Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 08/04/2022
• Auteurs : Madli BayotMorgane GerardPhilippe DerambureKathy DujardinLuc DefebvreNacim BetrouniArnaud Delval
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
• Publié dans Clinical Neurophysiology le 30/10/2020

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Résumé : Introduction: The pathophysiology of freezing of gait in people with Parkinson's disease (PD) remains unclear, despite its association with motor, cognitive, limbic and sensory-perceptual impairments. Resting-state electroencephalography (EEG) may provide functional information for a better understanding of freezing of gait by studying spectral power and connectivity between brain regions in different frequency bands.Methods: High-resolution EEG was recorded in 36 patients with PD (18 freezers, 18 non-freezers), and 18 healthy controls during a 5-min resting-state protocol with eyes open, followed by a basic spectral analysis in the sensor space and a more advanced analysis of functional connectivity at the source level.Results: Freezers showed a diffusely higher theta-band relative spectral power than controls. This increased power was correlated with a deficit in executive control. Concerning resting-state functional connectivity, connectivity strength within a left fronto-parietal network appeared to be higher in freezers than in controls in the theta band, and to be correlated with freezing severity and a history of falls.Conclusion: We have shown that spectral power and connectivity analyses of resting-state EEG provide useful and complementary information to better understand freezing of gait in PD. The higher connectivity strength seen within the left ventral attention network in freezers is in keeping with an excessive guidance of behavior by external cues, due to executive dysfunction, and spectral analysis also found changes in freezers that was closely correlated with executive control deficits. This exaggerated influence of the external environment might result in behavioral consequences that contribute to freezing of gait episodes. These findings should be further investigated with a longitudinal study.

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Fichiers liés : S0987705322000181.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/04/2022
• Auteurs : Manon GouezOlivia PérolMaurice PérolChristophe CauxC. MenetrierMarine VillardThierry WalzerLidia DelrieuPierre SaintignyPhilippe MarijnenVincent PialouxBéatrice Fervers
• Organismes : Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon]
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction Patients with metastatic non-small cell lung cancer (mNSCLC) suffer from numerous symptoms linked to disease and treatment which may further impair the patient’s overall condition. In addition to its benefits on quality of life and fatigue, physical exercise may improve treatment response, notably due to its known effects on the immune system. The ERICA study is designed to assess the feasibility of a supervised acute physical exercise therapy realised immediately prior immune-chemotherapy infusion in patients with mNSCLC. Secondary objectives will examine the effects of acute exercise combined with an unsupervised home-walking programme on clinical, physical, psychosocial and biological parameters. Methods and analysis ERICA is a prospective, monocentric, randomised controlled, open-label feasibility study conducted at the Centre Léon Bérard Comprehensive Cancer Center (France). Thirty patients newly diagnosed with mNSCLC will be randomised (2:1 ratio) to the ‘exercise’ or the ‘control’ group. At baseline and during the last treatment cycle, participants in both groups will receive Physical Activity recommendations, and two nutritional assessments. In the exercise group, participants will receive a 3-month programme consisting of a supervised acute physical exercise session prior to immune-chemotherapy infusion, and an unsupervised home-based walking programme with an activity tracker. The acute exercise consists of 35 min interval training at submaximal intensity scheduled to terminate 15 min prior to infusion. Clinical, physical, biological and psychosocial parameters will be assessed at baseline, 3 and 6 months after inclusion. Biological measures will include immune, inflammatory, metabolic, oxidative stress biomarkers and molecular profiling. Ethics and dissemination The study protocol was approved by the French ethics committee (Comité de protection des personnes Ile de France II, N°ID-RCB 20.09.04.65226, 8 December 2020). The study is registered on ClinicalTrials.gov (NCT number: NCT04676009 ) and is at the pre-results stage. All participants will sign an informed consent form. The findings will be disseminated in peer-reviewed journals and academic conferences.

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Fichiers liés : e056819.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/04/2022
• Auteurs : Simin FlorescuDelia StanciuMihaela ZahariaAlma KosaDaniel CodreanuAneela KidwaiSobia MasoodCallum KayeAmanda CouttsLynn MackayCharlotte SummersPetra PolgarovaNeda FarahiEleonore FoxStephen McwilliamDaniel HawcuttLaura RadLaura O’malleyJennifer WhitbreadDawn JonesRachael DorePaula SaundersonOlivia KelsallNicholas CowleyLaura WildJessica ThrushHannah WoodKaren AustinJános BélteczkiIstván MagyarÁgnes FazekasSándor KovácsViktória SzőkeAdrian DonnellyMartin KellyNaoise SmythSinéad O’kaneDeclan McclintockMajella WarnockRyan CampbellEdmund MccallionAmine AzaizCyril CharronMathieu GodementGuillaume GeriAntoine Vieillard-BaronPaul JohnsonShirley MckennaJoanne HanleyAndrew CurrieBarbara AllenClare McgoldrickMoyra McmasterAshwin ManiMeghena MathewRevathi KandeepanC VigneshBharath TvN RamakrishnanAugustian JamesEvangeline ElviraDevachandran JayakumarRamachandran PratheemaSuresh BabuR EbenezerS KrishnaoorthyLakshmi RanganathanManisha GanesanMadhu ShreeEileen GuilderMagdalena ButlerKeri-Anne CowdreyMelissa RobertsonFarisha AliEllie McmahonEamon DuffyYan ChenCatherine SimmondsRachael McconnochieCaroline O’connorKhaled El-KhawasAngus RichardsonDianne HillRobert CommonsHussam AbdelkharimRajeev JhaMichael KalogirouChristine EllisVinodh KrishnamurthyAibhilin O’connorSaranya ThurairatnamDipak MukherjeeAgilan KaliappanMark VertueAnne NicholsonJoanne RichesGracie MaloneyLauren KittridgeAmanda SolesburyAngelo RamosDaniel CollinsKathy BrickellLiadain ReidMichelle SmythPatrick BreenSandra SpainGerard CurleyNatalie McevoyPierce GeogheganJennifer ClarkeJon SilversidesPeter McguiganKathryn WardAisling O’neillStephanie FinnChris WrightJackie GreenÉrin CollinsCameron KnottJulie SmithCatherine BoschertKitty SliekerEsther EwaldsArnate SandersWendy WittenbergHeidi GeurtsBrenda ReeveWilliam DechertBarbara PhillipsLaura Oritz-Ruiz de GordoaJulia AffleckYogesh ApteUmesh SubbannaRoland BartholdyThuy FrakkingJez PinnellMatt RobinsonLisa GledhillTracy WoodKaruna KeatDeepak BhonagiriRitesh SanghaviJodie NemaMegan FordHarshel ParikhBronwyn AvardMary NourseOscar HoitingMarco PetersEls RengersMirjam EversAnton PrinssenMatt MorganJade ColeHelen HillMichelle DaviesAngharad WilliamsEmma ThomasRhys DaviesMatt WisePatrick GrimmJens SoukupRichard WetzoldMadlen LöbelLisa StarkeFrancois LellouchePatricia LizottePierre DeclerqMarchalot AntoineGelinotte StephanieEraldi Jean-PierreBourgerol FrançoisBeuzelin MarionRigaud PhilippeFranck PourcineMehran MonchiDavid LuisRomain MercierAnne SagnierNathalie VerrierCécile CaplinJack RichecoeuDaniele CombauxShidasp SiamiChristelle AparicioSarah VautierAsma JeblaouiDelphine Lemaire-BrunelFrédérick CarbonneauJulie LeblondGaetan PlantefeveCécile LeparcoDamien ContouMuriel FartoukhLaura CourtinVincent LabbeGuillaume VoiriotSara SalhiMichaël ChasséFrançois CarrierDounia BoumahniFatna BenettaibAli GhamraouiArnaud SementAlexandre GachetAlexis HanischAbdelmagid HaffianeAnne-Hélène BoivinAmelie BarreauElodie GuerineauSéverine 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BrohiVijay JagannathanMichele ClarkSarah PurvisBill WetherillAna BrajkovićJakša BabelHelena SeverLidija DragijaIra KušanAhilanandan DushianthanRebecca CusackKim de Courcy-GolderKaren SalmonRachel BurnishSimon SmithSusan JacksonWinningtom RuizZoe DukeMagaret JohnsMichelle MaleKirsty GladasSatwinder VirdeeJacqueline SwabeHelen TomlinsonGernot RohdeAchim GrünewaldtJörg BojungaSirak PetrosKevin KunzBianka SchützeDirk WeismannAnna FreyMaria DrayssM.E. GoebelerThomas FlorGertrud FragnerNadine WahlJuliane TotzkeCyrus SayehliJeremy BewleyKatie SweetLisa GrimmerRebekah JohnsonRachel WyattKaren MorganSiby VargheseJoanna WillisEmma StrattonLaura KyleDaniel PutensenKay DruryAgnieszka SkorkoPamela BremmerGeraldine WardChristopher BassfordWendy SliglNadia BaigOleksa RewaSean BagshawKim BasileDara StavorDylan BurbeeAmanda McnamaraRenee WunderleyNicole BensenAaron RichardsonPeter AdamsTina VitaMegan BuhayDenise SchollMatthew GilliamJames WintersKaleigh DohertyEmily BerrymanMehrdad GhaffariOscar MarroquinKevin QuinnWilliam GarrardKyle KalchthalerGregory BeardAimee SkrtichKavitha BagavathyDebra DrapolaKayla Bryan-MorrisJohn ArnoldBob ReynoldsMahwish HussainJanice DunsavageSalim SaiyedErik HernandezJohn GoldmanCynthia BrownSusan CompJames RaczekJenny MorrisJesus Vargas Jr.Daniel WeissJoseph HensleyErik KochertChris WnukChristopher NemethBrent MoweryChristina HutchinsonLauren WintersDavid McadamsGena WalkerTami MinnierMary WisniewskiKatelyn MayakErin MccrearyElise MartinRyan BariolaAlex ViehmanJessica DaleyAlyssa LopusMark SchmidhoferRichard AmbrosinoSherbrina KeenSue ToffaloMartha StambaughKen TrimmerReno PerriSherry CasaliRebecca MedvaBrent MassarAshley BeyerlJason BurkeySheryl KeelerMaryalyce LoweryLynne OnceaJason DaughertyChanthou SevillaAmy WoelkeJulie DiceLisa WeberJason RothCindy FerringerDeborah BeerJessica FeszLillian CarpioGwenhael ColinVanessa ZinzoniNatacha MaquigneauMatthieu Henri-LagarrigueCaroline PoupletLorenz ReillMichael DistlerAstrid MaselliRobert MartynogaKara TraskAmelia ButlerBen AttwoodPenny ParsonsBridget CampbellAlex SmithValerie PageXiao ZhaoDeepali OzaGail AbrahamsonBen SheathChiara EllisPaul YoungChelsea YoungEden LesonaLeanlove NavarraRaulle CruzKirsha DelaneyRhoze CruzApril Aguilar-DanoJonathan RhodesThomas AndersonSheila MorrisRalph FuchsBridget LambertCharlotte TaiAmy ThomasAlexandra KeenCarey TierneyNimca OmerGina BaconAscanio TridenteKaren ShukerJeanette AndersSandra GreerPaula ScottAmy MillingtonPhilip BuchananJodie KirkAlexandra BinnieElizabeth PowellAlexandra McmillanTracy LukNoah ArefCraig DenmadeGirendra SaderaReni JacobCathy JonesDebbie HughesMartin SterbaWenli GengStephen DigbyDavid SouthernHarsha ReddySarah HulseAndrew CampbellMark GartonClaire WatkinsSara SmutsAlison QuinnBenjamin SimpsonCatherine McmillanCheryl FinchClaire HillJosh CooperJoanna BuddCharlotte SmallRyan O’learyJanine BirchEmma CollinsAndrew HollandPeter AlexanderTim FeltonSusan FergusonKatharine SellersLuke WardDavid YatesIsobel BirkinshawKay KellZoe ScottHarriet PearsonMadiha HashmiMaryam AliNoor HassanAshok PanjwaniZulfiqar UmraniMohiuddin ShaikhAyesha SiddiquiQuratul AinDarakhshan KanwalSjoerd van BreeMarianne Bouw-RuiterMargreet OsingaArthur van ZantenClaire ZammitSumayyah RashanNora AzerguiSara BariMercedes BeltranCurt BrugmanErika GroeneveldMina JafarzadehNicole Keijzer-TimmersEsmee KesterMaaike KoelinkMarion Kwakkenbos-CraanenClementina OkundayeLorraine ParkerSvenja PetersSophie PostIlse RietveldIrma Scheepstra-BeukersGerwin SchreuderAlbertine SmitNicole BrillingerRené MarkgrafFred EichingerPeter DoranAisha AnjumJanis Best-LaneElizabeth FagbodunFrances BartonWalton CharlesLorna MillerKaren Parry-BillingsSam PetersAlvin Richards-BelleMichelle SaullStefan SprinckmollerDaisy WileyRobert DarnellCarly AuLucy StronachAidan BurrellAndrew ForbesStephane HeritierManoj SaxenaTony TrapaniBrian CuthbertsonVenika ManoharanArjen DondropDeva JayakumarStephan EhrmannSebastiaan HullegiePedro PovoaRichard BeasleyNick DanemanRobert FowlerSteve McgloughlinDavid PatersonBala VenkateshMenno de JongTim UyekiKenneth BaillieMadhia HashmiMihai NeteaKatrina OrrAsad PatanwalaSteve TongNichola CooperJames GaleaKayode OgungbenroAsad PatawalaEmma RademakerSteven TongTaryn YoungsteinDean FergussonAnand KumarMike LaffanSylvain LotherAngelique de ManMarie-Helene MasseJacinta AbrahamDonald ArnoldPhillipe BeginRichard CharlewoodMichael ChasseJamie CooperMark CoyneJames DalyIain GosbellHeli Harvala-SimmondsSheila MaclennanJohn McdyerDavid MenonNicole PrideeDavid RobertsHelen ThomasAlan TinmouthDarrell TriulziTim WalshErica WoodCarolyn CalfeeCecilia O’kaneMurali ShyamsundarPratik SinhaTaylor ThompsonIan YoungNiall FergusonCarol HodgsonNeil OrfordJason PhuaRebecca BaronSlava EpelmanClaudia FrankfurterFrank GommansEdy KimDavid LeafMuthiah VaduganathanRoland van KimmenadeAshish SanilMarloes van BeurdenEvelien EffelaarJoost SchotsmanCraig BoydCain HarlandAudrey ShearerJess WrenGiles ClermontDaniel RickettsUdara AttanayakaSri DarshanaPramodya IshaniIshara UdayangaCharlotte BradburyPatrick LawlerSimon StanworthBryan McverryZoe McquiltenAlisa HigginsPaul MounceyFarah Al-BeidhKathryn RowanLindsay BerryElizabeth LorenziRyan ZarychanskiYaseen ArabiDjillali AnnaneAbi BeaneWilma van Bentum-PuijkZahra BhimaniShailesh BihariMarc BontenFrank BrunkhorstAdrian BuzgauMeredith BuxtonMarc CarrierAllen ChengMatthew CoveMichelle DetryLise EstcourtMark FitzgeraldTimothy GirardEwan GoligherHerman GoossensRashan HaniffaThomas HillsDavid HuangChristopher HorvatBeverley HuntNao IchiharaFrancois LamontagneHelen LeavisKelsey LinstrumEdward LittonJohn MarshallDaniel McauleyAnna McglothlinShay McguinnessSaskia MiddeldorpStephanie MontgomerySusan MorpethSrinivas MurthyMatthew NealAlistair NicholRachael ParkeJane ParkerLuis ReyesHiroki SaitoMarlene SantosChristina SaundersAry Serpa-NetoChristopher SeymourManu Shankar-HariVanessa SinghTimo TolppaAlexis TurgeonAnne TurnerFrank van de VeerdonkCameron GreenRoger LewisDerek AngusColin McarthurScott BerryLennie DerdeSteve WebbAnthony Gordon
• Organismes : Clinical Pharmacology University of Cambridge [Cambridge, UK] Université de Strasbourg Université de Strasbourg Université de Strasbourg Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans JAMA Cardiology le 25/10/2020

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Résumé : Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. Objective To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. Design, Setting, and Participants In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions within multiple therapeutic domains, 1557 critically ill adult patients with COVID-19 were enrolled between October 30, 2020, and June 23, 2021, from 105 sites in 8 countries and followed up for 90 days (final follow-up date: July 26, 2021). Interventions Patients were randomized to receive either open-label aspirin (n = 565), a P2Y12 inhibitor (n = 455), or no antiplatelet therapy (control; n = 529). Interventions were continued in the hospital for a maximum of 14 days and were in addition to anticoagulation thromboprophylaxis. Main Outcomes and Measures The primary end point was organ support–free days (days alive and free of intensive care unit–based respiratory or cardiovascular organ support) within 21 days, ranging from −1 for any death in hospital (censored at 90 days) to 22 for survivors with no organ support. There were 13 secondary outcomes, including survival to discharge and major bleeding to 14 days. The primary analysis was a bayesian cumulative logistic model. An odds ratio (OR) greater than 1 represented improved survival, more organ support–free days, or both. Efficacy was defined as greater than 99% posterior probability of an OR greater than 1. Futility was defined as greater than 95% posterior probability of an OR less than 1.2 vs control. Intervention equivalence was defined as greater than 90% probability that the OR (compared with each other) was between 1/1.2 and 1.2 for 2 noncontrol interventions. Results The aspirin and P2Y12 inhibitor groups met the predefined criteria for equivalence at an adaptive analysis and were statistically pooled for further analysis. Enrollment was discontinued after the prespecified criterion for futility was met for the pooled antiplatelet group compared with control. Among the 1557 critically ill patients randomized, 8 patients withdrew consent and 1549 completed the trial (median age, 57 years; 521 [33.6%] female). The median for organ support–free days was 7 (IQR, −1 to 16) in both the antiplatelet and control groups (median-adjusted OR, 1.02 [95% credible interval {CrI}, 0.86-1.23]; 95.7% posterior probability of futility). The proportions of patients surviving to hospital discharge were 71.5% (723/1011) and 67.9% (354/521) in the antiplatelet and control groups, respectively (median-adjusted OR, 1.27 [95% CrI, 0.99-1.62]; adjusted absolute difference, 5% [95% CrI, −0.2% to 9.5%]; 97% posterior probability of efficacy). Among survivors, the median for organ support–free days was 14 in both groups. Major bleeding occurred in 2.1% and 0.4% of patients in the antiplatelet and control groups (adjusted OR, 2.97 [95% CrI, 1.23-8.28]; adjusted absolute risk increase, 0.8% [95% CrI, 0.1%-2.7%]; 99.4% probability of harm). Conclusions and Relevance Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. Trial Registration ClinicalTrials.gov Identifier: NCT02735707

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 05/04/2022
• Auteurs : Géraldine GuérillotJean-Luc MoriceauPierre-Antoine ChardelPhilippe Castelnau
• Organismes : Umalis lab (ESCP Europe & Institut Mines-Télécom-Télécom Ecole de Management) Département Droit, Économie et Finances Laboratoire en Innovation, Technologies, Economie et Management (EA 7363) Département Droit, Économie et Finances Institut interdisciplinaire d'anthropologie du contemporain Laboratoire Sens et Compréhension du Monde Contemporain Département Droit, Économie et Finances Laboratoire en Innovation, Technologies, Economie et Management (EA 7363)

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Fichiers liés : RSENumériqueChapitre_9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/04/2022
• Auteurs : Céline BellenguezFahri KucukaliIris E. JansenLuca KleineidamSonia Moreno-GrauNajaf AminAdam C. NajRafael Campos-MartinBenjamin Grenier-BoleyVictor AndradePeter A. HolmansAnne BolandVincent DamotteSven J. van Der LeeMarcos R. CostaTeemu KuulasmaaQiong YangItziar de RojasJoshua C. BisAmber YaqubIvana ProkicJulien ChapuisShahzad AhmadVilmantas GiedraitisDag AarslandPablo Garcia-GonzalezCarla AbdelnourEmilio Alarcon-MartinDaniel AlcoleaMontserrat AlegretIgnacio AlvarezVictoria AlvarezNicola J. ArmstrongAnthoula TsolakiCarmen AntunezIldebrando AppollonioMarina ArcaroSilvana ArchettiAlfonso Arias PastorBeatrice ArosioLavinia AthanasiuHenri BaillyNerisa BanajMiquel BaqueroSandra BarralAlexa BeiserAna Belen PastorJennifer E. BelowPenelope BenchekLuisa BenussiClaudine BerrCéline BesseValentina BessiGiuliano BinettiAlessandra BizarroRafael BlesaMerce BoadaEric BoerwinkleBarbara BorroniSilvia BoschiPaola BossuGeir BrathenJan BresslerCatherine BresnerHenry BrodatyKeeley J. BrookesLuis Ignacio BruscoDolores Buiza-RuedaKatharina BurgerVanessa BurholtWilliam S. BushMiguel CaleroLaura B. CantwellGenevieve CheneJaeyoon ChungMichael L. CuccaroAngel CarracedoRoberta CecchettiLaura Cervera-CarlesCamille CharbonnierHung-Hsin ChenCaterina ChillottiSimona CicconeJurgen A. H. R. ClaassenChristopher ClarkElisa ContiAnais Corma-GomezEmanuele CostantiniCarlo CustoderoDelphine DaianMaria Carolina DalmassoAntonio DanieleEfthimios DardiotisJean-Francois DartiguesPeter Paul de DeynKatia de Paiva LopesLot D. de WitteStéphanie DebetteJurgen DeckertTeodoro del SerNicola DenningAnita DestefanoMartin DichgansJanine Diehl-SchmidMonica Diez-FairenPaolo Dionigi RossiSrdjan DjurovicEmmanuelle DuronEmrah DuzelCarole DufouilGudny EiriksdottirSebastiaan EngelborghsValentina Escott-PriceAna EspinosaMichael EwersKelley M. FaberTagliavini FabrizioSune Fallgaard NielsenDavid W. FardoLucia FarottiChiara FenoglioMarta Fernandez-FuertesRaffaele FerrariCatarina B. FerreiraEvelyn FerriBertrand FinPeter FischerTormod FladbyKlaus FliessbachBernard FongangMyriam FornageJuan ForteaTatiana M. ForoudSilvia FostinelliNick C. FoxEmlio Franco-MaciasMaria J. BullidoAna Frank-GarciaLutz FroelichBrian Fulton-HowardDaniela GalimbertiJose Maria Garcia-AlbercaSebastian Garcia-MadronaGuillermo Garcia-RibasRoberta GhidoniIna GieglingGiaccone GiorgioAlison M. GoateOliver GoldhardtDuber Gomez-FonsecaAntonio Gonzalez-PerezCaroline GraffGiulia GrandeEmma GreenTimo GrimmerEdna GrunblattMichelle GruninVilmundur GudnasonTamar Guetta-BaranesAnnakaisa HaapasaloGeorgios HadjigeorgiouJonathan L. HainesKara L. Hamilton-NelsonHarald HampelOlivier HanonJohn HardyAnnette M. HartmannLucrezia HausnerJanet HarwoodStefanie Heilmann-HeimbachSeppo HelisalmiMichael T. HenekaIsabel HernandezMartin J. HerrmannPer HoffmannClive HolmesHenne HolstegeRaquel Huerto VilasMarc HulsmanJack HumphreyGeert Jan BiesselsXueqiu JianCharlotte JohanssonGyungah R. JunYuriko KastumataJohn KauwePatrick G. KehoeLena KilanderAnne Kinhult StahlbomMiia KivipeltoAnne KoivistoJohannes KornhuberMary H. KosmidisWalter A. KukullPavel P. KuksaBrian W. KunkleAmanda B. KuzmaCarmen LageErika J. LaukkaLenore LaunerAlessandra LauriaChien-Yueh LeeJenni LehtisaloOndrej LerchAlberto LleoWilliam Jr LongstrethOscar LopezAdolfo Lopez de MunainSeth LoveMalin LowemarkLauren LuckcuckKathryn L. LunettaYiyi MaJuan MaciasCatherine A. MacleodWolfgang MaierFrancesca MangialascheMarco SpallazziMarta MarquieRachel MarshallEden R. MartinAngel Martin MontesCarmen Martinez RodriguezCarlo MasulloRichard MayeuxSimon MeadPatrizia MecocciMiguel MedinaAlun MeggyShima MehrabianSilvia MendozaManuel Menendez-GonzalezPablo MirSusanne MoebusMerel MolLaura Molina-PorcelLaura MontrrealLaura MorelliFermin MorenoKevin MorganThomas MosleyMarkus M. NothenCarolina MuchnikShubhabrata MukherjeeBenedetta NacmiasTiia NganduGael NicolasBorge G. NordestgaardRobert OlasoAdelina OrellanaMichela OrsiniGemma OrtegaAlessandro PadovaniCaffarra PaoloGoran PapenbergLucilla ParnettiFlorence PasquierPau PastorGina PelosoAlba Perez-CordonJordi Perez-TurPierre PericardOliver PetersYolande A. L. PijnenburgJuan A. PinedaGerard Pinol-RipollClaudia PisanuThomas PolakJulius PoppDanielle PosthumaJosef PrillerRaquel PuertaOlivier QuenezInes QuintelaJesper Qvist ThomassenAlberto RabanoInnocenzo RaineroFarid RajabliInez RamakersLuis M. RealMarcel J. T. ReindersChristiane ReitzDolly Reyes-DumeyerPerry RidgeSteffi Riedel-HellerPeter RiedererNatalia RobertoEloy Rodriguez-RodriguezArvid RongveIrene Rosas AllendeMaitee Rosende-RocaJose Luis RoyoElisa RubinoDan RujescuMaria Eugenia SaezParaskevi SakkaIngvild SaltvedtAngela SanabriaMaria Bernal Sanchez-ArjonaFlorentino Sanchez-GarciaPascual Sanchez JuanRaquel Sanchez-ValleSigrid B. SandoChloe SarnowskiClaudia L. SatizabalMichela ScamosciNikolaos ScarmeasElio ScarpiniPhilip ScheltensNorbert ScherbaumMartin SchererMatthias SchmidAnja SchneiderJonathan M. SchottGeir SelbaekDavide SeripaManuel SerranoJin ShaAlexey A. ShadrinOlivia SkrobotSusan SliferGijsje J. L. SnijdersHilkka SoininenVincenzo SolfrizziAlina SolomonYeunjoo SongSandro SorbiOscar Sotolongo-GrauGianfranco SpallettaAnnika SpottkeAlessio SquassinaEystein StordalJuan Pablo TartanLluis TarragaNiccolo TesiAnbupalam ThalamuthuTegos ThomasGiuseppe TostoLatchezar TraykovLucio TremolizzoAnne Tybjaerg-HansenAndre UitterlindenAbbe UllgrenIngun UlsteinSergi ValeroOtto ValladaresChristine Van BroeckhovenJeffery VanceBadri N. VardarajanAad van Der LugtJasper Van DongenJeroen van RooijJohn van SwietenRik VandenbergheFrans VerheyJean-Sebastien VidalJonathan VogelgsangMartin VyhnalekMichael WagnerDavid WallonLi-San WangRuiqi WangLeonie WeinholdJens WiltfangGill WindleBob WoodsMary YannakouliaHabil ZareYi ZhaoXiaoling ZhangCongcong ZhuMiren ZulaicaLindsay A. FarrerBruce M. PsatyMohsen GhanbariTowfique RajPerminder SachdevKaren MatherFrank JessenM. Arfan IkramAlexandre de MendoncaJakub HortMagda TsolakiMargaret A. Pericak-VancePhillippe AmouyelJulie WilliamsRuth Frikke-SchmidtJordi ClarimonJean-Francois DeleuzeGiacomina RossiSudha SeshadriOle A. AndreassenMartin IngelssonMikko HiltunenKristel SleegersGerard D. SchellenbergCornelia M. van DuijnRebecca SimsWiesje M. van Der FlierAgustin RuizAlfredo RamirezJean-Charles Lambert
• Organismes : Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre National de Recherche en Génomique Humaine Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies Centre National de Recherche en Génomique Humaine Bordeaux population health Centre National de Recherche en Génomique Humaine Bordeaux population health Bordeaux population health Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies Bordeaux population health Centre National de Recherche en Génomique Humaine Groupe de recherche clinique Alzheimer Precision Medicine Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies Centre National de Recherche en Génomique Humaine Lille Neurosciences & Cognition - U 1172 Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies Bordeaux population health Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
• Publié dans Nature Genetics le 29/10/2020

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Résumé : Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.

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Fichiers liés : BPH_NG_2022_Bellenguez.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/04/2022
• Auteurs : Jean FurstossPierre HirelPhilippe CarrezPatrick Cordier
• Organismes : Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/04/2022
• Auteurs : Guillaume CourtierRonan AdamPierre-Jean LaprayEmmanuel PecheurSébastien ChangeyJean-Philippe Lauffenburger
• Organismes : Institut franco-allemand de recherches de Saint-Louis = French-German Research Institute of Saint-Louis = Deutsch-Französisches Forschungsinstitut Saint-Louis Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 Institut franco-allemand de recherches de Saint-Louis = French-German Research Institute of Saint-Louis = Deutsch-Französisches Forschungsinstitut Saint-Louis Institut de Recherche en Informatique Mathématiques Automatique Signal

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2022
• Auteurs : Jean-Eudes FahrnerImran LahmarAnne-Gaëlle GoubetYacine HaddadAgathe CarrierMarine MazzengaDamien DrubayCarolina Alves Costa SilvaEric de SousaCassandra ThelemaqueCléa MelenotteAgathe DubuissonArthur GeraudGladys FerrereRoxanne BirebentCamille BigenwaldMarion PicardLuigi CerboneJoana LériasAriane LaparraAlice Bernard-TessierBenoît KloecknerMarianne GazzanoFrançois-Xavier DanlosSafae TerrisseEugenie PizzatoCaroline FlamentPierre LyEric TartourNadine BenhamoudaLydia MezianiAbdelhakim Ahmed-BelkacemMakoto MiyaraGuy GorochovFabrice BarlésiAlexandre TrubertBenjamin UngarYeriel EstradaCaroline PradonEmmanuelle GalloisFanny PommeretEmeline ColombaPernelle LavaudMarc DelogerNathalie M DroinEric W. DeutschBertrand GachotJean-Philippe SpanoMansouria MeradFlorian ScottéAurélien MarabelleFrank GriscelliJean-Yves BlayJean-Charles SoriaMiriam MeradFabrice AndréJuliette VillemonteixMathieu ChevalierSophie Caillat-ZucmanFlorence FenollarEmma Guttman-YasskyOdile LaunayGuido KroemerBernard La ScolaMarkus MaeurerLisa DerosaLaurence Zitvogel
• Organismes : Université Paris-Saclay Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Oncostat Oncostat Institut Gustave Roussy Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy] Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Département de médecine oncologique [Gustave Roussy] Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy] Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy] Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Immunologie anti-tumorale et immunothérapie des cancers Centre d'Investigation Clinique en Biotherapie des cancers Radiothérapie Moléculaire et Innovation Thérapeutique Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse Radiothérapie Moléculaire et Innovation Thérapeutique Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse Modèles de Cellules Souches Malignes et Thérapeutiques Prédicteurs moléculaires et nouvelles cibles en oncologie Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Centre de Recherche des Cordeliers Plateforme de métabolomique Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection AP-HP. Université Paris Saclay Prédicteurs moléculaires et nouvelles cibles en oncologie
• Publié dans Cancer Discovery le 03/10/2017

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Résumé : Abstract Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized the polarity and specificity of memory T cells directed against SARS-CoV-2 viral lysates and peptides to determine correlates with spontaneous, virus-elicited, or vaccine-induced protection against COVID-19 in disease-free and cancer-bearing individuals. A disbalance between type 1 and 2 cytokine release was associated with high susceptibility to COVID-19. Individuals susceptible to infection exhibited a specific deficit in the T helper 1/T cytotoxic 1 (Th1/Tc1) peptide repertoire affecting the receptor binding domain of the spike protein (S1-RBD), a hotspot of viral mutations. Current vaccines triggered Th1/Tc1 responses in only a fraction of all subject categories, more effectively against the original sequence of S1-RBD than that from viral variants. We speculate that the next generation of vaccines should elicit Th1/Tc1 T-cell responses against the S1-RBD domain of emerging viral variants. Significance: This study prospectively analyzed virus-specific T-cell correlates of protection against COVID-19 in healthy and cancer-bearing individuals. A disbalance between Th1/Th2 recall responses conferred susceptibility to COVID-19 in both populations, coinciding with selective defects in Th1 recognition of the receptor binding domain of spike. See related commentary by McGary and Vardhana, p. 892. This article is highlighted in the In This Issue feature, p. 873

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• Type de publi. : Rapport
• Date de publi. : 01/04/2022
• Auteurs : Muriel GandelinMaryse AlvitreEmilie BlaiseAurélien BoloJean-Pierre BraccoJean-Yves BreuilFrédéric ChandevauGilles EscallonIsabel FigueiralCyril GaillardGuillaume HulinChristophe JordaCécile JungCaroline HamonRomain MarsacSophie MartinPhilippe PonelPierre RascalouStéphanie RauxMaxime RemicourtYoann ThouvenotHélène VergélyFrédéric VinolasJulia WattezPaul ZollerRebecca Fritz
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Institut méditerranéen de biodiversité et d'écologie marine et continentale Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Laboratoire méditerranéen de préhistoire Europe-Afrique Aix Marseille Université Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols Institut national de recherches archéologiques préventives Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Archéologie des Sociétés Méditerranéennes Trajectoires - UMR 8215 Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Archéologie des Sociétés Méditerranéennes Institut méditerranéen de biodiversité et d'écologie marine et continentale Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives - Centre de recherches archéologiques de Nîmes Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives - Centre de recherches archéologiques de Nîmes Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives

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Résumé : ’opération archéologique de Pascale et Bérange, située à cheval sur les communes de Saint‑Brès et de Mudaison (Hérault), a révélé une vaste occupation du Néolithique final (2600‑2200 av. n. è.) et des témoins de fréquentation paléolithiques, néolithiques et protohistoriques. Sur la première zone de fouille, située à Mudaison, les niveaux de sols ne sont pas conservés et l’essentiel des découvertes consiste en plusieurs fosses, fossés et calages de palissades se rapportant à la fin du Néolithique. L’opération a permis d’appréhender entre la moitié et les deux tiers du réseau principal de creusement curvilinéaires et le plan a pu être complété, dans sa partie orientale, par une prospection électrique. Les vestiges mis au jour correspondent au palimpseste d’enceintes fontbouïsses successives qui cernent une surface estimée entre 2000 et 4000 m². La variété et la nature des mobiliers découverts sur l’ensemble du site évoquent les vestiges habituellement présents en contexte d’habitat chalcolithique, ce qui permet de penser que ces différentes occupations correspondent à autant d’installations villageoises successives. Cette aussi dans cette zone que des épandages d’industrie lithique se rapportant à la fin du Paléolithique ont été découverts. Ils témoignent de la fréquentation récurrente de ce secteur par plusieurs groupes de chasseurs‑ cueilleurs. À Saint‑Brès, sur la deuxième zone de fouille, plusieurs sols anciens s’étagent du Néolithique à l’âge du fer. Il ne s’agit pas de sols d’habitats mais plutôt de niveaux situés en périphérie des occupations. L’hypothèse qu’il s’agisse de champs anciens installés dans ce secteur particulièrement propice à l’agriculture est privilégiée. Un sondage profond a également permis de dater du début du Néolithique ancien un paléochenal du Bérange qui avait conservé, dans ses parties les plus profondes, les espèces végétales et animales qui peuplaient ce cours d’eau au début de l’Holocène.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2022
• Auteurs : Alexandre RouenEli RogersVeronique KerlanBrigitte DelemerSophie Catteau-JonardYves ReznikAnne GompelIsabelle CedrinAnne-Marie GuedjVirginie GrouthierThierry BrueCatherine PienkowskiAnne BachelotSandra Chantot-BastaraudAlexandra RousseauTabassome SimonEsther KottJean-Pierre SiffroiPhilippe TouraineSophie Christin-Maitre
• Organismes : Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] CHU Trousseau [APHP] Hôpital universitaire Robert Debré [Reims] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hopital port Royal Hôpital Jean Verdier [AP-HP] Hôpital Universitaire Carémeau [Nîmes] Marseille medical genetics - Centre de génétique médicale de Marseille Institut Marseille Maladies Rares Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Saint-Antoine [AP-HP]
• Publié dans Fertility and Sterility le 24/10/2020

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Résumé : Objective: To study the diagnostic yield, including variants in genes yet to be incriminated, of whole exome sequencing (WES) in familial cases of premature ovarian insufficiency (POI). Design: Cross-sectional study. Setting: Endocrinology and reproductive medicine teaching hospital departments. Patients: Familial POI cases were recruited as part of a nationwide multicentric cohort. A total of 36 index cases in 36 different families were studied. Fifty-two relatives were available, including 25 with POI and 27 affected who were nonaffected. Karyotype analysis, FMR1 screening, single nucleotide polymorphism array analysis, and WES were performed in all subjects. Interventions: None. Main Outcome Measures: The primary outcome was a molecular etiology, as diagnosed by karyotype, FMR1 screening, single nucleotide polymorphism array, and WES. Results: A likely molecular etiology (pathogenic or likely pathogenic variant) was identified in 18 of 36 index cases (50% diagnostic yield). In 12 families, we found a pathogenic or likely pathogenic variant in a gene previously incriminated in POI, and in 6 families, we found a pathogenic or likely pathogenic variant in new candidate genes. Most of the variants identified were located in genes involved in cell division and meiosis (n = 11) or DNA repair (n = 4). Conclusions: The genetic etiologic diagnosis in POI allows for genetic familial counseling, anticipated pregnancy planning, and ovarian tissue preservation or oocyte preservation. Identifying new genes may lead to future development of therapeutics in reproduction based on disrupted molecular pathways. Clinical Trial Registration Number: NCT 01177891. ((C) 2021 by American Society for Reproductive Medicine.) El resumen esta disponible en Espanol al final del articulo.

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Fichiers liés : Rouen 2022 .pdf

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