process of SARS-CoV-2 in real life, and it calls for intensifying the genomic surveillance in patients coinfected with different SARS-CoV-2 variants, and more generally with several RNA viruses, as this may lead to the appearance of new viruses.

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Fichiers liés : viruses-14-01266-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Samir JaberMarc GarnierKarim AsehnouneFanny BounesLouis BuscailJean-Baptiste ChevauxClaire Dahyot-FizelierLucie DarrivereMatthieu JabaudonOlivier Joannes-BoyauYoann LauneyEric LevesquePhilippe LevyPhilippe MontraversLaurent MullerThomas RimmeléClaire RogerCéline Savoye-ColletPhilippe SeguinJean-Pierre TasuRonan ThibaultGeoffroy VanbiervlietEmmanuel WeissAudrey de Jong
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Institut des Maladies Métaboliques et Casdiovasculaires Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Physiopathologie et Epidémiologie des Maladies Respiratoires Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques / Pathophysiology of Injury-induced Immunosuppression Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Centre de recherche sur l'Inflammation Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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Résumé : Objective: To provide guidelines for the management of the intensive care patient with severe acute pancreatitis.Design: A consensus committee of 22 experts was convened. A formal conflict-of-interest (COI) policy was developed at the beginning of the process and enforced throughout. The entire guideline construction process was conducted independently of any industrial funding (i.e. pharmaceutical, medical devices). The authors were required to follow the rules of the Grading of Recommendations Assessment, Development and Evaluation (GRADE®) system to guide assessment of quality of evidence. The potential drawbacks of making strong recommendations in the presence of low-quality evidence were emphasised.Methods: The most recent SFAR and SNFGE guidelines on the management of the patient with severe pancreatitis were published in 2001. The literature now is sufficient for an update. The committee studied 14 questions within 3 fields. Each question was formulated in a PICO (Patients Intervention Comparison Outcome) format and the relevant evidence profiles were produced. The literature review and recommendations were made according to the GRADE® methodology.Results: The experts' synthesis work and their application of the GRADE® method resulted in 24 recommendations. Among the formalised recommendations, 8 have high levels of evidence (GRADE 1+/-) and 12 have moderate levels of evidence (GRADE 2+/-). For 4 recommendations, the GRADE method could not be applied, resulting in expert opinions. Four questions did not find any response in the literature. After one round of scoring, strong agreement was reached for all the recommendations.Conclusions: There was strong agreement among experts for 24 recommendations to improve practices for the management of intensive care patients with severe acute pancreatitis.

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Fichiers liés : 2022 Jaber et al., Guidelines for.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : François-Xavier ChauvièreDenis BlantMyriam Boudadi-MaligneFrédéric BrenetJean‐christophe CastelDeak JuditBastien JakobMarc LuetscherJulien SpielmannValéry UldryEstelle VuilleumierSonia WüthrichPhilippe Zuppinger
• Organismes : Office du patrimoine et de l’archéologie du canton de Neuchâtel, section archéologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Muséum d'Histoire Naturelle de Genève
• Publié dans Cavernes le 18/11/2022

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Résumé : La grotte des Plaints (Couvet) est, avec celle de Cotencher (Rochefort), l’autre cavité neuchâteloise à avoir livré les vestiges d’occupations humaines attribués au Paléolithique moyen. Les nouvelles fouilles entreprises sur ce site en 2021 sont significatives du tournant opéré par l’archéologie cantonale depuis dix ans. Elles prennent place au sein d’un projet interdisciplinaire de valorisation et d’étude d’une caverne au potentiel scientifique très important, juste effleuré par les travaux qui y ont été menés dans les années 1950-1960

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Florence AderMaude Bouscambert-DuchampMaya HitesNathan Peiffer-SmadjaFrance MentréCharles BurdetJérôme AboabFlorence AderHafid Ait-OufellaAntoine AltdorferClaire AndréjakPascal AndreuLaurent ArgaudFirouzé Bani-SadrDrifa BelhadiLeila BelkhirFrançois BenezitMarc BernaMathieu BlotElisabeth Botelho-NeversLila BouadmaOlivier BouchaudDavid BougonKevin BouillerFanny Bounes-VardonMaude Bouscambert-DuchampDavid BoutoilleAlexandre BoyerSandra BrazCédric BruelCharles BurdetAndré CabiéEmmanuel CanetCharles CazanaveCyrille ChabartierCatherine ChirouzeRaphaël Clere-JehlDominique CostagliolaSandrine Couffin-CadièrguesJohan CourjonFlora CrockettFrançois DanionAline DechanetAgathe DelboveJean DellamonicaChristelle DelmasAlpha DialloFélix DjossouClément DubostAlexandre DuvignaudAlexander EgleOlivier EpaulardLoïc EpelboinHélène EsperouMurielle FartoukhKarine FaureEmmanuel FaureJoao-Miguel Ferreira RibeiroTristan FerryCécile FickoSamy FigueiredoClaire FougerouVincent FraipontBenjamin GaboritRostane GaciAmandine Gagneux-BrunonSébastien GallienDenis GarotAlexandre GaymardGuillaume GeriSébastien GibotFrançois GoehringerMarie GousseffRichard GreilDidier GrusonJérémie GuedjYves HansmannOlivier HinschbergerMaya HitesStéphane JaureguiberryVanessa JeanmichelMichael JoannidisSolen KernéisAntoine KimmounKada KloucheMarie LachâtreKarine LacombeFabrice LaineBernd LamprechtJ.P. LanoixOdile LaunayBruno LaviolleMinh-Patrick LêVincent Le MoingJérôme Le PavecYves Le TulzoPaul Le TurnierDavid LebeauxBenjamin LefevreSylvie LeroyFrançois-Xavier LescureHenry LessireBenjamin LeveauBruno LinaPaul LoubetAlain MakinsonDenis MalvyCharles-Hugo MarquetteGuillaume Martin-BlondelMartin MartinotJulien MayauxArmand Mekontso-DessapFrance MentréNoémie MercierFerhat MezianiJean-Paul MiraJean-Michel MolinaXavier MonnetJoy MootienBruno MourvillierBruno MourvilliersMarlène Murris-EspinJean-Christophe NavellouMarion NoretSaad NseirWalid OulehriJosé-Artur PaivaNathan Peiffer-SmadjaThomas PerpointGilles PeytavinGilles PialouxBenoît PilmisVincent PiriouLionel PirothJulien PoissyValérie PourcherJean-Pierre QuenotFrançois RaffiJean ReignierJean ReuterMatthieu RevestJean-Christophe RichardBéatrice Riu-PoulencCéline RobertPierre-Alexandre RogerClaire RogerRoberto Roncon-AlbuquerqueElisabeth RouveixYvon RuchNadia SaidaniJuliette SaillardNaomi SayreEric SennevilleAlbert SottoThérèse StaubFrancois StefanCharles TacquardNicolas TerziJulien TextorisGuillaume ThieryJean-François TimsitViolaine TolsmaSarah TubianaJean-Marie TurmelFlorent ValourFanny Vardon-BounesPriyanka VelouGil VerscheldenFlorent WalletGuilhem WattecampsYazdan YazdanpanahYoann Zerbib
• Organismes : Dynamic Microbiology - EA 7380
• Publié dans The Lancet Infectious Diseases le 29/10/2020

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Fichiers liés : 2022 Ader et al., Final results.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Romain DonneMaëva Saroul-AinamaPierre CordierAdel HammouteneChristelle KaboreMira StadlerIvan NemazanyyIsabelle Galy-FaurouxMounia HerragTobias RiedlMarie Chansel-da CruzStefano CarusoStéphanie BonnafousRupert ÖllingerRoland RadKristian UngerAlbert TranJean-Pierre CoutyPhilippe GualValérie ParadisSéverine Celton-MorizurMathias HeikenwalderPatrick RevyChantal Desdouets
• Organismes : Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de recherche sur l'Inflammation Centre de Recherche des Cordeliers German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Structure Fédérative de Recherche Necker Centre de Recherche des Cordeliers Imagine - Institut des maladies génétiques (IHU) German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Imagine - Institut des maladies génétiques (IHU) Centre de Recherche des Cordeliers Centre méditerranéen de médecine moléculaire Klinikum rechts der Isar Klinikum rechts der Isar Helmholtz Zentrum München = German Research Center for Environmental Health Centre méditerranéen de médecine moléculaire Centre de Recherche des Cordeliers Centre méditerranéen de médecine moléculaire Centre de recherche sur l'Inflammation Hôpital Beaujon [AP-HP] Centre de Recherche des Cordeliers German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Imagine - Institut des maladies génétiques (IHU) Centre de Recherche des Cordeliers
• Publié dans Developmental Cell le 31/10/2020

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Résumé : Non-alcoholic steatotic liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD has a major effect on the intrinsic proliferative properties of hepatocytes. Here, we investigated the mechanisms underlying the activation of DNA damage response during NAFLD. Proliferating mouse NAFLD hepatocytes harbor replication stress (RS) with an alteration of the replication fork's speed and activation of ATR pathway, which is sufficient to cause DNA breaks. Nucleotide pool imbalance occurring during NAFLD is the key driver of RS. Remarkably, DNA lesions drive cGAS/STING pathway activation, a major component of cells' intrinsic immune response. The translational significance of this study was reiterated by showing that lipid overload in proliferating HepaRG was sufficient to induce RS and nucleotide pool imbalance. Moreover, livers from NAFLD patients displayed nucleotide pathway deregulation and cGAS/STING gene alteration. Altogether, our findings shed light on the mechanisms by which damaged NAFLD hepatocytes might promote disease progression.

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Fichiers liés : Donne et al., Dev Cell.pdf

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