Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 27/10/2022
• Auteurs : Omid HamidAlberto A ChiapporiJohn A ThompsonToshihiko DoiSiwen Hu-LieskovanFerry a L M EskensWilleke RosAdi DiabJean-Philippe SpanoNaiyer A RizviJeffrey S WasserEric AngevinPatrick A OttAlison ForgieWenjing YangCen GuoJeffrey ChouAnthony B El-Khoueiry
• Organismes : Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Journal for Immunotherapy of Cancer le 24/10/2020

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Résumé : Background Ivuxolimab (PF-04518600) and utomilumab (PF-05082566) are humanized agonistic IgG2 monoclonal antibodies against OX40 and 4-1BB, respectively. This first-in-human, multicenter, open-label, phase I, dose-escalation/dose-expansion study explored safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of ivuxolimab+utomilumab in patients with advanced solid tumors. Methods Dose-escalation: patients with advanced bladder, gastric, or cervical cancer, melanoma, head and neck squamous cell carcinoma, or non-small cell lung cancer (NSCLC) who were unresponsive to available therapies, had no standard therapy available or declined standard therapy were enrolled into five dose cohorts: ivuxolimab (0.1–3 mg/kg every 2 weeks (Q2W)) intravenously plus utomilumab (20 or 100 mg every 4 weeks (Q4W)) intravenously. Dose-expansion: patients with melanoma (n=10) and NSCLC (n=20) who progressed on prior anti-programmed death receptor 1/programmed death ligand-1 and/or anti-cytotoxic T-lymphocyte-associated antigen 4 (melanoma) received ivuxolimab 30 mg Q2W intravenously plus utomilumab 20 mg Q4W intravenously. Adverse events (AEs) were graded per National Cancer Institute Common Terminology Criteria for Adverse Events V.4.03 and efficacy was assessed using Response Evaluation Criteria in Solid Tumors (RECIST) V.1.1 and immune-related RECIST (irRECIST). Paired tumor biopsies and whole blood were collected to assess pharmacodynamic effects and immunophenotyping. Whole blood samples were collected longitudinally for immunophenotyping. Results Dose-escalation: 57 patients were enrolled; 2 (3.5%) patients with melanoma (0.3 mg/kg+20 mg and 0.3 mg/kg+100 mg) achieved partial response (PR), 18 (31.6%) patients achieved stable disease (SD); the disease control rate (DCR) was 35.1% across all dose levels. Dose-expansion: 30 patients were enrolled; 1 patient with NSCLC achieved PR lasting >77 weeks. Seven of 10 patients with melanoma (70%) and 7 of 20 patients with NSCLC (35%) achieved SD: median (range) duration of SD was 18.9 (13.9–49.0) weeks for the melanoma cohort versus 24.1 (14.3–77.9+) weeks for the NSCLC cohort; DCR (NSCLC) was 40%. Grade 3–4 treatment-emergent AEs were reported in 28 (49.1%) patients versus 11 (36.7%) patients in dose-escalation and dose-expansion, respectively. There were no grade 5 AEs deemed attributable to treatment. Ivuxolimab area under the concentration–time curve increased in a dose-dependent manner at 0.3–3 mg/kg doses. Conclusions Ivuxolimab+utomilumab was found to be well tolerated and demonstrated preliminary antitumor activity in selected groups of patients. Trial registration number NCT02315066 .

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Fichiers liés : First-in-human study of an OX40 (ivuxolimab) and 4-1BB (utomilumab) agonistic antibody combination in patients with advanced solid tumors..pdf

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• Type de publi. :
• Date de publi. : 26/10/2022
• Auteurs : Gustave MabiamaDieudonné AdiogoPierre-Marie PreuxJean-Claude DesportPhilippe FayemendyPierre Jésus
• Organismes : Neuroépidémiologie Tropicale Epidémiologie des Maladies Chroniques en zone tropicale Microbiology, Immunology-Hematology and Morphologic Sciences Laboratory (LMIHSM) Université de Douala = University of Douala Microbiology, Immunology-Hematology and Morphologic Sciences Laboratory (LMIHSM) Epidémiologie des Maladies Chroniques en zone tropicale

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Fichiers liés : Gustave M. Facteurs associés aux troubles neuro-cognitifs - Mode de compatibilité.pdf

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• Type de publi. :
• Date de publi. : 26/10/2022
• Auteurs : Gustave MabiamaDieudonné AdiogoPierre-Marie PreuxJean-Claude DesportPhilippe FayemendyPierre Jésus
• Organismes : Neuroépidémiologie Tropicale Epidémiologie des Maladies Chroniques en zone tropicale Microbiology, Immunology-Hematology and Morphologic Sciences Laboratory (LMIHSM) Université de Douala = University of Douala Microbiology, Immunology-Hematology and Morphologic Sciences Laboratory (LMIHSM) Epidémiologie des Maladies Chroniques en zone tropicale

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Fichiers liés : Gustave M. Facteurs associés aux troubles fonctionnels - Mode de compatibilité.pdf

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• Type de publi. :
• Date de publi. : 26/10/2022
• Auteurs : Mikael CohenOcéane Thomel-RocchiAksel SivaDarin OkudaClarisse Carra DallièreFrançoise Durand-DubiefHélène ZéphirCéline LouapreC. BensaJonathan CironEric ThouvenotBertrand BourreOlivier CasezJérôme de SèzeThibault MoreauJean-Philippe NeauDaniel PelletierOrhun KantarciMelih TutuncuNathalie DeracheCassandre Landes-ChâteauChristine Lebrun-Frenay
• Organismes : Unité de Recherche Clinique Côte d’Azur Unité de Recherche Clinique Côte d’Azur Cerrahpasa Faculty of Medicine University of Texas Southwestern Medical Center Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Lille Neurosciences & Cognition - U 1172 AP-HP - Hôpital de la Pitié Salpêtrière Service de neurologie [Hôpital Fondation Adolphe de Rothschild] Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Institut de Génomique Fonctionnelle CHU Rouen CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CIC Strasbourg Service de Neurologie [Strasbourg] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Service de neurologie [CHU de Poitiers] University of Southern California Mayo Clinic [Rochester] Cerrahpasa Faculty of Medicine Service de Neurologie [CHU Caen] Unité de Recherche Clinique Côte d’Azur Unité de Recherche Clinique Côte d’Azur

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Résumé : Introduction: Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. However global vaccination hesitancy remains and potential effect of COVID19 vaccination on disease activity needs to be assessed. Objectives: We aimed to evaluate if COVID19 vaccination or infection increased the risk of clinical conversion to multiple sclerosis or evidence of disease activity (EDA) in a cohort of RIS subjects. Methods: This multicentric observational study is based on the RISC cohort. Data regarding COVID19 infection and vaccination has been collected between January 2020 and December 2021. We compared the occurrence of clinical conversion to MS and EDA in patients according to their vaccination status. The same analysis was conducted by comparing patients according to their history of COVID19 infection. Results: 217 subjects with known vaccination status were included (Mean age: 44yrs, F/M sex ratio 2.7). 80% of subjects had a complete vaccination and 20% were incompletely or not vaccinated. Both groups did not differ regarding the main demographical data and known risk factors of conversion to MS. No difference was found concerning clinical conversion to MS in the vaccinated versus unvaccinated group (2.4% versus 2.5%, p = 0.9747). We did not observe any statistical difference regarding the rate of EDA in both groups. 20% of subjects had a history of COVID-19 infection. The rate of clinical conversion to MS in the infected compared to the non-infected group did not show any difference The global conversion rate to MS in the whole RISC cohort in 2021 was 2.64%, which is comparable with the observed rates during the four previous years (5.75%, 2.55%, 4.79%, and 4.85% per year respectively). Conclusions: Our study suggests that COVID19 vaccination does not increase the risk of clinical conversion to MS in RIS subjects and supports that immunization can be safely proposed for these patients.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/10/2022
• Auteurs : David SiniscalcoLaurence PessoniGuillaume VignaudJean-François TassinJean-François BardeauAnne BoussonniereAnne-Sophie CastanetPhilippe LeclèrePierre NickmilderLaurent BillonN. Delorme
• Organismes : Institut des Molécules et Matériaux du Mans Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux Institut de Recherche Dupuy de Lôme Polymères, colloïdes, interfaces Institut des Molécules et Matériaux du Mans Institut des Molécules et Matériaux du Mans Unité de chimie organique moléculaire et macromoléculaire Université de Mons = University of Mons Université de Mons = University of Mons Institut pluridisciplinaire de recherche sur l'environnement et les matériaux Institut des Molécules et Matériaux du Mans

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/10/2022
• Auteurs : Pierre GrimaudFabrice PetitLaurent BoiletFlorian JeanMarie LasgorceixPhilippe ChampagneAnne LerichePascal Laurent
• Organismes : Université Polytechnique Hauts-de-France INSA Institut National des Sciences Appliquées Hauts-de-France Laboratoire de Matériaux Céramiques et de Mathématiques Science des Procédés Céramiques et de Traitements de Surface

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 24/10/2022
• Auteurs : Paule-Annick DavoinePhilippe Garat
• Organismes : Spatio-temporal information systems Statistique pour le Vivant et l’Homme

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• Type de publi. : Article dans une revue
• Date de publi. : 22/10/2022
• Auteurs : Guilherme BaumgartenMorgan MadecDuc-Vinh NguyenLucas WerlingJoris PascalChunchesh Malangi GajendramurthyPhilippe BertaniJean-Pierre DjukicLuc Hebrard
• Organismes : Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Fachhochschule Nordwestschweiz [Windisch, Schweiz] = FHNW University of Applied Sciences and Arts Northwestern Switzerland Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Systèmes et Microsystèmes Hétérogènes Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
• Publié dans IEEE Transactions on Magnetics le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 21/10/2022
• Auteurs : Marie-Line MaublancJean-François GerardDenis PicotMichel GoulardPhilippe BallonJean-Pierre HamardÉric Bideau
• Organismes : Unité de recherche Comportement et Ecologie de la Faune Sauvage Unité de recherche Comportement et Ecologie de la Faune Sauvage Unité de recherche Comportement et Ecologie de la Faune Sauvage Dynamiques et écologie des paysages agriforestiers Ecosystèmes forestiers Ecosystèmes forestiers Unité de recherche Comportement et Ecologie de la Faune Sauvage
• Publié dans Journal of Sustainable Forestry le 26/10/2020

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Résumé : We conducted a field experiment to evaluate the effectiveness of neighboring vegetation to protect cherry-wood (Prunus avium) saplings against roe deer browsing and rubbing, and determine whether this protection varies according to the attractiveness of–and the physical barrier provided by–a variety of nurse shrubs. Our results show that nurse shrubs may delay roe deer browsing and rubbing on highly attractive cherry-wood saplings, even in a situation of high deer density. The most obstructing shrubs at roe deer knee to shoulder height (Populus x canescens and Cytisus scoparius) appeared to be efficient barriers, whereas the spiny shrub (Elaeagnus angustifolia) did not protect saplings more efficiently than thornless species. Yet, obstruction appeared to be less effective against browsing when the nurse species was itself browsed (Cornus sanguinea and Alnus cordata). Since roe deer may help to reduce plantation cleaning through the control of the shrub layer, especially brambles, we argue that natural methods of protection using surrounding vegetation should represent an economic and sustainable alternative to artificial protection of saplings.

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2022
• Auteurs : Flavienne BruyantRémi AmirauxMarie-Pier AmyotPhilippe ArchambaultLise ArtigueLucas Bardedo de FreitasGuislain BécuSimon BélangerPascaline BourgainAnnick BricaudEtienne BrouardCamille BrunetTonya BurgersDanielle CalebKatrine ChalutHervé ClaustreMarcel BabinVéronique Cornet-BarthauxPierre Vincent CoupelMarine CusaFanny CussetLaeticia DadaglioMarty DavelaarGabriele DeslongchampsCéline DimierJulie DinasquetDany DumontBrent ElseIgor EulaersJoannie FerlandGabrielle FilteauMarie-Hélène ForgetJérôme FortLouis FortierMartí GalíMorgane GallinariSvend-Erik GarbusNicole GarciaCatherine Gérikas RibeiroColline GombaultPriscillia GourvilClémence GoyensCindy GrantPierre-Luc GrondinPascal GuillotSandrine HillionRachel HussherFabien JouxHannah Joy-WarrenGabriel JoyalDavid KieberAugustin LafondJosé LagunasPatrick LajeunesseCatherine LalandeJade LarivièreF. LegallKarine LeblancMathieu LeblancJustine LegrasKeith LevesqueKate-Marie LewisEdouard LeymarieAude LeynaertThomas LinkowskiMartine LizotteAdriana Lopes dos SantosClaudie MarecDominique MarieGuillaume MasséPhilippe MassicotteAtsushi MatsuokaLisa MillerSharif MirshakNathalie MorataBrivaëla MoriceauPhilippe-Israël MorinSimon MorissetAnders MosbechAlfonso MucciGabrielle NadaïChristian NozaisIngrid ObernostererTimothe PaireChristos PanagiotopoulosMarie ParenteauNoémie PelletierMarc PicheralBernard QueguinerPatrick RaimbaultJoséphine RasEric RehmLlúcia Ribot LacostaJean-François RontaniBlanche Saint-BéatJulie SansouletNoé SardetCatherine SchmechtigAntoine SciandraRichard SempereCaroline SévignyJordan ToullecMargot TraginJean-Eric TremblayAnnie-Pier TrottierDaniel VaulotAnda VladoiuLei XueGustavo Yunda-Guarin
• Organismes : Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Takuvik Joint International Laboratory ULAVAL-CNRS LIttoral ENvironnement et Sociétés Institut de la Mer de Villefranche LIttoral ENvironnement et Sociétés Fédération de recherche de Roscoff Station biologique de Roscoff = Roscoff Marine Station Laboratoire d'Océanographie Microbienne Fédération de recherche de Roscoff Station biologique de Roscoff = Roscoff Marine Station Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche
• Publié dans Earth System Science Data le 23/10/2020

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Résumé : Abstract. The Green Edge project was designed to investigate the onset, life and fate of a phytoplankton spring bloom (PSB) in the Arctic Ocean. The lengthening of the ice-free period and the warming of seawater, amongst other factors, have induced major changes in arctic ocean biology over the last decades. Because the PSB is at the base of the Arctic Ocean food chain, it is crucial to understand how changes in the arctic environment will affect it. Green Edge was a large multidisciplinary collaborative project bringing researchers and technicians from 28 different institutions in seven countries, together aiming at understanding these changes and their impacts into the future. The fieldwork for the Green Edge project took place over two years (2015 and 2016) and was carried out from both an ice-camp and a research vessel in the Baffin Bay, canadian arctic. This paper describes the sampling strategy and the data set obtained from the research cruise, which took place aboard the Canadian Coast Guard Ship (CCGS) Amundsen in spring 2016. The dataset is available at https://doi.org/10.17882/59892 (Massicotte et al., 2019a).

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Fichiers liés : Bruyant et al 2022 ESSD HAL.pdf

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