Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 05/10/2022
• Auteurs : Michaela I HegglinAna BastosHeinrich BovensmannMichael BuchwitzDominic FawcettDarren GhentGemma KulkShubha SathyendranathTheodore G ShepherdShaun QueganRegine RöthlisbergerStephen BriggsCarlo BuontempoAnny CazenaveEmilio ChuviecoPhilippe CiaisDavid CrispRichard EngelenSuvarna FadnavisMartin HeroldMartin HorwathOskar JonssonGabriel KpakaChristopher J MerchantChristian MielkeThomas NaglerFrank PaulThomas PoppTristan QuaifeNick A RaynerColas RobertMarc SchröderStephen SitchSara VenturiniRobin van der SchalieMendy van der VlietJean-Pierre WigneronR. Iestyn Woolway
• Organismes : Department of Meteorology [Reading] Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry Institute of Environmental Physics [Bremen] Institute of Environmental Physics [Bremen] College of Life and Environmental Sciences [Exeter] NERC National Centre for Earth Observation NERC National Centre for Earth Observation NERC National Centre for Earth Observation Jülich Supercomputing Centre School of Mathematics and Statistics [Sheffield] Federal Office for the Environment Department of Meteorology [Reading] European Centre for Medium-Range Weather Forecasts Laboratoire d'études en Géophysique et océanographie spatiales Universidad de Alcalá [Alcalá de Henares, España] = University of Alcalá [Alcalá de Henares, Spain] = Université d'Alcalá [Alcalá de Henares, Espagne] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Jet Propulsion Laboratory European Centre for Medium-Range Weather Forecasts Indian Institute of Tropical Meteorology German Research Centre for Geosciences - Helmholtz-Centre Potsdam Technische Universität Dresden = Dresden University of Technology Swedish Environmental Protection Agency Sierra Leone Meteorological Agency, Freetown Department of Meteorology [Reading] German Federal Environmental Agency / Umweltbundesamt Environmental Earth Observation IT GmbH Department of Geography [Zürich] Deutsches Zentrum für Luft- und Raumfahrt [Köln] Department of Meteorology [Reading] Met Office Hadley Centre Centre interprofessionnel technique d'études de la pollution atmosphérique German Weather Service College of Life and Environmental Sciences [Exeter] Group on Earth Observations Planet, Harlem Interactions Sol Plante Atmosphère School of Ocean Sciences, College of Environmental Sciences and Engineering, Bangor University,
• Publié dans Frontiers in Environmental Science le 01/11/2020

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Résumé : Space-based Earth observation (EO), in the form of long-term climate data records, has been crucial in the monitoring and quantification of slow changes in the climate system-from accumulating greenhouse gases (GHGs) in the atmosphere, increasing surface temperatures, and melting sea-ice, glaciers and ice sheets, to rising sea-level. In addition to documenting a changing climate, EO is needed for effective policy making, implementation and monitoring, and ultimately to measure progress and achievements towards the overarching goals of the United Nations Framework Convention on Climate Change (UNFCCC) Paris Agreement to combat climate change. The best approach for translating EO into actionable information for policymakers and other stakeholders is, however, far from clear. For example, climate change is now self-evident through increasingly intense and frequent extreme events-heatwaves, droughts, wildfires, and flooding-costing human lives and significant economic damage, even though single events do not constitute "climate". EO can capture and visualize the impacts of such events in single images, and thus help quantify and ultimately manage them within the framework of the UNFCCC Paris Agreement, both at the national level (via the Enhanced Transparency Framework) and global level (via the Global Stocktake). We present a transdisciplinary perspective, across policy and science, and also theory and practice, that sheds light on the potential of EO to inform mitigation, including sinks and reservoirs of greenhouse gases, and adaptation, including loss and damage. Yet to be successful with this new mandate, EO science must undergo a radical overhaul: it must become more user-oriented, collaborative, and transdisciplinary; span the range from fiducial to contextual data; and embrace new technologies for data analysis (e.g., artificial intelligence). Only this will allow the creation of the knowledge base and actionable climate information needed to guide the UNFCCC Paris Agreement to a just and equitable success.

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Fichiers liés : fenvs-10-941490.pdf

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• Type de publi. :
• Date de publi. : 04/10/2022
• Auteurs : Nathalie KorboulewskyPhilippe BalandierYves BoscardinOlivier ChaintreuilCamille CouteauAdélie ChevalierYann DumasMarion GosselinJean-Pierre HamardAviva KaraAnders MårellThomas PerotSandrine Perret
• Organismes : Ecosystèmes forestiers Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers

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Résumé : Présentation du dispositif

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• Type de publi. : Article dans une revue
• Date de publi. : 03/10/2022
• Auteurs : Tobias GaussJustin RichardsCostanza TortùFrançois-Xavier AgeronSophie HamadaJulie JosseFrançois HussonAnatole HarroisThomas ScaleaValentin VivantEric MeaudreJonathan MorrisonSamue GalvagnoPierre BouzatFrançois AlbasiniOlivier BriotLaurent ChaboudSophie Chateigner CoelschAlexandre ChaumatThomas ComlarOlivier DebasGuillaume DebatyEmmanuelle Dupré-NaletSamuel GayEdouard GinestieEdouard GirardJules GrèzeMarc HaesevoetsMarie HallainEtienne HallerChristophe HoareauBernard LanaspreSafia LespinasseAlbrice LevratRomain Mermillod-BlondinPhilippe NicoudElisabeth RancurelJean-Marc ThouretClaire VallenetCécile VallotBénédicte ZerrPaér-Sélim AbbackGérard AudibertMathieu BoutonnetThomas ClavierFabrice CookMohamed EljamriThierry FlochElisabeth GaertnerDelphine GarrigueThomas GeeraertsSebastien GetteAnne GodierPierre GossetJean-Luc HanouzJean-Denis MoyerOlivier LangeronMarc LeoneJulien PottecherJonathan PortazMathieu RauxMarion ScottoMathieu WilligAlexia Hardy
• Organismes : AP-HP - Hôpital Beaujon Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Centre de recherche en épidémiologie et santé des populations Institut Desbrest d'Epidémiologie et de Santé Publique Médecine de précision par intégration de données et inférence causale Institut de Recherche Mathématique de Rennes AP-HP - Hôpital Bicêtre [Le Kremlin-Bicêtre] Université Paris-Saclay Hopital d'instruction des armées Sainte-Anne [Toulon] École du Val de Grâce CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble [GIN] Grenoble Institut des Neurosciences Hopital Saint-Jean-de-Maurienne
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : Importance Hemorrhagic shock is a common cause of preventable death after injury. Vasopressor administration for patients with blunt trauma and hemorrhagic shock is often discouraged. Objective To evaluate the association of early norepinephrine administration with 24-hour mortality among patients with blunt trauma and hemorrhagic shock. Design, Setting, and Participants This retrospective, multicenter, observational cohort study used data from 3 registries in the US and France on all consecutive patients with blunt trauma from January 1, 2013, to December 31, 2018. Patients were alive on admission with hemorrhagic shock, defined by prehospital or admission systolic blood pressure less than 100 mm Hg and evidence of hemorrhage (ie, prehospital or resuscitation room transfusion of packed red blood cells, receipt of emergency treatment for hemorrhage control, transfusion of >10 units of packed red blood cells in the first 24 hours, or death from hemorrhage). Blunt trauma was defined as any exposure to nonpenetrating kinetic energy, collision, or deceleration. Statistical analysis was performed from January 15, 2021, to February 22, 2022. Exposure Continuous administration of norepinephrine in the prehospital environment or resuscitation room prior to hemorrhage control, according to European guidelines. Main Outcomes and Measures The primary outcome was 24-hour mortality, and the secondary outcome was in-hospital mortality. The average treatment effect (ATE) of early norepinephrine administration on 24-hour mortality was estimated according to the Rubin causal model. Inverse propensity score weighting and the doubly robust approach with 5 distinct analytical strategies were used to determine the ATE. Results A total of 52 568 patients were screened for inclusion, and 2164 patients (1508 men [70%]; mean [SD] age, 46 [19] years; median Injury Severity Score, 29 [IQR, 17-36]) presented with acute hemorrhage and were included. A total of 1497 patients (69.1%) required emergency hemorrhage control, 128 (5.9%) received a prehospital transfusion of packed red blood cells, and 543 (25.0%) received a massive transfusion. Norepinephrine was administered to 1498 patients (69.2%). The 24-hour mortality rate was 17.8% (385 of 2164), and the in-hospital mortality rate was 35.6% (770 of 2164). None of the 5 analytical strategies suggested any statistically significant association between norepinephrine administration and 24-hour mortality, with ATEs ranging from –4.6 (95% CI, –11.9 to 2.7) to 2.1 (95% CI, –2.1 to 6.3), or between norepinephrine administration and in-hospital mortality, with ATEs ranging from –1.3 (95% CI, –9.5 to 6.9) to 5.3 (95% CI, –2.1 to 12.8). Conclusions and Relevance The findings of this study suggest that early norepinephrine infusion was not associated with 24-hour or in-hospital mortality among patients with blunt trauma and hemorrhagic shock. Randomized clinical trials that study the effect of early norepinephrine administration among patients with trauma and hypotension are warranted to further assess whether norepinephrine is safe for patients with hemorrhagic shock.

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Fichiers liés : gauss_2022_oi_220977_1664506622.06301.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/10/2022
• Auteurs : Anjali AjayakumarJekabs RomansMartial AuthierYazeed BalasmehAlexandre BrizardFrederic BoumardLucia CaceresJean-Francois CamArno ClaessensSamuel DamoyPierre DelahayePhilippe DesruesWenling DongAntoine DrouartPatricia DuchesneRafael FerrerXavier FléchardSerge FranchooPatrice GangnantSarina GeldhofRuben P de GrooteFedor IvandikovNathalie LecesneRenan LeroyJulien LoryFranck LuttonV. ManeaYvan MerrerIain MooreAlejandro Ortiz-CortesBenoit OsmondJulien PiotOlivier PochonSebastian RaederA. de RoubinHervé SavajolsDominik StuderEmil TraykovJuha UusitaloChristophe VandammePaul van den BerghPiet van DuppenKlaus Wendt
• Organismes : Grand Accélérateur National d'Ions Lourds Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique corpusculaire de Caen Grand Accélérateur National d'Ions Lourds Laboratoire de physique corpusculaire de Caen Grand Accélérateur National d'Ions Lourds Laboratoire de physique corpusculaire de Caen Grand Accélérateur National d'Ions Lourds Grand Accélérateur National d'Ions Lourds Laboratoire de physique corpusculaire de Caen Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique corpusculaire de Caen Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Grand Accélérateur National d'Ions Lourds Grand Accélérateur National d'Ions Lourds Grand Accélérateur National d'Ions Lourds Grand Accélérateur National d'Ions Lourds Laboratoire de physique corpusculaire de Caen Grand Accélérateur National d'Ions Lourds Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique corpusculaire de Caen Grand Accélérateur National d'Ions Lourds Grand Accélérateur National d'Ions Lourds Grand Accélérateur National d'Ions Lourds Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Grand Accélérateur National d'Ions Lourds Institut Pluridisciplinaire Hubert Curien Laboratoire de physique corpusculaire de Caen

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Résumé : The Super Separator Spectrometer-Low Energy Branch (Sl. 268 ${}^3$-LEB) is a low-energy radioactive ion beam experiment under commissioning as part of the GANIL-SPIRAL2 facility. It will be used for the production and study of exotic nuclei by in-gas laser ionization and spectroscopy (IGLIS), decay spectroscopy, and mass spectrometry. We report recent results from the off-line commissioning of Sl. 268 ${}^3$-LEB, including first laser spectroscopy measurements in both the gas cell and the supersonic gas jet, the determination of the transport efficiency of laser ions from the gas cell through the RFQ chain, and time-of-flight measurements with the multi-reflection time-of-flight mass spectrometer PILGRIM. The measurements were performed using erbium, introduced by evaporation from a heated filament in the gas environment. The reported laser spectroscopy results include a characterization of the pressure broadening in the gas cell, proof-of-principle isotope shift measurements, and hyperfine-structure measurements.

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Fichiers liés : S0168583X23001003.pdf

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• Type de publi. :
• Date de publi. : 03/10/2022
• Auteurs : Nicolas BalasJean-Philippe Denis
• Organismes : Montpellier Research in Management Université Paris Dauphine-PSL Université Paris-Saclay Réseaux Innovation Territoires et Mondialisation

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Résumé : Xerfi Canal a reçu Nicolas Balas pour parler de l'apport de Bourdieu dans le management. Une interview menée par Jean-Philippe Denis.

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Fichiers liés : Pierre_Bourdieu_auteur_subversif_du_management_Nicolas_Balas_.mp4

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/10/2022
• Auteurs : Martin DentanGianluca BorgeseJean-Luc AutranDaniela MunteanuSoilihi MoindjePhilippe MoreauFrancis-Pierre PellissierBenjamin SantraineJérôme BucalossiPhilippe RocheVictor MalherbeMatteo CecchettoGarcía Alía Rubén
• Organismes : ITER organization ITER organization Institut des Matériaux, de Microélectronique et des Nanosciences de Provence Institut des Matériaux, de Microélectronique et des Nanosciences de Provence Institut des Matériaux, de Microélectronique et des Nanosciences de Provence CEA Cadarache CEA Cadarache CEA Cadarache CEA Cadarache STMicroelectronics [Crolles] STMicroelectronics [Crolles] CERN [Genève] CERN [Genève]

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Résumé : We validated a method for predicting the Soft Error Rate (SER) in the WEST tokamak operated with deuterium plasmas, and we applied it to predict the SER in the ITER tokamak operated with deuterium-tritium plasmas.

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Fichiers liés : Radecs_2022_HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/10/2022
• Auteurs : Francois GouinEberhard StoeckleCharles HonoréMickael RoparsMehrdad JafariJean Camille MatteiAlexandre RochwergerSébastien CarrereDenis WaastGwenaël FerronJean-Christophe MachiavelloPhilippe AnractFrédéric MarchalFrançois SirveauxOren MarcoJérôme GuiramandBrice PaquetteAntonio Di MarcoSylvain CauseretJean-Marc GuilloitPauline SoibinetDimitri TzanisPierre GimberguesFabrice FiorenzaFranck DujardinLouis Le NailJean-Christophe RuzicClaire Chemin-AiriauMagali MorellePierre MéeusMarie KaranianFrançois Le LoarerGualter VazJean-Yves Blay
• Organismes : Centre Léon Bérard [Lyon] Institut Bergonié [Bordeaux] Institut Gustave Roussy Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Hôpital Privé Clairval [Marseille] Aix Marseille Université Marseille medical genetics - Centre de génétique médicale de Marseille Hôpital de la Conception [CHU - APHM] Marseille medical genetics - Centre de génétique médicale de Marseille Hôpital de la Conception [CHU - APHM] Institut de Recherche en Cancérologie de Montpellier Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Toulouse Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] AP-HP - Hôpital Cochin Centre de Recherche en Automatique de Nancy Centre Hospitalier Régional Universitaire de Nancy AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Institut Paoli-Calmettes Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Universitaire [Strasbourg] Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Institut Jean Godinot [Reims] Institut Curie [Paris] Centre Jean Perrin [Clermont-Ferrand] CHU Limoges Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen CHU Trousseau [APHP] CHU Saint-Pierre Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Institut Bergonié [Bordeaux] Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 UNICANCER
• Publié dans BMC Cancer le 01/11/2020

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Résumé : Background: This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods: Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1 margins after initial surgery. Characteristics and treatment comparisons used chi-square for categorical variables and Kruskall-Wallis test for continuous data. Survival distributions were compared in patients reexcised (RE) or not (No-RE) using a log-rank test. A Cox proportional hazard model was used for subgroup analysis. Results: A total of 1,284 patients had experienced initial STS surgery outside NETSARC with R1 margins, including 1,029 patients with second operation documented. Among the latter, 698 patients experienced re-excision, and 331 were not re-excised. Characteristics were significantly different regarding patient age, tumor site, tumor size, tumor depth, and histotype in the population of patients re-excised (RE) or not (No-RE). The study identified RE as an independent favorable factor for OS (HR 0.36, 95%CI 0.23-0.56, p<0.0001), for LRFS (HR 0.45, 95%CI 0.36-0.56, p<0.0001), and for RFS (HR 0.35, 95%CI 0.26-0.46, p<0.0001). Conclusion: This large nationwide series shows that RE improved overall survival in patients with STS of extremities and trunk wall, with prior R1 resection performed outside of a reference center. RE as part of adjuvant care should be systematically considered.

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Fichiers liés : s12885-022-10121-5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/10/2022
• Auteurs : David SulmanMichel ZeitouniJohanne SilvainMathieu KerneïsPaul GuedeneyOlivier BarthélémyDelphine BrugierPierre SabouretBenoît LattucaEmilie MertensJulianne PossonNiki ProcopiTomy SalloumJean-Philippe ColletGilles Montalescot
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital de la Pitié Salpêtrière Groupe Action Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans European Heart Journal - Cardiovascular Pharmacotherapy le 31/10/2019

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Résumé : Aims: The European Society of Cardiology (ESC) has released three consecutive guidelines within 5 years addressing cardiovascular prevention, risk scores, and cholesterol treatment. This study aims to evaluate whether the 2021 ESC guidelines improved the eligibility of individuals for primary prevention statin therapy before their first ST-segment elevation myocardial infarction (STEMI), and for intensive lipid-lowering treatments in secondary prevention. Methods and results: The cardiovascular risk category of 2757 consecutive individuals admitted for a first STEMI was evaluated to assess whether they would have been eligible for primary prevention statins according to 2021 vs. 2019 and 2016 ESC guidelines. Eligibility for intensive lipid-lowering therapy in secondary prevention was assessed according to the real-life follow-up low-density lipoprotein cholesterol (LDL-C) and the expected follow-up LDL-C. More individuals would have been eligible for primary prevention statins according to 2021 and 2019 vs. 2016 guidelines (61.8% vs. 38.7% vs. 23.6%, P < 0.01), a finding observed in both men (62.3% vs. 35.0% vs. 24.9%, P < 0.01) and women (60.2% vs. 50.7% vs. 19.3%, P = 0.18). Only 27% of individuals reached the LDL-C objective of 55 mg/L in secondary prevention: using the ESC stepwise approach, 61.7% were eligible for higher doses of statins, 26.2% for ezetimibe, and 12.1% for a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor (PCSK9i). Based on expected LDL-C reductions, eligibility for a PCSK9i in secondary prevention was greater with 2021 vs. 2016 guidelines (44.5% vs. 22.5%, P < 0.01). Conclusion: The 2021 ESC guidelines improved the detection and treatment of individuals at risk for a first myocardial infarction. In secondary prevention, 70% of patients kept LDL-C levels above 55 mg/dL: increasing the statin dose and adding ezetimibe were the most frequently recommended therapeutic actions.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/10/2022
• Auteurs : Jean FurstossPierre HirelPhilippe CarrezPatrick Cordier
• Organismes : Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Jean-Philip BrugalPhilippe FosseJean-Baptiste FourvelPierre MagniezAudrey RousselA. UzunidisPatricia Valensi
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Gestion des ressources naturelles , environnements et sociétés Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Université Côte d'Azur Instituto Internacional de Investigaciones Prehistóricas de Cantrabria [Santander] Laboratoire méditerranéen de préhistoire Europe-Afrique
• Publié dans Bulletin du Musée d'Anthropologie préhistorique de Monaco le 27/10/2020

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