Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Marine GaudryAlizée PortoArnaud BlanchardJean-Victor ChazotLaurence BalMariangela de MasiAxel BartoliPierre-Antoine BarralAlexis JacquierVlad GariboldiFréderic CollartValerie DeplanoPhilippe Piquet
• Organismes : Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Institut de Recherche sur les Phénomènes Hors Equilibre Hôpital de la Timone [CHU - APHM]
• Publié dans Cardiovascular Drugs and Therapy le 29/10/2020

---

Résumé : Purpose Hybrid aortic arch repair in patients with chronic residual aortic dissection (RAD) is a less invasive alternative to conventional surgical treatment. The aim of this study was to describe the short-term and long-term results of hybrid treatment for RAD after type A repair. Methods In this retrospective single-center cohort study, all patients treated for chronic RAD with hybrid aortic arch repair were included. Indications for treatment were rapid aortic growth, aortic diameter > 55 mm, or aortic rupture. Results Between 2009 and 2020, we performed 29 hybrid treatments for chronic RAD. Twenty-four patients were treated for complete supra-aortic debranching in zones 0 and 5 with left subclavian artery debranching alone in zone 2. There was 1 perioperative death (3.4%): The patient was treated for an aortic rupture. There was no spinal cord ischemia and 1 minor stroke (3.4%). After a median follow-up of 25.4 months (range 3-97 months), the long-term mortality was 10.3% (3/29) with no late aortic-related deaths. Twenty-seven patients (93.1%) developed FL thrombosis of the descending thoracic aorta; the rate of aneurysmal progression on thoraco-abdominal aorta was 41.4% (12/29), and the rate of aortic reintervention was 34.5% (10/29). Conclusion In a high-volume aortic center, hybrid repair of RAD is associated with good anatomical results and a low risk of perioperative morbidity and mortality, including that of patients treated in zone 0. A redo replacement of the ascending aortic segment is sometimes necessary to provide a safer proximal landing zone and reduce the risk of type 1 endoleak after TEVAR.

---

Fichiers liés : Gaudry2021_Article_A10-YearAorticCenterExperience.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Mustapha MeftahFabrice BoustPhilippe KeckhutAlain SarkissianThomas BoutéraonSlimane BekkiLuc DaméPatrick H. M. GalopeauAlain HauchecorneChristophe DufourAdrien FinanceAndré-Jean VieauEmmanuel BertranPierre GilbertNicolas CaignardClément DiasJean-Luc EnglerPatrick LacroixKévin GrosselVéronique RannouStéphane SaillantYannick AvelinoBenjamin AzoulayCyril BrandCarlos DominguezAkos HaaszAgne PaskeviciuteKevin SeguraPierre MasoSébastien AncelinChristophe MercierValentin StéeAntoine ManginDavid BolséeCatherine Billard
• Organismes : STRATO - LATMOS DEMR, ONERA, Université Paris Saclay [Palaiseau] STRATO - LATMOS STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS HELIOS - LATMOS HELIOS - LATMOS STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS Analytic and Computational Research, Inc. - Earth Sciences Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Observatoire de Versailles Saint-Quentin-en-Yvelines Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales DEMR, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] Innovative Solutions In Space [Delft] Innovative Solutions In Space [Delft] Innovative Solutions In Space [Delft] Observatoire de Versailles Saint-Quentin-en-Yvelines Observatoire de Versailles Saint-Quentin-en-Yvelines Analytic and Computational Research, Inc. - Earth Sciences Analytic and Computational Research, Inc. - Earth Sciences Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique Centre de recherche en épidémiologie et santé des populations
• Publié dans Remote Sensing le 28/10/2020

---

Résumé : INSPIRE-SAT 7 is a French 2-Unit CubeSat (11.5 × 11.5 × 22.7 cm) primarily designed for Earth and Sun observation. INSPIRE-SAT 7 is one of the missions of the International Satellite Program in Research and Education (INSPIRE). Twice the size of a 4 × 4 Rubik’s Cube and weighing about 3 kg, INSPIRE-SAT 7 will be deployed in Low Earth Orbit (LEO) in 2023 to join its sister satellite, UVSQ-SAT. INSPIRE-SAT 7 represents one of the in-orbit demonstrators needed to test how two Earth observation CubeSats in orbit can be utilized to set up a satellite constellation. This new scientific and technological pathfinder CubeSat mission (INSPIRE-SAT 7) uses a multitude of miniaturized sensors on all sides of the CubeSat to measure the Earth’s energy budget components at the top-of-the-atmosphere for climate change studies. INSPIRE-SAT 7 contains also a High-Frequency (HF) payload that will receive HF signals from a ground-based HF transmitter to probe the ionosphere for space weather studies. Finally, this CubeSat is equipped with several technological demonstrators (total solar irradiance sensors, UV sensors to measure solar spectral irradiance, a new Light Fidelity (Li-Fi) wireless communication system, a new versatile telecommunication system suitable for CubeSat). After introducing the objectives of the INSPIRE-SAT 7 mission, we present the satellite definition and the mission concept of operations. We also briefly show the observations made by the UVSQ-SAT CubeSat, and assess how two CubeSats in orbit could improve the information content of their Earth’s energy budget measurements. We conclude by reporting on the potential of future missions enabled by CubeSat constellations.

---

Fichiers liés : remotesensing-14-00186-v2.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Philippe GoupillePhilippe BertinFlorence TubachEric LespessaillesNaoual HaridSaannya SequeiraJean-Marie FayetteBruno FautrelRené-Marc Flipo
• Organismes : Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-.2022] Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital Roger Salengro [Lille] Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Clinical and Experimental Rheumatology le 12/11/2022

---

Résumé : OBJECTIVES: To evaluate in clinical practice the persistence and safety of golimumab, together with the evolution of disease activity and patient reported outcomes, in adult patients with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis (axSpA). This article focuses on the outcomes of golimumab treatment in axSpA patients. METHODS: Golimumab persistence 24 months after initial prescription (primary outcome) was assessed using Kaplan-Meier estimates. Secondary outcomes included evaluations of disease activity evolution (ASDAS and BASDAI), patient-reported outcomes (EQ-5D, SF-12 and HAQ), and golimumab's safety profile. RESULTS: Of 478 axSpA patients, 60.9% were biologic-na\"ive. Mean age and proportion of females were higher in biologics-pretreated patients (46.8 vs. 40.2 years, p<0.001 and 62.0% vs. 49.8%, p=0.009, respectively). Golimumab persistence at 24 months was 52.6% [95% CI 47.9-57.1%] in the axSpA cohort. It was 59.2% [95% CI 53.1-64.8%] and 42.7% [95% CI 35.3-49.8%] respectively, for biologics-na\"ive and biologics-pretreated patients (p<0.01), and 65.9% [95% CI 58.9-72.0%] and 41.5% [95% CI 35.2-47.6%], respectively for males and females (p<0.01). Reasons for golimumab discontinuation were primary non-response (37.4%), secondary non-response (24.8%) and intolerance (21.5%). Disease activity and patient reported outcomes improved significantly for those who persisted at 24 months and were higher for biologics-na\"ive patients. CONCLUSIONS: Golimumab persistence at 2 years in axSpA patients was 52.6%. Previous treatment with another biologic and female gender were associated with earlier discontinuation. Golimumab was a well-tolerated therapy for axSpA, with no new safety signals observed.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Jean-Philippe BanonPierre PelletierClaude WeisbuchSvitlana MayborodaMarcel Filoche
• Organismes : Laboratoire de physique de la matière condensée Laboratoire de physique de la matière condensée Laboratoire de physique de la matière condensée University of California [Santa Barbara] University of Minnesota [Twin Cities] Laboratoire de physique de la matière condensée
• Publié dans Physical Review B le 27/10/2020

---

Résumé : The presence of disorder in semiconductors can dramatically change their physical properties. Yet, models faithfully accounting for it are still scarce and computationally inefficient. We present a mathematical and computational model able to simulate the optoelectronic response of semiconductor alloys of several tens of nanometer sidelength, while at the same time accounting for the quantum localization effects induced by the compositional disorder at the nanoscale. The model is based on a Wigner-Weyl analysis of the structure of electron and hole eigenstates in phase space made possible by the localization landscape theory. After validation against eigenstate-based computations in 1D and 2D, our model is applied to the computation of light absorption in 3D InGaN alloys of different compositions. We obtain the detailed structures of the absorption tail below the average band gap and the Urbach energies of all simulated compositions. Moreover, the Wigner-Weyl formalism allows us to define and compute 3D maps of the effective locally absorbed power at all frequencies. Finally, the proposed approach opens the way to generalize this method to all energy-exchange processes such as radiative and nonradiative recombination in realistic devices.

---

Fichiers liés : 2112.06485

---

Source

---

• Type de publi. : Rapport
• Date de publi. : 01/01/2022
• Auteurs : Philippe GardesKevin BouchitéWilfried LabartheAdrien MaguyMarion NouvelPierre PéfauMatthieu Soler
• Organismes : Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Archéologie des Sociétés Méditerranéennes Université Bordeaux Montaigne Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge Pôle de recherche archéologique [Nantes Métropole] Centre d'études et de recherches archéologiques en Gascogne Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Université Toulouse - Jean Jaurès Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Bruna MeiraEugénie LhomméeEmmanuelle SchmittHélène KlingerAmélie BichonPierre PélissierMathieu AnheimChristine TranchantValérie FraixSara MeoniFranck DurifJean-Luc HouetoJean Philippe AzulayElena MoroStéphane ThoboisPaul KrackAnna Castrioto
• Organismes : Institut de Génétique et de Biologie Moléculaire et Cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de Génétique et de Biologie Moléculaire et Cellulaire
• Publié dans Journal of Parkinson's disease le 29/10/2020

---

Résumé : BACKGROUND: Previous studies described a parkinsonian personality characterized as rigid, introverted, and cautious; however, little is known about personality traits in de novo Parkinson's disease (PD) patients and their relationships with motor and neuropsychiatric symptoms. OBJECTIVE: To investigate personality in de novo PD and explore its relationship with PD symptoms. METHODS: Using Cloninger's biosocial model, we assessed personality in 193 de novo PD patients. Motor and non-motor symptoms were measured using several validated scales. Cluster analysis was conducted to investigate the interrelationship of personality traits, motor, and non-motor symptoms. RESULTS: PD patients showed low novelty seeking, high harm avoidance, and normal reward dependence and persistence scores. Harm avoidance was positively correlated with the severity of depression, anxiety, and apathy (rs = [0.435, 0.676], p < 0.001) and negatively correlated with quality of life (rs = -0.492, p < 0.001). Novelty seeking, reward dependence, and persistence were negatively correlated with apathy (rs = [-0.274, -0.375], p < 0.001). Classification of patients according to personality and PD symptoms revealed 3 distinct clusters: i) neuropsychiatric phenotype (with high harm avoidance and low novelty seeking, hypodopaminergic neuropsychiatric symptoms and higher impulsivity), ii) motor phenotype (with low novelty seeking and higher motor severity), iii) benign phenotype (with low harm avoidance and high novelty seeking, reward dependence, and persistence traits clustered with lower symptoms severity and low impulsivity). CONCLUSION: Personality in early PD patients allows us to recognize 3 patients' phenotypes. Identification of such subgroups may help to better understand their natural history. Their longitudinal follow-up will allow confirming whether some personality features might influence disease evolution and treatment.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Matthieu BéreauAnna CastriotoEugénie LhomméeAudrey MailletAurélie GérazimeAmélie BichonPierre PélissierEmmanuelle SchmittHélène KlingerNadine LongatoValérie FraixIsabelle BenatruFranck DurifJean-Philippe AzulayElena MoroEmmanuel BroussolleChristine TranchantMathieu AnheimStéphane ThoboisPaul Krack
• Organismes : Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie Institut de génétique et biologie moléculaire et cellulaire Institut de Génétique et de Biologie Moléculaire et Cellulaire Institut de Génétique et de Biologie Moléculaire et Cellulaire Institut de génétique et biologie moléculaire et cellulaire
• Publié dans Journal of Parkinson's disease le 29/10/2020

---

Résumé : BACKGROUND: Fatigue is a frequent and troublesome symptom present from the early stages of Parkinson's disease (PD). OBJECTIVE: To examine the relationship between fatigue and the neuropsychiatric triad, which includes apathy, depression, and anxiety, in de novo PD. METHODS: We performed a cross-sectional study including 197 patients with de novo PD and assessed fatigue using the Parkinson's Disease Fatigue Scale (PDFS-16). We evaluated motor status using the Unified Parkinson's Disease Rating Scale (UPDRS) part III score and evaluated neuropsychiatric status using the Ardouin Scale of Behavior in Parkinson's Disease (ASBPD). We carried out univariate and multivariate analyses to model association between motor signs, non-motor signs, and fatigue risk. RESULTS: Frequency of fatigue (28.9%) was of the same order of magnitude as that of apathy. PD patients with fatigue reported a lower quality of life than patients without fatigue (p < 0.0001). The ASBPD showed that patients with fatigue had higher scores for depressed mood (p < 0.0001), anxiety (p < 0.0001), and apathy (p < 0.0001). In the univariate analysis, fatigue score was positively correlated with apathy, depression, anxiety, and the neuropsychiatric triad as a whole, and to a lesser extent with female sex, hyperemotivity, and the UPDRS part III score. In the multivariate analysis, after adjusting for sex and motor status, the fatigue score remained significantly correlated with apathy (OR = 11.17 [4.33-28.78], p < 0.0001) and depression (OR = 4.28 [1.39-13.12], p = 0.01), but not with anxiety (OR = 0.94 [0.34-2.58], p = 0.9). CONCLUSION: We propose that the neuropsychiatric triad could be expanded to include fatigue.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Simon PageaudAnne Eyraud-LoiselJean-Pierre BertoglioAlexis BienvenüeNicolas LeboisneCatherine PothierChristophe RigottiNicolas PonthusRomain GauchonFrançois GueyffierPhilippe VanhemsJean IwazStéphane LoiselPascal Roy
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Laboratoire de Sciences Actuarielle et Financière Laboratoire de Sciences Actuarielle et Financière Université Claude Bernard Lyon 1 Laboratoire de Mecanique des Fluides et d'Acoustique Laboratoire de Sciences Actuarielle et Financière Laboratoire de Sciences Actuarielle et Financière Extraction de Caractéristiques et Identification Data Mining and Machine Learning Artificial Evolution and Computational Biology Laboratoire d'InfoRmatique en Image et Systèmes d'information École Centrale de Lyon Laboratoire de Tribologie et Dynamique des Systèmes Laboratoire de Sciences Actuarielle et Financière Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Hospices Civils de Lyon Centre International de Recherche en Infectiologie F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Laboratoire de Sciences Actuarielle et Financière Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon]
• Publié dans Vaccines le 28/10/2020

---

Résumé : The major economic and health consequences of COVID-19 called for various protective measures and mass vaccination campaigns. A previsional model was used to predict the future impacts of various measure combinations on COVID-19 mortality over a 400-day period in France. Calibrated on previous national hospitalization and mortality data, an agent-based epidemiological model was used to predict individual and combined effects of booster doses, vaccination of refractory adults, and vaccination of children, according to infection severity, immunity waning, and graded non-pharmaceutical interventions (NPIs). Assuming a 1.5 hospitalization hazard ratio and rapid immunity waning, booster doses would reduce COVID-19-related deaths by 50–70% with intensive NPIs and 93% with moderate NPIs. Vaccination of initially-refractory adults or children ≥5 years would half the number of deaths whatever the infection severity or degree of immunity waning. Assuming a 1.5 hospitalization hazard ratio, rapid immunity waning, moderate NPIs and booster doses, vaccinating children ≥12 years, ≥5 years, and ≥6 months would result in 6212, 3084, and 3018 deaths, respectively (vs. 87,552, 64,002, and 48,954 deaths without booster, respectively). In the same conditions, deaths would be 2696 if all adults and children ≥12 years were vaccinated and 2606 if all adults and children ≥6 months were vaccinated (vs. 11,404 and 3624 without booster, respectively). The model dealt successfully with single measures or complex combinations. It can help choosing them according to future epidemic features, vaccination extensions, and population immune status.

---

Fichiers liés : PAGEAUD_EYRAUD-LOISEL_BERTOGLIO_et_al_2022.pdf

---

Source

---

• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2022
• Auteurs : Martine AntonaSigrid Aubert GilonAurélie BottaFrançois BousquetWilliam’s DaréEtienne DelayNicolas Gaidet-DrapierFrançoise GérardPhilippe KarpeChristophe Le PageJean-Pierre Müller
• Organismes : Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés Savoirs, ENvironnement et Sociétés

---

Fichiers liés : ID601169.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Yunsong LiuJean-Daniel ParisMihalis VrekoussisPanayiota AntoniouChristos ConstantinidesMaximilien DesservettazChristos KeleshisOlivier LaurentAndreas LeonidouCarole PhilipponPanagiotis VouterakosPierre Yves QuéhéPhilippe BousquetJean Sciare
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation INVerse pour les mesures atmosphériques et SATellitaires
• Publié dans Atmospheric Measurement Techniques le 24/10/2020

---

Résumé : Unmanned aerial vehicles (UAVs) provide a cost-effective way to fill in gaps between surface in situ observations and remotely sensed data from space. In this study, a novel portable CO2 measuring system suitable for operations on board small-sized UAVs has been developed and validated. It is based on a low-cost commercial nondispersive near-infrared (NDIR) CO2 sensor (Senseair AB, Sweden), with a total weight of 1058 g, including batteries. The system performs in situ measurements autonomously, allowing for its integration into various platforms. Accuracy and linearity tests in the lab showed that the precision remains within ± 1 ppm (1σ) at 1 Hz. Corrections due to temperature and pressure changes were applied following environmental chamber experiments. The accuracy of the system in the field was validated against a reference instrument (Picarro, USA) on board a piloted aircraft and it was found to be ± 2 ppm (1σ) at 1 Hz and ± 1 ppm (1σ) at 1 min. Due to its fast response, the system has the capacity to measure CO2 mole fraction changes at 1 Hz, thus allowing the monitoring of CO2 emission plumes and of the characteristics of their spatial and temporal distribution. Details of the measurement system and field implementations are described to support future UAV platform applications for atmospheric trace gas measurements. Copyright

---

Fichiers liés : amt-15-4431-2022.pdf

---

Source