Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2026
• Auteurs : Astou NdiayeNéhou DioufCoumba FayeAnta SarrJean-Pierre BakhoumDiène Diégane ThiaréDiégane SarrAtanasse ColyPhilippe Giamarchi
• Organismes : Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Alioune Diop de Bambey Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme
• Publié dans Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-...] le 01/11/2020

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Résumé : In this paper, we present the design of a new automatic fluorescence monitoring system (AUTOFLUO) for real-time control of pesticide contamination in natural waters. This system was used to analyse two fluorescent pyrethroid insecticides, phenothrin (PHE) and permethrin (PER), currently used in the Niayes agricultural district in Senegal. The results were then compared with those obtained using the classical fluorescence method (FLUO). The analytical parameters (λex, λem, and pH) were optimised. Phenothrin exhibits maximum excitation and emission wavelengths of 221 and 321 nm, respectively, whereas permethrin has these values at 210 and 297 nm. The optimum pH value was determined to be 7 for PHE and 8 for PER. The linearity of both the calibration and standard addition curves was validated through variance analysis. A Student's t-test demonstrated that the intercept values of the calibration curves were not significantly different from zero (p > 5 %). The limit of detection (LOD) ranges from 0.02 to 5.16 ng mL−1, while the limit of quantification ranges from 0.07 to 17.18 ng mL−1. Comparing these LOD values with those reported in the literature demonstrates the high sensitivity of the AUTOFLUO method. Both insecticides were analysed in spiked natural waters using the standard addition procedure. Satisfactory recovery rates were obtained by the FLUO (88.9 % to 97.6 %) and the AUTOFLUO (95.7 % to 102.8 %) methods. The low intraday and interday relative standard deviations (< 2 % and < 4 % respectively) attest to the repeatability and reproducibility of the measurements. The satisfactory tolerance limits of the interfering species validate the method's selectivity. These results demonstrate that the AUTOFLUO system is suitable for reliably monitoring pesticides in natural waters.

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Fichiers liés : 1-s2.0-S1386142525012235-main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 31/01/2026
• Auteurs : Philippe GardesLaurent CallegarinPierre PéfauWilfried LabartheMickaël Xompero
• Organismes : Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut de recherche sur l'architecture antique Centre National de la Recherche Scientifique Institut de recherche sur l'architecture antique Archeodunum Centre d'études et de recherches archéologiques en Gascogne

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Source

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/01/2026
• Auteurs : Carine CalastrencMarie-Claude BalFrançois BaleuxPierre CampmajoArthur ChironNicolas DobigeonMaialen GauthierLuc LapierreAntoine LaurentMatthieu Le BaillyMuriel LlubesNicolas MelladoBatiste MellierJosu Narbarte HernandesMagali PhilippeNicolas PoirierChristine RenduRomain Vercasson
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Géographie de l'environnement Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Machine Learning Integrity & Safety Fairness Impact Trust Signal et Communications France, Amériques, Espagne, Sociétés, Pouvoirs, Acteurs Société Française de Photogrammétire et de télédétection Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Laboratoire Chrono-environnement (UMR 6249) Géosciences Environnement Toulouse Institut de recherche en informatique de Toulouse Géosciences Environnement Toulouse Universidad del País Vasco [Espania] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Géographie de l'environnement Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Géosciences Environnement Toulouse

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Résumé : Apport du Lidar HD de l'IGN et de la photogrammétrie par drone ✓ 23 années de prospection pédestres ✓ 882 structures inventoriées Apport du Lidar HD de l'IGN

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Fichiers liés : Seminaire_Terrae_30_janvier_2026.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/01/2026
• Auteurs : Carine CalastrencMarie-Claude BalFrançois BaleuxPierre CampmajoArthur ChironNicolas DobigeonMaialen GauthierLuc LapierreAntoine LaurentMatthieu Le BaillyMuriel LlubesNicolas MelladoBastiste MellierJosu Narbarte HernandezMagali PhilippeNicolas PoirierChristine RenduRomain Vercasson
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Géographie de l'environnement Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Machine Learning Integrity & Safety Fairness Impact Trust Signal et Communications Institut National Polytechnique (Toulouse) France, Amériques, Espagne, Sociétés, Pouvoirs, Acteurs Centre National d'Études Spatiales [Toulouse] Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Laboratoire Chrono-environnement (UMR 6249) Géosciences Environnement Toulouse Structural Models and Tools in Computer Graphics Centre National de la Recherche Scientifique Géosciences Environnement Toulouse Universidad del País Vasco [Espania] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Géographie de l'environnement Cités, Territoires, Environnement et Sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Géosciences Environnement Toulouse

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Fichiers liés : Seminaire_Terrae_30_janvier_2026_V2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/01/2026
• Auteurs : Didot Budi PrasetyoThibault VallecilloEva KrupaJulian GratiauxAlicia VolMathieu LoyerJean-Philippe MartinetQuentin Di BrasiKhamsing VongphaylothBruno MathieuSébastien BoyerArezki IzriFrédérick GayJérôme Depaquit
• Organismes : Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Institut Pasteur du Cambodge Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Hôpital universitaire Robert Debré [Reims] Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Écologie et Émergence des Pathogènes Transmis par les Arthropodes / Ecology and Emergence of Arthropod-borne Pathogens Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Institut Jean Godinot [Reims] Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Institut Pasteur du Laos Pathogens Host Arthropod Vectors Interfaces Institut Pasteur du Cambodge Écologie et Émergence des Pathogènes Transmis par les Arthropodes / Ecology and Emergence of Arthropod-borne Pathogens Unité des Virus Emergents CHU Avicenne Institut Pierre Louis d'Epidémiologie et de Santé Publique Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Laboratoire de Parasitologie-Mycologie
• Publié dans Current Research in Parasitology & Vector-Borne Diseases le 25/03/2022

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Résumé : Previously considered a leishmaniasis-free region, Southeast Asia has reported emerging cases over the past 20 years. This has renewed interest in the primary vectors, the phlebotomine sand flies. However, information on these vectors in Southeast Asia, particularly in Cambodia, remains scarce. To update distribution records and assess species diversity, CDC light traps were deployed to collect sand flies at 16 locations across several provinces of Cambodia in 2011 and 2014. A total of 940 sand flies were collected and identified both morphologically and molecularly using cytochrome b as a marker gene. Species identification revealed the presence of four genera and 10 species. The predominant species was Grassomyia sp. (21.9%), followed by Sergentomyia sylvatica (21.4%) and Sergentomyia iyengari Group (16.7%). Generally identified as Grassomyia indica, the Grassomyia specimens found in this study exhibited morphological disparities, although genetic analysis showed homogeneity with Gr. indica from other countries. Sergentomyia iyengari and Sergentomyia barraudi each displayed two distinct groups based on both morphological and genetic analyses, suggesting that different species within these complexes are present in Cambodia. Further investigation of these species complexes is warranted, since genomic evidence suggests the existence of previously undescribed species in this region.

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Fichiers liés : 1-s2.0-S2667114X26000129-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/01/2026
• Auteurs : Long PhanAlice GattiZiwen HanNathaniel LiJosephina HuHugh ZhangSean ShiMichael ChoiAnish AgrawalArnav ChopraAdam KhojaRyan KimJason HausenloyOliver ZhangMantas MazeikaDaron AndersonTung NguyenMobeen MahmoodFiona FengSteven Y. FengHaoran ZhaoMichael YuVarun GangalChelsea ZouZihan WangJessica P. WangPawan KumarOleksandr PokutnyiRobert GerbiczSerguei PopovJohn-Clark LevinMstyslav KazakovJohannes SchmittGeoff GalgonAlvaro SanchezYongki LeeWill YeadonScott SauersMarc RothChidozie AguSøren RiisFabian GiskaSaiteja UtpalaZachary GiboneyGashaw M. GoshuJoan of Arc XavierSarah-Jane CrowsonMohinder Maheshbhai NaiyaNoah BurnsLennart FinkeZerui ChengHyunwoo ParkFrancesco Fournier-FacioJohn WydallisMark NandorAnkit SinghTim GehrungerJiaqi CaiBen MccartyDarling DucloselJungbae NamJennifer ZampeseRyan G. HoerrAras BachoGautier Abou LoumeAbdallah GalalHangrui CaoAlexis C GarretsonDamien SileoQiuyu RenDoru CojocPavel ArkhipovUsman QaziLianghui LiSumeet MotwaniChristian Schroeder de WittEdwin TaylorJohannes VeithEric SingerTaylor D. HartmanPaolo RissoneJaehyeok JinJack Wei Lun ShiChris G. WillcocksJoshua RobinsonAleksandar MikovAmeya PrabhuLongke TangXavier AlapontJustine Leon UroKevin ZhouEmily de Oliveira SantosAndrey Pupasov MaksimovEdward VendrowKengo ZenitaniJulien GuillodYuqi LiJoshua VendrowVladyslav KuchkinNg Ze-AnPierre MarionDenis EfremovJayson LynchKaiqu LiangAndrew GritsevskiyDakotah MartinezBen PagelerNick CrispinoDimitri ZvonkineNatanael Wildner FragaSaeed SooriOri PressHenry TangJulian SalazarSean R. GreenLina BrüsselMoon TwayanaAymeric DieuleveutT. Ryan RogersWenjin ZhangBikun LiJinzhou YangArun RaoGabriel LoiseauMikhail KalininMarco LukasCiprian ManolescuSubrata MishraAriel Ghislain Kemogne KamdoumTobias KreimanTad HoggAlvin JinCarlo BosioGongbo SunBrian P CoppolaTim TarverHaline HeidingerRafael SayousStefan IvanovJoseph M CavanaghJiawei ShenJoseph Marvin ImperialPhilippe SchwallerShaipranesh SenthilkumaAndres M BranAli DehghanAndres AlgabaBrecht VerbekenDavid NoeverRagavendran P VLisa SchutIlia SucholutskyEvgenii ZheltonozhskiiDerek LimRichard StanleyShankar SivarajanTong YangJohn MaarJulian WykowskiMartí OllerJennifer SandlinAnmol SahuYuzheng HuSara FishNasser HeydariArchimedes AprontiKaivalya RawalTobias Garcia VilchisYuexuan ZuMartin LacknerJames KoppelJeremy NguyenDaniil S. AntonenkoSteffi ChernBingchen ZhaoPierrot ArseneAlan GoldfarbSergey IvanovRafał PoświataChenguang WangDaofeng LiDonato CrisostomiAndrea AchilleosBenjamin MyklebustArchan SenDavid PerrellaNurdin KaparovMark H InlowAllen ZangElliott ThornleyDaniil OrelVladislav PoritskiShalev Ben-DavidZachary BergerParker WhitfillMichael FosterDaniel MunroLinh HoDan Bar HavaAleksey KuchkinRobert LauffDavid HolmesFrank SommerhageKeith SchneiderZakayo KazibweNate StambaughMukhwinder SinghIlias MagoulasDon ClarkeDae Hyun KimFelipe Meneguitti DiasVeit ElserKanu Priya AgarwalVictor Efren Guadarrama VilchisImmo KloseChristoph DemianUjjwala AnantheswaranAdam ZweigerGuglielmo AlbaniJeffery LiNicolas DaansMaksim RadionovVáclav RozhoňZiqiao MaChristian StumpMohammed BerkaniJacob PlatnickVolodymyr NevirkovetsLuke BaslerMarco PiccardoFerenc JeanplongNiv CohenJosef TkadlecPaul RosuPiotr PadlewskiStanislaw BarzowskiKyle MontgomeryAline MenezesArkil PatelZixuan WangJamie Tucker-FoltzJack StadeTom GoertzenFereshteh KazemiJeremiah MilbauerJohn Arnold AmbayAbhishek ShuklaYan Carlos Leyva LabradorAlan GivréHew WolffVivien RossbachMuhammad Fayez AzizYounesse KaddarYanxu ChenRobin ZhangJiayi PanAntonio TerpinNiklas MuennighoffHailey SchoelkopfEric ZhengAvishy CarmiAdam JonesJainam ShahEthan D. L. BrownKelin ZhuMax BartoloRichard WheelerAndrew HoShaul BarkanJiaqi WangMartin StehbergerEgor KretovKaustubh SridharZienab El-WasifAnji ZhangDaniel PydaJoanna TamDavid M. CunninghamVladimir GoryachevDemosthenes PatramanisMichael KrauseAndrew RedentiDaniel BugasDavid AldousJesyin LaiShannon ColemanMohsen BahalooJiangnan XuSangwon LeeSandy ZhaoNing TangMichael K. CohenMicah CarrollOrr ParadiseJan Hendrik KirchnerStefan SteinerbergerMaksym OvchynnikovJason O. MatosAdithya ShenoyBenedito Alves de Oliveira JuniorMichael WangYuzhou NiePaolo GiordanoPhilipp PetersenAnna Sztyber-BetleyPriti ShuklaJonathan CrozierAntonella PintoShreyas VermaPrashant JoshiZheng-Xin YongAllison TeeJérémy AndréolettiOrion WellerRaghav SinghalGang ZhangAlexander IvanovSeri KhouryHamid MostaghimiKunvar ThamanQijia ChenTran Quoc KhánhJacob LoaderStefano CavalleriHannah SzlykZachary BrownJonathan RobertsWilliam AlleyKunyang SunRyan StendallMax LamparthAnka ReuelTing WangHanmeng XuSreenivas Goud RaparthiPablo Hernández-CámaraFreddie MartinDmitry MalishevThomas PreuTomek KorbakMarcus AbramovitchDominic WilliamsonZiye ChenBiró BálintM Saiful BariPeyman KassaniZihao WangBehzad AnsarinejadLaxman Prasad GoswamiYewen SunHossam ElgnainyDaniel TorderaGeorge BalabanianEarth AndersonLynna KvistadAlejandro José MoyanoRajat MaheshwariAhmad SakorMurat EronIsaac C. McalisterJavier GimenezInnocent EnyekweAndrew Favre D. O.Shailesh ShahXiaoxiang ZhouFiruz KamalovRonald ClarkSherwin AbdoliTim SantensKhalida MeerHarrison K WangKalyan RamakrishnanEvan ChenAlessandro TomasielloG. Bruno de LucaShi-Zhuo LooiVinh-Kha LeNoam KoltNiels MündlerAvi SemlerEmma RodmanJacob DroriCarl J FossumMilind JagotaRonak PradeepHonglu FanTej ShahJonathan EicherMichael ChenKushal ThamanWilliam MerrillCarter HarrisJason GrossIlya GusevAsankhaya SharmaShashank AgnihotriPavel ZhelnovSiranut UsawasutsakornMohammadreza MofayeziSergei BogdanovAlexander PiperskiMarc CarauleanuDavid K. ZhangDylan LerRoman LeventovIgnat SorokoThorben JansenPascal LauerJoshua DuerschVage TaamazyanWiktor MorakWenjie MaWilliam HeldTran Đuc HuyRuicheng XianArmel Randy ZebazeMohanad MohamedJulian Noah LeserMichelle X YuanLaila YacarJohannes LenglerHossein ShahrtashEdson OliveiraJoseph W. JacksonDaniel Espinosa GonzalezAndy ZouMuthu ChidambaramTimothy ManikHector HaffendenDashiell StanderAli DasouqiAlexander ShenEmilien DucBita GolshaniDavid StapMikalai UzhouAlina Borisovna ZhidkovskayaLukas LewarkMátyás VinczeDustin WehrColin TangZaki HossainShaun PhillipsJiang MuzhenFredrik EkströmAngela HammonOam PatelNicolas RemyFaraz FarhidiGeorge MedleyForough MohammadzadehMadellene PeñaflorHaile KassahunAlena FriedrichClaire SparrowTaom SakalOmkar DhamaneAli Khajegili MirabadiEric HallmanMike BattagliaMohammad MaghsoudimehrabaniHieu HoangAlon AmitDave HulbertRoberto PereiraSimon WeberStephen MensahNathan AndreAnton PeristyyChris HarjadiHimanshu GuptaStephen MalinaSamuel AlbanieWill CaiMustafa MehkaryFrank ReidegeldAnna-Katharina DickCary FridayJasdeep SidhuWanyoung KimMariana CostaHubeyb GurdoganBrian WeberHarsh KumarTong JiangArunim AgarwalChiara CeconelloWarren S. VazChao ZhuangHaon ParkAndrew R. TawfeekDaattavya AggarwalMichael KirchhofLinjie DaiEvan KimJohan FerretYuzhou WangMinghao YanKrzysztof BurdzyLixin ZhangAntonio FrancaDiana T. PhamKang Yong LohJoshua RobinsonShreen GulGunjan ChhablaniZhehang DuAdrian CosmaColin WhiteRobin RibletPrajvi SaxenaJacob VotavaVladimir VinnikovEthan DelaneyShiv HalasyamaniSyed M. ShahidJean-Christophe MourratLavr VetoshkinRenas BachoVincent GinisAleksandr MaksapetyanFlorencia de la RosaXiuyu LiGuillaume MalodLeon LangJulien LaurendeauFatimah AdesanyaJulien PortierLawrence HollomVictor SouzaYuchen Anna ZhouYiğit YalınGbenga Daniel ObikoyaLuca ArnaboldiFilippo BigiKaniuar BachoPierre ClavierGabriel RecchiaMara PopescuNikita ShulgaNgefor Mildred TanwieThomas C. H. LuxBen RankColin NiAlesia YakimchykHuanxu LiuOlle HäggströmEmil VerkamaHimanshu NarayanHans GundlachLeonor Brito-SantanaBrian AmaroVivek VajipeyRynaa GroverYiyang FanGabriel Poesia Reis E SilvaLinwei XinYosi KratishJakub ŁuckiWen-Ding LiJustin XuKevin Joseph ScariaFreddie VargusFarzad HabibiEmanuele RodolàJules RobinsVincent ChengDeclan GrabbIda BosioTony FruhauffIdo AkovEve J. Y. LoHao QiXi JiangBen SegevJingxuan FanSarah MartinsonErik Y. WangKaylie HausknechtMichael P. BrennerMao MaoYibo JiangXinyu ZhangDavid AvagianEshawn Jessica ScipioMuhammad Rehan SiddiqiAlon RagolerJustin TanDeepakkumar PatilRebeka PlecnikAaron KirtlandRoselynn Grace MontecilloStephane DurandOmer Faruk BodurZahra AdoulMohamed ZekryGuillaume DouvilleAli KarakocTania C. B. SantosSamir ShamseldeenLoukmane KarimAnna LiakhovitskaiaNate ResmanNicholas FarinaJuan Carlos GonzalezGabe MaayanSarah HobackRodrigo de Oliveira PenaGlen ShermanHodjat MarijiRasoul PouriamaneshWentao WuGözdenur DemirSandra MendozaIsmail AlarabJoshua ColeDanyelle FerreiraBryan JohnsonHsiaoyun MillironMohammad SafdariLiangti DaiSiriphan ArthornthurasukAlexey ProninJing FanAngel Ramirez-TrinidadAshley CartwrightDaphiny PottmaierOmid TaheriDavid OutevskyStanley StepanicSamuel PerryLuke AskewRaúl Adrián Huerta RodríguezAbdelkader DendaneSam AliRicardo LorenaKrishnamurthy IyerSk Md SalauddinMurat IslamJuan GonzalezJosh DuceyRussell CampbellMaja SomrakVasilios MavroudisEric VergoJuehang QinBenjámin BorbásEric ChuJack LindseyAnil RadhakrishnanAntoine JallonI. M. J. McinnisAlex HooverSören MöllerSong BianJohn LaiTejal PatwardhanSummer YueAlexandr WangDan Hendrycks
• Organismes : Center for AI Safety Center for AI Safety Scale AI Center for AI Safety Scale AI Scale AI Scale AI Scale AI Scale AI Center for AI Safety Center for AI Safety Center for AI Safety Center for AI Safety Centre Inria de l'Université de Lille Laboratoire Jacques-Louis Lions Département de Mathématiques et Applications - ENS-PSL (UMR8553) Numerical Analysis, Geophysics and Ecology Machine Learning in Information Networks Laboratoire de Mathématiques d'Orsay Ecole Normale Supérieure Paris-Saclay Automatic Language Modelling and ANAlysis & Computational Humanities Systèmes complexes, automates et pavages Ecole Normale Supérieure Paris-Saclay Unité de Mathématiques Pures et Appliquées Centre de Mathématiques Appliquées de l'Ecole polytechnique Scale AI Scale AI Center for AI Safety
• Publié dans Nature le 29/10/2020

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Résumé : Benchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping pace in difficulty: LLMs now achieve more than 90% accuracy on popular benchmarks such as Measuring Massive Multitask Language Understanding1, limiting informed measurement of state-of-the-art LLM capabilities. Here, in response, we introduce Humanity’s Last Exam (HLE), a multi-modal benchmark at the frontier of human knowledge, designed to be an expert-level closed-ended academic benchmark with broad subject coverage. HLE consists of 2,500 questions across dozens of subjects, including mathematics, humanities and the natural sciences. HLE is developed globally by subject-matter experts and consists of multiple-choice and short-answer questions suitable for automated grading. Each question has a known solution that is unambiguous and easily verifiable but cannot be quickly answered by internet retrieval. State-of-the-art LLMs demonstrate low accuracy and calibration on HLE, highlighting a marked gap between current LLM capabilities and the expert human frontier on closed-ended academic questions. To inform research and policymaking upon a clear understanding of model capabilities, we publicly release HLE at https://lastexam.ai.

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Fichiers liés : s41586-025-09962-4.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/01/2026
• Auteurs : Andréa Clément de GivryPauline ManchonMarianne VeyriJulie DelyonNausicaa MalissenCaroline Gaudy-MarquesteOuidad ZehouArnaud JannicEmilie GérardNora KramkimelChristine LongvertEve MaubecMarie BoileauPierre-Emmanuel StoebnerHenri MontaudiéGaëlle QuéreuxJean-Matthieu l'OrphelinElodie PoirierCéline GirardCharlée NardinLaurent MortierValentine-Marie FerréVincent DescampsJean-Philippe SpanoCédric LaouénanJade GhosnCéleste LebbéFlorence Brunet-Possenti
• Organismes : AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique Institut Pierre Louis d'Epidémiologie et de Santé Publique AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital Saint-Louis [Paris] Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM] Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM] AP-HP - Hôpital Henri-Mondor Centre Hospitalier Intercommunal de Créteil Hôpital Pellegrin AP-HP - Hôpital Cochin AP-HP - Hôpital Ambroise Paré AP-HP - Hôpital Avicenne Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Nîmes Institut de Recherche en Cancérologie de Montpellier Service de Dermatologie [Nice] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Groupe Hospitalier Paris Saint-Joseph Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Régional Universitaire [CHU Lille] Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital de la Pitié Salpêtrière Infection, Anti-microbiens, Modélisation, Evolution Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Saint-Louis [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution
• Publié dans Oncologist le 26/10/2020

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Résumé : Background: People living with HIV (PWH) have an increased risk of developing aggressive skin cancers, yet they have been largely excluded from immune checkpoint inhibitor (ICI) trials. Consequently, evidence on the safety and efficacy of ICIs in this population remains scarce, particularly for the nivolumab plus ipilimumab (NIVO+IPI) combination. Methods: This multicentre, real-world study included PWH treated with ICIs for melanoma or non-melanoma skin cancers. The objective was to evaluate patient characteristics, treatment management, and clinical outcomes across the different skin cancer types. Results: Among the 54 patients, 89% were male, and 92.6% had a suppressed HIV viral load. Melanoma was the most frequent tumour (35/54, 64.8%), followed by cutaneous squamous cell carcinoma (12/54, 22.2%), Kaposi sarcoma (4/54, 7.4%), basal cell carcinoma (2/54, 3.7%), and one Merkel cell carcinoma. Anti-PD-1/PD-L1 monotherapy was given as first-line treatment in 81.5% (44/54). Immune-related adverse events (irAEs) occurred in 42.6% (23/54), with a median onset of 43.5 days (IQR, 20.5–126). The maximum toxicity grade was 1/2 in 39% (21/54), grade ≥ 3 in 13% (7/54). Seventeen melanoma patients received NIVO+IPI. Among them, 64.7% (11/17) experienced irAEs, including grade ≥ 3 events in 30% (5/17). Objective response rates were 43% (9/21) in melanoma, 58% (7/12) in cSCC, and 75% (3/4) in Kaposi sarcoma. Conclusions: PWH treated with ICIs for skin cancer demonstrated favourable outcomes, with a notably reassuring safety profile of NIVO+IPI. These findings support managing well-controlled PWH similarly to the general population and highlight the importance of including this population across all settings of skin cancer trials.

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Fichiers liés : oyaf419.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/01/2026
• Auteurs : Milène FréneauRaphaël BlanchetMaxence BodetSandro BenichiMary-Adel MradSurya Prakash Rao BattaMarc RioStéphanie BonnaudPierre LindenbaumFabien LaporteStéphane CuénotThibaut QuillardMike MaillassonSandrine MorelBrenda R KwakPhilippe BijlengaJean‐françois DeleuzeChristian DinaStéphanie ChatelEmmanuelle BourcereauSolène JouanArturo ConsoliCyril DargazanliJulien OgnardHubert DesalAnne-Clémence VionRomain BourcierGervaise LoirandRichard Redon
• Organismes : ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Institut des Matériaux de Nantes Jean Rouxel ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 BioCore [Nantes] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva Université de Genève = University of Geneva Université de Genève = University of Geneva Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Centre National de Recherche en Génomique Humaine ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Versailles Saint-Quentin-en-Yvelines Hôpital Foch [Suresnes] CHU Montpellier = Montpellier University Hospital Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
• Publié dans Cardiovascular Research le 29/10/2020

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Résumé : AimsIntracranial aneurysm (IA) is a common cerebrovascular abnormality characterized by localized dilation and wall thinning in cerebral arteries, which can rupture and lead to fatal subarachnoid haemorrhage. Although genetic factors can contribute to IA, the genetic pre-disposition of IA is largely unknown. This study aims to identify rare functional variants associated with IA in families with multiple affected subjects and explore their impact on IA pathophysiology.Methods and resultsBy combining whole-exome sequencing and identity-by-descent analyses, we have identified two rare missense variants in the CTSO gene associated to IA in two large families with multiple affected subjects. We found that the cysteine-type papain-like cathepsin O (CTSO) encoded by CTSO is expressed in the circle of Willis of mice and in the wall of human IA domes. Stretching of vascular smooth muscle cells (VSMC) induced CTSO secretion. CTSO controls VSMC migration and adhesion to the extracellular matrix, and directly interacts with fibronectin (FN). CTSO depletion, or expression of the two CTSO variants, which are poorly secreted, increased the amount of FN. Moreover, CTSO depletion augmented VSMC stiffness, which was reduced by the addition of exogenous CTSO.ConclusionCollectively, our findings identify CTSO as a potential new player in arterial remodelling, regulating FN deposition and VSMC function, supporting the causal role of rare coding CTSO variants in familial forms of IA.

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Fichiers liés : cvaf279.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/01/2026
• Auteurs : Léa ClabeauVirginie MoulierBastien KaczmarekMarine DalmontJean-Marie BatailNoomane BouazizJérôme BrunelinBenjamin CalvetChristophe DaudetSonia DollfusPhilippe DomenechDominique DrapierFilipe GalvãoB.GohierGhina Harika-GermaneauJérôme HoltzmannNematollah JaafariIsabelle JalenquesDominique JanuelFrançois KazourAndrew LaurinFlorian LetourneurArnaud PouchonLudovic SamalinAnne SauvagetDavid SzekelyFabien VinckierCamille Le ClézioVincent CompèreEmmanuel GerardinOlivier GuillinPierre QuesadaMaud Rothärmel
• Organismes : Centre Hospitalier du Rouvray Centre Hospitalier du Rouvray Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Fédération Hospitalo-Universitaire Améliorer le pronostic des troubles Addictifs et Mentaux par une Médecine Personnalisée CHU Rouen Centre Hospitalier du Rouvray Centre Hospitalier Guillaume Régnier [Rennes] Stanford University Fondation FondaMental [Créteil] Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Centre Hospitalier le Vinatier [Bron] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Université Claude Bernard Lyon 1 Epidémiologie des Maladies Chroniques en zone tropicale Centre Hospitalier Esquirol [Limoges] Université de Bordeaux CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Physiopathologie et imagerie des troubles neurologiques Université de Caen Normandie Fédération Hospitalo-Universitaire Améliorer le pronostic des troubles Addictifs et Mentaux par une Médecine Personnalisée AP-HP - Centre Hospitalier Sainte-Anne IFR49 - Neurospin - CEA Centre Hospitalier Guillaume Régnier [Rennes] Centre d'Investigation Clinique [Rennes] Centre Hospitalier le Vinatier [Bron] Centre Hospitalier Universitaire d'Angers Laboratoire de Psychologie des Pays de la Loire Centre Hospitalier Henri Laborit [Poitiers] Centre de recherches sur la cognition et l'apprentissage [Poitiers, Tours] Université de Poitiers = University of Poitiers CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Henri Laborit [Poitiers] Université de Poitiers = University of Poitiers CHU Clermont-Ferrand Institut Pascal Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Fondation FondaMental [Créteil] Centre Hospitalier Universitaire d'Angers Imaging, Brain & Neuropsychiatry Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Université de Caen Normandie Fédération Hospitalo-Universitaire Améliorer le pronostic des troubles Addictifs et Mentaux par une Médecine Personnalisée CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Dynamique et Structure du Cytosquelette Neuronal Université Grenoble Alpes CHU Clermont-Ferrand Institut Pascal Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Princesse Grace [Monaco] AP-HP - Centre Hospitalier Sainte-Anne Institut du Cerveau = Paris Brain Institute Cancer and Brain Genomics CHU Rouen Université de Rouen Normandie Normandie Université CHU Rouen Analyse intégrée multimodale en santé CHU Rouen Normandie Université Centre Hospitalier du Rouvray CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Normandie Université Fédération Hospitalo-Universitaire Améliorer le pronostic des troubles Addictifs et Mentaux par une Médecine Personnalisée Centre Hospitalier du Rouvray Centre Hospitalier du Rouvray Normandie Université CHU Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Fédération Hospitalo-Universitaire Améliorer le pronostic des troubles Addictifs et Mentaux par une Médecine Personnalisée
• Publié dans Trials le 31/10/2020

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Résumé : Major depressive disorder is a leading cause of disability worldwide, with treatment-resistant depression (TRD) affecting approximately one-third of patients and leading to increased morbidity and healthcare costs. Electroconvulsive therapy (ECT) remains a key treatment for TRD, but its efficacy is limited, and it is associated with cognitive side effects and delayed symptom relief. Repetitive transcranial magnetic stimulation (rTMS) shares action mechanisms with ECT and has shown potential in enhancing ECT efficacy in a previous trial. The STIMAGNECT 2 trial aims to evaluate whether an rTMS add-on protocol can improve ECT outcomes in TRD patients after 10 ECT sessions. Methods: Eighty patients with TRD will be enrolled in a prospective multicentric double-blind randomized controlled trial. All patients will receive a total of 10 ECT sessions. Patients will be randomly assigned to an active or sham rTMS arm. The rTMS protocol (either active or sham) consists of 5 rTMS sessions over 4 days before the beginning of the ECT protocol, with an additional rTMS session the day before each ECT session from the 6th ECT session onward. The main outcome is the response rate following 10 ECT sessions, defined as the proportion of patients achieving a ≥ 50% reduction in their Hamilton Depression Rating Scale (HAMD, 21 items). Secondary outcomes include changes in depression severity (HAMD and QIDS-SR-16) at baseline, during the protocol (Day 4, Day 19, Day 26) and at the end of the protocol, as well as assessment of side effects (adapted UKU), cognitive function (memory, attention, visuospatial abilities, subjective cognitive complaint), autobiographical memory (TEMPau), and ECT session parameters such as seizure characteristics and anesthetic doses. Additionally, potential changes in regional gray matter density, cortical thickness, brain connectivity, and GABA levels will be compared between groups using several magnetic resonance imaging (MRI) sequences (3D, resting-state functional MRI, magnetic resonance spectroscopy). Discussion: The aim of this trial is to optimize neurostimulation protocols using the synergistic effects of rTMS and ECT in order to improve the treatment of TRD.

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Fichiers liés : s13063-025-09406-4.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/01/2026
• Auteurs : Jean-Michel LettSarah ScusselSélim Ben ChéhidaMurielle HoareauDenis FillouxEmmanuel FernandezPhilippe RoumagnacEvelyne ParvedyElise QuirinClarisse ClainJanice MinatchyEstelle RouxPierre-Yves TeycheneyPierre Lefeuvre
• Organismes : Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Plant Health Institute of Montpellier Plant Health Institute of Montpellier Fédération départementale des groupements de défense contre les organismes nuisibles SCA Fruits de La Réunion Fédération départementale des groupements de défense contre les organismes nuisibles Fédération départementale des groupements de défense contre les organismes nuisibles Fédération départementale des groupements de défense contre les organismes nuisibles Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical
• Publié dans Archives of Virology le 27/10/2020

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Résumé : Using unbiased high-throughput sequencing for metagenomic screening of viruses in diseased tomato plants, we identified a viral complex that includes viruses previously reported in tomato crops on La Réunion Island as well as a novel polerovirus, tentatively named "tomato necrotic yellowing virus" (ToNYV, proposed species, "Polerovirus ToNYV"). Molecular characterization and phylogenetic analysis revealed that ToNYV is closely related to two recently described poleroviruses from Africa and the Middle East, one of which is transmitted by the whitefly Bemisia tabaci, a trait uncommon among poleroviruses. Our transmission experiments demonstrated that ToNYV is also transmitted by B. tabaci and is prevalent across major tomato-growing regions of La Réunion. These findings highlight the value of metagenomic virome analysis in diseased plants for identifying novel viruses potentially involved in emerging plant diseases, either individually or as components of viral complexes.

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Fichiers liés : s00705-025-06426-y.pdf

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