Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : A. ZhukovMarilena MierlaFrédéric AuchèreSamuel GissotLuciano RodriguezElie SoubriéWilliam ThompsonBernd InhesterBogdan NiculaPatrick AntolinSusanna ParentiEric BuchlinKrzysztof BarczynskiCis VerbeeckEmil KraaikampPhilip SmithKoen StegenLaurent DollaL. HarraDavid LongU. SchühleOlena PodladchikovaRegina Aznar CuadradoLuca TeriacaMargit HaberreiterAthanassios KatsiyannisPierre RochusJean-Philippe HalainLionel JacquesDavid Berghmans
• Organismes : Solar-Terrestrial Centre of Excellence [Brussels] D.V. Skobeltsyn Institute of Nuclear Physics Solar-Terrestrial Centre of Excellence [Brussels] Institut d'astrophysique spatiale Solar-Terrestrial Centre of Excellence [Brussels] Solar-Terrestrial Centre of Excellence [Brussels] Institut d'astrophysique spatiale Universitat de les Illes Balears = Universidad de las Islas Baleares = University of the Balearic Islands ADNET Systems, Inc. Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Solar Influences Data Analysis Center [Brussels] Northumbria University [Newcastle] Institut d'astrophysique spatiale Institut d'astrophysique spatiale Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Department of Physics = Departement Physik [ETH Zürich] Solar-Terrestrial Centre of Excellence [Brussels] Solar-Terrestrial Centre of Excellence [Brussels] Mullard Space Science Laboratory Solar-Terrestrial Centre of Excellence [Brussels] Solar-Terrestrial Centre of Excellence [Brussels] Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Department of Physics = Departement Physik [ETH Zürich] Mullard Space Science Laboratory Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Solar Influences Data Analysis Center [Brussels] Centre Spatial de Liège Agence Spatiale Européenne = European Space Agency Centre Spatial de Liège Centre Spatial de Liège Solar-Terrestrial Centre of Excellence [Brussels]
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. The three-dimensional fine structure of the solar atmosphere is still not fully understood as most of the available observations are taken from a single vantage point. Aims. The goal of the paper is to study the three-dimensional distribution of the small-scale brightening events (“campfires”) discovered in the extreme-UV quiet Sun by the Extreme Ultraviolet Imager (EUI) aboard Solar Orbiter. Methods. We used a first commissioning data set acquired by the EUI’s High Resolution EUV telescope on 30 May 2020 in the 174 Å passband and we combined it with simultaneous data taken by the Atmospheric Imaging Assembly (AIA) aboard the Solar Dynamics Observatory in a similar 171 Å passband. The two-pixel spatial resolution of the two telescopes is 400 km and 880 km, respectively, which is sufficient to identify the campfires in both data sets. The two spacecraft had an angular separation of around 31.5° (essentially in heliographic longitude), which allowed for the three-dimensional reconstruction of the campfire position. These observations represent the first time that stereoscopy was achieved for brightenings at such a small scale. Manual and automatic triangulation methods were used to characterize the campfire data. Results. The height of the campfires is located between 1000 km and 5000 km above the photosphere and we find a good agreement between the manual and automatic methods. The internal structure of campfires is mostly unresolved by AIA; however, for a particularly large campfire, we were able to triangulate a few pixels, which are all in a narrow range between 2500 and 4500 km. Conclusions. We conclude that the low height of EUI campfires suggests that they belong to the previously unresolved fine structure of the transition region and low corona of the quiet Sun. They are probably apexes of small-scale dynamic loops heated internally to coronal temperatures. This work demonstrates that high-resolution stereoscopy of structures in the solar atmosphere has become feasible.

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Fichiers liés : aa41010-21.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Fabiana MadottoBairbre McnicholasEmanuele RezoagliTài PhamJohn LaffeyGiacomo BellaniAntonio PesentiJohn LaffeyLaurent BrochardAndres EstebanLuciano GattinoniFrank van HarenMarco RanieriGordon RubenfeldGordon RubenfeldB. Taylor ThompsonArthur SlutskyFernando RiosFrank van HarenMohammad Omar FaruqT. SottiauxP. DepuydtFredy LoraCesar Cesar AzevedoEddy FanGuillermo BugedoHaibo QiuMarcos GonzalezJuan SileskyVladimir CernyJonas NielsenManuel JibajaTài PhamHermann WriggeDimitrios MatamisJorge Luis RaneroCharles GomersallPravin AminS. HashemianKevin ClarksonGiacomo BellaniKiyoyasu KurahashiYounsuck KohAsisclo VillagomezAmine Ali ZeggwaghLeo HeunksJon Henrik LaakeWaqar KashifJorge SynclairJose Emmanuel PaloAntero Do Vale FernandesDorel SandescYaasen ArabiVesna BumbasierevicNicolas NinJose LorenteAnders LarssonLise PiquilloudBoonsong PatjanasoontornFekri AbrougDaniel McauleyLia McnameeJavier HurtadoEd BajwaGabriel DémpaireGuy FrancoisFrancesca RabboniFabiana MadottoSara ContiHektor SulaLordian NunciAlma CaniAlan ZazuChristian DelleraCarolina InsaurraldeRisso AlejandroJulio DaldinMauricio VinzioRuben FernandezLuis CardonnetLisandro BettiniMariano Carboni BissoEmilio OsmanMariano SettenPablo LovazzanoJavier AlvarezVeronica VillarNorberto PozoNicolas GrubissichGustavo PlotnikowDaniela VasquezSantiago IlutovichNorberto TiribelliAriel ChenaCarlos PellegriniMaría SaenzElisa EstenssoroMatias BrizuelaHernan GianinettoPablo GomezValeria CerratoMarco BezziSilvina BorelloFlavia LoiaconoAdriana FernandezSerena KnowlesClaire ReynoldsDeborah InskipJennene MillerJing KongChristina WhiteheadShailesh BihariAylin SevenAmanda KrstevskiHelen RodgersRebecca MillarToni MckennaIrene BaileyGabrielle HanlonAnders AnemanJoan LynchRaman AzadJohn NealPaul WoodsBrigit RobertsMark KolHelen WongKatharina RissThomas StaudingerXavier WitteboleCaroline BerghePierre BulpaAlain DiveRik VerstraeteHerve LebbinckPieter DepuydtJoris VermassenPhilippe MeerssemanHelga CeunenJonas RosaDaniel BeraldoClaudio PirasAdenilton RampinelliÑ NassarSergio MatalounMarcelo MoockMarlus ThompsonClaudio GonçalvesAna Carolina P. AntônioAline AscoliRodrigo BiondiDanielle FonteneleDanielle NobregaVanessa SalesSuresh ShindheDk Maizatul AimanBpg Hj IsmailJohn LaffeyFrancois BeloncleKyle DaviesRob CironeVenika ManoharanMehvish IsmailEwan GoligherMandeep JassalNiall FergusonErin NishikawaAreej JaveedGerard CurleyNuttapol RittayamaiMatteo ParottoSangeeta MehtaJenny KnollAntoine PronovostSergio CanestriniAlejandro BruhnPatricio GarciaFelipe AliagaPamela FaríasJacob YumhaClaudia OrtizJavier SalasAlejandro SaezLuis VegaEduardo LabarcaFelipe MartinezNicolás CarreñoPilar LoraHaitao LiuHaibo QiuLing LiuRui TangXiaoming LuoYouzhong AnHuiying ZhaoYan GaoZhe ZhaiZheng YeWei WangWenwen LiQingdong LiRuiqiang ZhengWenkui YuJuanhong ShenXinyu LiTao YuWeihua LuYa WuXiao HuangZhenyang HeYuanhua LuHui HanFan ZhangRenhua SunHua WangShu QinBao ZhuJun ZhaoJian LiuBin LiJing LiuFa ZhouQiong LiXing ZhangZhou Li-XinQiang Xin-HuaLiangyan JiangYuan GaoXian ZhaoYuan LiXiao LiChunting WangQingchun YaoRongguo YuKai ChenHuanzhang ShaoBingyu QinQing HuangWei ZhuAi HangMa HuaYimin LiYonghao XuYu DiLong LingTie QinShou WangJunping QinYi HanSuming ZhouMonica VargasJuan JimenezManuel RojasJaime Solis-QuesadaChristian Ramirez-AlfaroJan MácaPeter SklienkaJakob GjedstedAage ChristiansenJonas NielsenBoris VillamaguaMiguel LlanoPhilippe BurtinGautier BuzancaisPascal BeuretNicolas PelletierSatar MortazaAlain MercatJonathan ChellySébastien JochmansNicolas TerziCédric DaubinGuillaume CarteauxNicolas de ProstJean-Daniel ChicheFabrice DaviaudTài PhamMuriel FartoukhGuillaume BarberetJerome BiehlerJean DellamonicaDenis DoyenJean-Michel ArnalAnais BriquetFanny KlasenLaurent PapazianArnaud FollinDamien RouxJonathan MessikaEvangelos KalaitzisLaurence DangersAlain CombesSiu-Ming AuGaetan BéduneauDorothée CarpentierElie ZogheibHervé DupontSylvie RicomeFrancesco SantoliSebastien BessetPhilippe MichelBruno GeléePierre-Eric DaninBernard GoubauxPhilippe CrovaNga PhanFrantz BerkelmansJulio BadieRomain TapponnierJosette GallySamy KhebbebJean-Etienne HerbrechtFrancis SchneiderPierre-Louis DeclercqJean-Philippe RigaudJacques DuranteauAnatole HarroisRussell ChabanneJulien MarinJean-Michel ConstantinSandrine ThibaultMohammed GhaziMessabi BoukhaznaSalem Ould ZeinJack RichecoeurDaniele CombauxFabien GrelonCharlene Le MoalElise SauvadetAdrien RobineVirginie LemialeDanielle ReuterMartin DresAlexandre DemouleDany Goldgran-ToledanoLoredana BaboiClaude GuérinRalph LohnerJens KraßlerSusanne SchäferKai ZacharowskiPatrick MeybohmAndreas ReskePhilipp SimonHans-Bernd HopfMichael SchuetzThomas BaltusMetaxia PapanikolaouTheonymfi PapavasilopoulouGiannis ZacharasVasilis OurailogloyEleni MouloudiEleni MassaEva NagyElectra StamouEllada KiourtzievaMarina OikonomouLuis AvilaCesar CortezJohanna CitalánSameer JogSafal SableBhagyesh ShahMohan GurjarArvind BaroniaMohammedfaruk MemonRadhakrishnan MuthuchellappanVenkatapura RameshAnitha ShenoyRamesh UnnikrishnanSubhal DixitRachana RhayakarNagarajan RamakrishnanVallish BhardwajHeera MahtoSudha SagarVijayanand PalaniswamyDeeban GanesanSeyed Mohammadreza HashemianHamidreza JamaatiFarshad HeidariEdel MeaneyAlistair NicholKarl KnapmanDonall O’croininEimhin DunneDorothy BreenKevin ClarksonRola JaafarRory DwyerFahd AmirOlaitan AjetunmobiAogan O’muircheartaighColin BlackNuala TreanorDaniel CollinsWahid AltafGianluca ZaniMaurizio FusariSavino SpadaroCarlo VoltaRomano GrazianiBarbara BrunettiniSalvatore PalmesePaolo FormentiMichele UmbrelloAndrea LombardoElisabetta PecciMarco BotteriMonica SavioliAlessandro ProttiAlessia MatteiLorenzo SchiavoniAndrea TinnirelloManuel TodeschiniPoliclinico GiacconeAntonino GiarratanoAndrea CortegianiSara SherAnna RossiMassimo AntonelliLuca MontiniPaolo CasalenaSergio ScafettiGiovanna PanarelloGiovanna OcchipintiNicolò PatronitiMatteo PozziRoberto BiscioneMichela PoliFerdinando RaimondiDaniela AlbieroGiulia CrapelliEduardo BeckVincenzo PotaVincenzo SchiavoneAlexandre MolinFabio TarantinoGiacomo MontiElena FratiLucia MirabellaGilda CinnellaTommaso FossaliRiccardo ColomboPierpaolo Terragni Ilaria PattarinoFrancesco MojoliAntonio BraschiErika BorottoAndrea CracchioloDaniela PalmaFrancesco RaponiGiuseppe FotiEttore VascottoAndrea CoppadoroLuca BrazziLeda FlorisGiorgio IottiAaron VentiOsamu YamaguchiShunsuke TakagiHiroki MaeyamaEizo WatanabeYoshihiro YamajiKazuyoshi ShimizuKyoko ShiozakiSatoru FutamiSekine RyosukeKoji SaitoYoshinobu KameyamaKeiko UenoMasayo IzawaNao OkudaHiroyuki SuzukiTomofumi HarasawaMichitaka NasuTadaaki TakadaFumihito ItoShin NunomiyaKansuke KoyamaToshikazu AbeKohkichi AndohKohei KusumotoAkira HirataAkihiro TakabaHiroyasu KimuraShuhei MatsumotoUshio HigashijimaHiroyuki HondaNobumasa AokiHiroshi ImaiYasuaki OginoIchiko MizuguchiKazuya IchikadoKenichi NittaKatsunori MochizukiTomoaki HashidaHiroyuki TanakaTomoyuki NakamuraDaisuke NiimiTakeshi UedaYozo KashiwaAkinori UchiyamaOlegs SabelnikovsPeteris OssYoussef HaddadKong LiewSilvio Ñamendys-SilvaYves Jarquin-BadiolaLuis Sanchez-HurtadoSaira Gomez-FloresMaria MarinAsisclo VillagomezJordana LemusJonathan FierroMavy Ramirez CervantesFrancisco Javier Flores MejiaDulce DectorDulce DectorDaniel GonzalezClaudia EstrellaJorge Sanchez-MedinaAlvaro Ramirez-GutierrezFernando GeorgeJanet AguirreJuan BuensusesoManuel PoblanoMohammed UniversityTarek DendaneAmine Ali ZeggwaghHicham BalkhiMina ElkhayariNacer SamkaouiHanane EzzouineAbdellatif BenslamaMourad AmorWajdi MaazouziNedim CimicOliver BeckMonique BrunsJeroen SchoutenMyra RiniaMonique RaaijmakersLeo HeunksHellen van WezelSerge HeinesUlrich StrauchMarc BuiseFabienne SimonisMarcus SchultzJennifer GoodsonTroy BrowneLeanlove NavarraAnna HuntRobyn HutchisonMathew BaileyLynette NewbyColin McarthurMichael KalkoffAlex McleodJonathan CasementDanielle HackingFinn AndersenMerete DolvaJon LaakeAndreas Barratt-DueKim Andre L. NoremarkEldar SøreideBrit Å. SjøbøAnne GuttormsenHector YoshidoRonald Zumaran AguilarFredy OscanoaAlain AlisasisJoanne RoblesRossini Abbie B. Pasanting-LimBeatriz TanPawel AndruszkiewiczKarina JakubowskaCristina CoxoAntónio AlvarezBruno OliveiraGustavo MontanhaNelson BarrosCarlos PereiraAntónio MessiasJorge MonteiroAna AraujoNuno CatorzeSusan MarumMaria BouwRui GomesVania BritoSilvia CastroJoana EstilitaFilipa BarrosIsabel SerraAurelia MartinhoDana TomescuAlexandra MarcuOvidiu BedreagMarius PapuricaDan CorneciSilvius Ioan NegoitaEvgeny GrigorievAlexey GritsanAndrey GazenkampfGhaleb AlmekhlafiMohamad AlbarrakGhanem MustafaKhalid MaghrabiNawal SalahuddinTharwat AisaAhmed Al JabbaryEdgardo TabhanYaseen ArabiOlivia TrinidadHasan Al DorziEdgardo TabhanStefan BolonOliver SmithJordi ManceboHernan Aguirre-BermeoJuan Lopez-DelgadoFrancisco EsteveGemma RialpCatalina FortezaCandelaria de HaroAntonio ArtigasGuillermo AlbaicetaSara de Cima-IglesiasLeticia Seoane-QuirogaAlexandra Ceniceros-BarrosAntonio Ruiz-AguilarLuis Claraco-VegaJuan Alfonso SolerMaria del Carmen LorenteCecilia HermosaFederico GordoMiryam Prieto-GonzálezJuan López-MessaManuel PerezCesar PerezRaquel Montoiro AllueFerran Roche-CampoMarcos Ibañez-SantacruzSusana TempranoMaria PintadoRaul de PabloPilar Ricart Aroa GómezSilvia Rodriguez RuizSilvia Iglesias MolesMª Teresa JuradoAlfons ArizmendiEnrique PiacentiniNieves FrancoTeresa HonrubiaMeisy Perez ChengElena Perez LosadaJavier BlancoLuis YusteCecilia Carbayo-GorrizFrancisca Cazorla-BarranqueroJavier AlonsoRosa AldaÁngela AlgabaGonzalo NavarroEnrique CereijoEsther Diaz-RodriguezDiego Pastor MarcosLaura Alvarez MonteroLuis Herrera ParaRoberto Jimenez SanchezMiguel Angel Blasco NavalpotroRicardo Diaz AbadRaquel Montiel Gonz Á LezDácil Parrilla ToribioAlejandro CastroMaria Jose D. ArtigaOscar PenuelasTomas RoserMoreno OlgaElena Gallego CurtoRocío Manzano SánchezVallverdu ImmaGarcia ElisabetLaura ClaveriasMonica MagretAna PellicerLucia RodriguezJesús Sánchez-BallesterosÁngela González-SalamancaAntonio JimenezFrancisco HuertaJuan Carlos J. Sotillo DiazEsther Bermejo LopezDavid MoyaAlec AlfonsoPalazon Sanchez Eugenio LuisPalazon Sanchez CesarSánchez RafaelCorcoles VirgilioNoelia RecioRichard AdamssonChristian RylanderBernhard HolzgraefeLars BromanJoanna WessberghLinnea PerssonFredrik SchiölerHans KedelvAnna Oscarsson TibblinHenrik AppelbergLars HedlundJohan HellebergKarin ErikssonRita GlietschNiklas LarssonIngela NygrenSilvia NunesAnna-Karin MorinThomas KanderAnne AdolfssonLise PiquilloudHervé ZenderCorinne Leemann-RefondiniSouheil ElatrousSlaheddine BouchouchaImed ChoucheneIslem OuanesLa MarsaAsma Ben SouissiSalma KamounOktay DemirkiranMustafa AkerEmre ErbabacanIlkay CeylanNermin Kelebek GirginMenekse OzcelikNecmettin ÜnalBasak Ceyda MecoOnat AkyolSuleyman DermanBarry KennedyKen ParharLatha SrinivasaLia McnameeDanny McauleyPhil HopkinsClare MellisVivek KakarDan HadfieldAndre VercueilKaushik BhowmickSally HumphreysAndrew FergusonRaymond MckeeAshok RajDanielle FawkesPhilip WattLinda TwoheyRajeev ThomasAlex MortonVarsha KadabaMark SmithAnil HormisSanthana KannanMiriam NamihHenrik ReschreiterJulie CamsooksaiAlek KumarSzabolcs RugonfalviChristopher NuttOrla OneillColette SeasmanGed DempseyChristopher ScottHelen EllisStuart MckechniePaula HuttonNora Di TomassoMichela VitaleRuth GriffinMichael DeanJulius CranshawEmma WillettNicholas IoannouSarah GillisPeter CsabiRosaleen MacfadyenHeidi DawsonPieter PreezAlexandra WilliamsOwen BoydLaura Ortiz-Ruiz de GordoaJon BramallSophie SymmondsSimon ChauTim WenhamTamas SzakmanyPiroska Toth-TarsolyKatie MccalmanPeter AlexanderLorraine StephensonThomas CollyerRhiannon ChapmanRaphael CooperRussell AllanMalcolm SimDavid WrathallDonald IrvineKim ZantuaJohn AdamsAndrew BurtenshawGareth SellorsIngeborg WeltersKaren WilliamsRobert HessellMatthew OldroydCeri BattleSuresh PillaiIstvan KajtorMageswaran SivashanmugavelSinead OkaneAdrian DonnellyAniko FrigyikJon CarelessMartin MayRichard StewartT. John TrinderSamantha HaganMatt WiseJade ColeCaroline MacfieAnna DowlingJavier HurtadoNicolás NinJavier HurtadoEdgardo NuñezGustavo PittiniRuben RodriguezMaría ImperioCristina SantosAlberto DeicasCarolina SerraAditya UppalapatiGhassan KamelValerie Banner-GoodspeedJeremy BeitlerSatyanarayana Reddy MukkeraShreedhar KulkarniJarone LeeTomaz MesarJohn Shinn IiiDina GomaaChristopher TainterJarone LeeTomaz MesarJarone LeeDale YeattsJessica WarrenMichael LanspaRussel MillerColin GrissomSamuel BrownPhilippe BauerRyan GosselinBarrett KitchJason CohenScott BeegleRenaud GueretAiman TulaimatShazia ChoudryWilliam StiglerHitesh BatraNidhi HuffKeith LambTrevor OettingNicholas MohrClaine JudyShigeki SaitoFayez KheirFayez KheirAdam SchlichtingAngela DelsingDaniel CrouchMary ElmasriDaniel CrouchDina IsmailKyle DreyerThomas BlakemanKyle DreyerDina GomaaRebecca BaronCarolina Quintana GrijalbaPeter HouRaghu SeethalaImo AisikuGalen HendersonGyorgy FrendlSen-Kuang HouRobert OwensAshley SchomerVesna BumbasirevicBojan JovanovicMaja SurbatovicMilic VeljovicJohn LaffeyGiacomo BellaniAntonio Pesenti
• Organismes : Ospedale Multimedica Sesto San Giovanni National University of Ireland [Galway] Università degli Studi di Milano-Bicocca = University of Milano-Bicocca San Gerardo Hospital Company Monza Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Faculté de Médecine Paris-Saclay National University of Ireland [Galway] Università degli Studi di Milano-Bicocca = University of Milano-Bicocca San Gerardo Hospital Company Monza Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Critical Care le 31/10/2020

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Résumé : Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Method The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073.

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Fichiers liés : s13054-021-03465-0.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Elisabeth Le Glassvan Thuan HoangCéline BoschiLaetitia NinoveChristine ZandottiAurélie BoutinValérie BremondGrégory DubourgStephane RanqueJean-Christophe LagierMatthieu MillionPierre-Edouard FournierMichel DrancourtPhilippe GautretPhilippe Colson
• Organismes : Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections
• Publié dans Viruses le 01/11/2020

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Résumé : Background: We aimed to compare the clinical severity in patients who were coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and rhinovirus or monoinfected with a single one of these viruses. Methods: The study period ranged from 1 March 2020 to 28 February 2021 (one year). SARS-CoV-2 and other respiratory viruses were identified by real-time reverse-transcription-PCR as part of the routine work at Marseille University hospitals. Bacterial and fungal infections were detected by standard methods. Clinical data were retrospectively collected from medical files. This study was approved by the ethical committee of our institute. Results: A total of 6034/15,157 (40%) tested patients were positive for at least one respiratory virus. Ninety-three (4.3%) SARS-CoV-2-infected patients were coinfected with another respiratory virus, with rhinovirus being the most frequent (62/93, 67%). Patients coinfected with SARS-CoV-2 and rhinovirus were significantly more likely to report a cough than those with SARS-CoV-2 monoinfection (62% vs. 31%; p = 0.0008). In addition, they were also significantly more likely to report dyspnea than patients with rhinovirus monoinfection (45% vs. 36%; p = 0.02). They were also more likely to be transferred to an intensive care unit and to die than patients with rhinovirus monoinfection (16% vs. 5% and 7% vs. 2%, respectively) but these differences were not statistically significant. Conclusions: A close surveillance and investigation of the co-incidence and interactions of SARS-CoV-2 and other respiratory viruses is needed. The possible higher risk of increased clinical severity in SARS-CoV-2-positive patients coinfected with rhinovirus warrants further large scale studies.

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Fichiers liés : viruses-13-02528.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Yue JiaoFabienne LesueurChloé-Agathe AzencottMaïté LaurentNoura MebiroukLilian LabordeJuana BeauvalletMarie-Gabrielle DondonSéverine Eon-MarchaisAnthony LaugéNadia Boutry-KryzaAlain CalenderSophie GiraudMélanie LéoneBrigitte Bressac-De-PailleretsOlivier CaronMarine Guillaud-BatailleYves-Jean BignonNancy UhrhammerValérie BonadonaChristine LassetPascaline BerthetLaurent CasteraDominique VaurViolaine BourdonCatherine NoguèsTetsuro NoguchiCornel PopoviciAudrey RemenierasHagay SobolIsabelle CoupierPierre-Olivier HarmandPascal PujolPaul VilquinAurélie DumontFrançoise RévillionDanièle MullerEmmanuelle Barouk-SimonetFrançoise BonnetVirginie BubienMichel LongyNicolas SévenetLaurence GladieffRosine GuimbaudViviane FeillelChristine ToulasHélène DreyfusDominique LerouxMagalie PeysselonChristine RebischungAmandine BaurandGeoffrey BertoloneFanny CoronLaurence FaivreVincent GoussotCaroline JacquotCaroline SawkaCaroline KientzMarine LebrunFabienne PrieurSandra Fert-FerrerVéronique MariLaurence Vénat-BouvetStéphane BézieauCapucine DelnatteIsabelle MortemousqueFlorence CouletFlorent SoubrierMathilde WarcoinMyriam BronnerSarab LizardJohanna SokolowskaMarie-Agnès Collonge-RameAlexandre DamettePaul GestaHakima LallaouiJean ChiesaDenise Molina-GomesOlivier IngsterSylvie Manouvrier-HanuSophie LejeuneCatherine NoguèsLilian LabordePauline PontoisDominique Stoppa-LyonnetMarion Gauthier-VillarsBruno BuecherOlivier CaronEmmanuelle Mouret-FourmeJean-Pierre FrickerChristine LassetValérie BonadonaPascaline BerthetLaurence FaivreElisabeth LuporsiMarc FrénayLaurence GladieffPaul GestaHagay SobolFrançois EisingerJessica MorettaMichel LongyCatherine DugastChrystelle ColasFlorent SoubrierIsabelle CoupierPascal PujolAlain LortholaryPhilippe VenninClaude AdenisTan Dat NguyenCapucine DelnatteAnnick RossiJulie TinatIsabelle TennevetJean-Marc LimacherChristine MaugardYves-Jean BignonLiliane DemangeHélène DreyfusOdile Cohen-HaguenauerBrigitte Gilbert-DussardierDominique LerouxHélène Zattara-CannoniCatherine NoguèsNadine AndrieuDominique Stoppa-LyonnetSandrine Caputo
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans BMC Medical Research Methodology le 01/11/2020

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Résumé : Abstract Background Linking independent sources of data describing the same individuals enable innovative epidemiological and health studies but require a robust record linkage approach. We describe a hybrid record linkage process to link databases from two independent ongoing French national studies, GEMO (Genetic Modifiers of BRCA1 and BRCA2 ), which focuses on the identification of genetic factors modifying cancer risk of BRCA1 and BRCA2 mutation carriers, and GENEPSO (prospective cohort of BRCAx mutation carriers), which focuses on environmental and lifestyle risk factors. Methods To identify as many as possible of the individuals participating in the two studies but not registered by a shared identifier, we combined probabilistic record linkage (PRL) and supervised machine learning (ML). This approach (named “PRL + ML”) combined together the candidate matches identified by both approaches. We built the ML model using the gold standard on a first version of the two databases as a training dataset. This gold standard was obtained from PRL-derived matches verified by an exhaustive manual review. Results The Random Forest (RF) algorithm showed a highest recall (0.985) among six widely used ML algorithms: RF, Bagged trees, AdaBoost, Support Vector Machine, Neural Network. Therefore, RF was selected to build the ML model since our goal was to identify the maximum number of true matches. Our combined linkage PRL + ML showed a higher recall (range 0.988–0.992) than either PRL (range 0.916–0.991) or ML (0.981) alone. It identified 1995 individuals participating in both GEMO (6375 participants) and GENEPSO (4925 participants). Conclusions Our hybrid linkage process represents an efficient tool for linking GEMO and GENEPSO. It may be generalizable to other epidemiological studies involving other databases and registries.

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• Type de publi. :
• Date de publi. : 01/12/2021
• Auteurs : Julien Gomez-MartinezVincent FoulongneDidier LaureillardNicolas NagotBrigitte MontèsJean-François CantaloubePhilippe van de PerreChantal Fournier-WirthJean-Pierre MolèsJean-Charles Brès
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Clémence MaraisCaroline ClaudeNada SemaanRamy CharbelSimon BarreaultBrendan TravertJean-Eudes PiloquetZoé DemaillyLuc MorinZied MerchaouiJean-Louis TeboulPhilippe DurandJordi MiatelloPierre TissièresSimon BarreaultMélissa BeggazRamy CharbelCaroline ClaudeZoé DemaillyPhilippe DurandGaspard GerschenfeldJessica GiraldiMatteo GuerraManon HilyMartin JournauxChristopher LaiPauline LerouxClémence MaraisZied MerchaouiJordi MiatelloClarisse NiçaiseJean-Eudes PiloquetMelissa RenMarie SimbozelNada SemaanJean-Louis TeboulPierre TissieresBrendan Travert
• Organismes : Assistance publique - Hôpitaux de Paris (AP-HP)
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim of this study is to review phenotypic characteristics of myeloid cells and evaluate their relations with the occurrence of secondary infection and mortality in patients with COVID-19 admitted in an intensive care unit. Methods Retrospective analysis of the circulating myeloid cells phenotypes of adult COVID-19 critically ill patients. Phenotyping circulating immune cells was performed by flow cytometry daily for routine analysis and twice weekly for lymphocytes and monocytes subpopulations analysis, as well as monocyte human leukocyte antigen (mHLA)-DR expression. Results Out of the 29 critically ill adult patients with severe COVID-19 analyzed, 12 (41.4%) developed secondary infection and six patients died during their stay. Monocyte HLA-DR kinetics was significantly different between patients developing secondary infection and those without, respectively, at day 5–7 and 8–10 following admission. The monocytes myeloid-derived suppressor cells to total monocytes ratio was associated with 28- and 60-day mortality. Those myeloid characteristics suggest three phenotypes: hyperactivated monocyte/macrophage is significantly associated with mortality, whereas persistent immunodepression is associated with secondary infection occurrence compared to transient immunodepression. Conclusions Myeloid phenotypes of critically ill COVID-19 patients may be associated with development of secondary infection, 28- and 60-day mortality.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Maeva RodriguezStéphanie RagotRémi CoudroyJean-Pierre QuenotPhilippe VignonJean-Marie ForelAlexandre DemouleJean-Paul MiraJean-Damien RicardSaad NseirGwenhael ColinBertrand PonsPierre-Eric DaninJérome DevaquetGwenael PratHamid MerdjiFranck PetitpasEmmanuel VivierArmand Mekontso-DessapMai-Anh NayPierre AsfarJean DellamonicaLaurent ArgaudStephan EhrmannMuriel FartoukhChristophe GiraultNancy Kentish-BarnesArnaud W. ThilleJean-Pierre FratDelphine ChatellierFlorence BoissierAnne VeinsteinClaire Dahyot-FizelierAuguste DargentAudrey LargeEmmanuelle BegotClaire ManciaMaxence DecaveleMartin DresSamuel LehingueLaurent PapazianMarine PaulNathalie MarinMatthieu Le MeurMohammed LaissyAnahita RouzéMatthieu Henry-LagarrigueAihem YehiaFrédéric MartinoCharles CerfPierre BaillyJulie HelmsJean Baptiste PutegnatKeyvan RazaziThierry BoulainSéverin CabassonFlorent WalletKada KloucheFrédéric Bellec
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Service de Médecine Intensive et Réanimation [Strasbourg] Nanomédecine Régénérative Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402)
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity. Methods Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m −2 ) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO 2 /FiO 2 < 300 mm Hg). The primary outcome was the occurrence of severe hypoxemia (pulse oximetry < 80%) during the intubation procedure. Results Among the 313 patients included in the original trial, 91 (29%) had obesity with a mean body mass index of 35 ± 5 kg·m −2 . Patients with obesity were more likely to experience an episode of severe hypoxemia during intubation procedure than patients without obesity: 34% (31/91) vs. 22% (49/222); difference, 12%; 95% CI 1 to 23%; P = 0.03. Among patients with obesity, 40 received preoxygenation with noninvasive ventilation and 51 with high-flow nasal oxygen. Severe hypoxemia occurred in 15 patients (37%) with noninvasive ventilation and 16 patients (31%) with high-flow nasal oxygen (difference, 6%; 95% CI − 13 to 25%; P = 0.54). The lowest pulse oximetry values during intubation procedure were 87% [interquartile range, 77–93] with noninvasive ventilation and 86% [78–92] with high-flow nasal oxygen ( P = 0.98). After multivariable analysis, factors independently associated with severe hypoxemia in patients with obesity were intubation difficulty scale > 5 points and respiratory primary failure as reason for admission. Conclusions Patients with obesity and acute hypoxemic respiratory failure had an increased risk of severe hypoxemia during intubation procedure as compared to patients without obesity. However, preoxygenation with noninvasive ventilation may not reduce this risk compared with high-flow nasal oxygen. Trial registration Clinical trial number: NCT02668458 ( http://www.clinicaltrials.gov )

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Alexandre IngelsSophie DucKarim BensalahPierre BigotPhilippe PaparelJean-Baptiste BeauvalLaurent SalomonAlexandre de La TailleHervé LangFrançois-Xavier NouhaudJosé Batista da CostaCharles DarianeHervé BaumertMorgan RoupretThibaut WaeckelCédric LebacleJean-Alexandre LongFrançois HenonJean-Jacques PatardNicolas DoumercArnaud MejeanMarie-Neige VideauJean-Christophe Bernhard
• Organismes : CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Lyon Sud [CHU - HCL] Clinique La Croix du Sud CHU Mont de Marsan CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire [Strasbourg] CHU Rouen CHU Henri Mondor [Créteil] Hôpital Européen Georges Pompidou [APHP] Centre hospitalier Saint-Joseph [Paris] CHU Pitié-Salpêtrière [AP-HP] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Mont de Marsan Centre Hospitalier Universitaire de Toulouse Centre hospitalier Saint-Joseph [Paris] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux
• Publié dans Scientific Reports le 26/10/2020

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Résumé : To describe clinical outcomes of patients aged 75 years and above after partial nephrectomy (PN), and to assess independent factors of postoperative complications. We retrospectively reviewed information from our multi-institutional database. Every patient over 75 years old who underwent a PN between 2003 and 2016 was included. Peri-operative and follow up data were collected. Multivariate logistic regression was performed to determine independent predictive factors of postoperative complications. We reviewed 191 procedures including 69 (40%) open-surgery, and 122 (60%) laparoscopic procedures, of which 105 were robot-assisted. Median follow-up was 25 months. The mean age was 78 [75–88]. The American Society of Anesthesiologist’s score was 1, 2, 3 and 4 in 10.5%, 60%, 29% and 0.5% of patients respectively. The mean tumor size was 4.6 cm. Indication of PN was elective in 122 (65%) patients and imperative in 52 patients (28%). The median length of surgery was 150(± 60) minutes, and the median estimated blood loss 200 ml. The mean glomerular filtration rate was 71.5 ml/minute preoperatively, and 62 ml/min three months after surgery. The severe complications (Clavien III-V) rate was 6.2%. On multivariate analysis, the robotic-assisted procedure was an independent protective factor of medical postoperative complications (Odds Ration (OR) = 0.31 [0.12–0.80], p = 0.01). It was adjusted for age and RENAL score, robotic-assisted surgery (OR = 0.22 [0.06–0.79], p = 0.02), and tumor size (OR = 1.13 [1.02–1.26], p = 0.01), but the patients age did not forecast surgical complications. Partial nephrectomy can be performed safely in elderly patients with an acceptable morbidity, and should be considered as a viable treatment option. Robotic assistance is an independent protective factor of postoperative complications.

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Fichiers liés : s41598-021-96676-y.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Matthieu SchmidtBertrand GuidetAlexandre DemouleMaharajah PonnaiahMuriel FartoukhLouis PuybassetAlain CombesDavid HajageAlain MercatPierre AsfarFrançois BeloncleJulien DemiselleTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauErwen L’herCécile AubronLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PréauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DesertsQuentin MathaisGwendoline RagerPierre PasquierReignier JeanSeguin AmélieGarret CharlotteCanet EmmanuelJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonnièreDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleJérôme DevaquetGuillaume TachonRichard GallotRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles-Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan BouarMessabi BoukhanzaElsa DemarestMarie-France BajoletNathanaël CharrierAudrey QuenetCécile ZylberfajnNicolas DufourBuno MégarbaneSqébastian VoicuNicolas DeyeIsabelle MalissinFrançois LegayMatthieu DebarreNicolas BarbarotPierre FillatreBertrand DelordThomas LaterradeTahar SaghiWilfried PujolPierre-Julien CungiPierre EsnaultMickael CardinaleVivien Hong Tuan HaGrégory FleuryMarie-Ange BrouDaniel ZafimahazoDavid Tran-VanPatrick AvarguesLisa CarencoNicolas RobinAlexandre OualiLucie HoudouChristophe Le TerrierNoémie SuhSteve PrimmazJérome PuginEmmanuel WeissTobias GaussJean-Denis MoyerCatherine Paugam BurtzBéatrice La CombeRolland SmonigJade ViolleauPauline CailliezJonathan ChellyAntoine MarchalotCécile SaladinChristelle BigotPierre-Marie FayolleJules FatséasAmr IbrahimDabor ResiereRabih HageClémentine CholetMarie CantierPierre TrouilerPhilippe MontraversBrice Lortat-JacobSébastien TanakaAlexy Tran DinhJacques DuranteauAnatole HarroisGuillaume DubreuilMarie WernerAnne GodierSophie HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonOlivier LangeronEric LevesqueArié AttiasCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoLea Satre-BuissonChristophe GuttonElise YvinClémence MarcaultÉlie AzoulayMichaël DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierSylvène RosseliGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozRostane GaciSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaKais MhamdiBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGaël PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereFlorent BavozetAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe Institut Pierre Louis d'Epidémiologie et de Santé Publique Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe Neurophysiologie Respiratoire Expérimentale et Clinique Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe CHU Tenon [AP-HP] Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) Laboratoire d'Imagerie Biomédicale [Paris] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Background Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID–ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19. Machine learning was used to develop dynamic, clinically useful models able to predict 90-day mortality using ICU data collected on day (D) 1, D7 or D14. Results Survival of Severely Ill COVID (SOSIC)-1, SOSIC-7, and SOSIC-14 scores were constructed with 4244, 2877, and 1349 patients, respectively, randomly assigned to development or test datasets. The three models selected 15 ICU-entry variables recorded on D1, D7, or D14. Cardiovascular, renal, and pulmonary functions on prediction D7 or D14 were among the most heavily weighted inputs for both models. For the test dataset, SOSIC-7’s area under the ROC curve was slightly higher (0.80 [0.74–0.86]) than those for SOSIC-1 (0.76 [0.71–0.81]) and SOSIC-14 (0.76 [0.68–0.83]). Similarly, SOSIC-1 and SOSIC-7 had excellent calibration curves, with similar Brier scores for the three models. Conclusion The SOSIC scores showed that entering 15 to 27 baseline and dynamic clinical parameters into an automatable XGBoost algorithm can potentially accurately predict the likely 90-day mortality post-ICU admission (sosic.shinyapps.io/shiny). Although external SOSIC-score validation is still needed, it is an additional tool to strengthen decisions about life-sustaining treatments and informing family members of likely prognosis.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : A. LaurentAlicia FournierFlorent LheureuxGuillaume LouisSaad NseirGwenaelle JacqCyril GoulenokGrégoire MullerJulio BadieBélaïd BouhemadMarjolaine GeorgesPaul-Michel MertesHamid MerdjiVincent CastelainCaroline AbdulmalakOlivier LesieurGaëtan PlantefeveJean-Claude LacheradeJean-Philippe RigaudNicholas SedillotDamien RouxNicolas TerziPascal BeuretAntoine MonselAnne-Laure PoujolKhaldoun KuteifanThierry VanderlindenAnne RenaultBérengère VivetChristophe VinsonneauSaber Davide BarbarGilles CapellierJean DellamonicaStephan EhrmannThomas RimmeléJulien BohéPierre BoujuSébastien GibotBruno LevyJohanna TemimeCyrille PichotDavid SchnellDiane FriedmanPierre AsfarEddy LebasPhilippe MateuKada KloucheJuliette AudibertFiona EcarnotNicolas Meunier-BeillardMélanie LoiseauIrène François-PursellChristine BinquetJean-Pierre Quenot
• Organismes : Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] Service d'anesthésie - réanimation chirurgicale [CHU de Dijon] Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] UFR des Sciences de Santé (Université de Bourgogne) Centre hospitalier régional de Metz-Thionville Centre Hospitalier Régional Universitaire [CHU Lille] Service de réanimation [CH Versailles] Ramsay Générale de Santé - Hôpital Privé La Louvière Centre Hospitalier Regional d'Orléans Hôpital Nord Franche-Comté [Hôpital de Trévenans] Service d'anesthésie - réanimation chirurgicale [CHU de Dijon] Service de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon] Hôpitaux Universitaires de Strasbourg Université de Strasbourg Nouvel Hôpital Civil de Strasbourg Hôpital de Hautepierre [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Chalon-sur-Saône William Morey Centre Hospitalier de La Rochelle (CHR) Service de réanimation (CH d'Argenteuil) Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Service de Médecine Intensive Réanimation (CH Dieppe) Espace de réflexion éthique de Normandie Centre Hospitalier Fleyriat [Bourg en Bresse] Service des soins intensifs [Hôpital Louis Mourier] Infection, Anti-microbiens, Modélisation, Evolution Service de Réanimation Médicale [Grenoble] Centre Hospitalier de Roanne CHU Pitié-Salpêtrière [AP-HP] Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Adaptation, mesure et évaluation en santé. Approches interdisciplinaires École de Psychologues Praticiens Groupe hospitalier de la région de Mulhouse et Sud-Alsace Groupe Hospitalier de l'Institut Catholique de Lille CHRU Brest - Département d'Anesthésie Réanimation Groupe Hospitalier de La Haute-Saône Centre Hospitalier de Béthune Unité de réanimation médicale [CHU de Carémeau, Nîmes] Centre Hospitalier Régional Universitaire de Besançon Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Centre Hospitalier Universitaire de Nice Centre Hospitalier Régional Universitaire de Tours Centre d’Investigation Clinique [Tours] CIC 1415 Centre d’Etude des Pathologies Respiratoires [Tours] Hôpital Edouard Herriot [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Groupe Hospitalier Bretagne Sud Centre Hospitalier Régional Universitaire de Nancy Défaillance Cardiovasculaire Aiguë et Chronique Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy] Centre Hospitalier de Lens Centre Hospitalier Louis Pasteur [Dole] Centre Hospitalier d'Angoulême Hôpital Raymond Poincaré [AP-HP] CHU d'Angers [Département Urgences] Centre hospitalier Bretagne Atlantique (Morbihan) Centre Hospitalier de Charleville-Mezières Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Service de Réanimation polyvalente [Chartres] Service de cardiologie [CHRU de Besançon] Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Délégation à la recherche clinique et à l'innovation [CHU Dijon] Service de médecine légale (Institut médico-légal et Unité médico-judiciaire) (CHU de Dijon) Cellule d'urgence médico-psychologique Service de médecine légale (Institut médico-légal et Unité médico-judiciaire) (CHU de Dijon) Cellule d'urgence médico-psychologique Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Service d'anesthésie - réanimation chirurgicale [CHU de Dijon] Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Espace de Réflexion Éthique Bourgogne Franche-Comté
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Background We investigated the impact of the COVID-19 crisis on mental health of professionals working in the intensive care unit (ICU) according to the intensity of the epidemic in France. Methods This cross-sectional survey was conducted in 77 French hospitals from April 22 to May 13 2020. All ICU frontline healthcare workers were eligible. The primary endpoint was the mental health, assessed using the 12-item General Health Questionnaire. Sources of stress during the crisis were assessed using the Perceived Stressors in Intensive Care Units (PS-ICU) scale. Epidemic intensity was defined as high or low for each region based on publicly available data from Santé Publique France. Effects were assessed using linear mixed models, moderation and mediation analyses. Results In total, 2643 health professionals participated; 64.36% in high-intensity zones. Professionals in areas with greater epidemic intensity were at higher risk of mental health issues ( p < 0.001), and higher levels of overall perceived stress ( p < 0.001), compared to low-intensity zones. Factors associated with higher overall perceived stress were female sex ( B = 0.13; 95% confidence interval [CI] = 0.08–0.17), having a relative at risk of COVID-19 ( B = 0.14; 95%-CI = 0.09–0.18) and working in high-intensity zones ( B = 0.11; 95%-CI = 0.02–0.20). Perceived stress mediated the impact of the crisis context on mental health ( B = 0.23, 95%-CI = 0.05, 0.41) and the impact of stress on mental health was moderated by positive thinking, b = − 0.32, 95% CI = − 0.54, − 0.11. Conclusion COVID-19 negatively impacted the mental health of ICU professionals. Professionals working in zones where the epidemic was of high intensity were significantly more affected, with higher levels of perceived stress. This study is supported by a grant from the French Ministry of Health (PHRC-COVID 2020).

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Fichiers liés : 2021 Laurent et al.,.pdf

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