Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Auriane BidautErwan FlécherNicolas NesselerKarl BounaderAndré VincentelliMouhammed MoussaClément DelmasJean PorterieKarine NubretMathieu PernotMichel KindoClément SchneiderPhilippe GaudardPhilippe RouvièreMagali MichelThomas SénageAude BoignardOlivier ChavanonConstance VerdonkMarylou ParaBaptiste MailleVlad GariboldiMatteo PozziElisabeth Hugon-ValletPierre-Yves LitzlerFrédéric AnselmeKatrien BlanchartGerard BabatasiMarie BielefeldSandrine GrosjeanCostin RaduDavid HamonThierry BourguignonThibaud GenetRomain EschalierNicolas D’ostrevyHélène NougueAnne Cécile MartinFabrice VanhuyseHugues BlangyChristophe LeclercqRaphaël P MartinsVincent Galand
• Organismes : Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
• Publié dans Critical Care Medicine le 31/10/2020

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Résumé : Objectives: Temporary circulatory support (TCS) as a bridge-to-left ventricular assist device (BTL) in cardiogenic shock patients has been increasing, but limited data exists on this BTL strategy. We aimed at analyzing the outcome of BTL patients in a population of cardiogenic shock patients compared with those without TCS at the time of the left ventricular assist device (LVAD) surgery and identify predictors of postoperative mortality in this specific population.Design: A multicenter retrospective observational study conducted in 19 centers from 2006 to 2016.Setting: Nineteen French centers.Patients: A total of 329 cardiogenic shock patients at the time of LVAD implantation were analyzed. Patients were divided in three groups: those under TCS at the time of LVAD implantation (n = 173), those with TCS removal before LVAD surgery (n = 24), and those who did not undergo a bridging strategy (n = 152). Primary endpoint was 30-day mortality.Interventions: None.Measurements and main results: Among the BTL group, 68 (39.3%), 18 (10.4%), and 15 (8.7%) patients were under venoarterial extracorporeal membrane oxygenation, Impella, and IABP support alone, and 72 patients (20.6%) were under multiple TCS support. BTL patients presented similar 30 days survival compared with the TCS removal and non-BTL groups. However, BTL group had a significantly longer ICU duration stay, with two-fold duration of mechanical ventilation time, but the three groups experienced similar postoperative complications. Multivariate analysis identified three independent predictors of mortality in the BTL group: combined surgery with LVAD, body mass index (BMI), and heart failure (HF) duration. BTL strategy was not an independent predictor of mortality in cardiogenic shock patients who underwent LVAD.Conclusions: BTL strategy is not associated with a lower survival among cardiogenic shock patients with LVAD implantation. Predictors of mortality are combined surgery with LVAD, higher BMI, and HF duration.

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Fichiers liés : 2021Bidaut et al., Outcome.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : David FitzmauriceAgnieszka KotalczykChristine TeutschHans-Christoph DienerSergio DubnerJonathan HalperinChang-Sheng MaKenneth RothmanSabrina MarlerVenkatesh Kumar GurusamyMenno HuismanDzifa Wosornu AbbanEmad AzizMarica Bracic KalanNasser AbdulLuciano Marcelo BackesDrew BradmanAtilio Marcelo AbudE. BadingsDonald BrautigamFran AdamsErmentina BagniNicolas BretonSrinivas AddalaSeth BakerP. BrouwersPedro AdragãoRichard BalaKevin BrowneWalter AgenoAntonio BaldiJordi Bruguera CortadaRajesh AggarwalShigenobu BandoA. BruniSergio AgostiSubhash BanerjeeClaude BrunschwigPiergiuseppe AgostoniAlan BankHervé BuathierFrancisco AguilarGonzalo Barón EsquiviasAurélie BuhlJulio Aguilar LinaresCraig BarrJohn BullingaLuis AguinagaMaria BartlettJose Walter CabreraJameel AhmedVanja Basic KesAlberto CaccavoAllessandro AielloGiovanni BaulaShanglang CaiPaul AinsworthSteffen BehrensSarah CaineJorge Roberto AiubAlan BellLeonardo CalòRaed Al-DallowRaffaella BenedettiValeria CalviLisa AldersonJuan Benezet MazuecosMauricio Camarillo SánchezJorge Antonio Aldrete VelascoBouziane BenhalimaRui CandeiasDimitrios AlexopoulosJutta Bergler-KleinVincenzo CapuanoFernando Alfonso ManterolaJean-Baptiste BerneauAlessandro CapucciPareed AliyarRichard BernsteinRonald CaputoDavid AlonsoPercy BerrospiTatiana Cárdenas RizoFernando Augusto Alves da CostaSergio BertiFrancisco CardonaJosé AmadoAndrea BerzFrancisco Carlos da Costa DarrieuxWalid AmaraElizabeth BestYan Carlos Duarte VeraMathieu AmelotPaulo BettencourtAntonio CaroleiNima AmjadiRobert BetzuSusana CarreñoFabrizio AmmiratiRavi BhagwatPaula CarvalhoMarianna AndradeLuna BhattaSusanna CaryNabil AndrawisFrancesco BiscioneGavino CasuGiorgio AnnoniGiovanni BisignaniClaudio CavalliniGerardo AnsaloneToby BlackGuillaume CaylaM. Kevin ArianiMichael BlochAldo CelentanoJuan Carlos AriasStephen BloomTae-Joon ChaSébastien ArmeroEdwin BlumbergKwang Soo ChaChander AroraMario BoJei Keon ChaeMuhammad Shakil AslamEllen BøhmerKathrine ChalamidasM. AsselmanAndreas BollmannKrishnan ChallappaPhilippe AudouinMaria Grazia BongiorniSunil Prakash ChandCharles AugenbraunGiuseppe BorianiHarinath ChandrashekarS. AydinD. BoswijkLudovic ChartierJochen BottKausik ChatterjeeIvaneta AyryanovaEdo BottacchiCarlos Antero Chavez AyalaAamir CheemaGershan DavisRudolph EvonichAmjad CheemaJean-Marc DavyOksana EvseevaLin ChenMark DayerAndrey EzhovShih-Ann ChenMarzia de BiasioRaed FahmyJyh Hong ChenSilvana de BonisQuan FangFu-Tien ChiangRaffaele de CaterinaRamin FarsadFrancesco ChiarellaTeresiano de FranceschiLaurent FauchierLin Chih-ChanJ. de GrootStefano FavaleYong Keun ChoJosé de HortaMaxime FayardJong-Il ChoiAxel de La BriolleJose Luis FedeleDong Ju ChoiGilberto de La Pena TopeteFrancesco FedeleGuy ChouinardAngelo Amato Vicenzo de PaolaOlga FedorishinaDanny Hoi-Fan ChowWeimar de SouzaSteven FeraDimitrios ChrysosA. de VeerLuis Gustavo Gomes FerreiraGalina ChumakovaLuc de WolfJorge FerreiraEduardo Julián José Roberto Chuquiu ValenzuelaEric DecoulxClaudio FerriNicoleta Cindea NicaSasalu DeepakAnna FerrierDavid CislowskiPascal DefayeHugo FerroAnthony ClayFreddy Del-Carpio MunozAlexandra FinsenPiers CliffordDiana Delic BrkljacicBrian FirstAndrew CohenN. Joseph DeumiteStuart FischerMichael CohenSilvia Di LeggeCatarina FonsecaSerge CohenIgor DiembergerLuísa Fonseca AlmeidaFurio ColivicchiDenise DietzSteven FormanRonan CollinsPedro DionísioBrad FrandsenPaolo ColonnaQiang DongWilliam FrenchSteve ComptonFabio Rossi dos SantosKeith FriedmanDerek ConnollyElena DotchevaAthena FrieseAlberto ContiRami DoukkyAna Gabriela FruntelataGabriel Contreras BuenostroAnthony D’souzaShigeru FujiiGregg CoodleySimon DubreyStefano FumagalliMartin CooperXavier DucrocqMarta FundamenskiJulian CoronelDmitry DupljakovYutaka FurukawaGiovanni CorsoMauricio DuqueMatthias GabelmannJuan Cosín SalesDipankar DuttaNashwa GabraYves CottinNathalie DuvillaNiels GadsbøllJohn CovaleskyA. DuygunMichel GalinierAurel CracanRainer DziewasAnders GammelgaardFilippo CreaCharles EatonPriya GaneshkumarPeter CreanWilliam EavesChristopher GansJames CrenshawL. Ebels-TuinbeekAntonio Garcia QuintanaTina CullenClifford EhrlichOlivier GartenlaubHarald DariusSabine Eichinger-HasenauerAchille GaspardonePatrick DarySteven EisenbergConrad GenzOlivier DascotteAdnan El JabaliFrédéric GeorgerIra DauberMahfouz El ShahawyJean-Louis GeorgesVicente DavalosMauro Esteves HernandesSteven GeorgesonRuth DaviesAna Etxeberria IzalEvaldas GiedrimasMariusz GierbaTetsuya HarunaNabil JarmukliIgnacio Gil OrtegaEmil HayekRobert JeanfreauEve GillespieJeff HealeyRonald JenkinsAlberto GinigerSteven HearneCarlos Jerjes SánchezMichael GiudiciMichael HeffernanJavier JimenezAlexandros GkotsisGeir HeggelundRobert JobeTaya GlotzerJ. HeijmeriksTomas Joen-JakobsenJoachim GmehlingMaarten HemelsNicholas JonesJacek GniotI. HendriksJose Carlos Moura JorgePeter GoethalsSam HeneinBernard JouveSeth GoldbargSung-Ho HerByung Chun JungRonald GoldbergPaul HermanyKyung Tae JungBritta GoldmannJorge Eduardo Hernández del RíoWerner JungSergey GolitsynYorihiko HigashinoMikhail KachkovskiySilvia GómezMichael HillKrystallenia KafkalaJuan Gomez MesaTetsuo HisadomeLarisa KalininaVicente Bertomeu GonzalezEiji HishidaBernd KallmünzerJesus Antonio Gonzalez HermosilloEtienne HofferFarzan KamaliVíctor Manuel González LópezMatthew HoghtonTakehiro KamoHervé GorkaKui HongPriit KampusCharles GornickSuk Keun HongHisham KashouDiana GorogStevie HorbachAndreas KastrupVenkat GottipatyMasataka HoriuchiApostolos KatsivasPascal GoubeYinglong HouElizabeth KaufmanIoannis GoudevenosJeff HsingKazuya KawaiBrett GrahamChi-Hung HuangKenji KawajiriG. Stephen GreerDavid HuckinsJohn KazmierskiUwe GremmlerKathy HughesP. KeelingPaul GrenaA. HuizingaJosé Francisco Kerr SaraivaMartin GrondE. HulsmanGalina KetovaEdoardo GrondaKuo-Chun HungAjit Singh KhairaGerian GrönefeldGyo-Seung HwangAleksey KhripunXiang GuMargaret IkpohDoo-Il KimIvett Guadalupe Torres TorresDavide ImbertiYoung Hoon KimGabriele GuardigliHüseyin InceNam Ho KimCarolina GuevaraCiro IndolfiDae Kyeong KimAlexandre GuignierShujiro InoueJeong Su KimMichele GuliziaDidier IrlesJune Soo KimMichael GumbleyHarukazu IsekiKi Seok KimAlbrecht GüntherC. Noah IsraelJin Bae KimAndrew HaBruce IteldElena KinovaGeorgios HahalisVenkat IyerAlexander KleinJoseph HakasEwart Jackson-VoyzeyJames KmetzoChristian HallNaseem JaffraniG. Larsen KnellerBing HanFrank JägerAleksandar KnezevicSeongwook HanMartin JamesSu Mei Angela KohJoe HargroveSung-Won JangShunichi KoideDavid HargrovesNicolas JaramilloAnastasios KolliasJ. KooistraWeihua LiJohn McclureJay KoonsXiaoming LiTerry MccormackMartin KoschutnikChristhoh LichyWilliam McgarityWilliam KostisIra LieberHugh McintyreDragan KovacicRamon Horacio Limon RodriguezBrent MclaurinJacek KowalczykHailong LinFeliz AlvaroMedina PalominoNatalya KoziolovaFrancesco MelandriPeter P. KraftFeng LiuHiroshi MenoJohannes KragtenHengliang LiuDhananjai MenziesMori KrantzGuillermo Llamas EsperonMarco MercaderLars KrauseNassip Llerena NavarroChristian MeyerB. KrenningEric LoBeat MeyerF. KrikkeSergiy LokshynJacek MiarkaZ. KromhoutAmador LópezFrank MibachWaldemar KrysiakJosé Luís López-SendónDominik MichalskiPriya KumarAdalberto Menezes Lorga FilhoPatrik MichelThomas KümlerRichard LorraineRami Mihail ChreihMalte KunissCarlos Alberto LuengasAlberto LuengasGhiath MikdadiJen-Yuan KuoRobert LukeMilan MikusAchim KüppersMing LuoDavor MilicicKarla KurrelmeyerSteven LupovitchConstantin MilitaruChoong Hwan KwakPhilippe LyrerSedi MinaieBénédicte LaboulleChangsheng MaBogdan MinescuArthur LabovitzGenshan MaIveta MintaleWen ter LaiIrene MadariagaTristan MiraultAndy LamKoji MaenoMichael MirroYat Yin LamDominique MagninDinesh MistryFernando Lanas ZanettiGustavo MaidNicoleta Violeta MiuCharles LandauSumeet MainigiNaomasa MiyamotoGiancarlo LandiniKonstantinos MakaritsisTiziano MoccettiEstêvão Lanna FigueiredoRohit MalhotraAkber MohammedTorben LarsenRickey ManningAzlisham Mohd NorKarine LavandierAthanasios ManolisMichael MollerusJessica LeblancHelard Andres Manrique HurtadoGiulio MolonMoon Hyoung LeeIoannis MantasSergio MondilloChang-Hoon LeeFernando Manzur JattinPatrícia MonizJohn LehmanVicky MaquedaLluis MontAna LeitãoNiccolo MarchionniVicente MontagudNicolas LelloucheFrancisco Marin OrtunoOscar MontañaMalgorzata LelonekAntonio Martín SantanaCristina MontiRadoslaw LenarczykJorge MartinezLuciano MorettiT. LenderinkPetra MaskovaKiyoo MoriSalvador León GonzálezNorberto Matadamas HernandezAndrew MoriartyPeter Leong-SitKatsuhiro MatsudaJacek MorkaMatthias LeschkeTillmann MaurerLuigi MoschiniNicolas LeyCiro MauroNikitas MoschosZhanquan LiErik MayAndreas MüggeXiaodong LiNolan MayerThomas MulhearnCarmen MuresanEena Padayattil JoseDalton Bertolim PrécomaMichela MuriagoFrancisco Gerardo Padilla PadillaAlessandro PrelleWlodzimierz MusialVictoria Padilla RiosJohn ProdafikasCarl MusserGiuseppe PajesKonstantin ProtassovFrancesco MusumeciA. Shekhar PandeyMaurice PyeThuraia NagehGaetano PaparellaZhaohui QiuHidemitsu NakagawaF. ParisJean-Michel QuedillacYuichiro NakamuraHyung Wook ParkDimitar RaevToru NakayamaJong Sung ParkCarlos Antonio Raffo GradoGi-Byoung NamFragkiskos ParthenakisSidiqullah RahimiMichele NannaEnrico PassamontiArturo RaisaroIndira NatarajanRajesh PatelBhola RamaHemal NayakJaydutt PatelRicardo RamosStefan NaydenovMehool PatelMaria RanieriJurica NazlićJanice PatrickNuno RaposoAlexandru Cristian NechitaRicardo Pavón JimenezEric RashbaLibor NechvatalAnalía PazUrsula Rauch-KroehnertSandra Adela NegronVittorio PengoRamakota ReddyJames NeimanWilliam PentzGiulia RendaFernando Carvalho NeuenschwanderBeatriz PérezShabbir RezaDavid NevesAlma Minerva Pérez RíosLuigi RiaAnna NeykovaAlejandro Pérez-CabezasDimitrios RichterRicardo Nicolás MiguelRichard PerlmanHans RickliGeorge NijmehViktor PersicWerner RiekerAlexey NizovFrancesco PerticoneTomas Ripolil VeraRodrigo Noronha CamposTerri PetersLuiz Eduardo RittJanko NossanSanjiv PetkarDouglas RobertsTatiana NovikovaLuis Felipe PezoIgnacio Rodriguez BrionesEwa Nowalany-KozielskaChristian PflückeAldo Edwin Rodriguez EscuderoEmmanuel NsahDavid PhamCarlos Rodríguez PascualJuan Carlos Nunez FragosoRoland PhillipsMark RomanSvetlana NurgalievaStephen PhlaumFrancesco RomeoDieter NuyensDenis PietersE. RonnerOle NyvadJulien PineauJean-Francois RouxManuel Odin de Los Rios IbarraArnold PinterNadezda RozkovaPhilip O’donnellFausto PintoMiroslav RubacekMartin O’donnellR. PistersFrank RubalcavaSeil OhNediljko PivacAndrea RussoYong Seog OhDarko PocanicMatthieu Pierre RutgersDongjin OhCristian PodoleanuKarin RybakGilles O‘haraAlessandro PolitanoSamir SaidKostas OikonomouZdravka PoljakovicTamotsu SakamotoClaudia OlivaresStewart PollockAbraham SalacataRichard OliverJose Polo GarcéaAdrien SalemRafael Olvera RuizHolger PoppertRafael Salguero BodesChristoforos OlympiosMaurizio PorcuMarco SaltzmanAnna Omaszuk-KazberukAntonio Pose ReinoAlessandro SalvioniJoaquín Osca AsensiNeeraj PrasadGregorio Sanchez VallejoMarcelo Sanmartín FernándezAdam SokalTian Ming TuWladmir Faustino SaporitoYannie Soo Oi YanYpe TuiningaKesari SarikondaRodolfo SotolongoMinang TurakhiaTaishi SasaokaOlga Ferreira de SouzaSamir TurkHamdi SatiJon Arne SparbyWayne TurnerIrina SavelievaJindrich SpinarArnljot TveitPierre-Jean ScalaDavid SprigingsRichard TytusPeter SchellingerAlex SpyropoulosC. ValadãoCarlos ScherrDimitrios StakosP. van BergenLisa SchmitzClemens SteinwenderPhilippe van de BorneKarl-Heinz SchmitzGeorgios StergiouB. van den BergBettina SchmitzIan StiellC. van Der ZwaanTeresa SchnabelMarcus StoddardM. van EckSteffen SchnuppAnastas StoikovPeter VanackerPeter SchoenigerWitold StrebDimo VasilevNorbert SchönIoannis StyliadisVasileios VasilikosPeter SchwimmbeckGuohai SuMaxim VasilyevClare SeamarkXi SuSrikar VeerareddyGreg SearlesWanda SudnikMario Vega MiñoKarl-Heinz SeidlKai SuklesAsok VenkataramanBarry SeidmanXiaofei SunPaolo VerdecchiaJaroslaw SekH. SwartFrancesco VersaciLakshmanan SekaranJanko Szavits-NossanErnst Günter VesterCarlo SerratiJens TaggeselleHubert VialNeerav ShahYuichiro TakagiJason VictoryVinay ShahAmrit Pal Singh TakharAlejandro VillamilAnil ShahAngelika TammMarc VincentShujahat ShahKatsumi TanakaAnthony VlastarisVijay Kumar SharmaTanyanan TanawuttiwatJürgen Vom DahlLouise ShawSherman TangKishor VoraKhalid SheikhAylmer TangRobert VranianNaruhito ShimizuGiovanni TarsiPaul WakefieldHideki ShimomuraTiziana TassinariNingfu WangDong-Gu ShinAshis TayalMingsheng WangEun-Seok ShinMuzahir TayebjeeXinhua WangJunya ShiteJ. BergIacopo VivarelliGerolamo SibilioDan TesloianuTian WangFrank SilverSalem TheAlberta WarnerIveta SimeDierk ThomasKouki WatanabeTim SimmersSerge TimsitJeanne WeiNarendra SinghTetsuya TobaruChristian WeimarPeter SiostrzonekAndrzej Tomasik.Stanislav WeinerDidier SmadjaMikhail TorosoffRenate WeinrichDavid SmithEmmanuel TouzeMing-Shien WenMarcelo SnitmanElina TrendafilovaMarcus WiemerDario Sobral FilhoW. Kevin TsaiPreben WiggersHassan SodaHung Fat TseAndreas WilkeCarl SofleyHiroshi TsutsuiDavid WilliamsMarcus WilliamsPing Yen Bryan YanPing ZhangBernhard WitzenbichlerTianlun YangJun ZhangBrian WongJing YaoShui Ping ZhaoKa Sing Lawrence WongKuo-Ho YehYujie ZhaoBeata Wozakowska-KaplonWei Hsian YinZhichen ZhaoShulin WuYoto YotovYang ZhengRichard WuRalf ZahnJing ZhouSilke WunderlichStuart ZarichSergio ZimmermannNell WyattSergei ZeninAndrea ZiniJohn WylieElisabeth Louise ZeuthenSteven ZizzoTaslima AnwarHuanyi ZhangWenxia ZongXiangdong XuDonghui ZhangLsteven ZukermanHiroki YamanoueXingwei ZhangTakeshi Yamashita
• Organismes : Universität Duisburg-Essen = University of Duisburg-Essen [Essen] Icahn School of Medicine at Mount Sinai [New York] Cardiology Division Leiden University Medical Center [Leiden] Monash University [Clayton] Éducation Éthique Santé
• Publié dans Clinical Research in Cardiology le 30/10/2020

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Résumé : In this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Gérard ReachLaurent BenarbiaPierre-Yves BenhamouBrigitte DelemerSéverine DuboisDidier GouetBruno GuerciNathalie JeandidierKarim LachgarGilles Le PapeRémy LeroyJean-Hugues MasgnauxPhilippe RacletYves ReznikJean-Pierre RivelinePauline SchaepelynckAnne VambergueBruno Vergès
• Organismes : Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283
• Publié dans Patient Preference and Adherence le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Olivier RampinAudrey Saint Albin DeliotChristian OualiJasmine BurguetElisa GryGaëlle Champeil-PotokarNathalie JérômeOlga DavidenkoNicolas DarcelVincent BombailPhilippe AndreyIsabelle Denis
• Organismes : Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Institut Jean-Pierre Bourgin - Sciences du végétal Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Institut Jean-Pierre Bourgin - Sciences du végétal Physiologie de la Nutrition et du Comportement Alimentaire
• Publié dans Biomedicines le 28/10/2020

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Résumé : Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals. For eliciting feeding behaviour, food odour coding has to gain signification through enrichment with additional labelling in the brain. Since the ventral striatum, at the crossroads of olfactory and reward pathways, receives a rich dopaminergic innervation, we hypothesized that dopamine plays a role in food odour information processing in the ventral striatum. Using single neurones recordings in anesthetised rats, we show that some ventral striatum neurones respond to food odour. This neuronal network displays a variety of responses (excitation, inhibition, rhythmic activity in phase with respiration). The localization of recorded neurones in a 3-dimensional brain model suggests the spatial segregation of this food-odour responsive population. Using local field potentials recordings, we found that the neural population response to food odour was characterized by an increase of power in the beta-band frequency. This response was modulated by dopamine, as evidenced by its depression following administration of the dopaminergic D1 and D2 antagonists SCH23390 and raclopride. Our results suggest that dopamine improves food odour processing in the ventral striatum.

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Fichiers liés : Rampin_2022_biomedicines.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Basma Akrout BrizardPhilippe CourtetIsabelle JaussentJorge Lopez-CastromanMarion LeboyerJean Pierre KahnCarolina Baeza-Velasco
• Organismes : Laboratoire de Psychopathologie et Processus de Santé Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Institut des Neurosciences de Montpellier Centre Hospitalier Universitaire de Nîmes Institut de Génomique Fonctionnelle IMRB - "Neuropsychiatrie translationnelle" [Créteil] CHU Henri Mondor [Créteil] Université de Lorraine Fondation Santé des Etudiants de France Laboratoire de Psychopathologie et Processus de Santé Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle
• Publié dans Journal of Clinical Psychiatry le 27/10/2020

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Résumé : Background: Suicidal behaviors are known to be increased in people with epilepsy compared to the general population. However, few studies have explored the frequency of epilepsy in a large sample of suicide attempters, and scarce data exist about differences and similarities between epileptic attempters (EA) and nonepileptic attempters (NEA). The aim of this study was to explore the frequency of epilepsy as well as psychopathological and somatic factors among suicide attempters.Methods: In this multicenter cross-sectional study, 1,229 adults hospitalized for attempted suicide were included during the period between July 2001 and December 2015. They were assessed with the Mini-International Neuropsychiatric Interview for DSM-IV Axis I mental disorders. Data concerning sociodemographic and somatic diseases, including epilepsy, were collected.Results: Sixty-five patients (5.3%) had epilepsy. EA had significantly fewer mean ± SD years of education compared with NEA (11.2 ± 3.2 vs 12.1 ± 2.9; P = .011) as well as increased rates of head trauma (29.2% for EA vs 16.2% for NEA; P = .007), antiepileptic use (35.4% for EA vs 23.8% for NEA; P = .036), and lifetime substance abuse and/or dependance (49.2% for EA vs 36.1% for NEA; P = .034). Multivariate analyses showed that years of education, head trauma, and panic disorder with agoraphobia predicted belonging to the EA group.Conclusions: These results suggest that epilepsy is overrepresented among suicide attempters. Few psychopathological differences as well as differences in somatic comorbidities except head trauma were observed between EA and NEA in this sample. These results contribute to draw a clinical profile of people with epilepsy in the population of suicide attempters.

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• Type de publi. : Rapport
• Date de publi. : 01/05/2022
• Auteurs : Sylvain BilletNathalie BonvallotDany ChevalierClaude EmondJérôme ThireauMichiels FabriceVincent RaymondBaril MarcBinet StéphaneBisson MichèleChevalier AnneEl-Ghissassi FatihaEl-Yamani MouniaFitzgerald RexGarnier RobertHoet PerrineIwatsubo YurikoKairo CécileLakhal LailaLirussi FrédéricMaitre AnnePilliere FlorencePlatel AnneSchroeder HenriSorg OlivierViau ClaudeNadif RachelParis ChristopheAchard SophieAschan-Leygonie ChristinaBemer DenisBex ValérieCaillaud DenisDewitte Jean-DominiqueDurif MarcFrealle EmilieGlorennec PhilippeGoupil GhislaineGuillemot MarianneJacquemin BénédicteJoubert OlivierLuce DanièleMandin CorinneMercier FabienMonteil ChristelleOppliger AnnePernot PierreRaherison ChantalBelzunces LucBotineau CélineClinard FrançoisHogeveen KevinMultigner LucNikolova-Pavageau NadiaOury BenoîtWendremaire MaevaLaborde-Castérot HervéAlliot FabriceAndré MichelPatrick BrochardDelva FleurGaie-Levrel FrançoisHulin MarionLarbre JulietteLe Bot BarbaraLepeule JohannaPham Thi NhanThibaudier Jean-MarcEmmanuelle DurandClémence FourneauKeirsbulck Marion.
• Organismes : Université du Littoral Côte d'Opale Unité de Chimie Environnementale et Interactions sur le Vivant Département Santé Environnement Travail et Génie Sanitaire École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail Université de Lille Université de Montréal Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Association des Centres Interentreprises pour la Santé au Travail Université de Montréal Institut des Sciences de la Terre d'Orléans - UMR7327 Biogéosystèmes Continentaux - UMR7327 Institut National de l'Environnement Industriel et des Risques Centre international de Recherche sur le Cancer Santé publique France - French National Public Health Agency [Saint-Maurice, France] Centre Suisse de Toxicologie Humaine Appliquée | Swiss Centre for Applied Human Toxicology Centre antipoison et de toxicovigilance (Paris) Université Catholique de Louvain = Catholic University of Louvain Santé publique France - French National Public Health Agency [Saint-Maurice, France] Santé publique France - French National Public Health Agency [Saint-Maurice, France] ToxAlim Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Environnement et Prévention en Santé des Populations Département Études et assistance médicales Impact de l'environnement chimique sur la santé humaine - ULR 4483 Nutrition-Génétique et Exposition aux Risques Environnementaux Université de Genève = University of Geneva Université de Montréal Centre de recherche en épidémiologie et santé des populations Institut National de la Santé et de la Recherche Médicale Université Paris Cité Environnement, Ville, Société Université Lumière - Lyon 2 Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) Ville de Paris Université Clermont Auvergne Service Pneumologie / Allergologie [CHU Clermont-Ferrand] Optimisation des régulations physiologiques Institut National de l'Environnement Industriel et des Risques Centre Hospitalier Régional Universitaire [CHU Lille] Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique Laboratoire Central de la Préfecture de Police Département Métrologie des Polluants Institut de recherche en santé, environnement et travail Institut Jean Lamour Institut National de la Santé et de la Recherche Médicale Centre Scientifique et Technique du Bâtiment Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Laboratoire d'étude et de recherche en environnement et santé Aliments Bioprocédés Toxicologie Environnements Université de Lausanne = University of Lausanne AIRPARIF - Surveillance de la qualité de l'air en Île-de-France Bordeaux population health Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Commissariat à l'énergie atomique et aux énergies alternatives Santé publique France - French National Public Health Agency [Saint-Maurice, France] Laboratoire de Fougères - ANSES Institut de recherche en santé, environnement et travail Institut national de recherche et de sécurité (Paris) Institut national de recherche et de sécurité (Paris) Lipides - Nutrition - Cancer [Dijon - U1231] Université Bourgogne Franche-Comté [COMUE] Centre antipoison et de toxicovigilance (Paris) Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols Département Composants et Systèmes Bordeaux population health Bordeaux population health Laboratoire National de Métrologie et d’Essais Santé publique France - French National Public Health Agency [Saint-Maurice, France] Service parisien de santé environnementale [Paris] Laboratoire d'étude et de recherche en environnement et santé Épidémiologie environnementale appliquée au développement et à la santé respiratoire/Environmental Epidemiology applied to Development and Respiratory Health Direction de l'Evaluation des Risques Direction de l'Evaluation des Risques Direction de l'Evaluation des Risques

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Résumé : La question de l’exposition de l’humain à des mélanges et du risque associé potentiel pour la santé se pose depuis de nombreuses années. Des documents et recommandations institutionnels sont notamment publiés depuis les années 2000 pour la prise en compte des mélanges, principalement dans le cadre d’évaluation des risques sur la santé (US EPA, 2000 ; 2002 ; 2006 ; ILSI, 1999; ATSDR, 2001 ; 2004; Health Council of the Netherlands, 2002; IGHRC, 2008; EFSA, 2008 ; 2009 ; 2013; WHO-IPCS, 2009; Kortenkamp et al., 2009; SCHER, 2011). Dans le domaine des substances chimiques, le nombre de composés enregistrés par le Chemical Abstract Service (CAS) était de 34 millions en 2008 (Stewart and Carter, 2009). En 2018, plus de 17 000 substances individuelles avaient été enregistrées dans le cadre de la réglementation européenne REACh (Registration, Evaluation and Authorisation of Chemicals) (règlement n°1907/2006). Le nombre exact de substances chimiques sur le marché de l’Union européenne n’est pas connu précisément mais l’agence européenne des substances chimiques (ECHA) l’estimait en 2017 à près de 140 000 substances (https://echa.europa.eu/fr/registration-statistics-infograph#). Les contaminations environnementales (air, eau, sols etc.) par les substances chimiques peuvent résulter notamment : (i) des procédés de fabrication conduisant à des émissions potentielles dans l’air, l’eau et/ou les sols ; (ii) de l’utilisation de produits de consommation contenant des substances chimiques dans la vie quotidienne ; (iii) des émissions issues non intentionnellement de la combustion ; (iv) de la persistance dans l’environnement de substances qui peuvent être interdites à présent par la réglementation, etc. La gestion des risques liés aux substances chimiques est encadrée, d’une part par le règlement REACh, et d’autre part, par des réglementations par milieux (eau, air, etc.) et sectorielles (médicaments, cosmétiques, biocides, etc.), d’où découlent des analyses de risques séparées (Evans et al., 2016). Concernant les mélanges de substances chimiques, il existe dans certaines de ces réglementations des référentiels de gestion des risques cumulés proposant une approche progressive par étape. C’est le cas pour l’exposition via l’alimentation (résidus de pesticides et eaux destinées à la consommation humaine) et pour l’étude de l’impact d’installations industrielles sur l’environnement et le voisinage. La question des mélanges, si elle reste complexe, peut donc aujourd’hui être prise en compte dans les démarches d’expertise, compte tenu de l’existence de savoir-faire et de développement de modèles simplifiés faisant relativement consensus. Des recommandations d’organismes institutionnels (United States Environment Protection Agency (US-EPA), Agency for Toxic Substances and Disease Registry (ATSDR), European Food Safety Authority (EFSA), Scientific Committee on Health and Environmental Risks (SCHER)) soulignent l’importance de leur mise en application et formalisent des approches méthodologiques prenant en compte ou non les interactions entre les contaminants.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Pierre-Marie ChevillardMartine BataillerBenoît PiéguAnthony EstienneMarie-Claire BlacheJean-Philippe DuboisDelphine PillonPascal VaudinJoëlle DupontNathalie JustMartine Migaud
• Organismes : Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly]
• Publié dans Histochemistry and Cell Biology le 26/10/2020

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Résumé : Sheep, like most seasonal mammals, exhibit a cyclic adaptive reproductive physiology that allows ewes to give birth to their progeny during the spring when environmental conditions are favorable to their survival. This process relies on the detection of day length (or photoperiod) and is associated with profound changes in cellular plasticity and gene expression in the hypothalamic-pituitary-gonadal axis, mechanisms that are suggested to participate in the seasonal adaptation of neuroendocrine circuits. Recently, pituitary vascular growth has been proposed as a seasonally regulated process in which the vascular endothelial growth factor A (VEGFA), a well-known angiogenic cytokine, is suspected to play a crucial role. However, whether this mechanism is restricted to the pituitary gland or also occurs in the mediobasal hypothalamus (MBH), a crucial contributor to the control of the reproductive function, remains unexplored. Using newly developed image analysis tools, we showed that the arcuate nucleus (ARH) of the MBH exhibits an enhanced vascular density during the long photoperiod or non-breeding season, associated with higher expression of VEGFA. In the median eminence (ME), a structure connecting the MBH to the pituitary gland, higher VEGFA, kinase insert domain receptor (KDR/VEGFR2) and plasmalemma vesicle-associated protein (PLVAP) gene expressions were detected during the long photoperiod. We also found that VEGFA and its receptor, VEGFR2, are expressed by neurons and tanycytes in both the ARH and ME. Altogether, these data show variations in the MBH vasculature according to seasons potentially through a VEGFA-dependent pathway, paving the way for future studies aiming to decipher the role of these changes in the hypothalamic control of seasonal reproduction.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Gérard ReachLaurent BenarbiaPierre-Yves BenhamouBrigitte DelemerSéverine DuboisDidier GouetBruno GuerciNathalie JeandidierKarim LachgarGilles Le PapeRémy LeroyJean-Hugues MasgnauxPhilippe RacletYves ReznikJean-Pierre RivelinePauline SchaepelynckAnne VambergueBruno Vergès
• Organismes : Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée
• Publié dans Patient Preference and Adherence le 27/10/2020

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Résumé : Background: Support programs are provided to people with diabetes to help them manage their disease. However, adherence to and persistence in support programs are often low, making it difficult to demonstrate their effectiveness. Aim: To identify the determinants of patients' perceived interest in diabetes support programs because it may be a powerful determinant of effective participation in such programs. Patients and methods: An online study conducted in April 2021 in metropolitan France on 600 people with diabetes recruited from a consumer panel. A 64-item psychosocial questionnaire including a question asking to evaluate the helpfulness of a support program was used. Univariate, multivariate, and multiple correspondence analyses were performed. Results: The existence of a typology, known as Unsafe/Safe, was discovered, in which patients with type 2 diabetes respond in two distinct ways. Type U (unsafe) patients, who believe that a support program would be helpful, are more likely to be nonadherent to their treatment, have high hemoglobin A1c levels, have at least one diabetic complication, lack information regarding their disease and treatment, rate the burden of their disease and impairment of their quality of life as high, worry about their future, and are pessimistic. Type S (safe) patients have the opposite characteristics. Type U patients can be dichotomized into two broad classes: one in which they lack information regarding disease and treatment and the other in which alterations in the quality of life and burden of the disease predominate. Insulin-treated patients give more importance to the lack of information, whereas noninsulin-treated patients complain primarily about the burden of the disease and impairment of quality of life. Conclusion: This study describes this new U/S typology, proposes a simple method based on a nine-item questionnaire to identify type U patients by calculating a Program Helpfulness Score described herein, and clarifies the nature of the intervention to be provided to them. This novel approach could be applied to other chronic diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Arnaud PagèsNadège CostaMichaël MouniéPhilippe CestacPhilipe Barreto de SoutoYves RollandBruno VellasLaurent MolinierBlandine Juillard-CondatBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre d'Epidémiologie et de Recherche en santé des POPulations Institut universitaire de France Equipe EQUITY (CERPOP) Equipe EQUITY (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe EQUITY (CERPOP) Equipe BIOETHICS (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP)
• Publié dans Drugs and Aging le 01/11/2020

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Résumé : Introduction: Potentially inappropriate medication prescribing (PIP) among older patients is associated with an increased risk of adverse events and hospitalization, and sometimes increased healthcare costs. Objective: The aim of this study was to explore the association between healthcare costs and PIP exposure among older patients. Methods: Analyses were conducted using data from the Multidomain Alzheimer Preventive Trial (MAPT). A computer algorithm was constructed to detect PIP based on various different explicit criteria-based tools, and the results were expressed in number of medication-related potential non-compliances (MRNCs). A prescription was considered potentially inappropriate if there were one or more MRNCs. We performed a cost analysis from the French National Health Insurance perspective, and also performed a multivariate analysis to identify the association between healthcare costs and PIP (number of MRNCs). Results: The computer algorithm analyzed medication prescribing from included patients (N = 1525 aged 75.3 ± 4.4 years; 64% women [n = 978]). PIP was associated with increased total healthcare costs and non-medication healthcare costs after adjusting for potential confounders. We also noted that healthcare costs tended to increase with the number of MRNCs. The mean additional healthcare costs were €517, €921, and €1669 per patient and year for patients with one or two MRNCs, three or four MRNCs, and five or more MRNCs, respectively, in comparison with patients with appropriate medication prescriptions. Conclusion: These observations led us to conclude that interventions focused on reducing PIP could result in savings. Trial registration: ClinicalTrials.gov: NCT00672685.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2022
• Auteurs : Christina BergqvistLaura FertittaKhaled EzzedineArnaud JannicOuidad ZehouSalah FerkalPatrick CombemaleSébastien BarbarotJuliette Mazereeuw-HautierÉmilie SbidianPierre WolkensteinHenri AdamskiClarisse Baumann-MorelChristine BellannéEric BiethPascal BousquetChristian BrandtXavier BalgueriePierre CastelnauYves ChaixJacqueline Chevrant-BretonEvelyne ColletJean‐françois CunyPascal ChastagnerMarie‐lorraine ChandeclercEmmanuel CheuretPascal CintasHélène DollfusChristian DerancourtValérie Drouin-GarraudMichel d'IncanHélène de LeersnyderOlivier DereureDiane DoumarNicolas FabreChristine FrancannetLaurence FaivreFlorence FellmannNathalie Feugier-FavierDominique GaillardAlice GoldenbergLucie Guyant-MarechalBernard GuillotJean‐sebastien GuillamoSmail Hadj‐rabiaDominique Hamel-TeillacIsabelle KemlinJean‐philippe LacourVeronique LaithierNathalie LesavreStanislas LyonnetKim MaincentSophie MaradeixLaurent MachetEva MansatNicolas MeyerMonique MozelleJean Christophe Moreno Celine MoretEric PuzenatBéatrice ParfaitStéphane PinsonEric PasmantDiana RodriguezJean‐françois StalderElisabeth SchweitzerClaire ThalamasChristel Thauvin-RobinetDominique VidaudMichel VidaudAlain VerloesJacques Zeller
• Organismes : CHU Henri Mondor [Créteil] Hôpital Necker - Enfants Malades [AP-HP] Epidemiology in Dermatology and Evaluation in Therapeutics CHU Henri Mondor [Créteil] CHU Henri Mondor [Créteil] Epidemiology in Dermatology and Evaluation in Therapeutics CHU Henri Mondor [Créteil] Centre Léon Bérard [Lyon] Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Universitaire de Toulouse Epidemiology in Dermatology and Evaluation in Therapeutics Centre d'Investigation Clinique Henri Mondor Epidemiology in Dermatology and Evaluation in Therapeutics Institut Mondor de Recherche Biomédicale Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire de Toulouse Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire Laboratoire de pharmacologie et toxicologie neurocardiovasculaire CHU Rouen Imaging, Brain & Neuropsychiatry Toulouse NeuroImaging Center Centre Hospitalier Universitaire de Toulouse Service de Dermatologie [Rennes] = Dermatology [Rennes] Centre d'Investigation Clinique [Rennes] Service de Dermatologie (CHU de Dijon) Centre de Recherche en Automatique de Nancy Service Neurologie Pédiatrique [CHU Toulouse] Département Neurologie [CHU Toulouse] Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier de Gap Service de génétique [Rouen] Imagerie Moléculaire et Stratégies Théranostiques CHU Gabriel Montpied [Clermont-Ferrand] Pathogenesis and Control of Chronic and Emerging Infections Pharmacochimie et Biologie pour le Développement Service Génétique Médicale [CHU Clermont-Ferrand] Lipides - Nutrition - Cancer [Dijon - U1231] FHU TRANSLAD (CHU de Dijon) Université de Lausanne = University of Lausanne Imaging, Brain & Neuropsychiatry
• Publié dans Journal of the European Academy of Dermatology and Venereology le 27/10/2020

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Résumé : Background: Neurofibromatosis 1 (NF1) is one of the most common inherited disorders characterized by mutations in the tumour suppressor gene NF1. Its clinical manifestations are highly variable and unpredictable. A specific NF1 mutation does not predict the severity or complications of the disease. Objective: The objective of this study was to build an empirical classification scheme without any a priori hypotheses to identify the underlying NF1 subtypes that best explain the observed heterogeneity. Methods: We performed latent class analysis (LCA) of 1351 consecutive NF1 patients aged >17 years seen between 2002 and 2014. Data and phenotypic features were collected prospectively on a standardized form. Results: The median age was 36.8 (17-81) years. A three-class model showed the best fit: 706 (52%) belonged to the LC1 'Cutaneous neurofibromas' class having preferentially cutaneous neurofibromas (99%), plexiform neurofibromas (63%) and blue-red macules (29%); 593 (44%) belonged to the LC2 'Subcutaneous neurofibromas' class characterized by the presence of at least 10 subcutaneous neurofibromas (21%) and a familial form (77%) and 52 (4%) belonged to the LC3 'Dysmorphic phenotype' class characterized by dysmorphic features (78%) and learning difficulties (87%). Patients in LC1 had a higher likelihood of developing scoliosis (RR = 1.7, 95% confidence interval (CI) [1.2-2.4]). Patients in LC2 were more likely to be men (RR = 1.4, 95% CI [1.1-1.7]). Patients in LC3 were at higher risk of having an optic pathway glioma (RR = 4.8, 95% CI [1.9-11.8]) and epilepsy (RR = 4.5, 95% CI [1.8-11.6]). Conclusion: Our findings invite the performance of a larger cohort study to test whether the various latent classes reflect different underlying genetic modifiers of these phenotypic traits.

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Fichiers liés : Acad Dermatol Venereol - 2022 - Bergqvist - Identification of three clinical neurofibromatosis 1 subtypes Latent class.pdf

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