Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Nicolas MassartAlexandre MansourJames T RossCaroline PiauJean-Philippe VerhoyePierre TattevinNicolas Nesseler
• Organismes : Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] Service d'Anesthésie Réanimation [Rennes] Service d'Anesthésie Réanimation [Rennes] University of California [San Francisco] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Service de chirurgie thoracique cardiaque et vasculaire [Rennes] = Thoracic and Cardiovascular Surgery [Rennes] Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes] Service d'Anesthésie Réanimation [Rennes] Nutrition, Métabolismes et Cancer Centre d'Investigation Clinique [Rennes]
• Publié dans Journal of Thoracic and Cardiovascular Surgery le 27/10/2020

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Résumé : Purpose: Hospital-acquired infections have been associated with significant morbidity and mortality in critically ill surgical patients. However, little is known about mortality due to hospital-acquired infections in cardiac surgery.Methods: We conducted a retrospective analysis of prospectively collected data from the cardiac surgery unit of a university hospital. All patients who underwent cardiac surgery over a 7-year period were included. Patients with hospital-acquired infections were matched 1:1 with patients with nonhospital-acquired infections based on risk factors for hospital-acquired infections and death after cardiac surgery using propensity score matching. We performed a competitive risk analysis to study the mortality fraction due to hospital-acquired infections.Results: Of 8853 patients who underwent cardiac surgery, 370 (4.2%) developed 500 postoperative infections (incidence density rate 4.2 hospital-acquired infections per 1000 patient-days). Crude hospital mortality was significantly higher in patients with hospital-acquired infections than in matched patients who did not develop hospital-acquired infections, 15.4% and 5.7%, respectively (P < .001). The in-hospital mortality fraction due to hospital-acquired infections in our cohort was 17.1% (12.3%-22.8%). Pseudomonas aeruginosa infection (hazard ratio, 2.09; 95% confidence interval, 1.23-3.49; P = .005), bloodstream infection (hazard ratio, 2.08; 95% confidence interval, 1.19-3.63; P = .010), and pneumonia (hazard ratio, 1.68; 95% confidence interval, 1.02-2.77; P = .04) were each independently associated with increased hospital mortality.Conclusions: Although hospital-acquired infections are relatively uncommon after cardiac surgery (4.2%), these infections have a major impact on postoperative mortality (attributable mortality fraction, 17.1%).

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Fichiers liés : Massart et al-2020-Mortality attributable to hospital-acquired infection.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Emilie BurelPhilippe ColsonJean-Christophe LagierAnthony LevasseurMarielle BedottoPhilippe Lavrard-MeyerPierre-Edouard FournierBernard La ScolaDidier Raoult
• Organismes : Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Aix-Marseille Université - École de médecine Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Viruses le 01/11/2020

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Résumé : Genetic recombination is a major evolutionary mechanism among RNA viruses, and it is common in coronaviruses, including those infecting humans. A few SARS-CoV-2 recombinants have been reported to date whose genome harbored combinations of mutations from different mutants or variants, but only a single patient’s sample was analyzed, and the virus was not isolated. Here, we report the gradual emergence of a hybrid genome of B.1.160 and Alpha variants in a lymphoma patient chronically infected for 14 months, and we isolated the recombinant virus. The hybrid genome was obtained by next-generation sequencing, and the recombination sites were confirmed by PCR. This consisted of a parental B.1.160 backbone interspersed with two fragments, including the spike gene, from an Alpha variant. An analysis of seven sequential samples from the patient decoded the recombination steps, including the initial infection with a B.1.160 variant, then a concurrent infection with this variant and an Alpha variant, the generation of hybrid genomes, and eventually the emergence of a predominant recombinant virus isolated at the end of the patient’s follow-up. This case exemplifies the recombination process of SARS-CoV-2 in real life, and it calls for intensifying the genomic surveillance in patients coinfected with different SARS-CoV-2 variants, and more generally with several RNA viruses, as this may lead to the appearance of new viruses.

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Fichiers liés : viruses-14-01266-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiAntonio Fernandez DumontSilvia FedericiDafni Maria KagkliAnna LanzoniNikoletta PapadopoulouTommaso Raffaello
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : The GMO Panel has previously assessed genetically modified (GM) cotton DAS-24236-5 9 DAS-21Ø23-5 and concluded that it is as safe as its conventional counterpart and other appropriate comparators with respect to potential effects on human and animal health and the environment in the context of its intended uses. On 17 November 2020, the European Commission requested EFSA to evaluate new DNA sequence information and updated bioinformatics data for cotton DAS-24236-5 9 DAS-21Ø23-5 and to indicate whether the conclusions of the GMO Panel on the previously assessed cotton DAS-24236-5 9 DAS-21Ø23-5 remain valid. The new sequence data of DAS-24236-5 showed the change of one nucleotide that results in one amino acid substitution, in the newly expressed Cry1F (synpro_L620Q) compared to the sequence originally reported. The GMO Panel concludes that this amino acid substitution in the protein is a mutation. Nonetheless with the exception of the bioinformatics analysis, the studies performed for the risk assessment of Cry1F in cotton DAS-24236-5 9 DAS-21Ø23-5 remain valid. In addition, the new sequencing data showed a change in one nucleotide in the 5 0 flanking region of DAS-21Ø23-5 compared to the original sequence reported on the stack cotton DAS-24236-5 9 DAS-21Ø23-5. The bioinformatic analyses of the newly sequenced DAS-21Ø23-5 event in the stack DAS-24236-5 9 DAS-21Ø23-5 shows that the nucleotide difference is in the 5 0 flanking region outside the ORFs that span the 5 0 junction and is therefore not considered further in the safety assessment. Based on the information provided, the GMO Panel concludes that the corrected sequence does not give rise to any safety concerns, and therefore, the original risk assessment of cotton DAS-24236-5 9 DAS-21Ø23-5 remains valid.

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Fichiers liés : EFSA Journal - 2022 - - Assessment of new sequencing information for genetically modified cotton DAS‐24236‐5 DAS‐21 23‐5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : François-Xavier ChauvièreDenis BlantMyriam Boudadi-MaligneFrédéric BrenetJean‐christophe CastelDeak JuditBastien JakobMarc LuetscherJulien SpielmannValéry UldryEstelle VuilleumierSonia WüthrichPhilippe Zuppinger
• Organismes : Office du patrimoine et de l’archéologie du canton de Neuchâtel, section archéologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Muséum d'Histoire Naturelle de Genève
• Publié dans Cavernes le 18/11/2022

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Résumé : La grotte des Plaints (Couvet) est, avec celle de Cotencher (Rochefort), l’autre cavité neuchâteloise à avoir livré les vestiges d’occupations humaines attribués au Paléolithique moyen. Les nouvelles fouilles entreprises sur ce site en 2021 sont significatives du tournant opéré par l’archéologie cantonale depuis dix ans. Elles prennent place au sein d’un projet interdisciplinaire de valorisation et d’étude d’une caverne au potentiel scientifique très important, juste effleuré par les travaux qui y ont été menés dans les années 1950-1960

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Samir JaberMarc GarnierKarim AsehnouneFanny BounesLouis BuscailJean-Baptiste ChevauxClaire Dahyot-FizelierLucie DarrivereMatthieu JabaudonOlivier Joannes-BoyauYoann LauneyEric LevesquePhilippe LevyPhilippe MontraversLaurent MullerThomas RimmeléClaire RogerCéline Savoye-ColletPhilippe SeguinJean-Pierre TasuRonan ThibaultGeoffroy VanbiervlietEmmanuel WeissAudrey de Jong
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Institut des Maladies Métaboliques et Casdiovasculaires Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Physiopathologie et Epidémiologie des Maladies Respiratoires Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques / Pathophysiology of Injury-induced Immunosuppression Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Centre de recherche sur l'Inflammation Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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Résumé : Objective: To provide guidelines for the management of the intensive care patient with severe acute pancreatitis.Design: A consensus committee of 22 experts was convened. A formal conflict-of-interest (COI) policy was developed at the beginning of the process and enforced throughout. The entire guideline construction process was conducted independently of any industrial funding (i.e. pharmaceutical, medical devices). The authors were required to follow the rules of the Grading of Recommendations Assessment, Development and Evaluation (GRADE®) system to guide assessment of quality of evidence. The potential drawbacks of making strong recommendations in the presence of low-quality evidence were emphasised.Methods: The most recent SFAR and SNFGE guidelines on the management of the patient with severe pancreatitis were published in 2001. The literature now is sufficient for an update. The committee studied 14 questions within 3 fields. Each question was formulated in a PICO (Patients Intervention Comparison Outcome) format and the relevant evidence profiles were produced. The literature review and recommendations were made according to the GRADE® methodology.Results: The experts' synthesis work and their application of the GRADE® method resulted in 24 recommendations. Among the formalised recommendations, 8 have high levels of evidence (GRADE 1+/-) and 12 have moderate levels of evidence (GRADE 2+/-). For 4 recommendations, the GRADE method could not be applied, resulting in expert opinions. Four questions did not find any response in the literature. After one round of scoring, strong agreement was reached for all the recommendations.Conclusions: There was strong agreement among experts for 24 recommendations to improve practices for the management of intensive care patients with severe acute pancreatitis.

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Fichiers liés : 2022 Jaber et al., Guidelines for.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Florence AderMaude Bouscambert-DuchampMaya HitesNathan Peiffer-SmadjaFrance MentréCharles BurdetJérôme AboabFlorence AderHafid Ait-OufellaAntoine AltdorferClaire AndréjakPascal AndreuLaurent ArgaudFirouzé Bani-SadrDrifa BelhadiLeila BelkhirFrançois BenezitMarc BernaMathieu BlotElisabeth Botelho-NeversLila BouadmaOlivier BouchaudDavid BougonKevin BouillerFanny Bounes-VardonMaude Bouscambert-DuchampDavid BoutoilleAlexandre BoyerSandra BrazCédric BruelCharles BurdetAndré CabiéEmmanuel CanetCharles CazanaveCyrille ChabartierCatherine ChirouzeRaphaël Clere-JehlDominique CostagliolaSandrine Couffin-CadièrguesJohan CourjonFlora CrockettFrançois DanionAline DechanetAgathe DelboveJean DellamonicaChristelle DelmasAlpha DialloFélix DjossouClément DubostAlexandre DuvignaudAlexander EgleOlivier EpaulardLoïc EpelboinHélène EsperouMurielle FartoukhKarine FaureEmmanuel FaureJoao-Miguel Ferreira RibeiroTristan FerryCécile FickoSamy FigueiredoClaire FougerouVincent FraipontBenjamin GaboritRostane GaciAmandine Gagneux-BrunonSébastien GallienDenis GarotAlexandre GaymardGuillaume GeriSébastien GibotFrançois GoehringerMarie GousseffRichard GreilDidier GrusonJérémie GuedjYves HansmannOlivier HinschbergerMaya HitesStéphane JaureguiberryVanessa JeanmichelMichael JoannidisSolen KernéisAntoine KimmounKada KloucheMarie LachâtreKarine LacombeFabrice LaineBernd LamprechtJ.P. LanoixOdile LaunayBruno LaviolleMinh-Patrick LêVincent Le MoingJérôme Le PavecYves Le TulzoPaul Le TurnierDavid LebeauxBenjamin LefevreSylvie LeroyFrançois-Xavier LescureHenry LessireBenjamin LeveauBruno LinaPaul LoubetAlain MakinsonDenis MalvyCharles-Hugo MarquetteGuillaume Martin-BlondelMartin MartinotJulien MayauxArmand Mekontso-DessapFrance MentréNoémie MercierFerhat MezianiJean-Paul MiraJean-Michel MolinaXavier MonnetJoy MootienBruno MourvillierBruno MourvilliersMarlène Murris-EspinJean-Christophe NavellouMarion NoretSaad NseirWalid OulehriJosé-Artur PaivaNathan Peiffer-SmadjaThomas PerpointGilles PeytavinGilles PialouxBenoît PilmisVincent PiriouLionel PirothJulien PoissyValérie PourcherJean-Pierre QuenotFrançois RaffiJean ReignierJean ReuterMatthieu RevestJean-Christophe RichardBéatrice Riu-PoulencCéline RobertPierre-Alexandre RogerClaire RogerRoberto Roncon-AlbuquerqueElisabeth RouveixYvon RuchNadia SaidaniJuliette SaillardNaomi SayreEric SennevilleAlbert SottoThérèse StaubFrancois StefanCharles TacquardNicolas TerziJulien TextorisGuillaume ThieryJean-François TimsitViolaine TolsmaSarah TubianaJean-Marie TurmelFlorent ValourFanny Vardon-BounesPriyanka VelouGil VerscheldenFlorent WalletGuilhem WattecampsYazdan YazdanpanahYoann Zerbib
• Organismes : Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Centre National de Reference des virus des Infections Respiratoires France Sud [HCL, Lyon] Centre International de Recherche en Infectiologie Centre International de Recherche en Infectiologie Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis Infection, Anti-microbiens, Modélisation, Evolution Services de Maladies Infectieuses et Tropicales [CHU Bichat] Imperial College London Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] Dynamic Microbiology - EA 7380
• Publié dans The Lancet Infectious Diseases le 29/10/2020

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Résumé : No abstract available

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Fichiers liés : 2022 Ader et al., Final results.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Romain DonneMaëva Saroul-AinamaPierre CordierAdel HammouteneChristelle KaboreMira StadlerIvan NemazanyyIsabelle Galy-FaurouxMounia HerragTobias RiedlMarie Chansel-da CruzStefano CarusoStéphanie BonnafousRupert ÖllingerRoland RadKristian UngerAlbert TranJean-Pierre CoutyPhilippe GualValérie ParadisSéverine Celton-MorizurMathias HeikenwalderPatrick RevyChantal Desdouets
• Organismes : Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de recherche sur l'Inflammation Centre de Recherche des Cordeliers German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Structure Fédérative de Recherche Necker Centre de Recherche des Cordeliers Imagine - Institut des maladies génétiques (IHU) German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Imagine - Institut des maladies génétiques (IHU) Centre de Recherche des Cordeliers Centre méditerranéen de médecine moléculaire Klinikum rechts der Isar Klinikum rechts der Isar Helmholtz Zentrum München = German Research Center for Environmental Health Centre méditerranéen de médecine moléculaire Centre de Recherche des Cordeliers Centre méditerranéen de médecine moléculaire Centre de recherche sur l'Inflammation Hôpital Beaujon [AP-HP] Centre de Recherche des Cordeliers German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Imagine - Institut des maladies génétiques (IHU) Centre de Recherche des Cordeliers
• Publié dans Developmental Cell le 31/10/2020

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Résumé : Non-alcoholic steatotic liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD has a major effect on the intrinsic proliferative properties of hepatocytes. Here, we investigated the mechanisms underlying the activation of DNA damage response during NAFLD. Proliferating mouse NAFLD hepatocytes harbor replication stress (RS) with an alteration of the replication fork's speed and activation of ATR pathway, which is sufficient to cause DNA breaks. Nucleotide pool imbalance occurring during NAFLD is the key driver of RS. Remarkably, DNA lesions drive cGAS/STING pathway activation, a major component of cells' intrinsic immune response. The translational significance of this study was reiterated by showing that lipid overload in proliferating HepaRG was sufficient to induce RS and nucleotide pool imbalance. Moreover, livers from NAFLD patients displayed nucleotide pathway deregulation and cGAS/STING gene alteration. Altogether, our findings shed light on the mechanisms by which damaged NAFLD hepatocytes might promote disease progression.

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Fichiers liés : Donne et al., Dev Cell.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Ronan ScanffDavid NéronPierre LadevèzePhilippe BarabinotFrédéric CugnonJean-Pierre Delsemme
• Organismes : Siemens Industry Software SAS [Châtillon] Laboratoire de Mécanique Paris-Saclay Laboratoire de Mécanique Paris-Saclay Laboratoire de Mécanique Paris-Saclay Siemens Industry Software SAS [Châtillon] Siemens Industry Software N.V. Siemens Industry Software N.V.
• Publié dans Computer Methods in Applied Mechanics and Engineering le 30/10/2020

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Résumé : A weakly-invasive version of the LATIN-PGD method is introduced to compute reduced-order models in solid mechanics for time-dependent non-linear parametrized problems under quasi-static assumption. Its main interest is to be easily implemented in any general-purpose industrial finite element software while taking advantage of all facilities offered, including the ability to handle any kind of non-linearities. This way of proceeding provides unified tools – for the construction of reduced-order models in non-linear context – all integrated in one certified product in consistency with the purpose of having end-to-end processes. Possibilities of our approach are illustrated thanks to the first implementation conducted within Simcenter Samcef TM software developed by Siemens Digital Industries Software without ever redeveloping any non-linear part of the software. Finally, interesting performance gains are highlighted on a non-linear time-dependent test-case involving some parameters.

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Fichiers liés : Scanff2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Laurène TardieuGillian DivardOlivier LortholaryAnne ScemlaÉric RondeauIsabelle AccoceberryRémi AgbononAlexandre AlanioAdela AngoulvantLaetitia AlbanoPhilippe AttiasAnne Pauline BellangerDominique BertrandJulie BonhommeFrançoise BotterelNicolas BouvierMatthias BüchlerTaieb ChouakiThomas CrépinMarie-Fleur DurieuxGuillaume DesoubeauxGary DoppeltLoïc FavennecArnaud FekkarOphélie FourdinierMarie FrimatJean-Pierre GangneuxClaire GarandeauLilia HasseineChristophe HennequinXavier IriartNassim KamarHannah KaminskiRaphael KormannLaurence LachaudChristophe LegendreMoglie Le QuintrecJordan LeroyCharlène LeviMarie MachouartDavid MarxJean MenottiValérie MoalFlorent MorioNatacha MrozekMuriel NicolasPhilippe PoirierMarie-Noelle PeraldiBenjamin PoussotStéphane RanqueJean-Philippe RerolleBoualem SendidRenaud SnanoudjJérôme TourretMarc VasseCécile VigneauOdile VillardLaurent MesnardFanny LanternierCédric Rafat
• Organismes : CHU Tenon [AP-HP] Paris-Centre de Recherche Cardiovasculaire Service Néphrologie et transplantation rénale Adultes [CHU Necker] Centre d'infectiologie Necker-Pasteur [CHU Necker] Mycologie moléculaire - Molecular Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Génomique évolutive, modélisation et santé Service Néphrologie et transplantation rénale Adultes [CHU Necker] CHU Tenon [AP-HP] Hôpital Pellegrin CHU Tenon [AP-HP] Laboratoire de Parasitologie-Mycologie [CHU Saint Louis, Paris] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] CHU Nice [Cimiez] Hôpital Henri Mondor Centre Hospitalier Régional Universitaire de Besançon CHU Rouen Centre Esquirol [CHU Caen] Hôpital Henri Mondor Institut de recherche en santé, environnement et travail Institut de transplantation urologie-néphrologie Centre de Recherche Saint-Antoine Institut Toulousain des Maladies Infectieuses et Inflammatoires Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Microbes Evolution Phylogénie et Infections Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Vecteurs - Infections tropicales et méditerranéennes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail CHU Tenon [AP-HP] Génomique évolutive, modélisation et santé CHU Tenon [AP-HP]
• Publié dans Pathogens le 26/10/2020

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Résumé : Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. We sought to describe overall and graft survival based on whether KT patients with cryptococcosis developed CM or not. Clinical indicators of CNS involvement and brain radiological characteristics were assessed. Eighty-eight cases of cryptococcosis were diagnosed during the study period, with 61 (69.3%) cases of CM. Mortality was high (32.8%) at 12 months (M12) but not significantly different whether or not patients presented with CM. Baseline hyponatremia and at least one neurological symptom were independently associated with CM (p < 0.001). Positive serum cryptococcal antigen at diagnosis was also significantly associated with CM (p < 0.001). On magnetic resonance imaging (MRI), three patterns of brain injury were identified: parenchymal, meningeal, and vascular lesions. Although CM does not affect graft function directly, it entails a grim prognosis.

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Fichiers liés : pathogens-11-00699.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Youssef AidibiPierre BeaujeanJean QuertinmontJulien StiennonMaxime HodéePhilippe LericheJérôme BerthetStéphanie DelbaereBenoît ChampagneLionel Sanguinet
• Organismes : MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou
• Publié dans Dyes and Pigments le 01/11/2020

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Fichiers liés : S0143720822001929.pdf

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