Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 30/06/2022
• Auteurs : Thierry BoulainMai-Anh NayPierre-François DequinJean-Baptiste LascarrouPhilippe VignonToufik KamelGrégoire MullerStephan EhrmannOlivier BaudinSylvie CalvatChristophe CraccoArnault DesachyCharles LafonEmmanuelle BoitrouArnaud FollinHervé MentecOlivier PajotGaëtan PlantefèveMarina ThirionRémi BruyèreJean-Pierre QuenotKonstantinos BachoumasMaud FiancetteJean Claude LacheradeChristine LebertLaurent Martin-LefèvreJean ReignierIsabelle VinatierAihem YehiaEmmanuelle BegotRemy BellierMarc ClavelBruno FrançoisAntoine GalyNicolas PichonPatrick BardouFrédéric BellecMichel BonnivardAnne MarcoJérôme RoustanSylvie VimeuxAnne BretagnolArmelle MathonnetNicolas BercaultToufik KamelGrégoire MullerFrançois RéminiacIsabelle RungeMarie SkarzynskiDelphine ChatellierRémi CoudroyJean-Pierre FratVéronique GoudetRené RobertAnne VeinsteinVlad BotocStéphanie ChevalierFrançois ColletJean-Paul GouelloJulie BadinAntoine GuillonAnnick LegrasElodie MasseretEmmanuelle MercierPatrice Talec
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre de recherche en éducation de Nantes
• Publié dans Annales de Biologie Clinique le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 30/06/2022
• Auteurs : Johanna NoelAnne JouinotJérôme AlexandreGuillaume UlmannMarie BretagneZahra Castel-AjgalSixtine de PercinClémentine Vaquin-VillemineyMarie-Pierre RevelMichael PeyromaurePascaline Boudou-RouquetteJennifer ArrondeauIthar GataaJean-Philippe DurandFrançois GoldwasserOlivier Huillard
• Organismes : Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Institut Cochin Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Centre de Recherche des Cordeliers Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Institut Cochin Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Centre de Recherche des Cordeliers Cancer Research and Personalized Medicine - CARPEM [Paris] Hôpital Cochin [AP-HP] Cancer Research and Personalized Medicine - CARPEM [Paris]
• Publié dans Cancers le 21/10/2020

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Résumé : Background: Nivolumab improved patients’ survival in metastatic renal cell carcinoma (mRCC). We aimed to evaluate resting energy expenditure (REE) (i.e., patients’ basal metabolism) to predict efficacy. Methods: We conducted a monocentric, observational study of mRCC patients receiving nivolumab between October 2015 and May 2020. REE was measured prior to initiating immunotherapy using indirect calorimetry to determine hypo, normo and hypermetabolism. Primary endpoint was 6-month, progression-free survival (PFS), and secondary endpoints were response rate, PFS and overall survival (OS). Results: Of the 51 consecutive patients, 15 (29%) were hypermetabolic, 24 (47%) normometabolic, and 12 (24%) hypometabolic. The 6-month PFS was 15% for hypermetabolic patients and 65% for non-hypermetabolic patients (p < 0.01). In the multivariate analysis, hypermetabolism was the only baseline factor predicting 6-month PFS (OR 9.91, 95%CI [1.62–60.55], p = 0.01). Disease progression was noted as the best response in 73% of hypermetabolic patients and 26% of non-hypermetabolic patients (p = 0.02). Median PFS was 2.8 and 8.7 months (p < 0.01), and median OS was 20.2 and 35.1 months (p = 0.13) in the hypermetabolic and non-hypermetabolic groups, respectively. Conclusions: Our study identifies an association between mRCC patients’ energy expenditure and nivolumab efficacy. The measurement of REE by indirect calorimetry in routine practice could help identify patients at risk of nivolumab failure.

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Fichiers liés : cancers-14-03214.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/06/2022
• Auteurs : Anne-Lise BienvenuPatricia PaveseGilles LeboucherPierre BergerSandrine RouxAlexandre CharmillonLuc ForoniJean MenottiDavid LebeauxRémi MayanVéronique MondainChristine RobinPhilippe LespritSerge AlfandariSolen Kernéis
• Organismes : Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Synthèse de Molécules d'Intérêt Thérapeutique Université Claude Bernard Lyon 1 Hospices Civils de Lyon
• Publié dans Journal of Medical Microbiology le 25/10/2020

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Résumé : Introduction. Antifungal stewardship programmes are needed in healthcare facilities to limit the overuse or misuse of antifungals, which are responsible for an increase in antifungal resistance. Hypothesis/Gap Statement. Core recommendations for antifungal stewardship were published by the Mycoses Study Group Education and Research Consortium, while the Centers for Disease Control and Prevention (CDC) provided a Core Elements of Hospital Antibiotic Stewardship Programs checklist. The recommendations offer global core elements for best practices in antifungal stewardship, but do not provide a framework for the implementation of antifungal stewardship programmes in healthcare facilities. Aim. In line with the recommendations, it is of the utmost importance to establish a practical checklist that may be used to implement antifungal stewardship programmes. Methodology. The practical checklist was established by a national consensus panel of experts involved in antifungal stewardship activities. A preliminary checklist was sent to all experts. The final document was approved by the panel after discussion and the resolution of any disagreements by consensus. Results. The final checklist includes the following items: leadership support; actions to support optimal antifungal use; actions to monitor antifungal prescribing, use and resistance; and an education programme. Conclusion. This antifungal stewardship checklist offers opportunities for antifungal resistance containment, given that antifungal stewardship activities promote the optimal use of antifungals.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Guillaume CoutanceMatteo PozziMatthieu AubryElisabeth Hugon-ValletRaluca MocanLara ChalabreyssePhilippe PortranJean-François ObadiaOlivier ThaunatNicolas GirerdValérie DuboisLaurent Sebbag
• Organismes : Hôpital Louis Pradel [CHU - HCL] Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Hospices Civils de Lyon Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] Hospices Civils de Lyon Groupement Hospitalier Lyon-Est Hôpital Louis Pradel [CHU - HCL] Hospices Civils de Lyon Hospices Civils de Lyon Centre International de Recherche en Infectiologie Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI] Université Claude Bernard Lyon 1 Service de Transplantation, Néphrologie et Immunologie Clinique [Lyon] Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Etablissement français du sang - Auvergne-Rhône-Alpes Hôpital Louis Pradel [CHU - HCL]
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : Introduction: De novo anti-HLA donor specific antibodies (DSA) have been inconsistently associated with cardiac allograft vasculopathy (CAV) and long-term mortality. We tested whether C3d-binding de novo DSA were associated with CAV or long-term-survival. Methods: We included 282 consecutive patients without preformed DSA on coronary angiography between 2010 and 2012. Angiographies were classified according to CAV ISHLT grading. The primary outcome was a composite criterion of severe CAV or mortality. As the impact of de novo antibodies should be assessed only after appearance, we used a Cox regression with time-dependent covariables. Results: Of the 282 patients, 51(18%) developed de novo DSA during follow-up, 29 patients had DSA with C3d-binding ability (DSA+C3d+), and 22 were without C3d-binding ability (DSA+C3d-). Compared with patients without DSA, DSA+C3d+ patients had an increased risk for the primary outcome of severe CAV or mortality (adjusted HR = 4.31 (2.40–7.74) p < 0.001) and long-term mortality (adjusted HR = 3.48 (1.97–6.15) p < 0.001) whereas DSA+C3d- did not (adjusted HR = 1.04 (0.43–2.47) p = 0.937 for primary outcome and HR = 1.08 (0.45–2.61) p = 0.866 for mortality). Conclusion: According to this large monocentric study in heart transplant patients, donor specific antibodies were associated with worse clinical outcome when binding complement. DSA and their complement-binding ability should thus be screened for to optimize heart transplant patient follow-up.

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Fichiers liés : jcm-11-03731.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Hui YangPhilippe CiaisJean-Pierre WigneronJérôme ChaveOliver CartusXiuzhi ChenSassan S SaatchiJulia GreenYuanyuan HuangEmilie JoetzjerHeather KayDavid MakowskiFabienne MaignanMaurizio SantoroShengli TaoQingling SunYitong Yao
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Evolution et Diversité Biologique Gamma Remote Sensing Research and Consulting AG National Sun Yat-sen University Southwest Forestry University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Commonwealth Scientific and Industrial Research Organisation [Australia] Centre national de recherches météorologiques Aberystwyth University Mathématiques et Informatique Appliquées Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Gamma Remote Sensing Research and Consulting AG Evolution et Diversité Biologique Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] National Sun Yat-sen University
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : The 2015/16 El Niño brought severe drought and record-breaking temperatures in the tropics. Here, using satellite-based L-band microwave vegetation optical depth, we mapped changes of above-ground biomass (AGB) during the drought and in subsequent years up to 2019. Over more than 60% of drought-affected intact forests, AGB reduced during the drought, except in the wettest part of the central Amazon, where it declined 1 y later. By the end of 2019, only 40% of AGB reduced intact forests had fully recovered to the predrought level. Using random-forest models, we found that the magnitude of AGB losses during the drought was mainly associated with regionally distinct patterns of soil water deficits and soil clay content. For the AGB recovery, we found strong influences of AGB losses during the drought and of γ . γ is a parameter related to canopy structure and is defined as the ratio of two relative height (RH) metrics of Geoscience Laser Altimeter System (GLAS) waveform data—RH25 (25% energy return height) and RH100 (100% energy return height; i.e., top canopy height). A high γ may reflect forests with a tall understory, thick and closed canopy, and/or without degradation. Such forests with a high γ ( γ ≥ 0.3) appear to have a stronger capacity to recover than low- γ ones. Our results highlight the importance of forest structure when predicting the consequences of future drought stress in the tropics.

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Fichiers liés : 2022_Yang_PNAS.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Gabriel IchimBenjamin GibertSahil AdriouchCatherine BrennerNathalie DavoustSolange DesagherDavid DevosSvetlana DokudovskayaLaurence DubrezJérôme EstaquierGermain GilletIsabelle GuénalPhilippe JuinGuido KroemerPatrick LegembreRomain LevayerStéphen ManonPatrick MehlenOlivier MeuretteOlivier MicheauBernard MignotteFlorence Nguyen-KhacNikolay PopgeorgievJean-Luc PoyetMuriel PriaultJean-Ehrland RicciFranck RiquetSantos A. SusinMagali SuzannePierre VacherLudivine WalterBertrand Mollereau
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques Laboratoire de biologie et modélisation de la cellule Institut de Génétique Moléculaire de Montpellier Lille Neurosciences & Cognition - U 1172 Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques Lipides - Nutrition - Cancer [Dijon - U1231] Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire Centre de Recherche en Cancérologie de Lyon Hospices Civils de Lyon Laboratoire de génétique et biologie cellulaire École Pratique des Hautes Études Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Centre de Recherche des Cordeliers Contrôle de la Réponse Immune B et des Lymphoproliférations Cellules Souches et Développement / Stem Cells and Development Institut de biochimie et génétique cellulaires Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire de génétique et biologie cellulaire École Pratique des Hautes Études Centre de Recherche des Cordeliers CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche en Cancérologie de Lyon Institut universitaire de France Immunologie humaine, physiopathologie & immunothérapie Institut de biochimie et génétique cellulaires Centre méditerranéen de médecine moléculaire Universiteit Gent = Ghent University = Université de Gand Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 Centre de Recherche des Cordeliers Centre de Biologie Intégrative Unité de biologie Moléculaire, Cellulaire et du Développement Actions for OnCogenesis understanding and Target Identification in ONcology Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule
• Publié dans Biomolecules le 25/10/2020

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Résumé : Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated cell death still remain to be elucidated in specific cell subtypes and disease conditions, many predicted that research into cell death was inexorably reaching a plateau. However, this was not the case since the last decade saw a multitude of cell death modalities being described, while harnessing their therapeutic potential reached clinical use in certain cases. In line with keeping research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN). The research conducted by FCDRN is at the leading edge of emerging topics such as non-apoptotic functions of apoptotic effectors, paracrine effects of cell death, novel canonical and non-canonical mechanisms to induce apoptosis in cell death-resistant cancer cells or regulated forms of necrosis and the associated immunogenic response. Collectively, these various lines of research all emerged from the study of apoptosis and in the next few years will increase the mechanistic knowledge into regulated cell death and how to harness it for therapy.

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Fichiers liés : biomolecules-12-00901-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/06/2022
• Auteurs : Stéphane BretagneKarine SitbonM. Desnos-OllivierDea Garcia-HermosoValérie BruSophie CassaingLaurence MillonFlorent MorioJean-Pierre GangneuxLilia HasseineLoïc FavennecEstelle CateauEric BaillyMaxime MoniotJulie BonhommeNicole Desbois-NogardTaieb ChouakiAndré PaugamBernard BouteilleMarc PihetFrédéric DalleOdile EloyMilène SassoMagalie DemarPatricia Mariani-KurkdjianVincent RobertOlivier LortholaryFrançoise DromerThe French Mycoses Study GroupCéline DamianiHervé DupontJulien MaizelAnne TotetJean-Philippe BoucharaAnne Pauline BellangerAna BerceanuJean Christophe NavellouEmeline SchererPhilippe AbboudChristine AznarDenis BlanchetFélix DjossouSophie CayotCyril GarrousteOlivier LesensCécile MoluçonCéline NourrissonPhilippe PoirierÉloïse BaillyLouise BasmaciyanBouhemad BelaidMathieu BlotDenis CaillotPierre-Emmanuel CharlesJean-Pierre QuenotEmmanuelle AmazanEmilie BaubionAndré CabieCyrille ChabartierChristophe DelignyViolaine EmalOlivier FlechelleYves HatchuelYohann Le GovicHarold MerleCharline MiossecJean-Marie TurmelRuddy ValentinoMarie-Fleur DurieuxPascal TurlureVictor MercierMartine Gari-ToussaintKarine RissoLoïc SimonCedric BretonnièreDavid BoutoilleThomas GastinneKarim LakhalElise LaunayThierry LepoivrePierre PeterlinFanny RiallandPatrice Le PapeEtienne CanouiNaima DahaneSolène KerneisCécile AngebaultMarie-Elisabethh BougnouxNadia GuennouniFanny LanternierBennedicte NevenMehdi OualhaAnne ScemlaEmilie SitterléFelipe SuarezJulie ToubianaStéphane BonacorciAlexandre AlanioAnne BergeronBlandine DenisMaud Gits-MuselliSamia HamaneSophie TouratierChristine ChaumeilLilia MerabetJoelle ClaudéonElodie CurlierValérie GalantineJean Claude GalloisSamuel MarkowiczMuriel NicolasPascal MussonKinda SchepersAlida MinozaCatherine Kauffmann-LacroixHélène GuéganDamien CostaMarion DehaisGilles GargalaOdile BajoletFirouze BanisadrJoel CoussonChantal HimberlinAntoine HugueninDominique ToubasPierre FloriCaroline MahincHélène RaberinJulie DenisRaoul HerbrechtPaul-Michel MertesFehrat MezianiAlina-Marcela SabouFrancis SchneiderAnne-Isabelle BertozziPamela ChauvinEléna CharpentierOlivier CointaultClaire CottrelKaren DelavigneStanislas FaguerJudith FillauxEmilie GuemasXavier IriartLucie LelièvreJean RuizFrédéric BastidesAdélaïde ChesnayGuillaume DesoubeauxAudrey TherbyElisabeth ChachatyBertrand Gachot
• Organismes : Mycologie moléculaire - Molecular Mycology Hopital Saint-Louis [AP-HP] Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie moléculaire - Molecular Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie moléculaire - Molecular Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie moléculaire - Molecular Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Dynamique des interactions hôte pathogène Centre Hospitalier Universitaire de Toulouse Geroscience and rejuvenation research center Laboratoire Chrono-environnement (UMR 6249) Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Nice CHU Rouen Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Écologie et biologie des interactions [UMR 7267] Centre Hospitalier Régional Universitaire de Tours CHU Clermont-Ferrand CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] CHU Amiens-Picardie Hôpital Cochin [AP-HP] CHU Limoges SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Laboratoire de Parasitologie-Mycologie (CHU d'Angers) Infections Respiratoires Fongiques Procédés Alimentaires et Microbiologiques [Dijon] Centre Hospitalier de Versailles André Mignot Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Hôpital Robert Debré Paris Westerdijk Fungal Biodiversity Institute [Utrecht] Mycologie moléculaire - Molecular Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Service des Maladies infectieuses et tropicales [CHU Necker] Mycologie moléculaire - Molecular Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Simplification des soins chez les patients complexes - UR UPJV 7518 Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Laboratoire de Parasitologie-Mycologie [CHU Angers] Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Pathogenesis and Control of Chronic and Emerging Infections Hôpital Bretonneau Centre d’Etude des Pathologies Respiratoires [Tours]
• Publié dans mBio le 21/10/2020

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Résumé : The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools. IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.

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Fichiers liés : mbio.00920-22.pdf

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• Type de publi. :
• Date de publi. : 28/06/2022
• Auteurs : Philippe ColombanBurcu KirmiziJean-Baptiste ClaisMichele Gironda
• Organismes : De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies Laboratoire de Dynamique Interactions et Réactivité Laboratoire de Physique de la Matière Condensée Yildiz Technical University Musée du Louvre XGLab S.R.L – Bruker, Milan

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Résumé : Gilt-decorated porcelains of Joseph Coteau and Philippe Parpette, unifying metal and ceramic enamel techniques, had been produced from ~1770 to 1800 but this production was rare and poorly documented [1,2]. Enamelled decorations of these artefacts display gold foils (paillon in French) coated with lead-based transparent and opaque enamels fired on the porcelain glaze. Rare items were being produced at different factories (Sèvres Royal Factory, Duc d’Artois Factory) and it is reported that some copies were made during the 19th century. This study presents the first (non-destructive) Raman and pXRF study of four cups and two pairs of vases. In these artefacts, decorations made of enamelled gold foil were applied both on soft-paste (Parpette and Coteau production) and hard-paste (Coteau production) porcelain body. The analyses showed the differences in the glazing technology used. The bonding between the gold foil and the glaze was obtained by addition of arsenic and possibly some other fluxes (boron, bismuth?). The use of cassiterite opacifier seems to be characteristic of Coteau’s technique. [1] R. de Plinval de Guillebon, Un phénomène périodique: la mode du décor d’or appliqué et d’émail sur la porcelaine française (XVIIe-XIXe siècles), Rev. Soc. Amis Sèvres 1 (1992) 7-22. [2] T. Preaud, Sèvres enamelled porcelain: Eight dies (and a quarrel) rediscovered, The Burlington Magazine 128 [999] (1986) 391-397.

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Fichiers liés : INART 2022_Coteau.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/06/2022
• Auteurs : Patrick MagetPierre ManasRémi DumontClemente AngioniJean François ArtaudClarisse BourdelleLaurent ColasPascal DevynckFajardo D.Nicolas FedorczakMarc GonicheJulien HillairetPhilippe HuynhJorge MoralesValeria OstuniDidier Vezinet
• Organismes : Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Max-Planck-Institut für Plasmaphysik [Garching] Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Max-Planck-Institut für Plasmaphysik [Garching] Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique

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Fichiers liés : EPS2022_Maget_v4.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/06/2022
• Auteurs : Romain BasalgèteDaniela Torres‐díazRémi DupuyGéraldine FéraudClaire RomanzinXavier MichautJ. MichoudL. PhilippeAmiaud LionelA LafosseJean-Hugues FillionMathieu Bertin
• Organismes : Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Institut des Sciences Moléculaires d'Orsay Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Laboratoire de Chimie Physique - Matière et Rayonnement Fritz-Haber-Institut der Max-Planck-Gesellschaft Physique des interactions ioniques et moléculaires Institut de Chimie Physique Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Institut des Sciences Moléculaires d'Orsay Institut des Sciences Moléculaires d'Orsay Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres

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Résumé : The most recent observations of small organic species in the gas phase of the coldest regions of space imply the existence of efficient non-thermal desorption phenomena, central to maintain a sufficient budget of molecules in the gas which should otherwise be depleted by freezing out on interstellar dust grains. This last decade, laboratory experiments have mainly focused on the desorption induced by vacuum UV photons, cosmic rays and recombinative chemistry. However, processes induced by photons of higher energy, despite being present in star and planet formation regions, were largely unknown and neglected in models, until recently. Indeed, X-ray induced desorption from molecular ices has received a peculiar attention in th e past few years 4,5,6. This process, also known as X-ray photodesorption, should participate to the physical and chemical evolution of different astrophysical environments where the X-ray field is important, such as protoplanetary disks, comets and icy moons and planets 7. Recent investigations 1,2,3 have revealed, in the soft X-ray range, an indirect desorption process that induces the desorption of molecules at photon energy where they are not expected to desorb. This indirect mechanism has major implications and still needs to be fully understood. In this context, X-ray photodesorption experiments were conducted at the SOLEIL synchrotron facility in France by coupling the Ultrahigh Vacuum SPICES setup to the SEXTANTS beamline, in order to measure desorption yields by mass spectrometry, but also to shed light on the involved mechanisms. Desorption of simple molecules such as 13 CO and 15 N2 was studied as a simple case in order to characterize the indirect desorption process. Resonant 1s core excitation near the N (~400 eV) or O (~500 eV) K-edge, reachable thanks to tunable and high spectral resolution X-rays from the synchrotron beamline, allows to selectively photo-excite 15 N2 or 13 CO to trigger desorption from ices containing these molecules. This first set of experiments allows to discuss the desorption mechanisms and their properties with respect to the energy transport in the ice. Finally, X-ray photodesorption is studied for methanol CH3OH and other small organic molecules in order to explore the desorption process for more complex molecules, especially relevant for astrochemistry.

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