Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 25/01/2026
• Auteurs : Jean-Michel LettSarah ScusselSélim Ben ChéhidaMurielle HoareauDenis FillouxEmmanuel FernandezPhilippe RoumagnacEvelyne ParvedyElise QuirinClarisse ClainJanice MinatchyEstelle RouxPierre-Yves TeycheneyPierre Lefeuvre
• Organismes : Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Plant Health Institute of Montpellier Plant Health Institute of Montpellier Fédération départementale des groupements de défense contre les organismes nuisibles SCA Fruits de La Réunion Fédération départementale des groupements de défense contre les organismes nuisibles Fédération départementale des groupements de défense contre les organismes nuisibles Fédération départementale des groupements de défense contre les organismes nuisibles Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical
• Publié dans Archives of Virology le 27/10/2020

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Résumé : Using unbiased high-throughput sequencing for metagenomic screening of viruses in diseased tomato plants, we identified a viral complex that includes viruses previously reported in tomato crops on La Réunion Island as well as a novel polerovirus, tentatively named "tomato necrotic yellowing virus" (ToNYV, proposed species, "Polerovirus ToNYV"). Molecular characterization and phylogenetic analysis revealed that ToNYV is closely related to two recently described poleroviruses from Africa and the Middle East, one of which is transmitted by the whitefly Bemisia tabaci, a trait uncommon among poleroviruses. Our transmission experiments demonstrated that ToNYV is also transmitted by B. tabaci and is prevalent across major tomato-growing regions of La Réunion. These findings highlight the value of metagenomic virome analysis in diseased plants for identifying novel viruses potentially involved in emerging plant diseases, either individually or as components of viral complexes.

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Fichiers liés : s00705-025-06426-y.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/01/2026
• Auteurs : Claire S TeitelbaumDiann J ProsserJoshua T AckermanSakib AhmedA B M Sarowar AlamKazi Zenifar AzmiriNyambaya BatbayarJoël BêtyAbigail Blake‐bradshawDmitrijs BoikoNelleke H. BuitendijkJeffrey J BulerDavid CabotMichael L CasazzaBradley CohenBatmunkh DavaasurenSébastien FarauJamie FeddersenJohn FiebergWolfgang FiedlerPeter M GlazovLarry R GriffinMatthieu GuillemainHeath HagyMatthew J HardyCory HighwayDavid HoffmanTehan KangAllison KeeverJennifer KilburnAndrea KölzschHelmut KruckenbergToni LaaksonenBrian S LadmanHansoo LeeSiwan LeeJosée LefebvrePierre LegagneuxHans LinssenJesper MadsenNicholas M MastoScott McwilliamsTori Mezebish QuinnCarl MitchellAxelle MoreauGerhard MüskensScott NewmanBart A. NoletRascha J M NuijtenJay OsenkowskiCory T OvertonAntti PiironenBetty PlaquinAndrew M RameyJean RodrigueDavid RodriguesKees H T SchrevenYali SiJeffery D SullivanJohn TakekawaPhilippe J ThomasMariëlle van ToorJonas WaldenströmChristopher K WilliamsDavid William WolfsonFei XuIan G BrosnanSusan E W de la Cruz
• Organismes : Service conservation et gestion durable des espèces exploitées Service conservation et gestion durable des espèces exploitées
• Publié dans Ecology Letters le 02/11/2020

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Résumé : ABSTRACT Animal movements contribute to the spread of infectious diseases and are driven in part by environmental conditions. We investigated the links among the environment, animal movement, and infectious disease dynamics in waterfowl, which are among the primary wildlife hosts of avian influenza viruses. By combining telemetry data on 4606 individuals from 26 waterfowl species with data on land cover, weather, and vegetation, we found that waterfowl moved less in areas of higher land cover heterogeneity and higher human population density. Moreover, predicted waterfowl movement distances were weakly but positively correlated with distances between detections of H5N1 highly pathogenic avian influenza in wild waterfowl, suggesting that environmental conditions might contribute to the spread of this disease via their effects on bird movements. By considering wildlife movements alongside other drivers of infectious disease dynamics, such as livestock production and human mobility, we move closer to predicting outbreaks and informing interventions.

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Fichiers liés : Ecology Letters 2026 Waterfowl movement.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/01/2026
• Auteurs : Olivia LenoirFlorence MorinAnouk Walter-PetrichLéa ResminiMohamad ZaidanNassim MahtalPierre-Alexandre JustVictor PuellesNicola WannerJulien DangThibaut d'Izarny-GargasJana BiermannBenjamin IzarStéphanie BaronBenjamin TerrierZiad MassyMarie EssigAymeric CouturierOlivia MayXavier BelenfantDavid BuobIsabelle BrocheriouHassan IzzedineYannis LombardiHélène FrançoisAnissa MoktefiVincent AudardAurélie SannierEric DaugasMatthieu JammeGuylaine HenryIsabelle Le Monnier de GouvilleCatherine MarieLaurence HomyrdaCéline VerstuyftSarah TubianaOuifiya KafifValentine PiquardMaxime DougadosTobias Bruno HuberMarine LivrozetJean-Sébastien HulotCédric LaouénanJade GhosnFrance MentréAlexandre KarrasYazdan YazdanpanahRaphaël PorcherPhilippe RavaudSophie Caillat-ZucmanXavier MarietteOlivier HermineMatthieu Resche-RigonPierre-Louis Tharaux
• Organismes : Paris-Centre de Recherche Cardiovasculaire Hôpital Universitaire Carémeau [Nîmes] Université Paris Cité AP-HP - Hôpital Saint-Louis [Paris] Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) Paris-Centre de Recherche Cardiovasculaire AP-HP - Hôpital Bicêtre [Le Kremlin-Bicêtre] Paris-Centre de Recherche Cardiovasculaire AP-HP - Hôpital Bicêtre [Le Kremlin-Bicêtre] Université Paris-Saclay Assistance publique - Hôpitaux de Paris Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] AP-HP - Hôpital Ambroise Paré UFR Sciences de la santé Simone Veil AP-HP - Hôpital Bicêtre [Le Kremlin-Bicêtre] Paris-Centre de Recherche Cardiovasculaire Columbia University [New York] Columbia University [New York] Service de Physiologie, Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, France Assistance publique - Hôpitaux de Paris AP-HP - Hôpital Européen Georges Pompidou AP-HP - Hôpital Cochin AP-HP - Hôpital Ambroise Paré AP-HP - Hôpital Ambroise Paré CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Centre Hospitalier Intercommunal André Grégoire [Montreuil] Centre Hospitalier Intercommunal André Grégoire [Montreuil] AP-HP - Hôpital Européen Georges Pompidou CIC - HEGP CIC - HEGP AP-HP - Hôpital Européen Georges Pompidou Université Paris Cité, INSERM, PARCC (Paris Cardiovascular Research Center), France Paris-Centre de Recherche Cardiovasculaire Institut National de la Santé et de la Recherche Médicale UFR Médecine [Santé] - Université Paris Cité
• Publié dans JCI Insight le 27/10/2020

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Résumé : After identifying 2 immunomarkers of acute injury, KIM-1 and LCN2, in all kidney biopsies from 31 patients with COVID-19 pneumonia and de novo kidney dysfunction, we investigated whether circulating markers of kidney epithelial injury are common in patients with laboratory-confirmed COVID-19 who require oxygen support but do not have critical illness.METHODSWe studied 196 patients admitted to 15 hospitals with moderate to severe pneumonia who were enrolled in 2 independent randomized clinical trials. We measured 41 immune mediators and markers of kidney and endothelial injury in peripheral blood in these patients within 24 hours of randomization.RESULTSWe constructed a generalized linear CORIMUNO model combining serum levels of KIM-1, LCN2, IL-10, and age at hospital admission that showed high discrimination for mortality (derivation cohort: AUC = 0.82, 95% CI: 0.73-0.92; validation cohort: AUC = 0.83, 95% CI: 0.74-0.92). An early rise in circulating kidney injury markers, in the absence of acute kidney injury criteria, was markedly associated with the risk of developing a severe form of COVID-19 and death within 3 months.CONCLUSIONThe CORIMUNO score may be a helpful tool for risk stratification, and for the first time to our knowledge, it identifies the overlooked impact of subclinical kidney injury on pneumonia outcomes.TRIAL REGISTRATIONClinicalTrials.gov NCT04324047, NCT04324073, and NCT04331808.FUNDINGThis research was funded by the French Ministry of Health, Programme Hospitalier de Recherche Clinique (PHRC COVID-19-20-0151, PHRC COVID-19-20-0029), Fondation de l'Assistance Publique Hôpitaux de Paris (Alliance Tous Unis Contre le Virus), Assistance Publique Hôpitaux de Paris, and grants from the Fondation pour la Recherche Médicale (FRM) (REA202010012514) and Agence Nationale de Recherches sur le Sida and emerging infectious diseases (ANRS) (ANRS0147) from the VINTED sponsorship.

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• Type de publi. : Article dans une revue
• Date de publi. : 22/01/2026
• Auteurs : Jean FurstossDaniel Pino MuñozPhilippe CarrezPierre HirelValentin DelbecqVahid SamaeeHosni IdrissiPatrick Cordier
• Organismes : Unité Matériaux et Transformations - UMR 8207 Centre National de la Recherche Scientifique Physique des Défauts et de la Plasticité [Institut Pprime] Centre de Mise en Forme des Matériaux Université de Lille Unité Matériaux et Transformations - UMR 8207 Université de Lille Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Universiteit Antwerpen = University of Antwerp Université Catholique de Louvain = Catholic University of Louvain Université de Lille Unité Matériaux et Transformations - UMR 8207
• Publié dans Communications Materials le 07/12/2020

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Résumé : Although stress-induced amorphization has recently been identified as a new and distinctive plasticity mechanism, a formal framework for its systematic application in materials engineering is still lacking. In this study, we establish that stress-induced amorphization in Mg2SiO4 forsterite exhibits all the key features of phase transformation plasticity, a well-known phenomenon that has enabled the development of high-performance materials. By analogy with the Transformation-Induced Plasticity (TRIP) effect, we introduce the concept of amorphous-TRIP (a-TRIP). We demonstrate that the a-TRIP features, in particular the orientation effect of stress-induced amorphization (particularly strong in forsterite), can be exploited to design materials with enhanced toughness, a notable advance for a class of materials traditionally limited by brittle behavior.

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Fichiers liés : 2026_Furstoss_Stress-Induced-Amorphization-TRIP-Forsterite.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 21/01/2026
• Auteurs : Lisa JustinianyLaurent SabatierJean-Philip BrugalCécile BaronPhilippe LasayguesPierre Magniez
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire méditerranéen de préhistoire Europe-Afrique Institut de Recherche sur les Phénomènes Hors Equilibre Laboratoire de Mécanique et d'Acoustique [Marseille] Aix Marseille Université Centrale méditerranée Laboratoire méditerranéen de préhistoire Europe-Afrique

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Résumé : During the Paleolithic, the bone marrow of herbivores constitutes a vital resource for human groups, especially during cold or periglacial contexts. Break the long bones of their prey (humerus, radius-ulna, femur, and tibia) to extract these essential nutritional and domestic byproducts is a frequent activity in many human societies. This behavior is well documented in many hunter-gatherers’ settlement, from Paleolithic to recent time with ethnographic studies. The analysis of bone breakage patterns stands a major data point for identifying game exploitation strategies, including the consumption and processing of ungulates by prehistoric peoples. It allows a better understanding of their cognitive abilities, technical skills, and socio economic behaviors, as well as a precise determination of site functions. However, to have a better resolution of this breakage process, it is imperative to have a thorough knowledge of the mechanical properties of the exploited material. In this study, we have analyzed 133 fragments of bovine (Bos taurus) from a corpus of 80 fractured long bones as part of an experimentation (IRN 0871 TaphEN) and an archaeological corpus of 56 long bone’s remains of Bison from a 161+/-14 kyr site: Coudoulous I level 4 (Lot, France). The fragments were analyzed according to three non-destructive methods: mass density, ultrasonic interferometry and micro-CT scanner. Through these various analytical protocols (LMA, Marseille), quantitative data regarding the morpho-structural properties of bones (density, porosity, acoustic velocity, impedance) have been obtained, highlighting intra- and inter-bone variability depending on different diaphyseal areas or bone portions. First results show that the radius-ulna is the most porous bone with low mass density; while the femur being the opposite: its compact structure promotes cleaner fractures. Archaeological remains are more porous with a significative low ultrasound velocity yet much high mass density, showing the influence of the bone fossilization process. This original and unprecedented multiphysical approaches in this field enhances our understanding of bone breakage. The objective of our study will be to further develop this cross disciplinary and collaborative work to better understand the breaking techniques used by prehistoric peoples and to better identify taphonomic biases (post-depositional preservation) by analyzing a corpus of fresh, dry, and fossil long bone fragments. The combination of actualistic, quantitative, experimental studies, based on modern and archaeo-paleontological remains, will allow for high-resolution analytics on human subsistence strategies thanks to a better understanding of ‘bone’ material.

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• Type de publi. : Rapport
• Date de publi. : 20/01/2026
• Auteurs : Aurélie CarodJulien AndrieuThierry TatoniRémi BeauAlexandra BiehlerJean-Jacques BrunJean-Christophe DISSARTPhilippe FajonAnne GanteaumeEmeline HattJean-Marc LangeLionel LaslazJacques LasseurNicolas LescureuxFrédéric LiébaultGregory LoucougarayPierre PechB. Talon
• Organismes : Études des Structures, des Processus d’Adaptation et des Changements de l’Espace Institut méditerranéen de biodiversité et d'écologie marine et continentale Institut d'écologie et des sciences de l'environnement de Paris École nationale supérieure d'architecture de Marseille Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Pacte, Laboratoire de sciences sociales Archéologies et Sciences de l'Antiquité Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Laboratoire Interdisciplinaire En Urbanisme Laboratoire Interdisciplinaire de Recherche en Didactique, Éducation et Formation Environnements, Dynamiques et Territoires de Montagne Systèmes d'élevage méditerranéens et tropicaux Norwegian Institute for Nature Research Éco-Anthropologie Centre d’Ecologie Fonctionnelle et Evolutive Institut des Géosciences de l’Environnement Laboratoire des EcoSystèmes et des Sociétés en Montagne Laboratoire Dynamiques Sociales et Recomposition des Espaces Institut méditerranéen de biodiversité et d'écologie marine et continentale

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Fichiers liés : 20250718_SST_WEB_BROCH.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/01/2026
• Auteurs : Alexandre TronelMorgane Roger-MargueritatCaroline PlazySalomé BiennierAnthony CraspayIpsita MohantyStéphanie Cools PortierManolo LaiolaGuus RoeselersNicolas MathieuMarianne HupePieter C DorresteinJean-Pierre AlcarazDonald K MartinPhilippe CinquinAnne-Sophie SilventJoris GiaiMarion ProustThomas SoranzoElena BuelowAudrey Le Gouellec
• Organismes : Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational microbial Evolution and Engineering Translational microbial Evolution and Engineering Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational microbial Evolution and Engineering CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble MaaT Pharma [Lyon] MetaGenoPolis Danone Nutricia Research [Utrecht] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Université de Genève = University of Geneva University of California [San Diego] Danone Research Skaggs School of Pharmacy and Pharmaceutical Sciences [San Diego] Collaborative Mass Spectrometry Innovation Center Colorado State University [Fort Collins] Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Université Grenoble Alpes Systèmes Nanobiotechnologiques et Biomimétiques Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 SIC Centre d'Investigation Clinique [Grenoble] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Modélisation et Évaluation des données complexes en Santé Publique Centre d'Investigation Clinique [Grenoble] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble Translational microbial Evolution and Engineering Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational microbial Evolution and Engineering Translational microbial Evolution and Engineering Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble
• Publié dans ISME Communications le 28/09/2021

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Résumé :

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Fichiers liés : ycaf224.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/01/2026
• Auteurs : Jeanne TamarelleMaria V DoriaValérie RambolamananaTatamo RajaonarivoAna Sousa FerreiraMaheninasy RakotondrainipianaRindra Vatosoa RandremananaPhilippe J SansonettiPascale VonaeschRobert BaroukiAlexandra BastaraudJean-Marc CollardMaria V DoriaDarragh DuffyB. Brett FinlaySerge Ghislain DjorieTamara Giles-VernickBolmbaye Privat GondjeJean-Chrysostome GodyMilena HasanNathalie KapelJean-Pierre LombartSynthia Nazita NigatoloumLaura Wegener ParfreyMaheninasy RakotondrainipianaRindra Vatosoa RandremananaAnnick RobinsonPierre-Alain RubboLaura SchaefferIonela Gouandjika-VasilacheSonia Sandrine VondoInès Vigan-Womas
• Organismes : Université de Lausanne = University of Lausanne Institut Pasteur [Paris] Institut Pasteur de Madagascar Institut Pasteur de Madagascar Universidade de Lisboa = University of Lisbon = Université de Lisbonne [Lisboa] Instituto Universitário de Lisboa Institut Pasteur de Madagascar Institut Pasteur de Madagascar Pathogénie microbienne moléculaire Université de Lausanne = University of Lausanne AP-HP - Hôpital Necker - Enfants Malades Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur [Paris] Institut Pasteur [Paris] University of British Columbia [Canada] Institut Pasteur de Bangui Institut Pasteur [Paris] Centre pédiatrique de Bangui Centre pédiatrique de Bangui Institut Pasteur [Paris] AP-HP - Hôpital de la Pitié Salpêtrière Institut Pasteur de Bangui Centre pédiatrique de Bangui University of British Columbia [Canada] Institut Pasteur de Madagascar Institut Pasteur de Madagascar Centre Hospitalier Universitaire Mère-Enfant de Tsaralalàna Institut Pasteur de Bangui Institut Pasteur [Paris] Institut Pasteur de Bangui Centre pédiatrique de Bangui Institut Pasteur de Madagascar
• Publié dans Scientific Reports le 26/10/2020

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Résumé : In 2024, stunted child growth affected 150 million children under the age of five years, underscoring its critical impact on global health. Stunting has also been associated with neurodevelopmental delays. This study explores the relationship between stunting, the fecal microbiota, and neurodevelopment in 2–5-year-old children from the Afribiota cross-sectional study in Madagascar. Children were assessed using the Ages and Stages Questionnaire (ASQ-3), covering five developmental domains (communication, personal-social, problem-solving, fine and gross motor). Fecal samples were analyzed via 16S rRNA gene amplicon sequencing. Classical bi- and multivariate analysis was combined with Structural Equation Modelling to evaluate direct and indirect associations between different clinical factors, the microbiota and neurodevelopment. Our study shows that stunting and low socioeconomic status are consistently linked to poorer neurodevelopmental outcomes, while low branched-chain amino acids and hemoglobin levels are associated with stunting. Furthermore, a higher microbial diversity within individuals (α-diversity—specifically the Shannon index-) was directly linked to improved neurodevelopment scores in one of the tested models, while gut microbiota variation between individuals (β-diversity) was not associated with neurodevelopment. These findings support the hypothesis of neurodevelopment being primarily influenced by nutritional and social factors, with a more limited role for microbiota diversity.

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Fichiers liés : s41598-026-35174-5_reference.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2026
• Auteurs : Anaïs SchavgoulidzeAurore PerrotXavier LeleuTitouan CazaubielMarie-Lorraine ChretienPierre FeugierKarim BelhadjSalomon ManierMurielle RousselSabine BrechignacFrédérique Orsini-PiocelleMohamad MohtyJean Marc Schiano de ColellaMargaret MacroDidier AdikoMamoun DibJean FontanCarine Luttiau-MotardDidier BouscaryLaurent PascalVirginie RolandFrançois LifermannJana BakalaLydia MontesCéline KennelPhilippe ReyValentine RichezFaiza KeddarLaurent FrenzelClaire CalmettesCarine ChaleteixIsabelle PlantierÉmilie ChalayerAnna SchmittChristophe RoulHélène DemarquetteChloé CeruttiLuka PavageauLaure DerrierHervé Avet-LoiseauJill Corre
• Organismes : Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU de Bordeaux Pellegrin [Bordeaux] Service d'hématologie biologique [CHU de Dijon] Centre Hospitalier Régional Universitaire de Nancy AP-HP - Hôpital Henri-Mondor Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 CHU Limoges Service d'hématologie clinique [Avicenne] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] AP-HP - Hôpital Saint-Antoine Institut Paoli-Calmettes CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Libourne Hôpital Haut-Lévêque [CHU Bordeaux] Centre Hospitalier Universitaire d'Angers Hôpital Jean Minjoz [Besançon] Institut Cochin Hôpital Saint Vincent de Paul [Lille] Centre Hospitalier Dax - Côte d'Argent Centre Hospitalier de Lens Centre Hospitalier Universitaire d'Amiens-Picardie Service d'Accompagnement et Soins Palliatifs [CHU Limoges] Centre Léon Bérard [Lyon] Imagine - Institut des maladies génétiques (IHU) Centre Hospitalier de Périgueux CHU Clermont-Ferrand Hôpital Victor Provo [Roubaix] U 1059 – SAINBIOSE Bio-ingénierie Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] Institut de Cancérologie et d'Hématologie Universitaire de Saint-Étienne [CHU Saint-Etienne] Institut Bergonié [Bordeaux] Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Hôpital Claude Huriez [Lille] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Pôle IUCT [CHU Toulouse]
• Publié dans Blood le 28/10/2020

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Résumé : The prognostic heterogeneity of multiple myeloma is mainly driven by the genomic features of myeloma cells. The International Myeloma Society (IMS)/International Myeloma Working Group (IMWG) recently proposed a high-risk (HR) genomic model to have a consensus definition of genomic risk. We performed next-generation sequencing in the form of a panel on samples from 6528 patients with newly diagnosed multiple myeloma (NDMM) and 1583 patients at first relapse between 2019 and 2024. We observed that 22.4% of patients at diagnosis and 36.7% of patients at first relapse were classified as high risk according to the Consensus Genomic Staging. Clinical data were available for 2695 patients at diagnosis. After a median follow-up of 35 months, the median progression-free survival (PFS) was 30 months for patients with HR NDMM and 51 months for standard-risk (SR) patients (P< .0001). The HR cytogenetic criteria from the Revised- International Staging System score were not able to differentiate between HR and SR patients based on the IMS/IMWG genomic subgroups. Looking at each criterion independently, we found that the presence of del(17p), TP53 mutation, biallelic del(1p32), or the combination of intermediate-risk cytogenetics (gain 1q, del(1p32), t(4;14), t(14;16), t(14;20)) significantly reduced the PFS when compared with SR patients. Moreover, patients with several cumulating criteria had an even worse prognosis. Among SR patients, classified according to the genomic definition with normal creatinine, the median PFS for those with high β2-microglobulin was not significantly different from that of patients with normal β2-microglobulin level. This study validated the IMS/IMWG genomic definition of HR myeloma in a large cohort of patients diagnosed from 2019 onwards.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2026
• Auteurs : Ryma BenrabahÉmilien GirotJean-Marc CommengeRené FournetPhilippe ArnouxPierre-Alexandre GlaudeBaptiste Sirjean
• Organismes : Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Département de Chimie Physique des Réactions Laboratoire Réactions et Génie des Procédés
• Publié dans Chemical Engineering Science le 29/10/2020

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Résumé : Liquid phase oxidation reactions are widely studied and optimized for industrial processes of interest such as the oxidation of cyclohexane. The slow oxidation of hydrocarbons, which takes place throughout their chain of use, is the cause of fuel deterioration known as fuel ageing. In recent years, the use of microfluidic tools for the investigation of such processes is expanding with the development of the technologies. Microfluidics enables the use of explosive conditions in a safer way than traditional processes and these tools can be adapted for the kinetic study of the oxidation of ground fuels and jet fuels. Their kinetics of oxidation are slow, and their study requires long residence times, which are not usually reached in the microfluidic field. The PEEK-ACHU rig, a microfluidic device with a heated silicon/glass microfluidic reactor designed for long residence times (from 16 min up to 230 min) and high pressure (up to 40 bar), was developed for the study of slow oxidation reactions of organic compounds. This work presents the design of the reactor and proposes a hydrodynamic study of the gas-liquid Taylor flow implemented in this tool to enable the study of oxidation reactions of fuels. A good understanding of the different diphasic flow regimes as a function of gas bubble generation was obtained for conditions in the explosive range. A correlation was found between the density and viscosity of a fuel and the length of gas bubbles and liquid slugs. The thickness of the residual liquid film at the wall and the reaction regime were characterized and demonstrate that the design of our microreactor enables the kinetic study of organic compounds oxidation, without oxygen mass transfer limitations, at high temperature and high pressure, for very long residence times.

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Fichiers liés : microfluidic_article_R1.pdf

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