Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2022
• Auteurs : Andy KarabajakianThibaut GarrivierCarole CrozesNicolas GadotJean-Yves BlayFrédéric BérardPhilippe CérusePhilippe ZrounbaPierre SaintignyCharles MastierJérôme Fayette
• Organismes : Hospices Civils de Lyon Immunité de l’épiderme & allergie - Epidermal Immunity and Allergy [CIRI]
• Publié dans Oncotarget le 22/10/2020

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Résumé : Abstract Introduction/Background Manifestations of psoriasis in special areas are difficult to treat and are associated with a high disease burden and significant quality of life (QoL) impairment. Topical therapies may be inadequate for these patients, necessitating systemic treatment. Objective The objective of EMBRACE was to evaluate the impact on QoL, efficacy and safety of apremilast 30 mg BID in patients with limited skin involvement with plaque psoriasis manifestations in special areas and impaired QoL. Methods EMBRACE (NCT03774875) was a phase 4, randomized, placebo‐controlled, multinational study. Patients had plaque psoriasis not controlled by topical therapy; lack of response, contraindication or intolerance to conventional first‐line systemic therapy; psoriasis in ≥1 special area (including visible locations, scalp, nails, genital areas or palmoplantar areas); Psoriasis Area and Severity Index (PASI) ≥3 to ≤10; and Dermatology Life Quality Index (DLQI) >10. The primary endpoint was DLQI response (≥4‐point reduction) at Week 16. Results Of 277 randomized patients (apremilast: n = 185; placebo: n = 92), 221 completed Week 16 (apremilast: n = 152; placebo: n = 69). The primary endpoint (≥4‐point reduction in DLQI at Week 16) was met by significantly more patients receiving apremilast (73.3%) versus placebo (41.3%; p < 0.0001). Significantly greater improvement in affected body surface area (BSA) and PASI was observed with apremilast versus placebo at Week 16. There were also significantly greater improvements with apremilast versus placebo in itch numeric rating scale (−2.5 vs. −0.9, p < 0.0001) and skin discomfort/pain visual analog scale (−21.5 vs. −5.4, p = 0.0003) and greater achievement of Patient Benefit Index ≥1 (77% vs. 40%, p < 0.0001) at Week 16. No new safety signals were observed. Conclusions Apremilast significantly improved skin‐related QoL in patients with limited skin involvement with plaque psoriasis in special areas and highly impaired QoL. The safety profile was consistent with prior apremilast studies.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/12/2022
• Auteurs : Marie LabatJ P Couperus CabadağAmin GhaithArie IrmanAnthony BerliouxPhilippe BerteaudFrédéric BlacheStefan BockFrançois BouvetFabien BriquezYen-Yu ChangSébastien CordeAlexander DebusCarlos de OliveiraJean-Pierre DuvalYannick DietrichMoussa El AjjouriChristoph EisenmannJulien GautierRené GebhardtSimon GramsUwe HelbigChristian HerbeauxNicolas HubertCharles KitegiOlena KononenkoMichael KuntzschMaxwell LabergeStéphane LêBruno LeluanAlexandre LoulergueVictor MalkaFabrice MarteauManh Huy N. GuyenDriss Oumbarek-EspinosRichard PauschDamien PereiraThomas PüschelJean-Paul RicaudPatrick RommeluereEléonore RousselPascal RousseauSusanne SchöbelMourad SebdaouiKlaus SteinigerKeihan TavakoliCedric ThauryPatrick UferMathieu ValléauMarc VandenbergheJosé VétéranUlrich SchrammMarie-Emmanuelle Couprie
• Organismes : Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf University of Texas at Austin [Austin] Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire d'Optique Appliquée Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL
• Publié dans Nature Photonics le 01/11/2020

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Résumé : Abstract Free-electron lasers generate high-brilliance coherent radiation at wavelengths spanning from the infrared to the X-ray domains. The recent development of short-wavelength seeded free-electron lasers now allows for unprecedented levels of control on longitudinal coherence, opening new scientific avenues such as ultra-fast dynamics on complex systems and X-ray nonlinear optics. Although those devices rely on state-of-the-art large-scale accelerators, advancements on laser-plasma accelerators, which harness gigavolt-per-centimetre accelerating fields, showcase a promising technology as compact drivers for free-electron lasers. Using such footprint-reduced accelerators, exponential amplification of a shot-noise type of radiation in a self-amplified spontaneous emission configuration was recently achieved. However, employing this compact approach for the delivery of temporally coherent pulses in a controlled manner has remained a major challenge. Here we present the experimental demonstration of a laser-plasma accelerator-driven free-electron laser in a seeded configuration, where control over the radiation wavelength is accomplished. Furthermore, the appearance of interference fringes, resulting from the interaction between the phase-locked emitted radiation and the seed, confirms longitudinal coherence. Building on our scientific achievements, we anticipate a navigable pathway to extreme-ultraviolet wavelengths, paving the way towards smaller-scale free-electron lasers, unique tools for a multitude of applications in industry, laboratories and universities.

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Fichiers liés : Seeded_free-electron_laser_driven_by_a_compact_las.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/12/2022
• Auteurs : Philippe Ragel
• Organismes : Patrimoine, Littérature, Histoire

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Résumé : Ce texte propose de revenir sur les quatre adaptations cinématographiques du roman de James M. Cain "Le facteur sonne toujours deux fois" ("The Postman Always Rings Twice", 1934), et plus particulièrement sur la figure de son héroïne Cora. De Pierre Chenal en 1939 à Tay Garnett en 1946, de Luchino Visconti en 1943 à Bob Rafelson en 1981, il s’agit de dessiner ici les traits du multiple visage de "ténébreuse" qu'y incarne Cora, personnage plus complexe qu’il n’y paraît et où joue pour beaucoup le contexte historique de production qui, à chacune des époques considérées, l’a engendré.

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Fichiers liés : Philippe Ragel. PLH. Cora à l’épreuve de l’écran..pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/12/2022
• Auteurs : Marie-Christine Steckel-AssouèreDamien AugiasGaëtan BaillyYann BivaudMichèle Boubay-PagèsCarole Chevilley-HiverDenis CrampePierre CreuzetNathalie DevezeHugo DevillersJérôme DuboisJacques Fialaire Didier GuignardPhilippe HammanKatarzyn KmonkAdèle de MesnardConstant Papillon-AmblardRomain PasquierFrançois RangeonChristophe SardotMarie-Christine Steckel-AssouereAntoine Teitgen
• Organismes : Université de Limoges Communauté d'universités et établissements de Toulouse Université de Pau et des Pays de l'Adour Institut d'Administration des Entreprises - Pau Observatoire des Mutations Institutionnelles et Juridiques Sociétés, Acteurs, Gouvernement en Europe Université Jean Moulin - Lyon 3 Environnement, Ville, Société Institut de Droit de l'Environnement Préfecture des Hautes-Pyrénées Institut du Droit de l'Espace, des Territoires, de la Culture et de la Communication Université Marie et Louis Pasteur Centre de Recherches Juridiques de l'Université de Franche-Comté - UFC (UR 3225) COMMUNE De TARBES Centre ville en mouvement Centre universitaire de recherches sur l'action publique et le politique. Epistémologie et Sciences sociales - UMR CNRS UPJV 7319 Université Paris 13 Institut de droit public, sciences politiques et sociales STMicroelectronics [Crolles] Sociétés, Acteurs, Gouvernement en Europe Institut de Droit de l'Environnement Centre ville en mouvement Arènes: politique, santé publique, environnement, médias Centre universitaire de recherches sur l'action publique et le politique. Epistémologie et Sciences sociales - UMR CNRS UPJV 7319 Notaire Université de Limoges Communauté d'universités et établissements de Toulouse Université de Pau et des Pays de l'Adour Institut d'Administration des Entreprises - Pau Observatoire des Mutations Institutionnelles et Juridiques Notaire

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Résumé : Les 21 auteurs (universitaires et praticiens) livrent leurs réflexions et des propositions concrètes sur le rôle du maire, les atouts des centres des villes moyennes, les solutions et idées pour la relance et l’attractivité des centres villes, la lutte contre les nuisances urbaines (et les friches commerciales, la gouvernance urbaine transfrontalière, la politique de la ville, l’Agence nationale de la cohésion des territoires, les conventions action cœur de ville et les opérations de revitalisation du territoire (comparaison Dax, Mont-de-Marsan, Lourdes/Tarbes et Pau), le dispositif « Petites villes de demain », les enjeux en Seine-Saint-Denis, l’urbanisme tactique, l’enjeu du sport en ville, le verdissement des villes et l’évolution des villes étendues.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/12/2022
• Auteurs : Philippe FosseJean-Baptiste FourvelNicolas FrerebeauCarole FritzMietje GermonpréStéphane MadelaineGilles ToselloJean-Philip Brugal
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Archéosciences Bordeaux Laboratoire d'Archéologie Moléculaire et Structurale Centre de recherche et d’études de l’art préhistorique Centre de recherche et d’études de l’art préhistorique Laboratoire méditerranéen de préhistoire Europe-Afrique

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Résumé : Los lobos (Canis lupus) aparecieron en Europa a finales de la primera mitad del Pleistoceno medio. Estos depredadores eran carnívoros resistentes y jerarquizados que competían con otras especies sociales que compartían una dieta similar: las hienas manchadas fósiles (Crocuta ssp.) y los humanos (Homo ssp.). El impacto del lobo en la formación/modificación de los conjuntos óseos del Pleistoceno es todavía difícil de caracterizar. En el sur de Francia, la especie es común a partir del MIS 8-7 y algunos yacimientos, principalmente kársticos, permiten abordar su paleoecología. Basándose en datos eco-etológicos y neotafonómicos, pero también en yacimientos pleistocenos recientemente estudiados, esta contribución propone una reflexión sobre los criterios que permiten describir a los lobos como ocupantes de cavidades (co-ocurrencia con otras especies identificadas, NISP y NMI de carnívoros y ungulados, consumo de huesos), en comparación con las principales especies osteófagas. Además, se elabora un inventario de las modificaciones antropogénicas, tanto dietéticas (marcas de corte) como simbólicas (arte parietal, arte mueble, ornamentos). Este estudio destaca que los lobos ocupan principalmente cuevas poco profundas, acumulando (?) o carroñeando huesos de ungulados de tamaño medio (cérvidos, cápridos). El consumo se centra en las extremidades de los huesos cortos (costillas, apófisis vertebrales) y en los huesos largos (epífisis) asociados a la presencia de huesos (moderadamente) digeridos.

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Fichiers liés : FOSSE_ET_AL_2024_LUPUS.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Michel AziziFelix MahfoudMichael A WeberAndrew S P SharpRoland E SchmiederPhilipp LurzMelvin D LoboNaomi D L FisherJoost DaemenMichael J BlochJan BasileKintur SanghviManish SaxenaPhilippe GosseJ. Stephen JenkinsTerry LevyAlexandre PersuBenjamin KablyLisa ClaudeHelen Reeve-StofferCandace McclureAjay J KirtaneChristopher MullinLisa ThackerayGlenn ChertowThomas KahanHarold DauermanSteven UlleryJ. Dawn AbbottAndreas LoeningRon ZagoriaJohn CostelloCourtney KrathanLuot LewisAndrew McelvarrJohn ReillyMichael CashShannon WilliamsMaria JarvisPete FongCheryl LafferJames GainerMark RobbinsSherron CrookSarita MaddelDavid HsiScott MartinEdward PortnayMaryanne DuceySuzanne RoseElizabeth DelmastroSripal BangaloreStephen WilliamsStanley CabosCarolina Rodriguez AlvarezThomas TodoranEric PowersEmily HodskinsVijay PaladuguAnna TecklenburgChandan DevireddyJanice LeaBryan WellsAmanda FiebachClaudia MerlinFlorian RaderSuhail DohadHyun-Min KimMohammad RashidJosephine AbrahamTheophilus OwanAnu AbrahamIran LavasaniHailey NeilsonDavid CalhounThomas McelderryWilliam MaddoxSuzanne OparilSheila KinderJai RadhakrishnanCandido BatresSuzanne EdwardsJoseph GarasicDoug DrachmanRandy ZusmanKenneth RosenfieldDanny DoMatheen KhuddusSuzanne ZentkoJames O'MearaIlie BarbAbby FosterAlice BoyetteYale WangDesmond JayNedaa SkeikRobert SchwartzRose PetersonJo Anne GoldmanJessie GoldmanGary LedleyNancy KatofSrinivasa PotluriScott BiedermannJacquelyn WardMegan WhiteLaura MauriPiotr SobieszczkyAlex SmithLaura AseltineRick StoufferAlan HinderliterEric PauleyTyrone WadeDavid ZidarMehdi ShishehborBarry EffronMarco CostaTerence SemenecChanwit RoongsritongPriscilla NelsonBridget NeumannDebbie CohenJay GiriRobin NeubauerThu VoAtul R ChughPei-Hsiu HuangPowell JoseJohn FlackRobert FishmanMichael JonesTodd AdamsChristopher BajzerAnthony MathurAjay JainArmida BalawonOlivier ZongoClare BentDavid BeckettNicki LakemanSarah KennardRichard J D’souzaSarah StattonLindsay WilkesChristine AnningJeremy SayerSudha Ganesh IyerNicholas RobinsonAnnaliza SevillanoMadelaine OcampoRobert GerberMohamad FarisAndrew John MarshallJanet SinclairHayley PepperJustin DaviesNeil ChapmanPaula BurakPaula CarvelliSachin JadhavJane QuinnLars Christian RumpJohannes StegbauerLars SchimmöllerSebastian PotthoffClaudia SchmidSylvia RoederJoachim WeilLukas HaferTolga AgdirliogluTanja KöllnerMichael BöhmSebastian EwenSaarraaken KulenthiranAngelika WachterChristina KochKarl FenglerKarl-Philipp RommelKai TrautmannMartin PetzoldChristian OttAxel SchmidMichael UderUlrike HeinritzKerstin Fröhlich-EndresSabine Genth-ZotzDenise KämpfnerArmin GraweJohannes HöhneBärbel KaesbergerConstantin von Zur MühlenDennis WolfMarkus WelzelGudrun HeinrichsBarbara TrabitzschAntoine CrémerHervé TrillaudPanteleimon PapadopoulosFlorent MaireJulie GaudissardMarc SapovalMarine LivrozetAurélien LorthioirLaurence AmarValérie PaquetAtul PathakBenjamin HontonMarianne CottinFrédéric PetitPierre LantelmeConstance BergePierre-Yves CourandFatou LangevinPascal DelsartBenjamin LongereGuillaume LedieuFrançois PontanaCoralie SommevilleFabien BertrandLida FeyzVictor ZeijenArno RuiterElisabeth HuyskenPeter BlankestijnMichiel VoskuilZwaantina RittersmaHelma DolmansA.A. KroonW.H. van ZwamJeannique VrankenClaudia de Haan.Jean RenkinFrédéric MaesChristophe BeauloyeJean-Philippe LengeléDominique HuyberechtsAnne BouvieAdam WitkowskiAndrzej JanuszewiczJacek KądzielaAleksander PrejbisjDagmara HeringDariusz CiecwierzMilosz J JaguszewskiRadoslaw Owczuk
• Organismes : CIC - HEGP AP-HP - Hôpital Européen Georges Pompidou CArdiovasculaire Rénal Transplantation nEurovasculaire [Paris] Universität des Saarlandes [Saarbrücken] = Saarland University [Saarbrücken] SUNY Downstate Medical Center University Hospital of Wales University of Exeter Universitätsklinikum Erlangen [Erlangen] Universität Leipzig = Leipzig University Queen Mary University of London Brigham & Women’s Hospital [Boston] Erasmus University Medical Center [Rotterdam] University of Nevada [Reno] Medical University of South Carolina [Charleston] Queen Mary University of London Hôpital Saint-André [Bordeaux] Royal Bournemouth Hospital Université Catholique de Louvain = Catholic University of Louvain Cliniques Universitaires Saint-Luc [Bruxelles] AP-HP - Hôpital Européen Georges Pompidou ReCor Medical Inc Columbia University Medical Center Danderyds sjukhus = Danderyd University Hospital University of Vermont [Burlington] Stanford University Argolyn Bioscience, Inc.
• Publié dans JAMA Cardiology le 25/10/2020

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Résumé : Importance Although early trials of endovascular renal denervation (RDN) for patients with resistant hypertension (RHTN) reported inconsistent results, ultrasound RDN (uRDN) was found to decrease blood pressure (BP) vs sham at 2 months in patients with RHTN taking stable background medications in the Study of the ReCor Medical Paradise System in Clinical Hypertension (RADIANCE-HTN TRIO) trial. Objectives To report the prespecified analysis of the persistence of the BP effects and safety of uRDN vs sham at 6 months in conjunction with escalating antihypertensive medications. Design, Setting, and Participants This randomized, sham-controlled, clinical trial with outcome assessors and patients blinded to treatment assignment, enrolled patients from March 11, 2016, to March 13, 2020. This was an international, multicenter study conducted in the US and Europe. Participants with daytime ambulatory BP of 135/85 mm Hg or higher after 4 weeks of single-pill triple-combination treatment (angiotensin-receptor blocker, calcium channel blocker, and thiazide diuretic) with estimated glomerular filtration rate (eGFR) of 40 mL/min/1.73 m 2 or greater were randomly assigned to uRDN or sham with medications unchanged through 2 months. From 2 to 5 months, if monthly home BP was 135/85 mm Hg or higher, standardized stepped-care antihypertensive treatment starting with aldosterone antagonists was initiated under blinding to treatment assignment. Interventions uRDN vs sham procedure in conjunction with added medications to target BP control. Main Outcomes and Measures Six-month change in medications, change in daytime ambulatory systolic BP, change in home systolic BP adjusted for baseline BP and medications, and safety. Results A total of 65 of 69 participants in the uRDN group and 64 of 67 participants in the sham group (mean [SD] age, 52.4 [8.3] years; 104 male [80.6%]) with a mean (SD) eGFR of 81.5 (22.8) mL/min/1.73 m 2 had 6-month daytime ambulatory BP measurements. Fewer medications were added in the uRDN group (mean [SD], 0.7 [1.0] medications) vs sham (mean [SD], 1.1 [1.1] medications; P = .045) and fewer patients in the uRDN group received aldosterone antagonists at 6 months (26 of 65 [40.0%] vs 39 of 64 [60.9%]; P = .02). Despite less intensive standardized stepped-care antihypertensive treatment, mean (SD) daytime ambulatory BP at 6 months was 138.3 (15.1) mm Hg with uRDN vs 139.0 (14.3) mm Hg with sham (additional decreases of −2.4 [16.6] vs −7.0 [16.7] mm Hg from month 2, respectively), whereas home SBP was lowered to a greater extent with uRDN by 4.3 mm Hg (95% CI, 0.5-8.1 mm Hg; P = .03) in a mixed model adjusting for baseline and number of medications. Adverse events were infrequent and similar between groups. Conclusions and Relevance In this study, in patients with RHTN initially randomly assigned to uRDN or a sham procedure and who had persistent elevation of BP at 2 months after the procedure, standardized stepped-care antihypertensive treatment escalation resulted in similar BP reduction in both groups at 6 months, with fewer additional medications required in the uRDN group. Trial Registration ClinicalTrials.gov Identifier: NCT02649426

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Fichiers liés : 2022-Azizi-JAMA cardiology.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Béninwendé Leticia Delphine SakanaAnaïs MennecierPaulin FaoSouleymane TassembedoJean-Pierre MolesDramane KaniaAjani Ousmane TaofikiFranck Edgar KadebaIbrahima DialloSabrina Eymard-DuvernayMorgana D’ottaviNicolas MedaBeatriz MosqueiraPhilippe Van de PerreNicolas Nagot
• Organismes : Centre Muraz [Bobo-Dioulasso, Burkina Faso] Pathogenesis and Control of Chronic and Emerging Infections Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Pathogenesis and Control of Chronic and Emerging Infections Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Inserm Occitanie Méditerranée (Montpellier) Pathogenesis and Control of Chronic and Emerging Infections Institut National de Santé Publique du Burkina Faso - National Institute of Public Health [Ouagadougou] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Bulletin of the World Health Organization le 22/10/2020

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Résumé : Objective: to evaluate the performance of the cascade of activities for prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) at the second immunization visit in Burkina Faso. Methods: in a cross-sectional study, we recruited mothers attending the second immunization visit for their infant in 20 health centres of Bobo-Dioulasso city, Burkina Faso over 12 months (2019–2020). We administered a short questionnaire to 14 176 mothers and performed HIV serological tests on mothers who had not been tested in the last 3 months. All mothers were asked about their attendance for antenatal care and HIV rapid testing. HIV-infected mothers were also asked about the timing of their HIV diagnosis, antiretroviral therapy, pre-exposure prophylaxis initiation at birth and infant diagnosis of HIV. Findings: of 14 136 respondents, 13 738 (97.2%) had at least one HIV serological test in their lifetime. Of 13 078 mothers who were never tested or were HIV-negative, 12 454 (95.2%) were tested during or after their last pregnancy. Among HIV-infected mothers already aware of their status, 110/111 (99.1%) women were on antiretroviral therapy. Among HIV-exposed infants, 84/101 (83.2%) babies received 6 weeks of antiretroviral prophylaxis at birth and 58/110 (52.7%) had a blood sample collected for early infant diagnosis. Only two mothers received their child’s test results at the time of the second immunization visit. Four mothers were newly diagnosed as HIV-positive during the study. Conclusion: collecting data at the second immunization visit, a visit rarely missed by mothers, could be useful for identifying gaps in the PMTCT cascade in settings where mothers are difficult to reach, such as in low-income countries with intermediate or low HIV prevalence.

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Fichiers liés : BLT.22.288522.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Magali ColombatMargot GaspardMylène CamusJessica Dalloux-ChioccioliAudrey DelasElsa PoullotAnissa MoktefiArnaud FrançoisAnne MoreauJean-Bapiste GibierPierre RaynaudAntoine HuartAlexis PiedrafitaJulia GilhodesOlivier LairezGilles GrateauSophie Georgin-LavialleHervé MaisonneuvePhilippe MoreauArnaud JaccardFranck BridouxViolaine Plante-BordeneuveThibaud DamyHervé MalPierre BroussetSophie ValleixOdile Burlet-Schiltz
• Organismes : Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Institut de pharmacologie et de biologie structurale Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole AP-HP - Hôpital Henri-Mondor AP-HP - Hôpital Henri-Mondor Institut Mondor de Recherche Biomédicale Service d'Anatomie et Cytologie Pathologique [CHU Rouen] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut de Pathologie [CHU Lille] Centre Hospitalier Saint Jean de Perpignan Département de Néphrologie et Transplantation d'organes [CHU Toulouse] Département de Néphrologie et Transplantation d'organes [CHU Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires Oncopole Claudius Regaud Service Cardiologie [CHU Toulouse] Groupe de recherche clinique Amylose AA Sorbonne Université Groupe de recherche clinique Amylose AA Sorbonne Université AP-HP - Hôpital Tenon Groupe de recherche clinique Amylose AA Sorbonne Université Groupe de recherche clinique Amylose AA Sorbonne Université AP-HP - Hôpital Tenon Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Limoges Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Institut Mondor de Recherche Biomédicale Département de neurosciences AP-HP - Hôpital Henri-Mondor AP-HP - Hôpital Bichat - Claude Bernard [Paris] Institut Universitaire du Cancer de Toulouse - Oncopole AP-HP - Hôpital Cochin-Broca-Hôtel Dieu [Paris] Centre de Recherche des Cordeliers Institut de pharmacologie et de biologie structurale
• Publié dans Haematologica le 30/10/2020

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Fichiers liés : 1072983.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Salomé FournierThierry SardinPhilippe DreyfusDidier FrançoisXavier MandretMarion SimeoniJean-Pierre RenaudEmila AkroumeAlain BouvetAlain BerthelotHolger WernsdörferMiguel RiviereJulien Sainte-MarieSandrine Brèteau-AmoresFrançois de ColignyChristine Deleuze
• Organismes : Recherche, développement et innovation Office National des Forêts Recherche, développement et innovation Recherche, développement et innovation Office National des Forêts Office National des Forêts Recherche, développement et innovation Recherche, développement et innovation Institut Technologique Forêt Cellulose Bois-construction Ameublement Institut Technologique Forêt Cellulose Bois-construction Ameublement SILVA Bureau d'Économie Théorique et Appliquée SILVA Bureau d'Économie Théorique et Appliquée Botanique et Modélisation de l'Architecture des Plantes et des Végétations Office National des Forêts
• Publié dans Annals of Forest Science le 26/10/2020

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Résumé : We provide a database of 52 silvicultural scenarios recommended in French public forests including relevant dendrometric variables and metrics for carbon accounting. The dataset is available at https://doi.org/10.57745/QARRFS . Associated metadata are available at https://metadata-afs.nancy.inra.fr/geonetwork/srv/fre/catalog.search#/metadata/f76ed27f-325d-493b-8731-0995dcaa7805 . Special attention was paid to offer carbon metrics required for the French Label Bas Carbone offset projects.

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Fichiers liés : s13595-022-01171-7-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luis Felipe ReyesSrinivas MurthyEsteban Garcia-GalloLaura MersonElsa Ibáñez-PradaJordi RelloYuli FuentesIgnacio Martin-LoechesFernando BozzaSara DuqueFabio Silvio TacconeRobert FowlerChristiana KartsonakiBronner GonçalvesBarbara Wanjiru CitarellaDiptesh AryalErlina BurhanMatthew CummingsChristelle DelmasRodrigo DiazClaudia Figueiredo-MelloMadiha HashmiPrasan Kumar PandaMiguel Pedrera JiménezDiego Fernando Bautista RinconDavid ThomsonAlistair NicholJohn MarshallPiero OlliaroAli AbbasSheryl Ann AbdukahilRyuzo AbeLaurent AbelLara AbsilSubhash AcharyaAndrew AckerDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimRazi AlalqamTala Al-DabbousSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliNaseem Ali ShahKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesJoana Alves CabritaMaria AmaralPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalAngel AsensioNamra AsifMohammad AsimJean Baptiste AssieAnika AtiqueA. AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrNadia BaigJ. Kenneth BaillieErica BakAgamemnon BakakosAndriy BalValeria BalanFirouzé Bani-SadrRenata BarbalhoWendy BarclayMichaela BarnikelHelena BarrasaAudrey BarreletCleide BarrigotoMarie BartoliJoaquín BaruchRomain BasmaciDenise BattagliniJules BauerDenisse Bazan DowAbigail BeaneAlexandra BedossaHusna BegumSylvie BehilillAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameMarine BeluzeNicolas BenechDehbia BenkerrouSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginJosé Luis Bernal SobrinoGiulia BertoliLorenzo BertolinoSimon BessisSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarClaudia BiancoMoirangthem Bikram SinghFelwa Bin HumaidFrançois BissuelLaurent BitkerJonathan BittonPablo Blanco-SchweizerCatherine BlierFrank BloosMathieu BlotFilomena BocciaLaetitia BodenesDebby BogaertAnne-Hélène BoivinPierre-Adrien BolzeFrançois BompartDiogo BorgesRaphaël BorieHans Martin BosseElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDounia BouhmaniDamien BouhourKevin BouillerLaurence BouilletCamile BouisseAnne-Sophie BoureauJohn BourkeMaude BouscambertAurore BousquetJason BouziotisBianca BoxmaMarielle Boyer-BesseyreMaria BoylanAxelle BraconnierCynthia BragaTimo BrandenburgerFilipa Brás MonteiroLuca BrazziDorothy BreenPatrick BreenKathy BrickellAlex BrowneShaunagh BrowneMarjolein Brusse-KeizerNina BuchteleChristian BuesaquilloPolina BugaevaMarielle BuissonAidan BurrellIngrid BustosDenis ButnaruAndré CabieSusana CabralEder CaceresCyril CadozRui Caetano GarcêsKate CalligyJose Andres CalvacheJoão CamõesValentine CampanaPaul CampbellCecilia CanepaMireia CanteroPauline Caraux-PazSheila CárcelChiara Simona CardellinoFilipa CardosoFilipe CardosoNelson CardosoSofia CardosoSimone CarelliNicolas CarlierThierry CarmoiGayle CarneyInês CarquejaMarie-Christine CarretFrançois Martin CarrierIda CarrollGail CarsonMaire-Laure CasanovaMariana CascãoSiobhan CaseyJosé CasimiroBailey CassandraSilvia CastañedaNidyanara CastanheiraGuylaine Castor-AlexandreHenry CastrillónIvo CastroAna CatarinoFrançois-Xavier CatherinePaolo CattaneoRoberta CavalinGiulio Giovanni CavalliAlexandros CavayasAdrian CeccatoMinerva Cervantes-GonzalezAnissa ChairCatherine ChakveatzeAdrienne ChanMeera ChandChristelle Chantalat AugerJean-Marc ChapplainJulie ChasMobin ChaudryJonathan Samuel Chávez IñiguezAnjellica ChenYih-Sharng ChenMatthew Pellan ChengAntoine CheretThibault ChiarabiniJulian ChicaCatherine ChirouzeDavide ChiumelloSung-Min ChoBernard CholleyMarie-Charlotte ChopinJose Pedro CidadeJosé Miguel Cisneros HerrerosAnna CiulloEmma ClarkeJennifer ClarkeSara ClohiseyPerren CobbCassidy CodanCaitriona CodyAlexandra CoelhoMegan ColesGwenhaël ColinMichael CollinsSebastiano Maria ColomboPamela CombsMarie ConnorAnne ConradSofía ContrerasElaine ConwayGraham CookeMary CoplandHugues CordelAmanda CorleySabine CornelisAlexander Daniel CornetArianne Joy CorpuzAndrea CortegianiGrégory CorvaisierEmma CostiganCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseRachel CreganSabine CroonenGloria CrowlJonathan CrumpClaudina CruzJuan Luis Cruz BermúdezJaime Cruz RojoMarc CseteAilbhe CullenGer CurleyElodie CurlierColleen CurranPaula CustodioAna da Silva FilipeCharlene da SilveiraAl-Awwab DabalizAndrew DagensDarren DahlyHeidi DaltonJo DaltonSeamus DalyJuliana DamasNick DanemanCorinne DanielEmmanuelle DankwaJorge DantasFrédérick D’aragonGillian de LoughryDiego de MendozaEtienne de MontmollinRafael Freitas de Oliveira FrançaAna Isabel de Pinho OliveiraRosanna de RosaThushan de SilvaPeter de VriesJillian DeaconDavid DeanAlexa DebardMarie-Pierre DebrayNathalie DecastroWilliam DechertLauren DeconninckRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneAndrea Dell’amorePierre DelobelCorine DelsingElisa DemonchyEmmanuelle DenisDominique DeplanquePieter DepuydtDiane DescampsMathilde DesvalléesSanti DewayantiPathik DhangerAlpha DialloSylvain DiamantisAndré DiasJuan Jose DiazPriscila DiazKévin DidierJean-Luc DiehlWim DieperinkJérôme DimetVincent DinotFara DiopAlphonsine DioufYael DishonFélix DjossouAnnemarie DochertyHelen DohertyArjen DondorpChristl DonnellyMaria DonnellyChloe DonohueSean DonohueYoann DonohuePeter DoranCéline DorivalEric D’ortenzioJames Joshua DouglasNathalie DournonTriona DownerJoanne DowneyMark DowningTom DrakeAoife DriscollClaudio Duarte FonsecaVincent DubéeFrançois DubosAlexandre DucancelleSusanne DudmanPaul DunandJake DunningMathilde DuplaixEmanuele Durante-MangoniLucian DurhamBertrand DussolJuliette DuthoitXavier DuvalAnne Margarita Dyrhol-RiiseMarco Echeverria-VillalobosSiobhan EganCarla EiraMohammed El SanharawiSubbarao ElapavaluruBrigitte ElharrarJacobien EllerbroekPhilippine EloyTarek ElshazlyIsabelle EnderleTomoyuki EndoIlka EngelmannVincent EnoufOlivier EpaulardMartina EscherMariano EsperattiHélène EsperouCatarina Espírito SantoMarina Esposito-FareseJoão EstevãoManuel EtienneNadia EttalhaouiAnna Greti EverdingMirjam EversIsabelle FabreMarc FabreAmna FaheemArabella FahyCameron FairfieldZul FakarKomal FareedPedro FariaAhmed FarooqArie Zainul FatoniKarine FaureRaphaël FavoryMohamed FayedNiamh FeelyLaura FeeneyJorge FernandesMarília Andreia FernandesSusana FernandesFrançois-Xavier FerrandEglantine Ferrand DevougeJoana FerrãoMário FerrazBenigno FerreiraBernardo FerreiraIsabel FerreiraSílvia FerreiraRicard Ferrer-RocaNicolas FerriereCéline FickoJuan FiordaThomas FlamentClara FlateauTom FletcherLetizia Lucia FlorioDeirdre FlynnClaire FoleyJean FoleyVictor FominTatiana FonsecaPatricia FontelaSimon ForsythDenise FosterGiuseppe FotiErwan FournMarianne FraherDiego Franch-LlasatChristophe FraserJohn FraserMarcela Vieira FreireAna Freitas RibeiroCraig FrenchCaren FriedrichStéphanie FryNora FuentesMasahiro FukudaArgin GValérie GaborieauRostane GaciMassimo GagliardiJean-Charles GagnardAmandine Gagneux-BrunonSérgio GaiãoLinda Gail SkeiePhil GallagherCarrol GambleArthur GaranRebekha GarciaNoelia García BarrioNavya GarimellaDenis GarotValérie GarraitBasanta GauliNathalie GaultAisling GavinAnatoliy GavrylovAlexandre GaymardJohannes GebauerEva GeraudLouis Gerbaud MorlaesNuno GermanoJade GhosnMarco GianiJess GibsonTristan GiganteMorgane GilgElaine GilroyGuillermo GiordanoMichelle GirvanValérie GissotDaniel GlikmanPetr GlybochkoEric GnallGeraldine GocoFrançois GoehringerSiri GoepelJean-Christophe GoffardJonathan GolobJoan Gómez-JunyentMarie GominetAlicia GonzalezPatricia GordonIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokMargarite GrableJeronimo GrafEdward Wilson GrandinPascal GranierGiacomo GrasselliChristopher GreenCourtney GreeneWilliam GreenhalfSegolène GreffeDomenico Luca GriecoMatthew GriffeeFiona GriffithsAlbert GroenendijkAnja Grosse LordemannHeidi GrunerYusing GuJérémie GuedjMartin GuegoDewi GuellecAnne-Marie GuerguerianDaniela GuerreiroRomain GueryAnne GuillaumotLaurent GuilleminaultMaisa Guimarães de CastroThomas GuimardMarieke HaalboomDaniel HaberHannah HabrakenAli HachemiNadir HadriFakhir HaidriSheeba HakakAdam HallMatthew HallSophie HalpinJawad HameedAnsley HamerRebecca HamidfarTerese HammondRashan HaniffaHayley HardwickEwen HarrisonJanet HarrisonSamuel Bernard Ekow HarrisonMohd Shahnaz HasanJunaid HashmiMuhammad HayatAilbhe HayesLeanne HaysJan HeermanLars HeggelundRoss HendryMartina HennessyMaxime HentzienAndrew HersheyLiv HesstvedtAstarini HidayahDawn HigginsEibhilin HigginsRupert HigginsRita HinchionSamuel HintonHikombo HitotoAntonia HoAlexandre HoctinIsabelle HoffmannOscar HoitingRebecca HoltJan Cato HolterPeter HorbyJuan Pablo HorcajadaKoji HoshinoKota HoshinoIkram HouasCatherine HoughJimmy Ming-Yang HsuJean-Sébastien HulotStella HuoAbby HurdIqbal HussainSamreen IjazArfan IkramHajnal-Gabriela IllesPatrick ImbertMohammad ImranRana Imran SikanderAftab ImtiazHugo InácioCarmen Infante DominguezMariachiara IppolitoSarah IsgettTiago IsidoroMargaux IsnardDaniel IvulichDanielle JaafarSalma JaafouraJulien JabotClare JacksonNina JamiesonPierre JaquetColine Jaud-FischerStéphane JaureguiberryFlorence JegoSynne JenumRuth GarcíaCédric JosephMark JosephSwosti JoshiMercé JourdainPhilippe JouvetAnna JungDafsah JuzarOuifiya KafifFlorentia KaguelidouSabina KaliSmaragdi KalomoiriDarshana Hewa KandambyChris KandelDarakhshan KanwalAnant KatariaKevin KatzChristy KayHannah KeaneSeán KeatingAndrea KellyAoife KellyClaire KellyNiamh KellySadie KellyYvelynne KellyMaeve KelseyKalynn KennonMaeve KernanYounes KerroumiSharma KeshavImrana KhalidOsama KhalidAntoine KhalilCoralie KhanIrfan KhanQuratul Ain KhanSushil KhanalAbid KhatakAmin KhawajaMichelle KhoSaye KhooNasir KhosoYuri KidaPeter KiizaBeathe Kiland GranerudAnders Benjamin KildalAntoine KimmounDetlef Kindgen-MillesNobuya KitamuraPaul KlenermanRob KlontGry Kloumann BekkenStephen KnightRobin KobbeChamira KodippilyMalte Kohns VasconcelosSabin KoiralaCaroline KosgeiArsène KpangonKarolina KrawczykOksana KruglovaDeepali KumarMukesh KumarBharath Kumar Tirupakuzhi VijayaraghavanPavan Kumar VechamDinesh KuriakoseEthan KurtzmanDemetrios KutsogiannisGalyna KutsynaKonstantinos KyriakoulisMarie LachatreMarie LacosteJohn LaffeyMarie LagrangeFabrice LaineOlivier LairezSanjay LakheyAntonio LaluezaMarc LambertFrançois LamontagneMarie Langelot-RichardVincent LangloisEka Yudha LantangMarina LanzaCédric LaouénanSamira LaribiDelphine LariviereStéphane LasryNaveed LatifOdile LaunayDidier LaureillardYoan Lavie-BadieAndrew LawCassie LawrenceTeresa LawrenceMinh LeClément Le BihanCyril Le BrisGeorges Le FalherLucie Le FevreQuentin Le HingratMarion Le MaréchalSoizic Le MestreGwénaël Le MoalVincent Le MoingHervé Le NagardPaul Le TurnierEma LealMarta Leal SantosJames LeeJennifer LeeSu Hwan LeeTodd LeeGary LeemingBénédicte LefebvreLaurent LefebvreBenjamin LefèvreSylvie LegacJean-Daniel LelievreFrançois LelloucheAdrien LemaignenVéronique LemeeAnthony LemeurGretchen LemminkJenny LennonRafael LeónMarc LeoneMichela LeoneFrançois-Xavier LescureOlivier LesensMathieu LesouhaitierAmy 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MartinGuillaume Martin-BlondelMartin MartinotAna MartinsJoão MartinsNuno MartinsCaroline Martins RegoGennaro MartucciOlga MartynenkoEva Miranda MarwaliDavid MasloveSabina MasonSobia MasoodBasri Mat NorBasri Mat NorMoshe MatanMeghena MathewDaniel MathieuMathieu MatteiRomans MatulevicsLaurence MaulinMichael MaxwellJavier MaynarThierry MazzoniNatalie Mc EvoyLisa Mc SweeneyColin McarthurColin McarthurAine MccarthyAnne MccarthyColin MccloskeyRachael McconnochieSherry McdermottSarah McdonaldAine McelroySamuel McelweeVictoria MceneanyAllison McgeerChris MckayJohnny MckeownKenneth McleanPaul McnallyBairbre McnicholasElaine McpartlanEdel MeaneyCécile Mear-PassardMaggie MechlinMinahel AtifMaqsood MeherFerruccio MeleLuis MeloKashif MemonJoao Joao MendesOgechukwu MenkitiKusum MenonFrance MentréAlexander MentzerEmmanuelle MercierNoémie MercierAntoine MerckxMayka Mergeay-FabreBlake MerglerAntónio MesquitaOsama MetwallyAgnès MeybeckDan MeyerAlison MeynertVanina MeysonnierAmina MezianeMehdi MezidiCéline MichelangleiIsabelle MicheletVladislav MihnovitAsma MoinDavid MolinaElena MolinosBrenda MolloyMary MoneAgostinho MonteiroClaudia MontesGiorgia MontrucchioSarah MooreShona MooreLina Morales CelyLucia MoroCatherine MotherwayAna MotosHugo MouquetClara Mouton PerrotJulien MoyetAisha Kalsoom MuftiJimmy MullaertFredrik MüllerKarl Erik MüllerDaniel MunblitSyed MuneebNadeem MunirAisling MurphyAisling MurphyLorna MurphyMarlène MurrisHimed MusaabHimasha MuvindiDimitra Melia MyrodiaFarah Nadia Mohd-HanafiahDave NagpalAlex NagrebetskyNageswaran NarayananRashid Nasim KhanAlasdair Nazerali-MaitlandNadège NeantNikita NekliudovRaul NetoEmily NeumannPauline Yeung NgAnthony NghiDuc NguyenOrna Ni ChoileainNiamh Ni LeathlobhairPrompak NitayavardhanaStephanie NonasMarion NoretLisa NormanAlessandra NotariMahdad NoursadeghiAdam NowinskiSaad NseirJose NunezNurnaningsih NurnaningsihElsa NyamankollyFionnuala BrienAnnmarie CallaghanAnnmarie O’callaghanGiovanna OcchipintiDerbrenn OconnorMax O’donnellTawnya OgstonTakayuki OguraSophie O’halloranKatie O’hearnJoão OliveiraLarissa OliveiraDavid OngWilna OosthuyzenAnne OpavskyPeter OpenshawSaijad OrakzaiClaudia Milena Orozco-ChamorroJamel OrtolevaJavier OsatnikLinda O’sheaMiriam O’sullivanNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesAmanda PalaciosMario PalaciosMassimo PalmariniGiovanna PanarelloHem PaneruMauro PanigadaNathalie PansuAurélie PapadopoulosRachael ParkeMelissa ParkerBriseida ParraTaha PashaJérémie PasquierBruno PasteneFabian PataunerLuís PatrãoPatricia PatricioJuliette PatrierLisa PattersonRajyabardhan PattnaikChristelle PaulMical PaulJorge PaulosWilliam PaxtonJean-François PayenFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneMare PejkovskaPaolo PelosiIthan PeltanRui PereiraDaniel PerezLuis PerielThomas PerpointAntonio PesentiVincent PestreLenka PetrouMichele PetrovicVentzislava Petrov-SanchezFrank Olav PettersenGilles PeytavinScott PharandWalter PicardOlivier PiconeCarola PierobonDjura PiersmaCarlos PimentelRaquel PintoCatarina PiresIsabelle PironneauLionel PirothRiinu PiusLaurent PlantierJulien PoissyRyadh PokeerbuxSergio PoliGeorgios PollakisDiane PonscarmeAndra-Maris PostDouwe PostmaPedro PovoaDiana PóvoasJeff PowisSofia PrapaSébastien PréauChristian PrebensenJean-Charles PreiserAnton PrinssenMark PritchardGamage Dona Dilanthi PriyadarshaniLucia ProençaSravya PudotaOriane PuéchalBambang Pujo SemediMathew PulickenGregory PurcellLuisa QuesadaVilmaris Quinones-CardonaVíctor Quirós GonzálezElse Quist-PaulsenMohammed QuraishiChristian RabaudEbenezer RabindrarajanAldo RafaelMarie RafiqArsalan RahutullahFernando RainieriPratheema RamachandranNagarajan RamakrishnanJosé RamalhoBlandine RammaertGrazielle Viana RamosAsim RanaRajavardhan RangappaRitika RanjanChristophe RappAasiyah RashanThalha RashanGhulam RasheedMenaldi RasminIndrek RätsepCornelius RauAli RazaAndre RealStanislas RebaudetSarah RedlBrenda ReeveAttaur RehmanLiadain ReidLiadain ReidDag Henrik ReikvamRenato ReisJonathan RemppisMartine RemyHongru RenHanna RenkAnne-Sophie ResseguierMatthieu RevestOleksa RewaTiago ReyesMaria Ines RibeiroDavid RichardsonDenise RichardsonLaurent RichierJordi RieraAna RiosAsgar RishuPatrick RispalKarine RissoNicholas RizerChiara RobbaAndré RobertoStephanie RobertsDavid RobertsonOlivier RobineauFerran Roche-CampoPaola RodariSimão RodeiaJulia Rodriguez AbreuBernhard RoesslerPierre-Marie RogerAmanda RojekJuliette RomaruRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerAndrea RossaneseMatteo RossettiBénédicte RossignolPatrick RossignolStella RoussetCarine RoyBenoît RozeDesy RusmawatiningtyasClark RussellMaeve RyanMaria RyanSteffi RyckaertAleksander Rygh HoltenIsabela SabaSairah SadafMusharaf SadatValla SahraeiNadia SaidaniMaximilien Saint-GillesPranya SakiyalakNawal SalahuddinLeonardo SalazarJodat SaleemGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorOlivier SanchezAngel Sanchez-MirallesVanessa 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SoJoshua SolomonTom SolomonEmily SomersAgnès SommetMyung Jin SongRima SongTae SongJack Song ChiaAlbert SottoEdouard SoumAna Chora SousaMarta SousaMaria Sousa UvaAlexandra SperryElisabetta SpinuzzaB. DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelAmi StuartDavid StuartGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicMagdalena SurovcováAndrey SvistunovKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziLysa TaghersetSara TalebJelmer TalsmaMaria Lawrensia TampubolonHiroyuki TanakaHuda TaqdeesArshad TaqiCoralie TardivonPierre TattevinM. Azhari TaufikHassan TawfikRichard TedderJoão TeixeiraSofia TejadaMarie-Capucine TellierFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAnand ThakurV. ThibaultSimon-Djamel ThibervilleBenoît ThillShaun ThompsonEmma ThomsonRyan ThwaitesPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitBharath Kumar Tirupakuzhi VijayaraghavanNoémie TissotMaria TokiKristian TonbyMarta TorreAntoni TorresMargarida TorresHernando Torres-ZevallosMichael TowersTony TrapaniThéo TreouxCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteJean-Marie TurmelLance TurtlePawel TwardowskiMakoto UchiyamaP. UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresAmélie ValranStijn van de VeldeMarcel van den BergeJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van Der WerfLaura van GulikJarne van HattemCarolien van NettenIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseCharline VauchyAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoBenoit VisseauxHannah VisserChiara VitielloHarald VonkemanFanny VuottoWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbJia WeiKatharina WeilSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsEvert-Jan WilsNg Wing YiuCalvin WongIoannis XynogalasMasaki YamazakiYazdan YazdanpanahCécile YelnikStephanie YerkovichToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeMaram ZahranMaria ZambonAlberto ZanellaHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : University of Oxford Universidad de La Sabana [Chía, Cundinamarca, Colombia] = La Sabana University [Chía, Cundinamarca, Colombia] Infection, Anti-microbiens, Modélisation, Evolution University of Oxford ARN bactériens et médecine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut Pasteur [Paris] Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

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Fichiers liés : s13054-022-04155-1.pdf

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