Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 30/04/2022
• Auteurs : Maha KooliAntoine HeraudHenri-Pierre CharlesBastien GiraudRoman GauchiMona EzzadeenKevin MambuV. EgloffJean-Philippe Noël
• Organismes : Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes
• Publié dans ACM Journal on Emerging Technologies in Computing Systems le 02/11/2020

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Résumé : This article presents Computational SRAM (C-SRAM) solution combining In- and Near-Memory Computing approaches. It allows performing arithmetic, logic, and complex memory operations inside or next to the memory without transferring data over the system bus, leading to significant energy reduction. Operations are performed on large vectors of data occupying the entire physical row of C-SRAM array, leading to high performance gains. We introduce the C-SRAM solution in this article as an integrated vector processing unit to be used by a scalar processor as an energy-efficient and high performing co-processor. We detail the C-SRAM system design on different levels: (i) circuit design and silicon proof of concept, (ii) system interface and instruction set architecture, and (iii) high-level software programming and simulation. Experimental results on two complete memory-bound applications, AES and MobileNetV2, show that the C-SRAM implementation achieves up to 70× timing speedup and 37× energy reduction compared to scalar architecture, and up to 17× timing speedup and 5× energy reduction compared to SIMD architecture.

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• Type de publi. : Article dans une revue
• Date de publi. : 27/04/2022
• Auteurs : Romain DemeulemeesterNicolas SavyMichaël MouniéLaurent MolinierCyrille DelpierrePierre DellamonicaClotilde AllavenaPascal PugliesseLise CuzinPhilippe Saint-PierreNadège Costa
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Institut de Mathématiques de Toulouse UMR5219 Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Universitaire de Toulouse Equipe EQUITY (CERPOP) Equipe EQUITY (CERPOP) Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nice Equipe EQUITY (CERPOP) Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Institut de Mathématiques de Toulouse UMR5219 Institut Universitaire de Technologie - Paul Sabatier Centre Hospitalier Universitaire de Toulouse Equipe EQUITY (CERPOP)
• Publié dans BMC Health Services Research le 01/11/2020

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Résumé : Background: In a context where the economic burden of HIV is increasing as HIV patients now have a close to normal lifespan, the availability of generic antiretrovirals commonly prescribed in 2017 and the imminence of patent expiration are expected to provide substantial savings in the coming years. This article aims to assess the economic impact of these generic antiretrovirals in France and specifically over a five-year period. Methods: An agent-based model was developed to simulate patient trajectories and treatment use over a five-year period. By comparing the results of costs for trajectories simulated under different predefined scenarios, a budget impact model can be created and sensitivity analyses performed on several parameters of importance. Results: The potential economic savings from 2019 to 2023 generated by generic antiretrovirals range from €309 million when the penetration rate of generics is set at 10% to €1.5 billion at 70%. These savings range from €984 million to €993 million as the delay between patent and generic marketing authorisation varies from 10 to 15 years, and from €965 million to €993 million as the Negotiated Price per Unit (NPU) of generics at market-entry varies from 40 to 50% of the NPU for patents. Discussion: This economic savings simulation could help decision makers to anticipate resource allocations for further innovation in antiretrovirals therapies as well as prevention, especially by funding the Pre-Exposure Prophylaxis (PrEP) or HIV screening.

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Fichiers liés : s12913-022-07859-w.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/04/2022
• Auteurs : Claire DelacôteMathilde FavreMedhi El AmraniMassih NingarhariElise LemaitreLine Carolle Ntandja-WandjiPierre BauvinEmmanuel BoleslawskiGuillaume Y. MilletStéphanie TruantPhilippe MathurinAlexandre LouvetValérie CanvaGilles LebuffeFrançois René PruvotSébastien DharancyGuillaume Lassailly
• Organismes : Institute for Translational Research in Inflammation - U 1286 Université Grenoble Alpes - UFR Médecine Centre de Recherche des Cordeliers Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Institute for Translational Research in Inflammation - U 1286 Lille Inflammation Research International Center - U 995 Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 Laboratoire Interuniversitaire de Biologie de la Motricité Institut universitaire de France Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Claude Huriez [Lille] Hôpital Claude Huriez [Lille] Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 Institute for Translational Research in Inflammation - U 1286 Hôpital Claude Huriez [Lille] Institute for Translational Research in Inflammation - U 1286
• Publié dans United European Gastroenterology Journal le 29/10/2020

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Résumé : Abstract Liver transplant (LT) candidates with a body mass index (BMI) over 40 kg/m 2 have lower access to a liver graft without clear explanation. Thus, we studied the impact of obesity on the waiting list (WL) and aimed to explore graft proposals and refusal. Method Data between January 2007 and December 2017 were extracted from the French prospective national database: CRISTAL. Competing risk analyses were performed to evaluate predictors of receiving LT. Competitive events were (1) death/WL removal for disease aggravation or (2) improvement. The link between grade obesity, grafts propositions, and reason for refusal was studied. Results 15,184 patients were analysed: 10,813 transplant, 2847 death/dropout for aggravation, 748 redirected for improvement, and 776 censored. Mortality/dropout were higher in BMI over 35 (18% vs. 14% 1 year after listing) than in other candidates. In multivariate analysis, BMI>35, age, hepatic encephalopathy, and ascites were independent predictors of death/dropout. Candidates with a BMI ≥ 35 kg/m 2 had reduced access to LT, without differences in graft proposals. However, grafts refusal was more frequent especially for ‘morphological incompatibility’ (14.9% vs. 12.7% p < 0.01). Conclusion BMI over 35 kg/m 2 reduces access to LT with increased risk of dropout and mortality. Increased mortality and dropout could be due to a lower access to liver graft secondary to increased graft refusal for morphological incompatibility.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/04/2022
• Auteurs : Rémi PiotrowskiHasnaa BenchorfiJean‐paul LavalJean‐rené DuclèreCécile GenevoisPierre CarlesSébastien ChenuMaggy ColasJulie CornettePhilippe ThomasGaelle Delaizir
• Organismes : Institut de Recherche sur les CERamiques IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Institut de Recherche sur les CERamiques IRCER - Axe 3 : organisation structurale multiéchelle des matériaux IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Institut de Recherche sur les CERamiques IRCER - Axe 3 : organisation structurale multiéchelle des matériaux IRCER - Axe 3 : organisation structurale multiéchelle des matériaux
• Publié dans International Journal of Applied Glass Science le 30/10/2020

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Résumé : Abstract A crystallization study of the TeO 2 –InF 3 glass system shows that the specific glass composition 75TeO 2 –25InF 3 stabilizes a novel cubic anti‐glass phase within the glass matrix upon heat treatment. This peculiar crystalline phase also called “glass of anions” exhibits an interesting order/disorder coexistence, that is, a long‐range cation order but with a highly disordered anion sublattice. The thermal properties, structure and microstructure of the parent glass and corresponding glass‐ceramics have been studied. Finally, the luminescence of Yb 3+ ‐doped glass‐ceramics has been characterized, which confirmed the presence of the disordered anti‐glass phase.

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• Type de publi. : Article dans une revue
• Date de publi. : 22/04/2022
• Auteurs : Pierre-Louis DeclercqIsabelle FournelMatthieu DemeyereEléa KsiazekNicolas Meunier-BeillardAntoine RivièreCaroline ClarotJulien MaizelDavid SchnellGaetan PlantefeveAlexandre AmpereCédric DaubinBertrand SauneufPierre KalfonLaura FedericiÉlise RedureauMehdi BoustaLaurie LagacheThierry VanderlindenSaad NseirBéatrice La CombeGaël BourdinMehran MonchiMartine NyungaMichel RamakersWalid OulehriHugues GeorgesCharlotte Salmon GandonnièreJulio BadieAgathe DelboveXavier MonnetGaetan BeduneauÉlise Artaud-MacariPaul AbrahamNicolas DelbergheGurvan Le BouarArnaud-Felix MiailheSami HraiechVanessa BironneauNicholas SedillotMarie-Anne HoppeSaber Davide BarbarGeorge-Daniel CalcaianuJean DellamonicaNicolas TerziCyrille DelpierreStéphanie GélinotteJean-Philippe RigaudMarie LabruyèreMarjolaine GeorgesC BinquetJean-Pierre Quenot
• Organismes : Centre hospitalier de Dieppe Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques CHU Rouen Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Centre Hospitalier d'Abbeville Centre Hospitalier d'Abbeville Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Centre Hospitalier d'Angoulême Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre Hospitalier de Béthune Service de Soins Intensifs [CHU Caen] CH Centre Hospitalier Public du Cotentin Hôpital Louis Pasteur [Chartres] Hôpital Louis Mourier - AP-HP [Colombes] Equipe EQUITY (CERPOP)
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction: Prognosis of patients with COVID-19 depends on the severity of the pulmonary affection. The most severe cases may progress to acute respiratory distress syndrome (ARDS), which is associated with a risk of long-term repercussions on respiratory function and neuromuscular outcomes. The functional repercussions of severe forms of COVID-19 may have a major impact on quality of life, and impair the ability to return to work or exercise. Social inequalities in healthcare may influence prognosis, with socially vulnerable individuals more likely to develop severe forms of disease. We describe here the protocol for a prospective, multicentre study that aims to investigate the influence of social vulnerability on functional recovery in patients who were hospitalised in intensive care for ARDS caused by COVID-19. This study will also include an embedded qualitative study that aims to describe facilitators and barriers to compliance with rehabilitation, describe patients' health practices and identify social representations of health, disease and care. Methods and analysis: The "Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Economic Status" (RECOVIDS) study is a mixed-methods, observational, multicentre cohort study performed during the routine follow-up of post-intensive care unit (ICU) functional recovery after ARDS. All patients admitted to a participating ICU for PCR-proven SARS-CoV-2 infection and who underwent chest CT scan at the initial phase AND who received respiratory support (mechanical or not) or high-flow nasal oxygen, AND had ARDS diagnosed by the Berlin criteria will be eligible. The primary outcome is the presence of lung sequelae at 6 months after ICU discharge, defined either by alterations on pulmonary function tests, oxygen desaturation during a standardised 6 min walk test or fibrosis-like pulmonary findings on chest CT. Patients will be considered to be socially disadvantaged if they have an "Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examen de Santé" (EPICES) score ≥30.17 at inclusion. Ethics and dissemination: The study protocol and the informed consent form were approved by an independent ethics committee (Comité de Protection des Personnes Sud Méditerranée II) on 10 July 2020 (2020-A02014-35). All patients will provide informed consent before participation. Findings will be published in peer-reviewed journals and presented at national and international congresses. Trial registration number: NCT04556513.

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Fichiers liés : DECLERCQ_2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/04/2022
• Auteurs : Jean-Yves LefrantRomain PirracchioDan BenhamouMarc-Olivier FischerRosanna NjeimBernard AllaouchicheSophie BastideMatthieu BiaisLionel BouvetOlivier BrissaudSorin J BrullXavier CapdevilaNicola ClausenPhilippe CuvillonChristophe DadureJean-Stéphane DavidBin DuSharon EinavVictoria EleyPatrice ForgetTomoko FujiiAnne GodierDean P GopalanSophie HamadaAhmed HasaninOlivier Joannes-BoyauSébastien KereverÉric KipnisKerstin KolodzieRuth LandauArthur Le GallMorgan Le GuenMatthieu LegrandEmmanuel LorneFrédéric J MercierNicolas MongardonSheila MyatraArmelle Nicolas-RobinMark John PetersHervé QuintardJordi RelloPhilippe RichebéJason Alexander RobertsAntoine RocquillyFilippo SanfilippoAntoine SchneiderMircea T SofoneaFrancis VeyckemansPaul ZetlaouiAhed ZeidanLaurent ZieleskiewiczMarzena ZielinskaBritta von Ungern-SternbergOsama Abou-ArabAlice BletFanny BounesMatthieu BoissonAnaïs CaillardAude CarillionThomas ClavierDenis FrascaArthur JamesStéphanie SigautSacha RozencwajgPierre AlbaladejoHervé Bouaziz
• Organismes : Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Société française d’anesthésie et de réanimation = French Society of Anaesthesia and Intensive Care University of California [San Francisco] Société française d’anesthésie et de réanimation = French Society of Anaesthesia and Intensive Care Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Département d'anesthésiologie [CHU Caen] Société française d’anesthésie et de réanimation = French Society of Anaesthesia and Intensive Care Société française d’anesthésie et de réanimation = French Society of Anaesthesia and Intensive Care Hospices Civils de Lyon Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Bordeaux Hospices Civils de Lyon Centre Hospitalier Universitaire de Bordeaux Mayo Clinic [Jacksonville] Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier Odense University Hospital Unité de réanimation médicale [CHU de Carémeau, Nîmes] Hôpital Universitaire Carémeau [Nîmes] Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hospices Civils de Lyon Peking Union Medical College Hospital [Beijing] The Hebrew University of Jerusalem The University of Queensland University of Aberdeen The Jikei University School of Medicine Hôpital Européen Georges Pompidou [APHP] University of KwaZulu-Natal [Durban, Afrique du Sud] The Jikei University School of Medicine Cairo University Service de Réanimation Médicale [CHU Bordeaux] Département d’Anesthésie-Réanimation-SMUR [Hôpital Lariboisière] Marqueurs cardiovasculaires en situation de stress Centre Hospitalier Régional Universitaire [CHU Lille] University of California [San Francisco] Columbia University Medical Center Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hôpital Foch [Suresnes] University of California [San Francisco] Simplification des soins chez les patients complexes - UR UPJV 7518 Clinique du Millénaire - Oc Santé [Montpellier] AP-HP - Hôpital Antoine Béclère [Clamart] Hôpital Henri Mondor Homi Bhabha National Institute Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Great Ormond Street Hospital for Children NHS Foundation Trust [London, UK] Centre Hospitalier Universitaire de Nice Universitat Internacional de Catalunya [Barcelona] Hôpital Maisonneuve-Rosemont The University of Queensland Service des Urgences [CHU Nantes] Università degli studi di Catania = University of Catania Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Hôpital Jeanne de Flandres Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia] Service Anesthésie et Réanimation [Hôpital Nord - APHM] Wrocław Medical University The University of Western Australia CHU Amiens-Picardie Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Hôpital de la Croix-Rousse [CHU - HCL] Centre de Recherche en Cancérologie de Lyon Service SAMU-SMUR [CHU Toulouse] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Service des urgences [CHU Poitiers] = Emergency Department (ER) [Poitiers University Hospital] Hôpital de la Cavale Blanche - CHRU Brest CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Service de Réanimation Médicale [CHU Rouen] Endothélium, valvulopathies et insuffisance cardiaque Service des urgences [CHU Poitiers] = Emergency Department (ER) [Poitiers University Hospital] methodS in Patients-centered outcomes and HEalth ResEarch CHU Pitié-Salpêtrière [AP-HP] Hôpital Beaujon [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Université Grenoble Alpes - UFR Médecine Société française d’anesthésie et de réanimation = French Society of Anaesthesia and Intensive Care Service de Réanimation Médicale [CHRU Nancy] Société française d’anesthésie et de réanimation = French Society of Anaesthesia and Intensive Care
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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Résumé : War is back in Europe. With all its horrific pictures and live videos. In its report issued on the 24th of March 2022, the World Health Organization (WHO) [1] states that the Ukrainian conflict has involved 18 million persons so far, with 3.4 million refugees in bordering countries and 6.4 million persons internally displaced (Fig. 1). In this report, 1,035 deaths and 1,650 civilian injuries were reported in Ukraine without any reported data from Russia.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2022
• Auteurs : Cindy Le HelPierre AlcouffeAntoine LucasPhilippe CassagnauVéronique Bounor-Legaré
• Organismes : Ingénierie des Matériaux Polymères Ingénierie des Matériaux Polymères Hutchinson SA Ingénierie des Matériaux Polymères Ingénierie des Matériaux Polymères
• Publié dans Materials Chemistry and Physics le 28/10/2020

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Résumé : PP/EPDM Thermoplastic Vulcanizate (TPV) filled with carbon black (CB) has been prepared and the localization of the filler in the blend was depending on the crosslinking chemistry: in the rubber phase when the EPDM was crosslinked with phenolic resin (resol) and at the interface when the EPDM was crosslinked with dicumyl peroxide (DCP). It was proved, based on model reactions that mimicked what could happen during the process at high temperature, that DCP led to polymer chains grafting at the surface of the CB. This phenomenon was additional to the classical EPDM crosslinking and PP β-scission reactions. These reactions involved a modification of the interfacial tensions within this ternary blend, and explained preferentially the carbon black localization at the interface between the PP and the EPDM.

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Fichiers liés : TPV-CB2022-02-23.pdf

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• Type de publi. : Rapport
• Date de publi. : 15/04/2022
• Auteurs : Julien MichelOlivier HagolleJean-Marc DelvitMartin ThierryLebegue LaurentDavid LaubierJean Philippe MaletLegenne JéromeJoël MichaudVinasco-Salinas JuanChristelle IliopoulosSébastien Le CorrePauline DusseuxAndreas KääbHervé YesouJeremie MouginotStéphanie BattistonStephen ClandillonErwin W J BergsmaEtienne BerthierAntoine LucasJean-François DejouxGérard DedieuAnne PuissantSylvain FerrantDavid SheerenAntoine LefevreJean-Philippe CantouJean-François CrétauxRafael AlmarCamille LelongPierre MaurelJean-François FaureJean NabucetThomas CorpettiPierre-Alexis Herrault
• Organismes : Centre d'études spatiales de la biosphère Centre National d'Études Spatiales [Toulouse] Centre d'études spatiales de la biosphère Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Centre National d'Etudes Spatiales - Direction Des Lanceurs. Ecole et Observatoire des Sciences de la Terre Centre National d'Études Spatiales [Toulouse] Centre National d'Etudes Spatiales - Direction Des Lanceurs. Centre d'études spatiales de la biosphère Centre National d'Études Spatiales [Toulouse] Laboratoire Interdisciplinaire Solidarités, Sociétés, Territoires Pacte, Laboratoire de sciences sociales University of Oslo Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Institut des Géosciences de l’Environnement Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Centre National d'Etudes Spatiales - Direction Des Lanceurs. Laboratoire d'études en Géophysique et océanographie spatiales Institut de Physique du Globe de Paris Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Laboratoire Image, Ville, Environnement Centre d'études spatiales de la biosphère Dynamiques et écologie des paysages agriforestiers Kermap [Rennes] Institut National de l'Information Géographique et Forestière [IGN] Laboratoire d'études en Géophysique et océanographie spatiales Centre National d'Études Spatiales [Toulouse] Institut de Recherche pour le Développement Territoires, Environnement, Télédétection et Information Spatiale Département Environnements et Sociétés Territoires, Environnement, Télédétection et Information Spatiale UMR 228 Espace-Dev, Espace pour le développement Littoral, Environnement, Télédétection, Géomatique UMR 6554 Centre National de la Recherche Scientifique Littoral, Environnement, Télédétection, Géomatique UMR 6554 Laboratoire Image, Ville, Environnement

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Fichiers liés : sentinel-hr_phase0_report.pdf

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• Type de publi. :
• Date de publi. : 10/04/2022
• Auteurs : Léa ProchassonJean-Philippe RobinMartine PalmaDidier DécimoFabrice LejeunePierre JalinotVincent Mocquet
• Organismes : Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule

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• Type de publi. : Article dans une revue
• Date de publi. : 08/04/2022
• Auteurs : Madli BayotMorgane GerardPhilippe DerambureKathy DujardinLuc DefebvreNacim BetrouniArnaud Delval
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
• Publié dans Clinical Neurophysiology le 30/10/2020

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Résumé : Introduction: The pathophysiology of freezing of gait in people with Parkinson's disease (PD) remains unclear, despite its association with motor, cognitive, limbic and sensory-perceptual impairments. Resting-state electroencephalography (EEG) may provide functional information for a better understanding of freezing of gait by studying spectral power and connectivity between brain regions in different frequency bands.Methods: High-resolution EEG was recorded in 36 patients with PD (18 freezers, 18 non-freezers), and 18 healthy controls during a 5-min resting-state protocol with eyes open, followed by a basic spectral analysis in the sensor space and a more advanced analysis of functional connectivity at the source level.Results: Freezers showed a diffusely higher theta-band relative spectral power than controls. This increased power was correlated with a deficit in executive control. Concerning resting-state functional connectivity, connectivity strength within a left fronto-parietal network appeared to be higher in freezers than in controls in the theta band, and to be correlated with freezing severity and a history of falls.Conclusion: We have shown that spectral power and connectivity analyses of resting-state EEG provide useful and complementary information to better understand freezing of gait in PD. The higher connectivity strength seen within the left ventral attention network in freezers is in keeping with an excessive guidance of behavior by external cues, due to executive dysfunction, and spectral analysis also found changes in freezers that was closely correlated with executive control deficits. This exaggerated influence of the external environment might result in behavioral consequences that contribute to freezing of gait episodes. These findings should be further investigated with a longitudinal study.

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Fichiers liés : S0987705322000181.pdf

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