Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 04/02/2026
• Auteurs : Daisy BertrandJean PhilippePierre-Yves Léo
• Organismes : Centre d'Études et de Recherche en Gestion d'Aix-Marseille Aix-Marseille Université CERGAM, Faculté d'Économie et Gestion Aix-en-Provence Aix-Marseille Université CERGAM, Faculté d'Économie et Gestion Aix-en-Provence
• Publié dans European Review of Service Economics and Management le 23/10/2020

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Résumé : Consumer interest in peer-to-peer (P2P) accommodation has grown exponentially in recent years. It is therefore essential to understand why customers prefer these options over traditional hotels. Our research examines the service experience of consumers renting P2P accommodation via sharing platforms and analyzes the impact of various service attributes on repurchase intention. A survey of 240 French home-sharing guests was analyzed using PLS-SEM. Results indicate that trust in the platform, well-being, and satisfaction directly influence repurchase intention, while service quality, financial benefits, and social benefits have an indirect impact through satisfaction. We propose a hierarchy of service attributes that shape consumers’ intention to repurchase P2P services and offer practical implications for Airbnb stakeholders seeking to enhance the overall value of the service experience.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 04/02/2026
• Auteurs : Corentin DancetteJulien KhlautAntoine SaportaHelene PhilippeElodie FerreresBaptiste CallardThéo DanielouLéo AlbergeLéo MachadoDaniel TordjmanJulie DupuisKorentin Le FlochJean Du TerrailMariam MoshiriLaurent DercleTom BoekenJules GregoryMaxime RonotFrançois LegouPascal RouxMarc SapovalPierre ManceronPaul Hérent
• Organismes : Raidium Raidium Raidium Raidium Raidium Raidium Raidium Raidium Raidium Raidium Raidium Raidium Raidium

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Résumé : AI-assisted radiological interpretation is based on predominantly narrow, single-task models. This approach is impractical for covering the vast spectrum of imaging modalities, diseases, and radiological findings. Foundation models (FMs) hold the promise of broad generalization across modalities and in low-data settings. However, this potential has remained largely unrealized in radiology. We introduce Curia, a foundation model trained on the entire cross-sectional imaging output of a major hospital over several years-which to our knowledge is the largest such corpus of real-world data-encompassing 150,000 exams (130 TB). On a newly curated 19-task external validation benchmark, Curia accurately identifies organs, detects conditions like brain hemorrhages and myocardial infarctions, and predicts outcomes in tumor staging. Curia meets or surpasses the performance of radiologists and recent foundation models, and exhibits clinically significant emergent properties in cross-modality, and low-data regimes. To accelerate progress, we release our base model's weights at https://huggingface.co/raidium/curia.

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Fichiers liés : 2509.06830v1 (4).pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 03/02/2026
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadArchana SharmaLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekHenriette Aarup PetersenSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereFrancisco Gameiro CasalinhoAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangHeng YangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong 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HiroskyMaria JoseAlexander LedovskoyCristina MantillaChristopher NeuClara Ramón ÁlvarezZhenyu WuSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaShivani LomteRichard LovelessAbhishikth MallampalliAbdollah MohammadiSusmita MondalTrevor NelsonGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiRuslan ChistovMikhail DanilovTatyana DimovaAlexander ErshovSergei GninenkoIlya GorbunovAndrey GribushinAlexey KamenevVladimir KarjavineMikhail KirsanovVyacheslav KlyukhinOlga KodolovaVladimir KorenkovIurii KorsakovAleksei KozyrevNikolai KrasnikovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoSergey PolikarpovOlesia RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenKirill SlizhevskiyVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinAnatoli ZarubinIlia ZhizhinLev DudkoVictor KimVictor MurzinVadim OreshkinDmitry SosnovEdouard BoosViacheslav BunichevMikhail DubininViktor SavrinAlexander Snigirev
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon

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Résumé : In the physics program of the CMS experiment during the CERN LHC Run 3, which started in 2022, the long-lived particle triggers have been improved and extended to expand the scope of the corresponding searches. These dedicated triggers and their performance are described in this paper, using several theoretical benchmark models that extend the standard model of particle physics. The results are based on proton-proton collision data collected with the CMS detector during 2022$-$2024 at a center-of-mass energy of 13.6 TeV, corresponding to integrated luminosities of up to 123 fb$^{-1}$.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Justyna JońcaUrszula MillerJarosław SzrekArtur MuraszkowskiAdalbert ArsenIzabela SówkaKatia FajerwergMyrtil L KahnPhilippe MeniniPierre Fau
• Organismes : Wroclaw University of Science and Technology = Politechnika Wroclawska [Wrocław] Wroclaw University of Science and Technology = Politechnika Wroclawska [Wrocław] Wroclaw University of Science and Technology = Politechnika Wroclawska [Wrocław] Wroclaw University of Science and Technology = Politechnika Wroclawska [Wrocław] calval.pl Wroclaw University of Science and Technology = Politechnika Wroclawska [Wrocław] Laboratoire de chimie de coordination Laboratoire de chimie de coordination Équipe MICrosystèmes d'Analyse Nanostructures et chimie organométallique (LPCNO)
• Publié dans Sensors and Actuators B: Chemical le 30/10/2020

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Résumé : We present the development and application of novel metal oxide gas sensors derived from organometallic and ion-exchange synthesis routes, integrated into an electronic nose platform for the detection of hydrogen sulfide (H₂S) and odorous compounds. The CuO, SnO₂, and WO₃ nanoparticles were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). These nanomaterials were deposited as single and double-layer structures forming engineered p-n and n-n heterojunctions. The sensors were evaluated in a wide H₂S concentration range (5 ppb to 50 ppm) under controlled humidity and temperature conditions. Double-layer configurations exhibited significantly enhanced sensitivity, selectivity, and stability compared to commercial MOS sensors. Selected sensors were integrated into a custom-built gas sensing array and used to construct an e-nose system. The system was trained using dynamic olfactometry and applied for odor quantification in real samples from a Municipal Solid Waste Treatment Plant (MSWTP). The e-nose achieved high accuracy in estimating odor concentrations and deodorization efficiency in two full-scale biofilters, outperforming commercial sensor systems. This study presents a complete sensor-to-application workflow, combining nanomaterial design, sensor engineering, statistical modelling, and real-world environmental monitoring. It highlights the potential of organometallic-derived MOS sensors as key components in advanced gas sensing platforms for reliable odor detection in complex industrial environments.

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Fichiers liés : Jonca, Organometallic-derived metal oxide sensors for H₂S detection, 2026.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Boris BarrovecchioGwenhael ColinLaurent ArgaudIsabelle DesmeullesPierre BaillyNicholas SedillotHelene NougueNicolas PichonShidasp SiamiGaetan PlantefeveGuillaume SchnellMaleka SchenckPierrick CronierSebastien PerbetAnais CurtiaudMichael PiagnerelliMehran MonchiNicolas DeyeJuliette AudibertCharles CerfPhilippe AriesGuillaume ThieryVincent DasS. SilvaMarc SimonGwenaelle JacqFrederic JacobsCedric DaubinVirginie LemialePascal BeuretGuillaume Gele-DecaudinJean-Pierre QuenotJean-Baptiste LascarrouOlivier LesieurChristophe GuittonStephane Legriel
• Organismes : Research on Healthcare Performance Centre Hospitalier Universitaire de Toulouse Toulouse NeuroImaging Center Institut National de la Santé et de la Recherche Médicale Université de Toulouse
• Publié dans Resuscitation le 28/10/2020

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Résumé : Brain death after hanging-induced cardiac arrest is a fatal complication about which few data are available. We aimed at identifying the early predictors of progression to brain death in patients with hanging-induced cardiac arrest.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Frederic HabiyaremyeCamille ThenotPierre SallotDaniel MonceauJean-Philippe P Monchoux
• Organismes : Centre d'élaboration de matériaux et d'études structurales Centre d'élaboration de matériaux et d'études structurales Endommagement et durabilité [Institut Pprime] Centre interuniversitaire de recherche et d'ingénierie des matériaux Physique de la Plasticité et Métallurgie
• Publié dans Intermetallics le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Anthony L’hostellierCharles KouanfackCorine ChazallonSandra Wagner-CardosoSerge Paul EholieNeiva BanzeGuttiga HalueJacqueline CapeauConstance DelaugerreRaoul MohFabrice BonnetLiliane Mfeukeu KuateAntoine JaquetHugo PerazzoCharlotte BernardJean-Philippe BastardLauriane GoldwirtPaul VilquinPedroso Pedro NhassengoMargot LavaléeNicolas MinvielleP J DoddOlivier MarcyJean-Michel MolinaBeatriz GrinsztejnPierre O Sellier
• Organismes : Bordeaux population health Global Health in the Global South Université de Dschang [Cameroun] = University of Dschang [Cameroon] Bordeaux population health Global Health in the Global South Fundação Oswaldo Cruz / Oswaldo Cruz Foundation Centre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] Instituto Nacional de Saude [Maputo, Mozambique] University of Phayao Centre de Recherche Saint-Antoine Assistance publique - Hôpitaux de Paris Programme PAC-CI Bordeaux population health Global Health in the Global South Hôpital Saint-André [Bordeaux] Université de Yaoundé I = University of Yaoundé 1 Bordeaux population health Global Health in the Global South Fundação Oswaldo Cruz / Oswaldo Cruz Foundation Bordeaux population health Global Health in the Global South Assistance publique - Hôpitaux de Paris Institut Mondor de Recherche Biomédicale AP-HP - Hôpital Saint-Louis [Paris] Université Paris Cité AP-HP - Hôpital Saint-Louis [Paris] Université Paris Cité Instituto Nacional de Saude [Maputo, Mozambique] Agence Nationale de Recherches sur le Sida et les Hépatites Virales Agence Nationale de Recherches sur le Sida et les Hépatites Virales University of Sheffield [Sheffield] Bordeaux population health Global Health in the Global South AP-HP - Hôpital Saint-Louis [Paris] AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Université Paris Cité Fundação Oswaldo Cruz / Oswaldo Cruz Foundation AP-HP - Hôpital Saint-Louis [Paris] AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Université Paris Cité
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction: Increasing evidence suggests that dolutegravir (DTG), endorsed by the WHO since 2018 for first-line antiretroviral therapy (ART), is associated with significant weight gain and potentially also with cardiometabolic disorders. In an effort to expand therapeutic options for people living with HIV (PLHIV), the EvaLuating the non-inferiority of DORAvirine vs DOlutegravir trial aims to compare the virologic efficacy of doravirine (DOR) and DTG-based regimens and to assess their safety, including a focus on cardiometabolic effects. Methods and analysis: This is an international, phase III, multicentre, open-label, non-inferiority, randomised trial that will enrol 610 ART-naïve PLHIV (HIV RNA≥1000 copies/mL at screening) across six countries (Brazil, Cameroon, France, Côte d'Ivoire, Mozambique and Thailand) spanning four continents. Key inclusion criteria include age ≥18 years, confirmed HIV-1 infection with plasma RNA levels ≥1000 copies/mL, indication for ART initiation and no prior ART exposure. Participants will be randomised in a 1:1 ratio to receive either DOR 100 mg once daily in combination with tenofovir disoproxil fumarate (TDF) (300 mg daily) plus lamivudine (3TC) (300 mg daily) or DTG (50 mg daily) in combination with TDF (300 mg once daily) plus either emtricitabine (FTC) (200 mg daily) or 3TC (300 mg daily). Randomisation will be stratified by screening HIV-1 RNA load (≤100 000 or >100 000 copies/mL) and by country. The primary outcome is virological efficacy, defined as the proportion of participants achieving HIV-1 RNA <50 copies/mL at week 48 on the assigned treatment (FDA Snapshot algorithm). Secondary outcomes include cardiometabolic safety endpoints (ie, weight gain, insulin resistance, hypertension, diabetes, waist and hip circumferences, waist-to-hip ratio, fasting glycaemia, insulin and fasting serum lipids), along with mental health, quality of life, virological and immunological parameters. Final data collection is expected by July 2028. Ethics and dissemination: Primary outcome results (week 48) are expected in early 2028. The project was submitted to and approved by national ethics committees and pharmaceutical regulatory authorities in all participating countries: Brazil (CEP INI FIOCRUZ (21.040-900)/CEP HGNI (26.030-380)); Cameroon (CNERSH (2024/09/1717/CE/CNERSH/SP)/Ministry of Public Health (D30-1464/AAR/MINSANTE/SG/DROS/CRC); Côte d'Ivoire: (CNESVS (0018224/MSHPCMU/CNESVS-km)/AIRP (1329/AIRP/DISMP/Om/kbaag); France (CTIS CPP/ANSM (2023-508626-10-00)); Mozambique (CNBS (20/CNBS/25)/ANARME (4635/380/ANARME)); Thailand: (IHRP (08/1944)/Thai FDA: ongoing on 19 January 2026). The trial received authorisation from the French National Commission for Data Protection and Liberties (CNIL) under approval number 924 302. Written informed consent is obtained from all participants prior to any study-specific procedures and trial enrolment, in accordance with the Declaration of Helsinki and applicable national regulations. Study findings will be disseminated through publication in peer-reviewed journals and presentations at national and international scientific conferences. Results will also be communicated to policymakers, healthcare professionals, community stakeholders and study participants through appropriate dissemination activities, including policy briefs, stakeholder meetings and lay summaries on dedicated and easily accessible platforms.

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Fichiers liés : bmjopen-16-2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Rémi LatourNonhlanhla MkhizeSégolène DebiesseSashkia BallaMqondisi TshabalalaFrances AyresZanele MakhadoPriscilla BiswasLogashvari NaidooStefania DispinseriTrisha RamrajNicolas NagotLucio GamaAmeena GogaGabriella ScarlattiYoann CazaubonPhilippe Van de PerrePenny MooreJean-Pierre Moles
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] Pathogenesis and Control of Chronic and Emerging Infections University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] IRCCS Ospedale San Raffaele [Milan, Italy] South African Medical Research Council [Cape Town, South Africa] IRCCS Ospedale San Raffaele [Milan, Italy] South African Medical Research Council [Cape Town, South Africa] Pathogenesis and Control of Chronic and Emerging Infections National Institute of Allergy and Infectious Diseases [Bethesda] University of Pretoria [South Africa] South African Medical Research Council [Cape Town, South Africa] IRCCS Ospedale San Raffaele [Milan, Italy] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] University of KwaZulu-Natal [Durban, Afrique du Sud] Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Infection le 23/10/2020

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Résumé : Objectives: The use of broadly neutralising antibodies (bNAb) to prevent HIV infection is under active investigation, including for the prevention of vertical HIV transmission. In neonates, an uncomplicated sampling method for blood collection is the use of dried blood spots (DBS). We aimed to validate the use of a combination of DBS with ELISA techniques to monitor bNAb concentrations, namely VRC07-523LS and CAP256V2LS, in neonates. Methods: We evaluated the performance of various DBS elution protocols on spiked adult blood and next on spiked cord blood. The optimised method was validated on blood from infants injected with bNAbs. Results: After selecting the best elution conditions, we reported good repeatability and reproducibility for both bNAbs in cord blood samples. The concordance study with infant receiving VRC07-523LS or CAP256V2LS samples showed that the values obtained from DBS eluates were closely aligned with those from plasma samples and when corrected by the haematocrit value, the number of outliers was 10.1% with a positive bias of 0.35 µg/mL for CAP256V2LS, and 5.0% with a positive bias of 3 µg/mL for VRC07-523LS. Conclusions: DBS microsampling allows accurate bNAb concentration measure in neonates, which will facilitate on-going paediatric clinical trials and possible subsequent monitoring in adults with home-sampling if deployed at scale.

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Fichiers liés : 1-s2.0-S0163445326000046-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Loren MorgilloLèna BrionneXavier FalourdJérôme AdrienBérangère LesaintVictor TrillaudThibaut ColinartPierre OuagnePhilippe SteyerMarwa AbidaJohnny BeaugrandAlain Bourmaud
• Organismes : Institut de Recherche Dupuy de Lôme Unité de recherche sur les Biopolymères, Interactions Assemblages Unité de recherche sur les Biopolymères, Interactions Assemblages BIBS - Plateforme Bioressources : Imagerie, Biochimie & Structure Matériaux, ingénierie et science [Villeurbanne] Matériaux, ingénierie et science [Villeurbanne] Matériaux, ingénierie et science [Villeurbanne] Consortium Lyon Saint-Etienne de Microscopie Institut de Recherche Dupuy de Lôme Université de Bretagne Sud Institut de Recherche Dupuy de Lôme Université de Technologie Tarbes Occitanie Pyrénées Matériaux, ingénierie et science [Villeurbanne] Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux Unité de recherche sur les Biopolymères, Interactions Assemblages Institut de Recherche Dupuy de Lôme
• Publié dans Industrial Crops and Products le 27/10/2020

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Résumé : Flax fibres are increasingly explored as sustainable reinforcements in high-performance composites due to their remarkable stiffness and strength. However, their hygroscopic nature and complex hierarchical organisation pose challenges for dimensional stability and long-term durability. Among the intrinsic microstructural heterogeneities, kink-bands, localised deformations associated with cellulose misalignment and increased porosity, may affect water uptake and swelling. Despite their potential impact, the effect of kink-bands on water sorption and moisture-induced structural changes has not been directly investigated. This study investigates the influence of kink-band density on the hygroscopic behaviour of flax fibres using an integrated multi-scale approach combining Dynamic Vapour Sorption (DVS), Environmental Scanning Electron Microscopy (ESEM), X-ray microtomography, and solid-state Nuclear Magnetic Resonance (ss-NMR). Three flax fibre batches with distinct kink-band frequencies were prepared through controlled mechanical processing. DVS results revealed no significant difference in overall water sorption capacity between batches, indicating that kink-bands do not markedly affect global hygroscopicity. However, ESEM and X-ray tomography analyses highlighted heterogeneous swelling behaviour at the bundle and fibre scales, with kink-band regions exhibiting lower expansion than intact zones, suggesting a compensating effect of internal pores on local deformation. Solid-state NMR analyses revealed that, although fibril dimensions and overall crystallinity were unchanged, fibres with higher kink-band content exhibited increased water accessibility and subtle nanoscale polymer reorganisation. This suggests that kink-bands promote local water penetration and interactions with surrounding non-cellulosic components, without altering overall bulk hygroscopicity. Together, these results indicate that kink-bands modulate local moisture dynamics, providing new insights into the structural–functional relationships governing flax fibre behaviour in humid environments. They are also relevant for natural fibre composites, as understanding how kink-bands influence local moisture dynamics can inform predictions of dimensional stability, fibre–matrix interactions, and long-term durability.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Santiago BotíaCléo Quaresma Dias JúniorShujiro KomiyaAuke van der WoudeMyriam TerristiRemco J. de KokGerbrand KorenHella van AsperenSam P. JonesFlávio Augusto Farias d'OliveiraUlrich WeberEdson P. Marques‐filhoIvan Mauricio CelyAlessandro AraujoJošt LavričDavid WalterX. LiWigneron J.-P.Benjamin David StockerJefferson Gonçalves de SouzaMike O'SullivanStephen SitchPhilippe CiaisFrederic ChevallierWei LiIngrid T LuijkxWouter PetersCarlos Alberto QuesadaSönke ZaehleSusan TrumboreAna Bastos
• Organismes : Max-Planck-Institut für Biogeochemie instituto Federal de Educaçao, Ciência e Tecnologia Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry Wageningen University and Research [Wageningen] Universität Leipzig = Leipzig University SRON Netherlands Institute for Space Research Copernicus Institute of Sustainable Development [Utrecht] Max-Planck-Institut für Biogeochemie The Alliance of Bioversity International and International Center for Tropical Agriculture (CIAT) [France] instituto Federal de Educaçao, Ciência e Tecnologia Università degli studi della Tuscia = Tuscia University [Viterbo] Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry Universidade Federal da Bahia = Federal University of Bahia Universidade de São Paulo = University of São Paulo EMBRAPA Amazônia Oriental ACOEM Max Planck Institute for Chemistry Multiphase Chemistry Department [Mainz] Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Oeschger Centre for Climate Change Research University of Exeter University of Exeter University of Exeter Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation INVerse pour les mesures atmosphériques et SATellitaires Qing hua da xue = Tsinghua University = Université Tsinghoua [Beijing] Wageningen University and Research [Wageningen] Wageningen University and Research [Wageningen] Instituto Nacional de Pesquisas da Amazônia = National Institute of Amazonian Research Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry Universität Leipzig = Leipzig University
• Publié dans AGU Advances le 27/10/2020

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Résumé : In 2023, the biogeographic Amazon experienced temperature anomalies of 1.5°C above the 1991-2020 average from September to November. These conditions were driven by high sea surface temperature in the Atlantic and Pacific oceans, together with reduced moisture advection from the Atlantic, causing large vapor pressure and water deficits in the second semester of 2023. Here, we evaluate the response of the Amazon carbon cycle to this extreme event across different spatial scales. We combined atmospheric CO 2 mole fractions and eddy covariance flux data from the Amazon Tall Tower Observatory (ATTO, -2.1441, -58.99), low-latency simulations by Dynamic Global Vegetation Models (DGVMs), an atmospheric inversion, and remote sensing data. We find that in 2023 the Amazon region was, including fires, a net carbon source of 0.01-0.17 PgC. Fire emissions (0.15 [0.13-0.17] PgC) were within typical variability of the 2003-2023 period, thus we attribute the weak carbon source to reduced vegetation uptake during the dry season (August-October). A stronger-than-normal vegetation uptake early in the year (January-April), consistent across data streams and spatial scales, mitigated the total carbon losses by the end of the year. We find a shift from carbon sink to source in May and a peak source in October. Our findings show a reduced vegetation carbon uptake over the Amazon region, leading to a weak carbon source that contributed up to 30% of the net carbon loss in the tropical land in 2023.

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Fichiers liés : AGU Advances - 2026 - Botía - Reduced Vegetation Uptake During the Extreme 2023 Drought Turns the Amazon Into a Weak Carbon.pdf

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