Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Romain GueryFelipe SuarezFanny LanternierMarie Elisabeth BougnouxHervé LecuyerVéronique Avettand-FenoelDavid SibonLaurent FrenzelJean-Herlé RaphalenPhilippe HeliasPhilippe RenaudierFlorin SantaMarc LecuitOlivier LortholaryOlivier HermineClaire AguilarAmbroise Marçais
• Organismes : Service des Maladies infectieuses et tropicales [CHU Necker] Service des Maladies infectieuses et tropicales [CHU Necker] Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades] Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades] Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades] Service d'Hématologie Adultes [CHU Necker] Service d'Hématologie Adultes [CHU Necker] Service d'Anesthésie Réanimation [CHU Necker] CHU Pointe-à-Pitre / Abymes [Guadeloupe] Hôpital Pierre Zobda-Quitman [CHU de la Martinique] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Service des Maladies infectieuses et tropicales [CHU Necker] Biologie des Infections - Biology of Infection Service des Maladies infectieuses et tropicales [CHU Necker] Service d'Hématologie Adultes [CHU Necker] Service des Maladies infectieuses et tropicales [CHU Necker] Service d'Hématologie Adultes [CHU Necker] Institut Necker Enfants-Malades
• Publié dans Annals of Hematology le 26/10/2020

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Résumé : Patients treated for adult T-Cell leukemia/lymphoma (ATL) have a poor prognosis and are prone to infectious complications which are poorly described. As the French reference center for ATL, we retrospectively analyzed 47 consecutive ATL (acute, n = 23; lymphoma, n = 14; chronic, n = 8; smoldering, n = 2) patients between 2006 and 2016 (median age 51 years, 96% Afro-Caribbean origin). The 3-year overall survival (OS) was 15.8%, 11.3%, and 85.7% for acute, lymphoma, and indolent (chronic and smoldering) forms respectively. Among aggressive subtypes, 20 patients received, as frontline therapy, high dose of zidovudine and interferon alfa (AZT-IFN⍺) resulting in an overall response rate (ORR) of 39% (complete response [CR] 33%) and 17 chemotherapy resulting of an ORR of 59% (CR 50%). Ninety-five infections occurred in 38 patients, most of whom had an acute subtype (n = 73/95; 77%). During their follow-up, patients receiving frontline chemotherapy or frontline AZT-IFNα developed infections in 74% (n = 14/19) and 89% (n = 24/27) of the cases respectively. Sixty-four (67%) of infections were microbiologically documented. Among them, invasive fungal infections (IFI, n = 11) included 2 Pneumocystis jirovecii pneumonia, 5 invasive aspergillosis, and 4 yeast fungemia. IFI exclusively occurred in patients with acute subtype mostly exposed to AZT-IFNα (n = 10/11) and experiencing prolonged (> 10 days) grade 4 neutropenia. Patients with aggressive subtype experiencing IFI had a lower OS than those who did not (median OS 5.4 months versus 18.4 months, p = 0.0048). ATL patients have a poor prognosis even in the modern era. Moreover, the high rate of infections impacts their management especially those exposed to AZT-IFNα.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Véronique V. Gayrard-TroyJessika MoreauNicole Picard-HagenVirginie HeliesPhilippe MarchandJean-Philippe AntignacPierre‐louis ToutainRoger Leandri
• Organismes : Exposition, Perturbation Endocrino-métabolique et Reproduction Centre Hospitalier Universitaire de Toulouse ToxAlim Exposition, Perturbation Endocrino-métabolique et Reproduction Exposition, Perturbation Endocrino-métabolique et Reproduction Génétique Physiologie et Systèmes d'Elevage Laboratoire d'étude des Résidus et Contaminants dans les Aliments Laboratoire d'étude des Résidus et Contaminants dans les Aliments Innovations Thérapeutiques et Résistances Royal Veterinary College Exposition, Perturbation Endocrino-métabolique et Reproduction Centre Hospitalier Universitaire de Toulouse
• Publié dans Environmental Health Perspectives le 28/10/2020

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Résumé : Background: Although in vivo studies of internal exposure to hazardous substances have been carried out for many years, there is room for progress to improve their informative value while adhering to the four R’s: replacement, reduction, refinement, and responsibility rule. Objectives: The objective of the study was to illustrate how toxicokinetic (TK) study design and data analysis can be implemented under the 4R rule to plan a chronic dosage regimen for investigating TK/toxicodynamic (TD) relationships. Methods: The intravenous (IV) and oral serum concentrations of eight hazardous environmental contaminants including 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (pp′DDE), ß-Hexachlorocyclohexane (β-HCH), hexachlorobenzene (HCB), 2,2′4,4′-tetrabromodiphenyl ether (BDE-47), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di(2ethylhexyl)phthalate (DEHP), and bisphenol S (BPS) were obtained after mixture dosing in rabbits using a sparse sampling design. Data were comprehensively analyzed using nonlinear mixed effect (NLME) modeling. Results: The short persistence of BPS and of the DEHP metabolite (mono-2-ethylhexyl phthalate), reflected by their mean residence times (MRT) of a few hours, was due to their efficient clearance (CL, 3.2 and 0.47L/kg/h). The longer MRT of the other compounds (1–48 d) resulted either from their extremely low clearance (lower than 0.01L/kg/h for PFOA and PFOS) or from their very large volume of distribution (VSS) ranging from 33 to 45L/kg. Estimates of CL, VSS, and bioavailability were used to compute the oral loading and daily maintenance doses required to attain a nominal steady-state serum concentration of 1 ng/mL. Simulations with the NLME model were applied to predict the serum concentration profile and to contrast the differential rates of accumulation in the central vs. peripheral compartments. Conclusion: NLME modeling of the IV and oral TK of hazardous environmental contaminants, in rabbits while fulfilling the 4R rule, was able to provide the physiological basis for interspecies extrapolation of exposure rates in a TK/TD approach to risk assessment

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Fichiers liés : EHP8957(1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Maïa ProisyPierre-Hugues VivierBaptiste MorelBertrand BruneauCatherine Sembely-TaveauSolène VacheresseAnne DevillersJoseph LecloirecCaroline Bodet-MilinMarine DuboisStéphanie HamonicEmma BajeuxAnne GanivetCatherine AdamsbaumCatherine TréguierLydie AbaleaSéverine Croly-LabourdettePhong Dam HieuMurielle DobrzynskiBertrand FenollPierre ForlodouChristiane Le BotJérémie LefrancMélanie LesoeurPhilippe MériotSylviane PeudenierSolène QuerelloPierre-Yves SalaünPierre OlivierLaurent MartrilleAnne Borsa-DorionMarie-Agnès GalloyLaurence Mainard-SimardEmmanuel RaffoSylvie Cavare-VigneronMichel ClaudonOlivier KleinEmmanuelle SchmittSerge Le TaconOlivier MorelLucie LappFrançoise Bodere-KraeberCaroline MilinJuliette FleuryLoïc GeffroySophie HamelThomas LefrancoisMarie-Pierre LongisEmmanuelle MayrargueGeorges PicherotMarie-Pierre QuéréJean-Christophe RozéNathalie VabresRenaud BouvetMariannick Le GueutLaurent RiffaudMartine BalençonPierre BétrémieuxMadeleine ChapuisVéronique ChasleAlain DabadieLéna DamajPierre DarnaultFrançois de La BrièreSéverine DelahayeRegis DuvauferrierCéline FargesBernard FraisseThéophile GaillotMaryse GardinCécile GauvritMarie-Aline GuittenySylvette MarleixSilvia NapuriMichel RousseyCéline RozelOlivier TirelCatherine VignaudPhilippe ViolasEric WodeyMarion PierrePatrick PladysSaad Abu-AmaraBruno BachyMarie Brasseur-DaudruyJean-Nicolas DacherPascal DelmonJoël Lechevallier-AmaraBénédicte LereboursJulien LerouxFrançois ProustSophie RigalJean-Louis BaulieuYann VenelCarpentier ElodieAlain ChantepieJulie ChantreuilMathieu ComeBenoit de CourtivronFrançois LabartheYves MarotMyriam Pepin-DonatDominique SirinelliNadine TraversAnnie Urvois-GrangePatrick O'ByrneAntoine ListratMarie-Luce Barge-GalernJoseph Le CloirecPierre VeraI. Kone-PautKumaran DeivaPhilippe Chaumet-RiffaudGilles GrimonFrederique ArchambaudFerielle ZenkhriCaroline GaleottiNancy Sevette-BéchardOlivier ProdhommeCéline LeconteArmelle HaquetAurélie BourdonMélanie SainmontLoic De-PontualNicolas SellierThanh-Van TrieuClaire de Labriolle-Vaylet
• Organismes : Département de Radiologie [Rennes] Hôpital Charles Nicolle [Rouen] Centre Hospitalier Régional Universitaire de Tours Département de Radiologie [Rennes] Centre Hospitalier Régional Universitaire de Tours Département de Radiologie [Rennes] Département de médecine nucléaire [Rennes] Service de médecine nucléaire [Rouen] Centre de Recherche en Cancérologie et Immunologie Nantes-Angers Département de Radiologie [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire [Rennes] Département de Radiologie [AP-HP Hôpital Bicêtre] Département de Radiologie [Rennes] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans European Radiology le 23/10/2020

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Résumé : Objectives: To assess the contribution of whole-body magnetic resonance imaging (WBMRI) and bone scintigraphy (BS) in addition to skeletal survey (SS) in detecting traumatic bone lesions and soft-tissue injuries in suspected child abuse. Methods: In this prospective, multicentre, diagnostic accuracy study, children less than 3 years of age with suspected physical abuse were recruited. Each child underwent SS, BS and WBMRI. A blinded first review was performed in consensus by five paediatric radiologists and three nuclear medicine physicians. A second review investigated discrepancies reported between the modalities using a consensus result of all modalities as the reference standard. We calculated the sensitivity, specificity and corresponding 95% confidence interval for each imaging modality (SS, WBMRI and BS) and for the combinations [SS + WBMRI] and [SS + BS]. Results: One hundred seventy children were included of which sixty-four had at least one lesion. In total, 146 lesions were included. The sensitivity and specificity of each examination were, respectively, as follows: 88.4% [95% CI, 82.0-93.1] and 99.7% [95% CI, 99.5-99.8] for the SS, 69.9% [95% CI, 61.7-77.2] and 99.5% [95% CI, 99.2-99.7] for WBMRI and 54.8% [95% CI, 46.4-63.0] and 99.7% [95% CI, 99.5-99.9] for BS. Sensitivity and specificity were, respectively, 95.9% [95% CI, 91.3-98.5] and 99.2% [95% CI, 98.9-99.4] for the combination SS + WBMRI and 95.2% [95% CI, 90.4-98.1] and 99.4% [95% CI, 99.2-99.6] for the combination SS + BS, with no statistically significant difference between them. Conclusion: SS was the most sensitive independent imaging modality; however, the additional combination of either WBMRI or BS examinations offered an increased accuracy. Key points: • SS in suspected infant abuse was the most sensitive independent imaging modality in this study, especially for detecting metaphyseal and rib lesions, and remains essential for evaluation. • The combination of either SS + BS or SS + WBMRI provides greater accuracy in diagnosing occult and equivocal bone injuries in the difficult setting of child abuse. • WBMRI is a free-radiation technique that allows additional diagnosis of soft-tissue and visceral injuries.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Antonio Vallejo-VazChristophe A.T. StevensAlexander R.M. LyonsKanika DharmayatTomas FreibergerG. Kees HovinghPedro MataFrederick RaalRaul SantosHandrean SoranGerald WattsMarianne AbifadelCarlos Aguilar-SalinasKhalid AlhabibMutaz AlkhnifsawiWael AlmahmeedFahad AlnouriRodrigo AlonsoKhalid Al-RasadiAhmad Al-SarrafNasreen Al-SayedFrancisco AraujoTester AshavaidMaciej BanachSophie BéliardMarianne BennChristoph BinderMartin BogsrudMafalda BourbonKrzysztof ChlebusPablo CorralKairat DavletovOlivier DescampsRonen DurstMarat EzhovDan GaitaJacques GenestUrh GroseljMariko Harada-ShibaKirsten HolvenMeral KayikciogluWeerapan KhovidhunkitKatarina LalicGustavs LatkovskisUlrich LaufsEvangelos LiberopoulosMarcos Lima-MartinezJie LinVincent MaherA. David MaraisWinfried MärzErkin MirrakhimovAndré MiserezOlena MitchenkoHapizah NawawiBørge NordestgaardAndrie PanayiotouGyörgy ParaghZaneta PetrulionieneBelma PojskicArman PostadzhiyanKatarina RaslovaAshraf RedaŽeljko ReinerFouzia SadiqWilson Ehidiamen SadohHeribert SchunkertAleksandr ShekMario StollErik StroesTa-Chen SuTavintharan SubramaniamAndrey SusekovMyra TilneyBrian TomlinsonThanh Huong TruongAlexandros TselepisAnne Tybjærg-HansenAlejandra Vázquez CárdenasMargus ViigimaaLuya WangShizuya YamashitaJohn J.P. KasteleinÉric BruckertBranislav VohnoutLaura SchreierJing PangChristoph EbenbichlerHans DieplingerReinhold InnerhoferYvonne Winhofer-StöcklSusanne Greber-PlatzerKonstantin KrychtiukWalter SpeidlHermann ToplakKurt WidhalmThomas StulnigKurt HuberFlorian HöllerlGersina Rega-KaunLucas KleemannMartin MäserSabine Scholl-BürgiChristoph SälyFlorian MayerGaelle SablonEric TarantinoCharlotte NzeyimanaLamija PojskicIbrahim SisicAzra NalbanticCinthia JannesAlexandre PereiraJosé E. KriegerIvo PetrovAssen GoudevFedya NikolovSnejana TishevaYoto YotovIvajlo TzvetkovAlexis BaassJean BergeronSophie BernardDiane BrissonLiam BrunhamLubomira CermakovaPatrick CoutureGordon FrancisDaniel GaudetRobert HegeleEtienne KhouryG.B. John ManciniBrian MccrindleMartine PaquetteIsabelle RuelAda CuevasSylvia AsenjoXumin WangKang MengXiantao SongQiang YongTao JiangZiyou LiuYanyu DuanJing HongPucong YeYan ChenJianguang QiZesen LiuYuntao LiChaoyi ZhangJie PengYa YangWei YuQian WangHui YuanShitong ChengLong JiangMei ChongJian JiaoYue WuWenhui WenLiyuan XuRuiying ZhangYichen QuJianxun HeXuesong FanZhenjia WangElaine ChowIvan PećinDražen PericaPhivos SymeonidesMichal VrablikRichard CeskaVladimir SoskaLukas TichyVera AdamkovaJana FranekovaRenata CifkovaPavel KramlKaterina VonaskovaJana CepovaMagdalena DusejovskaLenka PavlickovaVladimir BlahaHana RosolovaBarbora NussbaumerovaRoman CibulkaHelena VaverkovaLubica CibickovaZdenka KrejsovaKaterina RehouskovaPavel MalinaMilena BudikovaVaclava PalanovaLucie SolcovaAlena LubasovaHelena PodzimkovaJuraj BujdakJiri VeselyMarta JordanovaTomas SalekRobin UrbanekStanislav ZemekJan LackoHana HalamkovaSona MachacovaSarka MalaEva CubovaKaterina ValoskovaLukas BurdaAhmed BendaryIhab DaoudSameh EmilAtef ElbahrySamir RaflaOsama SanadGhada KazamelMohamed AshrafMohamed SobhyAmro El-HadidyMohamed ShafySaif KamalMohamed BendaryGrete TalvisteDenis AngoulvantFranck BoccaraBertrand CariouValérie CarreauAlain CarrieSybil CharrieresYves CottinMathilde Di-FillipoPierre DucluzeauSonia DulongVincent DurlachMichel FarnierEmile FerrariDorota FerrieresJean FerrieresAntonio GalloRegis HankardJocelyne InamoJulie LemalePhilippe MoulinFrançois PaillardNoel PerettiAgnès PerrinAlain PradignacJean RabesVincent RigalleauAriane SultanFrançois SchielePatrick TounianRené ValéroBruno VergesCécile YelnikOlivier ZieglerIra HaackNina SchmidtAlexander DresselIsabel KleinJutta ChristmannAntonia SonntagChristine StumppDiana BogerDana BiedermannMonica M.N. UsmeF. Ulrich BeilGerald KloseChristel KönigIoanna Gouni-BertholdBritta OtteGereon BöllAnja KirschbaumJürgen MerkeJohannes SchollThomas SegietMarco GebauerFlorentina PredicaManfred MayerFrank LeistikowSabine Füllgraf-HorstCornelius MüllerMelanie SchülerJudith WienerKonrad HeinPeter BaumgartnerStefan KopfReinhold BuschMichael SchömigStephan MatthiasNicole Allendorf-OstwaldBruno FinkDieter BöhmAlexander JäkelAnn-Cathrin KoschkerRüdiger SchweizerAnja VogtKlaus ParhoferWolfgang KönigWibke ReinhardAndrea BässlerAlexander StadelmannVolker SchraderJulius KatzmannAdrienne TarrElisabeth Steinhagen-ThiessenUrsula KassnerGerret PaulsenJürgen HombergerClaudia ZemmrichWolfgang SeegerKathrin BiolikDorothee DeissCorinna RichterElina PantchechnikovaElena DornUlrike SchatzUlrich JuliusAntje SpensTobias WiesnerMichael SchollChristos RizosNikolaos SakkasMoses ElisafIoannis SkoumasKonstantinos TziomalosLoukianos RallidisVasileios KotsisMichalis DoumasVasileios AthyrosEmmanouil SkalidisGenovefa KolovouAnastasia GaroufiEleni BilianouIosif KoutagiarDimitrios AgapakisEstela KiouriChristina AntzaNiki KatsikiEvangelos ZacharisAchilleas AttilakosGeorge SfikasCharalambos KoumarasPanagiotis AnagnostisGeorgia AnastasiouGeorge LiamisAmalia-Despoina KoutsogianniZsolt KarányiMariann HarangiLászló BajnokMária AudikovszkyLászló MárkBéla BenczúrIstván ReiberGergely NagyAndrás NagyLakshmi ReddySwarup A.V. ShahChandrashekhar PondeJamshed DalalJitendra P.S. SawhneyIshwar VermaMays AltaeyKhalid Al-JumailyDilshad RasulAli AbdalsahibAmer JabbarMohanad Al-AgeediRuth AgarHofit CohenAvishay EllisDov GavishvDror HaratsYaacov HenkinHila KnoblerLeah LeavitEran LeitersdorfArdon RubinsteinDaniel SchurrShoshi ShpitzenAuryan SzalatManuela CasulaVeronica ZampoleriMarta GazzottiElena OlmastroniRiccardo SarzaniClaudio FerriElena RepettiCarlo SabbàAntonio Carlo BossiClaudio BorghiSandro MuntoniFrancesco CipolloneFrancesco PurrelloArturo PujiaAngelina PassaroRossella MarcucciValerio PecchioliLivia PisciottaGiuseppe MandraffinoFabio PellegattaGiuliana MombelliAdriana BranchiAnna Maria FiorenzaCristina PederivaJosè Pablo WerbaGianfranco ParatiFrancesca CarubbiLorenzo IughettiArcangelo IannuzziGabriella IannuzzoPaolo CalabròMaurizio AvernaGiacomo BiasucciSabina ZambonAnna Rita RosciniChiara TrentiMarcello ArcaMassimo FedericiMaria del BenAndrea BartuliAndrea GiaccariAntonio PipoloNadia CitroniOrnella GuardamagnaKatia BonomoAndrea BensoGianni BioloLorenzo MaroniAlessandro LupiLuca BonanniMaria Grazia ZentiKota MatsukiMika HoriMasatsune OguraDaisaku MasudaTakuya KobayashiKumiko NagahamaMohammed Al-JarallahMirjana RadovicOlga LunegovaErkayim BektashevaElyor KhodzhiboboevAndrejs ErglisDainus GilisGeorgijs NesterovicsVita SaripoRuta MeiereArta Upena-RozemicenaElizabete TeraudaSelim JambartPetra KhourySandy ElbitarCarine AyoubYoumna GhalebUrte AliosaitieneSandra KutkieneNoor A.M. KasimNoor S.M. NorAnis RamliSuraya RazakAlyaa Al-KhateebSiti H.S.A. KadirSuhaila MuidThuhairah RahmanSazzli KasimAhmad B.M. RadziKhairul IbrahimSalmi RazaliZaliha IsmailRohana GhaniMuhammad I.A. HafidzAng ChuaMarshima RosliMuthukkaruppan AnnamalaiLay TehRafezah RazaliYung ChuaAzhari RosmanAbdul SanusiNor A.A. MuradA. Rahman A. JamalSukma NazliAimi RazmanNorhidayah RosmanRadzi RahmatNur HamzanC. AzzopardiRoopa MehtaAlexandro MartagonGabriela A.G. RamirezNeftali E.A. VillaArsenio VazquezDaniel Elias-LopezGustavo RetanaBetsabel RodriguezJose J.C. MacíasAlejandro ZazuetaRocio AlvaradoJulieta D.M. PortanoHumberto LopezLeobardo Sauque-ReynaLaura G.G. HerreraLuis E.S. MendiaHumberto Garcia AguilarElizabeth CooremansBerenice AparicioVictoria ZubietaPerla A.C. GonzalezAldo Ferreira-HermosilloNacu PortillaGuadalupe DominguezAlinna Y.R. GarciaHector E.A. CazaresJesus GonzalezCarla V.M. ValenciaFrancisco PadillaRamon PradoManuel de Los Rios IbarraRuy D.A. VillicañaKarina J.A. RiveraRicardo CarreraJose AlvarezJose C.A. MartinezManuel de Los Reyes Barrera BustilloGonzalo VargasRoberto ChaconMario H.F. AndradeAshanty OrtegaHector AlcalaLaura E.G. de LeonBerenice GuzmanJose J.G. GarciaJuan C.G. CuellarJose R.G. CruzAnell Hernandez GarciaJesus R.H. AlmadaUrsulo HerreraFabiola SobrevillaEduardo RodriguezCristina SibajaAlma B.M. RodriguezJose C.M. OyervidesDaniel I.P. VazquezEduardo A.R. RodriguezMa L.R. OsorioJuan SaucedoMargarita TamayoLuis A.V. TalaveraLuis E.V. ArroyoEloy A.Z. CarrilloAlphonsus IsaraDarlington ObasekiKhalid Al-WailiFahad Al-ZadjaliIbrahim Al-ZakwaniMohammed Al-KindiSuad Al-MukhainiHamida Al-BarwaniAsim RanaLahore S.U. ShahEwa StarosteckaAgnieszka KonopkaJoanna LewekMarcin BartłomiejczykMariusz GąsiorKrzysztof DyrbuśJacek JóźwiakMarcin GruchałaMarcin PajkowskiMarzena Romanowska-KocejkoMarta Żarczyńska-BuchowieckaMagdalena ChmaraBartosz WasągAleksandra ParczewskaNatasza Gilis-MalinowskaJustyna Borowiec-WolnaAneta StróżykMarlena WośAleksandra Michalska-GrzonkowskaAna MedeirosAna AlvesFrancisco SilvaGoreti LobarinhasIsabel PalmaJose de MouraMiguel RicoQuitéria RatoPatrícia PaisSusana CorreiaOana MoldovanMaria VirtuosoJose SalgadoInes ColaçoAndreea DumitrescuCalin LengherSvetlana MosteoruAlexey MeshkovAlexandra ErshovaTatiana RozkovaVictoria KornevaKuznetsova YuVitaliy ZafirakiMikhail VoevodaVictor GurevichDmitry DuplyakovYulia RaginoMaya SafarovaIgor ShaposhnikFahmi AlkafAlia KhudariNawal RwailiFaisal Al-AllafMohammad AlghamdiMohammed BataisTurky AlmigbalAbdulhalim KinsaraAshraf H.A. AlqudaimiZuhier AwanOmer ElaminHani AltaradiNatasa RajkovicLjiljana PopovicSandra SinghLjubica StosicIva RasulicNebojsa LalicCarolyn LamTan V LeEric L.T. SiangSanjaya DissanayakeJustin I-ShingTai ShyongTerrance C.S. JinKarin BalinthIngrid BuganovaLubomira FabryovaMichaela KadurovaAlexander KlabnikMiriam KozárováJana SirotiakovaTadej BattelinoJernej KovacMatej MlinaricUrsa SustarKatarina PodkrajsekZlatko FrasBorut JugMatija CevcGillian PilcherD.J. BlomK.H. WolmaransB.C. BriceOvidio Muñiz-GrijalvoJose Díaz-DíazLeopoldo de IslaFrancisco FuentesLina BadimonFrançois MartinAngela LuxNien-Tzu ChangPoranee GanokrojMehmet AkbulutGökhan AliciFahri BayramLevent CanAhmet CelikCeyhun CeyhanFatma CoskunMesut DemirSabri DemircanVolkan DoganEmre DurakoglugilIbrahim DuralOmer GedikliAysa HaciogluMuge IldizliSalih KilicBahadir KirilmazMerih KutluAytekin OguzOner OzdoganErsel OnratSavas OzerTevfik SabuncuTayfun SahinFatih SivriAlper SonmezAhmet TemizhanSelim TopcuAbdullah TuncezMirac VuralMustafa YenercagDilek YesilbursaZerrin YigitAytul YildirimAylin YildirirMehmet YilmazBassam AtallahMahmoud TrainaHani SabbourDana HayNeama LuqmanAbubaker ElfatihArshad AbdulrasheedSee KwokNicolas OcaXimena ReyesRano AlievaRavshanbek KurbanovShavkat HoshimovUlugbek NizamovAdolat ZiyaevaGuzal AbdullaevaDoan DoMai N.T. NguyenNgoc KimThanh LeHong LeLale TokgozogluAlberico CatapanoKausik Ray
• Organismes : Imperial College London European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] Equipe AGING (CERPOP) European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] Centre Hospitalier Régional Universitaire [Montpellier] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden] European Atherosclerosis Society [Göteborg, Sweden]
• Publié dans The Lancet le 02/11/2020

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Résumé : The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Mathieu ChalouniStanislas PolPhilippe SogniHelene FontaineKarine LacombeJean-Marc LacombeLaure EsterleCeline DorivalMarc BourliereFirouze Bani-SadrVictor de LedinghenDavid ZucmanDominique LarreyDominique Salmon-CéronFabrice CarratLinda WittkopAnrs C. O. Hepather Cohorts Study Groups Anrs Co13 HepavihV. Martinez
• Organismes : Team MORPH3EUS Bordeaux population health Physiopathologie du système immunitaire Hôpital Cochin [AP-HP] Université Paris Cité Physiopathologie du système immunitaire Hôpital Cochin [AP-HP] Université Paris Cité Physiopathologie du système immunitaire Hôpital Cochin [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] INSERM-TRANSFERT [Paris] Team MORPH3EUS Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital Saint-Joseph [Marseille] Hôpital Robert Debré Centre Hospitalier Universitaire de Bordeaux Bordeaux Research In Translational Oncology [Bordeaux] Hôpital Foch [Suresnes] Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Université Paris Cité Hôpital Cochin [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Team MORPH3EUS Centre Hospitalier Universitaire de Bordeaux
• Publié dans HIV Medicine le 26/10/2020

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Résumé : OBJECTIVES: HIV-coinfected patients experience higher incidences of non-liver-related cancers than HCV-monoinfected patients. Chronic inflammation, immunosuppression, but also higher tobacco or alcohol consumption and metabolic dysregulation could explain this higher risk. We aimed to estimate the direct, indirect and total effects of HIV coinfection on the risk of non-liver-related cancers in HCV participants treated with direct-acting antivirals (DAAs). METHODS: Up to four HCV-monoinfected participants from the ANRS CO22 HEPATHER cohort were matched by age and sex to HIV/HCV-coinfected participants from the ANRS CO13 HEPAVIH cohort. Participants were followed from DAA initiation until the occurrence of a non-liver-related cancer. Counterfactual mediation analysis was carried out to estimate the direct (chronic inflammation and immunosuppression), indirect (tobacco and alcohol consumption and metabolic syndrome) and total effect of HIV coinfection on the risk of non-liver-related cancers. RESULTS: 548 HIV/HCV-coinfected and 2016 monoinfected participants were included. Overall, HIV coinfection was associated with a 3.7-fold [95% confidence interval (CI): 1.7-7.0] higher risk of non-liver-related cancers in HCV participants. This increased risk was explained by significant direct effect [hazard ratio (HR) = 3.4, 95% CI: 1.7-6.6] but not indirect effect (HR = 1.1, 95% CI: 0.8-1.5) of HIV coinfection. CONCLUSIONS: In HCV participants treated with DAAs, the direct effect of HIV coinfection, reflecting chronic inflammation and immunosuppression, was associated with a 3.7-fold higher risk of non-liver-related cancer. By contrast, the indirect effect of HIV coinfection, reflecting higher tobacco and alcohol consumption and metabolic dysregulation, was not significantly associated with the risk of non-liver-related cancers.

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Fichiers liés : hal-03361010.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Thi Loi Daovan Thuan HoangTran Duc Anh LyJean Christophe LagierSophie Alexandra BaronDidier RaoultPhilippe ParolaJohan CourjonPierre MartyHervé ChaudetPhilippe Gautret
• Organismes : Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Université Côte d'Azur Université Côte d'Azur Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes
• Publié dans Clinical Microbiology and Infection le 30/10/2020

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Fichiers liés : S1198743X21001154.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/10/2021
• Auteurs : Guillaume AussedatDelphine Maucort-BoulchPhilippe ReyViolaine SafarLionel KarlinMad Helenie ElsensohnEmmanuel BachyLaure LebrasBertrand FavierNicolas VantardDana GhergusCamille GolfierPierre SesquesAnne LazarethHélène LequeuEmmanuelle FerrantGilles SallesEmmanuelle Nicolas-VirelizierHervé Ghesquières
• Organismes : Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Centre Léon Bérard [Lyon] UNICANCER Centre Hospitalier Lyon Sud [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Université Claude Bernard Lyon 1 Immuno-Biologie des Lymphomes [CIRI] Centre Léon Bérard [Lyon] Groupe de Recherche et d’Étude du Processus Inflammatoire Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL] Immunologie, Immunopathologie et Chimie Thérapeutique Immunopathologie et chimie thérapeutique Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] French Innovative Leukemia Organization Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Hospices Civils de Lyon Université de Lyon Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Immuno-Biologie des Lymphomes [CIRI] Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL]
• Publié dans Leukemia & lymphoma le 27/10/2020

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 29/10/2021
• Auteurs : Michel AractingiPierre-Alexandre LeziartThomas FlayolsJulien PerezTomi SilanderPhilippe Souères
• Organismes : Naver Labs Europe [Meylan] Équipe Mouvement des Systèmes Anthropomorphes Équipe Mouvement des Systèmes Anthropomorphes Équipe Mouvement des Systèmes Anthropomorphes Naver Labs Europe [Meylan] Naver Labs Europe [Meylan] Équipe Mouvement des Systèmes Anthropomorphes

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Résumé : Predefined gait patterns for quadruped locomotion can hardly be optimal in all situations with regard to stability, cost of transport and velocity tracking error. Hence, in this work, we tackle the challenge of adapting a predefined trotting gait, implemented in the model-based controller of Solo, to optimize both energy consumption and velocity tracking. To this end, we propose a model-free reinforcement learning method for adapting the timings of the contact/swing phases for each foot. The learned agent augments a control pipeline that was previously developed for the Solo robot. We also propose to use a self-attention mechanism over the history of states in order to extract useful information for adapting the gait. Through a comprehensive set of experiments, we demonstrate how, compared to the nominal gait, our method significantly reduces energy consumption, better tracks the desired velocity, and makes it possible to reach higher speeds. A video of the method is found at https://youtu.be/ykbDUyASXs4.

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Fichiers liés : ICRA2022(5).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/10/2021
• Auteurs : Emmanuel Happi NgankouBenjamin GoryGaultier MarnatSébastien RichardRomain BourcierIgor SibonCyril DargazanliCaroline ArquizanBenjamin MaïerRaphaël BlancBertrand LapergueArturo ConsoliStéphane VannierLaurent SpelleChristian DenierMarion BoulangerMaxime GaubertiSuzana SalemeFrancisco MacianFrédéric ClarençonCharlotte RossoOlivier NaggaraGeorgios TsivgoulisOzlem Ozkul-WermesterChrysanthi PapagiannakiAlain ViguierChristophe CognardAnthony LebrasSarah EvainValérie WolffRaoul PopSerge TimsitJean Christophe GentricFrédéric BourdainLouis VeunacFrançois EugèneStephanos Nikolaos FinitsisMichel P. PiotinHocine RedjemSimon EscalardJean Philippe DessillesFrançois DelvoyeStanislas SmajdaHebert SolèneMikaël MazighiMikael ObadiaCandice SabbenPierre SenersIgor RaynouardOvide CorabianuThomas de BrouckerEric ManchonGuillaume TaylorMalek Ben MaachaLaurie Anne ThionAugustin LeclerJulien SavatovsjyFoch HospitalAdrien WangSerge EvrardMaya TchikviladzeNadia AjiliDavid WeisenburgerlileLucas GorzaGéraldine BuardOguzhan CoskunFederico Di MariaGeorges RodeshSergio ZimatoreMorgan LeguenJulie GratieuxFernando PicoHaja RakotoharinandrasanaPhilippe TassanRoxanna PollSylvie MarinierFlorent GarielXavier BarreauJérôme BergePatrice MenegonLudovic LucasStéphane OlindoPauline RenouSharmila SagnierMathilde PoliSabrina DebruxellesFrançois RouanetThomas TourdiasJean Sebastien LiegeyPierre BriauNicolas PangonLili DetrazBenjamin Daumas-DuportPierre Louis AlexandreMonica RoyCédric LenobleHubert Armand DesalBenoît GuillonSolène de GaalonCécile PreterreSerge BracardRené AnxionnatMarc BraunAnne Laure DerelleTonnelet RomainLiang LiaoFrançois ZhuEmmanuelle SchmittSophie PlanelLisa HumbertjeanGioia MioneJean Christophe LacourNolwenn Riou-ComteGérard AudibertMarcela VoicuLionel AlbMarie ReitterMadalina BrezeanuAgnès MassonAdriana TabarnaIona PodarSarah GuyFatiha BechiriPauline BourstFrancisco Macian-MontoroSuzanna SalemeCharbel MounayerAymeric RouchaudLaetitia GimenezAlexandre CosnardVincent CostalatGrégory GascouPierre Henri LefèvreImad DerrazCarlos RiquelmeNicolas GaillardIsabelle MourandLucas CortiFederico CagnazzoAdrien ter SchiphorstJean-Christophe FerréHélène RaoultThomas RonziereMaria LassaleChristophe PayaJean Yves GauvritClément TracolSophie Langnier-LemercierAxelle MauriceSabrina CochennecMélanie PinaultEimad ShotarNader Antoine SourourStéphanie LenckKévin PrematYves Samson Anne LégerSophie CrozierFlore BaronnetSonia AlamowitchLaure BottinMarion YgerVincent DegosOlivier ChassinVanessa ChalumeauJildaz CaroffLaura VendittiMariana SarovNicolas LegrisOlivier NaggaraWagih Ben HassenGrégoire BoulouisChristine Rodriguez-RégentDenis TrystramBasile KerlerouxValérie DomigoCatherine LamyJulia BirchenallClothilde IsabelFrançois LunChristophe CognardAnne Christine JanuelJean Marc OlivotLouis FontaineNicolas RaposoFabrice BonnevilleJean-François AlbucherLionel CalviereJean DarcourtGuillaume BellangerPhilippe TallEmmanuel TouzéCharlotte BarbierRomain SchneckenburgerJulien CogezSophie GuettierJulien OgnardFrançois Mathias MerrienOzlem Ozku WermesterEvelyne Guégan MassardierAude Bagan TriquenotMargeaux LefebvrePatricia BernadyLaurent Lagoarde-SegotHélène CailliezDavid HigueVéronique QuenardelleValérie LauerRoxana GheocaIrène Nora Pierre-PaulRemy BeaujeuxDan MihocMonica ManisorJulien PottecherAlain MeyerThiên-Nga Chamaraux-TranAnthony Le BrasArnaud Le Guen
• Organismes : Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Centre Hospitalier Universitaire de Bordeaux Service de neurologie [CHRU Nancy] Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Bordeaux Neuroradiologie [Hôpital Gui de Chauliac] Hôpital Gui de Chauliac [CHU Montpellier] CHU Rothschild [AP-HP] CHU Rothschild [AP-HP] Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch] UFR Sciences de la santé Simone Veil Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch] UFR Sciences de la santé Simone Veil Service de Neurologie [CHU Rennes] Service de Neuroradiologie [CHU de Bicêtre] Service de neurologie [Le Kremlin Bicêtre] Service de Neurologie [CHU Caen] Départment de Neuroradiologie [CHU Caen] Service de Neuroradiologie interventionnelle [CHU Limoges] Service de Neurologie [CHU Limoges] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service de Neurologie [CH Saint-Anne] Service de Neurologie [CH Saint-Anne] Service de neurologie [Rouen] Département de Neuroradiologie [CHU Rouen] Département Neurologie [CHU Toulouse] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Service de radiologie [Vannes] Service de radiologie [Vannes] Service de Neurologie [Strasbourg] Département de Neuroradiologie [Strasbourg] Service de Neurologie [Brest] Service de Neuroradiologie [Brest] Neurologie - Côte Basque Neurologie - Côte Basque Service de Neurologie [CHU Rennes] Aristotle University of Thessaloniki Neuroimagerie: méthodes et applications
• Publié dans Stroke le 31/10/2020

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Résumé : BACKGROUND AND PURPOSE: Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated the incidence, risk factors, and clinical implications of thrombectomy complications in daily clinical practice. METHODS: We used data from the ongoing prospective multicenter observational Endovascular Treatment in Ischemic Stroke Registry in France. The present study is a retrospective analysis of 4029 stroke patients with anterior large vessel occlusions treated with thrombectomy between January 2015 and May 2020 in 18 centers. We systematically collected procedural data, incidence of embolic complications, perforations and dissections, clinical outcome at 90 days, and hemorrhagic complications. RESULTS: Procedural complications occurred in 7.99% (95% CI, 7.17%–8.87%), and embolus to a new territory (ENT) was the most frequent (5.2%). Predictors of ENTs were terminal carotid/tandem occlusion (odds ratio [OR], 5 [95% CI, 2.03–12.31]; P<0.001) and an increased total number of passes (OR, 1.22 [95% CI, 1.05–1.41]; P=0.006). ENTs were associated to worse clinical outcomes (90-day modified Rankin Scale score, 0–2; adjusted OR, 0.4 [95% CI, 0.25–0.63]; P<0.001), increased mortality (adjusted OR, 1.74 [95% CI, 1.2–2.53]; P<0.001), and symptomatic intracerebral hemorrhage (adjusted OR, 1.87 [95% CI, 1.15–3.03]; P=0.011). Perforations occurred in 1.69% (95% CI, 1.31%–2.13%). Predictors of perforations were terminal carotid/tandem occlusions (39.7% versus 27.6%; P=0.028). 40.7% of patients died at 90 days, and the overall rate of poor outcome was 74.6% in case of perforation. Dissections occurred in 1.46% (95% CI, 1.11%–1.88%) and were more common in younger patients (median age, 64.2 versus 70.2 years; P=0.002). Dissections did not affect the clinical outcome at 90 days. Besides dissection, complications were independent of the thrombectomy technique. CONCLUSIONS: Thrombectomy complication rate is not negligible, and ENTs were the most frequent. ENTs and perforations were associated with disability and mortality, and terminal carotid/tandem occlusions were a risk factor.

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• Type de publi. :
• Date de publi. : 28/10/2021
• Auteurs : Louise TarradeJean-Pierre ChevrotJean-Philippe Magué
• Organismes : Interactions, Corpus, Apprentissages, Représentations LInguistique et DIdactique des Langues Étrangères et Maternelles Interactions, Corpus, Apprentissages, Représentations Institut Rhône-Alpin des systèmes complexes

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Résumé : The diffusion process of linguistic innovations has long been a topic of interest in sociolinguistics (Weinreich et al., 1968) and many studies have highlighted the influence of social structures on change (Labov, 2001; Milroy & Milroy, 1997). The recent access to massive social network data and the advent of computational sociolinguistics (Nguyen et al., 2016) allow an approach to this phenomenon that combines a large amount of data and a fine-grained temporality. Using methods from both computational sociolinguistics and network science, we focus on the diffusion of lexical innovations and we ask what differentiates, after an expansion phase, those that stabilize within our observation period from those that are eventually abandoned. In particular, we examine the impact of the social structure of linguistic communities on these diffusion and acceptance processes. We rely on a corpus of French tweets, that spans from 2012 to 2019 and includes about 600 million tweets from more than two million users. Based on the evolution over time of the rate of use of each linguistic form, we select those that appear during the period covered by the corpus and then we distinguish the forms that stabilize from those that eventually die out. By modeling the trajectories, we then identify the three characteristic periods of the diffusion of an innovation (Fagyal et al., 2010). Finally, by establishing the network of contact between users on the basis of their followers and followees, we examine the circulation of forms between them at different periods, and identify factors that condition the stabilization or not of innovations. This poster will present the methodologies used to identify linguistic innovations and to model their trajectory. We will also present the first results on the connection between the evolution of forms and the structure of the contact network.

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