Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 25/06/2025
• Auteurs : Natalie ZwingLena Voith von VoithenbergLaurent AlbertiSascha Michael GabrielJosep Monné RodriguezRomi FeddersenJean-Philippe FoyFrancesca DamiolaNicolas GadotPierre SaintignyBruno Gomes
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Dynamiques du Cancer, adaptation et modélisation Plateforme anatomopathologie recherche Lyon-Est Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Dynamiques du Cancer, adaptation et modélisation
• Publié dans Journal for Immunotherapy of Cancer le 24/10/2020

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Résumé : Background Head and neck squamous cell carcinoma (HNSCC) exhibits low response rates to immunotherapies, with only about 15–25% of patients responding to monotherapy and 30–45% to combination therapy. This limited effectiveness is attributed to significant intertumor and intratumor heterogeneity, which affects the immunological activity of individual tumors and their regions, thereby influencing immunotherapy outcomes. Various biomarkers at the gene and protein expression levels have been identified to predict the response to immunotherapy in HNSCC. Methods In this study, we evaluated intertumor heterogeneity using a 27-gene expression signature to stratify tumors by their immunologic activity status. We investigated intertumor heterogeneity at the molecular and cellular level and further analyzed intratumor spatial heterogeneity within and across these subgroups by using spatial multiomics approaches. Results Immunologically active tumors showed increased interferon-γ and interferon-α signaling and upregulation of major histocompatibility complex-I signaling and genes involved in antigen presentation. Chemokines such as CXCL8 and CXCL9 , which are crucial for immune cell recruitment, were differentially regulated. The spatial analysis revealed that active tumors tended to show higher autocorrelation of homogeneous regions with immune cell infiltration compared with inactive tumors. Proximity measures showed an increased colocalization of immune cells, particularly CD8+ T cells, T helper cells, and regulatory T cells, near tumor cells in active tumors. Despite this high immune infiltration, HNSCC often has an immunosuppressive microenvironment, which we observed as a colocalization of programmed cell death protein-1+ (PD-1+) cytotoxic T cells and cytotoxic T cells, indicating regional differences in active and exhausted cell ratios. Furthermore, upregulation of JAK-STAT3 signaling in active tumors was potentially associated with immune evasion. Conclusions The spatial analysis at multiple omics levels allowed for a detailed investigation of molecular and cell type markers to further distinguish between immunologically active and immunosuppressive microenvironments and their spatial heterogeneity. Our study demonstrates that, besides gene expression signatures, cell colocalization signatures can infer immunological activity in HNSCC, thus predicting immunotherapy response.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 25/06/2025
• Auteurs : Jill-Léa RamassamyPatricia TortevoyeBalthazar NtabGabriel CarlesJean-Pierre DrozPierre CouppiéGiovanni BegliominiJean-François CarodN’detodji-Bill WankpoKarim AbdelmoumenPhilippe V AfonsoOlivier CassarAntoine TalarminOlivier HermineLoïc EpelboinAmbroise MarçaisAntoine Gessain
• Organismes : Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Université Claude Bernard Lyon 1 Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Université de La Réunion Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Transmission, Réservoir et Diversité des Pathogènes - Transmission, Reservoir and Diversity of Pathogens [Institut Pasteur Guadeloupe, France] Institut Necker Enfants-Malades Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Université de Guyane Centre d'Investigation Clinique Antilles-Guyane Institut Necker Enfants-Malades Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology

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Résumé : Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). French Guiana, located in northeastern South America, is a region of high HTLV-1 endemicity with a multiethnic population. We conducted a comprehensive 30-year study of ATL cases diagnosed between 1990 and 2019, capturing nearly all confirmed ATL cases in the territory (n=137). The predominant subtypes were lymphoma (58%) and acute ATL (36%). Striking ethnic disparities emerged: 69% of patients were Maroons, and the median age at diagnosis was 43 years among Maroons versus 58 years among Creoles. Survival outcomes were uniformly poor, with median overall survival of 2.7 months for acute and 5.2 months for lymphoma ATL. In multivariate analysis, acute ATL subtype and hepatosplenomegaly at diagnosis were independently associated with worse survival. Complete HTLV-1 genome sequences were obtained for seven ATL cases and phylogenetic analysis of complete genomes revealed strong ethnic clustering: all Creole strains belonged to the Transcontinental subtype, while all Maroon strains belonged to the West African subtype. Moreover, HTLV-1 prevalence in the general population was measured among 1,078 Creoles tested in 1998, with a prevalence of 3.1%, markedly lower and occurring at older ages compared to previously published data for the Maroon population. Our findings highlight pronounced disparities in ATL epidemiology by ethnic group, and emphasize the need for targeted prevention, early diagnosis, and improved care in high-risk populations.

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Fichiers liés : afonso.pdf

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• Type de publi. : Rapport
• Date de publi. : 25/06/2025
• Auteurs : Rodolphe LeméeJean-François HumbertÉric AbadieZouher AmzilElisa BerdaletRonel BiréMarie-Yasmine Dechraoui BotteinLuc de HaroNicolas DelcourtValérie FessardJean‐philippe JaegCésar MatteiAnne OppligerAnne‐sophie PavauxEva TernonGilles BornertAnne TogolaJean BaronJean Luc BoudenneNicolas CimetiereBruno CoulombChristophe DagotSabine DenoozIsabelle DublineauFrédéric FederMatthieu FournierStéphane Garnaud-CorbelNathalie GarrecJohnny GasperiJulio GonçalvèsJean-Louis GonzalezOlivier HornerMichel JoyeuxJérôme LabanowskiSophie Lardy-FontanFrançoise LucasChristophe MechoukLaurent MoulinDamien MoulyFabienne PetitCatherine QuiblierPauline Rousseau-GueutinMarie-Pierre Sauvant-RochatMichèle TremblayBruno Le BizecMarie-Louise ScippoPierre-Marie BadotRachida ChekriChristine DemeilliersVirginie DesvignesErwan EngelGautier EppeAnne‐sophie FicheuxEric HoudeauEmilie LanceOlivier LaprévoteMichel LaurentieLudovic Le HegaratJean-Charles LeblancNicolas LoiseauDavid MakowskiFrancesca Romana ManciniEric MarchioniJean‐françois MasfaraudMathilde MunierIsabelle P. OswaldAnne PlatelYann SivryPaule VasseurEstelle Checlair-WesterbergNathalie ArnichEléonore NeyCarole CatastiniNicolas Loiseau
• Organismes : Laboratoire d'océanographie de Villefranche Institut d'écologie et des sciences de l'environnement de Paris Délégation Océan Indien Unité Physiologie et Toxines des Microalgues Toxiques et Nuisibles Institut national des sciences et techniques de la mer Laboratoire de sécurité des aliments, sites de Maisons-Alfort et de Boulogne-sur-Mer Ecology and Conservation Science for Sustainable Seas Hôpital Sainte-Marguerite [CHU - APHM] Centre antipoison et de toxicovigilance [CHU Toulouse] Laboratoire de Fougères - ANSES Ecole Nationale Vétérinaire de Toulouse MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Laboratoire de Génie des Procédés et Matériaux Laboratoire d'océanographie de Villefranche Service de Santé des Armées Bureau de Recherches Géologiques et Minières Eau de Paris Laboratoire Chimie de l'environnement Institut des Sciences Chimiques de Rennes Laboratoire Chimie de l'environnement Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Société wallonne des eaux Unité d'expertise des sites et des déchets radioactifs Centre de Coopération Internationale en Recherche Agronomique pour le Développement Morphodynamique Continentale et Côtière Université de Rouen Normandie Service anthropisation et fonctionnement des écosystèmes terrestres Centre Scientifique et Technique du Bâtiment Eau et Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Institut Français de Recherche pour l'Exploitation de la Mer Laboratoire National d’Hydraulique et Environnement École Pratique des Hautes Études Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Laboratoire d'hydrologie de Nancy Laboratoire Eau Environnement et Systèmes Urbains Ville de Lausanne Eau de Paris Santé Publique France, Occitanie [Toulouse, France] Morphodynamique Continentale et Côtière Muséum national d'Histoire naturelle École des Hautes Études en Santé Publique Université de Rennes Département des sciences en santé environnementale Institut Pascal Retraité Laboratoire d'étude des Résidus et Contaminants dans les Aliments Fundamental and Applied Research for Animals & Health Laboratoire Chrono-environnement (UMR 6249) Éléments Traces Métalliques et Minéraux Environnement et Prévention en Santé des Populations Centre Scientifique et Technique du Bâtiment Qualité des Produits Animaux Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire sur les interactions Epithéliums Neurones ToxAlim Stress Environnementaux et BIOsurveillance des milieux aquatiques Cibles Thérapeutiques et conception de médicaments Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail ToxAlim Mathématiques et Informatique Appliquées Centre de recherche en épidémiologie et santé des populations Institut Pluridisciplinaire Hubert Curien Laboratoire Interdisciplinaire des Environnements Continentaux MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers Biosynthèse & Toxicité des Mycotoxines Laboratoire de toxicologie génétique [Lille] Laboratoire de géochimie des Eaux Laboratoire Interdisciplinaire des Environnements Continentaux Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Toxicologie Intégrative & Métabolisme

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Résumé : In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several hundred cases of intoxication among holidaymakers and residents. The main route of human exposure is inhalation of aerosols, although it is not yet known whether the agents responsible for poisoning are Ostreopsis cells, cell debris, known toxins produced by Ostreopsis, or other as yet unidentified compounds. Other routes of exposure (dermal contact, eye contact, ingestion of contaminated water or seafood) are also possible. Poisoning is manifested through various signs and symptoms, occurring within 48 hours of exposure (Neurosensory and neurological, respiratory, dermal and digestive). This document presents the opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), established from the work of its WATER and ERCA Expert Committees. ANSES received a request from the Directorate General for Health (DGS) and the Directorate General for Food (DGAL) to update knowledge about Ostreopsis that had been reported in the Agency's opinions from 2007 and 2008 (ANSES, 2007 and 2008), and draw up specific recommendations for managing Ostreopsis proliferation on the Basque coast. The literature review conducted as part of this expert appraisal revealed that knowledge about the genus Ostreopsis (diversity, biology, ecology, toxins produced) is still too fragmentary to characterise the hazard and risk to human health. Nevertheless to help local authorities affected by Ostreopsis blooms, Agency proposes a surveillance and quality monitoring strategy based on collaboration between site managers and the regional health agencies (ARSs), applicable to sites currently subject to bathing water quality monitoring and water sports sites that meet the conditions below.

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Fichiers liés : Food Risk Assess Europe - 2025 - Lemée - Opinion of the French Agency for Food Environmental and Occupational Health .pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/06/2025
• Auteurs : Alain LécureuilMassimiliano CorsoStéphanie BoutetSophie Le GallRegina NiñolesJose GadeaPhilippe GuercheSophie Jasinski
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Unité de recherche sur les Biopolymères, Interactions Assemblages BIBS - Plateforme Bioressources : Imagerie, Biochimie & Structure Instituto de Biologia Molecular y Celular de Plantas Instituto de Biologia Molecular y Celular de Plantas Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans The Plant Journal le 26/10/2020

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Résumé : SUMMARY Brassicaceae species mainly accumulate oil and protein in their seeds, which are essential to human life as a source of food, but also as animal feed and resources for green chemistry. To date, Brassicaceae crops such as rapeseed have been selected mainly for their oil content. However, there is a growing interest in their seed protein content. A strong negative correlation between oil and protein content makes it difficult to increase both compounds simultaneously. In this study, an Arabidopsis thaliana homozygous EMS mutant library was screened for seed oil and protein content by near‐infrared spectroscopy with the aim of identifying mutants with impaired oil/protein correlation. The mutant most affected in this correlation was found to be in the TRANSPARENT TESTA7 gene, which is involved in the flavonoid biosynthetic pathway. Analysis of different mutants in the flavonoid pathway revealed that the tt7 mutants were the only ones to show such a significant reduction in seed oil content, highlighting a phenotype never described before for the tt7 mutants and suggesting a specific role for TT7 in the interplay between the oil and flavonoid biosynthetic pathways. Untargeted metabolomic analysis allowed the identification of metabolic features that are highly accumulated and specific to tt7 seeds compared to the other genotypes and genetic analysis established that the accumulation of kaempferol‐3‐O‐rhamnoside seems to be responsible for the seed oil reduction in tt7 mutants.

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Fichiers liés : 2025_Lécureuil_The Plant Journal.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/06/2025
• Auteurs : David-Tomline MichelLaurent BizetThibault BoulantMatthieu VallaAmaury Capmas-PernetNicolas CézardFrédéric DambrevilleFlorence de La BarrièreYann FerrecJosué GauthierOlivier GazzanoDidier GoularJulien HouyLaurent LombardJean-François MariscalChristian MussoPerrault PhilippeChristophe PlanchatP. PichonJonathan PouillaudeNicolas Rouanet
• Organismes : DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université de Toulouse [Toulouse] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Châtillon] DOTA, ONERA, Université Paris Saclay [Palaiseau] ATMOSPHERE - LATMOS DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] ATMOSPHERE - LATMOS

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Résumé : On-board 3D wind measurement at all altitudes has numerous aeronautical applications (Gust Load Alleviation, HAPS, etc.) or space (wind measurement with Aeolus, calibration/validation of Aeolus data). This 3D wind measurement is particularly interesting in turbulent wind for several applications such as weather and climate forecasting, planning and safety of aircraft during their flight, transport of aerosols and pollution, monitoring of weather conditions in case disasters, wind power generation, forest fires and volcanic plume movement. (see session A.01.09). The instrument developed for this type of measurement is the direct detection UV lidar which sends a laser pulse into the atmosphere and determines, with a spectral analyzer, the wind projected on the axis of the lidar from the Doppler shift induced by the particles (low altitude) and molecules (high altitudes) of the atmosphere. To measure the radial wind, the quad Mach-Zehnder (QMZ) interferometer is, to our knowledge, the best compromise between precision and robustness [D. Bruneau and J. Pelon, ATM. Measures. Technology. 14 4375-2021 (2021)]. Additionally, such an analyzer can also be used to determine particle backscatter coefficients, extinction coefficient and can be extended with a dedicated channel for aerosol and cloud polarization analysis. This is why, at ONERA, we are developing an all-altitude wind lidar solution based on a QMZ analyzer. The 3D wind is then reconstructed by addressing the lidar axis in several directions and using an algorithm (C. Musso et al., session A.01.09) to recover the 3D wind components from the measured wind projections. This instrument includes several solutions to obtain a vibration-robust version of the different lidar components (analyzer, laser, transmission/reception, scanning system and overall instrument). The QMZ interferometer is a two-wave interferometer that provides four signals of the two-wave interference pattern, in phase quadrature, used to determine the frequency shift of backscattered light energy and derive the radial wind speed. The advantages of the QMZ interferometer, compared to other solutions, are as follows: (1) it is not sensitive to the frequency drift of the laser source, (2) it is not sensitive to the shape of the backscattered spectrum, (3) it gives a small statistical error equal to 2.35 (εvr)ISA where (εvr)ISA is the error obtained for an ideal analyzer, (4) it can include a field compensation design which allows a wide angle of incident field and facilitates their adaptation with an extended wide beam system, and (5) it uses mono-detectors which do not truncate the collected signal (compared to marginal imaging systems). In order to be on-board, two architectures of interferometers robust to vibrations are developed at ONERA: (1) a first based on commercial components and (2) a second monolithic, made up of adhesion of all the optical components. The first version is cheaper and easier to study in depth while the second version is more solid. To obtain architectures insensitive to angular misalignment, both are composed of a single separator and two retroreflective optics. An innovative calibration procedure was developed to determine the exact contrast and phase difference between the four outputs based on the Lissajou curves. The two architectures, their simulated performances and the first experimental results will be presented. In addition to the spectral analyzer, the wind lidar includes several components that must be compacted and reinforced to be able to be used on aircraft. Typically used solid-state UV lasers are very sensitive to vibrations (especially the laser cavity) and their use on board generally requires using a lot of metal to make it insensitive to vibrations, leading to very heavy and expensive solutions. To resolve this problem, we are developing a solution based on a fiber laser which has the advantage of being, in the long term, lighter and more robust to vibrations. The architecture of the system used to address/focus the laser in the probed region and collect the backscattered light from this region is generally designed in a bistatic configuration where the optical axes of the two systems are determined with different optics. However, the transmission and reception must have the same axis, which poses a problem in vibration conditions, for long distance measurements, due to the large lever arm of the two systems. To avoid this problem, we have developed a new monostatic configuration close to that commonly used for heterodyne lidars. To address the beam in different directions, we design a static system comprising several duplicated monostatic transmit/receive instruments. A time multiplexing method is developed to use a shared spectral analyzer to process all axes. The addressed angles were optimized using the 3D wind reconstruction algorithm presented in (C. Musso et al., session A.01.09). The design of all these components will be presented. The project 101101974 – UP Wing is supported by the Clean Aviation Joint Undertaking and its members. Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or Clean Aviation Joint Undertaking. Neither the European Union nor the granting authority can be held responsible for them

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/06/2025
• Auteurs : Najwa SharafGuillaume P. MorinJordi PratsGabriel OrabonaNathalie ReynaudThierry TormosOlivia DesgueJean-Philippe JennyPierre-Alain DanisRosalie Bruel
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Pôle Écla - écosystèmes lacustres Magellium Segula Technologies Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Pôle Écla - écosystèmes lacustres Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Pôle Écla - écosystèmes lacustres Pôle Écla - écosystèmes lacustres Service fonctionnement, préservation et restauration des écosystèmes aquatiques continentaux et marins Pôle Écla - écosystèmes lacustres Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Pôle Écla - écosystèmes lacustres Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Pôle Écla - écosystèmes lacustres Service fonctionnement, préservation et restauration des écosystèmes aquatiques continentaux et marins Pôle Écla - écosystèmes lacustres Service fonctionnement, préservation et restauration des écosystèmes aquatiques continentaux et marins

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• Type de publi. : Article dans une revue
• Date de publi. : 23/06/2025
• Auteurs : Federica MulèLuca PandolfiAnne-Lise CharruaultJean-Yves CrochetJérôme IvorraFabrice LihoreauLaurent MarivauxMehdi MouanaFélix NesmeCéline RobinetPhilippe MunchPierre-Olivier Antoine
• Organismes : Institut des Sciences de l'Evolution de Montpellier University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier SPN Pézenas Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Université de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Géosciences Montpellier Institut des Sciences de l'Evolution de Montpellier Université de Montpellier
• Publié dans Palaeovertebrata le 01/01/2003

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Résumé : Numerous "Quaternary" large-mammal fossils have been collected since the 1830s along the Le Riège stream, near Pézenas (Southern France). More than 120 specimens are stored in the collections of the Université de Montpellier (UM) under the name "Le Riège". A major operation aiming at relocating the palaeontological collections of the University has made it possible to group together all the specimens of interest and launch their systematic revision for the first time. The fossils belong to the Reboul (1839; 51 samples) and de Christol (1865; 18 samples) Collections and 17 samples compose the Crochet & Ivorra Collection (1998). The remaining 38 samples have no mention about the exact time and location of their finding. We provide a critical inventory with literal transcription of inscriptions on specimens and historical labels. This revision confirms the presence of two distinct faunal assemblages under the name of "Le Riège": Saint-Palais (Early Pliocene, MN14-15) and Le Riège sensu stricto (late Early Pleistocene, most likely MNQ19). The former assemblage, with coastal affinities, is composed of the ruminants Alephis sp. and Procapreolus cf. pyrenaicus, the rhinocerotid Pliorhinus megarhinus, the gomphotheriid Anancus arvernensis and marine mammals, all emblematic taxa for the Early Pliocene of Montpellier and Perpignan. The latter assemblage documents a late Early Pleistocene fluvio-volcanic sequence, yielding the bovid Bison (Eobison) spp., the cervid Eucladoceros cf. giulii, the hippopotamid Hippopotamus antiquus, the rhinocerotid Stephanorhinus etruscus, the equid Equus cf. altidens, and the elephantid Mammuthus cf. meridionalis, plus a few specimens of uncertain taxonomic affinities. This revision underscores the interest of revisiting historical collections and further provides a starting point for future research.

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Fichiers liés : Mulé-et-al_2025_Palaeovertebrata_Quaternary-faunas-Le-Riège-St-Palais.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/06/2025
• Auteurs : Jeanne GoulinThomas BriglyRony SfeirPatrick Desbordes de CepoyArnaud BonnardVéronique RousseauThomas GelasAudrey GuinotEdouard HabonimanaPascale MicheauAline RankeIsabelle Talon LacreuseSabine IrtanThierry LamireauRabattu PyFrédéric ElbazN. KalfaNicoleta PanaitVirginie FouquetHubert LardyAurélien ScalabrePhilippe BuissonMarc MargaryanFrédéric AuberCéline GrososCorinne BorderonCécilia TölgFrançois BastardFrançoise TroussierFrédéric GottrandFrançoise Schmitt
• Organismes : Centre Hospitalier Universitaire d'Angers Centre Hospitalier de Laval Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire d'Angers Hôpital Robert Debré Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Lyon Sud [CHU - HCL] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de chirurgie pédiatrique [CHU Strasbourg] CHU Trousseau [APHP] Hôpital Pellegrin Service de chirurgie pédiatrique [CHU Grenoble] CHU Rouen Département Chirurgie Pédiatrique [CHRU Montpellier] Chirurgie orthopédique et pédiatrique [Hôpital de la Timone - APHM] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] CHU Trousseau [Tours] Service de Chirurgie pédiatrique [CHU Saint-Etienne] CHU Amiens-Picardie Centre Hospitalier Le Mans (CH Le Mans) Service de chirurgie pédiatrique [CHU Besançon] CHU Limoges CHU Clermont-Ferrand Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire d'Angers
• Publié dans Journal of Pediatric Surgery le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 20/06/2025
• Auteurs : Anouchka ModestoSophie GibertCaroline DelmasDavid TougeronAmaury PaumierAlexandre TaillezSamuel Le SourdDelphine Argo LeignelPhilippe RonchinAriane Darut JouveVéronique VendrelyOlivier RiouJérôme Martin-BabauThomas LeroyLaurent QuéroNaïma HanounPierre CordelierVeronica PezzellaJean-Pierre DelordRosine GuimbaudElizabeth Cohen-Jonathan MoyalCatherine Seva
• Organismes : Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Centre d'Etudes et Recherches en Thermique, Environnement et Systèmes [Créteil] Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Oncopole Claudius Regaud Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Centre de Recherches en Cancérologie de Toulouse
• Publié dans International Journal of Cancer le 30/10/2020

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Résumé : Abstract Locally advanced esophageal carcinoma remains of poor prognosis correlated with tumor stage. Albeit liquid biopsy approach offers promising results to monitor high‐risk patients in various solid tumors, the lack of specific mutation in esophageal tumor, limits the detection of circulating tumor DNA (ctDNA) with high sensitivity using sequencing‐based methods. In this study, we employed a highly sensitive technology of fragmentome assay, previously validated to measure concentration and size distribution of cell‐free DNA (cfDNA), to analyze plasma samples from 77 patients with esophageal carcinoma, compared to 15 healthy controls. Total cfDNA concentration was significantly higher in patients than in healthy donors (15.03 ± 1.37 vs. 5.87 ± 0.85 pg/μL, p < .0001). The difference remained significant regardless of tumor histology, location, stage, or nodal involvement and was independent from age or gender. Additionally, we observed a significant reduction in patients fragment length compared to healthy donors. The area under curve from receiver operating characteristic (ROC) of total cfDNA concentration in patients versus healthy donors was 0.86 ( p ‐value <.0001). The threshold of 7.5 pg/μL yielded a sensitivity of 81% and a specificity of 80%. This prospective study demonstrated that blood samples from patients exhibit a greater global concentration of smaller fragments compared to healthy controls. These findings support further longitudinal evaluation to determine the predictive and prognostic value of cfDNA in locally advanced unresectable esophageal carcinoma.

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• Type de publi. : Article dans une revue
• Date de publi. : 18/06/2025
• Auteurs : Aude NicolasRichard ShervaBenjamin Grenier-BoleyYoontae KimMasataka KikuchiJigyasha TimsinaItziar de RojasMaria Carolina DalmassoXiaopu ZhouYann Le GuenCarlos Arboleda-BustosMaria Aparecida Camargos BicalhoMaëlenn GuerchetSven van der LeeMonica GossAtahualpa CastilloCéline BellenguezFahri KüçükaliClaudia SatizabalBernard FongangQiong YangOliver PetersAnja SchneiderMartin DichgansDan RujescuNorbert ScherbaumJürgen DeckertSteffi Riedel-HellerLucrezia HausnerLaura Molina-PorcelEmrah DüzelTimo GrimmerJens WiltfangStefanie Heilmann-HeimbachSusanne MoebusThomas TegosNikolaos ScarmeasOriol Dols-IcardoFermin MorenoJordi Pérez-TurMaría BullidoPau PastorRaquel Sánchez-ValleVictoria ÁlvarezHan CaoNancy IpAmy FuFanny IpNatividad OlivarCarolina MuchnikCarolina CuestaLorenzo CampanelliPatricia SolisDaniel Gustavo PolitisSilvia KochenLuis Ignacio BruscoMercè BoadaPablo García-GonzálezRaquel PuertaPablo MirLuis RealGerard Piñol-RipollJose María García-AlbercaJose Luís RoyoEloy Rodriguez-RodriguezHilkka SoininenSami HeikkinenAlexandre de MendonçaShima MehrabianLatchezar TraykovJakub HortMartin VyhnalekKatrine Laura RasmussenJesper Qvist ThomassenYolande PijnenburgHenne HolstegeJohn van SwietenHarro SeelaarJurgen ClaassenWillemijn JansenInez RamakersFrans VerheyAad van der LugtPhilip ScheltensJenny Ortega-RojasAna Gabriela Concha MeraMaria MahechaRodrigo PardoGonzalo ArboledaShahram BahramiVera FominykhGeir SelbækCaroline GraffGoran PapenbergVilmantas GiedraitisAnne BolandJean‐françois DeleuzeLuiz Armando de MarcoEdgar Nunes de MoraesBernardo de Mattos VianaMarco Túlio Gualberto CintraTeresa Juarez-CedilloAnthony GriswoldTatiana ForundJonathan HainesLindsay FarrerAnita DestefanoEllen WijsmanRichard MayeuxMargaret Pericak-VanceBrian KunkleAlison GoateGerard SchellenbergBadri VardarajanLi-San WangYuk Yee LeungClifton DalgardGaël NicolasDavid WallonCarole DufouilFlorence PasquierOlivier HanonStéphanie DebetteEdna GrünblattJulius PoppBárbara AngelSergio GlogerMaria Victoria ChaconRafael AranguizPaulina OrellanaAndrea SlachevskyChristian Gonzalez-BillaultCecilia AlbalaPatricio FuentesPerminder SachdevKaren MatherRichard HaugerVictoria MerrittMatthew PanizzonRui ZhangJ. Michael GazianoRoberta GhidoniDaniela GalimbertiBeatrice ArosioPatrizia MecocciVincenzo SolfrizziLucilla ParnettiAlessio SquassinaLucio TremolizzoBarbara BorroniBenedetta NacmiasPaolo CaffarraDavide SeripaInnocenzo RaineroAntonio DanieleFabrizio PirasSonia Moreno-GrauNajaf AminPeter HolmansLuca KleineidamDag AarslandPablo Garcia-GonzalezCarla AbdelnourEmilio Alarcón-MartínDaniel AlcoleaMontserrat AlegretIgnacio AlvarezNicola ArmstrongTsolaki AnthoulaIldebrando AppollonioMarina ArcaroSilvana ArchettiAlfonso Arias PastorLavinia AthanasiuHenri BaillyNerisa BanajMiquel BaqueroAna Belén PastorSonia BelliniClaudine BerrCéline BesseValentina BessiGiuliano BinettiAlessandra BizarroRafael BlesaSilvia BoschiPaola BossùGeir BråthenCatherine BresnerHenry BrodatyKeeley BrookesDolores Buiza-RuedaKatharina BûrgerVanessa BurholtMiguel CaleroGeneviève CheneÁngel CarracedoRoberta CecchettiLaura Cervera-CarlesCamille CharbonnierCaterina ChillottiSimona CicconeJordi ClarimonChristopher ClarkElisa ContiAnaïs Corma-GómezGuido Maria GiuffrèCarlo CustoderoDelphine DaianEfthimios DardiotisPeter Paul de DeynTeodoro del SerNicola DenningJanine Diehl-SchmidMónica Diez-FairenPaolo Dionigi RossiSrdjan DjurovicEmmanuelle DuronSebastiaan EngelborghsAna EspinosaMichael EwersTagliavini FabrizioSune Fallgaard NielsenLucia FarottiChiara FenoglioMarta Fernández-FuertesCatarina FerreiraEvelyn FerriBertrand FinPeter FischerTormod FladbyKlaus FließbachJuan ForteaTatiana ForoudSilvia FostinelliNick FoxEmlio Franco-MacíasAna Frank-GarcíaLutz FroelichJose Maria García-AlbercaSebastian Garcia-MadronaGuillermo Garcia-RibasIna GieglingGiaccone GiorgioOliver GoldhardtAntonio González-PérezGiulia GrandeEmma GreenTamar Guetta-BaranesAnnakaisa HaapasaloGeorgios HadjigeorgiouHarald HampelJohn HardyAnnette HartmannJanet HarwoodSeppo HelisalmiMichael HenekaIsabel HernándezMartin HerrmannPer HoffmannClive HolmesRaquel Huerto VilasMarc HulsmanGeert Jan BiesselsCharlotte JohanssonLena KilanderAnne Kinhult StåhlbomMiia KivipeltoAnne KoivistoJohannes KornhuberMary KosmidisCarmen LageErika LaukkaAlessandra LauriaJenni LehtisaloOndrej LerchAlberto LleóAdolfo López-de MunainSeth LoveMalin LöwemarkLauren LuckcuckJuan MacíasCatherine MacleodWolfgang MaierFrancesca MangialascheMarco SpallazziMarta MarquiéRachel MarshallAngel Martín MontesCarmen Martínez RodríguezSimon MeadMiguel MedinaAlun MeggySilvia MendozaManuel Menéndez-GonzálezMerel MolLaura MontrrealKevin MorganMarkus MöthenTiia NganduBørge NordestgaardRobert OlasoAdelina OrellanaMichela OrsiniGemma OrtegaAlessandro PadovaniAlba Pérez-CordónPierre PericardJuan PinedaClaudia PisanuThomas PolakDanielle PosthumaJosef PrillerOlivier QuenezInés QuintelaAlberto RábanoMarcel ReindersPeter RiedererNatalia RobertoArvid RongveIrene Rosas AllendeMaitée Rosende-RocaJose Luis RoyoElisa RubinoMaría Eugenia SáezParaskevi SakkaIngvild SaltvedtÁngela SanabriaMaría Bernal Sánchez-ArjonaFlorentino Sanchez-GarciaPascual Sánchez-JuanSigrid SandoMichela ScamosciElio ScarpiniMartin SchererMatthias SchmidJonathan SchottAlexey ShadrinOlivia SkrobotAlina SolomonSandro SorbiOscar Sotolongo-GrauAnnika SpottkeEystein StordalJuan Pablo TartanLluís TárragaNiccolo TesíAnbupalam ThalamuthuTegos ThomasAnne Tybjærg-HansenAndre UitterlindenAbbe UllgrenIngun UlsteinSergi ValeroChristine van BroeckhovenJasper van DongenRik VandenbergheJean-Sébastien VidalJonathan VogelgsangMichael WagnerLeonie WeinholdGill WindleBob WoodsMary YannakouliaMiren ZulaicaHampton LeonardJennifer YokoyamaMike NallsAkinori MiyashitaNorikazu HaraKouichi OzakiShumpei NiidaJulie WilliamsCarlo MasulloPhillippe AmouyelPierre-Marie PreuxPascal MbelessoBébène BandzouziAndrew J SaykinFrank JessenPatrick Gavin KehoeCornelia van DuijnNesrine Ben SalemRuth Frikke-SchmidtLotfi CherniMichael GreiciusMagda TsolakiPascual Sánchez-JuanMarco Aurélio Romano SilvaTenielle PorterSimon LawsKristel SleegersMartin IngelssonJean-François DartiguesSudha SeshadriGiacomina RossiLaura MorelliMikko HiltunenRebecca SimsWiesje M van der FlierOle AndreassenHumberto ArboledaCarlos CruchagaValentina Escott-PriceAgustín RuizKun Ho LeeTakeshi IkeuchiAlfredo RamirezJungsoo GimMark LogueJean-Charles Lambert
• Organismes : École du Louvre Centre de recherches interdisciplinaires en histoire, histoire de l'art et musicologie [UR 15507] Virginia Commonwealth University Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Osaka University [Osaka] Epidémiologie des Maladies Chroniques en zone tropicale Laboratory of Chronic and Neurological Diseases Epidemiology Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre d'Etude du Polymorphisme Humain Centre de référence, d’innovation, d’expertise et de transfert Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Nature Genetics le 29/10/2020

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Résumé : A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.

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Fichiers liés : s41588-025-02227-w.pdf

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