Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Kim GénuiteJean‑jacques DelannoyJean‑jacques BahainMarceau GresseStéphane JailletAnne PhilippeEdwige Pons‑branchuAndré RevilPierre Voinchet
• Organismes : Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Histoire naturelle de l'Homme préhistorique Earthquake Research Institute [Tokyo] Environnements, Dynamiques et Territoires de Montagne Laboratoire de Mathématiques Jean Leray Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Environnements, Dynamiques et Territoires de Montagne Histoire naturelle de l'Homme préhistorique
• Publié dans Scientific Reports le 26/10/2020

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Résumé : The original version of this Article contained an error in the spelling of the author Anne Philippe, which was incorrectly given as Anne Phillippe. The original Article and accompanying Supplementary Information file have been corrected.

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Fichiers liés : s41598-021-95754-5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneGiacomo de SanctisAntonio Fernandez DumontSilvia FedericiAndrea GennaroJose Angel Gomez RuizDafni Maria KagkliAnna LanzoniFranco Maria NeriNikoletta PapadopoulouKonstantinos ParaskevopoulosTommaso Raffaello
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Maize NK603 9 T25 9 DAS-40278-9 (three-event stack maize) was produced by conventional crossing to combine three single events: NK603, T25 and DAS-40278-9. The GMO Panel previously assessed the three single maize events and two of the subcombinations and did not identify safety concerns. No new data on the single maize events or the two subcombinations were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the three-event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the three-event stack maize, as described in this application, is as safe as the non-GM comparator and the selected non-GM reference varieties. In the case of accidental release of viable grains of the three-event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in one of the maize subcombinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the three-event stack maize. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of the three-event stack maize. Post-market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the three-event stack maize and its subcombinations are as safe as the non-GM comparator and the selected non-GM reference varieties with respect to potential effects on human and animal health and the environment.

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Fichiers liés : EFSA Journal - 2021 - - Assessment of genetically modified maize NK603 T25 DAS‐40278‐9 and subcombinations for food.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Philippe RyvlinSylvain RheimsLawrence HirschArseny SokolovLara Jehi
• Organismes : Unité de Neurologie Fonctionnelle et d'Épileptologie Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Yale University [New Haven]
• Publié dans The Lancet Neurology le 27/10/2020

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Résumé : Three neuromodulation therapies have been appropriately tested and approved in refractory focal epilepsies: vagus nerve stimulation (VNS), deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS), and closed-loop responsive neurostimulation of the epileptogenic zone or zones. These therapies are primarily palliative. Only a few individuals have achieved complete freedom from seizures for more than 12 months with these therapies, whereas more than half have benefited from long-term reduction in seizure frequency of more than 50%. Implantation-related adverse events primarily include infection and pain at the implant site. Intracranial haemorrhage is a frequent adverse event for ANT-DBS and responsive neurostimulation. Other stimulation-specific side-effects are observed with VNS and ANT-DBS. Biomarkers to predict response to neuromodulation therapies are not available, and high-level evidence to aid decision making about when and for whom these therapies should be preferred over other antiepileptic treatments is scant. Future studies are thus needed to address these shortfalls in knowledge, approve other forms of neuromodulation, and develop personalised closed-loop therapies with embedded machine learning. Until then, neuromodulation could be considered for individuals with intractable seizures, ideally after the possibility of curative surgical treatment has been carefully assessed and ruled out or judged less appropriate.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Olivier LesieurJean-Pierre QuenotZoé Cohen-SolalRaphaëlle DavidLaure de Saint BlanquatMaxime ElbazBénédicte Gaillard Le RouxCyril GoulenokSylvain LavouéVirginie LemialeEmmanuelle MercierChaouki MezherBenoît MissetGwendolyn PenvenAnne-Laure PoujolBertrand QuentinRégis QuéréThierry van Der LindenJean Philippe Rigaud
• Organismes : Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hopital Saint-Louis [AP-HP] Brigade de sapeurs pompiers de Paris Hôpital Necker - Enfants Malades [AP-HP] Hôtel-Dieu Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Privé Jacques Cartier [Massy] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hopital Saint-Louis [AP-HP] Centre Hospitalier Régional Universitaire de Tours Hôpital Nord Franche-Comté [Hôpital de Trévenans] Centre Hospitalier Universitaire de Liège Hôpital universitaire Robert Debré [Reims] CHU Pitié-Salpêtrière [AP-HP] Laboratoire Interdisciplinaire d'étude du Politique Hannah Arendt Paris-Est Hôpital Necker - Enfants Malades [AP-HP] Groupement des Hôpitaux de l'Institut Catholique de Lille Centre hospitalier de Dieppe
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Intensive care unit professionals have experience in critical care and its proportionality, collegial decision-making, withholding or withdrawal of treatment deemed futile, and communication with patients' relatives. These elements rely on ethical values from which we must not deviate in a pandemic situation. The recommendations made by the Ethics Commission of the French Intensive Care Society reflect an approach of responsibility and solidarity towards our citizens regarding the potential impact of a pandemic on critical care resources in France, with the fundamental requirement of respect for human dignity and equal access to health care for all.

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Fichiers liés : s13613-021-00855-z.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Antonio GalloAntonio GalloLeopoldo Pérez de IslaSybil CharrièreAlexandre VimontRodrigo AlonsoRodrigo AlonsoOvidio Muñiz-GrijalvoJosé Díaz-DíazDaniel ZambónDaniel ZambónPhilippe MoulinPhilippe MoulinÉric BruckertEric BruckertPedro MataPedro MataSophie BéliardSophie BéliardDenis AngoulvantFranck BoccaraBertrand CariouValérie CarreauAlain CarrieSybil CharrieresYves CottinMathilde Di FilippoPierre-Henri DucluzeauSonia DulongVincent DurlachMichel FarnierEmile FerrariDorota FerrieresJean FerrieresPhilippe GiralSophie GonbertRégis HankardJocelyn InamoOlga KalmykovaMichel KrempfJulie LemaleFrançois PaillardNoel PerettiAgnes PerrinAlain PradignacJean Pierre RabesVincent RigalleauFrançois SchieleAriane SultanPatrick TounianRené ValéroBruno VergesCecile YelnikOlivier ZieglerRocío AguadoMa Pilar Álvarez-BañosRosa ArgüesoFrancisco ArrietaMiguel Ángel BarbaMarta CasañasJosé María CepedaRaimundo de AndrésGonzalo Díaz-SotoJose Luis Díaz-DiazMarta DieguezCeferino FaedoFrancisco FuentesJuan GarridoAurora GonzálezPablo González-BustosMa Dolores MañasMarta MauriJuan Diego MediavillaAlfredo MichánPablo MiramontesOvidio MuñizLeire PérezLeopoldo Perez de IslaXavier PintóManuel RomeroPatricia RubioJuan Sánchez Muñoz-TorreroJose Vidal-Pardo
• Organismes : Laboratoire de Mécanique, Modélisation et Procédés Propres Centre de Recherche Saint-Antoine Lipodystrophies, adaptations métaboliques et hormonales, et vieillissement [CRSA] Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] Pathologie Cardiovasculaire, toxicité environnementale et envenimations [UR5_3] Université des Antilles (Pôle Martinique) Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]
• Publié dans JACC: Cardiovascular Imaging le 22/10/2020

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Résumé : This study aimed at investigating the additional contribution of coronary artery calcium (CAC) score to SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study) risk equation (SAFEHEART-RE) for cardiovascular risk prediction in heterozygous familial hypercholesterolemia (HeFH).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Lingxiao HeJohn MorleyGeetika AggarwalAndrew NguyenBruno VellasPhilipe Barreto de SoutoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie Noëlle-CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean‐pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Saint Louis University Saint Louis University Saint Louis University Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Bordeaux population health Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier Equipe AGING (CERPOP)
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β = − 0.003, 95% CI [− 0.006, − 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = − 0.07, 95% CI [− 0.12, − 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.

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Fichiers liés : s41598-021-91038-0.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Yann Philippe CharlesSolène ProstSébastien PesentiBrice IharrebordeEloïse BauduinFéthi LaouissatGuillaume RiouallonStéphane WolffVincent ChallierIbrahim ObeidLouis BoissièreEmmanuelle FerreroFederico SollaJean-Charles Le HuecStéphane BourretJoe FaddoulGeorges Naïm Abi LahoudVincent FièreMichiel Vande KerckhoveMatthieu CampanaJonathan LebharHadrien GiorgiAymeric FaureEric-André SauleauBenjamin BlondelCharlie BouthorsPierre LaumonerieVincent CrennStéphane FuentesCharles CourtChristian MazelYann-Philippe CharlesFréderic SailhanPaul Bonnevialle
• Organismes : Institut des Sciences du Mouvement Etienne Jules Marey Institut des Sciences du Mouvement Etienne Jules Marey Institut des Sciences du Mouvement Etienne Jules Marey Institut des Sciences du Mouvement Etienne Jules Marey
• Publié dans European Spine Journal le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Alexandre BaudJean-Philippe JennyPierre FrancusIrene Gregory-Eaves
• Organismes : McGill University = Université McGill [Montréal, Canada] Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Eau Terre Environnement [Québec] Centre de recherche sur la dynamique du système Terre McGill University = Université McGill [Montréal, Canada]
• Publié dans Journal of Paleolimnology le 25/10/2020

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Résumé : Sediment Accumulation Rate (SAR; measured as mm yr(-1)) and Mass Accumulation Rate (MAR; measured as g cm(-2) yr(-1)) data were collected from published lake core records that spanned the past similar to 150 years, from approximately 500 sites worldwide. For each lake, key watershed characteristics including watershed size, slope, land use and climate were extracted, with the goal of quantifying the relative importance of these variables as drivers of SAR and MAR. General additive models provided evidence of accelerated global lake sediment infilling rates after AD 1950. Whereas the onset of sedimentation acceleration varied across ecoregions, global lake MAR values were found to have increased similar to threefold on average, since baseline conditions pre-1900 (i.e. mu(baseline) = 0.040 +/- 0.044 g cm(-2) yr(-1) and mu(modern) = 0.13 +/- 0.22 g cm(-2) yr(-1)). The significant drivers, identified through Linear Mixed Effect modeling of MAR time series, were watershed population density (log-transformed) and watershed cropland density (log-transformed). Our results highlight important spatial heterogeneity in SAR and MAR among lakes, precluding the use of simple modeling approaches. SAR and MAR were found to be moderately correlated to one another, despite the potential for post-depositional disparities between segments of the sediment cores. We identified organic matter content (loss-on-ignition, LOI) as a significant co-variate that could be used to correct inflated very recent SAR rates. Our empirical analyses suggest that, despite a wide range of natural variability among lakes, both SAR and MAR increased globally and the increases appear to be mainly the result of enhanced watershed activities associated with agriculture and urbanization.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Ines LakbarSophie MedamRomain RonfléNadim CassirLouis DelamarreEmmanuelle HammadAlexandre LopezAlain LepapeAnaïs MachutMohamed BoucekineLaurent ZieleskiewiczKarine BaumstarckAnne SaveyMarc LeoneSerge AlfandariSébastien BaillyOdile BajoletOlivier BaldesiAnne Berger-CarbonnePierre-Edouard BollaertCedric BretonniereCéline ChateletPhilippe CorneIsabelle Durand-JolyArnaud FriggeriGaëlle GasanRémy GauzitMarine GiardCaroline LandelleThierry LavigneDidier LepelletierPierre-François PerrigaultSantiago PicosMarie-Aline RobauxVincent StoeckelJean-François TimsitPhilippe Vanhems
• Organismes : Hôpital Nord [CHU - APHM] Service Anesthésie et Réanimation [Hôpital Nord - APHM] Aix Marseille Université Hôpital Nord [CHU - APHM] Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Centre Hospitalier Universitaire de Toulouse Service Anesthésie et Réanimation [Hôpital Nord - APHM] Assistance Publique - Hôpitaux de Marseille Centre Hospitalier Lyon Sud [CHU - HCL] Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Nord [CHU - APHM] Microbes Evolution Phylogénie et Infections
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Data on the relationship between antimicrobial resistance and mortality remain scarce, and this relationship needs to be investigated in intensive care units (ICUs). The aim of this study was to compare the ICU mortality rates between patients with ICU-acquired pneumonia due to highly antimicrobial-resistant (HAMR) bacteria and those with ICU-acquired pneumonia due to non-HAMR bacteria. We conducted a multicenter, retrospective cohort study using the French National Surveillance Network for Healthcare Associated Infection in ICUs (“REA-Raisin”) database, gathering data from 200 ICUs from January 2007 to December 2016. We assessed all adult patients who were hospitalized for at least 48 h and presented with ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii . The association between pneumonia caused by HAMR bacteria and ICU mortality was analyzed using the whole sample and using a 1:2 matched sample. Among the 18,497 patients with at least one documented case of ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii , 3081 (16.4%) had HAMR bacteria. The HAMR group was associated with increased ICU mortality (40.3% vs. 30%, odds ratio (OR) 95%, CI 1.57 [1.45–1.70], P < 0.001). This association was confirmed in the matched sample (3006 HAMR and 5640 non-HAMR, OR 95%, CI 1.39 [1.27–1.52], P < 0.001) and after adjusting for confounding factors (OR ranged from 1.34 to 1.39, all P < 0.001). Our findings suggest that ICU-acquired pneumonia due to HAMR bacteria is associated with an increased ICU mortality rate, ICU length of stay, and mechanical ventilation duration.

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Fichiers liés : 41598_2021_Article_95852.pdf

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• Type de publi. : Rapport
• Date de publi. : 30/11/2021
• Auteurs : Florence GuillotChristophe MendrygalJulien PechJeannie CadeilhanJeanne FaveroChristine BénasEva BénasPhilippe PergentPhilippe ChevalierDaniel GolDaniel GolLouis FalgayracSalomé PignonCassandra VrigneauTom SidaineArnaud GottiJacques MathieuJean-Louis EnjalbertBernard ValetteMarie-Claude ValetteAimé RejjhouJacques GriffonPierre Fevre
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés

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Fichiers liés : Rapport LBDV 2021.pdf

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