Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 25/03/2022
• Auteurs : Mathieu LesouhaitierMurielle GregoireArnaud GacouinValentin CoirierAurelien FrerouCaroline PiauVincent CattoirErwan DumontetMatthieu RevestPierre TattevinAntoine RoisneJean-Philippe VerhoyeErwan FlecherYves Le TulzoKarin TarteJean-Marc Tadie
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN régulateurs bactériens et médecine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer
• Publié dans Journal of Leukocyte Biology le 26/10/2020

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Résumé : Staphylococcus aureus is the main bacterial pathogen encountered in mediastinitis after cardiac surgical procedures; it remains a devastating complication with a high mortality rate. As neutrophils have a primordial role in the defense against staphylococcus infection and cardiopulmonary bypass (CPB) is known to induce immunosuppression, the aim of this study was to investigate CPB impact on neutrophil functions. Patients without known immunosuppression scheduled for cardiac surgery with CPB were included. Bone marrow and blood samples were harvested before, during, and after surgery. Neutrophil phenotypic maturation and functions (migration, adhesion, neutrophil extracellular trap [NET] release, reactive oxygen species (ROS) production, phagocytosis, and bacteria killing) were investigated. Two types of Staphylococcus aureus strains (one from asymptomatic nasal carriage and another from mediastinitis infected tissues) were used to assess in vitro bacterial direct impact on neutrophils. We found that CPB induced a systemic inflammation with an increase in circulating mature neutrophils after surgery. Bone marrow sample analysis did not reveal any modification of neutrophil maturation during CPB. Neutrophil lifespan was significantly increased and functions such as NET release and ROS production were enhanced after CPB whereas bacteria killing and phagocytosis were not impacted. Results were similar with the two different isolates of Staphylococcus aureus. These data suggest that CPB induces a recruitment of mature neutrophils via a demargination process rather than impacting their maturation in the bone marrow. In addition, neutrophils are fully efficient after CPB and do not contribute to postoperative immunosuppression.

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Fichiers liés : Lesouhaitier et al - 2021 - Neutrophil function and bactericidal activity against Staphylococcus aureus.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/03/2022
• Auteurs : Annie OuinÉmilie AndrieuGerard BalentRomain CarriéJean-Philippe ChoisisJean-François DejouxJean-Pierre del CorsoJames DesaegherMathieu FauvelNicola GallaiSylvie LadetJustine Rivers-MooreZafarani UwingabireDavid SheerenAude VialatteBarbara Cichosz
• Organismes : Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Centre for Environmental and Climate Research [Lund] Dynamiques et écologie des paysages agriforestiers Systèmes d'élevage méditerranéens et tropicaux Centre d'études spatiales de la biosphère Laboratoire d'Etude et de Recherche sur l'Economie, les Politiques et les Systèmes Sociaux Dynamiques et écologie des paysages agriforestiers Centre d'études spatiales de la biosphère Laboratoire d'Etude et de Recherche sur l'Economie, les Politiques et les Systèmes Sociaux Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Laboratoire d'Etude et de Recherche sur l'Economie, les Politiques et les Systèmes Sociaux Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Chambre Régionale d'Agriculture d'Occitanie
• Publié dans Innovations Agronomiques le 24/10/2020

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Résumé : Le projet PSDR4 Sebioref avait pour objectif de qualifier le service écosystémique de pollinisation rendu par la biodiversité, et d’identifier les leviers paysagers pour améliorer ce service de pollinisation. In fine, l’objectif était d’envisager des coordinations entre producteurs et utilisateurs potentiels de services écosystémiques à l’échelle des territoires. Il a été mené par trois laboratoires (Dynafor, Cesbio, Lereps) et co-animé avec la Chambre Régionale d’Agriculture d’Occitanie. Le projet Sebioref a fourni des outils en télédétection pour l’identification des ressources florales dans les prairies sur de larges étendues, la modélisation spatialisée du processus de pollinisation et de concertation entre les acteurs. Nous avons montré que le service écosystémique de pollinisation, notamment vis à vis des cultures entomophiles, nécessitait une approche paysagère pour permettre la complémentarité entre les ressources florales présentes dans les haies, lisières de bois et prairies. Ainsi, la transition agro-écologique devra intégrer les échelles paysagères et territoriales. Nous avons aussi montré que les acteurs du territoire étudié sont très concernés par la protection des espèces d’abeilles sauvages et sont sources de propositions pour favoriser cette diversité et les services qu’elle rend. L’action collective semble donc être la plus à même de répondre aux attentes des acteurs dans la gestion d’un paysage qui produit et offre une multitude de services.

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Fichiers liés : 2022-OUIN-12_IA_Vol86.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 24/03/2022
• Auteurs : Christophe Le TerrierFlorian SigaudSaid LebbahLuc DesmedtDavid HajageClaude GuérinJérôme PuginSteve PrimmazNicolas TerziAlain MercatPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PreauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DésertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonniereDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérôme PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSebastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultElie AzoulayMichael DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGael PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Service de Réanimation Médicale [Grenoble] Centre de pharmacoépidémiologie AP-HP Service d'anesthésie et réanimation chirurgicale [Nantes] Centre de pharmacoépidémiologie AP-HP Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Centre Hospitalier Universitaire [CHU Grenoble] Hypoxie et PhysioPathologie Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Université d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire d'Angers Fédération de Médecine Translationnelle de Strasbourg Nanomédecine Régénérative Centre de recherche en épidémiologie et santé des populations Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Université Paris-Saclay Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] [GIN] Grenoble Institut des Neurosciences Université Grenoble Alpes [GIN] Grenoble Institut des Neurosciences
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19. Methods: All intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgium and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score. Results: Among 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay and 491 (23%) during the first 24 h following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO2/FiO2 ratio > 150 mmHg when prone positioning was initiated. Among non-early PP group patients, 1013 (47.4%) patients had finally been placed in PP within a median delay of 3 days after ICU admission. Day-60 mortality in non-early PP group was 34.2% versus 39.3% in the early PP group (p = 0.038). Day-28 and Day-90 mortality as well as the need for adjunctive therapies was more important in patients with early PP. After propensity score adjustment, no significant difference in survival at Day-60 was found between the two study groups (HR 1.34 [0.96-1.68], p = 0.09 and HR 1.19 [0.998-1.412], p = 0.053 in complete case analysis or in multiple imputation analysis, respectively). Conclusions: In a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, our data failed to show a survival benefit associated with early PP started within 24 h after ICU admission compared to PP after day-1 for all COVID-19 patients requiring invasive mechanical ventilation regardless of their severity.

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Fichiers liés : Le Terrier_2022.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 24/03/2022
• Auteurs : Christophe Le TerrierFlorian SigaudSaid LebbahLuc DesmedtDavid HajageClaude GuérinJérôme PuginSteve PrimmazNicolas TerziAlain MercatPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PréauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DésertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonniereDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérôme PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSébastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultÉlie AzoulayMichael DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGael PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19. Methods All intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgium and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score. Results Among 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay and 491 (23%) during the first 24 h following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO 2 /FiO 2 ratio > 150 mmHg when prone positioning was initiated. Among non-early PP group patients, 1013 (47.4%) patients had finally been placed in PP within a median delay of 3 days after ICU admission. Day-60 mortality in non-early PP group was 34.2% versus 39.3% in the early PP group ( p = 0.038). Day-28 and Day-90 mortality as well as the need for adjunctive therapies was more important in patients with early PP. After propensity score adjustment, no significant difference in survival at Day-60 was found between the two study groups (HR 1.34 [0.96–1.68], p = 0.09 and HR 1.19 [0.998–1.412], p = 0.053 in complete case analysis or in multiple imputation analysis, respectively). Conclusions In a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, our data failed to show a survival benefit associated with early PP started within 24 h after ICU admission compared to PP after day-1 for all COVID-19 patients requiring invasive mechanical ventilation regardless of their severity.

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• Type de publi. : Article dans une revue
• Date de publi. : 24/03/2022
• Auteurs : Elizabeth CurtisJean‐yves ReginsterNasser Al-DaghriEmmanuel BiverMaria Luisa BrandiEtienne CavalierPeyman HadjiPhilippe HalboutNicholas HarveyMickaël HiligsmannMuhammad Kassim JavaidJ.A. KanisJean-Marc KaufmanOlivier LamyRadmila MatijevicAdolfo Diez PerezRégis Pierre RadermeckerMário Miguel RosaThierry ThomasFriederike ThomasiusMila VlaskovskaRené RizzoliC. Cooper
• Organismes : Santé Ingénierie Biologie Saint-Etienne
• Publié dans Aging Clinical and Experimental Research le 27/10/2020

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Résumé : Abstract Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment and a range of effective pharmacological agents. Currently, bone-forming (anabolic) agents, in many countries, are used in those patients who have continued to lose bone mineral density (BMD), patients with multiple subsequent fractures or those who have fractured despite treatment with antiresorptive agents. However, head-to-head data suggest that anabolic agents have greater rapidity and efficacy for fracture risk reduction than do antiresorptive therapies. The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) convened an expert working group to discuss the tools available to identify patients at high risk of fracture, review the evidence for the use of anabolic agents as the initial intervention in patients at highest risk of fracture and consider the sequence of therapy following their use. This position paper sets out the findings of the group and the consequent recommendations. The key conclusion is that the current evidence base supports an “anabolic first” approach in patients found to be at very high risk of fracture, followed by maintenance therapy using an antiresorptive agent, and with the subsequent need for antiosteoporosis therapy addressed over a lifetime horizon.

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• Type de publi. : Article dans une revue
• Date de publi. : 23/03/2022
• Auteurs : Elia StahlAngel Fernandez MartinGaétan GlauserMarie-Charlotte GuillouSébastien AubourgJean-Pierre RenouPhilippe Reymond
• Organismes :
• Publié dans Frontiers in Plant Science le 24/10/2020

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Résumé : Initiation of plant immune signaling requires recognition of conserved molecular patterns from microbes and herbivores by plasma membrane-localized pattern recognition receptors. Additionally, plants produce and secrete numerous small peptide hormones, termed phytocytokines, which act as secondary danger signals to modulate immunity. In Arabidopsis, the Brassicae -specific SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) family consists of 14 members that are perceived by the leucine-rich repeat receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2). Recognition of SCOOP peptides elicits generic early signaling responses but knowledge on how and if SCOOPs modulate specific downstream immune defenses is limited. We report here that depletion of MIK2 or the single PROSCOOP12 precursor results in decreased Arabidopsis resistance against the generalist herbivore Spodoptera littoralis but not the specialist Pieris brassicae. Increased performance of S. littoralis on mik2-1 and proscoop12 is accompanied by a diminished accumulation of jasmonic acid, jasmonate-isoleucine and indolic glucosinolates. Additionally, we show transcriptional activation of the PROSCOOP gene family in response to insect herbivory. Our data therefore indicate that perception of endogenous SCOOP peptides by MIK2 modulates the jasmonate pathway and thereby contributes to enhanced defense against a generalist herbivore.

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Fichiers liés : 2022_Stahl_Front.Plant.Sci..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/03/2022
• Auteurs : Benoit BrillandCharlotte Boud’horsMarie-Christine CopinPierre JourdainNicolas HenrySamuel WacrenierAssia DjemaClément SamoreauJean-Philippe CoindreMaud CousinJeremie RiouAnne CroueJean-Paul Saint-AndréJean-François SubraGiorgina Barbara PiccoliJf Augusto
• Organismes : Centre Hospitalier Universitaire d'Angers Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier de Laval Centre Hospitalier Universitaire d'Angers Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier de Cholet Centre Hospitalier Universitaire d'Angers Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire d'Angers Micro et Nanomédecines Translationnelles Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Service Néphrologie [CH Le Mans] Centre Hospitalier Universitaire d'Angers Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques
• Publié dans Frontiers in Immunology le 25/10/2020

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Résumé : Introduction The “Renal Risk Score” (RRS) and the histopathological classification have been proposed to predict the risk of end-stage kidney disease (ESKD) in ANCA-associated glomerulonephritis (ANCA-GN). Besides, factors associated with kidney function recovery after ANCA-GN onset remain to be more extensively studied. In the present study, we analyzed the value of the RRS and of the histopathological classification for ESKD prediction. Next, we analyzed factors associated with eGFR change within the first 2 years following ANCA-GN diagnosis. Materials and Methods We included patients from the Maine–Anjou ANCA-associated vasculitis registry with at least 6 months of follow-up. The values of ANCA-GN, histopathological classification, and RRS, and the factors associated with eGFR variations between ANCA-GN diagnosis and 2 years of follow-up were assessed. Results The predictive values of the histopathological classification and RRS were analyzed in 123 patients. After a median follow-up of 42 months, 33.3% patients developed ESKD. The predictive value of RRS for ESKD was greater than that of the histopathological classification. Determinants of eGFR variation were assessed in 80/123 patients with complete eGFR measurement. The median eGFR increased from ANCA-GN diagnosis to month 6 and stabilized thereafter. The only factor associated with eGFR variation in our study was eGFR at ANCA-GN diagnosis, with higher eGFR at diagnosis being associated with eGFR loss (p<0.001). Conclusion The RRS has a better predictive value for ESKD than the histopathological classification. The main determinant of eGFR variation at 2 years was eGFR at ANCA-GN diagnosis. Thus, this study suggests that eGFR recovery is poorly predicted by histological damage at ANCA-GN diagnosis.

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Fichiers liés : fimmu-13-834878.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 18/03/2022
• Auteurs : Romain HanyJean-Philippe LeyrisGuillaume BretSylvie MalliéChamroeun SarMaxime ThouayeAbdallah HamzeOlivier ProvotPierre SokoloffJean ValmierPascal VillaDidier Rognan
• Organismes : Plateforme de chimie biologique intégrative de Strasbourg Institut des Neurosciences de Montpellier BIODOL Therapeutics [Clapiers] Laboratoire d'Innovation Thérapeutique Institut des Neurosciences de Montpellier Institut des Neurosciences de Montpellier Institut des Neurosciences de Montpellier Biomolécules : Conception, Isolement, Synthèse Biomolécules : Conception, Isolement, Synthèse BIODOL Therapeutics [Clapiers] Institut des Neurosciences de Montpellier Plateforme de chimie biologique intégrative de Strasbourg Laboratoire d'Innovation Thérapeutique
• Publié dans ACS Chemical Biology le 25/10/2020

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Résumé : nhibiting receptor tyrosine kinases is commonly achieved by two main strategies targeting either the intracellular kinase domain by low molecular weight compounds or the extracellular ligand-binding domain by monoclonal antibodies. Identifying small molecules able to inhibit RTKs at the extracellular level would be highly desirable to gain exquisite selectivity but is believed to be challenging owing to the size of RTK endogenous ligands (cytokines, growth factors) and the topology of RTK extracellular domains. We here report the high-throughput screening of the French Chemical Library (48K compounds) for extracellular inhibitors of the Fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase, by a homogeneous time-resolved fluorescence competition assay. A total of 679 small molecular weight ligands (1.4%) were confirmed to strongly inhibit (>75%) the binding of the fluorescent labeled FLT3 ligand (FL cytokine) to FLT3 overexpressed in HEK-293 cells, at two different concentrations (5 and 20 μM). Concentration-response curves, obtained for 111 lead-like molecules, confirmed the unexpected tolerance of the FLT3 extracellular domain for low molecular weight druggable inhibitors exhibiting submicromolar potencies, chemical diversity, and promising pharmacokinetic properties. Further investigation of one hit confirmed inhibitory properties in dorsal root ganglia neurons and in a mouse model of neuropathic pain.

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Fichiers liés : revised.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 18/03/2022
• Auteurs : Raphael Romano BrunoBernhard WernlyHans FlaattenJesper FjølnerAntonio ArtigasPhilipp Heinrich BaldiaStephan BinneboesselBernardo Bollen PintoJoerg SchefoldGeorg WolffMalte KelmMichael BeilSigal SviriPeter Vernon van HeerdenWojciech SzczeklikMuhammed ElhadiMichael JoannidisSandra OeyenEumorfia KondiliBrian MarshJakob WollbornFinn AndersenRui MorenoSusannah LeaverAriane BoumendilDylan de LangeBertrand GuidetChristian JungPhilipp EllerMichael JoannidisDieter MesottenPascal ReperSandra OeyenWalter SwinnenNicolas SerckElisabeth DewaeleHelene BrixJens BrushoejPritpal KumarHelene Korvenius NedergaardIda Riise BallebyCamilla BundesenMaria Aagaard HansenStine UhrenholtHelle BundgaardJesper FjølnerJames GoochLenka CagovaElizabeth PotterMichael ReayMiriam DaveyMohammed Abdelshafy AbusayedSally HumphreysArnaud GalboisBertrand GuidetCyril CharronCaroline Hauw BerlemontGuillaume BeschJean-Philippe RigaudJulien MaizelMichel DjibréPhilippe BurtinPierre GarconSaad NseirXavier ValetteNica AlexandruNathalie MarinMarie VaissiereGaëtan PlantefeveThierry VanderlindenIgor JurcisinBuno MegarbaneBenjamin ChoustermanFrançois DépretMarc GarnierSebastien BessetJohanna OzielAlexis FerreStéphane DaugerGuillaume DumasBruno GoncalvesLucie VettorettiDidier TheveninStefan SchallerMuhammed KurtAndreas FaltlhauserChristian MeyerMilena MilovanovicMatthias LutzGonxhe ShalaHendrik HaakeWinfried RanderathAnselm KunsteinPatrick MeybohmStephan SteinerEberhard BarthTudor PoernerPhilipp SimonMarco LorenzZouhir DindaneKarl Friedrich KuhnMartin WelteIngo VoigtHans-Joachim KabitzJakob WollbornUlrich GoebelSandra Emily StollDetlef Kindgen-MillesSimon DublerChristian JungKristina FuestMichael SchusterAntonios PapadogoulasFrancesk MulitaNikoletta RovinaZoi AidoniEvangelia ChrisanthopoulouEumorfia KondiliIoannis AndrianopoulosMartijn GroenendijkMirjam EversLenneke van Lelyveld-HaasIwan MeynaarAlexander Daniel CornetMarieke ZegersWillem DieperinkDylan de LangeTom DormansMichael HahnBritt SjøbøeHans Frank StrietzelTheresa OlasveengenLuis RomundstadFinn AndersenAnna KluzikPaweł ZatorskiTomasz DrygalskiWojciech SzczeklikJakub KlimkiewiczJoanna Solek-PastuszkaDariusz OnichimowskiMiroslaw CzuczwarRyszard GawdaJan StefaniakKarina Stefanska-WronkaEwa ZabulAna Isabel Pinho OliveiraRui AssisMaria de Lurdes Campos SantosHenrique SantosFilipe Sousa CardosoAndré GordinhoMaria José Arche BanzoBegoña Zalba-EtayoPatricia Patricia CuberoJesús PriegoGemma GomàTeresa Maria Tomasa-IrriguibleSusana SanchoAida Fernández FerreiraEric Mayor VázquezÁngela Prado MiraMercedes IbarzDavid IglesiasSusana Arias-RiveraFernando Frutos-VivarSonia Lopez-CuencaCesar AldecoaDavid Perez-TorresIsabel Canas-PerezLuis Tamayo-LomasCristina Diaz-RodriguezPablo Ruiz de GopeguiNawfel Ben-HamoudaAndrea RobertiYvan FleuryNour AbidiJoerg SchefoldIvan ChauAlexander DullenkopfRichard PughSara Smuts
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Purpose Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group. Methods The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 = no disability), Clinical Frailty Scale (CFS), SOFA score, intensive care treatment, ICU- and 3-month survival were recorded. A mixed-effects Weibull proportional hazard regression analyses for 3-month mortality adjusted for multiple confounders. Results This pre-specified analysis included 2359 patients with a documented ADL and CFS. Most patients evidenced independence in their daily living before hospital admission (80% with ADL = 6). Patients with no frailty and no disability showed the lowest, patients with frailty (CFS ≥ 5) and disability (ADL < 6) the highest 3-month mortality (52 vs. 78%, p < 0.001). ADL was independently associated with 3-month mortality (ADL as a continuous variable: aHR 0.88 (95% CI 0.82–0.94, p < 0.001). Being “disable” resulted in a significant increased risk for 3-month mortality (aHR 1.53 (95% CI 1.19–1.97, p 0.001) even after adjustment for multiple confounders. Conclusion Baseline Activities of Daily Living (ADL) on admission provides additional information for outcome prediction, although most critically ill old intensive care patients suffering from COVID-19 had no restriction in their ADL prior to ICU admission. Combining frailty and disability identifies a subgroup with particularly high mortality. Trial registration number: NCT04321265. Graphical Abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 17/03/2022
• Auteurs : Marine BaronCathia SouliéArmelle LavoléLambert AssoumouBaptiste AbbarFouquet BAlice RousseauMarianne VeyriAssia SamriAlain MakinsonSylvain ChoquetJulien MazièresSolenn BrosseauBrigitte AutranDominique CostagliolaChristine KatlamaJacques CadranelAnne-Geneviève MarcelinOlivier LambotteJean-Philippe SpanoAmélie Guihot
• Organismes : Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules CHU Tenon [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière] Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière] Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière] Département Maladies Infectieuses et Tropicales [CHRU Montpellier] CHU Pitié-Salpêtrière [AP-HP] Service de pneumologie [Toulouse] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules CHU Tenon [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Service de Médecine Interne - Immunologie Clinique [AP-HP Bicêtre] Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Sorbonne Université - Faculté de médecine [CHU Pitié Salpétrière]
• Publié dans Cells le 01/11/2020

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Résumé : The role of immune checkpoints (ICPs) in both anti-HIV T cell exhaustion and HIV reservoir persistence, has suggested that an HIV cure therapeutic strategy could involve ICP blockade. We studied the impact of anti-PD-1 therapy on HIV reservoirs and anti-viral immune responses in people living with HIV and treated for cancer. At several timepoints, we monitored CD4 cell counts, plasma HIV-RNA, cell associated (CA) HIV-DNA, EBV, CMV, HBV, HCV, and HHV-8 viral loads, activation markers, ICP expression and virus-specific T cells. Thirty-two patients were included, with median follow-up of 5 months. The CA HIV-DNA tended to decrease before cycle 2 (p = 0.049). Six patients exhibited a ≥0.5 log10 HIV-DNA decrease at least once. Among those, HIV-DNA became undetectable for 10 months in one patient. Overall, no significant increase in HIV-specific immunity was observed. In contrast, we detected an early increase in CTLA-4 + CD4+ T cells in all patients (p = 0.004) and a greater increase in CTLA-4+ and TIM-3 + CD8+ T cells in patients without HIV-DNA reduction compared to the others (p ≤ 0.03). Our results suggest that ICP replacement compensatory mechanisms might limit the impact of anti-PD-1 monotherapy on HIV reservoirs, and pave the way for combination ICP blockade in HIV cure strategies.

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Fichiers liés : cells-11-01015-v2.pdf

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