Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2022
• Auteurs : Florence JolyMichel FabbroPhilippe FollanaJustine LequesneJacques MedioniAnne LesoinJean-Sébastien FrenelSophie Abadie-LacourtoisieAnne FloquetLaurence GladieffBenoît YouCéline GavoilleElsa KalbacherMélanie BriandPierre-Emmanuel BrachetFlorence GiffardLouis-Bastien WeiswaldPierre-Alexandre JustCécile Blanc-FournierAlexandra LeconteBénédicte ClarisseAlexandra LearyLaurent Poulain
• Organismes : Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Service de recherche clinique [Centre François Baclesse] Institut régional de Cancérologie de Montpellier Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Hôpital Européen Georges Pompidou [APHP] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Bergonié [Bordeaux] Oncopole Claudius Regaud Hospices Civils de Lyon Ciblage thérapeutique en Oncologie Service d'oncologie médicale [ICL Alexis Vautrin] Service d'Oncologie Médicale [CHRU Besançon] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Université Paris-Saclay Assistance publique - Hôpitaux de Paris (AP-HP) Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Département de médecine oncologique [Gustave Roussy] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Comprehensive Cancer Centre François Baclesse
• Publié dans Gynecologic Oncology le 25/10/2020

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Résumé : Background: There are limited treatment options for ovarian cancer patients with early relapse after platinum chemotherapy. In preclinical studies, we previously demonstrated the promising activity of ABT-737, a Bcl-2/Bcl-xL anti-apoptotic protein inhibitor, in chemo-resistant ovarian cancer cells and tumors, suggesting its potential activity in platinum-resistant patients. Methods: We conducted a prospective multicenter single-arm phase II study to assess the efficacy of Navitoclax (orally available ABT-737 analogue) monotherapy in 46 heavily pretreated (2-12 lines, median = 4) patients with high-grade serous platinum-resistant ovarian tumors. Navitoclax was administered at the daily dose of 150 mg during a lead-in period (7-14 days) and then increased to 250 mg daily in the absence of dose-limiting thrombocytopenia (

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Fichiers liés : 1-s2.0-S0090825822000488-am.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/03/2022
• Auteurs : J.-H. YvinecJean-bernard HuchetPierre MoretPhilippe Ponel
• Organismes : BioArchéologie, Interactions Sociétés Environnements Institut national de recherches archéologiques préventives Muséum national d'Histoire naturelle Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut méditerranéen de biodiversité et d'écologie marine et continentale
• Publié dans Les Nouvelles de l'archéologie le 26/10/2020

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Fichiers liés : Yvinec et al LesNouvellesdelArrcheologie 2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/03/2022
• Auteurs : Adrien ter SchiphorstRoxane PeresCyril DargazanliRaphaël BlancBenjamin GorySébastien RichardGaultier MarnatIgor SibonBenoit GuillonRomain BourcierChristian DenierLaurent SpelleJulien LabreucheArturo ConsoliBertrand LapergueVincent CostalatMichael ObadiaCaroline ArquizanGrégory GascouPierre-Henri LefèvreImad DerrazCarlos RiquelmeNicolas GaillardIsabelle MourandLucas CortiFederico CagnazzoAdrien WangSerge EvrardNadia AjiliDavid Weisenburger-LileLucas GorzaGéraldine BuardOguzhan CoskunFederico Di MariaGeorges RodeshSergio ZimatoreMorgan LeguenJulie GratieuxFernando PicoHaja RakotoharinandrasanaPhilippe TassanRoxanna PollSylvie MarinierSerge BracardRené AnxionnatMarc BraunAnne-Laure DerelleRomain TonneletLiang LiaoFrançois ZhuEmmanuelle SchmittSophie PlanelLisa HumbertjeanGioia MioneJean-Christophe LacourNolwenn Riou-ComteGérard AudibertMarcela VoicuLionel AlbMarie ReitterMadalina BrezeanuAgnès MassonAdriana TabarnaIona PodarFlorent GarielXavier BarreauJérôme BergeLouis VeunacPatrice MenegonLudovic LucasStéphane OlindoPauline RenouSharmila SagnierMathilde PoliSabrina DebruxellesFrançois RouanetThomas TourdiasJean-Sebastien LiegeyPierre BriauNicolas PangonLili DetrazBenjamin Daumas-DuportPierre-Louis AlexandreMonica RoyCédric LenobleHubert DesalSolène de GaalonCécile PreterreMichel PiotinHocine RedjemSimon EscalardJean-Philippe DesillesFrançois DelvoyeStanislas SmajdaBenjamin MaierMikaël MazighiMikael ObadiaCandice SabbenPierre SenersIgor RaynouardOvide CorabianuThomas de BrouckerEric ManchonGuillaume TaylorMalek Ben MaachaThion Laurie-AnneLecler AugustinSavatovsjy JulienOlivier ChassinVanessa ChalumeauJildaz CaroffOlivier ChassinLaura Venditti
• Organismes : Hôpital Gui de Chauliac [CHU Montpellier] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Neuroradiologie [Hôpital Gui de Chauliac] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Service de neurologie [CHRU Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Département de Neuro-Radiologie [Bordeaux] Institut de Neurosciences cognitives et intégratives d'Aquitaine Service de neurologie [Bordeaux] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Institut de Pathologie [CHU Lille] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Hôpital Foch [Suresnes] Hôpital Foch [Suresnes] Neuroradiologie [Hôpital Gui de Chauliac] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital Gui de Chauliac [CHU Montpellier]
• Publié dans Journal of Neurology le 01/11/2020

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Résumé : Background: The best treatment for acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (CICAO) (i.e., without associated occlusion of the circle of Willis) is still unknown. In this study, we aimed to describe EVT safety and clinical outcome in patients with CICAO. Methods: We analyzed data of all consecutive patients, included in the Endovascular Treatment in Ischemic Stroke (ETIS) Registry between 2013 and 2020, who presented AIS and proven CICAO on angiogram and underwent EVT. We assessed carotid recanalization, procedural complications, National Institutes of Health Stroke Scale (NIHSS) at 24 h post-EVT, and 3-month favorable outcome (modified Rankin Scale, mRS ≤ 2 or equal to the pre-stroke value). Results: Forty-five patients were included (median age: 70 years; range: 62-82 years). The median NIHSS before EVT was 14 (9-21). Carotid stenting was performed in 23 (51%) patients. Carotid recanalization at procedure end and on control imaging was observed in 37 (82%) and 29 (70%) patients, respectively. At day 1 post-EVT, the NIHSS remained stable or decreased in 25 (60%) patients; 12 (29%) patients had early neurologic deterioration (NIHSS ≥ 4 points). The rate of procedural complications was 36%, including stent thrombosis (n = 7), intracranial embolism (n = 7), and symptomatic intracranial hemorrhage (n = 1). At 3 months, 18 (40%) patients had a favorable outcome, and 10 (22%) were dead. Conclusion: Our study suggests that EVT in AIS patients with moderate/severe initial deficit due to CICAO led to high rate of recanalization at day 1, and a 40% rate of favorable outcome at 3 months. There was a high rate of procedural complication which is of concern. Randomized controlled trials assessing the superiority of EVT in patients with CICAO and severe deficits are needed.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/03/2022
• Auteurs : Pascal MartinBruno DlubakPierre SeneorRichard MattanaMarie-Blandine MartinPhilippe LafargeFrançois MalletMaria Luisa Della RoccaSimon M.‐m. DuboisJean‐christophe CharlierClément Barraud
• Organismes : Interfaces, Traitements, Organisation et Dynamique des Systèmes Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Matériaux et Phénomènes Quantiques Laboratoire Matériaux et Phénomènes Quantiques Laboratoire Matériaux et Phénomènes Quantiques Laboratoire Matériaux et Phénomènes Quantiques
• Publié dans Advanced Quantum Technologies le 13/01/2020

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Fichiers liés : Adv Quantum Tech - 2022 - Martin et al. OPEN-ACCESS.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 30/03/2022
• Auteurs : Vincent MartenotValentin MasdeuJean CupeFaustine GehinMargot BlanchonJulien DauriatAlexander HorstMichael RenaudinPhilippe GirardJean-Daniel Zucker
• Organismes : Quinten Quinten Quinten Quinten Quinten Quinten Swissmedic, Swiss Agency for Therapeutic Products Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] Nutrition et obésités: approches systémiques (UMR-S 1269)

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Résumé : Detecting safety signals attributed to a drug in scientific literature is a fundamental issue in pharmacovigilance. The constant increase in the volume of publications requires the automation of this tedious task, in order to find and extract relevant articles from the pack. This task is critical, as serious Adverse Drug Reactions (ADRs) still account for a large number of hospital admissions each year. The aim of this study is to develop an augmented intelligence methodology for automatically identifying relevant publications mentioning an established link between a Drug and a Serious Adverse Event, according to the European Medicines Agency (EMA) definition of seriousness. The proposed pipeline, called LiSA (for Literature Search Application), is based on three independent deep learning models supporting a precise detection of safety signals in the biomedical literature. By combining a Bidirectional Encoder Representations from Transformers (BERT) algorithms and a modular architecture, the pipeline achieves a precision of 0.81 and a recall of 0.89 at sentences level in articles extracted from PubMed (either abstract or full-text). We also measured that by using LiSA, a medical reviewer increases by a factor of 2.5 the number of relevant documents it can collect and evaluate compared to a simple keyword search. In the interest of re-usability, emphasis was placed on building a modular pipeline allowing the insertion of other NLP modules to enrich the results provided by the system, and extend it to other use cases. In addition, a lightweight visualization tool was developed to analyze and monitor safety signal results. Overall, the generic pipeline and the visualization tool proposed in this article allows for efficient and accurate monitoring of serious adverse drug reactions from the literature and can easily be adapted to similar pharmacovigilance use cases. To facilitate reproducibility and benefit other research studies, we also shared a first benchmark dataset for Serious Adverse Drug Events detection.

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Fichiers liés : LISA_SwissMedic_Paper (7).pdf

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• Type de publi. :
• Date de publi. : 29/03/2022
• Auteurs : Nathalie KorboulewskyPhilippe BalandierYves BoscardinOlivier ChaintreuilAdélie ChevalierCamille CouteauYann DumasMarion GosselinJean-Pierre HamardAviva KaraAnders MårellThomas PerotSandrine Perret
• Organismes : Ecosystèmes forestiers Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers

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Résumé : Presentation of OPTMix: OPTMix is an experimental site : 33 plots of 0.5 ha, on 40 ha (including buffer zone), even-aged, lowland temperate forest stands of 60-80 years old trees, equipped with sensors

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Fichiers liés : OPTMix_22_006_Korboulewsky_etal_OPTMixGeneral_mars2022.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 29/03/2022
• Auteurs : Clément KarsentyCéline Guilbeau-FrugierGaël GenetMarie-Hélène SeguelasPhilippe AlzieuOlivier CazorlaAlexandra MontagnerYuna BlumCaroline DubrocaJulie MaupointBlandine TramuntMarie CauquilThierry SulpiceSylvain RichardSilvia ArcucciRemy Flores-FloresNicolas PataluchRomain MontoriolPierre SicardAntoine DeneyThierry CouffinhalJean-Michel SénardCéline Galés
• Organismes : Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse University of Virginia School of Medicine [US] Institut des Maladies Métaboliques et Casdiovasculaires Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Institut des Maladies Métaboliques et Casdiovasculaires Institut de Génétique et Développement de Rennes Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Université Toulouse III - Paul Sabatier Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Institut des Maladies Métaboliques et Casdiovasculaires Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Centre Hospitalier Universitaire de Bordeaux Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires

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Résumé : Abstract RATIONALE In addition to its typical rod-shape, the mammalian adult cardiomyocyte (CM) harbors a unique lateral membrane surface architecture with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) the role of which is still unknown. OBJECTIVE To investigate the development and functional role of CM crests during the postnatal period. METHODS AND RESULTS Electron/confocal microscopy and western-blot of left ventricular tissues from rat hearts indicated a late CM surface crest maturation, between postnatal day 20 (P20) and P60, as shown by substantial SSM swelling and increased claudin-5 cell surface expression. The P20-P60 postnatal stage also correlates with an ultimate maturation of the T-Tubules and the intercalated disk. At the cellular level, we identified an atypical CM hypertrophy characterized by an increase in long- and short-axes without myofibril addition and with sarcomere lateral stretching, indicative of lateral stretch-based CM hypertrophy. We confirmed the P20-P60 hypertrophy at the organ level by echocardiography but also demonstrated a transcriptomic program after P20 targeting all the cardiac cell populations. At the functional level, using Doppler echocardiography, we found that the P20-P60 period is specifically dedicated to the improvement of relaxation. Mechanistically, using CM-specific knock-out mice, we identified ephrin-B1 as a determinant of CM crest maturation after P20 controlling lateral CM stretch-hypertrophy and relaxation. Interestingly, while young adult Efnb1 CMspe−/− mice essentially show a relaxation impairment with exercise intolerance, they progressively switch toward heart failure with 100% KO mice dying after 13 months. CONCLUSIONS This study highlights a new late P20-P60 postnatal developmental stage of the heart in rodents during which the CM surface crests mature through an ephrin-B1-dependant mechanism and regulate the diastolic function. Moreover, we demonstrate for the first time that the CM crest architecture is cardioprotective.

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Fichiers liés : 2022 Karsenty e al., Crest maturation.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/03/2022
• Auteurs : Morgane Guillou LandreatAntoine DanyGaëlle Challet-BoujuEdouard-Jules LaforgueJennifer CholetJuliette LeboucherJean-Benoit HardouinPierre BodenezBertrand Le GeayIsabelle MartineauPhilippe LevassorPaul BoloJean-Yves GuilletXavier GuilleryCorine DanoCaroline Victorri-VigneauMarie Grall-Bronnec
• Organismes : methodS in Patients-centered outcomes and HEalth ResEarch Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université methodS in Patients-centered outcomes and HEalth ResEarch methodS in Patients-centered outcomes and HEalth ResEarch Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France methodS in Patients-centered outcomes and HEalth ResEarch Université de Brest Department of Prison Psychiatry [Nantes] Centre Hospitalier Universitaire d'Angers methodS in Patients-centered outcomes and HEalth ResEarch Service de Pharmacologie Clinique [CHU Nantes] methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Harm Reduction Journal le 29/10/2020

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Résumé : Abstract Background The resurgence of heroin use and the misuse of pharmaceutical opioids are some of the reasons for a worldwide increase in opioid dependence. Opioid Medication Therapies (OMT) have amply demonstrated their efficacy. From a medical point of view, the main objectives of OMT concern medical and social outcomes, centred on risk reduction and the cessation of opioid use. But patient points of view can differ and few studies have explored opioid-dependent patient viewpoints on their OMT. This variable seems important to consider in a patient-centred approach. The aim of our study was to explore points of view of people who use drugs (PWUD) treated with OMT, in a large multicentre sample. Method A cross-sectional multicentre study explored the points of view of PWUD with Opioid Use Disorder following OMT. Data regarding the patients’ points of view were collected using a self-administered questionnaire developed by the scientific committee of the study. A descriptive analysis and an exploratory factor analysis were performed to explore the structure of items exploring patient viewpoints. Results 263 opioid dependent PWUD were included, a majority were men consuming heroin prior to being prescribed OMT. 68% were on methadone, 32% were on buprenorphine. Most PWUD identified a positive impact on their lives, with 92.8% agreeing or strongly agreeing that OMT had changed a lot of things in their lives. The exploratory factor analysis identified three factors: (F1) items related to points of views concerning the objectives and efficacy of OMT; (F2) items related to the legitimacy of OMT as a treatment compared to a drug, (F3) items related to experiences and relationships with OMT. Conclusion Patient viewpoints on efficacy were correlated with the pharmacological benefits of OMT and with the associated psychosocial measures. The implications of OMT in relationships, such as the feeling of being judged, concerned a majority. Points of view were ambivalent concerning the role of OMT as a treatment or as a drug. Involving patient points of view in therapeutic strategies decisions could help enhance positive views among PWUD on OMT and help PWUD towards their recovery. Trial registration: OPAL study was registered: (NCT01847729).

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Fichiers liés : main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/03/2022
• Auteurs : Philippe ColombanBurcu Kirmizi
• Organismes : De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies Laboratoire de Dynamique Interactions et Réactivité Laboratoire de Physique de la Matière Condensée Department of Conservation and Restoration of Cultural Property, Faculty of Architecture, Yıldız Technical University, Yıldız Yerleşkesi B Blok, Beşiktaş, 34349 Istanbul, Turkey

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Résumé : Enamelling, i.e. coating of a substrate with a layer of glass by firing, is one of the most sophisticated technologies developed to decorate artefacts. China has a long expertise in the production of ceramics and glass but for technical and aesthetic reasons, 17th century (Ming Dynasty and then Kangxi reign) Chinese decors were rather similar to those obtained on paper with lavish or watercolour techniques. These productions did not permit to represent a ‘realistic’ decor, as prepared on majolica, (soft-paste)porcelain and metal wares by European craftsmen who were capable of making copies of famous paintings. Actually, much information about the ingredients and production process remain imprinted in the matter accessible by spectroscopical methods, Raman and X-ray fluorescence spectroscopy. The rareness and high value of artefacts, particularly those made at the Imperial Palace under the guidance of (Jesuit) European masters, require the use of non-invasive mobile instruments. We present here an overview of the analytical study of French (enamelled watches, Limoges wares, soft-paste porcelain, etc.) and Chinese (wucai, fengcai, falangcai, huafalang, cloisonné etc.) artefacts prepared during the 17th and first part of the 18th century (Qing Dynasty). We are able to identify the first use of European ingredients (blue As-rich cobalt, white cassiterite) and recipes (purple-red Perrot’ gold nanoparticles, Naples yellow lead pyrochlore type pigments) for the preparation of ‘realistic’ decors on Chinese ceramics and enamels, which shed light on the technological exchange between Europe and China. The results are significant in terms of comparison with the written records analyzed by historians. COLOMBAN Philippe, ZHANG Yizheng, ZHAO Bing, « Non-invasive Raman analyses of huafalang and related porcelain wares. Searching for evidence for innovative pigment technologies », Ceramics International 43(15), 2017, 12079-12088. COLOMBAN Philippe, KIRMIZI Burcu, ZHAO Bing, CLAIS Jean-Baptiste, YANG Yong, DROGUET Vincent, « Non-invasive on-site Raman study of pigments and glassy matrix of 17th-18th Century painted enamelled Chinese metal wares : Comparaison with French enamelling technology » Coatings, 10, 2020, 471. COLOMBAN Philippe, KIRMIZI Burcu, ZHAO Bing, CLAIS Jean-Baptiste, YANG Yong, DROGUET Vincent, « Investigation of the pigments and glassy matrix of painted enamelled Qing Dynasty Chinese porcelains by noninvasive on-site Raman microspectroscopy, Heritage 3(3), 2020, 915-940. COLOMBAN Philippe, KIRMIZI Burcu, GOUGEON Catherine, GIRONDA Michele, CARDINAL Catherine, « Pigments and glassy matrix of the 17th-18th century enamelled French watches: A non-invasive on-site Raman and pXRF study » Journal of Cultural Heritage 2020, 44, 1-14. COLOMBAN Philippe, KIRMIZI Burcu, SIMSEK FRANCI Gulsu, « Cobalt and Associated Impurities in Blue (and Green) Glass, Glaze and Enamel: Relationships between Raw Materials, Processing, Composition, Phases and International Trade » Minerals, 11, 2021, 633. COLOMBAN Philippe, GIRONDA Michele, VANGU Divine, KIRMIZI Burcu, ZHAO Bing, COCHET Vincent, « The technology transfer from Europe to China in the 17th-18th centuries: Non-invasive on-site XRF and Raman analyses of Chinese Qing Dynasty enameled masterpieces made using European ingredients/recipes” Materials, 2021, 14, 7434

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• Type de publi. : Article dans une revue
• Date de publi. : 25/03/2022
• Auteurs : Jean PersonnazEnzo PiccoloAlizée DortignacJason IacovoniJérôme J. MarietteVincent RocherArnaud PolizziAurélie BatutSimon DeleruyelleLucas BourdensOcéane DelosLucie Combes-SoiaRomain PaccoudElsa MoreauFrédéric MartinsThomas ClouaireFadila BenhamedAlexandra MontagnerWalter WahliRobert F. SchwabeArmelle YartIsabelle Castan-LaurellJustine Bertrand-MichelOdile Burlet-SchiltzCatherine PosticPierre-Damien DenechaudCédric MoroGaëlle LegubeChih-Hao LeeHervé GuillouPhilippe P. ValetCedric DrayJean-Philippe Pradère
• Organismes : Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Unité de Mathématiques et Informatique Appliquées de Toulouse SIAAP - Direction du Développement et de la Prospective Toxicologie Intégrative & Métabolisme Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut de pharmacologie et de biologie structurale Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Plateforme Génome & Transcriptome Unité de biologie Moléculaire, Cellulaire et du Développement Institut Cochin Institut des Maladies Métaboliques et Casdiovasculaires Unité de biologie Moléculaire, Cellulaire et du Développement Center for Integrative Genomics - Institute of Bioinformatics, Génopode Lee Kong Chian School of Medicine [Nanyang Technological University] Columbia University [New York] Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut de pharmacologie et de biologie structurale Institut Cochin Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Unité de biologie Moléculaire, Cellulaire et du Développement Harvard T.H. Chan School of Public Health Toxicologie Intégrative & Métabolisme Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires
• Publié dans Science Advances le 21/10/2020

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Résumé : Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very complex and fine-tuned by chromatin dynamics and multiple key transcription factors. Here, we demonstrate that the nuclear factor HMGB1 acts as a strong repressor of liver lipogenesis. Mice with liver-specific Hmgb1 deficiency display exacerbated liver steatosis, while Hmgb1 -overexpressing mice exhibited a protection from fatty liver progression when subjected to nutritional stress. Global transcriptome and functional analysis revealed that the deletion of Hmgb1 gene enhances LXRα and PPARγ activity. HMGB1 repression is not mediated through nucleosome landscape reorganization but rather via a preferential DNA occupation in a region carrying genes regulated by LXRα and PPARγ. Together, these findings suggest that hepatocellular HMGB1 protects from liver steatosis development. HMGB1 may constitute a new attractive option to therapeutically target the LXRα-PPARγ axis during NAFLD.

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Fichiers liés : sciadv.abg9055.pdf

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