Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 11/12/2021
• Auteurs : Matthieu SchmidtBertrand GuidetAlexandre DemouleMaharajah PonnaiahMuriel FartoukhLouis PuybassetAlain CombesDavid HajageAlain MercatPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PreauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DésertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonnièreDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre-Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérome PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSebastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultElie AzoulayMichael DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGael PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Tenon [AP-HP] Sorbonne Université - Faculté de Médecine Laboratoire d'Imagerie Biomédicale [Paris] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Centre Hospitalier Universitaire d'Angers LUNAM Université [Nantes Angers Le Mans] CHU d'Angers [Département Urgences] Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire d'Angers Fédération de Médecine Translationnelle de Strasbourg Nanomédecine Régénérative Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Faculté de Médecine Paris-Saclay Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine CHU Pitié-Salpêtrière [AP-HP] CHU Charles Foix [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique [GIN] Grenoble Institut des Neurosciences Université Grenoble Alpes [GIN] Grenoble Institut des Neurosciences
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Background: Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods: The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID-ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19. Machine learning was used to develop dynamic, clinically useful models able to predict 90-day mortality using ICU data collected on day (D) 1, D7 or D14. Results: Survival of Severely Ill COVID (SOSIC)-1, SOSIC-7, and SOSIC-14 scores were constructed with 4244, 2877, and 1349 patients, respectively, randomly assigned to development or test datasets. The three models selected 15 ICU-entry variables recorded on D1, D7, or D14. Cardiovascular, renal, and pulmonary functions on prediction D7 or D14 were among the most heavily weighted inputs for both models. For the test dataset, SOSIC-7's area under the ROC curve was slightly higher (0.80 [0.74-0.86]) than those for SOSIC-1 (0.76 [0.71-0.81]) and SOSIC-14 (0.76 [0.68-0.83]). Similarly, SOSIC-1 and SOSIC-7 had excellent calibration curves, with similar Brier scores for the three models. Conclusion: The SOSIC scores showed that entering 15 to 27 baseline and dynamic clinical parameters into an automatable XGBoost algorithm can potentially accurately predict the likely 90-day mortality post-ICU admission (sosic.shinyapps.io/shiny). Although external SOSIC-score validation is still needed, it is an additional tool to strengthen decisions about life-sustaining treatments and informing family members of likely prognosis.

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Fichiers liés : Schmidt_2021.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 11/12/2021
• Auteurs : Matthieu SchmidtBertrand GuidetAlexandre DemouleMaharajah PonnaiahMuriel FartoukhLouis PuybassetAlain CombesDavid HajageAlain MercatPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PréauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DesertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonnièreDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre-Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérome PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSébastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultÉlie AzoulayMichael DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGael PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID–ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19. Machine learning was used to develop dynamic, clinically useful models able to predict 90-day mortality using ICU data collected on day (D) 1, D7 or D14. Results Survival of Severely Ill COVID (SOSIC)-1, SOSIC-7, and SOSIC-14 scores were constructed with 4244, 2877, and 1349 patients, respectively, randomly assigned to development or test datasets. The three models selected 15 ICU-entry variables recorded on D1, D7, or D14. Cardiovascular, renal, and pulmonary functions on prediction D7 or D14 were among the most heavily weighted inputs for both models. For the test dataset, SOSIC-7’s area under the ROC curve was slightly higher (0.80 [0.74–0.86]) than those for SOSIC-1 (0.76 [0.71–0.81]) and SOSIC-14 (0.76 [0.68–0.83]). Similarly, SOSIC-1 and SOSIC-7 had excellent calibration curves, with similar Brier scores for the three models. Conclusion The SOSIC scores showed that entering 15 to 27 baseline and dynamic clinical parameters into an automatable XGBoost algorithm can potentially accurately predict the likely 90-day mortality post-ICU admission (sosic.shinyapps.io/shiny). Although external SOSIC-score validation is still needed, it is an additional tool to strengthen decisions about life-sustaining treatments and informing family members of likely prognosis.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 08/12/2021
• Auteurs : Matthieu SchmidtAlexandre DemouleDavid HajageTài PhamAlain CombesMartin DresSaid LebbahAntoine KimmounAlain MercatGaëtan BeduneauJessica PalmyreMargot PrevostJean-Damien RicardAlexis FerréPierre-Marie FayolleChristophe GiraultGael PradelPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PreauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DésertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonniereDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérome PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSebastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultElie AzoulayMichael DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGael PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahFlorence TubachNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Pitié-Salpêtrière [AP-HP] Neurophysiologie Respiratoire Expérimentale et Clinique Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Faculté de Médecine Paris-Saclay Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine Neurophysiologie Respiratoire Expérimentale et Clinique Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Défaillance Cardiovasculaire Aiguë et Chronique Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] Service de Réanimation Médicale [CHRU Nancy] Centre Hospitalier Universitaire d'Angers LUNAM Université [Nantes Angers Le Mans] CHU Rouen Groupe de Recherche sur le Handicap Ventilatoire Assistance publique - Hôpitaux de Paris (AP-HP) Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital Louis Mourier - AP-HP [Colombes] Infection, Anti-microbiens, Modélisation, Evolution Centre Hospitalier de Versailles André Mignot Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Service de Soins Intensifs [CHU Rouen] Groupe de Recherche sur le Handicap Ventilatoire Centre Hospitalier Henri Mondor d'Aurillac CHU d'Angers [Département Urgences] Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre hospitalier régional de Metz-Thionville Centre hospitalier régional de Metz-Thionville Centre hospitalier régional de Metz-Thionville Centre hospitalier régional de Metz-Thionville Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy [GIN] Grenoble Institut des Neurosciences Université Grenoble Alpes [GIN] Grenoble Institut des Neurosciences
• Publié dans Critical Care le 31/10/2020

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Résumé : Rational: To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate and mortality in COVID-19 patients admitted to intensive care units (ICUs). Methods: Multicenter, prospective cohort study (COVID-ICU) in 137 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, oxygenation failure, and survival data were collected. Oxygenation failure was defined as either intubation or death in the ICU without intubation. Variables independently associated with oxygenation failure and Day-90 mortality were assessed using multivariate logistic regression. Results: From February 25 to May 4, 2020, 4754 patients were admitted in ICU. Of these, 1491 patients were not intubated on the day of ICU admission and received standard oxygen therapy (51%), HFNC (38%), or NIV (11%) (P < 0.001). Oxygenation failure occurred in 739 (50%) patients (678 intubation and 61 death). For standard oxygen, HFNC, and NIV, oxygenation failure rate was 49%, 48%, and 60% (P < 0.001). By multivariate analysis, HFNC (odds ratio [OR] 0.60, 95% confidence interval [CI] 0.36-0.99, P = 0.013) but not NIV (OR 1.57, 95% CI 0.78-3.21) was associated with a reduction in oxygenation failure). Overall 90-day mortality was 21%. By multivariable analysis, HFNC was not associated with a change in mortality (OR 0.90, 95% CI 0.61-1.33), while NIV was associated with increased mortality (OR 2.75, 95% CI 1.79-4.21, P < 0.001). Conclusion: In patients with COVID-19, HFNC was associated with a reduction in oxygenation failure without improvement in 90-day mortality, whereas NIV was associated with a higher mortality in these patients. Randomized controlled trials are needed.

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Fichiers liés : Schmidt_2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2021
• Auteurs : Anna LevyWissam El-HageDjamila BennabiEtienne AllauzeAlexandra BouvardVincent CamusPhilippe CourtetJean-Michel DoreyB EtainGuillaume FondJean-Baptiste GentyJérôme HoltzmannMathilde HornMarion LeboyerPierre-Michel LlorcaManon MeyrelFanny MolièreAnne-Sophie NguonJean PetrucciRomain ReyRaphaelle RichieriFlorian StephanGuillaume VaivaMichel WalterEmmanuel HaffenBruno AouizerateAntoine Yrondi
• Organismes : Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Service Psychiatrie et psychologie médicale [CHU Toulouse] Imaging, Brain & Neuropsychiatry Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Fondation FondaMental [Créteil] Université Clermont Auvergne Fondation FondaMental [Créteil] Nutrition et Neurobiologie intégrée Imaging, Brain & Neuropsychiatry Fondation FondaMental [Créteil] Neuropsychiatrie : recherche épidémiologique et clinique Fondation FondaMental [Créteil] CHU Montpellier = Montpellier University Hospital Fondation FondaMental [Créteil] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Variabilité de réponse aux Psychotropes Fondation FondaMental [Créteil] Département de Psychiatrie et de Médecine Addictologique [AP-HP HU Saint-Louis, Lariboisière, Fernand Widal] Fondation FondaMental [Créteil] Hôpital de la Conception [CHU - APHM] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [CHU Lille] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux Fondation FondaMental [Créteil] Université Clermont Auvergne Hopital Saint-Louis [AP-HP] Fondation FondaMental [Créteil] Département de Psychiatrie et de Médecine Addictologique [AP-HP HU Saint-Louis, Lariboisière, Fernand Widal] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Service Psychiatrie et psychologie médicale [CHU Toulouse]
• Publié dans Frontiers in Psychiatry le 30/10/2020

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Résumé : Introduction: Treatment-resistant depression (TRD) is a disabling psychiatric condition characterized by the failure of two antidepressants (ADs). Since the occurrence of side effects (SEs) appears to be one of the main determinants of early discontinuation of pharmacological treatments contributing to a pseudo-resistance, the purpose of this study was to determine the parameters associated with the occurrence of SEs under ADs in a cohort of patients with TRD. Methods: An observational, cross-sectional, multicentre study was carried out using data from the French network of Expert Centers for TRD. For the 108 patients enrolled in the study, the statistical analyses focused on the overall occurrence and on the profile of the SEs (9 categories, 32 items). Results: SEs were influenced by age and sex and were positively associated with the intensity of anxious, depressive and suicidal symptoms, a history of childhood trauma (sexual abuse, emotional abuse and neglect), and negatively associated with self-esteem, and assessment of overall functioning. Conclusion: Using variables accessible in common practice, these results fall within the dynamic of a more tailored approach to medicine that could allow, through integrated pharmacological management, the continuation of antidepressant treatments, and therefore limit the risk of therapeutic failure.

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Fichiers liés : levv1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/12/2021
• Auteurs : Adeline FermanianPierre MarionJean-Philippe VertGérard Biau
• Organismes : Laboratoire de Probabilités, Statistique et Modélisation Laboratoire de Probabilités, Statistique et Modélisation Google Research [Paris] Laboratoire de Probabilités, Statistique et Modélisation

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Résumé : Building on the interpretation of a recurrent neural network (RNN) as a continuoustime neural differential equation, we show, under appropriate conditions, that the solution of a RNN can be viewed as a linear function of a specific feature set of the input sequence, known as the signature. This connection allows us to frame a RNN as a kernel method in a suitable reproducing kernel Hilbert space. As a consequence, we obtain theoretical guarantees on generalization and stability for a large class of recurrent networks. Our results are illustrated on simulated datasets.

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Fichiers liés : 2106.01202.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/12/2021
• Auteurs : Aurélie CambouPhilippe ThalerAnne Clément-VidalBernard G. BarthèsFabien CharbonnierKarel van den MeerscheMaria Aguilar VegaJacques AvelinoFabrice DavrieuxJean-Pierre LabouisseElias de Melo Virginio FilhoPhilippe DeleporteDidier BrunetPeter LehnerOlivier Roupsard
• Organismes : Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Département Performances des systèmes de production et de transformation tropicaux Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Consejo Nacional de Ciencia y Tecnología [Mexico] Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center Plant Health Institute of Montpellier Département Systèmes Biologiques Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center Démarche intégrée pour l'obtention d'aliments de qualité Département Performances des systèmes de production et de transformation tropicaux Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Cafetalera Aquiares Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Département Performances des systèmes de production et de transformation tropicaux Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center LMI IESOL Intensification Ecologique des Sols Cultivés en Afrique de l’Ouest [Dakar]
• Publié dans Tree Physiology le 29/10/2020

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Résumé : In coffee, fruit production on a given shoot drops after some years of high yield, triggering pruning to induce resprouting. The timing of pruning is a crucial farmer’s decision affecting yield and labour. One reason for fruit production drop could be the exhaustion of resources, particularly the non-structural carbohydrates (NSC). To test this hypothesis in a Coffea L. arabica agroforestry system, we measured the concentrations of NSC, carbon (C) and nitrogen (N) in leaves, stems and stumps of the coffee plants, 2 and 5 years after pruning. We also compared shaded vs full sun plants. For that purpose, both analytical reference and visible and near infrared reflectance spectroscopy (VNIRS) methods were used. As expected, concentrations of biochemical variables linked to photosynthesis activity (N, glucose, fructose, sucrose) decreased from leaves to stems, and then to stumps. In contrast, variables linked more closely to plant structure and reserves (total C, C:N ratio, starch concentration) were higher in long lifespan organs like stumps. Shading had little effect on most measured parameters, contrary to expectations. Concentrations of N, glucose and fructose were higher in 2-year-old organs. Conversely, starch concentration in perennial stumps was three times higher 5 years after pruning than 2 years after pruning, despite high fruit production. Therefore, the drop in fruit production occurring after 5–6 years was not due to a lack of NSC on plant scale. Starch accumulation in perennial organs concurrently to other sinks, such as fruit growth, could be considered as a ‘survival’ strategy, which may be a relic of the behaviour of wild coffee (a tropical shade-tolerant plant). This study confirmed that VNIRS is a promisingly rapid and cost-effective option for starch monitoring (coefficient of determination for validation, R2val = 0.91), whereas predictions were less accurate for soluble sugars, probably due to their too similar spectral signature.

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Fichiers liés : 2021CambouVandenMeerscheRoupsardetalstarchincoffee.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/12/2021
• Auteurs : Antoine DevalckeneerRabih AboukaisMaxime FaisantPhilippe BourgeoisQuentin Vannot-MichelClaude-Alain MaurageFabienne NarducciJean-Paul Lejeune
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189
• Publié dans Neurosurgical Review le 01/11/2020

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Résumé : WHO grade II progestin-related meningiomas have been reported in recent series but we found no previous study describing their long-term outcome. Our study aimed to evaluate patients operated on for high-grade intracranial meningioma and who underwent long-term exposure to high dose of cyproterone acetate, nomegestrol acetate, and chlormadinone acetate. Our study retrospectively included 9 patients with high-grade progestin-related intracranial meningioma between December 2006 and September 2021. In each patient, clinico-radiological follow-up was performed every 6 months after diagnosis and treatment withdrawal recommendation. The mean progestative exposure was 11.4 years. Edema existence or absence of cleft sign on MRI were the key factors for surgical indication. All patients underwent surgery. Adjuvant radiotherapy was indicated in 1 patient, and Gamma Knife radiosurgery was proposed in 2 other patients for a second location of meningioma. Six patients harbored a grade II chordoid meningioma subtype with 100% PR expression and 3 patients a grade II atypical meningioma subtype with lower PR expression. The mean follow-up was 8.1 years and none of the 9 patients presented with a recurrence. Patients with grade II progestin-related meningiomas have less tumor recurrence after surgery than patients with sporadic grade II meningiomas, especially after progestin withdrawal. The presence/appearance of peri-meningioma edema and the absence of cleft sign before volumetric change should suggest the existence of an underlying WHO grade II meningiomas. In these cases, surgical resection may immediately be considered and adjuvant radiotherapy should be reserved for proven recurrence cases.

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• Type de publi. : Article dans une revue
• Date de publi. : 03/12/2021
• Auteurs : Jan-Hinnerk MehrkensMarion HouotCharlotte RossoStéphanie CarvalhoThomas NedelecRedwan MaatougVictor PitronSalimata GassamaSara SambinStéphanie BomboisBastien HerlinGaëlle OuvrardGaëlle BruneteauAdèle HestersAna Zenovia GalesBruno MilletFoudil LamariStéphane LehéricyVincent NavarroBenjamin RohautSophie DemeretThierry MaisonobeMarion YgerBertrand DegosLouise-Laure MarianiChristophe BoucheNathalie DzierzynskiBruno OquendoFlora KetzAn-Hung NguyenAurélie KasCatherine LubetzkiJean-Yves DelattreJean-Christophe CorvolBertrand FontainePhilippe ThoumieTarek SharsharSonia AlamowitchEmmanuelle ApartisCharles-Siegried PerettiRenata UrsuKiyoka Kinugawa BourronJoël BelminEric PautasMarc VernyYves SamsonSara LederAnne LegerSandrine DeltourFlore BaronnetMehdi TouatMarc SansonCaroline DehaisCaroline HouillierFlorence Laigle-DonadeyDimitri PsimarasAgusti AlentonNadia YounanNicolas VillainMaria del Mar AmadorNicolas MezouarGraziella MangoneAurelie MeneretAndreas HartmannClement TarranoDavid BendetowiczPierre-François PradatMichel BaulacPhintip PichitFlorence Chochonan Hung NguyenValerie PorcherAlexandre DemouleElise MorawiecJulien MayauxMorgan FaureClaire EwenczykGiulia CoarelliAnna HeinzmannMarion MasingueGuillaume BassezIsabelle AnYulia WorbeVirginie LambrecqRabab DebsEsteban Munoz-MusatTimothee LengletAurelie HaninLydia ChougarNathalia ShorNadya PyatigorskayaDamien GalanaudDelphine LeclercqAlbert CaoClemence MaroisNicolas WeissLoic Le GuennecVincent DegosAlice JacquensThomas SimilowskiCapucine Morelot-PanziniJean-Yves RotgeBertrand SaudreauNassim SarniNathalie GiraultSmaranda LeuLionel ThivardKarima MokhtariIsabelle PluBruno GonçalvesLaure BottinRebecca HaddadCarmelo LafuenteChristel OasiBruno MegabarneDominique HerveHaysam SalmanArmelle Rametti-LacrouxAlize ChalançonAnais HerveHugo RoyerFlorence BeauzorValentine MaheoChristelle LaganotCamille MinelliAurelie FeketeAbel GrineMarie BietRania HilabAurore BesnardMeriem BouguerraGwen GoudardSaida HouairiSaba Al-YoussefChristine PiresAnissa OukhedoumaKatarzyna Siuda-KrzywickaTal Seidel MalkinsonHanane AgguiniSafia SaidAna Zenovia GalesVanessa Batista BrochardKiyoka Kinugawa BourronAn Hung NguyenEsteban Munoz MusatTal Seidel Malkinson
• Organismes : Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Rothschild [AP-HP] Centre de recherche en Myologie – U974 SU-INSERM CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Saint-Antoine [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute
• Publié dans Brain Communications le 08/02/2021

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Résumé : A variety of neuropsychiatric complications has been described in association with COVID-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with COVID-19 seen in a multidisciplinary hospital centre over 6 months. We conducted a retrospective, observational study of all patients showing neurological or psychiatric symptoms in the context of COVID-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris-Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of COVID-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 COVID-19 patients with a de novo neurological or psychiatric manifestation were included in the database and 245 were included in the final analyses. One-hundred fourteen patients (47%) were admitted to the intensive care unit and 10 (4%) died. The most frequent neuropsychiatric complications diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%) and cerebrovascular disorders (16%). No patients showed CSF evidence of SARS-CoV-2. Encephalopathy was associated with older age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the intensive care unit. The majority of these neuropsychiatric complications could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.

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Fichiers liés : fcab135.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/12/2021
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiAntonio Fernandez DumontFrancisco Javier Moreno
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : This Scientific Opinion addresses the formulation of specific development needs, including research requirements for allergenicity assessment and protein safety, in general, which is urgently needed in a world that demands more sustainable food systems. Current allergenicity risk assessment strategies are based on the principles and guidelines of the Codex Alimentarius for the safety assessment of foods derived from 'modern' biotechnology initially published in 2003. The core approach for the safety assessment is based on a 'weight-of-evidence' approach because no single piece of information or experimental method provides sufficient evidence to predict allergenicity. Although the Codex Alimentarius and EFSA guidance documents successfully addressed allergenicity assessments of single/ stacked event GM applications, experience gained and new developments in the field call for a modernisation of some key elements of the risk assessment. These should include the consideration of clinical relevance, route of exposure and potential threshold values of food allergens, the update of in silico tools used with more targeted databases and better integration and standardisation of test materials and in vitro/in vivo protocols. Furthermore, more complex future products will likely challenge the overall practical implementation of current guidelines, which were mainly targeted to assess a few newly expressed proteins. Therefore, it is timely to review and clarify the main purpose of the allergenicity risk assessment and the vital role it plays in protecting consumers' health. A roadmap to (re)define the allergenicity safety objectives and risk assessment needs will be required to inform a series of key questions for risk assessors and risk managers such as 'what is the purpose of the allergenicity risk assessment?' or 'what level of confidence is necessary for the predictions?'.

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Fichiers liés : EFSA Journal - 2022 - - Scientific Opinion on development needs for the allergenicity and protein safety assessment of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Vitalii TkachenkoPhilippe KunemannJean Pierre MalvalJean-Pierre MalvalTatiana PetithoryLaurent PieuchotLoïc VidalAbraham Chemtob
• Organismes : Université de Haute-Alsace (UHA) Mulhouse - Colmar
• Publié dans Nanoscale le 27/10/2020

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Résumé : Self-assembled block copolymer nanoparticles (NPs) have emerged as a major potential nanoscale vehicle for fluorescence bioimaging purpose. Crucial to their practical implementation is to prepare with high yields NPs possessing a high kinetic stability to prevent the leakage of fluorophore molecules. Here, we report a photomediated RAFT polymerization-induced self-assembly (PISA) yielding uniform and nanosized poly((oligo(ethylene glycol) acrylate)-block-poly(benzyl acrylate) particles (POEGA-b-PBzA) with a concentration of 22 w%, over 20 times more than micellization and nanoprecipitation. The spherical diblock copolymer nanoparticles have an average size of 10-50 nm controllable through the degree of polymerization of the stabilizing POEGA block. Subsequent dialysis against water and swelling with Nile red solution lead to highly stable fluorescent NPs able to withstand changes in concentration, ionic strength, pH or temperature. The PBzA/water interfacial tension of 48.6 mN/m hinders the exchange between copolymer chains, resulting in the trapping of NPs in a “kinetically frozen” state responsible for the high stability. A spectroscopic study combining fluorescence and UV-vis absorption agrees with a preferential distribution of fluorophore in the outer POEGEA shell despite its hydrophobic nature. Nile red-doped POEGA-b-PBzA micelles stripped of initiator residue and unimers with high structural stability turn out to be non cytotoxic, and can be used for the optical imaging of cells. Real-time confocal fluorescent microscopy shows a fast cellular uptake using C2C12 cell lines in the matter of minutes, and a preferential localization in the perinuclear region, in particular in the vesicles

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Fichiers liés : Manuscript-n5-Vitalii-v24-HAL.pdf

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