Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Pierre BayMarc de ChambrunVincent RothsteinMatthiéu MahevasNicolas de ProstAntoine RouxBenjamin ZuberDominique Israël BietBaptiste HervierAbdellatif TaziLuc MouthonArsène MékinianChristophe N. DelignyRaphaël BorieJean-Claude MeuriceAlain MeyerPascaline PriouLaurent SavaleLuc de Saint MartinLaure GallayVincent CottinElodie BlanchardPierre Yves BrilletPhilippe KhafagyOlivier BenvenisteHilario NunesYurdagül UzunhanYves Allenbach
• Organismes : Service de pneumologie [Avicenne] CHU Pitié-Salpêtrière [AP-HP] Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Service de pneumologie [Avicenne] Hôpital Européen Georges Pompidou [APHP] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine Groupe Henri Mondor-Albert Chenevier Université de Versailles Saint-Quentin-en-Yvelines Service de pneumologie [Hôpital Foch] Hôpital Foch [Suresnes] Université Paris Cité Hopital Saint-Louis [AP-HP] Immunologie humaine, physiopathologie & immunothérapie Hopital Saint-Louis [AP-HP] Hôpital Cochin [AP-HP] CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire d'Angers Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hôpital Morvan [Brest] Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Hospices Civils de Lyon Hôpital Haut-Lévêque [CHU Bordeaux] Service de radiologie [Avicenne] Service de radiologie [Avicenne] Centre de recherche en Myologie – U974 SU-INSERM CHU Pitié-Salpêtrière [AP-HP] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Service de pneumologie [Avicenne] Service de pneumologie [Avicenne] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Centre de recherche en Myologie – U974 SU-INSERM CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Journal of Autoimmunity le 01/11/2020

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Résumé : Background: Rapidly progressive interstitial lung disease (RP-ILD) is a frequent and severe manifestation of anti-MDA5 dermatomyositis (MDA5-DM) associated with poor outcome. The optimal treatment regimen for MDA5-DM RP-ILD is yet to be determined. Specifically, the value of adding plasma exchange (PLEX) to corticosteroids and immunosuppressants remains unclear. We aimed to evaluate the effect of PLEX on the outcome of patients with MDA5-DM RP-ILD. Methods: This French nationwide multicentre retrospective study included all MDA5-DM RP-ILD patients from 2012 to 2021 admitted to 18 centres. The primary endpoint was one-year transplant-free survival. Results: 51 patients with MDA5-DM RP-ILD (female 67%; mean age at disease onset: 51 ± 11.6 years) were included. Thirty-two (63%) patients required mechanical ventilation and twenty-five (49%) received PLEX. One-year mortality or lung transplant occurred in 63% cases after a median follow-up of 77 [38–264] days. The Cox proportional hazards multivariable model only retained mechanical ventilation but not PLEX (p = 0.7) as independent predictor of the primary endpoint. One-year transplant-free survival rates in PLEX + vs. PLEX-were 20% vs. 54% (p = 0.01), respectively. The Kaplan–Meier estimated probabilities of one-year transplant-free survival was statistically higher in PLEX-compared to PLEX + patients (p = 0.05). PLEX + compared to PLEX-patients more frequently received mechanical ventilation and immunosuppressants suggesting PLEX + patients had a more severe disease. Conclusion: MDA5-DM RP-ILD is associated with poor rate of one-year transplant-free survival. The use of PLEX was not associated with a better outcome albeit they were mainly given to more severe patients. While our study reports the largest series of MDA5-DM RP-ILD given PLEX, these results needs to be interpreted with caution owing the numerous selection, indication and interpretation bias. Further studies are needed to evaluate their efficacy in this setting.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Fabrice DemeterClément ZanolliKira E WestawayRenaud Joannes-BoyauPhilippe DuringerMike W MorleyFrido WelkerPatrick Leopold RütherMatthew SkinnerHugh MccollCharleen GaunitzLasse VinnerTyler E. DunnJesper Velgaard OlsenMartin SikoraJean-Luc PoncheEric SuzzoniSébastien FrangeulQuentin BoeschPierre-Olivier AntoineLei PanSong XingJian-Xin ZhaoRichard M BaileySouliphane BoualaphanePhonephanh SichanthongtipDaovee SihanamElise Patole-EdoumbaFrançoise Aubaile-SallenaveFrançoise CrozierNicolas BourgonAlexandra J ZachwiejaThonglith LuangkhothViengkeo SouksavatdyThongsa SayavongkhamdyEnrico CappelliniAnne-Marie BaconJean-Jacques HublinEske WillerslevLaura Shackelford
• Organismes : Globe Institute Éco-Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Macquarie University [Sydney] Southern Cross University University of Johannesburg [Johannesbourg, South Africa] Institut de physique du globe de Strasbourg Flinders University [Adelaide, Australia] Globe Institute Novo Nordisk Foundation Center for Protein Research School of Anthropology and Conservation [University of Kent] Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Globe Institute Globe Institute Globe Institute Creighton University School of Medicine Novo Nordisk Foundation Center for Protein Research Globe Institute Laboratoire Image, Ville, Environnement Auteur indépendant Auteur indépendant Institut de physique du globe de Strasbourg Institut des Sciences de l'Evolution de Montpellier Key Laboratory of Vertebrate Evolution and Human Origins State Key Laboratory of Palaeobiology and Stratigraphy Key Laboratory of Vertebrate Evolution and Human Origins CAS Center for Excellence in Life and Paleoenvironment The University of Queensland School of Geography and the Environment [Oxford] Auteur indépendant Auteur indépendant Auteur indépendant Museum d'Histoire Naturelle de La Rochelle Éco-Anthropologie Diversité, adaptation, développement des plantes Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology University of Minnesota [Duluth] Auteur indépendant Auteur indépendant Auteur indépendant Globe Institute Biologie, anthropologie, biométrie, épigénétique, lignées : De la diversité des populations à l'individu, de l'identification à l'identité Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Collège de France - Chaire Paléoanthropologie Globe Institute University of Cambridge [Cambridge, UK] The Wellcome Trust Sanger Institute [Cambridge] University of Southern Denmark University of Illinois at Urbana-Champaign [Urbana]
• Publié dans Nature Communications le 23/10/2020

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Résumé : The Pleistocene presence of the genus Homo in continental Southeast Asia is primarily evidenced by a sparse stone tool record and rare human remains. Here we report a Middle Pleistocene hominin specimen from Laos, with the discovery of a molar from the Tam Ngu Hao 2 (Cobra Cave) limestone cave in the Annamite Mountains. The age of the fossil-bearing breccia ranges between 164-131 kyr, based on the Bayesian modelling of luminescence dating of the sedimentary matrix from which it was recovered, U-series dating of an overlying flowstone, and U-series-ESR dating of associated faunal teeth. Analyses of the internal structure of the molar in tandem with palaeoproteomic analyses of the enamel indicate that the tooth derives from a young, likely female, Homo individual. The close morphological affinities with the Xiahe specimen from China indicate that they belong to the same taxon and that Tam Ngu Hao 2 most likely represents a Denisovan.

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Fichiers liés : s41467-022-29923-z.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Joël BarraultPhilippe ColombanJean-Pierre Foulon
• Organismes : Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies ESCOM - Ecole Supérieure de Chimie Organique et Minérale
• Publié dans L'Actualité Chimique le 02/11/2020

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Fichiers liés : AC- Vins 2022 dec 479.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Nathalie CostetAntoine LafontaineFlorence RougetLéah MichineauChristine MonfortJean-Pierre ThomePhilippe KadhelLuc MultignerSylvaine Cordier
• Organismes : Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail CHU Pointe-à-Pitre / Abymes [Guadeloupe] École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Centre d’Ingénierie des Protéines [Université de Liège] = Centre for Protein Engineering [University of Liège] Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique
• Publié dans Environmental Health le 28/10/2020

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Résumé : Background Exposure to persistent environmental organic pollutants may contribute to the development of obesity among children. Chlordecone is a persistent organochlorine insecticide with estrogenic properties that was used in the French West Indies (1973-1993) and is still present in the soil and the water and food consumed by the local population. We studied the association between prenatal and childhood exposure to chlordecone and the adiposity of prepubertal children. Methods Within the Timoun Mother-Child Cohort Study in Guadeloupe (French West Indies), 575 children had a medical examination at seven years of age, including adiposity measurements. A Structural Equation Modeling approach was used to create a global adiposity score from four adiposity indicators: the BMI z-score, percentage of fat mass, sum of the tricipital and subscapular skinfold thickness, and waist-to-height ratio. Chlordecone concentrations were measured in cord blood at birth and in the children's blood at seven years of age. Models were adjusted for prenatal and postnatal covariates. Sensitivity analyses accounted for co-exposure to PCB-153 and pp'-DDE. Mediation analyses, including intermediate birth outcomes, were conducted. Results Prenatal chlordecone exposure tended to be associated with increased adiposity at seven years of age, particularly in boys. However, statistical significance was only reached in the third quartile of exposure and neither linear nor non-linear trends could be formally identified. Consideration of preterm birth or birth weight in mediation analyses did not modify the results, as adjustment for PCB-153 and pp'-DDE co-exposures. Conclusion Globally, we found little evidence of an association between chlordecone exposure during the critical in utero or childhood periods of development and altered body-weight homeostasis in childhood. Nevertheless, some associations we observed at seven years of age, although non-significant, were consistent with those observed at earlier ages and would be worth investing during further follow-ups of children of the Timoun Mother-Child Cohort Study when they reach puberty.

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Fichiers liés : s12940-022-00850-2

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Marie Hauguel-MoreauVincent AïdanHélène HergaultAlain BeauchetMarion PépinGiulio PratiRémy PillièreMounir OuadahiLoïc JosseranChristophe RodonJean-Pierre RabèsPhilippe CharronOlivier DubourgZiad MassyNicolas Mansencal
• Organismes : Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Caisse primaire d'assurance maladie Hôpital Ambroise Paré [AP-HP] Université Paris-Saclay Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Hôpital Ambroise Paré [AP-HP] Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : Background: Familial hypercholesterolaemia (FH) is responsible for severe hypercholesterolaemia and premature cardiovascular morbidity and mortality. The first clinical event is typically an acute coronary syndrome. Unfortunately, FH is largely underdiagnosed in the general population. Aims: To assess the prevalence of clinical FH among patients with premature (aged ≤ 50 years) acute myocardial infarction (MI) and compare it with FH prevalence in a control population. Methods: We reviewed in our database all patients with premature MI (aged ≤ 50 years) referred to Ambroise Paré Hospital from 2014 to 2018. FH prevalence was estimated via the Dutch Lipid Clinic Network score, based on personal and family history of premature cardiovascular disease and low-density lipoprotein cholesterol concentrations. FH was “possible” with a score between 3 and 5 points, “probable” with a score between 6 and 8 and “definite” with a score above 8. FH prevalence in young patients with MI was then compared with FH prevalence in a general population of the same age from the CARVAR 92 prospective cohort. Results: Of the 457 patients with premature MI, 29 (6%) had “probable” or “definite” FH. In the CARVAR 92 cohort, 16 (0.16%) of 9900 subjects aged ≤ 50 years had “probable” or “definite” FH. FH prevalence was 39 times greater among patients with premature MI than in the control population (P < 0.0001). In multivariable analysis, FH was strongly associated with MI (adjusted odds ratio 38.4, 95% confidence interval 19.1–79.4). Conclusions: FH is > 30-fold more common in patients referred for premature MI than in the general population; this highlights the need for FH screening after a first MI to enhance lipid-lowering therapy and allow early identification of family members.

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Fichiers liés : S1875213622000146.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Oumarou NabiJérôme BoursierNathanaël LapidusPhilippe MathurinVictor de LedinghenJean-Michel PetitMarcel GoldbergMarie ZinsKarine LacombeLawrence D. Serfaty
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] UFR Sciences de la santé Simone Veil Université Paris Cité Centre Hospitalier Universitaire d'Angers Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Institut Pierre Louis d'Epidémiologie et de Santé Publique Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Universitaire de Bordeaux Service d'Endocrinologie, Diabétologie et Maladies Métaboliques (CHU de Dijon) UFR Sciences de la santé Simone Veil Université Paris Cité Cohortes épidémiologiques en population UFR Sciences de la santé Simone Veil Université Paris Cité Cohortes épidémiologiques en population Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Hôpital de Hautepierre [Strasbourg] Centre de Recherche Saint-Antoine
• Publié dans Liver International le 25/10/2020

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Résumé : Background: The epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD) in diabetes have been mainly investigated in the hospital setting. The goal of this study was to evaluate the characteristics of NAFLD and its impact on morbidity and mortality in type 2 diabetic subjects in a community setting. Method: This study included 199 341 participants in the nationwide Constances cohort. After patients with excessive alcohol consumption, viral hepatitis or other causes of liver disease were excluded, 164 285 were analysed and 8386 (5.3%) were considered to have type 2 diabetes. The non-invasive diagnosis of NAFLD and advanced fibrosis was made using a combination of the fatty liver index and Forns index. Median follow-up was 2.5 years. Results: Diabetes increased the risk of NAFLD by sixfold (adjusted OR 6.05, 95% CI 5.68-6.45) and the risk of advanced fibrosis by 3.76-fold (aOR 3.76, 95% CI 2.87-4.91) in NAFLD subjects. After controlling for confounders, the presence of NAFLD in diabetic subjects was associated with an increased risk of severe liver-related events (aHR 2.53, 95% CI 1.36-4.69), cardiovascular disease (CVD, aHR 2.71, 95% CI 1.72-4.26) and overall mortality (aHR 2.91, 95% CI 1.53-5.53). The risk of hepatic and extrahepatic complications in diabetic subjects with NAFLD significantly increased with the severity of fibrosis (P <.05). Conclusion: This prospective, longitudinal study in a large community-based cohort provides real-world evidence of the risk for NAFLD and advanced fibrosis in diabetes, and its impact on liver disease progression, diabetes-related complications such as CVD, and overall mortality. These data could be used to estimate real clinical and economic burden of NAFLD in diabetic subjects.

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Fichiers liés : hal-03604061.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Eva Peñas-LledóSebastien GuillaumeFernando de AndrésAna Cortés-MartínezJonathan DuboisJean Pierre KahnMarion LeboyerÉmilie OliéAdrián LlerenaPhilippe Courtet
• Organismes : Universidad de Extremadura - University of Extremadura Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier] Universidad de Extremadura - University of Extremadura Universidad de Extremadura - University of Extremadura Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier] Université de Lorraine Fondation Santé des Etudiants de France Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] Institut de Génomique Fonctionnelle Hôpital Lapeyronie [CHU Montpellier] Universidad de Extremadura - University of Extremadura Centro de Investigación Biomédica en Red Salud Mental [Madrid] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle
• Publié dans Translational Psychiatry le 30/10/2020

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Résumé : This study of a cohort of 1-year treatment-compliant survivors of a suicide attempt examined for the first time whether a high CYP2D6-CYP2C19 metabolic capacity (pharmacogenes related to psychopathology, suicide, and attempt severity) and/or polypharmacy treatments predicted repeat suicide attempts, adjusting for sociodemographic and clinical factors as confounders. Of the 461 (63% women) consecutively hospitalized patients who attempted suicide and were evaluated and treated after an index attempt, 191 (67.5% women) attended their 6- and 12-month follow-up sessions. Clinicians were blinded to the activity scores (AS) of their genotypes, which were calculated as the sum of the values assigned to each allele (CYP2C19 *2, *17; CYP2D6 *3, *4, *4xN, *5, *6, *10, wtxN). No differences were found in polypharmacy prescription patterns and the variability of CYP2D6 and CYP2C19 genotypes between adherents and dropouts, but the formers were older, with a higher frequency of anxiety and bipolar disorders and fewer alcohol and substance use disorders. The risk of reattempts was higher for CYP2D6 ultrarapid (AS > 2) metabolizers (β = 0.561, p = 0.005) and violent suicide survivors (β = -0.219, p = 0.042) if the attempt occurred during the first 6-month period, individuals with an increased number of MINI DSM-IV Axis I mental disorders (β = 0.092, p = 0.032) during the second 6-month period and individuals with a combined high CYP2D6-CYP2C19 metabolic capacity (AS > 4) (β = 0.345, p = 0.024) and an increased use of drugs other than antidepressants, anxiolytics-depressants and antipsychotics-lithium (β = 0.088, p = 0.005) in multiple repeaters during both periods. CYP2D6 and CYP2C19 rapid metabolism and polypharmacy treatment for somatic comorbidities must be considered to prevent the severe side effects of short-term multiple suicide reattempts after a previous attempt.

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Fichiers liés : 41398_2022_Article_2140.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Paul GougisBaptiste AbbarJulie BenzimraAurore VozyJean-Philippe SpanoLuca Campedel
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Universitaire de Cancérologie [Sorbonne Université] Immunité et cancer Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Universitaire de Cancérologie [Sorbonne Université] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Universitaire de Cancérologie [Sorbonne Université] Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Universitaire de Cancérologie [Sorbonne Université] CHU Gabriel Montpied [Clermont-Ferrand]
• Publié dans Diagnostics le 01/11/2020

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Résumé : Immunotherapies and immune checkpoint inhibitors (ICI) represent the latest revolution in oncology. Several studies have reported an association between the use of corticosteroids and poorer outcomes for patients treated with ICIs. However, it has been never established whether corticoid-induced tumor progression under ICI treatment could be reversible. We report herein transient tumor progression induced by dexamethasone for a patient treated with pembrolizumab for metastatic bladder cancer. An 82-year-old man was treated with pembrolizumab as a second-line treatment for metastatic urothelial carcinoma with stable disease for 8 months as the best tumoral response. He experienced severe coronavirus disease 2019 (COVID-19) infection and was treated with high-dose dexamethasone for ten days according to the RECOVERY protocol. Following this episode, radiological CT-scan evaluation showed tumor progression. Pembrolizumab was maintained, and subsequent radiological evaluation showed tumor shrinkage. This case highlights that the antagonistic effect of glucocorticoids with ICI efficacy is transient and can be reverted when corticoids are withdrawn. Clinicians should be aware that tumor progression in the context of the intercurrent use of systemic corticosteroids can be temporary and should be interpreted with caution, and ICI continuation could be considered for some patients. Insights: The antagonistic effect of glucocorticoids with ICI efficacy is transient and can be reverted when corticoids are withdrawn. Tumor progression in the context of the intercurrent use of systemic corticosteroids can be temporary and should be interpreted with caution, and ICI continuation could be considered for some patients.

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Fichiers liés : diagnostics-12-01933.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/01/2022
• Auteurs : Dorothée LussonMahaut DiganPhilippe GardèreFrancesca Di NapoliSébastien MilletNasser Djemmali
• Organismes : Institut national de recherches archéologiques préventives Cités, Territoires, Environnement et Sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Cités, Territoires, Environnement et Sociétés Institut national de recherches archéologiques préventives Cités, Territoires, Environnement et Sociétés Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives

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Résumé : Le diagnostic prescrit dans le cadre du projet d’aménagement de Bouygues-Immobilier sur la commune de Tours, Indre-et-Loire au 37 av. Gustave Eiffel, rue Pierre et Marie Curie et rue de Belgique concerne une surface de 53 140 m2. Deux séquences de limon des plateaux (LP) sont attestées dans ce secteur et présentent un intérêt particulier pour le Paléolithique. Le taux d’ouverture à 9 % de la surface accessible jusqu’aux séquences recélant potentiellement des occupations anciennes est inédit sur la zone envisagée. La recherche des indices paléolithiques étant habituellement cantonnée à un maillage tous les 50 m de sondages profonds en puits. L’intérêt majeur de cette intervention réside dans la mise en évidence d’indices attribués au Paléolithique moyen venant confirmer le potentiel très important de ce secteur au Nord de Tours : 3 concentrations de matériel lithique et un paléochenal ayant piégé du mobilier bien conservé. Il semble que deux phases chronologiques se distinguent au sein des concentrations mises au jour avenue Eiffel. En effet, la concentration 3 revêt un intérêt particulier puisqu’elle est située à la base de la séquence 2 des LP, alors que les autres se localisent au sein de l’horizon ferro-manganique au sommet de la séquence 1. L’axe d’écoulement du paléochenal, son tracé, sa largeur et sa profondeur qui auraient permis de mieux cibler les berges recélant potentiellement des niveaux d’occupations bien conservés n’ont pu être précisés en raison des zones polluées ou inaccessibles au moment du diagnostic. La découverte de ces occupations du Paléolithique moyen présente un intérêt tout particulier en raison de l’homogénéité et de la bonne conservation des assemblages lithiques. Cependant, beaucoup de questions restent posées concernant l’attribution culturelle, l’étendue des occupations et l’interaction entre les différentes concentrations lithiques mises au jour. Par ailleurs, les quelques indices d’occupations de la fin de l’âge du fer viennent conforter la vision d’un plateau mis en valeur en vue d’une exploitation agro-pastorale déjà largement attestée par les diagnostics et fouilles récentes sur la zone.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Didier BertViolaine BousquetMyette GuiomarFrancesco BarianiEmmanuel FaureJean-Claude HippolytePhilippe BrombletJean-Luc GarciazJules FleuryPatrick MathieuJean-Simon PagèsPierre TardieuMaud Dupuis-CaillotKimberly Leong
• Organismes : Réserve naturelle nationale géologique de Haute-Provence Géosciences Rennes Service Environnement, Conseil départemental des Alpes de Haute-Provence Réserve naturelle nationale géologique de Haute-Provence Réserve naturelle nationale géologique de Haute-Provence Réserve naturelle nationale géologique de Haute-Provence Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Interdisciplinaire de Conservation et de Restauration du Patrimoine Laboratoire d'Etudes et de Recherches sur les Materiaux Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Direction du Développement, de l’Environnement et de l’Eau - Département des Alpes de Haute-Provence UNESCO Géoparc de Haute-Provence ECOxygène Polymorphe Design Réserve naturelle nationale géologique de Haute-Provence
• Publié dans Geoheritage le 13/11/2020

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Résumé : Protected under National Nature Reserve, managed by the Departmental Council of the Alpes de Haute-Provence, and labeled UNESCO Geopark, the Ammonites Slab of Digne-les-Bains (SE France) exhibits 1,550 ammonites over a large open-air surface. Despite the virtual absence of special enhancement for the visitors, this spectacular geosite of high scientific and heritage value has played an important role in the years 1990–2000 in the emergence of notions of geological heritage, geological nature reserve, geotourism, and Geopark. Due to its exposure to mountain weather conditions, the Slab suffers from significant conservation issues. Several studies have shown that its condition was much worse than expected. Without major restoration work, the Slab was in danger of collapse in the short term. Given the high cost of the needed rescue work, the geotourism project “The Geological Adventure” was developed under European Interreg ALCOTRA funding. More broadly, this project aims to develop a sustainable experiential geotourism around the geoheritage of the Southwestern Alps cross-border (France–Italy), partly in situ and thanks to digital tools (22 geosites concerned). An important place is given to scientific pedagogy. Concerning the Ammonites Slab, the project consisted of (1) stabilizing and ensuring the sustainability of the fossiliferous layer; (2) planning and developing the overall geosite (parking area, reception area, observation platform); (3) allowing accessibility for people with disabilities; and (4) offering progressive and immersive educational mediation to make scientific culture accessible to as many people as possible.

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Fichiers liés : The ammonite slab of Digne_revised-clean.pdf

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