Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 06/01/2026
• Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaSonakshi AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhTorsten AkessonDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoGuillaume Lucas AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeDerrick AllenJonny AllenJulia Frances AllenCamron Stephen AlleyAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlThiziri AmezzaBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioKonstantinos AxiotisAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerMarzieh BahmaniDaniel BahnerKehang BaiLuke BainesKeith BakerDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzIsaac BamwidhiElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosMarta Baselga BacarditSaleh BashiriAhmed BassalatMatthew Joseph BassoSusan BatajuRussell BateRichard BatesSouad BatlamousMarco BattagliaDaariimaa BattulgaMatteo BauceLukas BauckhagePatrick BauerLukas BayerTomas BazzanoJames BeachamTristan BeauJean Yves BeaucampPierre-Hugues BeaucheminPhilip BechtleHans Peter BeckKathrin BeckerAndrew BeddallVadim BednyakovChris BeeLars BeemsterMarcia BegalliMichael BegelJanna Katharina BehrJoshua Falco BeirerFlorian BeisiegelMohamed BelfkirGideon BellaLorenzo BellagambaAlain BelleriveCasey Dominik BellgraphPanagiotis BellosKonstantin BeloborodovIlyas BenaoumeurDriss BenchekrounFatima BendebbaYan BenhammouKees BenkendorferLydia Audrey BeresfordMatteo Mario BerettaElin Bergeaas KuutmannNicolas BergerBenedikt Ludwig BergmannJuerg BeringerGregorio BernardiCatrin BerniusFlorian Urs BernlochnerAdrian Berrocal GuardiaTracey BerryPeter BertaAnnalisa BertiRaphael BertrandSiegfried BethkeAlessandra BettiAdrian BevanLucas BezioNaman Kumar BhallaShudhashil BharthuarSomadutta BhattaPrajita BhattaraiZubair BhattiKartik Deepak BhideVallary Shashikant 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CanaleAli Can CanbayEnzo CanoneroJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasMichael Patrick CardiffGiovandomenico CarducciTancredi CarliGiampaolo CarlinoJuan Ignacio CarlottoBen CarlsonEvan Michael CarlsonLeonardo CarminatiAlberto CarnelliMaria CarnesaleSascha CaronEdson Carquin LopezIsabel Beth CarrSonia CarraGiuseppe CarrattaClara Carrion MartinezAnthony Maurel CarrollPilar Casado LechugaPierluigi CasolaroMaximilian CasparWhitmaur Robert CastiglioniFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreTom CavaliereViviana CavaliereLaura Juliana Caviedes BetancourtEmre CelebiSofia CellaVilius CepaitisKarel CernyAugusto Santiago CerqueiraAlessandro CerriLucio CerritoFabio CeruttiBeatrice CervatoAlberto CervelliGianmario CesariniSerkant CetinPaul Mickael ChabrillatRagansu ChakkappaiSnigdho ChakrabortyAidan ChambersJay ChanWai Yuen ChanJohn Derek 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ConnellSimon ConnellEimear Isobel ConroyMichelle Contreras CossioFrancesco ConventiAmanda SarkarLorenzo CorazzinaFederico Andrea CorchiaArtur Cordeiro Oudot ChoiLouie Dartmoor CorpeMassimo CorradiFrancois CorriveauArely Cortes-GonzalezMaria Jose Costa MezquitaFrancesco CostanzaDavide CostanzoJeremy CouthuresGlen CowanKyle Stuart CranmerLucas CremerDavide CremoniniSabine Chrystel Crepe-RenaudinFrancesco CrescioliTommaso CrestaMarkus CristinzianiMarco CristoforettiEdoardo CritelliAna Rosario Cueto GomezHanfei CuiMaxwell CuiBetsy CunnettLiam CunninghamFrancesco CurcioJennifer Rachel CurranMario SousaJoao Victor da Fonseca PintoCinzia da ViaWladyslaw DabrowskiTomas DadoSalah-Eddine DahbiTiesheng DaiDaniele Dal SantoCarlo DallapiccolaMogens DamGabriele d'AmenValerio d'AmicoJeff DandoyMichele d'AndreaDominik DannheimGabriele d'AnniballeMatthias DanningerValerio DaoNanni DarboSruthy Jyothi DasFilippo DattolaSaverio d'AuriaAntonio d'AvanzoTomas DavidekJoel DavidsonIan DawsonKaushik DeCarolina de Almeida RossiRiccardo de AsmundisNicola de BiaseStefano de CastroNicolo de GrootPaul de JongHector de la Torre PerezAntonio de MariaAlessandro de SalvoUmberto de SanctisFrancesco de SantisAntonella de SantoJean-Baptiste de Vivie de RegieJernej DebevcDmitri DedovichJordy DegensAllison Mccarn DeianaJose del PesoLine DelagrangeFrederic DeliotChris Malena DelitzschMassimo Della PietraDomenico Della VolpeAndrea Dell'AcquaLidia Dell'AstaMarco DelmastroClaudia Caterina DeloguPierre Antoine DelsartSarah Marie DemersMikhail DemichevSerguei DenisovHaluk DenizliMehul Gunvant DepalaLouis D'EramoDominik Karol DerendarzFrederic DeruePaul DervanAman Mukeshbhai DesaiKlaus DeschFrancesco Armando Di BelloAnna Di CiaccioLucia Di CiaccioCamilla Di DonatoAlessandro Di GirolamoGiulia Di GregorioAndrea Di LucaBiagio Di MiccoRoberto Di NardoKarri Folan Di PetrilloMagda DiamantopoulouFlavia de Almeida DiasMarco Aurelio Diaz GutierrezAlisa Romanovna DidenkoMariia DidenkoSascha Daniel DiefenbacherEdward DiehlSergio Diez CornellCarmen Diez PardosChristina DimitriadiAleksandra DimitrievskaAman DimriYuexin DingJochen Christian DingfelderThomas Benjamin DingleyIoan-Mihail DinuSebastian DittmeierFido DittusMartin DivisekBhupesh DixitFares DjamaTamar DjobavaCaterina DoglioniAdriana DohnalovaZdenek DolezalKarolina DomijanKristin DonaMarisilvia DonadelliBinbin DongJulien Noce DoniniAdelina d'OnofrioMonica d'OnofrioJens DopkeAlessandra DoriaNuno dos Santos FernandesIgo Amauri dos Santos LuzPatrick DouganMaria Teresa DovaTony DoyleMatthias Peter DrescherEtienne DreyerIoannis Drivas-KoulourisMatthew DrnevichDongshuo DuTristan Arnoldus Du PreeZonghuan DuanMathis DubauFilipp DubininMichal DubovskyEhud DuchovniGuenter DuckeckPhilippa Kathryn DuckettOtilia Anamaria DucuDominik DudaAlexey DudarevMaria Malgorzata DudekEmily Rose DudenMatteo d'UffiziLaurent DuflotMichael Duehrssen-DeblingIoana DuminicaAna Elena DumitriuMonica DunfordArnaud DuperrinHatice YildizArchil DurglishviliIan DyckesMateusz DyndalBartosz Sebastian DziedzicZoe Olivia EarnshawGregor Hieronymus EberweinBarbora EckerovaStephen EggebrechtEdmar Egidio Purcino de SouzaGerald EigenKevin Frank EinsweilerTord EkelofPer Alexander EkmanSaad El FarkhYassine El GhazaliHassnae El JarrariAli El MoussaouyIdo ElbazDoga ElitezMattias EllertFrank EllinghausTom ElliotJohannes ElmsheuserMai ElsawyMarkus ElsingDmitry EmeliyanovYuji EnariShalini EpariDaniel Ernani Martins NetoFlorian ErnstMarc EscalierCarlos Escobar IbanezRodrigo Estevam de PaulaErez EtzionGuiomar Gaspar de Andrade EvansHal EvansLevi EvansAleksei EzhilovSanae EzzarqtouniFederica FabbriLaura FabbriGabriel FaciniVitaliy FadeyevRinat FakhrutdinovDionysios FakoudisSperanza FalcianoLuis Falda CoelhoFrancesco FallavollitaGregorio FalsettiJana FaltovaCunwei FanKa Yan FanYunyun FanYaquan FangMarcello FantiMohammed FarajZahra FarazpayAmir FarbinAda FarillaKiran FarmanJesse FarrMichael Steven FarringtonSinead FarringtonFarida FassiDimitris FassouliotisLouis FayardPavol FedericPavla FedericovaOleg FedinMatthew FeickertLorenzo FeligioniDeion Elgin FellersCunfeng FengYuan FengZhuoran FengBeltran Fernandez BarbadilloPablo Fernandez MartinezMaxime FernouxJames FerrandoArnaud FerrariPamela FerrariRoberto FerrariDidier FerrereClaudio FerrettiMatthew FewellDavide FiaccoFrank FiedlerPetr FiedlerSergey FilimonovMatei Stefan FilipAndrej FilipcicEmily FilmerFrank FilthautMiguel Castro Nunes FiolhaisLuca FioriniWade Cameron FisherTobias FitschenPeter Michael FitzhughIvor FleckPhilipp FleischmannTobias FlickMarvin FloresLuis Roberto Flores CastilloMartin FollFrancesco Maria FollegaNikolai FominJoel Hengwei FooAndrea FormicaAlessandra FortiEtienne Marie FortinAnne Winifred FortmanLiam FosterLeonidas FountasHarald FoxPaolo FrancavillaSimone FrancescatoStefano FranchellucciMatteo FranchiniSilvia FranchinoDavid FrancisLuca FrancoLaura FranconiMelissa FranklinGuglielmo FrattariYuval Yitzhak FridJohnny FriendNick FritzscheAlexander FrochDaniel FroidevauxJames FrostYao FuSebastian Julio Fuenzalida GarridoMinori FujimotoKin Yip FungEduardo Furtado De Simas FilhoMarin FurukawaMax Fuste CostaJuan Fuster VerduAnne GaaAlessandro GabrielliAndrea GabrielliPhilipp GadowGuido GagliardiLouis-Guillaume GagnonSafa GaidSean GalantzanJames GallagherElizabeth GallasAxel GallenBruce Joseph GallopKock Kiam GanYanyan GaoZhanxiang GaoAli GarabagluFrancisca Garay WallsCarmen GarciaAndrea Garcia AlonsoArianna Gemma Garcia CaffaroJose Enrique Garcia NavarroMiguel Angel Garcia RuizMaurice Garcia-SciveresGwen Llewellyn GardnerRobert William GardnerNicoletta GarelliRocky Bala GargJack GarganChristopher Andrew GarnerCameron Michael GarveyVeritas Katharina GassmannGabriella GaudioViveka GautamJan GavranovicIgor GavrilenkoAlexander GavriliukColin Warren GayGoetz GayckenAlex GekowClaudia GemmeMarie-Helene GenestAndrew Donald GentrySimon GeorgeTheodoros GeralisAchmad Aditya GerwinPaul Gessinger-BefurtMohammed GhaniKeanu GhorbanianArpan GhosalAishik GhoshAnindya GhoshBenedetto GiacobbeStefano GiaguAntonio GianniniStephen GibsonDamian GilAlexander Kevin GilbertBenjamin Jacob GilbertDag GillbergGeoffrey GillesDoug GingrichMapo GiordaniPierre-Francois GiraudGilberto GiugliarelliDanilo GiugniFrancesco GiuliIoannis GkialasLeonid GladilinClaudia GlasmanMarianna GlazewskaRiley Matthew GleasonGediminas GlemzaMarija GlisicIvan GnesiYeonju GoMaximilian Emanuel Goblirsch-KolbBenedikt GockeDominique GodinBerare GokturkSteven GoldfarbTobias GollingMpho Gift Doctor GololoAlex GolubDmitry GolubkovJason Peter GombasAgostinho da Silva GomesGabriel GomesAntonio Jesus Gomez DelegidoRicardo Jose Morais Silva GoncaloAlexi GongadzeFrancesco GonnellaJulia Lynne GonskiRichards GonzalezSantiago Gonzalez de la HozMarcus Vinicius Gonzalez RodriguesRebeca Gonzalez SuarezSergio Gonzalez SevillaLuc GoossensBenedetto GoriniEdoardo GoriniAndrej GorisekThomas Christopher GosartAl GoshawMikhail GostkinSoumyananda GoswamiCarlo Alberto GottardoStefanie Andrea GotzMohamed GouighriAnna GoussiouNicolin GovenderRadoslaw Piotr GrabarczykIwona Grabowska-BoldKevin Robert GrahamEirik GramstadSergio GrancagnoloCharles Michael GrantPaul GravilaFrancesco Giuseppe GraviliHeather GrayMatteo GrecoMatthew James GreenChristian GrefeAurora Singstad GrefsrudIngrid GregorKevin Thomas GreifPhilippe GrenierSimon Gabriel GreweTschann Grimm Kath GrimmSebastian GrinsteinEilam GrossJoern Grosse-KnetterLuke Hayden GrossmanLiang GuanGiovanni GuerrieriRuben GuevaraRalf GugelJem Aizen Mendiola GuhitAlessandro GuidaEva GuillotonStefan GuindonFangyi GuoJun GuoLinghua GuoLei GuoYuxiang GuoYuhan GuoAnubhav GuptaRajat GuptaShubham GuptaSaime GurbuzSimran Sunil GurdasaniGiuliano GustavinoPhillip GutierrezLuis Felipe Gutierrez ZagazetaManuel GutscheChristian GutschowClaire GwenlanCarl GwilliamEven Simonsen HaalandAndrew HaasMartin HabedankCarl HaberHaleh HadavandAbdelhamid HaddadAsma HadefAlina HaganJan Joachim HahnMahsana HaleemJoseph HaleyGregory HallewellJohn Andrew HallfordKenji HamanoHassane HamdaouiMatthias HamerSalah El Dine HammoudEmily HampshireLiangliang HanLiang HanShuo HanKazunori HanagakiMike HanceDhanush Anil HangalHamza HanifMichael Donald HankJorgen Beck HansenPeter HansenTorsten HarenbergSiarhei HarkushaMatthew Leary HarrisYnyr HarrisJack HarrisonPaul Fraser HarrisonMax HartNicole Michelle HartmanNikolai KrugRosie HasanYoji HasegawaDaisuke HashimotoFlorian HaslbeckSohaib HassanReiner HauserMatej HaviernikChris HawkesRichard HawkingsYuichiro HayashiDaniel HaydenRobin HayesChris HaysJonathan HaysHelen HaywardMingxu HeYajun HeYi HeNathan HeatleyVincent HedbergJesse HeilmanSarah HeimTimon HeimJochen Jens HeinrichLukas Alexander HeinrichJiri HejbalMarkus HelbigAlexander HeldSimen HellesundCole Michael HellingHannah Elizabeth HerdeYesenia Hernandez JimenezLena Maria HerrmannGregor HertenRalf HertenbergerLuis HervasMoritz HespingNigel HesseyJohannes HesslerMourad HidaouiNihad HidicEwan HillTarje Solberg HillersoyStephen HillierJulia Rose HindsFlorian HinterkeuserMinoru HiroseShigeki HiroseDominic HirschbuehlTom HitchingsBojan HitiJohn David HobbsRadu HobincuNoam Tal HodAnthony HodgesMark HodgkinsonBen HodkinsonAndreas HoeckerDustyn Dean HoferJudith HoferJessica HofnerMichael HolzbockBart HommelsVid HomsakJae Jin HongTae Min HongBenjamin Henry HoobermanWalter HopkinsMatthew Caleb HoppeschYasuyuki HoriiMalin Elisabeth HorstmannSuen HouMason Ray HousengaJames William HowarthJoaquin HoyaMiroslav HrabovskyTetiana HrynovaPai-Hsien HsuShih-Chieh HsuTao HsuMiao HuQipeng HuShuhui HuangXinhui HuangYicong HuangYingjun HuangYanping HuangZuchen HuangZdenek HubacekFabian HueggingTodd Brian HuffmanMateus HufnagelCedrine Alexandra HugliMika HuhtinenSimon Kristian HuibertsRaphael Alain HulskenCharles Elliott HultquistDaniel Lewis HumphreysNazim HuseynovAlexander HussJoey HustonBenjamin HuthJohn HuthLennart HuthRachel Jordan HynemanGiuseppe IacobucciGeorge IakovidisLydia Iconomidou-FayardJames Philip IddonPaolo IengoYutaro IiyamaTomoya IizawaYoichi 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KadirMarumi KadoHarris KaganMichael KaganAbraham KahnChristian KahraToshiaki KajiEnrique Kajomovitz MustNilotpal KakatiNiraj KakotySuman KandelNikolaos KanellosNathan Jihoon KangDeepak KarEfstathios KarentzosKiran KarkiOsama KarkoutSergey KarpovZoya KarpovaVato KartvelishviliAndrey KaryukhinEirini KasimiJudith KatzySandeep KaurKentaro KawadeMayuri Prabhakar KawaleChihiro KawamotoEllis KayStergios KazakosKaterina KazakovaVassili KazaninJames Michael KeaveneyRichard KeelerGustavs KehrisJohn Stakely KellerMitch KellyJacob Julian KempsterOldrich KepkaJustin KerrBenjamin KerridgeBorut Paul KersevanLucia KeszeghovaRaees Ahmad KhanAlexander KhanovAlexey KharlamovTatyana KharlamovaMarina KholodenkoTeng Jian KhooGia KhoriauliYoussef KhoulakiYahya A.R KhwairaDoyeong KimDongwon KimYoung-Kee KimNaoki KimuraMatthew Kevin KingstonChristian KirfelFlorian KirfelJulie Hart KirkAndrei KiryuninSayuka KitaOleh KivernykMartin KlassenChristoph Thomas KleinLucas KleinMatthew Henry KleinSamuel Byrne KleinUta KleinAlexei KlimentovPeter KluitStefan KluthEmmerich KneringerTimothy Michael KnightAndrea KnueMichael KobelDmitrii KobylianskiiSimon Florian KochMartin KocianPeter KodysDaniela KockThomas KoffasOrcun KolayIro KoletsouTomas KomarekKarsten KoenekeAlbert KongTakanori KonoNikolaos KonstantinidisPantelis KontaxakisBalazs KonyaRevital KopelianskyStefan Zenon KopernyRoland KoppenhoferKrzysztof Marian KorcylKostas KordasAndreas KornSteffen KornIlya KorolkovNatalia KorotkovaBryan KortmanOliver KortnerSandra KortnerWill KosteckaMatus KostovVadim KostyukhinAnastasia KotsokechagiaAshutosh KotwalAimilianos KoulourisAthina Kourkoumeli-CharalampidiVangelis KourlitisOndrej KovandaBob KowalewskiWitold KozaneckiAnatoli KozhinViktor KramarenkoGregor KrambergerPeter KramerAttila KrasznahorkayJack KrausJohanna Wanda KrausJakub KremerNils Benedikt KrengelTom KresseLukas KretschmannJan KretzschmarPeter KriegerKarol KrizkaKevin Alexander KroeningerHubert KrohaJiri KrollIra Joseph KrollKyle Stuart KrowpmanUladzimir KruchonakHans KruegerNils Erik KrumnackMark KruseOlesia KuchinskaiaSinan KudaySusanne KuehnRoman KustersThorsten KuhlVictor KukhtinYuri KoultchitskiSerguei KuleshovJudith KullEshita Vinay KumarMukesh KumarNeelam KumariPriyanka KumariAlexander KupcoAndrey KupichOleg KuprashHisaya KurashigeLeonid KurchaninovOleksii KurdyshAnastasia KurovaMasahiro KuzeAudrey Katherine KvamJiri KvitaNicholas KyriacouMounia LaassiriCarlos Lacasta LlacerHeiko Markus LackerDidier LacourEvgueni LadyginArthur LafargeBertrand LaforgeTheodota LagouriFatima Zahra LahbabiStan LaiWei Sheng LaiInga Katarzyna LakomiecJoseph Earl LambertSabine Wedam LammersWalter LamplChristos LampoudisGeorgios LamprinoudisAlec LancasterUlrich LandgrafMurrough LandonValerie LangAndrew James LankfordFrancesco LanniChad Stephen LantzKerstin LantzschAgostino LanzaMarta Lanzac BerrocalTommaso LariDag LarsenLauren LarsonFederico Lasagni ManghiMario LassnigSean Dean LawlorRoxani LazaridouMassimo LazzaroniEric LeHieu LeElise Maria Le Boulicaut EnnisLuc Tomas Le PottierBlaz LebanFabienne LedroitTing Fung LeeLerothodi Leonard LeeuwMichel LefebvreCharles LeggettGiovanna LehmannMatthew LeighWilliam Axel LeightWaltteri LeinonenAnthony LeisosMarco Lisboa LeiteClara Elisabeth LeitgebRupert LeitnerKatharine LeneyTatjana LenzSandra LeoneChristos LeonidopoulosAlexander LeopoldJeremie Lepage-BourbonnaisRobert LesChristopher LesterMikhail LevchenkoJessica LevequeLorne LevinsonGiacomo LevriniMaciej Piotr LewickiCharles LewisDaniel LewisLucy LewittAng LiBing LiChihao LiChangqiao LiHan LiHuanguo LiHui LiHan LiHaifeng LiJialin LiLiang LiRunze LiShu LiTong LiYulong LiZhan LiZhijie LiShiyi LiangZhijun LiangMarianna LiberatoreBarbara LibertiGustavo LibotteKi LieJuan Lieber MarinHsuan-Chu LienHui-Chi LinStorm LinLars LindenRachel Elizabeth LindleyJack LindonJerry LingElliot LipelesAnna LipniackaAlison ListerJared LittleBo LiuBingxuan LiuDanning LiuDongyi LiuEric Hsien Lung LiuJesse LiuKang LiuKun LiuMinghui LiuMingyi LiuPeilian LiuQibin LiuShanjia LiuXinyan LiuYang LiuYi LiuYanlin LiuYanwen LiuZirui LiuSteve LloydEwelina Maria LobodzinskaPeter LochEesha LodhiKristin LohwasserEleonora LoiaconoJoshua David LomasIacopo LongariniRiccardo LongoAlvaro Lopez SolisNicholas Albert Lopez-CanelasNarei Lorenzo MartinezAlexander LoryMartha Alice LosadaGianna Loeschcke CentenoXinchou LouPeter LoveMiaoran LuSicong LuYun-Ju LuHenry LubattiClaudio LuciFabio Lucio Lucio AlvesFred LuehringBenji LundayOlof LundbergJenny LundeNicholas LuongoMargaret LutzAdam Brayton LuxDavid LynnRoman LysakViktoriia LysenkoElse LytkenVladimir LyubushkinTatiana LyubushkinaMars LyukovaHong MaKuo MaLianliang MaWenhao MaYanhui MaJack MacdonaldPaulo Cesar Machado de Abreu FariasDaniela MacinaRomain MadarThandikire MadulaJunpei MaedaTadashi MaenoPedro Takisa MafaHelen Ruth MaguireMinerva MaheshwariVera MaiborodaAmelia MaioKlaudia MajOliver MajerskyStephanie MajewskiRamdas MakhmanazarovNikola MakovecVeljko MaksimovicBogdan MalaescuJan 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• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Laboratoire des deux Infinis de Toulouse AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : Inclusive dijet cross-sections have been measured in proton-proton collisions at a centre-of-mass energy of 13 TeV using data with an integrated luminosity of 140 fb$^{-1}$, recorded by the ATLAS detector at the Large Hadron Collider during 2015-2018. Jets are identified using the anti-$k_{t}$ algorithm with a radius parameter of $R = 0.4$. The inclusive dijet double-differential cross-sections are measured first as a function of the invariant dijet mass and the half absolute rapidity separation between the two leading jets, $(m_{\mathrm{jj}}$, $y^{\ast})$, and second as a function of the invariant dijet mass and the total longitudinal boost of the dijet system, $(m_{\mathrm{jj}}$, $y_{\mathrm{boost}})$. The measured dijet system covers the invariant mass range from 240 GeV to almost 10 TeV, with dijet separation $y^{\ast} < 3.0$ and dijet boost $y_{\mathrm{boost}} < 3.0$. The results are unfolded to the particle level and compared with state-of-the-art next-to-next-to-leading-order full colour perturbative QCD calculations, corrected for non-perturbative and electroweak effects.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/01/2026
• Auteurs : Marine GammacurtaPascaline RedonLaurent RiquierJean-Christophe BarbeMichael JourdesAxel MarchalStéphanie Marchand-MarionAlexandre PonsGilles de RevelWarren AlbertinValérie LavigneCécile ThibonGeorgia LytraKléopatra ChiraLéa Lecomte van GelderenStéphanie PeresÉric Giraud-HeraudPierre-Louis TeissèdrePhilippe DarrietSophie Tempère
• Organismes : Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Plateforme Bordeaux Metabolome Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine Bordeaux sciences économiques Bordeaux sciences économiques Bordeaux sciences économiques Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon] Unité de Recherche Œnologie [Villenave d'Ornon]
• Publié dans OENO One le 28/10/2020

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Résumé : Bordeaux is one of the largest winegrowing regions in France, with contrasting vineyards and different terroirs. By blending several grape varieties, many styles of wine can be produced. This study investigated whether the check-all-that-apply (CATA) method can be used with a large number of wines according to their organoleptic characteristics. A wine panel assessed 143 entry-level red Bordeaux wines using 62 descriptors and a 10-point quality rating. Despite the large number of samples, the method proved repeatable and capable of discriminating wines into four groups. Twenty wines representative of the overall sampling were analysed by quantitative descriptive analysis (QDA), and the results obtained with both methods were compared. The CATA was validated for assessing a large number of samples. Selecting a representative sample of a product is essential when setting up a study in which the organoleptic diversity of the samples under evaluation may complicate their identification. The CATA method proved to be a fast, repeatable technique that allows non-trained wine experts to select a representative sample among a large number of wines.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/01/2026
• Auteurs : Sinem ÜnalStéphanie DublancHailun LiJean-Philippe VernhesVincent MeynierCamille SoudéeAchille AoubaSylvain AudiaNabil Bel FekiThierry BienvenuMartin BlondelMathieu BlotPierre CougoulAntoine DossierJean-François EmileFlorence FenollarAgnès FerroniLionel GalicierVincent GendrinAurélien GuffroyRadjiv GoulabchandAurélie JourdesJean-Christophe LagierPaul LegendreGuillaume Le GuennoTom Le VoyerGuillaume LefevreJonathan LondonAntoine NeelSébastien OttavianiRoderau OuthAilsa RobbinsAmélie ServettazMarc ScherlingerNicolas SchleinitzThibault SixtVivien BéziatGuillaume VogtXavier PuéchalJean‐laurent CasanovaJacinta BustamanteJérémie Rosain
• Organismes : Centre Hospitalier Libourne Institut de biologie physico-chimique CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Institut de psychiatrie et neurosciences de Paris Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Pôle IUCT [CHU Toulouse] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Université Paris-Saclay Assistance publique - Hôpitaux de Paris AP-HP - Hôpital Ambroise Paré Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie Risques Infectieux Tropicaux et Microorganismes Emergents Institut Hospitalier Universitaire Méditerranée Infection AP-HP - Hôpital Necker - Enfants Malades Centre Hospitalier d'Aix en Provence Centre Hospitalier Universitaire de Nice Hôpitaux Universitaires de Strasbourg Institut Desbrest d'Epidémiologie et de Santé Publique Centre Hospitalier Universitaire de Nîmes Microbes Evolution Phylogénie et Infections
• Publié dans Journal of Human Immunity le 24/10/2025

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Résumé : Tropheryma whipplei is the bacterial agent responsible for Whipple’s disease (WD). However, WD occurs only very rarely in T. whipplei-infected individuals. We investigated the cause of disease in two relatives with WD. We studied a son and his mother, both presenting an articular form of WD, at the ages of 38 and 60 years, respectively, these episodes occurring five years apart. Both were otherwise healthy. We performed whole-exome sequencing, characterized a candidate variant biochemically, and performed an immunological analysis on the patients’ leukocytes. Both patients were heterozygous for a rare missense variant of the gene encoding the transcription factor IRF4 (p.R25S), for which haploinsufficiency was previously reported to underlie WD in a large multiplex family. This variant was hypomorphic for DNA binding and transcription induction. It did not exert negative dominance. Immunity was otherwise normal in these two patients. Haploinsufficiency for IRF4 can thus underlie WD in T. whipplei–infected individuals from at least two unrelated families.

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Fichiers liés : hal-05535919.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 01/01/2026
• Auteurs : Martin SchwartzFajwel FogelNikola BesicDamien RobertLouis GeistJean-Pierre RenaudJean-Matthieu MonnetClemens MosigCédric VégaAlexandre d'AspremontLoic LandrieuPhilippe Ciais
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] CEA- Saclay Université Paris-Saclay Département d'informatique - ENS-PSL Université Gustave Eiffel IGN-France International Laboratoire d'Inventaire Forestier Ecole Nationale Supérieure de Géologie Universität Zürich [Zürich] = University of Zurich École nationale des ponts et chaussées Laboratoire d'Informatique Gaspard-Monge Université Gustave Eiffel Université de Lorraine Université Gustave Eiffel IGN-France International Laboratoire d'Inventaire Forestier Recherche, développement et innovation Laboratoire des EcoSystèmes et des Sociétés en Montagne Université Grenoble Alpes INRAE Transfert Faculty of Physics and Earth Sciences, Leipzig Institute for Meteorology, University of Leipzig Université Gustave Eiffel IGN-France International Ecole Nationale Supérieure de Géologie Laboratoire d'Inventaire Forestier Université de Lorraine Laboratoire d'informatique de l'école normale supérieure Centre National de la Recherche Scientifique Université Paris Sciences et Lettres École nationale des ponts et chaussées Laboratoire d'Informatique Gaspard-Monge Université Gustave Eiffel Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres

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Résumé : The recent decline of the European forest carbon sink highlights the need for spatially explicit and frequently updated forest monitoring tools. Yet, existing satellite-based disturbance products remain too coarse to detect changes at the scale of individual trees, typically below 100 m². Here, we introduce FORMSpoT (Forest Mapping with SPOT Time series), a decade-long (2014-2024) nationwide mapping of forest canopy height at 1.5 m resolution, together with annual disturbance polygons (FORMSpoT-Δ) covering mainland France. Canopy heights were derived from annual SPOT-6/7 composites using a hierarchical transformer model (PVTv2) trained on high-resolution airborne laser scanning (ALS) data. To enable robust change detection across heterogeneous acquisitions, we developed a dedicated post-processing pipeline combining co-registration and spatio-temporal total variation denoising. Validation against ALS revisits across 19 sites and 5,087 National Forest Inventory plots shows that FORMSpoT-Δ substantially outperforms existing disturbance products. In mountainous forests, where disturbances are small and spatially fragmented, FORMSpoT-Δ achieves an F1-score of 0.44, representing an order of magnitude higher than existing benchmarks. By enabling tree-level monitoring of forest dynamics at national scale, FORMSpoT-Δ provides a unique tool to analyze management practices, detect early signals of forest decline, and better quantify carbon losses from subtle disturbances such as thinning or selective logging. These results underscore the critical importance of sustaining very high-resolution satellite missions like SPOT and open-data initiatives such as DINAMIS for monitoring forests under climate change.

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Fichiers liés : 2512.17021v1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Nicolas BarbierPierre PlotonHadrien TuletGaëlle ViennoisHugo LeblancBenoit BurbanMaxime Réjou-MéchainPhilippe VerleyJames BallDenis FeurerGrégoire Vincent
• Organismes : Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Université de Yaoundé I = University of Yaoundé 1 Ecologie des forêts de Guyane Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Botanique et Modélisation de l'Architecture des Plantes et des Végétations
• Publié dans ISPRS Open Journal of Photogrammetry and Remote Sensing le 08/04/2024

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Résumé : This study benefited from an "Investissement d'Avenir" grant managed by the Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01), via project PHENOBS. We also acknowledge the support of the UE Biodiversa+ BiodivMon program (Project Coforfunc). We are thankful to Ilona Clocher, Jean-Louis Smock, Jean-Yves Goret, Florian Jeanne and Julien Engel for their help with drone data acquisition and/or processing. Access to the Paracou site and infrastructure (https://paracou.cirad.fr) was granted by CIRAD/Ecofog, and we thank Géraldine Derroire and all Phenobs project participants. We are grateful to Raphaël Pélissier for helping in the initial shaping of the Phenobs project and for his continued support.

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Fichiers liés : 2025.06.27.661894.full_bioarXiv.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Isabelle Sermet-GaudelusAlexia LetierceLaureline BertelootAnne-Sophie BonnelYuxin ChenPunit MakaniMairead Kelly-AubertFeriel KanounLucille PenalvaNesrine BouleghemTiphaine BihoueeStéphanie BuiHarriet CorvolVéronique HoudouinMarie MittaineAurelie TatopoulosLaurence WeissNathalie WizlaNathalie KapelAntoine BessouH TiddensDaan CaudriPhilippe ReixChristophe MarguetMarianne AlisonBaptiste ArnouatMelissande BaravalleMahassen BarbouraJeanne BarillonAudrey BarzicLilia BenhallaMyriam BenhamidaKhadidja BennourKatia BessaciAntoine BessouMarie BiardAurore BlondeBertrand BruneauAline Carsin-VuMathilde Casson-MasselinFrédérique ChedevergneCamille CisterneLaure CossonLaure CoudercCarole CouetteMarie-Laure DalphinPaola de CarliEric DeneuvilleGael DournesValerie DouzalHubert Ducou-Le-PointeClemence Dufour-BarbaRaphael EnaudMathilde FerryMorgane FlochPierre FoucaudFlaviu GaborAsma GabsiElsa GachelinCharlotte GiraudFatiha HassaniAudrey HerzogAntoine DelvalAnne HouzelFrédéric HuetAntoine HuttAhmed KhenicheMarie JaminKadiatou KabaSébastien KieferGuillaume LabbeAlice LadauradeJeanne LanguepinMuriel LauransLaurence Leclainche-VialaFaustine LefebvreThomas LefrancoisServane Lelez-SoquetMarion LenoirLouis-Marie LieberClotilde LivrozetCatthy LlerenaAlexia LetierceDamien MandrySarah MarchalChristophe MarguetSophie MayerStéphane MazurLaurent MelyRania MessaoudiBaptiste MorelCamille OhlmannJocelyne PengamStéphanie PerrezCaroline PerissonThomas PerrinIsabelle PetitPhilippe PetitJuliette PezronCarole Piccini-BaillyDelphine PouradierCinthia RamesAdelaide RegaPhilippe ReixMartine RemyNatacha RemusMarine RevillionLéa RoditisAnna RonayetteFlavie SadoneDjouher SahkiFloriane SauvageManuela ScalbertConsuelo SebastiasanchoIsabelle Sermet-GaudelusChiara SieloSophie SimonAnaëlle SimonneauFlorence SocchiNathalie StremlerAurélie TatopoulosMatthieu ThimmeschDiane Thomassonabdel-LatifGuillaume ThouveninCaroline ThumerelleCélia ThilliardJean-Yves TraversFrançoise TroussierSophie ValloisSaskia VandeperreJulie VialPhilippe VigneronMarie-Christine Werck-Gallois
• Organismes : Sorbonne Université Mucoviscidose: physiopathologie et phénogénomique [CRSA] CHU Trousseau [APHP] Centre de Recherche Saint-Antoine Hospices Civils de Lyon Hôpital Femme Mère Enfant [CHU - HCL] Centre National de la Recherche Scientifique Université Claude Bernard Lyon 1
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : ABSTRACT Background ATP‐binding cassette transporter A3 (ABCA3) deficiency is one of the most severe causes of childhood interstitial lung diseases (chILD). This study aims to report the RespiRare ABCA3 cohort and to establish phenotype‐genotype correlations. Methods Phenotypic and genotypic data of patients under 18 years were retrospectively included (1995–2023) in the RespiRare centers. The initial presentation and evolution of the subjects was analyzed depending on their genotype. Results The ABCA3 cohort comprised 36 children (30 families), including 5.5%, 22%, and 72% of null/null (no protein), null/other (potential residual function) and other/other genotypes respectively. A neonatal respiratory distress syndrome was observed in 31 (86%) subjects and 27 (75%) died at a median age of 3 months. The 5‐year overall survival was 25% with an overall median survival of 0.33 year (IQR 0.09–4.43). A neonatal onset ( p = 0.009) and the presence of pulmonary hypertension ( p = 0.037) impaired the prognosis. At the last follow‐up, the survival rates were 0/2 (0%), 4/8 (50%) and 6/26 (23%) in the null/null, null/other and other/other groups respectively. Eight of the 12 subjects who survived beyond 1 year carried at least one missense variant outside the nucleotide‐binding domains (NBD) ( n = 9) or the hypomorphic p.(Glu292Val) variant ( n = 1). Conclusion The variable presentation and outcome of chILD due to ABCA3 pathogenic variants are linked to the underlying genotype. Neonatal onset, null variants, and variants involving the NBD are of peculiar severity.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Bénédicte LelièvreCharlotte GodonPierre LegrasJeremie RiouDavid TernantJean-Philippe Bouchara
• Organismes : SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Département de Pharmacologie-Toxicologie [CHU Angers] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Micro et Nanomédecines Translationnelles Membrane Signalling and Inflammation in reperfusion Injuries Centre Hospitalier Régional Universitaire de Tours SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques
• Publié dans Biomedicine and Pharmacotherapy le 28/10/2020

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Résumé : Background: Posaconazole, a broad spectrum antifungal, may be used in salvage therapy for cerebral infections caused by Scedosporium species. In this study, its pharmacokinetics was investigated in a rat model of scedosporiosis to evaluate the effect of the infection on cerebral diffusion. Methods: Posaconazole was administered to two groups of rats randomized according to the infection status. Drug levels in plasma, cerebrospinal fluid, and brain tissue were measured up to 168 h after administration, and data were analyzed using a non-compartmental approach. In addition, interleukins (IL) (IL-1β and IL-10) were quantified by ELISA, and cerebral expression of genes encoding some efflux pumps was assessed by reverse transcription-quantitative PCR. Results: Cerebral diffusion of posaconazole and, to a lesser extent, cerebrospinal fluid exposure were significantly affected by infection. A ten-fold increase in the area under the curve and a delayed time (Tmax) to reach the maximum concentration (Cmax) were observed in the brain, along with a time lag to reach Cmax and Tmax between plasma and the brain. Infection was associated with changes in plasma pharmacokinetics, particularly at late sampling times. Conclusions: These findings suggest increased permeability of the blood-brain-barrier, possibly related to changes in IL or gene expression levels in the brain. Infection and the resulting inflammation should therefore be considered for therapeutic drug monitoring, especially in cases of cerebral infection.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Anne QuinquenelRémi LetestuMagali Le Garff-TavernierStéphane MorissetFabien SubtilThérèse AurranKamel LaribiFlorence CymbalistaVincent LévyLaurence SimonDamien Roos-WeilVéronique LeblondMarie-Sarah DilhuydyCécile TomowiakCaroline DartigeasRomain GuièzeOlivier TournilhacEmmanuelle FerrantSophie de GuibertPierre FeugierFatiha MerabetStéphane LeprêtrePhilippe CarassouJulie GayBénédicte HivertLuc-Matthieu ForneckerJehan DupuisLysiane MolinaBruno VillemagneGuillaume CartronBernard DrenouBeatrice MahéOmar BenbrahimXavier CahuChristelle PortoisLoïc YsebaertFlorence Nguyen-KhacAbdelmalek DahmaniClaire QuineyValérie RouilléAlain DelmerAnne-Sophie Michallet
• Organismes : Hôpital universitaire Robert Debré [Reims] Service d'hématologie biologique [Avicenne] AP-HP - Hôpital de la Pitié Salpêtrière Centre Léon Bérard [Lyon] Service de Biostatistiques [Lyon] Institut Paoli-Calmettes Centre Hospitalier Le Mans (CH Le Mans) AP-HP - Hôpital Avicenne AP-HP - Hôpital Avicenne Centre Hospitalier Sud Francilien - Centre Hospitalier d'Evry AP-HP - Hôpital de la Pitié Salpêtrière Sorbonne Université AP-HP - Hôpital de la Pitié Salpêtrière Sorbonne Université Service des maladies du sang Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Régional Universitaire de Tours Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier de Versailles André Mignot Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre hospitalier régional de Metz-Thionville Centre Hospitalier de la Côte Basque Groupement des Hôpitaux de l'Institut Catholique de Lille Institut de Cancérologie de Strasbourg Europe Centre Hospitalier Henri Mondor d'Aurillac CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon CHU Montpellier = Montpellier University Hospital Institut de Génétique Moléculaire de Montpellier Centre Hospitalier Emile Muller [Mulhouse] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital La Source [Orléans] Centre Hospitalier Régional d'Orléans Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Service Hématologie - IUCT-Oncopole [CHU Toulouse] AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital Avicenne AP-HP - Hôpital de la Pitié Salpêtrière CHU Montpellier = Montpellier University Hospital Hôpital universitaire Robert Debré [Reims] Centre Léon Bérard [Lyon]
• Publié dans EClinicalMedicine le 01/11/2020

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Résumé : Background: For chronic lymphocytic leukaemia (CLL) and intermediate risk factors (unmutated IGHV and/or 11q deletion and/or complex karyotype; no TP53 alteration), the best first-line treatment is unclear. We compared an MRD-guided, fixed-duration ibrutinib-venetoclax (IV) regimen to fludarabine-cyclophosphamide-rituximab (FCR) in this population. Methods: The ERADIC randomised, phase 2 trial (NCT04010968), conducted at 35 French hospitals, recruited previously untreated, fit adults with intermediate-risk CLL. Randomisation was 1:1 to: 6x4-weekly cycles of FCR (Months 1–6); or ibrutinib 420 mg/day from Month 1 plus venetoclax (ramp-up to 400 mg/day from Month 4) for a duration depending on the bone marrow measurable residual disease level at Month 9 (if undetectable at a threshold of <0·01% [BM uMRD4] to Month 15; otherwise to Month 27). Primary outcome was the BM uMRD4 rate at Month 27, by assessment oligocentrally (intent-to-treat, worst-case scenario method). Findings: Between 27 September 2019 and 31 January 2021, 120 patients were enrolled (73% male). At Month 27, the BM uMRD4 rate was 37% (22/59; 95% confidence interval [CI] 25, 51) with IV versus 13% (8/61; 95% CI 6, 24) with FCR. The high amount of missing BM MRD data, along with imbalance in missing data between arms, meant that no confirmatory statistics were performed. Best rate of BM uMRD4 plus peripheral blood uMRD5 was 47% (22/47) with IV versus 19% (8/43) with FCR (p = 0·0090). With median 43 months’ follow-up, progression-free survival was longer with IV versus FCR (estimated hazard ratio 0·35, 95% CI 0·16, 0·80, p = 0·012). By Month 27, six deaths had occurred (FCR: acute myeloid leukaemia, septic shock, myelodysplastic syndrome; IV: 2 sudden deaths, COVID-19). By the time of follow-up, the most common serious grade 3/4 events were infections and haematological toxicities with FCR, and infections and cardiovascular/metabolic toxicities with IV. Interpretation: Due to the high amount of missing BM MRD data at Month 27, the primary outcome statistical analysis was not deemed feasible. The outcomes reported are secondary and exploratory, and were not been powered for in the study design. A patient profile suitable for an MRD-guided, fixed-duration IV regimen requires consideration of potential toxicities. Funding: Abbvie and Janssen France.

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Fichiers liés : 1-s2.0-S2589537025006418-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Eric VandermolenPhilippe FerrandisFrédéric AllibertEmmanuel AugendreMassinissa NabetMartin RackJean-Pierre RaskinM. Cassé
• Organismes : Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information SOITEC Semi-conducteurs à large bande interdite SOITEC Département Composants Silicium Institute of Information and Communication Technologies, Electronics and Applied Mathematics Institute of Information and Communication Technologies, Electronics and Applied Mathematics Institute of Information and Communication Technologies, Electronics and Applied Mathematics Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
• Publié dans Solid-State Electronics le 22/10/2020

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Résumé : In this work, radio-frequency and traps properties of unintentionally doped polycrystalline silicon (polySi) deposited by low pressure chemical vapor deposition (LPCVD) on high resistivity silicon (HR-Si) substrate are characterized. Both volume (i.e. inside polySi) and interface traps (i.e. near polySi/HR-Si) are detected by photo-induced current transient spectroscopy (PICTS). A thermal budget of 900 ◦C during 2 h is sufficient to observe trap densities reduction near the polySi/HR-Si interface, affecting the RF performance of the fabricated substrates.

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Fichiers liés : Traps-and-RF-Characterization-of-Polysilicon-Layer_draft_no-T1100_final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Thibaut DevilleSelim CheaibiM. LlariWei WeiAnaïs GaroJean-Philippe LepretreP. J. ArnouxCatherine Masson
• Organismes : Laboratoire de Biomécanique Appliquée Laboratoire Mécanismes d'Accidents Laboratoire de Biomécanique Appliquée Laboratoire de Biomécanique Appliquée UTAC S.A.S, Autodrome Linas, Montlhéry, France UTAC S.A.S, Autodrome Linas, Montlhéry, France Laboratoire de Biomécanique Appliquée Laboratoire de Biomécanique Appliquée
• Publié dans Accident Analysis & Prevention le 24/10/2020

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Résumé : Powered two-wheeler (PTW) riders are vulnerable road users. Wearable airbags may help to reduce thorax injuries which are the most frequent AIS3+ injury. Nevertheless, actual tests and standard lack accident representativeness. The aim of the study was to determine realistic trunk impact conditions for representative accidents. Three accidents scenarios have been found through a literature review and their main configurations have been numerically investigated via multibody modelling. The 912 performed simulations were used to explore body contacts with counterparts over time, velocities and body orientation at contact.

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