Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 18/05/2022
• Auteurs : Louis ThieryXavier CarleBenoit TestudGrégoire BoulouisMathieu Di BisceglieFarouk TradiAnthony ReyrePierre LehmannPhilippe Dory-LautrecJan-Patrick StellmannNadine GirardHerve BrunelJean-François Hak
• Organismes : Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
• Publié dans Journal of Neurointerventional Surgery le 26/10/2020

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Résumé : Background Balloon-assisted mechanical angioplasty for cerebral vasospasm following aneurysmal subarachnoid hemorrhage (aSAH) has a number of limitations, including transient occlusion of the spastic blood vessel. Comaneci is an FDA-approved device for temporary coil embolization assistance which has recently also been approved for the treatment of distal symptomatic refractory vasospasm. We aimed to report the feasibility, efficacy and safety of our experience with Comaneci angioplasty for refractory distal vasospasm (up to the second segment of the cerebral arteries) following aSAH. Methods This is a retrospective analysis of a prospective series of 18 patients included between April 2019 and June 2021 with aSAH and symptomatic vasospasm refractory to medical therapy, who were treated using Comaneci-17-asssisted mechanical distal angioplasty. Immediate angiographic results, procedure-related complications, and clinical outcomes were assessed. Inter-rater reliability of the scores was determined using the intraclass correlation coefficient. Results Comaneci-assisted distal angioplasty was performed in 18 patients, corresponding to 31 target arteries. All distal anterior segments were easily accessible with the Comaneci-17 device. Vasospasm improvement after Comaneci mechanical angioplasty was seen in 22 distal arteries (71%) (weighted Cohen’s kappa (κ w ) 0.73, 95% CI 0.69 to 0.93). Vasospasm recurrence occurred in three patients (16.67%) and delayed cerebral infarction in three patients (16.67%), with a mean±SD delay between onset of symptoms and imaging follow-up (MRI/CT) of 32.61±8.93 days (κ w 0.98, 95% CI 0.88 to 1). Conclusion This initial experience suggests that distal mechanical angioplasty performed with the Comaneci-17 device for refractory vasospasm following aSAH seems to be safe, with good feasibility and efficacy.

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• Type de publi. : Article dans une revue
• Date de publi. : 17/05/2022
• Auteurs : Sonia Etenna Lekana-DoukiNadine N'DilimabakaAnthony LevasseurPhilippe ColsonJulia Cyrielle AndekoOrnella Zong MinkoOctavie Banga Mve-EllaPierre-Edouard FournierChristian DevauxBertrand Mve OndoFalone Larissa AkombiLaurianne Yacka Mouele BoloAudrey Michel Ngonga DikongoAbdoulaye DianéArsène Mabika MabikaJenny Francine MathouetCresh DzemboNick Chenis AtigaAnicet Mouity MatoumbaNal Kennedy NdjangangoyeLudivine BréchardMarielle Bedotto-BuffetJoa Braithe Mangombi PambouMarisca Kandet YattaraElvire Anita Mbongo NkamaArmel Mintsa NdongAyola Akim AdegnikaDidier RaoultFlorence FenollarJean-Bernard Lekana-Douki
• Organismes : Centre International de Recherches Médicales de Franceville Centre International de Recherches Médicales de Franceville Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Centre National de la Recherche Scientifique Centre International de Recherches Médicales de Franceville Centre International de Recherches Médicales de Franceville Centre International de Recherches Médicales de Franceville Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Centre International de Recherches Médicales de Franceville
• Publié dans Frontiers in Medicine le 01/11/2020

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Résumé : Since the onset of the COVID-19 pandemic, the SARS-CoV-2 viral dynamics in Africa have been less documented than on other continents. In Gabon, a Central African country, a total number of 37,511 cases of COVID-19 and 281 deaths have been reported as of December 8, 2021. After the first COVID-19 case was reported on March 12, 2020, in the capital Libreville, the country experienced two successive waves. The first one, occurred in March 2020 to August 2020, and the second one in January 2021 to May 2021. The third wave began in September 2021 and ended in November 2021. In order to reduce the data gap regarding the dynamics of SARS-CoV-2 in Central Africa, we performed a retrospective genotyping study using 1,006 samples collected from COVID-19 patients in Gabon from 2020 to 2021. Using SARS-CoV-2 variant screening by Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) and whole genome sequencing (WGS), we genotyped 809 SARS-CoV-2 samples through qRT-PCR and identified to generated 291 new genomes. It allowed us to describe specific mutations and changes in the SARS-CoV-2 variants in Gabon. The qRT-PCR screening of 809 positive samples from March 2020 to September 2021 showed that 119 SARS-CoV-2 samples (14.7%) were classified as VOC Alpha (Pangolin lineage B.1.1.7), one (0.1%) was a VOC Beta (B.1.351), and 198 (24.5 %) were VOC Delta (B.1.617.2), while 491 samples (60.7%) remained negative for the variants sought. The B1.1 variant was predominant during the first wave while the VOC Alpha dominated the second wave. The B1.617.2 Delta variant is currently the dominant variant of the third wave. Similarly, the analysis of the 291 genome sequences indicated that the dominant variant during the first wave was lineage B.1.1, while the dominant variants of the second wave were lineages B.1.1.7 (50.6%) and B.1.1.318 (36.4%). The third wave started with the circulation of the Delta variant (B.1.617). Finally, we compared these results to the SARS-CoV-2 sequences reported in other African, European, American and Asian countries. Sequences of Gabonese SARS-CoV-2 strains presented the highest similarities with those of France, Belgium and neighboring countries of Central Africa, as well as West Africa.

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Fichiers liés : fmed-09-877391.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/05/2022
• Auteurs : Antoine MiniussiLaurent ArtolaFabrice BoustPablo CaronChristophe CoudrainDidier FalguèreOlivier GazzanoGuillaume GourvesKevin GrosselJean GuerardPierre-Emmanuel HaenslerFrançois IssacJulien JaeckVincent LebatVincent MagetJean-Charles Matéo-VelezDenis PackanYoann PaichardPhilippe PerraultHuy-Khang PhanArnaud PulignyWilfrid QuenumVéronique RannouBernard RosierLaurent Rousset-RouvièreJ.-F. SauvagePierre SimoneauSophie Thétas
• Organismes : DTIS, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université de Toulouse [Toulouse] DEMR, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DTIS, ONERA, Université de Toulouse [Toulouse] DEMR, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université Paris Saclay [Châtillon] DTIS, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université Paris Saclay [Châtillon] DPHY, ONERA, Université de Toulouse [Toulouse] DPHY, ONERA, Université de Toulouse [Toulouse] DPHY, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université de Toulouse [Toulouse] DEMR, ONERA, Université Paris Saclay [Palaiseau] ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA [Salon-de-Provence] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau]

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Résumé : ONERA has been working for the past few years in developing space systems oriented toward Cubesat technology. In collaboration with industrials, universities and research labs, ONERA is working on several cubesat missions with scientific and technological goals. Those include ionosphere study, radiation belts monitoring, earth observation and ESD mitigation systems. To feed these activities our teams also work on technological bricks such as deployable telescope, optical freeform designs and rad-hard digital core. Finally, unique test benches to validate designs sustaining the space environment (EMC, radiation, electrical propulsion, TVAC) complete our equipment. Such range of activities requires organization and strategy to provide necessary support to our teams and partners in order to complete our missions. The ONSATLab is dedicated to this purpose.

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Fichiers liés : DTIS22139.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/05/2022
• Auteurs : Florence LeclercqPierre-Alain MeunierThomas GandetJean-Christophe MaciaDelphine DelsenyPhilippe GaudardMarc MouradLaurent SchmutzPierre RobertFrançois RoubilleGuillaume CaylaMariama Akodad
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : Increasing operators’ experience and improvement of the technique have resulted in a drastic reduction in complications following transcatheter aortic valve replacement (TAVR) in patients with lower surgical risk. In parallel, the procedure was considerably simplified, with a routine default approach including local anesthesia in the catheterization laboratory, percutaneous femoral approach, radial artery as the secondary access, prosthesis implantation without predilatation, left ventricle wire pacing and early discharge. Thus, the “simplified” TAVR adopted in most centers nowadays is a real revolution of the technique. However, simplified TAVR must be accompanied upstream by a rigorous selection of patients who can benefit from a minimalist procedure in order to guarantee its safety. The minimalist strategy must not become dogmatic and careful pre-, per- and post-procedural evaluation of patients with well-defined protocols guarantee optimal care following TAVR. This review aims to evaluate the benefits and limits of the simplified TAVR procedure in a current and future vision.

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Fichiers liés : jcm-11-02793.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/05/2022
• Auteurs : Martin DresMarcelo Gama de AbreuHamid MerdjiHolger Müller-RedetzkyDominic DellwegWinfried RanderathSatar MortazaBoris JungChristian BruellsOnnen MoererMartin ScharffenbergSamir JaberSébastien BessetThomas BitterArnim GeiseAlexander HeineMaximilian MalfertheinerAndreas KortgenJonathan BenzaquenTeresa NelsonAlexander UhrigOlaf MoenigFerhat MezianiAlexandre DemouleThomas SimilowskiFrançois BelonclePierre-Yves OlivierMarie LemerlePierre AsfarAlain MercatKatharina BöllingerMarc GiesaCarmen GarciaTill JacobiNikolas LambirisFelix MachleidPanagiotis PergantisBastian GrubeDamien RouxSantiago Freita RamosNoemie ZucmanLouis Marie DumontLaura FedericiMarc AmourettiJean-Damien RicardDidier DreyfussJakob WittensteinAndreas GüldnerMax RagallerPeter SpiethChristopher UhligLars-Olav HarnischFrank BloosDaniel Thomas-RüddelGérald ChanquesMathieu CapdevilaYassir AarabFanny GarnierVincent BrunotKada KloucheValérie MoulairePhilippe CorneFernand MaconeFrançois DurandCharles-Hugo MarquetteJulie DelemazureJulien MayauxElise MorawiecAlexandra MonnierHassene RahmaniLouise-Marie JandeauxAntoine StuderJulie HelmsRaphaël Clere-Jehl
• Organismes : Neurophysiologie Respiratoire Expérimentale et Clinique
• Publié dans American Journal of Respiratory and Critical Care Medicine le 26/10/2020

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• Type de publi. :
• Date de publi. : 13/05/2022
• Auteurs : Pierre-Yves GomezJean-Philippe Denis
• Organismes : EMLyon Business School Université Paris-Saclay Réseaux Innovation Territoires et Mondialisation

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Résumé : Xerfi Canla a reçu Pierre-Yves Gomez, professeur, IFGE, em lyon business school, pour parler du capitalisme. Une interview menée par Jean-Philippe Denis.

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Fichiers liés : Le_capitalisme_en_Que_Sais_Je_Pierre_Yves_Gomez_.mp4

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• Type de publi. : Article dans une revue
• Date de publi. : 10/05/2022
• Auteurs : Lou BernardAlia JouharaEric QuarezEric QuarezS. Le CaërPierre Tran-VanStéven RenaultPhilippe Poizot
• Organismes : Institut des Matériaux de Nantes Jean Rouxel Technocentre Renault [Guyancourt] Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire Technocentre Renault [Guyancourt] Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel
• Publié dans Inorganics le 25/10/2020

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Résumé : Organic electrode materials offer obvious opportunities to promote cost-effective and environmentally friendly rechargeable batteries. Over the last decade, tremendous progress has been made thanks to the use of molecular engineering focused on the tailoring of redox-active organic moieties. However, the electrochemical performance of organic host structures relies also on the crystal packing, like the inorganic counterparts, which calls for further efforts in terms of crystal chemistry to make a robust redox-active organic center electrochemically efficient in the solid state. Following our ongoing research aiming at elaborating lithiated organic cathode materials, we report herein on the impact of polymorphism on the electrochemical behavior of dilithium (2,3-dilithium-oxy-)terephthalate vs. Li. Having isolated dilithium (3-hydroxy-2-lithium-oxy)terephthalate through an incomplete acid-base neutralization reaction, its subsequent thermally induced decarboxylation mechanism led to the formation of a new polymorph of dilithium (2,3-dilithium-oxy-)terephthalate referred to as Li4-o-DHT (β-phase). This new phase is able to operate at 3.1 V vs. Li+/Li, which corresponds to a positive potential shift of +250 mV compared to the other polymorph formerly reported. Nevertheless, the overall electrochemical process characterized by a sluggish biphasic transition is impeded by a large polarization value limiting the recovered capacity upon cycling.

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Fichiers liés : inorganics-10-00062-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/05/2022
• Auteurs : Cyril OberlinStéphane PatryCéline Pochat-BohatierMirna BechelanyJean‐pierre HabasPhilippe Miele
• Organismes : Institut Européen des membranes Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Européen des membranes Safran Advanced Turbine Airfoils, Colombes, France Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Européen des membranes
• Publié dans Journal of Applied Polymer Science le 31/10/2020

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Résumé : This work investigates the suitability of epoxy resins for possible use in an industrial gelcasting process. Two different formulations are studied using complementary experimental techniques. Both reactive formulations are based on a difunctional epoxy prepolymer (aliphatic BDGE or aromatic RDGE) mixed with a polyamine hardener (TEPA). The combination of analytical chemistry (NMR and FTIR spectroscopy) and calorimetric measurements (DSC) are used to determine the optimal epoxy/amine ratio for each reactive formulation. The gelation and vitrification times are investigated by dynamic rheometry through kinetic analyses over a large range of fixed temperature. It is found that the RDGE-TEPA mixture is more reactive than BDGE-TEPA with shorter curing starting times. The thermomechanical analyses performed on both optimized formulations show that the RDGE-TEPA material presents better performances after curing (Tg close to 80°C) than the BDGE-TEPA system (Tg lower than ambient temperature). Then, the effects of the cooling cycle on the thermomechanical profile of each polymer are investigated. The RDGE-TEPA formulation is found to be much more subject to the formation of internal stresses created during the cross-linking and cooling step than the BDGE-TEPA material. Considering all these criteria, the BDGE-TEPA system is ultimately more suitable for the gelcasting process than RDGE-TEPA.

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• Type de publi. : Article dans une revue
• Date de publi. : 04/05/2022
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoHanspeter NaegeliFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneAntonio FernandezDafni Maria KagkliAleksandra LewandowskaTommaso RaffaelloFranz Streissl
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Following the submission of application EFSA-GMO-RX-020 under Regulation (EC) No 1829/2003 from BASF Agricultural Solutions Seed US LLC, the Panel on Genetically Modified Organisms of the EFSA was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide-tolerant genetically modified soybean A5547-127, for food and feed uses, excluding cultivation within the European Union. The data received in the context of this renewal application contained post-market environmental monitoring reports, a systematic search and evaluation of literature, updated bioinformatic analyses and additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. The GMO Panel concludes that there is no evidence in renewal application EFSA-GMO-RX-020 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on soybean A5547-127.

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Fichiers liés : EFSA Journal - 2022 - - Assessment of genetically modified soybean A5547‐127 for renewal authorisation under Regulation .pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/05/2022
• Auteurs : Dzovinar KévonianPhilippe RygielSimon BurrowsJennifer EdmondJo GuldiJean-Pierre Bat
• Organismes : Histoire, Territoires et Mémoires Institut des Sciences sociales du Politique LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 École normale supérieure de Lyon Western Sydney University Trinity College Dublin Southern Methodist University [Dallas, TX, USA] Institut des Mondes Africains
• Publié dans Monde(s). Histoire, Espaces, Relations le 22/10/2020

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Résumé : The present text was produced after a year and a half of the world pandemic, lockdowns, and strange and awkward educational sequences. Remote access to sources and materials that make possible the production and conveyance of a global history – a vital, shared necessity in today’s world – transformed technical issues discussed among specialists – i.e., burning issues from the news and issues of evidence – into the theme of worldwide conversation in the summer of 2021. Since during this global crisis, historians have revealed themselves to be dependent on complex and instrumented infrastructures, it seemed natural for us to open up the discussion to colleagues who had not only used digital resources, but who had also participated, in various capacities, in the development of the platforms, tools and standards that make up the historian’s digital world. In this complex space, each person’s experience; their inclusion in academic settings that rarely adhere to the same logic; their field of expertise; the place they hold within their institutions; and their functional role all orient their perspectives.

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