Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Florence Laigle-DonadeyPhilippe MetellusJacques GuyotatPhilippe MeneiFrançois ProustHenry DufourOlivier ChinotJérôme HonnoratThierry FaillotPhilippe PaquisPhilippe PeruzziEvelyne EmeryJean-Sébastien GuillamoAlexandre CarpentierMichel WagerSaid LebbahDavid HajageJean-Yves DelattrePhilippe Cornu
• Organismes : AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital de la Pitié Salpêtrière Hôpital Privé Clairval [Marseille] Hospices Civils de Lyon Centre Hospitalier Universitaire d'Angers Hôpital Charles Nicolle [Rouen] Institut Marseille Maladies Rares Hôpital de la Timone [CHU - APHM] Institut NeuroMyoGène Hospices Civils de Lyon AP-HP - Hôpital Beaujon Département de Neurochirurgie [Hôpital Pasteur de Nice] Service de neurologie [Reims] Service de Neurochirurgie [CHU Caen] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie AP-HP - Hôpital de la Pitié Salpêtrière Sorbonne Université Centre hospitalier universitaire de Poitiers = Poitiers University Hospital AP-HP - Hôpital de la Pitié Salpêtrière Institut Pierre Louis d'Epidémiologie et de Santé Publique AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital de la Pitié Salpêtrière
• Publié dans Journal of Neurosurgery le 26/10/2020

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Résumé : OBJECTIVE The role of surgery in the treatment of malignant gliomas in the elderly is not settled. The authors conducted a randomized trial that compared tumor resection with biopsy only—both followed by standard therapy—in such patients. METHODS Patients ≥ 70 years of age with a Karnofsky Performance Scale (KPS) score ≥ 50 and presenting with a radiological suspicion of operable glioblastoma (GBM) were randomly assigned between tumor resection and biopsy groups. Subsequently, they underwent standard radiotherapy during the first years of the trial (2008–2017), with the addition of adjunct therapy with temozolomide when this regimen became standard (2017–2019). The primary endpoint was survival, and secondary endpoints were progression-free survival (PFS), cognitive status (Mini-Mental State Examination), autonomy (KPS), quality of life (European Organisation for Research and Treatment of Cancer [EORTC] QLQ-C30 and QLQ-BN20), and perioperative morbidity and mortality. RESULTS Between 2008 and 2019, 107 patients from 9 centers were enrolled in the study; 101 were evaluable for analysis because a GBM was histologically confirmed (50 in the surgery arm and 51 in the biopsy arm). There was no statistically significant difference in median survival between the surgery (9.37 months) and the biopsy (8.96 months, p = 0.36) arms (adjusted HR 0.79, 95% CI 0.52–1.21, p = 0.28). However, the surgery group had an increased PFS (5.06 vs 4.02 months; p = 0.034) (adjusted HR 0.50, 95% CI 0.32–0.78, p = 0.002). Less deterioration of quality of life and KPS score evolution than in the biopsy group was observed. Surgery was not associated with increased mortality or morbidity. CONCLUSIONS This study suggests that debulking surgery is safe, and, compared to biopsy, is associated with a less severe deterioration of QOL and autonomy and, a significant although modest improvement of PFS in elderly patients suffering from newly diagnosed malignant glioma. Although resection does not provide a significant survival benefit in the elderly, we believe that the risk/benefit analysis favors an attempt at optimal tumor resection in this population, providing careful preoperative geriatric evaluation.

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Fichiers liés : Laigle-Donadey CSA MANUSCRIPT REVISED 01 08 2022 VF_modif acceptees.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Madjid MorsliAgathe BoudetQuentin KerharoRobin StephanFlorian SalipanteCatherine Dunyach-RemyLinda HouhamdiPierre-Edouard FournierJean-Philippe LavigneMichel Drancourt
• Organismes : Microbes Evolution Phylogénie et Infections Hôpital Universitaire de Réadaptation, de Rééducation et d'Addictologie du CHU de Nîmes [Grau-du-Roi] Virulence Bactérienne et Infections Chroniques Institut Hospitalier Universitaire Méditerranée Infection Centre Hospitalier Universitaire de Nîmes BIO-RAD Hôpital Universitaire Carémeau [Nîmes] Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nîmes Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections
• Publié dans EBioMedicine le 28/10/2020

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Résumé : Background: Point-Of-Care (POC) diagnosis of life-threatening community-acquired meningitis currently relies on multiplexed RT-PCR assays, that lack genotyping and antibiotic susceptibility profiling. We assessed the usefulness of real-time metagenomics (RTM) directly applied to the cerebrospinal fluid (CSF) for the identification, typing and susceptibility profiling of pathogens responsible for community-acquired meningitis. Methods: A series of 52 CSF samples from patients suspected of having community-acquired meningitis, were investigated at POC by direct RTM in parallel to routine real-time multiplex PCR (RT-PCR) and bacterial culture, for the detection of pathogens. RTM-generated sequences were blasted in real-time against an in-house database incorporating the panel of 12 most prevalent pathogens and against NCBI using EPI2ME online software, for pathogen identification. In-silico antibiogram and genotype prediction were determined using the ResFinder bio-tool and MLST online software. Findings: Over eight months, routine multiplex RT-PCR yielded 49/52 positive CSFs, including 21 Streptococcus pneumoniae, nine Neisseria meningitidis, eight Haemophilus influenzae, three Streptococcus agalactiae, three Herpesvirus-1, two Listeria monocytogenes, and one each of Escherichia coli, Staphylococcus aureus and Varicella-Zoster Virus. Parallel RTM agreed with the results of 47/52 CSFs and revealed two discordant multiplex RT-PCR false positives, one H. influenzae and one S. pneumoniae. Both multiplex RT-PCR and RTM agreed on the negativity of three CSFs. While multiplex RT-PCR routinely took 90 min, RTM took 120 min, although the pipeline analysis detected the pathogen genome after 20 min of sequencing in 33 CSF samples; and after two hours in 14 additional CSFs; yielding> 50% genome coverage in 19 CSFs. RTM identified 14 pathogen genotypes, including a majority of H. influenzae b, N. meningitidis B and S. pneumoniae 11A and 3A. In all 16 susceptible cultured bacteria, the in-silico antibiogram agreed with the in-vitro antibiogram in 10 cases, available within 48 h in routine bacteriology. Interpretation: In addition to pathogen detection, RTM applied to CSF samples offered supplementary information on bacterial profiling and genotyping. These data provide the proof-of-concept that RTM could be implemented in a POC laboratory for one-shot diagnostic and genomic surveillance of pathogens responsible for life-threatening meningitis.

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Fichiers liés : 1-s2.0-S2352396422004297-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Pierre-Alexandre LeziartThomas CorbèresThomas FlayolsSteve TonneauNicolas MansardPhilippe Souères
• Organismes : Équipe Mouvement des Systèmes Anthropomorphes The University of Edinburgh Équipe Mouvement des Systèmes Anthropomorphes The University of Edinburgh Équipe Mouvement des Systèmes Anthropomorphes Équipe Mouvement des Systèmes Anthropomorphes
• Publié dans IEEE Robotics and Automation Letters le 02/11/2020

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Résumé : This paper presents significant improvements to the nominal control architecture of the open-access Solo-12 quadruped that were done to implement and compare different centroidal Model Predictive Controllers (MPC). This work was motivated by our previous study in which various MPC schemes of increasing complexity were tested in simulation. They range from a simplified linearized model with contact points fixed by a heuristic, to a nonlinear one that also optimizes the contact points locations. We describe the developments that were necessary to implement such control schemes on the real robot while doubling its maximum velocity. Notably, to synthesize a stable whole-body controller, the inverse dynamics resolution was replaced by a mixed inverse kinematics and quadratic programming scheme. These developments enabled the successful deployments of the various centroidal MPCs on Solo-12. Experimental results show that all MPCs lead to quite similar performances with the proposed whole-body controller and, as a consequence, do not confirm the result of previous simulation study that concluded on the preeminence of the nonlinear centroidal MPC optimizing both the center of mass trajectory and the foot placements.

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Fichiers liés : leziart2022_Improved_Control_Scheme_Solo_Quadruped.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : William EscandeJean-Baptiste GourraudMichel HaissaguerreEstelle GandjbakhchThomas LavergneRaphaël P MartinsGhassen ChenitiPhilipp KrisaiJean-Sylvain HermidaPhilippe MauryJose-Louis MerinoJean-Luc PasquiéNicolas CombesElodie SurgetJosselin DuchâteauThomas PambrunNicolas DervalMeleze HociniPierre JaïsTakeshi AibaKoonlawee NademaneeEd VigmondOlivier BernusFrederic SacherVincent Probst
• Organismes : IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] IHU-LIRYC AP-HP - Hôpital de la Pitié Salpêtrière Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases AP-HP - Hôpital Européen Georges Pompidou Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] University Hospital Basel [Basel] Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Centre Hospitalier Universitaire de Toulouse Hospital Universitario La Paz-Carlos III [Madrid] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Clinique Pasteur [Toulouse] IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] IHU-LIRYC IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] IHU-LIRYC IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Amsterdam University Medical Centers Chulalongkorn University [Bangkok] IHU-LIRYC Institut de Mathématiques de Bordeaux Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] IHU-LIRYC ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
• Publié dans Heart Rhythm le 26/10/2020

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Résumé : Background: Sodium channel blocker (SCB) infusion is used to unmask the electrocardiographic pattern of Brugada syndrome. The test may also induce premature ventricular complexes (PVCs) in individuals without Brugada pattern, the clinical relevance of which is little known.Objective: The purpose of this study was to describe the prevalence of short-coupled (Sc) PVCs induced by ajmaline or flecainide in patients with suspected or documented severe ventricular arrhythmias.Methods: We reviewed the SCB tests performed in 335 patients with suspected ventricular arrhythmias and structurally normal hearts in 9 centers. ScPVCs were defined as frequent and repetitive PVCs with an R-on-T pattern on SCB tests. Repeated SCB tests were performed in 7 patients and electrophysiological mapping of ScPVCs in 9.Results: Sixteen patients (8 men; mean age 36 ± 11 years) showed ScPVCs and were included. ScPVCs appeared 229 ± 118 seconds after the initiation of infusion and displayed coupling intervals of 288 ± 28 ms. ScPVC patterns were monomorphic in 12 patients, originating from the Purkinje system in mapped patients. Repetitive PVCs were induced in 15 patients (94%) including polymorphic ventricular tachycardias in 9 (56%). SCB infusion was repeated 45 (interquartile range 0.6-46) months later and induced identical ScPVC in all. SCB test was the only mean to reveal the malignant arrhythmia in 6 patients. Catheter ablation was performed in 9 patients, resulting in arrhythmia elimination in 8 with a follow-up of 6 (interquartile range 2-9) years.Conclusion: SCB can induce ScPVC, mostly from Purkinje tissue, in a small subset of patients with idiopathic ventricular arrhythmias. Its high reproducibility suggests a distinct individual mechanism.

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Fichiers liés : 2022 Escandre et al., Malignant.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : M. ScardiaJean-Louis PrieurJosefina LingL. PansecchiR. ArgyleEric AristidiA. ZanuttaL. AbbePhilippe BendjoyaJean-Pierre RivetDavid VernetLuca Maccarini
• Organismes : INAF - Osservatorio Astronomico di Brera Institut de recherche en astrophysique et planétologie Universidade de Santiago de Compostela [España] = University of Santiago de Compostela [Spain] = Université de Saint-Jacques-de-Compostelle [Espagne] INAF - Osservatorio Astronomico di Brera Laboratoire Hippolyte Fizeau Université Nice Sophia Antipolis (1965 - 2019)
• Publié dans Information Circular - IAU Commission G1 Double Stars le 09/11/2019

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Fichiers liés : cir208.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Pierre DeharoLionel LerouxAlexis ThéronJérôme FerraraAntoine VaillierNicolas JaussaudAlizée PortoPierre MoreraVlad GariboldiBernard IungThierry LefevrePhilippe CommeauMargaux GouysseFlorence Du ChaylaNicolas GlattGuillaume CaylaHervé Le BretonHakim BenamerSylvain BeurtheretJean-Philippe VerhoyeHélène EltchaninoffMartine GilardJean-Philippe ColletNicolas DumonteilFrédéric CollartThomas ModineThomas Cuisset
• Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Hôpital de la Timone [CHU - APHM] Aix-Marseille Université - École de médecine Médico-Chirurgical de Valvulopathies et Cardiomyopathies, Chirurgie Cardiaque Adulte, Cardiologie Interventionnelle Structurelle Adulte [CHU Bordeaux] Département de Cardiologie [Hôpital de la Timone - APHM] Département de Cardiologie [Hôpital de la Timone - APHM] Département de Cardiologie [Hôpital de la Timone - APHM] Département de Cardiologie [Hôpital de la Timone - APHM] Département de Cardiologie [Hôpital de la Timone - APHM] Département de Cardiologie [Hôpital de la Timone - APHM] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Aix-Marseille Université - École de médecine Département de Cardiologie [Hôpital de la Timone - APHM] Service de cardiologie [CHU Bichat] Laboratoire de Recherche Vasculaire Translationnelle Hôpital Privé Jacques Cartier [Massy] Polyclinique Les Fleurs - ELSAN Clinityx Clinityx Clinityx Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hôpital Privé Jacques Cartier [Massy] Hôpital Saint-Joseph [Marseille] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Service de Cardiologie [CHU Rouen] Hôpital de la Cavale Blanche - CHRU Brest Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Clinique Pasteur [Toulouse] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Aix-Marseille Université - École de médecine Médico-Chirurgical de Valvulopathies et Cardiomyopathies, Chirurgie Cardiaque Adulte, Cardiologie Interventionnelle Structurelle Adulte [CHU Bordeaux] Médico-Chirurgical de Valvulopathies et Cardiomyopathies, Chirurgie Cardiaque Adulte, Cardiologie Interventionnelle Structurelle Adulte [CHU Bordeaux] Département de Cardiologie [Hôpital de la Timone - APHM] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Aix-Marseille Université - École de médecine
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : Background: Transcatheter aortic valve implantation (TAVI) is the preferred treatment for symptomatic severe aortic stenosis (AS) in a majority of patients across all surgical risks. Patients and methods: Paravalvular leak (PVL) and patient–prosthesis mismatch (PPM) are two frequent complications of TAVI. Therefore, based on the large France-TAVI registry, we planned to report the incidence of both complications following TAVI, evaluate their respective risk factors, and study their respective impacts on long-term clinical outcomes, including mortality. Results: We identified 47,494 patients in the database who underwent a TAVI in France between 1 January 2010 and 31 December 2019. Within this population, 17,742 patients had information regarding PPM status (5138 with moderate-to-severe PPM, 29.0%) and 20,878 had information regarding PVL (4056 with PVL ≥ 2, 19.4%). After adjustment, the risk factors for PVL ≥ 2 were a lower body mass index (BMI), a high baseline mean aortic gradient, a higher body surface area, a lower ejection fraction, a smaller diameter of TAVI, and a self-expandable TAVI device, while for moderate-to-severe PPM we identified a younger age, a lower BMI, a larger body surface area, a low aortic annulus area, a low ejection fraction, and a smaller diameter TAVI device (OR 0.85; 95% CI, 0.83–0.86) as predictors. At 6.5 years, PVL ≥ 2 was an independent predictor of mortality and was associated with higher mortality risk. PPM was not associated with increased risk of mortality. Conclusions: Our analysis from the France-TAVI registry showed that both moderate-to-severe PPM and PVL ≥ 2 continue to be frequently observed after the TAVI procedure. Different risk factors, mostly related to the patient’s anatomy and TAVI device selection, for both complications have been identified. Only PVL ≥ 2 was associated with higher mortality during follow-up.

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Fichiers liés : jcm-11-06117-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Jorge Lopez-CastromanIsabelle JaussentMartin PastreCarolina Baeza-VelascoJean-Pierre KahnMarion LeboyerEmmanuel DiazPhilippe Courtet
• Organismes : Centre Hospitalier Universitaire de Nîmes Institut de Génomique Fonctionnelle Institut des Neurosciences de Montpellier Centre Hospitalier Universitaire de Nîmes Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier] Laboratoire de Psychopathologie et Processus de Santé Université de Lorraine Institut Mondor de Recherche Biomédicale AP-HP - Hôpital Henri-Mondor Assistance publique - Hôpitaux de Paris Centre Hospitalier Universitaire de Nîmes Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Journal of Psychiatric Research le 26/10/2020

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Résumé : Background: After the Food and Drug Administration alert about antiepileptic medication and suicide, incident epilepsy has been associated with first or recurrent suicide attempts independently of psychiatric comorbidities and antiepileptic treatment. Following this thread, the aim of this study was to analyze if epilepsy was associated with a higher severity of lifetime suicide attempts (SAs).Methods: Analyses were carried out on 1677 adults hospitalized between 1999 and 2012 after a SA in a specialized ward for affective episodes. Five severity features were studied: frequent SAs (>2), early onset of first SA (≤26 years), history of violent SA, high suicide intent and high lethality of the SA. Adjusted logistic regression models were used to estimate the association between the lifetime diagnosis of epilepsy and the severity features.Results: Among suicide attempters, ninety-three patients reported a lifetime diagnosis of epilepsy (5.5%). Epileptic patients diagnosed after the first SA were more likely to be frequent suicide attempters than non-epileptic ones. They showed also higher SA planification scores.Limitations: Diagnosis accuracy is limited by the use of self-reports for epilepsy. The lack of precise information about the disease course and treatment have not allowed for further statistical analysis. With regard to psychiatric comorbidities, personality disorders could not be taken into account.Conclusions: Suicide attempters with epilepsy present an increased severity in some aspects of their suicidal behavior regardless of demographic and clinical variables. Our results give support to the existence of a bidirectional association between epilepsy and suicidal behavior.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Jonas VanardoisPierre TrapRoger FrançoiseJérémie MelletonDidier MarquerJean-Louis PaquettePhilippe GoncalvesFlorence CagnardBenjamin Le Bayon
• Organismes : University of Minnesota System Laboratoire Chrono-environnement (UMR 6249) Géosciences Montpellier Bureau de Recherches Géologiques et Minières University of the Western Cape Laboratoire Chrono-environnement (UMR 6249) Laboratoire Magmas et Volcans Laboratoire Chrono-environnement (UMR 6249) Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières
• Publié dans Journal of Structural Geology le 26/10/2020

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Résumé : The Aiguilles-Rouges and Mont-Blanc massifs represent a segment of a crustal-scale transpressional shear zone named the East Variscan Shear Zone (EVSZ) along which two plutonic pulses occurred during Early and Late Carboniferous times. The aim of this study is to constrain the relationships between the dynamics of the crustal-scale shear zone, the mechanisms of pluton emplacement at different structural levels within the crust and the magma sources. A detailed structural analysis of the whole massif highlights the crustal-scale anastomosed network of the EVSZ. Microstructural observations and LA-ICPMS U–Th–Pb zircon ages from large plutons constrain the beginning of the transpression at ca. 340 Ma. From 340 to 305 Ma, the EVSZ broadened and formed a 25 km-wide dextral S–C–C’ anastomosed shear zone network with dilation zones acting as preferential pathways for melt migration and pluton growths. Moreover, LA-ICPMS U–Th–Pb zircon ages from small magmatic bodies (i.e. pegmatite, aplite and microgranite) indicate an Ordovician-age inheritance component. Field evidences and zircon inheritance indicate that Late Carboniferous granitic melts are mainly derived from water-fluxed melting of Ordovician orthogneiss with the input of mantle-source derived magmas. Over time, the growth of the dextral anastomosed network enhanced water transfer through the shear zones and water-fluxed melting to produce more anatectic melts.

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Fichiers liés : Pre-proof Vanardois et al., 2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Huong Duong ThiJean-Pierre MolesPham Minh KhueR. ValloHoang Thi GiangVinh Vu HaiOanh Thi Hai KhuatThanh Tuyet Thi NhamDuc Quang NguyenCatherine QuilletDelphine RapoudPhilippe Van de PerreJoëlle CastellaniJonathan FeelemyerLaurent MichelDidier LaureillardDon C Des JarlaisNicolas Nagot
• Organismes : Dpt of Public Health [Hai Phong] Pathogenesis and Control of Chronic and Emerging Infections Dpt of Public Health [Hai Phong] Pathogenesis and Control of Chronic and Emerging Infections Dpt of Public Health [Hai Phong] Viet Tiep Hospital [Hai Phong, Vietnam] Dpt of Public Health [Hai Phong] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections College of Global Public Health [New York] Centre de recherche en épidémiologie et santé des populations Pathogenesis and Control of Chronic and Emerging Infections Hôpital Universitaire Carémeau [Nîmes] New York University [New York] Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans The Lancet Regional Health - Western Pacific le 27/10/2020

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Résumé : Background In most low-to-middle-income countries, HIV control at the population level among people who inject drugs (PWID) remains a major challenge. We aimed to demonstrate that an innovative intervention can identify HIV-positive PWID in the community who are not treated efficiently, and get them treated efficiently. Methods Between 2016 and 2020, we implemented an intervention consisting of mass HIV screening of PWID using three annual respondent-driven sampling surveys (RDSS) and a post-intervention evaluation RDSS in community-based organisation (CBO) sites, coupled with peer support to facilitate/improve access to antiretroviral and methadone therapy in Haiphong, Vietnam. The primary outcome was the proportion of identified uncontrolled HIV-positive PWID who achieved viral control. We also estimated the potential effect of the intervention on the proportion of PWID with HIV RNA >1000 copies/mL among all PWID during the study period. Findings Over the three RDSS, 3150 different PWID were screened, i.e. two-thirds of the estimated population size. They all injected heroin, their median age was of 39 years, 95% were male, 26.5% were HIV-infected, and 78.6% of the latter had HIV RNA ≤1000 copies/mL. Among the 177 PWID identified with an unsuppressed viral load, 73 (41.2%) achieved viral suppression at the final visit. HIV viremia decreased from 7.2% at baseline to 2.9% at the final RDSS (p<0.001). Up to 42% of this observed reduction may be explained by the intervention, in the absence of any external intervention targeting PWID during the study period. Interpretation Mass community-based screening using RDSS coupled with CBO support is a powerful tool to rapidly identify untreated HIV-positive PWID and (re)link them to care.

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Fichiers liés : 10.1016-J.lanwpc.2022.100538.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2022
• Auteurs : Daniel WeissZied LandoulsiPatrick MayManu SharmaMichael SchüpbachHana YouJean-Christophe CorvolSteffen PaschenAnn-Kristin HelmersMichael BarbeGereon FinkAndrea KühnChristine Brefel CourbonLars WojteckiPhilippe DamierValérie FraixJean-Luc HouetoJean RegisFriederike Sixel-DöringMarcus PinskerStéphane ThoboisAlireza GharabaghiValerie StokerLars TimmermannAlfons SchnitzlerPaul KrackMarie VidailhetGünther DeuschlRejko Krüger
• Organismes : Hertie Institute for Clinical Brain Research [Tubingen] Luxembourg Centre For Systems Biomedicine Luxembourg Centre For Systems Biomedicine Eberhard Karls Universität Tübingen = University of Tübingen Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Bern University Hospital [Berne] Universität Bern = University of Bern = Université de Berne Bern University Hospital [Berne] Universität Bern = University of Bern = Université de Berne Institut du Cerveau = Paris Brain Institute AP-HP - Hôpital de la Pitié Salpêtrière Institut du Cerveau = Paris Brain Institute University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein University Hospital of Cologne [Cologne] Jülich Research Centre Charité - UniversitätsMedizin = Berlin University Medicine Toulouse NeuroImaging Center Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Centre d’Investigation Clinique de Nantes [GIN] Grenoble Institut des Neurosciences Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale Service de neurochirurgie [CHU Marseille] Paracelsus-Elena-Klinik, Kassel, Germany. Universitäts Klinikum Freiburg = University Medical Center Freiburg Service d'Electroneuromyographie et Service de Neurologie C [Hôpital Pierre Wertheimer - HCL] Université Claude Bernard Lyon 1 Universitätsklinikum Tübingen = University Hospital of Tuebingen Medtronic Inc [Minneapolis, MI, USA] Philipps Universität Marburg = Philipps University of Marburg Toulouse NeuroImaging Center Bern University Hospital [Berne] Universität Bern = University of Bern = Université de Berne Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Bern University Hospital [Berne] Universität Bern = University of Bern = Université de Berne Institut du Cerveau = Paris Brain Institute Luxembourg Centre For Systems Biomedicine Luxembourg Institute of Health Centre Hospitalier de Luxembourg [Luxembourg]
• Publié dans Parkinsonism & Related Disorders le 02/11/2020

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Résumé : Purpose: The decision for subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD) relies on clinical predictors. Whether genetic variables could predict favourable or unfavourable decisions is under investigation. Objective: First, we aimed to reproduce the previous observation that SNCA rs356220 was associated with favourable STN-DBS motor response. In additional exploratory analyses, we studied if other PD risk and progression variants from the latest GWAS are associated with therapeutic outcome. Further, we evaluated the predictive value of polygenic risk scores. Methods: We comprehensively genotyped patients from the EarlyStim cohort using NeuroChip, and assessed the clinico-genetic associations with longitudinal outcome parameters. Results: The SNCA rs356220 variant did not predict UPDRS III outcomes. However, it was associated with quality of life improvement in secondary analyses. Several polymorphisms from previously identified GWAS hits predicted motor or quality of life outcomes in DBS patients. Polygenic risk scores did not predict any outcome parameter. Conclusions: Our findings support the hypothesis that different common genetic markers are associated with favourable quality of life outcomes of STN-DBS in PD. These findings can be the basis for further validation in larger and independent cohorts.

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