Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Anne-Marie BaconNicolas BourgonFrido WelkerEnrico CappelliniDenis FiorilloOlivier TombretNguyen Thi Mai HuongNguyen Anh TuanThongsa SayavonkhamdyViengkeo SouksavatdyPhonephanh SichanthongtipPierre-Olivier AntoinePhilippe DuringerJean-Luc PoncheKira WestawayRenaud Joannes-BoyauQuentin BoeschEric SuzzoniSébastien FrangeulElise Patole-EdoumbaAlexandra J ZachwiejaLaura ShackelfordFabrice DemeterElise DufourJean-Jacques Hublin
• Organismes : Biologie, anthropologie, biométrie, épigénétique, lignées : De la diversité des populations à l'individu, de l'identification à l'identité Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet BioArchéologie, Interactions Sociétés Environnements BioArchéologie, Interactions Sociétés Environnements Institut des Sciences de l'Evolution de Montpellier Institut de physique du globe de Strasbourg Ecole et Observatoire des sciences de la terre Laboratoire Image, Ville, Environnement Macquarie University [Sydney] Southern Cross University Institute of Vertebrate Paleontology and Paleoanthropology Ecole et Observatoire des sciences de la terre Institut de physique du globe de Strasbourg Museum d'Histoire Naturelle de La Rochelle University of Minnesota Medical School University of Illinois at Urbana-Champaign [Urbana] Section for GeoGenetics Éco-Anthropologie BioArchéologie, Interactions Sociétés Environnements Collège de France - Chaire Paléoanthropologie Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract The capability of Pleistocene hominins to successfully adapt to different types of tropical forested environments has long been debated. In order to investigate environmental changes in Southeast Asia during a critical period for the turnover of hominin species, we analysed palaeoenvironmental proxies from five late Middle to Late Pleistocene faunas. Human teeth discoveries have been reported at Duoi U’Oi, Vietnam (70–60 ka) and Nam Lot, Laos (86–72 ka). However, the use of palaeoproteomics allowed us to discard the latter, and, to date, no human remains older than ~ 70 ka are documented in the area. Our findings indicate that tropical rainforests were highly sensitive to climatic changes over that period, with significant fluctuations of the canopy forests. Locally, large-bodied faunas were resilient to these fluctuations until the cooling period of the Marine Isotope Stage 4 (MIS 4; 74–59 ka) that transformed the overall biotope. Then, under strong selective pressures, populations with new phenotypic characteristics emerged while some other species disappeared . We argue that this climate-driven shift offered new foraging opportunities for hominins in a novel rainforest environment and was most likely a key factor in the settlement and dispersal of our species during MIS 4 in SE Asia.

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Fichiers liés : Bacon et al 2021 -Scientific Reports.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Philippe JeanneretGisela LüscherManuel K SchneiderPhilippe PointereauMichaela ArndorferDebra BaileyKatalin BalázsAndrás BáldiJean-Philippe ChoisisPeter DennisMario DíazSebastian EiterZoltán ElekWendy FjellstadThomas FrankJürgen K FriedelIlse R. GeijzendorfferPippa GillinghamTiziano GomieroGergely JerkovichRob H G JongmanMax KainzAnikó Kovács-HostyánszkiGerardo MorenoJuri NascimbeneMarie-Louise OschatzMaurizio G PaolettiJean-Pierre SarthouNorman SiebrechtDaniele SommaggioSebastian WolfrumFélix Herzog
• Organismes : Agroscope Agroscope University of Applied Science Schmalkalden Association Solagro Arche Noah University Natural Resources and Life Agroscope Department of Radiation Medicine MTA Centre for Ecological Research [Tihany] Systèmes d'élevage méditerranéens et tropicaux Institute of Biological, Environmental and Rural Sciences CSIC, Museo Nacl Ciencias Nat The Norwegian Forest and Landscape Institute MTA Centre for Ecological Research [Tihany] The Norwegian Forest and Landscape Institute Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche] Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche] Wageningen Environmental Research (Alterra) Institut méditerranéen de biodiversité et d'écologie marine et continentale Aberystwyth University Università degli Studi di Padova = University of Padua Università degli Studi di Padova = University of Padua Wageningen Environmental Research (Alterra) Technische Universität Munchen = Technical University Munich = Université Technique de Munich MTA Centre for Ecological Research [Tihany] Universidad de Extremadura - University of Extremadura Alma Mater Studiorum Università di Bologna = University of Bologna Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche] Università degli Studi di Padova = University of Padua AGroécologie, Innovations, teRritoires Technische Universität Munchen = Technical University Munich = Université Technique de Munich Università degli Studi di Padova = University of Padua Technische Universität Munchen = Technical University Munich = Université Technique de Munich Agroscope
• Publié dans Communications Earth & Environment le 27/10/2020

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Résumé : Conversion of semi-natural habitats, such as field margins, fallows, hedgerows, grassland, woodlots and forests, to agricultural land could increase agricultural production and help meet rising global food demand. Yet, the extent to which such habitat loss would impact biodiversity and wild species is unknown. Here we survey species richness for four taxa (vascular plants, earthworms, spiders, wild bees) and agricultural yield across a range of arable, grassland, mixed, horticulture, permanent crop, for organic and non-organic agricultural land on 169 farms across 10 European regions. We find that semi-natural habitats currently constitute 23% of land area with 49% of species unique to these habitats. We estimate that conversion of semi-natural land that achieves a 10% increase in agricultural production will have the greatest impact on biodiversity in arable systems and the least impact in grassland systems, with organic practices having better species retention than non-organic practices. Our findings will help inform sustainable agricultural development.

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Fichiers liés : 2021-choisis-Commearthandenv.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Vincent DurlachDominique Bonnefont-RousselotFranck BoccaraMathilde VarretMathilde Di FilippoBertrand CariouRené ValéroSybil CharrièreMichel FarnierPierre MorangeOlivier MeilhacGilles LambertPhilippe MoulinPhilippe GillerySophie Beliard-LasserreÉric BruckertAlain CarriéJean FerrièresXavier ColletM. John John ChapmanEduardo Anglés-Cano
• Organismes : Université de Reims Champagne-Ardenne Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 CHU Pitié-Salpêtrière [AP-HP] Unité de Technologies Chimiques et Biologiques pour la Santé Centre de Recherche Saint-Antoine Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Saint-Antoine [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX - unité de recherche de l'institut du thorax Hôpital de la Conception [CHU - APHM] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon] CHU Dijon Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Diabète athérothrombose et thérapies Réunion Océan Indien Centre Hospitalier Universitaire de La Réunion Centre d'Investigation Clinique de La Réunion - INSERM Diabète athérothrombose et thérapies Réunion Océan Indien Centre Hospitalier Universitaire de La Réunion Centre d'Investigation Clinique de La Réunion - INSERM Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 Hôpital universitaire Robert Debré [Reims] Hôpital de la Conception [CHU - APHM] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Pitié-Salpêtrière [AP-HP] Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Cardiovasculaires Centre Hospitalier Universitaire de Toulouse CHU Pitié-Salpêtrière [AP-HP] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : Lipoprotein(a) is an apolipoprotein B100-containing low-density lipoprotein-like particle that is rich in cholesterol, and is associated with a second major protein, apolipoprotein(a). Apolipoprotein(a) possesses structural similarity to plasminogen but lacks fibrinolytic activity. As a consequence of its composite structure, lipoprotein(a) may: (1) elicit a prothrombotic/antifibrinolytic action favouring clot stability; and (2) enhance atherosclerosis progression via its propensity for retention in the arterial intima, with deposition of its cholesterol load at sites of plaque formation. Equally, lipoprotein(a) may induce inflammation and calcification in the aortic leaflet valve interstitium, leading to calcific aortic valve stenosis. Experimental, epidemiological and genetic evidence support the contention that elevated concentrations of lipoprotein(a) are causally related to atherothrombotic risk and equally to calcific aortic valve stenosis. The plasma concentration of lipoprotein(a) is principally determined by genetic factors, is not influenced by dietary habits, remains essentially constant over the lifetime of a given individual and is the most powerful variable for prediction of lipoprotein(a)-associated cardiovascular risk. However, major interindividual variations (up to 1000-fold) are characteristic of lipoprotein(a) concentrations. In this context, lipoprotein(a) assays, although currently insufficiently standardized, are of considerable interest, not only in stratifying cardiovascular risk, but equally in the clinical follow-up of patients treated with novel lipid-lowering therapies targeted at lipoprotein(a) (e.g. antiapolipoprotein(a) antisense oligonucleotides and small interfering ribonucleic acids) that markedly reduce circulating lipoprotein(a) concentrations. We recommend that lipoprotein(a) be measured once in subjects at high cardiovascular risk with premature coronary heart disease, in familial hypercholesterolaemia, in those with a family history of coronary heart disease and in those with recurrent coronary heart disease despite lipid-lowering treatment. Because of its clinical relevance, the cost of lipoprotein(a) testing should be covered by social security and health authorities.

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Fichiers liés : Arch CardioVasc Diseases 2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Antonio GalloLeopoldo Pérez de IslaSybil CharrièreAlexandre VimontRodrigo AlonsoOvidio Muñiz-GrijalvoJosé Díaz-DíazDaniel ZambónPhilippe MoulinÉric BruckertPedro MataSophie BéliardDenis AngoulvantFranck BoccaraBertrand CariouValérie CarreauAlain CarrieSybil CharrieresYves CottinMathilde Di FilippoPierre-Henri DucluzeauSonia DulongVincent DurlachMichel FarnierEmile FerrariDorota FerrieresJean FerrieresPhilippe GiralSophie GonbertRegis HankardJocelyn InamoOlga KalmykovaMichel KrempfJulie LemaleFrançois PaillardNoel PerettiAgnes PerrinAlain PradignacJean Pierre RabesVincent RigalleauFrançois SchielePatrick TounianRené ValéroBruno VergesCecile YelnikOlivier ZieglerRocío AguadoMa Pilar Álvarez-BañosRosa ArgüesoFrancisco ArrietaMiguel Ángel BarbaMarta CasañasJosé María CepedaRaimundo de AndrésGonzalo Díaz-SotoJose Luis Díaz-DiazMarta DieguezCeferino FaedoFrancisco FuentesJuan GarridoAurora GonzálezPablo González-BustosMa Dolores MañasMarta MauriJuan Diego MediavillaAlfredo MichánPablo MiramontesOvidio MuñizLeire PérezLeopoldo Perez de IslaXavier PintóManuel RomeroPatricia RubioJuan Sánchez Muñoz-TorreroJose Vidal-PardoAriane Sultan
• Organismes : Laboratoire d'Imagerie Biomédicale [Paris] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] Fundación Hipercolesterolemia Familiar Cardiovasculaire, métabolisme, diabétologie et nutrition Public Health Expertise [Paris, France] Fundación Hipercolesterolemia Familiar Hospital Universitario Virgen del Rocío [Sevilla] Hospital Abente y Lago [A Coruña] Institut d'Investigacions Biomèdiques August Pi i Sunyer Cardiovasculaire, métabolisme, diabétologie et nutrition CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Fundación Hipercolesterolemia Familiar Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Hôpital de la Conception [CHU - APHM] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Equipe AGING (CERPOP) Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans JACC: Cardiovascular Imaging le 22/10/2020

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Résumé : Objectives: This study aimed at investigating the additional contribution of coronary artery calcium (CAC) score to SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study) risk equation (SAFEHEART-RE) for cardiovascular risk prediction in heterozygous familial hypercholesterolemia (HeFH). Background: Common cardiovascular risk equations are imprecise for HeFH. Because of the high phenotype variability of HeFH, CAC score could help to better stratify the risk of atherosclerotic cardiovascular disease (ASCVD). Methods: REFERCHOL (French Registry of Familial Hypercholesterolemia) and SAFEHEART are 2 ongoing national registries on HeFH. We analyzed data from primary prevention HeFH patients undergoing CAC quantification. We used probability-weighted Cox proportional hazards models to estimate HRs. Area under the receiver-operating characteristic curve (AUC) and net reclassification improvement (NRI) were used to compare the incremental contribution of CAC score when added to the SAFEHEART-RE for ASCVD prediction. ASCVD was defined as coronary heart disease, stroke or transient ischemic attack, peripheral artery disease, resuscitated sudden death, and cardiovascular death. Results: We included 1,624 patients (mean age: 48.5 ± 12.8 years; men: 45.7%) from both registries. After a median follow-up of 2.7 years (interquartile range: 0.4-5.0 years), ASCVD occurred in 81 subjects. The presence of a CAC score of >100 was associated with an HR of 32.05 (95% CI: 10.08-101.94) of developing ASCVD as compared to a CAC score of 0. Receiving-operating curve analysis showed a good performance of CAC score alone in ASCVD prediction (AUC: 0.860 [95% CI: 0.853-0.869]). The addition of log(CAC + 1) to SAFEHEART-RE resulted in a significantly improved prediction of ASCVD (AUC: 0.884 [95% CI: 0.871-0.894] for SAFEHEART-RE + log(CAC + 1) vs AUC: 0.793 [95% CI: 0.779-0.818] for SAFEHEART-RE; P < 0.001). These results were confirmed also when considering only hard cardiovascular endpoints. The addition of CAC score was associated with an estimated overall net reclassification improvement of 45.4%. Conclusions: CAC score proved its use in improving cardiovascular risk stratification and ASCVD prediction in statin-treated HeFH.

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Fichiers liés : 2021 Gallo et al., The added value.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/12/2021
• Auteurs : Alain BadieSandrine DubourgJean-Charles MorettiAnna PapadopoulouDominique TardyLisa ShindoCarine Cenzon-SalvayreArnaud CoutelasAsma AmriPierre RochetteGilles A.R. ConesaPhilippe Bromblet
• Organismes : Institut de recherche sur l'architecture antique Institut de recherche sur l'architecture antique Institut de recherche sur l'architecture antique Institut de recherche sur l'architecture antique Cluster of Excellence ROOTS, Kiel University Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Interdisciplinaire de Conservation et Restauration du Patrimoine

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Salim Si-MohamedJade MiailhesPierre-Antoine RodeschSara BoccaliniHugo LacombeValérie LeitmanVincent CottinL. BousselPhilippe Douek
• Organismes : Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Hospices Civils de Lyon Modeling & analysis for medical imaging and Diagnosis Hospices Civils de Lyon Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Hospices Civils de Lyon Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Infections Virales et Pathologie Comparée - UMR 754 Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Hospices Civils de Lyon Modeling & analysis for medical imaging and Diagnosis Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Hospices Civils de Lyon Modeling & analysis for medical imaging and Diagnosis
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : The X-ray imaging field is currently undergoing a period of rapid technological innovation in diagnostic imaging equipment. An important recent development is the advent of new X-ray detectors, i.e., photon-counting detectors (PCD), which have been introduced in recent clinical prototype systems, called PCD computed tomography (PCD-CT) or photon-counting CT (PCCT) or spectral photon-counting CT (SPCCT) systems. PCD allows a pixel up to 200 microns pixels at iso-center, which is much smaller than that can be obtained with conventional energy integrating detectors (EID). PCDs have also a higher dose efficiency than EID mainly because of electronic noise suppression. In addition, the energy-resolving capabilities of these detectors allow generating spectral basis imaging, such as the mono-energetic images or the water/iodine material images as well as the K-edge imaging of a contrast agent based on atoms of high atomic number. In recent years, studies have therefore been conducted to determine the potential of PCD-CT as an alternative to conventional CT for chest imaging.

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Fichiers liés : jcm-10-05757.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Romain GarousteJérôme MunzingerAndrew LeslieJessica FisherNicolas FolcherEmma LocatelliWyndy FoyThibault ChaillonDavid J. CantrillPierre MaurizotDominique CluzelPorter P. Lowry IiPeter CraneJean-Jacques BahainPierre VoinchetHerve JourdanPhilippe GrandcolasAndré Nel
• Organismes : Institut de Systématique, Evolution, Biodiversité Botanique et Modélisation de l'Architecture des Plantes et des Végétations Stanford University Brown University Université de la Nouvelle-Calédonie Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Royal Botanic Gardens [Kew] Service Geologique de la Nouvelle-Calédonie Université de la Nouvelle-Calédonie Institut de Systématique, Evolution, Biodiversité Missouri Botanical Garden Histoire naturelle de l'Homme préhistorique Histoire naturelle de l'Homme préhistorique Institut méditerranéen de biodiversité et d'écologie marine et continentale Institut de Systématique, Evolution, Biodiversité Institut de Systématique, Evolution, Biodiversité
• Publié dans Scientific Reports le 26/10/2020

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Résumé : New Caledonia was, until recently, considered an old continental island harbouring a rich biota with outstanding Gondwanan relicts. However, deep marine sedimentation and tectonic evidence suggest complete submergence of the island during the latest Cretaceous to the Paleocene. Molecular phylogenies provide evidence for some deeply-diverging clades that may predate the Eocene and abundant post-Oligocene colonisation events. Extinction and colonization biases, as well as survival of some groups in refuges on neighbouring paleo-islands, may have obscured biogeographic trends over long time scales. Fossil data are therefore crucial for understanding the history of the New Caledonian biota, but occurrences are sparse and have received only limited attention. Here we describe five exceptional fossil assemblages that provide important new insights into New Caledonia’s terrestrial paleobiota from three key time intervals: prior to the submersion of the island, following re-emergence, and prior to Pleistocene climatic shifts. These will be of major importance for elucidating changes in New Caledonia’s floristic composition over time.

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Fichiers liés : Garrouste_etal_Scientifc_reports_2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : A. ZhukovMarilena MierlaFrédéric AuchèreSamuel GissotLuciano RodriguezElie SoubriéWilliam ThompsonBernd InhesterBogdan NiculaPatrick AntolinSusanna ParentiEric BuchlinKrzysztof BarczynskiCis VerbeeckEmil KraaikampPhilip SmithKoen StegenLaurent DollaL. HarraDavid LongU. SchühleOlena PodladchikovaRegina Aznar CuadradoLuca TeriacaMargit HaberreiterAthanassios KatsiyannisPierre RochusJean-Philippe HalainLionel JacquesDavid Berghmans
• Organismes : Solar-Terrestrial Centre of Excellence [Brussels] D.V. Skobeltsyn Institute of Nuclear Physics Solar-Terrestrial Centre of Excellence [Brussels] Institut d'astrophysique spatiale Solar-Terrestrial Centre of Excellence [Brussels] Solar-Terrestrial Centre of Excellence [Brussels] Institut d'astrophysique spatiale Universitat de les Illes Balears = Universidad de las Islas Baleares = University of the Balearic Islands ADNET Systems, Inc. Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Solar Influences Data Analysis Center [Brussels] Northumbria University [Newcastle] Institut d'astrophysique spatiale Institut d'astrophysique spatiale Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Department of Physics = Departement Physik [ETH Zürich] Solar-Terrestrial Centre of Excellence [Brussels] Solar-Terrestrial Centre of Excellence [Brussels] Mullard Space Science Laboratory Solar-Terrestrial Centre of Excellence [Brussels] Solar-Terrestrial Centre of Excellence [Brussels] Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Department of Physics = Departement Physik [ETH Zürich] Mullard Space Science Laboratory Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Physikalisch-Meteorologisches Observatorium Davos/World Radiation Center Solar Influences Data Analysis Center [Brussels] Centre Spatial de Liège Agence Spatiale Européenne = European Space Agency Centre Spatial de Liège Centre Spatial de Liège Solar-Terrestrial Centre of Excellence [Brussels]
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. The three-dimensional fine structure of the solar atmosphere is still not fully understood as most of the available observations are taken from a single vantage point. Aims. The goal of the paper is to study the three-dimensional distribution of the small-scale brightening events (“campfires”) discovered in the extreme-UV quiet Sun by the Extreme Ultraviolet Imager (EUI) aboard Solar Orbiter. Methods. We used a first commissioning data set acquired by the EUI’s High Resolution EUV telescope on 30 May 2020 in the 174 Å passband and we combined it with simultaneous data taken by the Atmospheric Imaging Assembly (AIA) aboard the Solar Dynamics Observatory in a similar 171 Å passband. The two-pixel spatial resolution of the two telescopes is 400 km and 880 km, respectively, which is sufficient to identify the campfires in both data sets. The two spacecraft had an angular separation of around 31.5° (essentially in heliographic longitude), which allowed for the three-dimensional reconstruction of the campfire position. These observations represent the first time that stereoscopy was achieved for brightenings at such a small scale. Manual and automatic triangulation methods were used to characterize the campfire data. Results. The height of the campfires is located between 1000 km and 5000 km above the photosphere and we find a good agreement between the manual and automatic methods. The internal structure of campfires is mostly unresolved by AIA; however, for a particularly large campfire, we were able to triangulate a few pixels, which are all in a narrow range between 2500 and 4500 km. Conclusions. We conclude that the low height of EUI campfires suggests that they belong to the previously unresolved fine structure of the transition region and low corona of the quiet Sun. They are probably apexes of small-scale dynamic loops heated internally to coronal temperatures. This work demonstrates that high-resolution stereoscopy of structures in the solar atmosphere has become feasible.

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Fichiers liés : aa41010-21.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Nicolas BourgonKlervia JaouenAnne-Marie BaconElise DufourJeremy MccormackN.-Han TranManuel TrostDenis FiorilloTyler E DunnClément ZanolliAlexandra J ZachwiejaPhilippe DuringerJean-Luc PoncheQuentin BoeschPierre-Olivier AntoineKira E WestawayRenaud Joannes-Boyau NoEric SuzzoniSébastien FrangeulFrançoise CrozierFrançoise Aubaile-SallenaveElise Patole EdoumbaThonglith LuangkhothViengkeo SouksavatdySouliphane BoualaphaneThongsa SayavonkhamdyPhonephanh SichanthongtipDaovee SihanamFabrice DemeterLaura L ShackelfordJean-Jacques HublinThomas Tütken
• Organismes : Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology BioArchéologie, Interactions Sociétés Environnements Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Géosciences Environnement Toulouse Biologie, anthropologie, biométrie, épigénétique, lignées : De la diversité des populations à l'individu, de l'identification à l'identité BioArchéologie, Interactions Sociétés Environnements Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Department of Human Evolution [Leipzig] BioArchéologie, Interactions Sociétés Environnements Creighton University De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie University of Minnesota Medical School Ecole et Observatoire des sciences de la terre Institut de physique du globe de Strasbourg Laboratoire Image, Ville, Environnement Ecole et Observatoire des sciences de la terre Institut de physique du globe de Strasbourg Institut des Sciences de l'Evolution de Montpellier Macquarie University [Sydney] Southern Cross University University of Johannesburg [Johannesbourg, South Africa] Diversité, adaptation, développement des plantes Éco-Anthropologie Museum d'Histoire Naturelle de La Rochelle Éco-Anthropologie University of Copenhagen = Københavns Universitet University of Illinois at Urbana-Champaign [Urbana] Collège de France - Chaire Paléoanthropologie Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University
• Publié dans Journal of Human Evolution le 27/10/2020

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Résumé : Tam Pà Ling, a cave site in northeastern Laos, has yielded the earliest skeletal evidence of Homo sapiens in mainland Southeast Asia. The reliance of Pleistocene humans in rainforest settings on plant or animal resources is still largely unstudied, mainly due to poor collagen preservation in fossils from tropical environments precluding stable nitrogen isotope analysis, the classical trophic level proxy. However, isotopic ratios of zinc (Zn) in bioapatite constitute a promising proxy to infer trophic and dietary information from fossil vertebrates, even under adverse tropical taphonomic conditions. Here, we analyzed the zinc isotope composition (66Zn/64Zn expressed as δ66Zn value) in the enamel of two teeth of the Late Pleistocene (63–46 ka) H. sapiens individual (TPL1) from Tam Pà Ling, as well as 76 mammal teeth from the same site and the nearby Nam Lot cave. The human individual exhibits relatively low enamel δ66Zn values (+0.24‰) consistent with an omnivorous diet, suggesting a dietary reliance on both plant and animal matter. These findings offer direct evidence of the broad utilization of resources from tropical rainforests by one of the earliest known anatomically modern humans in Southeast Asia.

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Fichiers liés : Bourgon_&_al_2021_JHE.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Fabiana MadottoBairbre McnicholasEmanuele RezoagliTài PhamJohn LaffeyGiacomo BellaniAntonio PesentiJohn LaffeyLaurent BrochardAndres EstebanLuciano GattinoniFrank van HarenMarco RanieriGordon RubenfeldGordon RubenfeldB. Taylor ThompsonArthur SlutskyFernando RiosFrank van HarenMohammad Omar FaruqT. SottiauxP. DepuydtFredy LoraCesar Cesar AzevedoEddy FanGuillermo BugedoHaibo QiuMarcos GonzalezJuan SileskyVladimir CernyJonas NielsenManuel JibajaTài PhamHermann WriggeDimitrios MatamisJorge Luis RaneroCharles GomersallPravin AminS. HashemianKevin ClarksonGiacomo BellaniKiyoyasu KurahashiYounsuck KohAsisclo VillagomezAmine Ali ZeggwaghLeo HeunksJon Henrik LaakeWaqar KashifJorge SynclairJose Emmanuel PaloAntero Do Vale FernandesDorel SandescYaasen ArabiVesna BumbasierevicNicolas NinJose LorenteAnders LarssonLise PiquilloudBoonsong PatjanasoontornFekri AbrougDaniel McauleyLia McnameeJavier HurtadoEd BajwaGabriel DémpaireGuy FrancoisFrancesca RabboniFabiana MadottoSara ContiHektor SulaLordian NunciAlma CaniAlan ZazuChristian DelleraCarolina InsaurraldeRisso AlejandroJulio DaldinMauricio VinzioRuben FernandezLuis CardonnetLisandro BettiniMariano Carboni BissoEmilio OsmanMariano SettenPablo LovazzanoJavier AlvarezVeronica VillarNorberto PozoNicolas GrubissichGustavo PlotnikowDaniela VasquezSantiago IlutovichNorberto TiribelliAriel ChenaCarlos PellegriniMaría SaenzElisa EstenssoroMatias BrizuelaHernan GianinettoPablo GomezValeria CerratoMarco BezziSilvina BorelloFlavia LoiaconoAdriana FernandezSerena KnowlesClaire ReynoldsDeborah InskipJennene MillerJing KongChristina WhiteheadShailesh BihariAylin SevenAmanda KrstevskiHelen RodgersRebecca MillarToni MckennaIrene BaileyGabrielle HanlonAnders AnemanJoan LynchRaman AzadJohn NealPaul WoodsBrigit RobertsMark KolHelen WongKatharina RissThomas StaudingerXavier WitteboleCaroline BerghePierre BulpaAlain DiveRik VerstraeteHerve LebbinckPieter DepuydtJoris VermassenPhilippe MeerssemanHelga CeunenJonas RosaDaniel BeraldoClaudio PirasAdenilton RampinelliÑ NassarSergio MatalounMarcelo MoockMarlus ThompsonClaudio GonçalvesAna Carolina P. AntônioAline AscoliRodrigo BiondiDanielle FonteneleDanielle NobregaVanessa SalesSuresh ShindheDk Maizatul AimanBpg Hj IsmailJohn LaffeyFrancois BeloncleKyle DaviesRob CironeVenika ManoharanMehvish IsmailEwan GoligherMandeep JassalNiall FergusonErin NishikawaAreej JaveedGerard CurleyNuttapol RittayamaiMatteo ParottoSangeeta MehtaJenny KnollAntoine PronovostSergio CanestriniAlejandro BruhnPatricio GarciaFelipe AliagaPamela FaríasJacob YumhaClaudia OrtizJavier SalasAlejandro SaezLuis VegaEduardo LabarcaFelipe MartinezNicolás CarreñoPilar LoraHaitao LiuHaibo QiuLing LiuRui TangXiaoming LuoYouzhong AnHuiying ZhaoYan GaoZhe ZhaiZheng YeWei WangWenwen LiQingdong LiRuiqiang ZhengWenkui YuJuanhong ShenXinyu LiTao YuWeihua LuYa WuXiao HuangZhenyang HeYuanhua LuHui HanFan ZhangRenhua SunHua WangShu QinBao ZhuJun ZhaoJian LiuBin LiJing LiuFa ZhouQiong LiXing ZhangZhou Li-XinQiang Xin-HuaLiangyan JiangYuan GaoXian ZhaoYuan LiXiao LiChunting WangQingchun YaoRongguo YuKai ChenHuanzhang ShaoBingyu QinQing HuangWei ZhuAi HangMa HuaYimin LiYonghao XuYu DiLong LingTie QinShou WangJunping QinYi HanSuming ZhouMonica VargasJuan JimenezManuel RojasJaime Solis-QuesadaChristian Ramirez-AlfaroJan MácaPeter SklienkaJakob GjedstedAage ChristiansenJonas NielsenBoris VillamaguaMiguel LlanoPhilippe BurtinGautier BuzancaisPascal BeuretNicolas PelletierSatar MortazaAlain MercatJonathan ChellySébastien JochmansNicolas TerziCédric DaubinGuillaume CarteauxNicolas de ProstJean-Daniel ChicheFabrice DaviaudTài PhamMuriel FartoukhGuillaume BarberetJerome BiehlerJean DellamonicaDenis DoyenJean-Michel ArnalAnais BriquetFanny KlasenLaurent PapazianArnaud FollinDamien RouxJonathan MessikaEvangelos KalaitzisLaurence DangersAlain CombesSiu-Ming AuGaetan BéduneauDorothée CarpentierElie ZogheibHervé DupontSylvie RicomeFrancesco SantoliSebastien BessetPhilippe MichelBruno GeléePierre-Eric DaninBernard GoubauxPhilippe CrovaNga PhanFrantz BerkelmansJulio BadieRomain TapponnierJosette GallySamy KhebbebJean-Etienne HerbrechtFrancis SchneiderPierre-Louis DeclercqJean-Philippe RigaudJacques DuranteauAnatole HarroisRussell ChabanneJulien MarinJean-Michel ConstantinSandrine ThibaultMohammed GhaziMessabi BoukhaznaSalem Ould ZeinJack RichecoeurDaniele CombauxFabien GrelonCharlene Le MoalElise SauvadetAdrien RobineVirginie LemialeDanielle ReuterMartin DresAlexandre DemouleDany Goldgran-ToledanoLoredana BaboiClaude GuérinRalph LohnerJens KraßlerSusanne SchäferKai ZacharowskiPatrick MeybohmAndreas ReskePhilipp SimonHans-Bernd HopfMichael SchuetzThomas BaltusMetaxia PapanikolaouTheonymfi PapavasilopoulouGiannis ZacharasVasilis OurailogloyEleni MouloudiEleni MassaEva NagyElectra StamouEllada KiourtzievaMarina OikonomouLuis AvilaCesar CortezJohanna CitalánSameer JogSafal SableBhagyesh ShahMohan GurjarArvind BaroniaMohammedfaruk MemonRadhakrishnan MuthuchellappanVenkatapura RameshAnitha ShenoyRamesh UnnikrishnanSubhal DixitRachana RhayakarNagarajan RamakrishnanVallish BhardwajHeera MahtoSudha SagarVijayanand PalaniswamyDeeban GanesanSeyed Mohammadreza HashemianHamidreza JamaatiFarshad HeidariEdel MeaneyAlistair NicholKarl KnapmanDonall O’croininEimhin DunneDorothy BreenKevin ClarksonRola JaafarRory DwyerFahd AmirOlaitan AjetunmobiAogan O’muircheartaighColin BlackNuala TreanorDaniel CollinsWahid AltafGianluca ZaniMaurizio FusariSavino SpadaroCarlo VoltaRomano GrazianiBarbara BrunettiniSalvatore PalmesePaolo FormentiMichele UmbrelloAndrea LombardoElisabetta PecciMarco BotteriMonica SavioliAlessandro ProttiAlessia MatteiLorenzo SchiavoniAndrea TinnirelloManuel TodeschiniPoliclinico GiacconeAntonino GiarratanoAndrea CortegianiSara SherAnna RossiMassimo AntonelliLuca MontiniPaolo CasalenaSergio ScafettiGiovanna PanarelloGiovanna OcchipintiNicolò PatronitiMatteo PozziRoberto BiscioneMichela PoliFerdinando RaimondiDaniela AlbieroGiulia CrapelliEduardo BeckVincenzo PotaVincenzo SchiavoneAlexandre MolinFabio TarantinoGiacomo MontiElena FratiLucia MirabellaGilda CinnellaTommaso FossaliRiccardo ColomboPierpaolo Terragni Ilaria PattarinoFrancesco MojoliAntonio BraschiErika BorottoAndrea CracchioloDaniela PalmaFrancesco RaponiGiuseppe FotiEttore VascottoAndrea CoppadoroLuca BrazziLeda FlorisGiorgio IottiAaron VentiOsamu YamaguchiShunsuke TakagiHiroki MaeyamaEizo WatanabeYoshihiro YamajiKazuyoshi ShimizuKyoko ShiozakiSatoru FutamiSekine RyosukeKoji SaitoYoshinobu KameyamaKeiko UenoMasayo IzawaNao OkudaHiroyuki SuzukiTomofumi HarasawaMichitaka NasuTadaaki TakadaFumihito ItoShin NunomiyaKansuke KoyamaToshikazu AbeKohkichi AndohKohei KusumotoAkira HirataAkihiro TakabaHiroyasu KimuraShuhei MatsumotoUshio HigashijimaHiroyuki HondaNobumasa AokiHiroshi ImaiYasuaki OginoIchiko MizuguchiKazuya IchikadoKenichi NittaKatsunori MochizukiTomoaki HashidaHiroyuki TanakaTomoyuki NakamuraDaisuke NiimiTakeshi UedaYozo KashiwaAkinori UchiyamaOlegs SabelnikovsPeteris OssYoussef HaddadKong LiewSilvio Ñamendys-SilvaYves Jarquin-BadiolaLuis Sanchez-HurtadoSaira Gomez-FloresMaria MarinAsisclo VillagomezJordana LemusJonathan FierroMavy Ramirez CervantesFrancisco Javier Flores MejiaDulce DectorDulce DectorDaniel GonzalezClaudia EstrellaJorge Sanchez-MedinaAlvaro Ramirez-GutierrezFernando GeorgeJanet AguirreJuan BuensusesoManuel PoblanoMohammed UniversityTarek DendaneAmine Ali ZeggwaghHicham BalkhiMina ElkhayariNacer SamkaouiHanane EzzouineAbdellatif BenslamaMourad AmorWajdi MaazouziNedim CimicOliver BeckMonique BrunsJeroen SchoutenMyra RiniaMonique RaaijmakersLeo HeunksHellen van WezelSerge HeinesUlrich StrauchMarc BuiseFabienne SimonisMarcus SchultzJennifer GoodsonTroy BrowneLeanlove NavarraAnna HuntRobyn HutchisonMathew BaileyLynette NewbyColin McarthurMichael KalkoffAlex McleodJonathan CasementDanielle HackingFinn AndersenMerete DolvaJon LaakeAndreas Barratt-DueKim Andre L. NoremarkEldar SøreideBrit Å. SjøbøAnne GuttormsenHector YoshidoRonald Zumaran AguilarFredy OscanoaAlain AlisasisJoanne RoblesRossini Abbie B. Pasanting-LimBeatriz TanPawel AndruszkiewiczKarina JakubowskaCristina CoxoAntónio AlvarezBruno OliveiraGustavo MontanhaNelson BarrosCarlos PereiraAntónio MessiasJorge MonteiroAna AraujoNuno CatorzeSusan MarumMaria BouwRui GomesVania BritoSilvia CastroJoana EstilitaFilipa BarrosIsabel SerraAurelia MartinhoDana TomescuAlexandra MarcuOvidiu BedreagMarius PapuricaDan CorneciSilvius Ioan NegoitaEvgeny GrigorievAlexey GritsanAndrey GazenkampfGhaleb AlmekhlafiMohamad AlbarrakGhanem MustafaKhalid MaghrabiNawal SalahuddinTharwat AisaAhmed Al JabbaryEdgardo TabhanYaseen ArabiOlivia TrinidadHasan Al DorziEdgardo TabhanStefan BolonOliver SmithJordi ManceboHernan Aguirre-BermeoJuan Lopez-DelgadoFrancisco EsteveGemma RialpCatalina FortezaCandelaria de HaroAntonio ArtigasGuillermo AlbaicetaSara de Cima-IglesiasLeticia Seoane-QuirogaAlexandra Ceniceros-BarrosAntonio Ruiz-AguilarLuis Claraco-VegaJuan Alfonso SolerMaria del Carmen LorenteCecilia HermosaFederico GordoMiryam Prieto-GonzálezJuan López-MessaManuel PerezCesar PerezRaquel Montoiro AllueFerran Roche-CampoMarcos Ibañez-SantacruzSusana TempranoMaria PintadoRaul de PabloPilar Ricart Aroa GómezSilvia Rodriguez RuizSilvia Iglesias MolesMª Teresa JuradoAlfons ArizmendiEnrique PiacentiniNieves FrancoTeresa HonrubiaMeisy Perez ChengElena Perez LosadaJavier BlancoLuis YusteCecilia Carbayo-GorrizFrancisca Cazorla-BarranqueroJavier AlonsoRosa AldaÁngela AlgabaGonzalo NavarroEnrique CereijoEsther Diaz-RodriguezDiego Pastor MarcosLaura Alvarez MonteroLuis Herrera ParaRoberto Jimenez SanchezMiguel Angel Blasco NavalpotroRicardo Diaz AbadRaquel Montiel Gonz Á LezDácil Parrilla ToribioAlejandro CastroMaria Jose D. ArtigaOscar PenuelasTomas RoserMoreno OlgaElena Gallego CurtoRocío Manzano SánchezVallverdu ImmaGarcia ElisabetLaura ClaveriasMonica MagretAna PellicerLucia RodriguezJesús Sánchez-BallesterosÁngela González-SalamancaAntonio JimenezFrancisco HuertaJuan Carlos J. Sotillo DiazEsther Bermejo LopezDavid MoyaAlec AlfonsoPalazon Sanchez Eugenio LuisPalazon Sanchez CesarSánchez RafaelCorcoles VirgilioNoelia RecioRichard AdamssonChristian RylanderBernhard HolzgraefeLars BromanJoanna WessberghLinnea PerssonFredrik SchiölerHans KedelvAnna Oscarsson TibblinHenrik AppelbergLars HedlundJohan HellebergKarin ErikssonRita GlietschNiklas LarssonIngela NygrenSilvia NunesAnna-Karin MorinThomas KanderAnne AdolfssonLise PiquilloudHervé ZenderCorinne Leemann-RefondiniSouheil ElatrousSlaheddine BouchouchaImed ChoucheneIslem OuanesLa MarsaAsma Ben SouissiSalma KamounOktay DemirkiranMustafa AkerEmre ErbabacanIlkay CeylanNermin Kelebek GirginMenekse OzcelikNecmettin ÜnalBasak Ceyda MecoOnat AkyolSuleyman DermanBarry KennedyKen ParharLatha SrinivasaLia McnameeDanny McauleyPhil HopkinsClare MellisVivek KakarDan HadfieldAndre VercueilKaushik BhowmickSally HumphreysAndrew FergusonRaymond MckeeAshok RajDanielle FawkesPhilip WattLinda TwoheyRajeev ThomasAlex MortonVarsha KadabaMark SmithAnil HormisSanthana KannanMiriam NamihHenrik ReschreiterJulie CamsooksaiAlek KumarSzabolcs RugonfalviChristopher NuttOrla OneillColette SeasmanGed DempseyChristopher ScottHelen EllisStuart MckechniePaula HuttonNora Di TomassoMichela VitaleRuth GriffinMichael DeanJulius CranshawEmma WillettNicholas IoannouSarah GillisPeter CsabiRosaleen MacfadyenHeidi DawsonPieter PreezAlexandra WilliamsOwen BoydLaura Ortiz-Ruiz de GordoaJon BramallSophie SymmondsSimon ChauTim WenhamTamas SzakmanyPiroska Toth-TarsolyKatie MccalmanPeter AlexanderLorraine StephensonThomas CollyerRhiannon ChapmanRaphael CooperRussell AllanMalcolm SimDavid WrathallDonald IrvineKim ZantuaJohn AdamsAndrew BurtenshawGareth SellorsIngeborg WeltersKaren WilliamsRobert HessellMatthew OldroydCeri BattleSuresh PillaiIstvan KajtorMageswaran SivashanmugavelSinead OkaneAdrian DonnellyAniko FrigyikJon CarelessMartin MayRichard StewartT. John TrinderSamantha HaganMatt WiseJade ColeCaroline MacfieAnna DowlingJavier HurtadoNicolás NinJavier HurtadoEdgardo NuñezGustavo PittiniRuben RodriguezMaría ImperioCristina SantosAlberto DeicasCarolina SerraAditya UppalapatiGhassan KamelValerie Banner-GoodspeedJeremy BeitlerSatyanarayana Reddy MukkeraShreedhar KulkarniJarone LeeTomaz MesarJohn Shinn IiiDina GomaaChristopher TainterJarone LeeTomaz MesarJarone LeeDale YeattsJessica WarrenMichael LanspaRussel MillerColin GrissomSamuel BrownPhilippe BauerRyan GosselinBarrett KitchJason CohenScott BeegleRenaud GueretAiman TulaimatShazia ChoudryWilliam StiglerHitesh BatraNidhi HuffKeith LambTrevor OettingNicholas MohrClaine JudyShigeki SaitoFayez KheirFayez KheirAdam SchlichtingAngela DelsingDaniel CrouchMary ElmasriDaniel CrouchDina IsmailKyle DreyerThomas BlakemanKyle DreyerDina GomaaRebecca BaronCarolina Quintana GrijalbaPeter HouRaghu SeethalaImo AisikuGalen HendersonGyorgy FrendlSen-Kuang HouRobert OwensAshley SchomerVesna BumbasirevicBojan JovanovicMaja SurbatovicMilic VeljovicJohn LaffeyGiacomo BellaniAntonio Pesenti
• Organismes : Ospedale Multimedica Sesto San Giovanni National University of Ireland [Galway] Università degli Studi di Milano-Bicocca = University of Milano-Bicocca San Gerardo Hospital Company Monza Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Faculté de Médecine Paris-Saclay National University of Ireland [Galway] Università degli Studi di Milano-Bicocca = University of Milano-Bicocca San Gerardo Hospital Company Monza Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Critical Care le 31/10/2020

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Résumé : Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Method The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073.

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Fichiers liés : s13054-021-03465-0.pdf

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