Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 23/05/2022
• Auteurs : Edwin ClatworthyArnold A. PaecklarEddy DibMaxime DebostNicolas BarrierPhilippe BoullayJean-Pierre GilsonNikolai NesterenkoSvetlana Mintova
• Organismes : Laboratoire catalyse et spectrochimie Laboratoire de cristallographie et sciences des matériaux Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Laboratoire catalyse et spectrochimie Laboratoire de cristallographie et sciences des matériaux Laboratoire de cristallographie et sciences des matériaux Laboratoire de cristallographie et sciences des matériaux Laboratoire catalyse et spectrochimie Laboratoire catalyse et spectrochimie Laboratoire catalyse et spectrochimie
• Publié dans ACS Applied Energy Materials le 28/10/2020

---

Résumé : The engineering of RHO nanozeolite is demonstrated by synthesis from a colloidal precursor suspension using only inorganic structure-directing agents (Na$^+$, Cs$^+$), whereby the particle morphology, Si/Al ratio, cation content, stability, and flexibility are tailored. RHO nanozeolite with a higher Si/Al ratio (2.0) and superior thermal stability (up to 700 °C) compared to previous reports is synthesized. Optimization of the synthesis procedure by introducing additional Si precursors facilitated the targeted improvement in the Si/Al ratio while maintaining the nanosized dimensions of the discrete zeolite crystals with well-defined rhombic dodecahedral morphology. The structural properties of the RHO nanozeolites are characterized by in situ variable-temperature X-ray powder diffraction (XRPD) experiments showing that the nanozeolites possess a single structural phase up to 740 °C; further heating to 760 °C induces a symmetry change from noncentrosymmetric to centrosymmetric associated with a large increase in the anisotropic displacement parameter of the Cs$^+$ extra-framework cations. The structural behavior is unique compared to more siliceous Na$^+$ and Cs$^+$-containing RHO zeolites (Si/Al ≥ 3), which possess a centrosymmetric structure when hydrated. These experiments reveal a delineation, based on the Si/Al ratio and content of the extra-framework cations between the as-synthesized Na$^+$ and Cs$^+$-containing RHO zeolites that possess centrosymmetric or noncentrosymmetric symmetry when hydrated, as well as single or coexisting structural phases, expanding the scope of intelligently designed nanozeolites with tailored properties for precise applications.

---

Fichiers liés : 313-Engineering RHO nanozeolite controlling the particle morphology, Al and cation content, stability and flexibility.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 23/05/2022
• Auteurs : Leticia PalazónSantiago BegueríaIñaki AntiguedadAnaïs Barella-OrtizYvan CaballeroRoxelane CakirIngrid ForeyYouen GrussonVivien HakounGuillaume HévinJorge JódarMathilde JungLuis Javier LambánSandra LaniniPhilippe Le CoentPierre Le CointeMaría del Carmen LlasatMontserrat LlasatErika PardoPere Quintana SeguíJ.M. Sánchez-PérezEric SauquetSabine SauvageOriol Travesset-BaroJean-Philippe VidalAne Zabaleta
• Organismes : Bureau de Recherches Géologiques et Minières Gestion de l'Eau, Acteurs, Usages Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Gestion de l'Eau, Acteurs, Usages Bureau de Recherches Géologiques et Minières Gestion de l'Eau, Acteurs, Usages Bureau de Recherches Géologiques et Minières RiverLy - Fonctionnement des hydrosystèmes

---

Résumé : The Pyrenees range is a transboundary mountain region shared by Spain, France and Andorra. As many other mountain regions, the Pyrenees host the upper catchments and recharge zones of the region's main river basins and aquifers. Therefore, it is the main source of water resources that are used in a much larger area that includes important urban concentrations and highly productive rural areas. This territory and its water resources are particularly vulnerable to the consequences of climate change. The PIRAGUA project (2018-2021, https://www.opcc-ctp.org/piragua), funded by FEDER through the POCTEFA Program of the EU, addressed the characterization of the hydrological cycle of the Pyrenees in a climate change context, in order to improve the territories’ adaptation capacity. The goals of the project were to unify and homogenize the existing information, prospect future scenarios, develop indicators of change, and propose adaptation strategies with impact on the territory. The project results were compiled in a series of regional datasets, and are available through the geo-portal of the Pyrenees Climate Change Observatory (https://opcc-ctp.org/geoportal). These include the following resources: PIRAGUA_resources stores information related to water resources use, exploitation and management; PIRAGUA_indicators contains daily streamflow and aquifer level indicators from observed series during the historical period (1950-2019); PIRAGUA_flood includes the number and classification of flood events, at the municipal level; PIRAGUA_atmos_analysis contains observation-based meteorological data suited for hydrological simulation, for the historical period (1981-2010); PIRAGUA_atmos_climate is a statistical downscaling of six global climatic models, for the historical and future periods (1981-2100); finally, two datasets include the hydrological water cycle components derived from simulations with different hydrological models (SWAT, SASER, GIS-BALAN and RECHARGE) and climate forcings: PIRAGUA_hydro_analysis (1981-2010) and PIRAGUA_hydro_climate (1981-2100). This contribution is devoted to describing these datasets and the tools to explore them and acquire the data, and to provide examples of the main results regarding the climate change effects on the Pyrenees’ water resources.

---

Source

---

• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 23/05/2022
• Auteurs : Philippe DeshayesGérard EngrandAugustin MouzeJean-Pierre Richard
• Organismes : Centrale Lille Laboratoire Paul Painlevé - UMR 8524 Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 Centrale Lille

---

Résumé : L'exercice du métier de chercheur se rapproche aujourd'hui de celui de l'ingénieur : exigence de résultats, concurrence, temporalités contraintes, montages financiers et organisationnels... Ces ingrédients s'ajoutent au questionnement scientifique. Or cette image du métier conduit souvent à passer sous silence la dimension intellectuelle et cognitive du travail de recherche, dimension dont il est difficile de rendre compte. Dans ce contexte, comment des étudiants en fin d'études supérieures – et tout particulièrement des élèves ingénieurs – se représentent-ils l'activité de recherche ? À l'heure de la professionnalisation de l'enseignement supérieur, comment leur faire appréhender cette part intellectuelle et cognitive propre à toute posture de chercheur ? Cet ouvrage est une invitation à réfléchir sur les modalités d'ouverture et de préparation à cette « recherche intérieure », essentielle à l'activité scientifique, et sur les pratiques et la posture du chercheur.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 22/05/2022
• Auteurs : Philippe LaurentJean-Pierre BaronickÉric BréelleIon CojocariStéphane ColongesMiles Lindsey-ClarkDamien PailotYuuki Wada
• Organismes : Astrophysique Interprétation Modélisation AstroParticule et Cosmologie AstroParticule et Cosmologie AstroParticule et Cosmologie Astrophysique Interprétation Modélisation AstroParticule et Cosmologie AstroParticule et Cosmologie AstroParticule et Cosmologie

---

Résumé : XGRE (X-ray, Gamma-ray and Relativistic Electrons detector) was one of the main instruments onboard the TARANIS satellite. It is an ultra-fast gamma-ray and electron detector, with a 350 ns dead time, built for measuring Terrestrial Gamma-ray Flashes (TGF). In this paper, we will shortly present the TARANIS mission, the design of the XGRE instrument and the measured performances during the instrument calibration at APC, LESIA and payload calibrations done onboard the satellite at CNES.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 21/05/2022
• Auteurs : Massimiliano GrecoThomas de CorteAri ErcoleMassimo AntonelliÉlie AzoulayGiuseppe CiterioAndrew Conway MorrisGennaro D. de PascaleFrantisek DuskaPaul ElbersSharon EinavLui ForniLaura GalarzaArmand GirbesGiacomo GrasselliVitaly GusarovAlasdair JubbJozef KeseciogluAndrea LavinioMaria Cruz Martin DelgadoJohannes MellinghoffSheila Nainan MyatraMarlies OstermannMariangela PellegriniPedro PovoaStefan SchallerJean-Louis TeboulAdrian WongJan de WaeleMaurizio CecconiMarco BezziAlicia GiraPhilipp EllerTarikul HamidInjamam Ull HaqueWim de BuyserAntonella CudiaDaniel de BackerPierre FoulonVincent CollinJan de WaeleJolien van HeckeElisabeth de WaeleClaire van MalderenJean-Baptiste MeslandPatrick BistonMichael PiagnerelliLionel HaentjensNicolas de SchryverJan van LeemputPhilippe VanhovePierre BulpaViktoria IlievaDavid KatzAlexandra BinnieAnna GeageaFernando TirapeguiGustavo LagoJerónimo GrafRodrigo Perez-AraosPatricio VargasFelipe MartinezEduardo LabarcaDaniel Molano FrancoDaniela Parra-TanouxLuis Felipe ReyesDavid YepesFilip PerišSanda Stojanović StipićCynthia Vanessa Campozano BurgosPaulo Roberto Navas BoadaJose Luis Barberan BrunJuan Pablo Paredes BallesterosGamal AbdelnasserAhmed HammoudaOmar ElmandouhAhmed AzzamAliae Mohamed HusseinIslam GalalAhmed AwadMohammed AzabMaged AbdallaHebatallah AssalMostafa AlfishawySherief GhozySamar TharwatAbdullah EldalyAnneli EllerveeVeronika ReinhardAnne ChrismentChrystelle PoyatJulio BadieFernando Berdaguer FerrariBjörn WeissClara SchellenbergJulius GrunowMarco LorenzStefan SchallerPeter SpiethMarc BotaFalk FichtnerKristina FuestTobias LahmerJohannes HerrmannPatrick MeybohmNikolaos MarkouGeorgia VasileiadouEvangelia ChrysanthopoulouPanagiotis PapamichalisIoanna SoultatiSameer JogKushal KalvitSheila Nainan MyatraIvan KrupaAisa TharwatAlistair NicholAine MccarthyAta MahmoodpoorTommaso TonettiPaolo IsoniSavino SpadaroCarlo Alberto VoltaLucia MirabellaAlberto NotoGaetano FlorioAmedeo GuzzardellaChiara PaleariFederica BaccanelliMarzia SaviMassimo AntonelliGennaro de PascaleSan LucaBarbara VaccariniGiorgia MontrucchioGabriele SalesKatia DonadelloLeonardo GottinMarta NizzeroEnrico PolatiSilvia de RosaDemet SulemanjiAbdurraouf AbusalamaMuhammed ElhadiMontelongo de FelipejesusDaniel Rodriguez GonzalezVictor Hugo Madrigal RoblesNancy CanedoAlejandro Esquivel ChavezTarek DendaneBart GradyBen de JongEveline van der HeidenPatrick ThoralBas van den BogaardPeter SpronkSefanja AchterbergMelanie GroeneveldRalph SoCalvin de WijsHarm ScholtenAlbertus BeishuizenAlexander CornetAuke ReidingaHetty KranenRoos MensinkSpaarne GasthuisSylvia den BoerMarcel de GrootOliver BeckCarina BethlehemBas van BusselTim FrenzelCelestine de JongRob WiltingJozef KeseciogluJannet Mehagnoul-SchipperDatonye AlasiaAshok KumarAhad QayyumMuhammad RanaMustafa Abu JayyabRosario Quispe SierraAaron Mark HernandezJosé de AlmeidaLúcia TabordaMónica AnselmoTiago RamiresCatarina SilvaCarolina RorizRui MoraisPedro PóvoaPatricia PatricioAndré PintoMaria Lurdes SantosVasco CostaPedro CunhaCelina GonçalvesSandra NunesJoão CamõesDiana AdriãoAna OliveiraAli OmraniMuna Al MaslamaniAbdurrahmaan Suei ElbuzidiBara Mahmoud Al QudahAbdel Rauof AkkariMohamed AlkhattebAnas BaiouAhmed HusainMohamed AlwraidatIbrahim Abdulsalam SaifDana BakdachAmna AhmedMohamed AleefAwadh BintaherCristina PetrisorEvgeniy PopovKsenia PopovaMariia DementienkoBoris TeplykhAlexey PyregovLiubov DavydovaBelskii VladislavElena NeporadaIvan ZverevSvetlana MeshchaninovaDmitry SokolovElena GavrilovaIrina ShlykIgor PoliakovMarina VlasovaOhoud AljuhaniAmina AlkhalafFelwa Bin HumaidYaseen ArabiAhmed KuhailOmar ElrabiMadihah GhannamNg Teng FongAmit KansalVui Kian HoJensen NgRaquel Rodrígez GarcíaXiana Taboada FragaMª del Pilar García-BonilloAntonio Padilla-SerranoMarta Martin CuadradoCarlos FerrandoIgnacio Catalan-MonzonLaura GalarzaFernando Frutos-VivarJorge JimenezCarmen Rodríguez-SolisEnric Franquesa-GonzalezGuillermo Pérez AcostaLuciano Santana CabreraJuan Pablo Aviles ParraFrancisco Muñoyerro GonzalezMaria del Carmen Lorente ConesaIgnacio Yago Martinez VarelaOrville Victoriano Baez PraviaMaria Cruz Martin DelgadoCarlos Munoz de CaboAna-Maria IoanCesar Perez-CalvoArnoldo SantosAne Abad-MotosJavier Ripolles-MelchorBelén Civantos MartinSantiago Yus TeruelJuan Higuera LucasAaron Blandino OrtizRaúl de Pablo SánchezJesús Emilio Barrueco-FrancioniLorena Forcelledo EspinaJosé Bonell-GoytisoloIñigo SalaverriaAntonia Socias MirEmilio Rodriguez-RuizVirginia Hidalgo ValverdePatricia Jimeno CuberoFrancisca Arbol LindeNieves Cruza LeganesJuan Maria RomeuPablo ConchaJosé Angel Berezo-GarciaVirginia FraileCristina Cuenca-RubioDavid Pérez-TorresAinhoa SerranoClara Martínez ValeroAndrea Ortiz SunerLeire LarrañagaNoemi LegaristiGerardo FerrignoSafa KhlafallaRosita Bihariesingh-SanchitHallands SjukhusFrank ZoernerJonathan GripKristina KilsandJohan MårtenssonJonas ÖsterlindAkademiska SjukhusetMagnus von SethVästerviks SjukhusJohan BerkiusSamuele CerutiAndrea GlottaSeval IzdesIşıl Özkoçak TuranAhmet CosarBurcin HalacliNecla DereliMehmet YilmazTürkay AkbasGülseren ElaySelin EyüpoğluYelíz BílírKemal Tolga SaraçoğluEbru KayaAyca Sultan SahinPervin Korkmaz EkrenTuğçe MengiKezban Ozmen SunerYakup TomakAhmet ErogluAsad AlsabbahKatie HanlonKevin GervinSean McmahonSamantha HaganCaroline HigenbottamRandeep MullhiLottie PoultonTomasz TorlinskiAllen GarethNick TrumanGopal VijayakumarChris HallAlasdair JubbLenka CagovaNicola JonesSam GrahamNicole RobinAmanda CowtonAdrian DonnellyNatalia SingatullinaMelanie KentCarole BoulangerZoë CampbellElizabeth PotterNatalie DuricTamas SzakmanyRoyal BromptonOrinta KviatkovskeNandor MarczinCaroline EllisRajnish SahaChunda Sri-ChandanaJohn AllanLana MumeljHarish VenkateshVera Nina GotzAnthony CochraneBarbara FicialShruthi KambleNuttha LumlertgulChristopher OddySusan JainGiulia Beatrice CrapelliAikaterini VlachouDavid GoldenSweyn GarriochJeremy HenningGupta LoveleenaMiriam DaveyLina GrauslyteErika Salciute-SimeneMartin CookDanny BarlingPhil BroadhurstSarah PurvisMichael SpiveyBenjamin ShukerIrina GrecuDaniel HardingNatalia SingatullinaJames DeanNathan NielsenSama Al-BayatiMohammed Al-SadawiMariane CharronPeter StubenrauchJairo SantanillaCatherine WentowskiDorothea RosenbergerPolikseni EksarkoRandeep Jawa
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal Università degli Studi di Milano-Bicocca = University of Milano-Bicocca Shaare Zedek Medical Center [Jerusalem, Israel] VU University Medical Center [Amsterdam] Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico Università degli Studi di Milano = University of Milan Hypertension pulmonaire : physiopathologie et innovation thérapeutique
• Publié dans Intensive Care Medicine le 27/10/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 20/05/2022
• Auteurs : Isabelle BertrandPhilippe FlatresseGuillaume BesnardJean-Marc BethouxZdenek ChalupaChristophe PlantierMartin RackMassinissa NabetJean-Pierre RaskinFrederic Allibert
• Organismes : SOITEC SOITEC SOITEC SOITEC Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Université Catholique de Louvain = Catholic University of Louvain Université Catholique de Louvain = Catholic University of Louvain Université Catholique de Louvain = Catholic University of Louvain SOITEC
• Publié dans ECS Transactions le 25/10/2020

---

Résumé : FD-SOI CMOS technology is entering the mmWave realm, providing undeniable benefits in terms of data-rates, bandwidth, latency and power consumption improvements. The high resistivity substrate option is seen as a major booster to reach ultimate mmWave performances. The engineering challenges related to this new wafer generation are addressed in this paper. We will review benefits and drawbacks of each possible high resistivity material, and discuss process options to enhance performances on resistivity stability and mechanical robustness to deformation through fabrication processes. Specific measurements are presented to show that going from standard to high resistivity substrates did not impact the behaviour of logic devices. Those substrates being destined to RF and mmWave applications, their performance was also measured in terms of small signal response using coplanar waveguides.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 20/05/2022
• Auteurs : Arthur OrieuxAntonin BouchetAlice DoreilleLiliana PaslaruMarine LivrozetJean-Philippe HaymannNacera OualiLaurent MesnardEmmanuel LetavernierPierre Galichon
• Organismes : CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée CHU Tenon [AP-HP] Université Claude Bernard Lyon 1 CHU Tenon [AP-HP] CHU Tenon [AP-HP] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée CHU Tenon [AP-HP] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée CHU Tenon [AP-HP] CHU Tenon [AP-HP] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée
• Publié dans World Journal of Urology le 27/10/2020

---

Résumé : Purpose Living kidney donors (LKD) partially compensate the initial loss of glomerular filtration rate (GFR), a phenomenon known as renal functional reserve (RFR). RFR is reduced in the elderly, a population with increased prevalence of chronic kidney disease. We hypothesized that the selected, healthy population of LKD, would specifically inform about the physiological determinants of the RFR and studied it using measured GFR (mGFR). Methods We retrospectively analyzed pre-donation and post-donation mGFR in 76 LKD from Tenon Hospital (Paris, France) between 2002 and 2018. In addition to GFR measurements, we collected pre-donation morphologic parameters, demographic data, and kidney volumes. Results Mean pre-donation mGFR was 90.11 ± 12.64 mL/min/1.73 m 2 and decreased to 61.26 ± 9.57 mL/min/1.73 m 2 1 year after donation. Pre-donation mGFR correlated with age (p = 0.0003), total kidney volume (p = 0.0004) and pre-donation serum creatinine (p = 0.0453). Pre-donation mGFR strongly predicted 1-year post-donation mGFR. Mean RFR (increase in GFR of the remnant kidney between pre-donation and post-donation) was 36.67 ± 16.67% 1 year after donation. In the multivariate linear model, RFR was negatively correlated to total kidney volume (p = 0.02) but not with age or pre-donation serum creatinine. Conclusions We found that pre-donation mGFR decreases with age and identified low total kidney volume as a predictor of RFR in healthy individuals. This suggests an adaptative and reversible decrease in kidney function rather than age-related damage. Older subjects may have reduced metabolic requirements with subsequent reduction in glomerular filtration and kidney volume and preserved RFR. Therefore, low GFR in older subjects should not preclude kidney donation.

---

Fichiers liés : 2022-Orieux- World J Urol.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 18/05/2022
• Auteurs : Louis ThieryXavier CarleBenoit TestudGrégoire BoulouisMathieu Di BisceglieFarouk TradiAnthony ReyrePierre LehmannPhilippe Dory-LautrecJan-Patrick StellmannNadine GirardHerve BrunelJean-François Hak
• Organismes : Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
• Publié dans Journal of Neurointerventional Surgery le 26/10/2020

---

Résumé : Background Balloon-assisted mechanical angioplasty for cerebral vasospasm following aneurysmal subarachnoid hemorrhage (aSAH) has a number of limitations, including transient occlusion of the spastic blood vessel. Comaneci is an FDA-approved device for temporary coil embolization assistance which has recently also been approved for the treatment of distal symptomatic refractory vasospasm. We aimed to report the feasibility, efficacy and safety of our experience with Comaneci angioplasty for refractory distal vasospasm (up to the second segment of the cerebral arteries) following aSAH. Methods This is a retrospective analysis of a prospective series of 18 patients included between April 2019 and June 2021 with aSAH and symptomatic vasospasm refractory to medical therapy, who were treated using Comaneci-17-asssisted mechanical distal angioplasty. Immediate angiographic results, procedure-related complications, and clinical outcomes were assessed. Inter-rater reliability of the scores was determined using the intraclass correlation coefficient. Results Comaneci-assisted distal angioplasty was performed in 18 patients, corresponding to 31 target arteries. All distal anterior segments were easily accessible with the Comaneci-17 device. Vasospasm improvement after Comaneci mechanical angioplasty was seen in 22 distal arteries (71%) (weighted Cohen’s kappa (κ w ) 0.73, 95% CI 0.69 to 0.93). Vasospasm recurrence occurred in three patients (16.67%) and delayed cerebral infarction in three patients (16.67%), with a mean±SD delay between onset of symptoms and imaging follow-up (MRI/CT) of 32.61±8.93 days (κ w 0.98, 95% CI 0.88 to 1). Conclusion This initial experience suggests that distal mechanical angioplasty performed with the Comaneci-17 device for refractory vasospasm following aSAH seems to be safe, with good feasibility and efficacy.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 17/05/2022
• Auteurs : Sonia Etenna Lekana-DoukiNadine N'DilimabakaAnthony LevasseurPhilippe ColsonJulia Cyrielle AndekoOrnella Zong MinkoOctavie Banga Mve-EllaPierre-Edouard FournierChristian DevauxBertrand Mve OndoFalone Larissa AkombiLaurianne Yacka Mouele BoloAudrey Michel Ngonga DikongoAbdoulaye DianéArsène Mabika MabikaJenny Francine MathouetCresh DzemboNick Chenis AtigaAnicet Mouity MatoumbaNal Kennedy NdjangangoyeLudivine BréchardMarielle Bedotto-BuffetJoa Braithe Mangombi PambouMarisca Kandet YattaraElvire Anita Mbongo NkamaArmel Mintsa NdongAyola Akim AdegnikaDidier RaoultFlorence FenollarJean-Bernard Lekana-Douki
• Organismes : Centre International de Recherches Médicales de Franceville Centre International de Recherches Médicales de Franceville Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Centre National de la Recherche Scientifique Centre International de Recherches Médicales de Franceville Centre International de Recherches Médicales de Franceville Centre International de Recherches Médicales de Franceville Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Centre International de Recherches Médicales de Franceville
• Publié dans Frontiers in Medicine le 01/11/2020

---

Résumé : Since the onset of the COVID-19 pandemic, the SARS-CoV-2 viral dynamics in Africa have been less documented than on other continents. In Gabon, a Central African country, a total number of 37,511 cases of COVID-19 and 281 deaths have been reported as of December 8, 2021. After the first COVID-19 case was reported on March 12, 2020, in the capital Libreville, the country experienced two successive waves. The first one, occurred in March 2020 to August 2020, and the second one in January 2021 to May 2021. The third wave began in September 2021 and ended in November 2021. In order to reduce the data gap regarding the dynamics of SARS-CoV-2 in Central Africa, we performed a retrospective genotyping study using 1,006 samples collected from COVID-19 patients in Gabon from 2020 to 2021. Using SARS-CoV-2 variant screening by Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) and whole genome sequencing (WGS), we genotyped 809 SARS-CoV-2 samples through qRT-PCR and identified to generated 291 new genomes. It allowed us to describe specific mutations and changes in the SARS-CoV-2 variants in Gabon. The qRT-PCR screening of 809 positive samples from March 2020 to September 2021 showed that 119 SARS-CoV-2 samples (14.7%) were classified as VOC Alpha (Pangolin lineage B.1.1.7), one (0.1%) was a VOC Beta (B.1.351), and 198 (24.5 %) were VOC Delta (B.1.617.2), while 491 samples (60.7%) remained negative for the variants sought. The B1.1 variant was predominant during the first wave while the VOC Alpha dominated the second wave. The B1.617.2 Delta variant is currently the dominant variant of the third wave. Similarly, the analysis of the 291 genome sequences indicated that the dominant variant during the first wave was lineage B.1.1, while the dominant variants of the second wave were lineages B.1.1.7 (50.6%) and B.1.1.318 (36.4%). The third wave started with the circulation of the Delta variant (B.1.617). Finally, we compared these results to the SARS-CoV-2 sequences reported in other African, European, American and Asian countries. Sequences of Gabonese SARS-CoV-2 strains presented the highest similarities with those of France, Belgium and neighboring countries of Central Africa, as well as West Africa.

---

Fichiers liés : fmed-09-877391.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 16/05/2022
• Auteurs : Antoine MiniussiLaurent ArtolaFabrice BoustPablo CaronChristophe CoudrainDidier FalguèreOlivier GazzanoGuillaume GourvesKevin GrosselJean GuerardPierre-Emmanuel HaenslerFrançois IssacJulien JaeckVincent LebatVincent MagetJean-Charles Matéo-VelezDenis PackanYoann PaichardPhilippe PerraultHuy-Khang PhanArnaud PulignyWilfrid QuenumVéronique RannouBernard RosierLaurent Rousset-RouvièreJ.-F. SauvagePierre SimoneauSophie Thétas
• Organismes : DTIS, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université de Toulouse [Toulouse] DEMR, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DTIS, ONERA, Université de Toulouse [Toulouse] DEMR, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université Paris Saclay [Châtillon] DTIS, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université Paris Saclay [Châtillon] DPHY, ONERA, Université de Toulouse [Toulouse] DPHY, ONERA, Université de Toulouse [Toulouse] DPHY, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] DPHY, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université de Toulouse [Toulouse] DEMR, ONERA, Université Paris Saclay [Palaiseau] ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA [Salon-de-Provence] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau]

---

Résumé : ONERA has been working for the past few years in developing space systems oriented toward Cubesat technology. In collaboration with industrials, universities and research labs, ONERA is working on several cubesat missions with scientific and technological goals. Those include ionosphere study, radiation belts monitoring, earth observation and ESD mitigation systems. To feed these activities our teams also work on technological bricks such as deployable telescope, optical freeform designs and rad-hard digital core. Finally, unique test benches to validate designs sustaining the space environment (EMC, radiation, electrical propulsion, TVAC) complete our equipment. Such range of activities requires organization and strategy to provide necessary support to our teams and partners in order to complete our missions. The ONSATLab is dedicated to this purpose.

---

Fichiers liés : DTIS22139.pdf

---

Source