Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 20/01/2026
• Auteurs : Alexandre TronelMorgane Roger-MargueritatCaroline PlazySalomé BiennierAnthony CraspayIpsita MohantyStéphanie Cools PortierManolo LaiolaGuus RoeselersNicolas MathieuMarianne HupePieter C DorresteinJean-Pierre AlcarazDonald K MartinPhilippe CinquinAnne-Sophie SilventJoris GiaiMarion ProustThomas SoranzoElena BuelowAudrey Le Gouellec
• Organismes : Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational microbial Evolution and Engineering Translational microbial Evolution and Engineering Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational microbial Evolution and Engineering CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble MaaT Pharma [Lyon] MetaGenoPolis Danone Nutricia Research [Utrecht] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Université de Genève = University of Geneva University of California [San Diego] Danone Research Skaggs School of Pharmacy and Pharmaceutical Sciences [San Diego] Collaborative Mass Spectrometry Innovation Center Colorado State University [Fort Collins] Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Université Grenoble Alpes Systèmes Nanobiotechnologiques et Biomimétiques Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 SIC Centre d'Investigation Clinique [Grenoble] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Modélisation et Évaluation des données complexes en Santé Publique Centre d'Investigation Clinique [Grenoble] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble Translational microbial Evolution and Engineering Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational microbial Evolution and Engineering Translational microbial Evolution and Engineering Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble
• Publié dans ISME Communications le 28/09/2021

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Résumé :

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Fichiers liés : ycaf224.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/01/2026
• Auteurs : Jeanne TamarelleMaria V DoriaValérie RambolamananaTatamo RajaonarivoAna Sousa FerreiraMaheninasy RakotondrainipianaRindra Vatosoa RandremananaPhilippe J SansonettiPascale VonaeschRobert BaroukiAlexandra BastaraudJean-Marc CollardMaria V DoriaDarragh DuffyB. Brett FinlaySerge Ghislain DjorieTamara Giles-VernickBolmbaye Privat GondjeJean-Chrysostome GodyMilena HasanNathalie KapelJean-Pierre LombartSynthia Nazita NigatoloumLaura Wegener ParfreyMaheninasy RakotondrainipianaRindra Vatosoa RandremananaAnnick RobinsonPierre-Alain RubboLaura SchaefferIonela Gouandjika-VasilacheSonia Sandrine VondoInès Vigan-Womas
• Organismes : Université de Lausanne = University of Lausanne Institut Pasteur [Paris] Institut Pasteur de Madagascar Institut Pasteur de Madagascar Universidade de Lisboa = University of Lisbon = Université de Lisbonne [Lisboa] Instituto Universitário de Lisboa Institut Pasteur de Madagascar Institut Pasteur de Madagascar Pathogénie microbienne moléculaire Université de Lausanne = University of Lausanne Hôpital Necker - Enfants Malades [AP-HP] Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur [Paris] Institut Pasteur [Paris] University of British Columbia [Canada] Institut Pasteur de Bangui Institut Pasteur [Paris] Centre pédiatrique de Bangui Centre pédiatrique de Bangui Institut Pasteur [Paris] CHU Pitié-Salpêtrière [AP-HP] Institut Pasteur de Bangui Centre pédiatrique de Bangui University of British Columbia [Canada] Institut Pasteur de Madagascar Institut Pasteur de Madagascar Centre Hospitalier Universitaire Mère-Enfant de Tsaralalàna Institut Pasteur de Bangui Institut Pasteur [Paris] Institut Pasteur de Bangui Centre pédiatrique de Bangui Institut Pasteur de Madagascar
• Publié dans Scientific Reports le 26/10/2020

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Résumé : In 2024, stunted child growth affected 150 million children under the age of five years, underscoring its critical impact on global health. Stunting has also been associated with neurodevelopmental delays. This study explores the relationship between stunting, the fecal microbiota, and neurodevelopment in 2–5-year-old children from the Afribiota cross-sectional study in Madagascar. Children were assessed using the Ages and Stages Questionnaire (ASQ-3), covering five developmental domains (communication, personal-social, problem-solving, fine and gross motor). Fecal samples were analyzed via 16S rRNA gene amplicon sequencing. Classical bi- and multivariate analysis was combined with Structural Equation Modelling to evaluate direct and indirect associations between different clinical factors, the microbiota and neurodevelopment. Our study shows that stunting and low socioeconomic status are consistently linked to poorer neurodevelopmental outcomes, while low branched-chain amino acids and hemoglobin levels are associated with stunting. Furthermore, a higher microbial diversity within individuals (α-diversity—specifically the Shannon index-) was directly linked to improved neurodevelopment scores in one of the tested models, while gut microbiota variation between individuals (β-diversity) was not associated with neurodevelopment. These findings support the hypothesis of neurodevelopment being primarily influenced by nutritional and social factors, with a more limited role for microbiota diversity.

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Fichiers liés : s41598-026-35174-5_reference.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2026
• Auteurs : Anaïs SchavgoulidzeAurore PerrotXavier LeleuTitouan CazaubielMarie-Lorraine ChretienPierre FeugierKarim BelhadjSalomon ManierMurielle RousselSabine BrechignacFrédérique Orsini-PiocelleMohamad MohtyJean Marc Schiano de ColellaMargaret MacroDidier AdikoMamoun DibJean FontanCarine Luttiau-MotardDidier BouscaryLaurent PascalVirginie RolandFrançois LifermannJana BakalaLydia MontesCéline KennelPhilippe ReyValentine RichezFaiza KeddarLaurent FrenzelClaire CalmettesCarine ChaleteixIsabelle PlantierÉmilie ChalayerAnna SchmittChristophe RoulHélène DemarquetteChloé CeruttiLuka PavageauLaure DerrierHervé Avet-LoiseauJill Corre
• Organismes : Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU de Bordeaux Pellegrin [Bordeaux] Service d'hématologie biologique [CHU de Dijon] Centre Hospitalier Régional Universitaire de Nancy CHU Henri Mondor [Créteil] Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 CHU Limoges Service d'hématologie clinique [Avicenne] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] CHU Saint-Antoine [AP-HP] Institut Paoli-Calmettes CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Libourne Hôpital Haut-Lévêque [CHU Bordeaux] Centre Hospitalier Universitaire d'Angers Hôpital Jean Minjoz [Besançon] Institut Cochin Hôpital Saint Vincent de Paul [Lille] Centre Hospitalier Dax - Côte d'Argent Centre Hospitalier de Lens CHU Amiens-Picardie Service d'Accompagnement et Soins Palliatifs [CHU Limoges] Centre Léon Bérard [Lyon] Imagine - Institut des maladies génétiques (IHU) Centre Hospitalier de Périgueux CHU Clermont-Ferrand Hôpital Victor Provo [Roubaix] U 1059 – SAINBIOSE Bio-ingénierie Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] Institut de Cancérologie et d'Hématologie Universitaire de Saint-Étienne [CHU Saint-Etienne] Institut Bergonié [Bordeaux] Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Hôpital Claude Huriez [Lille] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse]
• Publié dans Blood le 28/10/2020

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Résumé : The prognostic heterogeneity of multiple myeloma is mainly driven by the genomic features of myeloma cells. The International Myeloma Society (IMS)/International Myeloma Working Group (IMWG) recently proposed a high-risk (HR) genomic model to have a consensus definition of genomic risk. We performed next-generation sequencing in the form of a panel on samples from 6528 patients with newly diagnosed multiple myeloma (NDMM) and 1583 patients at first relapse between 2019 and 2024. We observed that 22.4% of patients at diagnosis and 36.7% of patients at first relapse were classified as high risk according to the Consensus Genomic Staging. Clinical data were available for 2695 patients at diagnosis. After a median follow-up of 35 months, the median progression-free survival (PFS) was 30 months for patients with HR NDMM and 51 months for standard-risk (SR) patients (P< .0001). The HR cytogenetic criteria from the Revised- International Staging System score were not able to differentiate between HR and SR patients based on the IMS/IMWG genomic subgroups. Looking at each criterion independently, we found that the presence of del(17p), TP53 mutation, biallelic del(1p32), or the combination of intermediate-risk cytogenetics (gain 1q, del(1p32), t(4;14), t(14;16), t(14;20)) significantly reduced the PFS when compared with SR patients. Moreover, patients with several cumulating criteria had an even worse prognosis. Among SR patients, classified according to the genomic definition with normal creatinine, the median PFS for those with high β2-microglobulin was not significantly different from that of patients with normal β2-microglobulin level. This study validated the IMS/IMWG genomic definition of HR myeloma in a large cohort of patients diagnosed from 2019 onwards.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2026
• Auteurs : Ryma BenrabahÉmilien GirotJean-Marc CommengeRené FournetPhilippe ArnouxPierre-Alexandre GlaudeBaptiste Sirjean
• Organismes : Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Département de Chimie Physique des Réactions Laboratoire Réactions et Génie des Procédés
• Publié dans Chemical Engineering Science le 29/10/2020

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Résumé : Liquid phase oxidation reactions are widely studied and optimized for industrial processes of interest such as the oxidation of cyclohexane. The slow oxidation of hydrocarbons, which takes place throughout their chain of use, is the cause of fuel deterioration known as fuel ageing. In recent years, the use of microfluidic tools for the investigation of such processes is expanding with the development of the technologies. Microfluidics enables the use of explosive conditions in a safer way than traditional processes and these tools can be adapted for the kinetic study of the oxidation of ground fuels and jet fuels. Their kinetics of oxidation are slow, and their study requires long residence times, which are not usually reached in the microfluidic field. The PEEK-ACHU rig, a microfluidic device with a heated silicon/glass microfluidic reactor designed for long residence times (from 16 min up to 230 min) and high pressure (up to 40 bar), was developed for the study of slow oxidation reactions of organic compounds. This work presents the design of the reactor and proposes a hydrodynamic study of the gas-liquid Taylor flow implemented in this tool to enable the study of oxidation reactions of fuels. A good understanding of the different diphasic flow regimes as a function of gas bubble generation was obtained for conditions in the explosive range. A correlation was found between the density and viscosity of a fuel and the length of gas bubbles and liquid slugs. The thickness of the residual liquid film at the wall and the reaction regime were characterized and demonstrate that the design of our microreactor enables the kinetic study of organic compounds oxidation, without oxygen mass transfer limitations, at high temperature and high pressure, for very long residence times.

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Fichiers liés : microfluidic_article_R1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/01/2026
• Auteurs : Boris YavkinKin On HoLaura HenryNicolas GuignotMarie-Pierre AdamPhilippe GoldnerFabien J BénédicJean-François RochMary de Feudis
• Organismes : Laboratoire Lumière, Matière et Interfaces Laboratoire Lumière, Matière et Interfaces Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire Lumière, Matière et Interfaces Institut de Recherche de Chimie Paris Laboratoire des Sciences des Procédés et des Matériaux Laboratoire Lumière, Matière et Interfaces Institut de Recherche de Chimie Paris CY Cergy Paris Université Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL

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Résumé : Group-IV color centers in nanodiamond, such as silicon-vacancy (SiV) defects, are promising quantum emitters for sensing and photonics due to their bright and narrow zero-phonon line (ZPL) emission, representing up to 80% of their total luminescence [1–3]. However, in as-grown CVD nanodiamonds, residual lattice strain induces significant spectral broadening, preventing access to the fine electronic structure of SiV centers even at cryogenic temperatures. To mitigate this effect, we carried out a controlled high-pressure and high-temperature (HPHT) annealing process using the Paris–Edinburgh press, performed in situ at the PSICHE beamline of Synchrotron SOLEIL [4]. The synchrotron X-ray diffraction and tomography measurements were crucial for the precise calibration of pressure and temperature conditions within the assembly, enabling us to finely tune the HPHT parameters to promote strain relaxation while avoiding the onset of graphitization. These in situ synchrotron investigations provided real-time insight into nanodiamond phase stability and strain-release mechanisms, which were confirmed ex situ by optical measurements, leading to the first observation of resolved fine-structure transitions in SiV centers after HPHT treatment. Importantly, the calibrated HPHT setup can now be reliably operated off-beam, enabling systematic post-annealing studies on different types of nanodiamonds and color centers. This methodology establishes a robust experimental reference for future off-beam HPHT annealing treatments and serves as a benchmark for the broader quantum diamond research community. REFERENCES 1. T. Muller et al., Nat. Commun. 5, 3328 (2014). 2. M. De Feudis et al., Adv. Mater. Interfaces 7, 1901408 (2019). 3. B. Vindolet et al., Phys. Rev. B 106, 214109 (2022). 4. L. Henry et al., J. Synchrotron Rad. 29, 853-861 (2022).

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 14/01/2026
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangHeng YangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong WangJin WangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuChengjun YuGerry BauerZhipeng CuiBolin LiHui WangKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouChristos LeonidouCharalambos NicolaouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinYasser AssranBasma El-MahdyAhmad LotfyMohammed MahmoudKarl EhatahtMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniErik BrückenAnna MilievaKenneth OsterbergMikko VoutilainenFrancisco Ignacio Garcia FuentesPatin InkaewKimmo Tuomas Samuli KallonenRavindra Kumar VermaTapio LampénKati Lassila-PeriniBettina LehtelaSami LehtiTomas LindénNestor Raul Mancilla XintoMikael MyllymäkiMilla-Maarit RantanenSanteri SaariokariNico Timothy ToikkaJorma TuominiemiNurfikri Bin NorjoharuddeenHenning KirschenmannPanja-Riina LuukkaHenri PetrowMarc BesanconFabrice CoudercMarc DejardinDaniel DenegriPaul DevougeJean-Louis FaureFederico FerriPaul GaigneSerguei GanjourPhilippe GrasGautier Hamel de MonchenaultMintu KumarVictor LohezicYuliia MaidannykJulie MalclesFrancesco OrlandiLouis PortalesSamuele RonchiMehmet Özgür SahinAurore Savoy-NavarroPolina SimkinaMaksym TitovMarta TornagoRuth Amella RanzFlorian BeaudetteGiacomo BoldriniPhilippe BussonClaude CharlotMarco ChiusiTheo Damien CuissetOlivier DavignonAdinda de WitTrisha DebnathIsaac Telford EhleShamik GhoshAndrew GilbertRaphael Granier de CassagnacLida KalipolitiMartina ManoniMatthew NguyenStepan ObraztsovChristophe OchandoRoberto SalernoJean-Baptiste SauvanYves SiroisGamze SokmenLourdes Urda GómezAlexandre ZabiAmina ZghicheJean-Laurent AgramJeremy AndreaDaniel BlochJean-Marie BromEric Christian ChabertCaroline CollardGael CoulonSaskia FalkeUlrich GoerlachRaphael HaeberleAnne-Catherine Le BihanMeena MeenaOcéane PoncetGourab SahaPaul VaucelleAdriano Di FlorioDavid AmramStephanie BeauceronBenjamin BlanconGaelle BoudoulNicolas ChanonDidier ContardoPierre DepasseHoumani El MamouniJean FaySusan GasconMaxime GouzevitchChristopher GreenbergGérald GrenierBernard IlleElise Jourd'HuyMorgan LethuillierBenjamin MassoteauLaurent MirabitoArnab PurohitMuriel Vander DoncktJie XiaoGeorge AdamovIrakli LomidzeZviad TsamalaidzeValeria BottaSandra Consuegra RodríguezLutz FeldKatja KleinMartin LipinskiDanilo MeuserPhilipp NattlandVanessa OppenländerAlexander PaulsDanyer Pérez AdánNicolas RöwertMarius TeroerdeCaio DaumannSvenja DiekmannAlena DodonovaNiclas EichDmitry EliseevFrederic EngelkeJohannes ErdmannMartin ErdmannBenjamin FischerThomas HebbekerKerstin HoepfnerFrancesco IvoneAlexander JungNitish KumarMing-Yan LeeFlorian MausolfMarkus MerschmeyerArnd MeyerFabian NowotnyAndrey PozdnyakovWahid RedjebHans ReithlerUttiya SarkarValentina SarkisoviAlexander SchmidtChinmay SethArchana SharmaJan Lukas SpahValentyn VaulinShawn ZaleskiMax Romain BeckersChristian DziwokGünter FlüggeNina HoeflichThomas KressAndreas NowackOliver PoothAchim StahlAlexander ZotzHenriette Aarup PetersenAenne AbelMaria Aldaya MartinJuliette AlimenaSimone AmorosoYing AnIakov AndreevJorn BachSamuel BaxterMaryam BayatmakouHugo Becerril GonzalezOlaf BehnkeAlberto BelvedereFreya BlekmanKerstin BorrasAlan CampbellSuman ChatterjeeLucia Ximena Coll SaraviaGuenter EckerlinDoris EcksteinElisabetta GalloAchim GeiserValentina GuglielmiMoritz GuthoffAndreas HinzmannLaurids JeppeMatthias KasemannClaus KleinwortRoman KoglerMatthias KommDirk KrückerWolfgang LangeDaina Leyva PerniaKuan-Yu LinKaterina LipkaWolfgang LohmannJacopo MalvasoRainer MankelIsabell-Alissandra Melzer-PellmannMikel Mendizabal MorentinAndreas Bernhard MeyerGabriele MilellaKeila Moral FigueroaAndreas MussgillerLakshmi Priya NairJeremi NiedzielaAndreas NürnbergJiwon ParkEvan RankenAlexei RasperezaDaniil RastorguevLovisa RygaardMoritz SchamSimon SchnakePaul SchützeChristian SchwanenbergerDaria SelivanovaKonstantin SharkoMykyta ShchedrolosievDominic StaffordMatin TorkianFederico VazzolerAna Ventura BarrosoRoberval WalshDi WangQun WangKatarzyna WichmannLucas WiensChristoph WissingYewon YangStepan ZakharovAndré Zimermmane Castro SantosAna Rita Alves AndradeMassimiliano AntonelloSven BollwegMatteo BonanomiKarim El MorabitYannick FischerMathis FrahmErika GaruttiAlexander GrohsjeanAyse Asu GuvenliJohannes HallerDaniel HundhausenGregor KasieczkaPhilip KeicherRobert KlannerWilliam KorcariTobias KramerChin-Chia KuoFinn LabeJohannes LangeArtur LobanovLouis MoureauxAliya NigamovaKonstantinos NikolopoulosAlexander PaaschKarla Josefina Pena RodriguezNathan ProuvostBianca RacitiMarcel RiegerDaniel SavoiuPeter SchleperMatthias SchröderJoern SchwandtManuel SommerhalderHartmut StadieGeorg SteinbrückRobert WardBogdan WiederspanMoritz WolfSebastian BrommerErik ButzYi-Mu ChenThorsten ChwalekAlexander DierlammGizem Gul DincerUmut ElicabukNils FaltermannManuel GiffelsArtur GottmannFrank HartmannMaximilian HorzelaFabian HummerUlrich HusemannJan KieselerMarkus KluteRufa Kunnilan Muhammed RafeekOlha LavorykJay Mathew LawhornAdelina LintuluotoStefan MaierMichele MormileThomas MüllerEmanuel PfefferMatteo PresillaGunter QuastKlaus RabbertzBrendan RegneryRalf SchmiederNikita ShadskiyIvan ShvetsovHans-Jürgen SimonisLars SowaLea StockmeierKomal TauqeerMaria TomsBogdan TopkoNicolò TrevisaniCedric VerstegeTim VoigtländerRalf Florian von CubeJost von den DrieschMichael WassmerRoger WolfWolfram Dietrich ZeunerXunwu ZuoGeorgios AnagnostouGeorgios DaskalakisAristotelis KyriakisGeorgios MelachroinosZacharias PainesisIoannis ParaskevasNiki SaoulidouKonstantinos TheofilatosEirini TziaferiEftychia TzovaraKonstantinos VellidisIlias ZisopoulosTheodoros ChatzistavrouGeorgia KarapostoliKonstantinos KousourisEirini SiamarkouGeorgios TsipolitisIoannis BestintzanosIoannis EvangelouCostas FoudasPanagiotis KatsoulisPanagiotis KokkasPolidamas Georgios Kosmoglou KioseoglouNikolaos ManthosIoannis PapadopoulosJohn StrologasDmitry DruzhkinCsaba HajduDezso HorvathKrisztina MártonAttila József RádlFerenc SiklerViktor VeszpremiMate CsanadKrisztián FarkasAnna FehérkutiMahmod Moussa Abdelkhalek GadallahÁrmin KadlecsikMoisés León CoelloGabriella PasztorGabor Istvan VeresBalazs UjvariGyula ZiliziGyorgy BenczeSandor CzellarJozsef MolnarZoltan SzillasiTamas Ferenc CsorgoFrigyes NemesTamas NovakIstvan SzanyiSunil BansalSuman Bala BeriVipin BhatnagarGeetanjali ChaudharySushil ChauhanNitish DhingraAmandeep KaurAnureet KaurHarjot KaurManjit KaurSunil KumarTanvi SheokandJasbir SinghAayushi SinglaAshutosh BhardwajArjun ChhetriBrajesh C ChoudharyAshok KumarArun KumarMohammad NaimuddinSaumya PhorKirti RanjanMahesh Kumar SainiShriniketan 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SwartzAndrés AbreuLuis Fernando Alcerro AlcerroJustin AnguianoSaray Arteaga EscatelPhilip BaringerAlice BeanRajarshi BhattacharyaZachary FlowersDerek GroveJack KingGeorgios KrintirasMargaret LazarovitsCole Le MahieuJuan MarquezMichael MurrayMatthew NickelSorina PopescuChristopher RoganChristophe RoyonSahithi RudrabhatlaStephen SandersCaleb SmithGraham WilsonBraden AllmondNaila IslamAndrew IvanovKetino KaadzeYurii MaravinJames NatoliGujju Gurunadha ReddyDennis RoyGiulia SorrentinoDrew BadenAlberto BelloniJoshua Bistany-RiebmanSarah Catherine EnoNicholas John HadleyShabnam JabeenRichard G KelloggTimothy KoethBraden KronheimSamuel LascioPéter MajorAlice MignereyChristopher PalmerChristos PapageorgakisMekhala Mahesh ParanjpeElena PopovaAlexey ShevelevLicheng ZhangCristian Baldenegro BarreraHannah BossiSamuel Bright-ThonneyIvan Amos CaliYu-Chen ChenPin-Chun ChouMariarosaria d'AlfonsoJan EysermansChad FreerGuillelmo Gomez CeballosMaxim GoncharovGaia GrossoPhilip HarrisDuc HoangGian Michele InnocentiKirill IvanovDmytro KovalskyiJeffrey KrupaLuca LavezzoYen-Jie LeeKenneth LongChristopher McginnAndrzej NovakMary Isabelle ParkChristoph PausChristina ReisselChristof RolandGunther RolandSimon RothmanTzu-An ShengGeorge StephansDavid WalterZhangqier WangBolek WyslouchTianyu YangBryan CrossmanWilliam James JacksonCharles KapsiakMichael KrohnDevin MahonJeremy MansBadder MarzocchiRoger RusackOnuray SancarRohith SaradhyNadja StrobbeKenneth BloomDaniel R ClaesGrace HazaJahid HossainChangwoo JooIlya KravchenkoAman RohillaJoaquin Emilo SiadoWilliam TabbAntonio VagneriniAndrew WightmanFurong YanHirak BandyopadhyayLauren HayHsin-Wei HsiaIa IashviliAlexis KalogeropoulosAvto KharchilavaAritra MandalMargaret MorrisDuong NguyenSalvatore RappoccioHaifa Rejeb SfarAc WilliamsPeter YoungDavid YuGeorge AlversonEmanuela BarberisJohan BonillaBen BylsmaMattia CampanaJohn DervanYacine HaddadYixiao HanIsrar IsrarAmrutha KrishnaMeng LuNicholas ManganelliRyan MccarthyDavid Michael MorseToyoko OrimotoLouise SkinnariCort Stewart ThoresonEmily TsaiDarien WoodSusan DittmerKristian Allan HahnMichael McginnisYulun MiaoDavid Gabriel MonkMichael Henry SchmittAngela TaliercioMayda VelascoJinglu WangGarvita AgarwalReyer BandRachael BucciSergi CastellsAbhishek DasAmanda EhnisReza GoldouzianMichael HildrethKenyi Hurtado AnampaTodor IvanovColin JessopAnton KarneyeuKevin LannonJohn LawrenceNikitas LoukasDylan LuttonJoseph MarianoNancy MarinelliIan McalisterThomas MccauleyChristopher McgradyConnor MooreYuri MusienkoHannah NelsonMarc OshersonAndrea PiccinelliRandy RuchtiAustin TownsendYuyi WanMitchell WayneHenry YockeyAashwin BasnetMichael CarriganRyan de los SantosLloyd Stanley DurkinChristopher HillMatthew JoyceMartha Nunez OrnelasDerek Albert WenzlBrian L WinerBrent YatesHichem BouchamaouiGage DezoortPeter ElmerAndre FrankenthalMassimiliano GalliBennett GreenbergNicholas HaubrichKiley KennedyGillian KoppYihui LaiDavid LangeAndrew LoeligerDaniel MarlowIsabel OjalvoJames OlsenFarrah SimpsonDavid SticklandChristopher TullySudhir MalikRicha SharmaSoumik ChandraRidhi ChawlaAn GuLaszlo GutayMatthew JonesAndreas Werner JungDmitry KondratyevMiaoyuan LiuGiulia NegroNorbert NeumeisterGaryfallia PaspalakiStefan PiperovNihar Ranjan SahaJan-Frederik SchulteFuqiang WangAndrew WildridgeWei XieYao YaoYibo ZhongNeeti ParasharAtanu PathakElton ShumkaDarin AcostaAman AgrawalCollin ArbourTaylor CarnahanPallabi DasKarl Matthew EcklundSarah FreedFrank J.M GeurtsTao HuangIason KrommydasNicole LewisWei LiJiazhao LinOsvaldo Miguel ColinBrian Paul PadleyRadia RedjimiJohn RotterMeutia WulansatitiEfe YigitbasiYousen ZhangOlga Bessidskaia BylundArie BodekPawel de BarbaroRegina DeminaAran Garcia-BellidoHonor Suzanne HareOtto HindrichsNukulsinh ParmarPavel ParyginHyonsan SeoRhys TausBrandon ChiaritoJohn Paul ChouSteven Vincent ClarkSean DonnellyDivya GadkariYuri GershteinEva HalkiadakisConnor HoughtonDavid JaroslawskiAdam KobertSotiroulla KonstantinouIan LaflotteAmitabh LathJordan MartinsMaximilian Perez PradaBenjamin RandJoseph ReichertPrafulla SahaSevil SalurSteve SchnetzerSunil SomalwarRobert StoneSteffie Ann ThayilScott ThomasJay VoraDaniel AllyAndrés G DelannoySara FiorendiJesse HarrisTova HolmesAnkush Reddy KanugantiNimmitha KarunarathnaJohn LawlessLawrence LeeEmery NibigiraBrandi SkipworthStefan SpanierDevin AebiMuhammad AhmadTowsifa AkhterKonstantin AndrosovArtem BolshovOthmane BouhaliAntimo CagnottaValeria d'AmanteRicardo EusebiPatrick FlanaganJason GilmoreYumeng GuoTeruki KamonSifu LuoRyan MuellerAlexei SafonovNural AkchurinJordan DamgovYongbin FengNiramay GogateYelbir KazhykarimKamal LamichhaneSung Won LeeChristopher MadridAaron MankelTimo PeltolaIgor VolobouevEric AppeltYi ChenSenta GreeneAlfredo GurrolaWillard JohnsRaghav Kunnawalkam ElayavalliAndrew MeloDenis RathjensFrancesco RomeoPaul SheldonShengquan TuoJulia VelkovskaJussi ViinikainenJingyu ZhangBryan CardwellHeewon ChungBradley CoxJohn HakalaGabriela Hamilton Ilha MachadoRobert HiroskyMaria JoseAlexander LedovskoyCristina MantillaChristopher NeuClara Ramón ÁlvarezZhenyu WuSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaShivani LomteRichard LovelessAbhishikth MallampalliAbdollah MohammadiSusmita MondalTrevor NelsonGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiRuslan ChistovMikhail DanilovTatyana DimovaAlexander ErshovSergei GninenkoIlya GorbunovAndrey GribushinAlexey KamenevVladimir KarjavineMikhail KirsanovVyacheslav KlyukhinOlga KodolovaVladimir KorenkovIurii KorsakovAleksei KozyrevNikolai KrasnikovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoSergey PolikarpovOlesia RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenKirill SlizhevskiyVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinAnatoli ZarubinIlia ZhizhinLev DudkoVictor KimVictor MurzinVadim OreshkinDmitry SosnovEdouard BoosViacheslav BunichevMikhail DubininViktor SavrinAlexander Snigirev
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon

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Résumé : This paper presents a combination of searches for the nonresonant production of Higgs boson pairs (HH) in proton-proton collisions at a centre-of-mass energy of 13 TeV. The data set was collected by the CMS experiment at the LHC from 2016 to 2018 and corresponds to a total integrated luminosity of 138 fb$^{-1}$. The observed (expected) upper limit on the inclusive HH production cross section relative to the standard model (SM) prediction is found to be 3.5 (2.5). Assuming all other Higgs boson couplings are equal to their SM values, the Higgs boson trilinear self-coupling modifier $κ_λ=λ_3/λ_{3}^\text{SM}$ is constrained in the range $-$1.35 $\leq$$κ_λ$$\leq$ 6.37 at 95% confidence level. Similarly, for the coupling modifier $κ_{2\mathrm{V}}$, which governs the interaction between two vector bosons and two Higgs bosons, we have excluded $κ_{2\mathrm{V}}$ = 0 at more than 5 standard deviations for all values of $κ_λ$. At 95% confidence level assuming other couplings are equal to their SM values, $κ_{2\mathrm{V}}$ is constrained in the range 0.64 $\leq$ $κ_{2\mathrm{V}}$ $\leq$ 1.40. This work also studies HH production in several new physics scenarios, using the Higgs effective field theory (HEFT) framework. The HEFT framework is further exploited to study various ultraviolet complete models with an extended Higgs sector and set constraints on specific parameters. An extrapolation of the results to the integrated luminosity expected after the high-luminosity upgrade of the LHC is reported as well.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/01/2026
• Auteurs : Cécile VittoriPierre CarbonelIlaria MazziniFerréol SalomonJean-Philippe GoiranSimona PannuziJorge CocquytCamille GonçalvesCarlo RosaL. Schmitt
• Organismes : ARCHEORIENT - Environnements et sociétés de l'Orient ancien Environnements et Paléoenvironnements OCéaniques Istituto di Geologia Ambientale e Geoingegneria Centre National de la Recherche Scientifique Laboratoire Image, Ville, Environnement ARCHEORIENT - Environnements et sociétés de l'Orient ancien Istituto Superiore per la Conservazione ed il Restauro ARCHEORIENT - Environnements et sociétés de l'Orient ancien ARCHEORIENT - Environnements et sociétés de l'Orient ancien Instituto Italiano di Paleontologia Umana Laboratoire Image, Ville, Environnement
• Publié dans Geoarchaeology: An International Journal le 25/10/2020

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Résumé : This study examines long‐term salinity changes in the Ostia Lagoon between the 4th century cal BC and the 6th century cal AD , with emphasis on their implications for ancient salt production. Although Ostia's foundation is closely linked to the control of salt resources in the Tiber Delta, direct archaeological evidence of Roman‐period saltworks is scarce. To address this gap, this study combines micropalaeontological analysis of ostracod assemblages with a morphometric study of sieve pore features in Cyprideis torosa (Jones, 1850). This approach enables reconstruction of short‐term palaeosalinity dynamics. Core LOA–1 documents a transition from peatland to euryhaline lagoon between the 8th–6th and the 4th–3rd centuries cal BC , followed by repeated high‐salinity episodes. A notable peak coincides with the establishment of the Roman Castrum, suggesting favourable conditions for salt concentration. After the mid‐4th century cal BC , salinity peaks decreased, possibly reducing the lagoon's potential for saltworks and fostering greater reliance on the Maccarese saltworks. In the northern lagoon sector, hyperhaline conditions during the Roman period remain uncertain because of chronological gaps and the lack of sieve pore analysis. Overall, the results demonstrate both the potential and limitations of ostracod analysis as a palaeosalinity proxy and refine understanding of salt exploitation in the Tiber Delta. This study provides valuable insights into the long‐term socio‐environmental dynamics of the Mediterranean coastal wetlands, contributing to the advancement of geoarchaeological research on ancient salt production through salterns and its influence on human settlement patterns and economic practices.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/01/2026
• Auteurs : Antoine CazellesQuentin DenostBenjamin FernandezMichel RivoireHélène MeillatPhilippe RouanetMehdi KarouiAdeline GermainLeon MaggioriAlain ValverdeNicolas PeruEddy CotteEtienne BuscailJérémie H. LefevreBertrand TrillingJean Luc FaucheronPierre Yves SageLaura Beyer-BerjotStephane BenoistArnaud AlvèsCharles SabbaghJean‐jacques TuechJulien CogetF. MarchalGuillaume MeuretteDiane MègeDahbia DjelilSimone ManfredelliAurélien VenaraMehdi OuaissiGilles Manceau
• Organismes : Centre de Recherche des Cordeliers Bordeaux Colorectal Institute = Institut Colorectal de Bordeaux Hôpital Haut-Lévêque [CHU Bordeaux] Centre Léon Bérard [Lyon] Institut Paoli-Calmettes Institut régional de Cancérologie de Montpellier Université Paris Cité Service de chirurgie digestive, générale et cancérologique [CHU HEGP] Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy] Hôpital Lariboisière-Fernand-Widal [APHP] Groupe Hospitalier Diaconesses Croix Saint-Simon Hospices Civils de Lyon Institut de Recherche en Santé Digestive Service Chirurgie viscérale et digestive [CHU Toulouse] CHU Saint-Antoine [AP-HP] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Service de Chirurgie Digestive, CHRU Marseille-Nord, Marseille 13015, France. Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Réseau des registres français du cancer CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Chirurgie digestive [CHU Amiens] Simplification des soins chez les patients complexes - UR UPJV 7518 Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Centre de Recherche en Automatique de Nancy
• Publié dans Colorectal Disease le 30/10/2020

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Résumé : Aim Neoadjuvant treatment for rectal cancer has evolved markedly with the growing adoption of total neoadjuvant therapy ( TNT ), organ‐preservation strategies and selective omission of radiotherapy. Recent trials support risk‐based personalization, but its application in real‐world settings remains poorly documented. The aim was to describe current neoadjuvant treatment practices for mid‐low rectal cancer in French expert centres and identify tumour‐ and patient‐related factors influencing decisions. Method This observational study included patients with non‐metastatic rectal adenocarcinoma ≤10 cm from the anal verge, discussed in tumour boards (October 2022 to March 2023) across GRECCAR centres. Tumours were classified as early, intermediate‐risk or locally advanced rectal cancer (LARC). Neoadjuvant treatments were analysed according to tumour extension, location and age. Results Among 463 patients from 27 centres, the most frequent regimen was induction chemotherapy, mainly FOLFIRINOX, followed by long‐course chemoradiotherapy (CRT) (65%). This approach was used in 51%, 66% and 71% of patients in the early, intermediate‐risk and LARC groups, respectively ( p = 0.0060). TNT was more frequently administered for low‐ than mid‐rectal cancers, especially in LARC (86% vs. 71%, p = 0.016). In patients >75 years, CRT + consolidation chemotherapy and radiotherapy alone were proportionally more frequent. Among the early rectal cancers, those treated with induction chemotherapy + CRT had more advanced features than those treated with CRT alone (cT3: 80% vs. 43%, cN+: 62% vs. 10%, tumour size: 3.4 vs. 2.3 cm; all p < 0.001). Conclusion TNT with induction chemotherapy is the predominant neoadjuvant approach in French expert centres. Tumour classification, location and patient age significantly influence treatment choices, reflecting a shift towards personalized context‐specific care.

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• Type de publi. : Article dans une revue
• Date de publi. : 09/01/2026
• Auteurs : Alice NordlingerLoéva MorinAlexandra AndrieuxJean Philippe TraniPierre PerrinNathalie EudesAnne BigotAnne DejeanFrédérique Magdinier
• Organismes : Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis Marseille medical genetics - Centre de génétique médicale de Marseille Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis Marseille medical genetics - Centre de génétique médicale de Marseille Marseille medical genetics - Centre de génétique médicale de Marseille Marseille medical genetics - Centre de génétique médicale de Marseille Centre de recherche en Myologie – U974 SU-INSERM Institut de Myologie Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis Marseille medical genetics - Centre de génétique médicale de Marseille
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Facioscapulohumeral muscular dystrophy (FSHD) is a progressive and debilitating muscle disease for which no cure currently exists. In the majority of cases, FSHD is associated with the contraction of the D4Z4 macrosatellite repeat array at the 4q35 locus, leading to the inappropriate activation of DUX4 , normally expressed during early embryogenesis. In FSHD, the genetic contraction is accompanied by hypomethylation of the D4Z4 array. Although a connection between DNA hypomethylation and DUX4 expression has been suggested, the precise mechanisms that regulate DUX4 transcription remain incompletely defined. The post-translational modification by SUMO was shown previously to repress the expression of Dux , the DUX4 homolog, in mouse embryonic stem cells. Based on these findings, we explored here the contribution of SUMOylation in the regulation of DUX4 in human muscle cells. We demonstrate that TAK‑981 (subasumstat), a selective SUMOylation inhibitor, promotes transcriptional reprogramming of the 4q35 locus and induces DUX4 expression. Importantly, this activation occurs independently of changes in DNA methylation or SMCHD1 ATPase activity. Our findings identify SUMOylation inhibition as a novel regulatory process driving DUX4 expression. This work uncovers the importance of SUMOylation in the epigenetic control of the 4q35 locus and DUX4 transcription, providing a potential therapeutic strategy to modulate DUX4 expression in FSHD.

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Fichiers liés : s41598-025-33624-0-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/01/2026
• Auteurs : François ThermeJean-François ViallardManuela RueterThibault ComontStephane ChezeSylvain AudiaMikael EbboMatthieu MahévasLouis TerriouQuitterie ReynaudPierre-Yves JeandelThomas MoulinetDelphine GobertPhilippe GuilpainClément GourguechonAilsa RobbinsMarc RuivardLaurie ChabbertBernard BonnotteBertrand GodeauMaryse Lapeyre-MestreYoann ZadroMarc MichelGuillaume Moulis
• Organismes : Service Médecine interne [CHU Toulouse] Service de médecine interne et maladies infectieuses [Bordeaux] Centre d'investigation clinique de Toulouse IUCT Oncopole Service Médecine interne [CHU Toulouse] Laboratoire d'Hématologie Biologique [CHU Caen] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon] Research on Healthcare Performance Centre d'investigation clinique de Toulouse
• Publié dans American Journal of Hematology le 26/10/2020

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Résumé : ABSTRACT Adult patients with immune thrombocytopenia (ITP) have an increased risk of venous thrombosis as compared to the general population. The management of ITP in the context of anticoagulation is challenging. We conducted an observational study in the prospective, multicenter, national CARMEN‐France registry. Adult patients with newly diagnosed ITP between June 2013 and May 2022 were selected. We assessed the cumulative incidence of venous thrombosis during follow‐up with death as a competing event, described these events, and assessed patient outcomes depending on management strategies, with a focus on thromboses that occurred during treatment with thrombopoietin receptor agonists (TPO‐RA). Among the 1303 patients selected for this study, 53 experienced venous thrombosis. The cumulative incidence of venous thrombosis was 2.6% (95% CI: 1.8–3.7) at 1 year and 8.6% (95% CI: 5.8–12.0) at 5 years. In patients exposed to TPO‐RA, the cumulative incidence was 9.3% (95% CI: 6.2–13.2) and 13.4% (95% CI: 8.6–19.2) at 1 and 5 years of exposure, respectively. Patients who experienced thrombosis were older, had more frequently a history of venous thrombosis and secondary ITP, a more severe ITP, and were more frequently treated with TPO‐RAs. Twenty (37.7%) of the 53 events were atypical, including five cerebral venous thromboses. Four patients died, and seven experienced major bleeding. The analysis of different managements of ITP after the thrombotic event suggested that the safest strategy was to promptly control ITP to enable early anticoagulation, including using TPO‐RAs. Long‐term anticoagulation therapy should be considered in patients treated with TPO‐RAs and persistent risk factors for thrombosis.

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