Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 10/03/2022
• Auteurs : Damien Luque PazPierre TattevinPaul LoubetFrançois BénézitV. ThibaultFabrice LainéPhilippe VanhemsSelilah AmourBruno LinaXavier DuvalAnne-Sophie L’honneurNadhira FidouhChristine VallejoSophie AlainFlorence GaltierVincent FoulongneGisèle LagathuNezha LenziZineb LesieurOdile LaunayStéphane JouneauP. LoulergueS. MomcilovicJ. MiraN. MarinJ. CharpentierA. RegentR. KanaanF. DumasB. DoumencM. LachatreT. SzwebelJ. KansaoY. CostaJ. AlexandraH. BecheurK. BelghalemJ. BernardAlexandre BleibtreuM. BoisseauR. BoriesO. BrugiereF. BrunetC. BurdetE. CasalinoM. CaserisC. ChansiauxM. ChauchardP. ChavanceC. ChoquetA. Cloppet-FontaineL. ColosiB. CousetB. CrestaniF. CrocketA. DebitK DelanoeVéronique DescampsP. DieudeA. DossierN. DouronE. DupeyratN. EmeyratC. FernetT. GoulenokS. HarentR. JouenneA. JustetAdrien LeleuI. LeratM. LilamandH. MalA. MarceauA.-C. MetivierK. OplelatoraT. PapoA.-L. PelletierL. PereiraP. PradereR PrommierP. RalainnazavaM. RanaivoisionA. Raynaud-SimonC. RiouxK. SacreV. VerryV. VuongY. YazdapanahN. HouhouP. GéraudV. DrissV. MaugueretL. CrantelleC. AgostiniM. RayF. LetoisThibault MuraC. SerrandS. NoslierA. GiordanoH. ChevassusE. NyiramigishaCarole ArnoldArnaud BourdinA. KonatéX. CapdevillaG. Du CailarA. TerminetH. BlainM. LegliseA. Le QuellecP. CorneL. LandreauKada KloucheA. BourgeoisM. SebbaneG. MouradH. LerayD. PostilS. AlcoleaE. Couve-DeaconS. RogezL. ArgaudM. CourRomain HernuMichel SimonT. BaudryK. TazarourteC. Bui-XuanJ. FattoumMartine ValetteS. RochasS. CochennecE. ThébaultM. RevestM. SébillotteA. Le BotM. BaldeyrouS. Patrat-DelonM. CailleauxC. Pronier
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Hospices Civils de Lyon Centre International de Recherche en Infectiologie Hospices Civils de Lyon Hospices Civils de Lyon F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) CIC - CHU Bichat Hôpital Cochin [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques CIC Montpellier Biocommunication en Cardio-Métabolique CHU Montpellier = Montpellier University Hospital CHU Montpellier = Montpellier University Hospital Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) CIC Cochin Pasteur Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.

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Fichiers liés : 2022 Luque-Paz et al., Chronic use of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 09/03/2022
• Auteurs : Charles DussiauAgathe BoussaroqueMathilde GaillardClotilde BravettiLaila ZaroiliCamille KnospChloé FriedrichPhilippe AsquierLise WillemsLaurent QuintDidier BouscaryMichaëla FontenayThibault EspinasseAdriana PlesaPierre SujobertOlivier GandrillonOlivier Kosmider
• Organismes : Institut Cochin Hôpital Cochin [AP-HP] Institut Cochin Laboratoire de biologie et modélisation de la cellule Institut Cochin Institut Cochin Institut Cochin Institut Cochin Hôpital Cochin [AP-HP] Pôle Santé Léonard de Vinci [Chambray-lès-Tours] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Américain de Paris Institut Cochin Hôpital Cochin [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] Institut Camille Jordan Modélisation multi-échelle des dynamiques cellulaires : application à l'hématopoïese Probabilités, statistique, physique mathématique Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Centre de Recherche en Cancérologie de Lyon Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Centre de Recherche en Cancérologie de Lyon Immuno-Biologie des Lymphomes [CIRI] Laboratoire de biologie et modélisation de la cellule Modélisation multi-échelle des dynamiques cellulaires : application à l'hématopoïese Institut Cochin Hôpital Cochin [AP-HP]
• Publié dans BMC Biology le 01/11/2020

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Résumé : Background: Mature blood cells arise from hematopoietic stem cells in the bone marrow by a process of differentiation along one of several different lineage trajectories. This is often represented as a series of discrete steps of increasing progenitor cell commitment to a given lineage, but as for differentiation in general, whether the process is instructive or stochastic remains controversial. Here, we examine this question by analyzing single-cell transcriptomic data from human bone marrow cells, assessing cell-to-cell variability along the trajectories of hematopoietic differentiation into four different types of mature blood cells. The instructive model predicts that cells will be following the same sequence of instructions and that there will be minimal variability of gene expression between them throughout the process, while the stochastic model predicts a role for cell-to-cell variability when lineage commitments are being made. Results: Applying Shannon entropy to measure cell-to-cell variability among human hematopoietic bone marrow cells at the same stage of differentiation, we observed a transient peak of gene expression variability occurring at characteristic points in all hematopoietic differentiation pathways. Strikingly, the genes whose cell-to-cell variation of expression fluctuated the most over the course of a given differentiation trajectory are pathway-specific genes, whereas genes which showed the greatest variation of mean expression are common to all pathways. Finally, we showed that the level of cell-to-cell variation is increased in the most immature compartment of hematopoiesis in myelodysplastic syndromes. Conclusions: These data suggest that human hematopoietic differentiation could be better conceptualized as a dynamical stochastic process with a transient stage of cellular indetermination, and strongly support the stochastic view of differentiation. They also highlight the need to consider the role of stochastic gene expression in complex physiological processes and pathologies such as cancers, paving the way for possible noise-based therapies through epigenetic regulation.

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Fichiers liés : s12915-022-01264-9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/03/2022
• Auteurs : Asya EkmenAurelie MeneretRomain ValabregueBenoit BerangerYulia WorbeJean-Charles LamySofien MehdiAnais HerveIsaac AdanyeguhGizem TemizPhilippe DamierDomitille GrasAgathe RoubertieJuliette PiardVincent NavarroEugenie MutezFlorence RiantQuentin WelniarzMarie VidailhetStéphane LehéricySabine MeunierCecile GalleaEmmanuel Flamand-Roze
• Organismes : Fondation ICM CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] Center for Magnetic Resonance Research [Minneapolis] Institut du Cerveau = Paris Brain Institute Centre d’Investigation Clinique de Nantes AP-HP Hôpital universitaire Robert-Debré [Paris] Institut des Neurosciences de Montpellier CHU Montpellier = Montpellier University Hospital Centre de génétique humaine [CHRU Besançon] Université de Franche-Comté Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Lille Neurosciences & Cognition - U 1172 Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal Fondation ICM Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Bern University Hospital [Berne] Universität Bern = University of Bern = Université de Berne Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Sorbonne Université Institut du Cerveau = Paris Brain Institute Laboratoire de Mécanique et d'Acoustique [Marseille] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Neurology le 01/11/2020

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Résumé : Background and objectives: The main culprit gene for paroxysmal kinesigenic dyskinesia, characterized by brief and recurrent attacks of involuntary movements, is PRRT2. The location of the primary dysfunction associated with paroxysmal dyskinesia remains a matter of debate and may vary depending on the etiology. While striatal dysfunction has often been implicated in these patients, evidence from preclinical models indicates that the cerebellum could also play a role. We aimed to investigate the role of the cerebellum in the pathogenesis of PRRT2-related dyskinesia in humans. Methods: We enrolled 22 consecutive right-handed patients with paroxysmal kinesigenic dyskinesia with a pathogenic variant of PRRT2 and their matched controls. Participants underwent a multimodal neuroimaging protocol. We recorded anatomic and diffusion-weighted MRI, as well as resting-state fMRI, during which we tested the aftereffects of sham and repetitive transcranial magnetic stimulation applied to the cerebellum on endogenous brain activity. We quantified the structural integrity of gray matter using voxel-based morphometry, the structural integrity of white matter using fixel-based analysis, and the strength and direction of functional cerebellar connections using spectral dynamic causal modeling. Results: Patients with PRRT2 had decreased gray matter volume in the cerebellar lobule VI and in the medial prefrontal cortex, microstructural alterations of white matter in the cerebellum and along the tracts connecting the cerebellum to the striatum and the cortical motor areas, and dysfunction of cerebellar motor pathways to the striatum and the cortical motor areas, as well as abnormal communication between the associative cerebellum (Crus I) and the medial prefrontal cortex. Cerebellar stimulation modulated communication within the motor and associative cerebellar networks and tended to restore this communication to the level observed in healthy controls. Discussion: Patients with PRRT2-related dyskinesia have converging structural alterations of the motor cerebellum and related pathways with a dysfunction of cerebellar output toward the cerebello-thalamo-striato-cortical network. We hypothesize that abnormal cerebellar output is the primary dysfunction in patients with a PRRT2 pathogenic variant, resulting in striatal dysregulation and paroxysmal dyskinesia. More broadly, striatal dysfunction in paroxysmal dyskinesia might be secondary to aberrant cerebellar output transmitted by thalamic relays in certain disorders. Trial registration information: ClinicalTrials.gov identifier: NCT03481491.

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Fichiers liés : NEUROLOGY-2022-174716v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/03/2022
• Auteurs : Julia De TernayPierre LeblancPhilippe MichelAmine BenyaminaMickaël NaassïlaBenjamin Rolland
• Organismes : Hôpital Edouard Herriot [CHU - HCL] Hospices Civils de Lyon Research on Healthcare Performance Research on Healthcare Performance Hospices Civils de Lyon Hôpital Paul Brousse Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV Centre Hospitalier le Vinatier [Bron] Hôpital Edouard Herriot [CHU - HCL] Psychiatric Disorders, Neuroscience Research and Clinical Research Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
• Publié dans Harm Reduction Journal le 29/10/2020

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Résumé : Over the last decade, one-month alcohol abstinence campaigns (OMACs) have been implemented within the general population in an increasing number of countries. We identified the published studies reporting data on OMACs to explore the following aspects: profile of participants, rates and factors associated with the completion of the abstinence challenge, and outcomes and harm reduction benefits in participating in the challenges. We screened 322 records, including those found in the grey literature, and reviewed 6 studies and 7 Dry July Annual Reports. Compared to non-participating alcohol users, participants were more likely to be female, have a higher income, and a higher level of education. They were heavier drinkers and were more concerned by the consequences of alcohol on health and by their health in general. Participants who achieved the one-month abstinence challenge were lower drinkers and more likely to have registered on the campaign-related Internet communities. Both successful and unsuccessful participants frequently reported health benefits, including sleep improvement and weight loss. Successful participants were more likely to durably change their alcohol drinking habits. Overall, OMACs provide short- or mid-term harm reduction benefits for both successful and unsuccessful participants. Findings were limited by the paucity of studies, their observational nature, and heterogeneity in the features of the different national campaigns, which would probably gain in enhanced internationalization.

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Fichiers liés : 12954_2022_Article_603.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/03/2022
• Auteurs : Florian PerraudFiona EcarnotMélanie LoiseauAlexandra LaurentAlicia FournierFlorent LheureuxC BinquetJean-Philippe RigaudNicolas Meunier-BeillardJean-Pierre Quenot
• Organismes : Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] Laboratoire de Psychologie - UFC (UR 3188)
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Purpose During the COVID pandemic, many hospitals had to mobilize reinforcement healthcare workers, especially in intensive care (ICUs). We investigated the perceptions and experiences of reinforcement workers deployed to ICUs, and the impact of deployment on their personal and professional lives. Methods For this qualitative study, a random sample of 30 reinforcement workers was drawn from 4 centres participating in the larger PsyCOVID-ICU study. Individual semi-structured interviews were held, recorded, transcribed and analyzed by thematic analysis. Results Thirty interviews were performed from April to May 2021 (22 nurses, 2 anesthesiology nurses, 6 nurses’ aides). Average age was 36.8±9.5 years; 7 participants had no ICU experience. Four major themes emerged, namely: (1) Difficulties with integration, especially for those with no ICU experience; (2) lack of training; (3) difficulties with management, notably a feeling of insufficient communication; (4) Mental distress relating to the unusual work and fear of contaminating their entourage. Conclusion Healthcare workers deployed as reinforcements to ICUs at the height of the pandemic had a unique experience of the crisis, and identified important gaps in organisation and preparation. They also suffered from a marked lack of training, given the stakes in the management of critically ill patients in the ICU.

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Fichiers liés : ffbbd62b8f83c17275ba4e8fdc2fbfae.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/03/2022
• Auteurs : Alexandre DescampsNezha LenziFlorence GaltierFabrice LainéZineb LesieurPhilippe VanhemsSélilah AmourAnne-Sophie L’honneurNadhira FidouhVincent FoulongneGisèle LagathuXavier DuvalCorinne MerleBruno LinaFabrice CarratOdile LaunayPaul Loubet
• Organismes : CIC Cochin Pasteur F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) CIC Montpellier Centre Hospitalier Régional Universitaire [Montpellier] F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Biocommunication en Cardio-Métabolique Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Centre International de Recherche en Infectiologie F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Hospices Civils de Lyon Centre International de Recherche en Infectiologie Hospices Civils de Lyon Hôpital Cochin [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Régional Universitaire [Montpellier] Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Centre Hospitalier Régional Universitaire [Montpellier] Hospices Civils de Lyon Institut Pierre Louis d'Epidémiologie et de Santé Publique CIC Cochin Pasteur F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Hôpital Cochin [AP-HP] Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
• Publié dans European Respiratory Journal le 23/10/2020

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Résumé : Objectives - The purpose of this study was to describe the clinical characteristics and in-hospital and post-discharge outcomes of respiratory syncytial virus (RSV) infection among adults hospitalised with influenza-like illness (ILI) and compared against patients admitted for influenza. Methods - Adults hospitalised with ILI were prospectively included from five French university hospitals over two consecutive winter seasons (2017/2018 and 2018/2019). RSV and influenza virus were detected by multiplex reverse transcription PCR on nasopharyngeal swabs. RSV-positive patients were compared to RSV-negative and influenza-positive hospitalised patients. Poisson regression models were used to estimate the adjusted prevalence ratio (aPR) associated with in-hospital and post-discharge outcomes between RSV and influenza infections. The in-hospital outcome was a composite of the occurrence of at least one complication, length of stay ≥7 days, intensive care unit admission, use of mechanical ventilation and in-hospital death. Post-discharge outcome included 30- and 90-day all-cause mortality and 90-day readmission rates. Results - Overall, 1428 hospitalised adults with ILI were included. RSV was detected in 8% (114 of 1428) and influenza virus in 31% (437 of 1428). Patients hospitalised with RSV were older than those with influenza (mean age 73.0 68.8 years, p=0.015) with a higher frequency of chronic respiratory or cardiac disease (52% 39%, p=0.012, and 52% 41%, p=0.039, respectively) and longer hospitalisation duration (median stay 8 6 days, p<0.001). Anti-influenza therapies were less prescribed among RSV patients than influenza patients (20% 66%, p<0.001). In-hospital composite outcome was poorer in RSV patients (aPR 1.5, 95% CI 1.1-2.1) than in those hospitalised with influenza. No difference was observed for the post-discharge composite outcome (aPR 1.1, 95% CI 0.8-1.6). Conclusion - RSV infection results in serious respiratory illness, with worse in-hospital outcomes than influenza and with similar midterm post-discharge outcomes.

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Fichiers liés : hal-03333590.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/03/2022
• Auteurs : Benoît SansonCaroline StalensCéline GuienLuisa VillaCatherine EngSitraka RabarimeriarijaonaRafaelle BernardPascal CintasGuilhem SoléVincent TiffreauAndoni Echaniz-LagunaArmelle MagotRaul Juntas MoralesFrançois Constant BoyerAleksandra Nadaj-PaklezaAgnès Jacquin-PiquesChristophe BéroudSabrina SacconiBlandine AcketJean-Christophe AntoineShahram AttarianGuillaume BassezAnne-Laure Bédat-MilletAnthony BéhinRémi BellanceMichela BiscigliaVéronique BombartRosalie BoitetPascale BonnetFrançoise BouhourCélia BoutteBrigitte ChabrolJean-Baptiste ChansonFrançoise ChaponAriane ChoumertPauline CoignardJean-Yves CornuBenoît DaubailElisa de La CruzLéa DeclerckCapucine DelattreFlorence DemurgerVéronique DulieuAurélie DurufléFanny DuvalFlorence EsselinTeresinha EvangelistaBruno EymardAnthony FaivreLéonard FéassonXavier FerrerFrançois FeuvrierOlivier FlabeauMélanie FradinAlain FurbyJérémy GarciaHélène Gervais-BernardTeresa GidaroKarima GhorabMarc JeanpierreHubert JournelArnaud LacourPascal LaforêtEmmeline LagrangeValérie LayetGérard LeclaireJean-Luc Le GuietGwenaël Le GuyaderFrançois LeroyFrance LeturcqNicolas LévySarah Léonard-LouisLaurent MagyEdoardo MalfattiMarion MasingueGilles MazaltarineDominique MénardMaud MichaudMarie-Christine Minot-MyhiéMarie-Doriane MorardJuliette NectouxKarine NguyenJulie NicometteJean-Baptiste NourySybille PellieuxLaetitia Percebois-MacadréYann PéréonSolange Perrin-CallotPhilippe PetiotSylviane PeudenierBénédicte PontierFlorence PortetJean PougetMarguerite PreudhommeHélène RauscentDimitri RenardAudrey RiouFrançois RivierEmmanuelle Salort-CampanaStéphane SchaefferJean-Philippe SimonAurélie SiriMarco SpinazziTanya StokovicJuliette SvahnFrançois TabaraudFrédéric TaitheCéline TardChristel Thauvin-RobinetPhilippe ThoumieClaire-Lise Tournier-GervasonChristine TranchantJon Andoni UrtizbereaChristophe VialMichel VidaudFabien Zagnoli
• Organismes : Centre Hospitalier Universitaire de Nice Association française contre les myopathies Marseille medical genetics - Centre de génétique médicale de Marseille Centre Hospitalier Universitaire de Nice Association française contre les myopathies Département de génétique médicale [Hôpital de la Timone - APHM] Assistance Publique - Hôpitaux de Marseille Département de génétique médicale [Hôpital de la Timone - APHM] Assistance Publique - Hôpitaux de Marseille Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] French National Reference Center for Rare Neuropathies Petites Molécules de neuroprotection, neurorégénération et remyélinisation Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Montpellier = Montpellier University Hospital Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire d'Angers Hôpitaux Universitaires de Strasbourg Service de Neurophysiologie Clinique (CHU Dijon) Centre des Sciences du Goût et de l'Alimentation [Dijon] Marseille medical genetics - Centre de génétique médicale de Marseille Département de génétique médicale [Hôpital de la Timone - APHM] Centre Hospitalier Universitaire de Nice Institut de Recherche sur le Cancer et le Vieillissement Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH Observatoire National Français des patients atteints de DMFSH 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• Publié dans Orphanet Journal of Rare Diseases le 27/10/2020

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Résumé : Facioscapulohumeral muscular dystrophy (FSHD) is among the most prevalent muscular dystrophies and currently has no treatment. Clinical and genetic heterogeneity are the main challenges to a full comprehension of the physiopathological mechanism. Improving our knowledge of FSHD is crucial to the development of future therapeutic trials and standards of care. National FSHD registries have been set up to this end. The French National Registry of FSHD combines a clinical evaluation form (CEF) and a self-report questionnaire (SRQ), filled out by a physician with expertise in neuromuscular dystrophies and by the patient, respectively. Aside from favoring recruitment, our strategy was devised to improve data quality. Indeed, the pairwise comparison of data from 281 patients for 39 items allowed for evaluating data accuracy. Kappa or intra-class coefficient (ICC) values were calculated to determine the correlation between answers provided in both the CEF and SRQ. Results Patients and physicians agreed on a majority of questions common to the SRQ and CEF (24 out of 39). Demographic, diagnosis- and care-related questions were generally answered consistently by the patient and the medical practitioner (kappa or ICC values of most items in these groups were greater than 0.8). Muscle function-related items, i.e. FSHD-specific signs, showed an overall medium to poor correlation between data provided in the two forms; the distribution of agreements in this section was markedly spread out and ranged from poor to good. In particular, there was very little agreement regarding the assessment of facial motricity and the presence of a winged scapula. However, patients and physicians agreed very well on the Vignos and Brooke scores. The report of symptoms not specific to FSHD showed general poor consistency. Conclusions Patient and physician answers are largely concordant when addressing quantitative and objective items. Consequently, we updated collection forms by relying more on patient-reported data where appropriate. We hope the revised forms will reduce data collection time while ensuring the same quality standard. With the advent of artificial intelligence and automated decision-making, high-quality and reliable data are critical to develop top-performing algorithms to improve diagnosis, care, and evaluate the efficiency of upcoming treatments.

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Fichiers liés : 2022 Sanson et al., Convergence of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/03/2022
• Auteurs : Jonas VanardoisRoger FrançoisePierre TrapPhilippe GoncalvesPierre LanariJean-Louis PaquetteDidier MarquerFlorence CagnardBenjamin Le BayonJérémie MelletonFabrice Barou
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Géosciences Montpellier Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249) Institute of Geological Sciences [Bern] Laboratoire Magmas et Volcans Laboratoire Chrono-environnement (UMR 6249) Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Géosciences Montpellier
• Publié dans Journal of Metamorphic Geology le 25/10/2020

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Résumé : Mafic eclogites are found in many orogens as lenses embedded in quartzofeldspathic migmatites. These high-pressure relics are interpreted either as remnants of ancient sutures and thus formed during oceanic subduction or as fragments of lower crust exhumed from the root of orogenic thickened crust. It is critical to distinguish between these two endmember scenarios as the resulting palaeogeographic and geodynamic reconstructions may significantly differ. In this contribution, we investigated eclogite relics from Lac Cornu in the Aiguilles-Rouges massif, one of the External Crystalline Massifs of the Western Alps. Phase equilibrium modelling suggests that these mafic rocks were buried along a prograde path (M1) from ~600°C/1.2 to 1.6 GPa to peak conditions of ~630–775°C and >1.6 GPa. Zircon rims, with a rare earth element signature typical of eclogite facies zircon (no Eu anomalies, flat HREE spectrum), and rutile were dated by U–Th–Pb laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) at c. 335–330 Ma. Prograde deformation has not been identified in the field and is only recognized thanks to the crystallographic preferred orientation (CPO) of inclusions of omphacite and rutile in garnet. Peak pressure conditions were followed by a decompression stage (M2) from ~760°C/1.4 GPa to ~600–650°C/0.9 GPa supported by the breakdown of omphacite into plagioclase–clinopyroxene symplectite and the crystallization of plagioclase–amphibole corona around garnet. The M2 retrogression stage is associated with the development of a main sub-horizontal planar fabric and the CPO of minerals composing symplectite. This deformation stage is interpreted as the result of horizontal lower crustal flow. The final stage of exhumation (M3) is characterized by the replacement of symplectite and garnet by plagioclase and large euhedral amphibole and by the breakdown of rutile and ilmenite into titanite dated at c. 300 Ma. The CPO of titanite and amphibole are consistent with the development of vertical dextral shear zone in a transpressive regime. The combination of field observations and petrological, microtextural and geochemical analyses suggests that the mafic eclogites preserved in migmatitic rocks of the Aiguilles-Rouges massif are remnants of a continental lower crust exhumed and juxtaposed with lower-grade migmatites in crustal-scale vertical transpressive shear zones.

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Fichiers liés : Vanardois et al., accepte-2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2022
• Auteurs : Laura FilaireOlaf MercierAgathe Seguin-GiveletOlivier TiffetPierre Emmanuel FalcozPierre MordantPierre-Yves BrichonPhilippe LacosteAxel AubertPascal ThomasFrançoise Le Pimpec-BarthesIoana MolnarMagali VidalMarc FilaireGeraud Galvaing
• Organismes : Centre Jean Perrin [Clermont-Ferrand] Hôpital Marie-Lannelongue Institut Mutualiste de Montsouris Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Nouvel Hôpital Civil de Strasbourg Service de Chirurgie Thoracique et Vasculaire [Hôpital Bichat] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Clinique Belledone Service de chirurgie thoracique [Hôpital Nord - APHM] Hôpital Européen Georges Pompidou [APHP] Centre Jean Perrin [Clermont-Ferrand] CHU Gabriel Montpied [Clermont-Ferrand] Centre Jean Perrin [Clermont-Ferrand] Centre Jean Perrin [Clermont-Ferrand]
• Publié dans Interactive Cardiovascular and Thoracic Surgery le 22/10/2020

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Résumé : Abstract OBJECTIVES To report our experience on the management of superior vena cava graft infection. METHODS Between 2001 and 2018, patients with superior vena cava synthetic graft or patch reconstruction after resection of intrathoracic tumours or benign disease were selected retrospectively from the French EPITHOR database and participating thoracic centres. Our study population includes patients with superior vena cava graft infection, defined according to the MAGIC consensus. Superior vena cava synthetic grafts in an empyema or mediastinitis were considered as infected. RESULTS Of 111 eligible patients, superior vena cava graft infection occurred in 12 (11.9%) patients with a polytetrafluoroethylene graft secondary to contiguous contamination. Management consisted of either conservative treatment with chest tube drainage and antibiotics (n = 3) or a surgical graft-sparing strategy (n = 9). Recurrence of infection appears in 6 patients. Graft removal was performed in 2 patients among the 5 reoperated patients. The operative mortality rate was 25%. CONCLUSIONS Superior vena cava graft infection may develop as a surgical site infection secondary to early mediastinitis or empyema. Graft removal is not always mandatory but should be considered in late or recurrent graft infection or in infections caused by aggressive microorganisms (virulent or multidrug resistant bacteria or fungi).

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Fichiers liés : ivab337.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2022
• Auteurs : Nicolas GalloisBéatrice Alpha-BazinNicolas BremondPhilippe OrtetMohamed BarakatLaurie PietteAbbas Mohamad AliDavid LemairePierre LegrandNicolas TheodorakopoulosMagali FlorianiLaureline FevrierChristophe Den AuwerPascal ArnouxCatherine BerthomieuJean ArmengaudVirginie Chapon
• Organismes : Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Service de Pharmacologie et Immunoanalyse Médicaments et Technologies pour la Santé Laboratoire Innovations technologiques pour la Détection et le Diagnostic Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Synchrotron SOLEIL Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Laboratoire de recherche sur les transferts des radionucléides dans les écosystèmes terrestres Laboratoire d'écotoxicologie des radionucléides Laboratoire de recherche sur les transferts des radionucléides dans les écosystèmes terrestres Institut de Chimie de Nice Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) Service de Pharmacologie et Immunoanalyse Médicaments et Technologies pour la Santé Laboratoire Innovations technologiques pour la Détection et le Diagnostic Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB)
• Publié dans The International Society of Microbiologial Ecology Journal le 29/10/2020

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