Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 30/03/2022
• Auteurs : Pascal MartinBruno DlubakPierre SeneorRichard MattanaMarie-Blandine MartinPhilippe LafargeFrançois MalletMaria Luisa Della RoccaSimon M.‐m. DuboisJean‐christophe CharlierClément Barraud
• Organismes : Interfaces, Traitements, Organisation et Dynamique des Systèmes Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Matériaux et Phénomènes Quantiques Laboratoire Matériaux et Phénomènes Quantiques Laboratoire Matériaux et Phénomènes Quantiques Laboratoire Matériaux et Phénomènes Quantiques
• Publié dans Advanced Quantum Technologies le 13/01/2020

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Fichiers liés : Adv Quantum Tech - 2022 - Martin et al. OPEN-ACCESS.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/03/2022
• Auteurs : Nicolas NesselerGuillaume FadelAlexandre MansourMarylou ParaPierre-Emmanuel FalcozNicolas MongardonAlizée PortoAstrid BertierBruno LevyCyril CadozPierre-Grégoire GuinotOlivier FouquetJean-Luc FellahiAlexandre OuattaraJulien GuihaireVito-Giovanni RuggieriPhilippe GaudardFrançois LabasteThomas ClavierKais BriniNicolas AllouCorentin LacroixJuliette ChommelouxGuillaume LebretonMichael MatthaySophie ProvenchereErwan FlécherAndré Vincentelli
• Organismes : Méthodes particulaires utilisant Monge-Ampère Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
• Publié dans Anesthesiology le 26/10/2020

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Résumé : Background Despite expanding use, knowledge on extracorporeal membrane oxygenation support during the COVID-19 pandemic remains limited. The objective was to report characteristics, management, and outcomes of patients receiving extracorporeal membrane oxygenation with a diagnosis of COVID-19 in France and to identify pre-extracorporeal membrane oxygenation factors associated with in-hospital mortality. A hypothesis of similar mortality rates and risk factors for COVID-19 and non–COVID-19 patients on venovenous extracorporeal membrane oxygenation was made. Methods The Extracorporeal Membrane Oxygenation for Respiratory Failure and/or Heart failure related to Severe Acute Respiratory Syndrome-Coronavirus 2 (ECMOSARS) registry included COVID-19 patients supported by extracorporeal membrane oxygenation in France. This study analyzed patients included in this registry up to October 25, 2020, and supported by venovenous extracorporeal membrane oxygenation for respiratory failure with a minimum follow-up of 28 days after cannulation. The primary outcome was in-hospital mortality. Risk factors for in-hospital mortality were analyzed. Results Among 494 extracorporeal membrane oxygenation patients included in the registry, 429 were initially supported by venovenous extracorporeal membrane oxygenation and followed for at least 28 days. The median (interquartile range) age was 54 yr (46 to 60 yr), and 338 of 429 (79%) were men. Management before extracorporeal membrane oxygenation cannulation included prone positioning for 411 of 429 (96%), neuromuscular blockage for 419 of 427 (98%), and NO for 161 of 401 (40%). A total of 192 of 429 (45%) patients were cannulated by a mobile extracorporeal membrane oxygenation unit. In-hospital mortality was 219 of 429 (51%), with a median follow-up of 49 days (33 to 70 days). Among pre-extracorporeal membrane oxygenation modifiable exposure variables, neuromuscular blockage use (hazard ratio, 0.286; 95% CI, 0.101 to 0.81) and duration of ventilation (more than 7 days compared to less than 2 days; hazard ratio, 1.74; 95% CI, 1.07 to 2.83) were independently associated with in-hospital mortality. Both age (per 10-yr increase; hazard ratio, 1.27; 95% CI, 1.07 to 1.50) and total bilirubin at cannulation (6.0 mg/dl or more compared to less than 1.2 mg/dl; hazard ratio, 2.65; 95% CI, 1.09 to 6.5) were confounders significantly associated with in-hospital mortality. Conclusions In-hospital mortality was higher than recently reported, but nearly half of the patients survived. A high proportion of patients were cannulated by a mobile extracorporeal membrane oxygenation unit. Several factors associated with mortality were identified. Venovenous extracorporeal membrane oxygenation support should be considered early within the first week of mechanical ventilation initiation. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

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• Type de publi. :
• Date de publi. : 29/03/2022
• Auteurs : Nathalie KorboulewskyPhilippe BalandierYves BoscardinOlivier ChaintreuilAdélie ChevalierCamille CouteauYann DumasMarion GosselinJean-Pierre HamardAviva KaraAnders MårellThomas PerotSandrine Perret
• Organismes : Ecosystèmes forestiers Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers

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Résumé : Presentation of OPTMix: OPTMix is an experimental site : 33 plots of 0.5 ha, on 40 ha (including buffer zone), even-aged, lowland temperate forest stands of 60-80 years old trees, equipped with sensors

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Fichiers liés : OPTMix_22_006_Korboulewsky_etal_OPTMixGeneral_mars2022.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 29/03/2022
• Auteurs : Clément KarsentyCéline Guilbeau-FrugierGaël GenetMarie-Hélène SeguelasPhilippe AlzieuOlivier CazorlaAlexandra MontagnerYuna BlumCaroline DubrocaJulie MaupointBlandine TramuntMarie CauquilThierry SulpiceSylvain RichardSilvia ArcucciRemy Flores-FloresNicolas PataluchRomain MontoriolPierre SicardAntoine DeneyThierry CouffinhalJean-Michel SénardCéline Galés
• Organismes : Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse University of Virginia School of Medicine [US] Institut des Maladies Métaboliques et Casdiovasculaires Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Institut des Maladies Métaboliques et Casdiovasculaires Institut de Génétique et Développement de Rennes Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Université Toulouse III - Paul Sabatier Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Institut des Maladies Métaboliques et Casdiovasculaires Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Centre Hospitalier Universitaire de Bordeaux Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires

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Résumé : Abstract RATIONALE In addition to its typical rod-shape, the mammalian adult cardiomyocyte (CM) harbors a unique lateral membrane surface architecture with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) the role of which is still unknown. OBJECTIVE To investigate the development and functional role of CM crests during the postnatal period. METHODS AND RESULTS Electron/confocal microscopy and western-blot of left ventricular tissues from rat hearts indicated a late CM surface crest maturation, between postnatal day 20 (P20) and P60, as shown by substantial SSM swelling and increased claudin-5 cell surface expression. The P20-P60 postnatal stage also correlates with an ultimate maturation of the T-Tubules and the intercalated disk. At the cellular level, we identified an atypical CM hypertrophy characterized by an increase in long- and short-axes without myofibril addition and with sarcomere lateral stretching, indicative of lateral stretch-based CM hypertrophy. We confirmed the P20-P60 hypertrophy at the organ level by echocardiography but also demonstrated a transcriptomic program after P20 targeting all the cardiac cell populations. At the functional level, using Doppler echocardiography, we found that the P20-P60 period is specifically dedicated to the improvement of relaxation. Mechanistically, using CM-specific knock-out mice, we identified ephrin-B1 as a determinant of CM crest maturation after P20 controlling lateral CM stretch-hypertrophy and relaxation. Interestingly, while young adult Efnb1 CMspe−/− mice essentially show a relaxation impairment with exercise intolerance, they progressively switch toward heart failure with 100% KO mice dying after 13 months. CONCLUSIONS This study highlights a new late P20-P60 postnatal developmental stage of the heart in rodents during which the CM surface crests mature through an ephrin-B1-dependant mechanism and regulate the diastolic function. Moreover, we demonstrate for the first time that the CM crest architecture is cardioprotective.

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Fichiers liés : 2022 Karsenty e al., Crest maturation.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/03/2022
• Auteurs : Morgane Guillou LandreatAntoine DanyGaëlle Challet-BoujuEdouard-Jules LaforgueJennifer CholetJuliette LeboucherJean-Benoit HardouinPierre BodenezBertrand Le GeayIsabelle MartineauPhilippe LevassorPaul BoloJean-Yves GuilletXavier GuilleryCorine DanoCaroline Victorri-VigneauMarie Grall-Bronnec
• Organismes : methodS in Patients-centered outcomes and HEalth ResEarch Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université methodS in Patients-centered outcomes and HEalth ResEarch methodS in Patients-centered outcomes and HEalth ResEarch Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France methodS in Patients-centered outcomes and HEalth ResEarch Université de Brest Department of Prison Psychiatry [Nantes] Centre Hospitalier Universitaire d'Angers methodS in Patients-centered outcomes and HEalth ResEarch Service de Pharmacologie Clinique [CHU Nantes] methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Harm Reduction Journal le 29/10/2020

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Résumé : Abstract Background The resurgence of heroin use and the misuse of pharmaceutical opioids are some of the reasons for a worldwide increase in opioid dependence. Opioid Medication Therapies (OMT) have amply demonstrated their efficacy. From a medical point of view, the main objectives of OMT concern medical and social outcomes, centred on risk reduction and the cessation of opioid use. But patient points of view can differ and few studies have explored opioid-dependent patient viewpoints on their OMT. This variable seems important to consider in a patient-centred approach. The aim of our study was to explore points of view of people who use drugs (PWUD) treated with OMT, in a large multicentre sample. Method A cross-sectional multicentre study explored the points of view of PWUD with Opioid Use Disorder following OMT. Data regarding the patients’ points of view were collected using a self-administered questionnaire developed by the scientific committee of the study. A descriptive analysis and an exploratory factor analysis were performed to explore the structure of items exploring patient viewpoints. Results 263 opioid dependent PWUD were included, a majority were men consuming heroin prior to being prescribed OMT. 68% were on methadone, 32% were on buprenorphine. Most PWUD identified a positive impact on their lives, with 92.8% agreeing or strongly agreeing that OMT had changed a lot of things in their lives. The exploratory factor analysis identified three factors: (F1) items related to points of views concerning the objectives and efficacy of OMT; (F2) items related to the legitimacy of OMT as a treatment compared to a drug, (F3) items related to experiences and relationships with OMT. Conclusion Patient viewpoints on efficacy were correlated with the pharmacological benefits of OMT and with the associated psychosocial measures. The implications of OMT in relationships, such as the feeling of being judged, concerned a majority. Points of view were ambivalent concerning the role of OMT as a treatment or as a drug. Involving patient points of view in therapeutic strategies decisions could help enhance positive views among PWUD on OMT and help PWUD towards their recovery. Trial registration: OPAL study was registered: (NCT01847729).

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Fichiers liés : main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/03/2022
• Auteurs : Philippe ColombanBurcu Kirmizi
• Organismes : De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies Laboratoire de Dynamique Interactions et Réactivité Laboratoire de Physique de la Matière Condensée Department of Conservation and Restoration of Cultural Property, Faculty of Architecture, Yıldız Technical University, Yıldız Yerleşkesi B Blok, Beşiktaş, 34349 Istanbul, Turkey

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Résumé : Enamelling, i.e. coating of a substrate with a layer of glass by firing, is one of the most sophisticated technologies developed to decorate artefacts. China has a long expertise in the production of ceramics and glass but for technical and aesthetic reasons, 17th century (Ming Dynasty and then Kangxi reign) Chinese decors were rather similar to those obtained on paper with lavish or watercolour techniques. These productions did not permit to represent a ‘realistic’ decor, as prepared on majolica, (soft-paste)porcelain and metal wares by European craftsmen who were capable of making copies of famous paintings. Actually, much information about the ingredients and production process remain imprinted in the matter accessible by spectroscopical methods, Raman and X-ray fluorescence spectroscopy. The rareness and high value of artefacts, particularly those made at the Imperial Palace under the guidance of (Jesuit) European masters, require the use of non-invasive mobile instruments. We present here an overview of the analytical study of French (enamelled watches, Limoges wares, soft-paste porcelain, etc.) and Chinese (wucai, fengcai, falangcai, huafalang, cloisonné etc.) artefacts prepared during the 17th and first part of the 18th century (Qing Dynasty). We are able to identify the first use of European ingredients (blue As-rich cobalt, white cassiterite) and recipes (purple-red Perrot’ gold nanoparticles, Naples yellow lead pyrochlore type pigments) for the preparation of ‘realistic’ decors on Chinese ceramics and enamels, which shed light on the technological exchange between Europe and China. The results are significant in terms of comparison with the written records analyzed by historians. COLOMBAN Philippe, ZHANG Yizheng, ZHAO Bing, « Non-invasive Raman analyses of huafalang and related porcelain wares. Searching for evidence for innovative pigment technologies », Ceramics International 43(15), 2017, 12079-12088. COLOMBAN Philippe, KIRMIZI Burcu, ZHAO Bing, CLAIS Jean-Baptiste, YANG Yong, DROGUET Vincent, « Non-invasive on-site Raman study of pigments and glassy matrix of 17th-18th Century painted enamelled Chinese metal wares : Comparaison with French enamelling technology » Coatings, 10, 2020, 471. COLOMBAN Philippe, KIRMIZI Burcu, ZHAO Bing, CLAIS Jean-Baptiste, YANG Yong, DROGUET Vincent, « Investigation of the pigments and glassy matrix of painted enamelled Qing Dynasty Chinese porcelains by noninvasive on-site Raman microspectroscopy, Heritage 3(3), 2020, 915-940. COLOMBAN Philippe, KIRMIZI Burcu, GOUGEON Catherine, GIRONDA Michele, CARDINAL Catherine, « Pigments and glassy matrix of the 17th-18th century enamelled French watches: A non-invasive on-site Raman and pXRF study » Journal of Cultural Heritage 2020, 44, 1-14. COLOMBAN Philippe, KIRMIZI Burcu, SIMSEK FRANCI Gulsu, « Cobalt and Associated Impurities in Blue (and Green) Glass, Glaze and Enamel: Relationships between Raw Materials, Processing, Composition, Phases and International Trade » Minerals, 11, 2021, 633. COLOMBAN Philippe, GIRONDA Michele, VANGU Divine, KIRMIZI Burcu, ZHAO Bing, COCHET Vincent, « The technology transfer from Europe to China in the 17th-18th centuries: Non-invasive on-site XRF and Raman analyses of Chinese Qing Dynasty enameled masterpieces made using European ingredients/recipes” Materials, 2021, 14, 7434

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• Type de publi. : Article dans une revue
• Date de publi. : 25/03/2022
• Auteurs : Jean PersonnazEnzo PiccoloAlizée DortignacJason IacovoniJérôme J. MarietteVincent RocherArnaud PolizziAurélie BatutSimon DeleruyelleLucas BourdensOcéane DelosLucie Combes-SoiaRomain PaccoudElsa MoreauFrédéric MartinsThomas ClouaireFadila BenhamedAlexandra MontagnerWalter WahliRobert F. SchwabeArmelle YartIsabelle Castan-LaurellJustine Bertrand-MichelOdile Burlet-SchiltzCatherine PosticPierre-Damien DenechaudCédric MoroGaëlle LegubeChih-Hao LeeHervé GuillouPhilippe P. ValetCedric DrayJean-Philippe Pradère
• Organismes : Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Unité de Mathématiques et Informatique Appliquées de Toulouse SIAAP - Direction du Développement et de la Prospective Toxicologie Intégrative & Métabolisme Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut de pharmacologie et de biologie structurale Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Plateforme Génome & Transcriptome Unité de biologie Moléculaire, Cellulaire et du Développement Institut Cochin Institut des Maladies Métaboliques et Casdiovasculaires Unité de biologie Moléculaire, Cellulaire et du Développement Center for Integrative Genomics - Institute of Bioinformatics, Génopode Lee Kong Chian School of Medicine [Nanyang Technological University] Columbia University [New York] Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut de pharmacologie et de biologie structurale Institut Cochin Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Unité de biologie Moléculaire, Cellulaire et du Développement Harvard T.H. Chan School of Public Health Toxicologie Intégrative & Métabolisme Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires
• Publié dans Science Advances le 21/10/2020

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Résumé : Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very complex and fine-tuned by chromatin dynamics and multiple key transcription factors. Here, we demonstrate that the nuclear factor HMGB1 acts as a strong repressor of liver lipogenesis. Mice with liver-specific Hmgb1 deficiency display exacerbated liver steatosis, while Hmgb1 -overexpressing mice exhibited a protection from fatty liver progression when subjected to nutritional stress. Global transcriptome and functional analysis revealed that the deletion of Hmgb1 gene enhances LXRα and PPARγ activity. HMGB1 repression is not mediated through nucleosome landscape reorganization but rather via a preferential DNA occupation in a region carrying genes regulated by LXRα and PPARγ. Together, these findings suggest that hepatocellular HMGB1 protects from liver steatosis development. HMGB1 may constitute a new attractive option to therapeutically target the LXRα-PPARγ axis during NAFLD.

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Fichiers liés : sciadv.abg9055.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/03/2022
• Auteurs : Annie OuinÉmilie AndrieuGerard BalentRomain CarriéJean-Philippe ChoisisJean-François DejouxJean-Pierre del CorsoJames DesaegherMathieu FauvelNicola GallaiSylvie LadetJustine Rivers-MooreZafarani UwingabireDavid SheerenAude VialatteBarbara Cichosz
• Organismes : Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Centre for Environmental and Climate Research [Lund] Dynamiques et écologie des paysages agriforestiers Systèmes d'élevage méditerranéens et tropicaux Centre d'études spatiales de la biosphère Laboratoire d'Etude et de Recherche sur l'Economie, les Politiques et les Systèmes Sociaux Dynamiques et écologie des paysages agriforestiers Centre d'études spatiales de la biosphère Laboratoire d'Etude et de Recherche sur l'Economie, les Politiques et les Systèmes Sociaux Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Laboratoire d'Etude et de Recherche sur l'Economie, les Politiques et les Systèmes Sociaux Dynamiques et écologie des paysages agriforestiers Dynamiques et écologie des paysages agriforestiers Chambre Régionale d'Agriculture d'Occitanie
• Publié dans Innovations Agronomiques le 24/10/2020

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Résumé : Le projet PSDR4 Sebioref avait pour objectif de qualifier le service écosystémique de pollinisation rendu par la biodiversité, et d’identifier les leviers paysagers pour améliorer ce service de pollinisation. In fine, l’objectif était d’envisager des coordinations entre producteurs et utilisateurs potentiels de services écosystémiques à l’échelle des territoires. Il a été mené par trois laboratoires (Dynafor, Cesbio, Lereps) et co-animé avec la Chambre Régionale d’Agriculture d’Occitanie. Le projet Sebioref a fourni des outils en télédétection pour l’identification des ressources florales dans les prairies sur de larges étendues, la modélisation spatialisée du processus de pollinisation et de concertation entre les acteurs. Nous avons montré que le service écosystémique de pollinisation, notamment vis à vis des cultures entomophiles, nécessitait une approche paysagère pour permettre la complémentarité entre les ressources florales présentes dans les haies, lisières de bois et prairies. Ainsi, la transition agro-écologique devra intégrer les échelles paysagères et territoriales. Nous avons aussi montré que les acteurs du territoire étudié sont très concernés par la protection des espèces d’abeilles sauvages et sont sources de propositions pour favoriser cette diversité et les services qu’elle rend. L’action collective semble donc être la plus à même de répondre aux attentes des acteurs dans la gestion d’un paysage qui produit et offre une multitude de services.

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Fichiers liés : 2022-OUIN-12_IA_Vol86.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/03/2022
• Auteurs : Mathieu LesouhaitierMurielle GregoireArnaud GacouinValentin CoirierAurelien FrerouCaroline PiauVincent CattoirErwan DumontetMatthieu RevestPierre TattevinAntoine RoisneJean-Philippe VerhoyeErwan FlecherYves Le TulzoKarin TarteJean-Marc Tadie
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment, Cell Differentiation, Immunology and Cancer
• Publié dans Journal of Leukocyte Biology le 26/10/2020

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Résumé : Staphylococcus aureus is the main bacterial pathogen encountered in mediastinitis after cardiac surgical procedures; it remains a devastating complication with a high mortality rate. As neutrophils have a primordial role in the defense against staphylococcus infection and cardiopulmonary bypass (CPB) is known to induce immunosuppression, the aim of this study was to investigate CPB impact on neutrophil functions. Patients without known immunosuppression scheduled for cardiac surgery with CPB were included. Bone marrow and blood samples were harvested before, during, and after surgery. Neutrophil phenotypic maturation and functions (migration, adhesion, neutrophil extracellular trap [NET] release, reactive oxygen species (ROS) production, phagocytosis, and bacteria killing) were investigated. Two types of Staphylococcus aureus strains (one from asymptomatic nasal carriage and another from mediastinitis infected tissues) were used to assess in vitro bacterial direct impact on neutrophils. We found that CPB induced a systemic inflammation with an increase in circulating mature neutrophils after surgery. Bone marrow sample analysis did not reveal any modification of neutrophil maturation during CPB. Neutrophil lifespan was significantly increased and functions such as NET release and ROS production were enhanced after CPB whereas bacteria killing and phagocytosis were not impacted. Results were similar with the two different isolates of Staphylococcus aureus. These data suggest that CPB induces a recruitment of mature neutrophils via a demargination process rather than impacting their maturation in the bone marrow. In addition, neutrophils are fully efficient after CPB and do not contribute to postoperative immunosuppression.

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Fichiers liés : Lesouhaitier et al - 2021 - Neutrophil function and bactericidal activity against Staphylococcus aureus.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 24/03/2022
• Auteurs : Christophe Le TerrierFlorian SigaudSaid LebbahLuc DesmedtDavid HajageClaude GuérinJérôme PuginSteve PrimmazNicolas TerziAlain MercatPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PreauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DésertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonniereDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérôme PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSebastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultElie AzoulayMichael DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGael PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Service de Réanimation Médicale [Grenoble] Centre de pharmacoépidémiologie AP-HP Service d'anesthésie et réanimation chirurgicale [Nantes] Centre de pharmacoépidémiologie AP-HP Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Centre Hospitalier Universitaire [CHU Grenoble] Hypoxie et PhysioPathologie Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Université d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire d'Angers Fédération de Médecine Translationnelle de Strasbourg Nanomédecine Régénérative Centre de recherche en épidémiologie et santé des populations Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Université Paris-Saclay Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique Service de Soins Intensifs [CHU Caen] Centre d’Investigation Clinique [Tours] CIC 1415 CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Cochin [AP-HP] Service de réanimation médicale polyvalente [CHU Cochin] Hôpital Ambroise Paré [AP-HP] Hôpital l'Archet Unité de Recherche Clinique Côte d’Azur CIC Cochin Pasteur Centre de Recherche Saint-Antoine CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] Centre Hospitalier Régional Universitaire de Brest Médecine Intensive Réanimation [CHRU Brest] Laboratoire de Traitement de l'Information Medicale Laboratoire de Traitement de l'Information Medicale Médecine Intensive Réanimation [CHRU Brest] Centre Hospitalier de Cholet Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Equipe LIPNESS (LNC - U1231) Service de Réanimation Médicale (CHU de Dijon) Service de Réanimation Médicale (CHU de Dijon) Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 TRANSCOV-study group Hôpital de la Conception [CHU - APHM] Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Nord [CHU - APHM] Aix-Marseille Université - École de médecine Centre hospitalier Marc Jacquet (Melun) Service de Médecine intensive [CH de Melun] Hopital d'instruction des armées Sainte-Anne [Toulon] Hopital d'instruction des Armées Villenave d'Ornon Hôpital d'instruction des Armées Percy Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hopital Saint-Louis [AP-HP] Hôpital l'Archet Centre Hospitalier Universitaire de Nice Unité de Recherche Clinique Côte d’Azur Université Côte d'Azur - Faculté de Médecine Centre Hospitalier Universitaire de Nice Hôpital La Source [Orléans] Centre Hospitalier Regional d'Orléans Biologie Intégrée du Globule Rouge Université des Antilles (Pôle Guadeloupe) CHU Pointe-à-Pitre / Abymes [Guadeloupe] [GIN] Grenoble Institut des Neurosciences Université Grenoble Alpes [GIN] Grenoble Institut des Neurosciences
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19. Methods: All intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgium and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score. Results: Among 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay and 491 (23%) during the first 24 h following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO2/FiO2 ratio > 150 mmHg when prone positioning was initiated. Among non-early PP group patients, 1013 (47.4%) patients had finally been placed in PP within a median delay of 3 days after ICU admission. Day-60 mortality in non-early PP group was 34.2% versus 39.3% in the early PP group (p = 0.038). Day-28 and Day-90 mortality as well as the need for adjunctive therapies was more important in patients with early PP. After propensity score adjustment, no significant difference in survival at Day-60 was found between the two study groups (HR 1.34 [0.96-1.68], p = 0.09 and HR 1.19 [0.998-1.412], p = 0.053 in complete case analysis or in multiple imputation analysis, respectively). Conclusions: In a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, our data failed to show a survival benefit associated with early PP started within 24 h after ICU admission compared to PP after day-1 for all COVID-19 patients requiring invasive mechanical ventilation regardless of their severity.

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Fichiers liés : Le Terrier_2022.pdf

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