Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : John B WhitfieldTae-Hwi Schwantes-AnRebecca DarlayGuruprasad P AithalStephen R AtkinsonRamon BatallerGreg BotwinNaga P ChalasaniHeather J CordellAnn K DalyChristopher P DayFlorian EyerTatiana ForoudDermot GleesonDavid GoldmanPaul S HaberJean-Marc JacquetTiebing LiangSuthat LiangpunsakulSteven MassonPhilippe MathurinRomain MoirandAndrew McquillinChristophe MorenoMarsha y MorganSebastian MuellerBeat MüllhauptLaura E NagyPierre NahonBertrand NalpasSylvie NaveauPascal PerneyMunir PirmohamedHelmut K SeitzMichael SoykaFelix StickelAndrew ThompsonMark R ThurszEric TrépoTimothy R MorganDevanshi Seth
• Organismes : QIMR Berghofer Medical Research Institute Indiana University School of Medicine Newcastle University [Newcastle] University of Nottingham, UK Imperial College London University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] California State University [Long Beach] Indiana University - Purdue University Indianapolis Newcastle University [Newcastle] Newcastle University [Newcastle] Newcastle University [Newcastle] Technische Universität Munchen = Technical University Munich = Université Technique de Munich Indiana University School of Medicine National Institute on Alcohol Abuse and Alcoholism The University of Sydney Hôpital Universitaire Carémeau [Nîmes] Indiana University - Purdue University Indianapolis Indiana University System Newcastle University [Newcastle] Hôpital Claude Huriez [Lille] Institute for Translational Research in Inflammation - U 1286 Nutrition, Métabolismes et Cancer University College London [UCL] Université libre de Bruxelles = Free University of Brussels University College London [UCL] University of Heidelberg, Medical Faculty University hospital of Zurich [Zurich] Lerner Research Institute [Cleveland, OH, USA] Génomique Fonctionnelle des Tumeurs Solides Hôpital Universitaire Carémeau [Nîmes] AP-HP - Hôpital Antoine Béclère [Clamart] Centre de recherche en épidémiologie et santé des populations Hôpital Universitaire Carémeau [Nîmes] University of Liverpool University of Heidelberg, Medical Faculty University-Hospital Munich-Großhadern [München] University hospital of Zurich [Zurich] University of Liverpool Imperial College London Université libre de Bruxelles = Free University of Brussels University of California The University of Sydney
• Publié dans Journal of Hepatology le 23/10/2020

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Résumé : Background & aims - Only a minority of excess alcohol drinkers develop cirrhosis. We developed and evaluated risk stratification scores to identify those at highest risk. Methods - Three cohorts (GenomALC-1: n = 1,690, GenomALC-2: n = 3,037, UK Biobank: relevant n = 6,898) with a history of heavy alcohol consumption (≥80 g/day (men), ≥50 g/day (women), for ≥10 years) were included. Cases were participants with alcohol-related cirrhosis. Controls had a history of similar alcohol consumption but no evidence of liver disease. Risk scores were computed from up to 8 genetic loci identified previously as associated with alcohol-related cirrhosis and 3 clinical risk factors. Score performance for the stratification of alcohol-related cirrhosis risk was assessed and compared across the alcohol-related liver disease spectrum, including hepatocellular carcinoma (HCC). Results - A combination of 3 single nucleotide polymorphisms (SNPs) (PNPLA3:rs738409, SUGP1-TM6SF2:rs10401969, HSD17B13:rs6834314) and diabetes status best discriminated cirrhosis risk. The odds ratios (ORs) and (95% CIs) between the lowest (Q1) and highest (Q2) score quintiles of the 3-SNP score, based on independent allelic effect size estimates, were 5.99 (4.18-8.60) (GenomALC-1), 2.81 (2.03-3.89) (GenomALC-2), and 3.10 (2.32-4.14) (UK Biobank). Patients with diabetes and high risk scores had ORs of 14.7 (7.69-28.1) (GenomALC-1) and 17.1 (11.3-25.7) (UK Biobank) compared to those without diabetes and with low risk scores. Patients with cirrhosis and HCC had significantly higher mean risk scores than patients with cirrhosis alone (0.76 ± 0.06 vs. 0.61 ± 0.02, p = 0.007). Score performance was not significantly enhanced by information on additional genetic risk variants, body mass index or coffee consumption. Conclusions - A risk score based on 3 genetic risk variants and diabetes status enables the stratification of heavy drinkers based on their risk of cirrhosis, allowing for the provision of earlier preventative interventions. Lay summary - Excessive chronic drinking leads to cirrhosis in some people, but so far there is no way to identify those at high risk of developing this debilitating disease. We developed a genetic risk score that can identify patients at high risk. The risk of cirrhosis is increased >10-fold with just two risk factors - diabetes and a high genetic risk score. Risk assessment using this test could enable the early and personalised management of this disease in high-risk patients.

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Fichiers liés : Whitfield et al-2021-A genetic risk score and diabetes predict development of alcohol-related.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Amélie BourhisCharline CaumontIsabelle Quintin-RouéElsa MagroGurvan DissauxAnnabelle RemouéPierre Le Noac’hNathalie Douet-GuilbertRomuald SeizeurAlexandra TyulyandinaUlrike SchickJean-Philippe MerlioPascale MarcorellesDavid CappellenArnaud Uguen
• Organismes : Centre Hospitalier Régional Universitaire de Brest CHU de Bordeaux Pellegrin [Bordeaux] Bordeaux Research In Translational Oncology [Bordeaux] Centre Hospitalier Régional Universitaire de Brest Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Régional Universitaire de Brest Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Régional Universitaire de Brest CHRU Brest - Laboratoire d'Anatomo-Pathologie Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Centre Hospitalier Régional Universitaire de Brest Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Régional Universitaire de Brest Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Régional Universitaire de Brest Bordeaux Research In Translational Oncology [Bordeaux] CHU de Bordeaux Pellegrin [Bordeaux] Centre Hospitalier Régional Universitaire de Brest Laboratoire sur les interactions Epithéliums Neurones CHU de Bordeaux Pellegrin [Bordeaux] Bordeaux Research In Translational Oncology [Bordeaux] Lymphocytes B, Autoimmunité et Immunothérapies Centre Hospitalier Régional Universitaire de Brest
• Publié dans Pathology le 02/11/2020

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Résumé : Glioblastomas are frequent malignant brain tumours with a very poor prognosis and a need for new and efficient therapeutic strategies. With the approval of anti-TRK targeted therapies to treat patients with advanced NTRK-rearranged cancers, independent of the type of cancer, potential new treatment opportunities are available for the 0.5-5% of patients with NTRK-rearranged glioblastomas. Identification of these rare NTRK-rearranged glioblastomas requires efficient diagnostic tools and strategies which are evaluated in this study. We compared the results of NTRK1, NTRK2 and NTRK3 fluorescent in situ hybridisation (FISH) assays to those of pan-TRK immunohistochemistry (IHC) using two EPR17341 and A7H6R clones in a set of 196 patients with glioblastomas. Cases with at least 15% of positive nuclei using FISH analyses were further analysed using RNA sequencing. Above the 15% threshold, seven positive glioblastomas (3.57%) were identified by FISH assays (4 NTRK1, 3 NTRK2, no NTRK3). NTRK rearrangements were confirmed by RNA sequencing analyses in four cases [1 LMNA-NTRK1, 1 PRKAR2A-NTRK2, 1 SPECC1L-NTRK2 and 1 NACC2-NTRK2 fusions, i.e., 4/196 (2%) of NTRK-rearranged tumours in our series] but no rearrangement was detected in three samples with less than 30% of positive tumour nuclei as determined by NTRK1 FISH. Pan-TRK immunostaining showed major discrepancies when using either the EPR17341 or the A7H6R clones for the following criteria: main intensity, H-Score based scoring and homogeneity/heterogeneity of staining (Kappa values <0.2). This led to defining adequate criteria to identify NTRK-rearranged gliomas exhibiting strong and diffuse immunostaining contrasting to the variable and heterogeneous staining in non-NTRK-rearranged gliomas (p<0.0001). As assessing NTRK rearrangements has become crucial for glioma therapy, FISH seems to be a valuable tool to maximise access to TRK testing in patients with glioblastomas. In contrast to other cancers, pan-TRK IHC appears of limited interest in this field because there is no 'on/off' IHC positivity criterion to distinguish between NTRK-rearranged and non-NTRK-rearranged gliomas. RNA sequencing analyses are necessary in FISH positive cases with less than 30% positive nuclei, to avoid false positivity when scoring is close to the detection threshold.

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Fichiers liés : S0031302521004293.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Marc HilmiElisabeth AshtonMatthieu DelayePhilippe GiraudCindy NeuzilletJean-Philippe SpanoJoseph GligorovLuc OllivierAdrien RousseauNatacha NaounAlice Boilève
• Organismes : UFR Sciences de la santé Simone Veil Institut Curie [Paris] Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Bulletin du Cancer le 01/11/2020

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Résumé : Introduction > L'Association d'enseignement et de recherche des internes en oncologie (AERIO) a mené une enquête nationale auprès des internes en « phase socle » de la promotion 2020 du diplôme d'études spécialisées d'oncologie. L'objectif était de recueillir et décrire leurs motivations, ainsi que les objectifs et les obstacles de vie et de carrière de ces internes, lors de cette première année de leur cursus. Méthodes > Un questionnaire comprenait 45 questions fermées réparties en six sections permettant de décrire : les caractéristiques démographiques de la population interrogée, l'engagement et les attentes cliniques et liées à la recherche des étudiants, leur formation, leurs objectifs de vie et de carrière, ainsi que leur engagement associatif. Résultats > Soixante-dix-huit internes sur 119 ont participé (66 %), dont 68 (87 %) ayant complété le questionnaire dans son intégralité. La population était constituée en majorité de femmes (60 %) avec un âge médian de 24 ans. Le choix entre oncologie option médicale ou option radiothérapie était le plus souvent indéterminé (87 %), 15 % des internes ont songé au droit au remord. Le temps de travail hospitalier moyen déclaré était majoritairement situé entre 45 et 65 heures par semaine (83 %). Soixante-neuf pour cent souhaitaient s'investir dans la recherche clinique. Environ un interne sur deux (52 %) n'avait pas accès à la demi-journée de formation en autonomie. Conclusion > Cette étude nationale a permis de décrire la perception des internes en phase socle d'oncologie vis à vis de leur formation, ainsi que leurs aspirations de carrière et leur rapport à la recherche.

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Fichiers liés : [Goals, motivations, and difficulties of young oncology residents]..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Jean-Pierre GangneuxEric DannaouiArnaud FekkarCharles-Edouard LuytFrançoise BotterelNicolas de ProstJean-Marc TadiéFlorian ReizineSandrine HouzéJean-François TimsitXavier IriartBéatrice Riu-PoulencBoualem SendidSaad NseirFlorence PersatFlorent WalletPatrice Le PapeEmmanuel CanetAna NovaraMelek ManaiEstelle CateauArnaud W. ThilleSophie BrunYves CohenAlexandre AlanioBruno MégarbaneMuriel CornetNicolas TerziLionel LamhautEstelle SabourinGuillaume DesoubeauxStephan EhrmannC. HennequinGuillaume VoiriotGilles NevezCécile AubronFerhat MezianiMarion BlaizeJulien MayauxAntoine MonselFrédérique BoquelFlorence Robert-GangneuxYves Le TulzoPhilippe SeguinHélène GueganBrice AutierMatthieu LesouhaitierRomain PelletierSorya BelazChristine BonnalAntoine BerryJordan LeroyNadine FrançoisJean-Christophe RichardSylvie PaulusLaurent ArgaudDamien DupontJean MenottiFlorent MorioMarie SouliéCarole SchwebelCécile GarnaudJuliette GuitardSolène Le GalDorothée QuinioJeff MorcetBruno LaviolleJean-Ralph ZaharMarie-Elizabeth Bougnoux
• Organismes : Centre Hospitalier Universitaire [Rennes] Hôpital Européen Georges Pompidou [APHP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Henri Mondor [Créteil] CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Hospices Civils de Lyon Hospices Civils de Lyon Research on Healthcare Performance Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Avicenne [AP-HP] Hôpital Avicenne [AP-HP] Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] CHU Trousseau [Tours] Centre d’Etude des Pathologies Respiratoires [Tours] CHU Trousseau [Tours] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Centre Hospitalier Régional Universitaire de Brest SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Universitaire [Strasbourg] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Hôpital Avicenne [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire [Strasbourg] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Hôpital Avicenne [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Institut Pasteur [Paris]
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : BACKGROUND: Patients with severe COVID-19 have emerged as a population at high risk of invasive fungal infections (IFIs). However, to our knowledge, the prevalence of IFIs has not yet been assessed in large populations of mechanically ventilated patients. We aimed to identify the prevalence, risk factors, and mortality associated with IFIs in mechanically ventilated patients with COVID-19 under intensive care. METHODS: We performed a national, multicentre, observational cohort study in 18 French intensive care units (ICUs). We retrospectively and prospectively enrolled adult patients (aged ≥18 years) with RT-PCR-confirmed SARS-CoV-2 infection and requiring mechanical ventilation for acute respiratory distress syndrome, with all demographic and clinical and biological follow-up data anonymised and collected from electronic case report forms. Patients were systematically screened for respiratory fungal microorganisms once or twice a week during the period of mechanical ventilation up to ICU discharge. The primary outcome was the prevalence of IFIs in all eligible participants with a minimum of three microbiological samples screened during ICU admission, with proven or probable (pr/pb) COVID-19-associated pulmonary aspergillosis (CAPA) classified according to the recent ECMM/ISHAM definitions. Secondary outcomes were risk factors of pr/pb CAPA, ICU mortality between the pr/pb CAPA and non-pr/pb CAPA groups, and associations of pr/pb CAPA and related variables with ICU mortality, identified by regression models. The MYCOVID study is registered with ClinicalTrials.gov, NCT04368221. FINDINGS: Between Feb 29 and July 9, 2020, we enrolled 565 mechanically ventilated patients with COVID-19. 509 patients with at least three screening samples were analysed (mean age 59·4 years [SD 12·5], 400 [79%] men). 128 (25%) patients had 138 episodes of pr/pb or possible IFIs. 76 (15%) patients fulfilled the criteria for pr/pb CAPA. According to multivariate analysis, age older than 62 years (odds ratio [OR] 2·34 [95% CI 1·39-3·92], p=0·0013), treatment with dexamethasone and anti-IL-6 (OR 2·71 [1·12-6·56], p=0·027), and long duration of mechanical ventilation (\textgreater14 days; OR 2·16 [1·14-4·09], p=0·019) were independently associated with pr/pb CAPA. 38 (7%) patients had one or more other pr/pb IFIs: 32 (6%) had candidaemia, six (1%) had invasive mucormycosis, and one (\textless1%) had invasive fusariosis. Multivariate analysis of associations with death, adjusted for candidaemia, for the 509 patients identified three significant factors: age older than 62 years (hazard ratio [HR] 1·71 [95% CI 1·26-2·32], p=0·0005), solid organ transplantation (HR 2·46 [1·53-3·95], p=0·0002), and pr/pb CAPA (HR 1·45 [95% CI 1·03-2·03], p=0·033). At time of ICU discharge, survival curves showed that overall ICU mortality was significantly higher in patients with pr/pb CAPA than in those without, at 61·8% (95% CI 50·0-72·8) versus 32·1% (27·7-36·7; p\textless0·0001). INTERPRETATION: This study shows the high prevalence of invasive pulmonary aspergillosis and candidaemia and high mortality associated with pr/pb CAPA in mechanically ventilated patients with COVID-19. These findings highlight the need for active surveillance of fungal pathogens in patients with severe COVID-19. FUNDING: Pfizer.

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Fichiers liés : MYCOVID_20210323.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Luigi PisaniAnna Geke AlgeraAry Serpa NetoLuciano AzevedoTài PhamFrederique PaulusMarcelo Gama de AbreuPaolo PelosiArjen DondorpGiacomo BellaniJohn LaffeyMarcus SchultzAmadeu MartinezLivia LealAntonio Jorge PereiraMarcelo de Oliveira MaiaJosè Aires NetoClaudio PirasEliana Bernadete CaserCora Lavigne MoreiraPablo Braga GusmanDyanne Moysés DalcomuneAlexandre Guilherme Ribeiro de CarvalhoLouise Aline Romão GondimLívia Mariane Castelo Branco ReisDaniel da Cunha RibeiroLeonardo de Assis SimõesRafaela Siqueira CamposJosé Carlos Fernandez Versiani dos AnjosFrederico Bruzzi CarvalhoRossine Ambrosio AlvesLilian Batista NunesÁlvaro Réa-NetoMirella Cristine de OliveiraLuana TannousBrenno Cardoso GomesFernando Borges RodriguezPriscila AbelhaMarcelo LugarinhoAndre JapiassuHélder Konrad de MeloElton Afonso LopesPedro VaraschinVicente Cés de Souza DantasMarcos Freitas KnibelMicheli PontePedro Mendes de Azambuja RodriguesRubens Carmo Costa FilhoFelipe SaddyThéia Forny Wanderley CastellõesSuzana Alves SilvaLuiz Antonio Gomes OsorioDora MannarinoRodolfo EspinozaCassia RighyMarcio SoaresJorge SalluhLilian TanakaDaniel AragãoMaria Eduarda TavaresMaura Goncalves Pereira KehdiValéria Maria Campos RezendeRoberto Carlos Cruz CarbonellCassiano TeixeiraRoselaine Pinheiro de OliveiraJuçara Gasparetto MaccariPriscylla Souza CastroPaula BertoPatricia SchwarzAndré Peretti TorellyThiago LisboaEdison MoraesFelipe Dal-PizzolCristiane Tomasi DamianiCristiane RitterJuliana Carvalho FerreiraRamon Teixeira CostaPedro CarusoCristina Prata AmendolaAmanda Maria R R de OliveiraUlysses SilvaLuciana Coelho SanchesRosana AlmeidaLuciano Cesar AzevedoMarcelo ParkGuilherme SchettinoMurillo Santucci AssunçãoEliezer SilvaCarlos Eduardo BarbozaAntonio Paulo Nassar JuniorPaulo Fernando G M Marzocchi TiernoLuis Marcelo MalbouissonLucas OliveiraDavi CristovaoManoel Leitão NetoÊnio RegoFernanda Eugênia FernandesMarcelo Luz Pereira RomanoAlexandre Biasi CavalcantiDalton de Souza BarrosÉrica Aranha SuzumuraKarla Loureiro MeiraGustavo Affonso de OliveiraPaula Menezes LucianoEvelin Drociunas PachecoBruno Franco MazzaFlavia Ribeiro MachadoElaine FerreiraRonaldo Batista dos SantosAlexandra Siqueira ColomboAntonio Carlos NogueiraJuliana Baroni FernandesRaquel Siqueira NóbregaBarbara Do Cs MartinsFrancisco SorianoRafaela Deczka MorschAndre Luiz Baptiston NunesJuliano Pinheiro de AlmeidaLudhmila HajjarSílvia MoulinFábio Poianas GianniniAndre Luiz Baptiston NunesFernando RiosFrank van HarenT SottiauxFredy LoraLuciano AzevedoP DepuydtEddy FanGuillermo BugedoHaibo QiuMarcos GonzalezJuan SileskyVladimir CernyJonas NielsenManuel JibajaTài PhamHermann WriggeDimitrios MatamisJorge Luis RaneroS HashemianPravin AminKevin ClarksonGiacomo BellaniKiyoyasu KurahashiAsisclo VillagomezAmine Ali ZeggwaghLeo HeunksJon Henrik LaakeJose Emmanuel PaloAntero Do Vale FernandesDorel SandescYaasen ArabiVesna BumbasierevicJose LorenteAnders LarssonLise PiquilloudFekri AbrougDaniel McauleyLia McnameeJavier HurtadoEd BajwaGabriel DémpaireGuy FrancoisHektor SulaLordian NunciAlma CaniAlan ZazuChristian DelleraCarolina InsaurraldeRisso AlejandroJulio DaldinMauricio VinzioRuben FernandezLuis CardonnetLisandro BettiniMariano Carboni BissoEmilio OsmanMariano SettenPablo LovazzanoJavier AlvarezVeronica VillarCesar MilsteinNorberto PozoNicolas GrubissichGustavo PlotnikowDaniela VasquezSantiago IlutovichNorberto TiribelliAriel ChenaCarlos PellegriniMaría SaenzElisa EstenssoroMatias BrizuelaHernan GianinettoPablo GomezValeria CerratoMarco BezziSilvina BorelloFlavia LoiaconoAdriana FernandezSerena KnowlesClaire ReynoldsDeborah InskipJennene MillerJing KongChristina WhiteheadShailesh BihariAylin SevenAmanda KrstevskiHelen RodgersRebecca MillarToni MckennaIrene BaileyGabrielle HanlonAnders AnemanJoan LynchRaman AzadJohn NealPaul WoodsBrigit RobertsMark KolHelen WongKatharina RissThomas StaudingerXavier WitteboleCaroline BerghePierre BulpaAlain DiveRik VerstraeteHerve LebbinckPieter DepuydtJoris VermassenPhilippe MeerssemanHelga CeunenJonas RosaDaniel BeraldoClaudio PirasAdenilton AmpinelliAntonio Nassar JrSergio MatalounMarcelo MoockMarlus ThompsonClaudio GonçalvesAna Carolina P AntônioAline AscoliRodrigo BiondiDanielle FonteneleDanielle NobregaVanessa SalesSuresh ShindheDk Maizatul Aiman B Pg Hj IsmailJohn LaffeyFrancois BeloncleKyle DaviesRob CironeVenika ManoharanMehvish IsmailEwan GoligherMandeep JassalErin NishikawaAreej JaveedGerard CurleyNuttapol RittayamaiMatteo ParottoNiall FergusonSangeeta MehtaJenny KnollAntoine PronovostSergio CanestriniAlejandro BruhnPatricio GarciaFelipe AliagaPamela FaríasJacob YumhaClaudia OrtizJavier SalasAlejandro SaezLuis VegaEduardo LabarcaFelipe MartinezNicolás CarreñoPilar LoraHaitao LiuHaibo QiuLing LiuRui TangXiaoming LuoYouzhong AnHuiying ZhaoYan GaoZhe ZhaiZheng YeWei WangWenwen LiQingdong LiRuiqiang ZhengWenkui YuJuanhong ShenXinyu LiTao YuWeihua LuYa WuXiao HuangZhenyang HeYuanhua LuHui HanFan ZhangRenhua SunHua WangShu QinBao ZhuJun ZhaoJian LiuBin LiJing LiuFa ZhouQiong LiXing ZhangZhou Li-XinQiang Xin-HuaLiangyan JiangYuan GaoXian ZhaoYuan LiXiao LiChunting WangQingchun YaoRongguo YuKai ChenHuanzhang ShaoBingyu QinQing HuangWei ZhuAi HangMa HuaYimin LiYonghao XuYu DiLong LingTie QinShou WangJunping QinYi HanSuming ZhouMonica VargasJuan Silesky JimenezManuel González RojasJaime Solis-QuesadaChristian Ramirez-AlfaroJan MácaPeter SklienkaJakob GjedstedAage ChristiansenJonas NielsenBoris VillamaguaMiguel LlanoPhilippe BurtinGautier BuzancaisPascal BeuretNicolas PelletierSatar MortazaAlain MercatJonathan ChellySébastien JochmansNicolas TerziCédric DaubinGuillaume CarteauxNicolas de ProstJean-Daniel ChicheFabrice DaviaudTài PhamMuriel FartoukhGuillaume BarberetJerome BiehlerJean DellamonicaDenis DoyenJean-Michel ArnalAnais BriquetSami HraiechLaurent PapazianArnaud FollinDamien RouxJonathan MessikaEvangelos KalaitzisLaurence DangersAlain CombesSiu-Ming AuGaetan BéduneauDorothée CarpentierElie ZogheibHervé DupontSylvie RicomeFrancesco SantoliSebastien BessetPhilippe MichelBruno GeléePierre-Eric DaninBernard GoubauxPhilippe CrovaNga PhanFrantz BerkelmansJulio BadieRomain TapponnierJosette GallySamy KhebbebJean-Etienne HerbrechtFrancis SchneiderPierre-Louis DeclercqJean-Philippe RigaudJacques DuranteauAnatole HarroisRussell ChabanneJulien MarinCharlene BigotSandrine ThibaultMohammed GhaziMessabi BoukhaznaSalem Ould ZeinJack RichecoeurDaniele CombauxFabien GrelonCharlene Le MoalElise SauvadetAdrien RobineVirginie LemialeDanielle ReuterMartin DresAlexandre DemouleDany Goldgran-ToledanoLoredana BaboiClaude GuérinRalph LohnerJens KraßlerSusanne SchäferKai ZacharowskiPatrick MeybohmAndreas ReskePhilipp SimonHans-Bernd HopfMichael SchuetzThomas BaltusMetaxia PapanikolaouTheonymfi PapavasilopoulouGiannis ZacharasVasilis OurailogloyEleni MouloudiEleni MassaEva NagyElectra StamouEllada KiourtzievaMarina OikonomouLuis AvilaCesar CortezJohanna CitalánSameer JogSafal SableBhagyesh ShahMohan GurjarArvind BaroniaMohammedfaruk MemonRadhakrishnan MuthuchellappanVenkatapura RameshAnitha ShenoyRamesh UnnikrishnanSubhal DixitRachana RhayakarNagarajan RamakrishnanVallish BhardwajHeera MahtoSudha SagarVijayanand PalaniswamyDeeban GanesanSeyed Mohammadreza HashemianHamidreza JamaatiFarshad HeidariEdel MeaneyAlistair NicholKarl KnapmanDonall O'CroininEimhin DunneDorothy BreenKevin ClarksonRola JaafarRory DwyerFahd AmirOlaitan AjetunmobiAogan O'MuircheartaighColin BlackNuala TreanorDaniel CollinsWahid AltafGianluca ZaniMaurizio FusariSavino SpadaroCarlo VoltaRomano GrazianiBarbara BrunettiniSalvatore PalmesePaolo FormentiMichele UmbrelloAndrea LombardoElisabetta PecciMarco BotteriMonica SavioliAlessandro ProttiAlessia MatteiLorenzo SchiavoniAndrea TinnirelloManuel TodeschiniAntonino GiarratanoAndrea CortegianiSara SherAnna RossiMassimo AntonelliLuca MontiniPaolo CasalenaSergio ScafettiGiovanna PanarelloGiovanna OcchipintiNicolò PatronitiMatteo PozziRoberto BiscioneMichela 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LauroAndrea CortegianiVincenzo RussottoRaffaele CaioneDonatella MestriaCarlo Alberto VoltaSavino SpadaroMarco BotteriElisa SegheliniLuca BrazziGabriele SalesDavide d'AntiniAlexandre MolinPaolo SevergniniAlessandro BacuzziLorenzo PelusoPasquale VerrastroPasquale RaimondoAgreta Gecaj-GashiFabienne SimonisPieter Roel TuinmanErna AlbertsIngrid van den HulMichael KuiperRobert Bp de WildeMatty KoopmansIsil KoseÇiler ZincirciogluNazim DoganDemet AydinAhmet Sukru DenkerUnase BuyukkocakNur AkgunGüldem TuranEvren SenturkZerrin DemirtürkPerihan Ergin ÖzcanOsman EkinciSedat SaylanGulay ErenFatma UlgerAhmet DilekHulya UlusoyUgur GoktasLokman SoyoralHuseyin TomanYavuz OrakFeda KahveciGary MillsAngela PinderRachel WalkerJonathan HarrisonJane SnellColette SeasmanRachel PearsonMichael SharmanClaire KalooNatalie BynorthKelly MatthewsChloe HughesAlastair RoseKaren SimesonLotta NiskaNathan HunekeJane AdderlyCheryl Padilla-HarrisRebecca OliverFarooq BrohiNatalie WilsonHelen TalbotDeborah WilsonDeborah 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ReschreiterJulie CamsooksaiNicola VennerHelena Barcraft-BarnesLee TbailyDavid PogsonJohanna MoulandSteve RoseNicola LambNicholas TarmeyJohn KnightonJulian GilesDebbie WellerIsabelle ReedAnil HormisSallyane PearsonMeredith HarrisJoanne HoweJonathan PaddleKaren BurtIngeborg WeltersAnna WalkerLaura YoudsSam HendryDavid ShawKaren WilliamsRobin HollandsMandy CarnahanJohanna StickleyClaire MillerDenise DonaldsonLouise TonksBen Creagh-BrownDaniel HullOwen BoydLaura Ortiz-RuizShammer GopalStella MetherellHazel SpencerChristian FreyCarly BrownGayle CliffordSusannah LeaverChristine RyanJohannes Mellinghoff MellinghoffSarah Prudden PruddenHelen Green GreenAlistair Roy RoyJulie Furneval FurnevalAdam Bell BellSandeep Lakhani LakhaniLousie Fasting FastingLorna Murray MurrayKobus PrellerAmy McinerneySarah BeavisAmanda WhilemanJulie TomsSue GlennMohamed RamaliAlison GhoshClare BullockLisa BarrellEoin YoungHelen RobertsonMaria FaulknerPeter MacnaughtonSusan TysonPaul PulakTerri-Ann SewellChristopher SmalleyReni JacobCristina SantosPedro AlzugarayMarcos Vidal MeloKristen JoyceJoseph NeedlemanAreef AhsanAbul FaizAkm Shamsul AlamSyeda Nafisa KhatoonRanjan Kumer NathMohammed Abdur Rahman ChowdhuryDebabrata BanikMontosh Kumar MondolSakibur Rahman BhuiyanSuraiya NazneedRozina SultanaTarikul HamidMozaffer HossainSyed Tariq RezaMuhammad AsaduzzamanMohammad SalimAbu Hena Mostafa KamalSheikh Mohammed TaherTaohidul Majid TaohidPranab KarmakerSabyasachi RoyShantanu DasSohel Ahmed SarkarMonju Lal DuttaPoulomi RoyShivakumar IyerBhuvana KrishnaSriram SampathRajyabardhan PattnaikChinni Krishna KasiJignesh ShahAnand DongreSeyed Mohammad Reza HashemianNavid NooraeiReza Raessi EstabraghMajid MalekmohammadBatoul KhoundabiMaziar MobasherNor'Azim Mohd YunosMahazir KassimChern Min VoonStanis Sutharsa DasSiti Nur Suhaila AzauddinDharshinie DorasamyLi Ling TaiMohd Basri Mat NorNurhafizah ZarudinMohd Shahnaz HasanMohamad Fadhil Hadi JamaluddinMohamad Irfan Othman JailaniGyan KayashtaAaradhana AdhikariRaju PangeniMadiha HashmiSonia JosephAftab AkhtarAayesha QadeerIqbal MemonSyed Muneeb AliFarah IdreesSaima KamalSadaf HanifAtta Ur RehmanArshad TaqiTanveer HussainAhmed FarooqSaleh KhaskheliMuhammad HayatKanishka IndraratnaAbigail BeaneRashan HaniffaUpeka SamaranayakeSathiyamoorthy MathanalaganAsoka GunaratneNimangee MithraratneKaushila ThilakasiriChamila PilimatalawweY DilhaniMarie FernandoKumudini RanatungeLoranthi SamarasingheManori VaasManoj EdirisooriyaChathurani SigeraJanaki ArumoliKesharie de SilvaBimal KudavidanageVisanthi PintoLakshman DissanayakeKaweesak ChittawatanaratNapplika KongpolpromUdomsak SilachamroonPrapaporn PornsuriyasakTananchai PetnakPongsasit SinghatasViratch TangsujaritvijitSuthat RungruanghiranyaAnnop PiriyapatsomKanokkarn JuntapingKonlawij TrongtrakulPoungrat ThungtitigulPattraporn TajarernmuangSunisa ChatmongkolchartRungsun BhurayanontachaiOsaree AkaraborwornAsma NavasakulpongKarjbundid SurasitLouise ThwaitesBehzad NadjmDat Vu QuocHa Nguyen Thi ThanhKinh Nguyen VanThuy Duong BichYen Lam Minh
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans The Lancet global health le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Jean-Pierre AlcarazLaurence Le CoqJérémie PourchezDominique ThomasSandrine ChazeletIsabelle BoudryMaud BarbadoSophie SilventClaire DessaleFabienne AntoineCatherine Guimier-PingaultLaurent CortellaSophie RouifNathalie Bardin-MonnierAugustin CharvetOlivier DufaudLara LeclercYoann MontigaudCoralie LaurentPaul O VerhoevenAurélie JoubertAla BouhanguelYves AndresJoël GafféDonald K MartinChristophe HuetSandrine BoissetMax MaurinPascal RumeauFrédéric CharlotEmmanuel RichaudAlexandre Moreau-GaudryVincent BonneterrePhilippe CinquinCaroline Landelle
• Organismes : Systèmes Nanobiotechnologiques et Biomimétiques IMT Atlantique Valorisation Energie-matière des Résidus et Traitement des Emissions Laboratoire de génie des procédés - environnement - agroalimentaire École des Mines de Saint-Étienne Santé Ingénierie Biologie Saint-Etienne Laboratoire Réactions et Génie des Procédés Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble Centre Hospitalier Universitaire [CHU Grenoble] Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble Centre d'Investigation Clinique - Innovation Technologique [Nancy] Centre d'Investigation Clinique - Innovation Technologique [Nancy] Centre Hospitalier Universitaire [CHU Grenoble] ARC-Nucleart CEA Grenoble Ionisos SAS Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Santé Ingénierie Biologie Saint-Etienne Santé Ingénierie Biologie Saint-Etienne Santé Ingénierie Biologie Saint-Etienne Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Traitement Eau Air Métrologie Département Systèmes Energétiques et Environnement
• Publié dans Chemosphere le 29/10/2020

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Fichiers liés : 2022-Alcaraz ReUse Mask- CHEM.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Florian PhilippeNelly DubrulleBenjamin MarteauxBrice BonnetPatrick ChoisyJean‐yves BerthonLaurence GarnierNadine LeconteSandrine MilesiPierre‐yves MorvanAlex SaunoisJian‐sheng SunSandrine WeberNicole Giraud
• Organismes : DNA Gensee [Le Bourget du Lac] DNA Gensee [Le Bourget du Lac] DNA Gensee [Le Bourget du Lac] L'Oréal Recherche France LVMH Recherche GREENTECH L'Oréal Recherche France Nuxe [Boulogne Billancourt] Laboratoires Clarins Codif [Saint-Malo] Sederma [Le Perray-en-Yvelines] Structure et Instabilité des Génomes Laboratoires Clarins DNA Gensee [Le Bourget du Lac]
• Publié dans International Journal of Cosmetic Science le 30/10/2020

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Résumé : Objective: This study was initiated and conducted by several laboratories, 3 of the main cosmetic ingredient suppliers and 4 brands of cosmetics in France. Its objective is to show the interest and robustness of coupling chemical and genetic analyses in the identification of plant species. In this study, the Lavandula genus was used. Methods: In this study, we used two analytical methods. Chemical analysis from UHPLC (ultra-high-performance liquid chromatography) and genetic analysis from barcoding with genetic markers. Results: Eleven lavender species were selected (botanically authenticated) and analysed. The results show that three chemical compounds (coumaric acid hexoside, ferulic acid hexoside and rosmarinic acid) and three genetic markers (RbcL, trnH-psbA and ITS) are of interest for the differentiation of species of the genus lavandula. Conclusion: The results show that the combination of complementary analytical methods is a relevant system to prove the botanical identification of lavender species. This first study, carried out on a plant of interest for cosmetics, demonstrates the need for authentication using a tool combining genetic and chemical analysis as an advance over traditional investigation methods used alone, in terms of identification and authentication reliability.

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Fichiers liés : Intern J of Cosmetic Sci - 2021 - Philippe - Combining DNA Barcoding and Chemical fingerprints to authenticate Lavender raw.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Sophie CousinCoralie CantarelJean-Philippe GueganThibault MazardCarlos Gomez-RocaJean-Philippe MetgesCarine BelleraAntoine AdenisIphigenie KorakisPierre-Guillaume PoureauKevin BourcierMaud ToulmondeMichele KindChristophe ReyCeline AuzanneauAlban BessedeIsabelle SoubeyranAntoine Italiano
• Organismes : Bordeaux population health
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : BACKGROUND: Regorafenib has shown substantial clinical activity in patients with advanced biliary tract cancers (BTCs). Preclinical data suggested that this drug modulates antitumour immunity and is synergistic with immune checkpoint inhibition. PATIENTS AND METHODS: This is a single-arm, multicentric phase II trial. Regorafenib was given 3 weeks/4, 160 mg quaque die (once a day) (QD); avelumab 10 mg/kg IV was given every two weeks, beginning at C1D15 until progression or unacceptable toxicity. The primary end-point was the confirmed objective response rate under treatment, as per Response Evaluation Criteria in Solid Tumours 1.1. The secondary end-points included the following: 1-year non-progression rate; progression-free survival (PFS) and overall survival; safety and biomarkers studies performed on sequential tumour samples obtained at baseline and at cycle 2 day 1. RESULTS: Thirty-four patients were enrolled in four centres. Twenty-nine patients were assessable for efficacy after central radiological review. The best response was partial response for four patients (13.8%), stable disease for 11 patients (37.9%) and progressive disease for 14 patients (48.3%). The median PFS and overall survival were 2.5 months (95% confidence interval [CI] [1.9-5.5]) and 11.9 months (95%CI [6.2-NA]) respectively. The most common grade 3 or 4 clinical adverse events related to treatment were hypertension (17.6%), fatigue (14.7%) and maculopapular rash (11.8%). High baseline levels of programmed cell death ligand 1 and of indoleamine 2, 3-dioxygénase expression were associated with improved outcomes. CONCLUSIONS: Regorafenib combined with avelumab has antitumour activity in a subset of heavily pretreated biliary tract cancer population. Further investigations are needed in patients selected based on tumour microenvironment features. CLINICAL TRIAL REGISTRATION: NCT03475953.

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Fichiers liés : S0959804921012235.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Luigi PisaniAnna Geke AlgeraAry Serpa NetoLuciano AzevedoTài PhamFrederique PaulusMarcelo Gama de AbreuPaolo PelosiArjen DondorpGiacomo BellaniJohn LaffeyMarcus SchultzAmadeu MartinezLivia LealAntonio Jorge PereiraMarcelo de Oliveira MaiaJosè Aires NetoClaudio PirasEliana Bernadete CaserCora Lavigne MoreiraPablo Braga GusmanDyanne Moysés DalcomuneAlexandre Guilherme Ribeiro de CarvalhoLouise Aline Romão GondimLívia Mariane Castelo Branco ReisDaniel da Cunha RibeiroLeonardo de Assis SimõesRafaela Siqueira CamposJosé Carlos Fernandez Versiani dos AnjosFrederico Bruzzi CarvalhoRossine Ambrosio AlvesLilian Batista NunesÁlvaro Réa-NetoMirella Cristine de OliveiraLuana TannousBrenno Cardoso GomesFernando Borges RodriguezPriscila AbelhaMarcelo LugarinhoAndre JapiassuHélder Konrad de MeloElton Afonso LopesPedro VaraschinVicente Cés de Souza DantasMarcos Freitas KnibelMicheli PontePedro Mendes de Azambuja RodriguesRubens Carmo Costa FilhoFelipe SaddyThéia Forny Wanderley CastellõesSuzana Alves SilvaLuiz Antonio Gomes OsorioDora MannarinoRodolfo EspinozaCassia RighyMarcio SoaresJorge SalluhLilian TanakaDaniel AragãoMaria Eduarda TavaresMaura Goncalves Pereira KehdiValéria Maria Campos RezendeRoberto Carlos Cruz CarbonellCassiano TeixeiraRoselaine Pinheiro de OliveiraJuçara Gasparetto MaccariPriscylla Souza CastroPaula BertoPatricia SchwarzAndré Peretti TorellyThiago LisboaEdison MoraesFelipe Dal-PizzolCristiane Tomasi DamianiCristiane RitterJuliana Carvalho FerreiraRamon Teixeira CostaPedro CarusoCristina Prata AmendolaAmanda Maria R R de OliveiraUlysses SilvaLuciana Coelho SanchesRosana AlmeidaLuciano Cesar AzevedoMarcelo ParkGuilherme SchettinoMurillo Santucci AssunçãoEliezer SilvaCarlos Eduardo BarbozaAntonio Paulo Nassar JuniorPaulo Fernando G M Marzocchi TiernoLuis Marcelo MalbouissonLucas OliveiraDavi CristovaoManoel Leitão NetoÊnio RegoFernanda Eugênia FernandesMarcelo Luz Pereira RomanoAlexandre Biasi CavalcantiDalton de Souza BarrosÉrica Aranha 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VanThuy Duong BichYen Lam Minh
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans The Lancet global health le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2022
• Auteurs : Thomas PierreJean-Claude KrapezHelcio R.B. OrlandeChristophe RodietDylan Le MauxMickael CourtoisPhilippe Le MassonBernard Lamien
• Organismes : Institut de Recherche Dupuy de Lôme DOTA, ONERA [Salon-de-Provence] Federal University of Rio de Janeiro Institut de Thermique, Mécanique, Matériaux Institut de Recherche Dupuy de Lôme Institut de Recherche Dupuy de Lôme Institut de Recherche Dupuy de Lôme École Polytechnique de Ouagadougou
• Publié dans International Journal of Heat and Mass Transfer le 01/11/2020

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Résumé : This article presents the temperature and emissivity estimation of metals around their melting points using different techniques, which are based on deterministic (ordinary least squares) and Bayesian approaches. Linear and non-linear models are examined. The experimental data consist of radiative fluxes at six wavelengths, collected by a pyrometer. The apparatus is dedicated to the characterization of the physical properties of millimeter-sized metal samples at high temperatures, combining aerodynamic levitation and laser heating. Tests are performed on two metals: niobium with well-known temperature and steel.

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Fichiers liés : DOTA21181_vacceptee.pdf

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