Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 06/05/2025
• Auteurs : Yves ChalandonRaynier DevillierAriane BoumendilStéphanie NguyenClaude-Eric BulaboisPatrice CeballosEolia BrissotMarie-Thérèse RubioHélène Labussière-WalletJohan MaertensPatrice ChevallierNatacha MaillardXavier PoiréCristina Castilla-LlorenteYves BeguinJérôme CornillonSébastien MauryTony MarchandEtienne DaguindauJacques-Olivier BayPascal TurlureMagalie JorisAnne-Lise MenardKarin BilgerGaelle GuillermSylvie FrançoisAli BazarbachiSylvain ChantepiePhilippe LewalleAmbroise MarçaisMichael LoschiMalek BenakliPaul ChauvetEdouard ForcadeAnne HuynhMarie RobinStavroula Masouridi-Levrat
• Organismes : Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Centre de Recherche en Cancérologie de Marseille Société Francophone de Greffe de Moëlle et de Thérapie Cellulaire = French-speaking Society for Bone Marrow Transplantation and Cell Therapy CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Saint Eloi [CHU Montpellier] Centre de Recherche Saint-Antoine Service d'Hématologie [CHRU Nancy] Centre Hospitalier Lyon Sud [CHU - HCL] Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Cliniques universitaires St Luc [Bruxelles] Institut Gustave Roussy Centre Hospitalier Universitaire de Liège Institut de Cancérologie et d'Hématologie Universitaire de Saint-Étienne [CHU Saint-Etienne] CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer Centre Hospitalier Régional Universitaire de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service Hématologie Biologique [CHU Clermont-Ferrand] Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges] CHU Amiens-Picardie Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Laboratoire de Génétique Moléculaire [CHRU Strasbourg] Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Universitaire d'Angers American University of Beirut CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Universitaire de Bruxelles M3C-Necker, Hôpital universitaire Necker-Enfants malades, Université de Paris, Paris, France Centre Hospitalier Universitaire de Nice Centre Pierre et Marie Curie [Alger, Algeria] Pole Cardio-vasculaire et pulmonaire [CHU Lille] Centre Hospitalier Universitaire de Bordeaux Service Hématologie - IUCT-Oncopole [CHU Toulouse] Hopital Saint-Louis [AP-HP] Geneva University Hospitals and Geneva University
• Publié dans American Journal of Hematology le 26/10/2020

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Résumé : ABSTRACT There are very limited data regarding the outcomes of elderly patients with acute lymphoblastic leukemia (ALL) who undergo allogeneic hematopoietic stem cell transplantation (alloHSCT). A total of 316 ALL patients aged ≥ 60 years who underwent alloHSCT between 2010 to 2022 were identified in the SFGM‐TC registry. The primary objective was to evaluate progression‐free survival (PFS), non‐relapse mortality (NRM), relapse incidence (RI), and graft‐versus‐host disease (GvHD)‐free relapse‐free survival (GRFS), as well as their risk factors. The median age was 63.8 years (range 60–75.8), 49.8% of patients had Philadelphia‐positive B‐ALL (Ph + ALL), and 70.9% were in first complete remission (CR1) at transplantation. The donor was an unrelated donor in 52.1%, a matched related donor (MRD) in 26.3%, and a haplo‐identical donor in 17.7%. Reduced‐intensity conditioning (RIC) was administered to 64.6% of patients, while total body irradiation (TBI) was used in 35.8%. The 3‐year overall survival (OS) was 46% (95% CI 40%–53%). The 3‐year PFS, NRM, RI, and GRFS were 41% (95% CI 35%–48%), 23% (95% CI 18%–28%), 36% (95% CI 31%–42%), and 30% (95% CI 25%–37%), respectively. Multivariable analyses confirmed poorer OS and PFS in patients with advanced disease, with an HR of 1.79 (95% CI 1.22–2.64), p = 0.0032. Additionally, the ALL subtype significantly impacted outcomes, with an HR of 1.99 (95% CI 1.42–2.79) for non‐Ph + ALL. This study suggests that alloHSCT is a viable option for elderly ALL patients, as age itself did not impact outcomes. However, advanced disease and non‐Ph + ALL were associated with significantly worse survival.

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Fichiers liés : Chalandon - 2025 - Allogeneic Hematopoietic Stem Cell Transplantation for Elderly Acute Lymphoblastic Leukemia Patients _SFGM-TC elderly ALL alloHSCT paper revision 020325 unmarked version.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 06/05/2025
• Auteurs : Vladimir ChekhovskyAram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerSuman ChatterjeeKonstantinos DamanakisMarko DragicevicPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonThomas van LaerPierre van MechelenNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongSteven LowetteInna MakarenkoDenise MüllerStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoClaudio CaputoJerome de Favereau de JeneretChristophe DelaereIzzeddin Suat DonertasAndrea GiammancoAhmet Oguz GuzelSandhya JainVincent LemaitreJindrich LidrychPaola MastrapasquaTu Thong TranSemra TurkcaparGilvan AlvesEduardo CoelhoGilson Correia SilvaCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorMapse Barroso Ferreira FilhoHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaTulio Laux KuhnMatheus MacedoJordan MartinsKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielCesar Augusto BernardesLuigi CalligarisThiago TomeiEduardo de Moraes GregoresIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevRoumyana HadjiiskaPlamen IaydjievMilena MishevaMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovElton ShumkaSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurTongguang ChengTahir JavaidLi YuanZhen HuZhengchen LiangJinfeng LiuGuo-Ming ChenHe-Sheng ChenMingshui ChenFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoZhenan LiuRamkrishna SharmaJia-Ning SongJunquan TaoChu WangJin WangZebing WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinXiaohu SunDayong WangHeng YangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerBolin LiHui WangKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge 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MallampalliAbdollah MohammadiSusmita MondalGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiAlexander ErshovIgor GolutvinIlya GorbunovVladimir KarjavineVyacheslav KlyukhinOlga KodolovaVladimir KorenkovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaVitaly SmirnovOleg TeryaevAlexander ToropinNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinGenady GavrilovVictor GolovtcovYury IvanovVictor KimVictor MurzinVadim OreshkinDmitry SosnovValentin SulimovLev UvarovAlexey VorobyevAlexander DermenevSergei GninenkoNikolai GolubevAnton KarneyeuDmitrii KirpichnikovMikhail KirsanovNikolai KrasnikovIrina TlisovaKirill IvanovVladimir GavrilovNatalia LychkovskayaVladimir PopovAlexander ZhokinRuslan ChistovMikhail DanilovSergey PolikarpovVladimir AndreevMaksim AzarkinMartin KirakosyanAdel TerkulovEdouard BoosViacheslav BunichevMikhail DubininLev DudkoMaxim PerfilovViktor SavrinGeorge VorotnikovVladimir BlinovTatyana DimovaAleksei KozyrevOlesia RadchenkoYuri SkovpenVassili KachanovSergei SlabospitskiiAndrey UzunianAnton BabaevVladislav BorshchDmitry Druzhkin
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Laboratoire d'Annecy de Physique des Particules

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Résumé : Precision measurements of Higgs boson differential production cross sections are a key tool to probe the properties of the Higgs boson and test the standard model. New physics can affect both Higgs boson production and decay, leading to deviations from the distributions that are expected in the standard model. In this paper, combined measurements of differential spectra in a fiducial region matching the experimental selections are performed, based on analyses of four Higgs boson decay channels ($\gamma\gamma$, ZZ$^{(*)}$, WW$^{(*)}$, and $\tau\tau$) using proton-proton collision data recorded with the CMS detector at $\sqrt{s}$ = 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$. The differential measurements are extrapolated to the full phase space and combined to provide the differential spectra. A measurement of the total Higgs boson production cross section is also performed using the $\gamma\gamma$ and ZZ decay channels, with a result of 53.4$^{+2.9}_{-2.9}$ (stat)$^{+1.9}_{-1.8}$ (syst) pb, consistent with the standard model prediction of 55.6 $\pm$ 2.5 pb. The fiducial measurements are used to compute limits on Higgs boson couplings using the $\kappa$-framework and the SM effective field theory.

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• Type de publi. : Article dans une revue
• Date de publi. : 06/05/2025
• Auteurs : Adrien VigneronLilian CloarecCéline Brochier-ArmanetJean Pierre FlandroisMarc TroussellierCécile BernardHélène AgoguéPhilippe OgerMylène Hugoni
• Organismes : Microbiologie, adaptation et pathogénie Microbiologie, adaptation et pathogénie Microbiologie des Environnements Extrêmes = Microbiology of Extreme Environments Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 MARine Biodiversity Exploitation and Conservation - MARBEC Molécules de Communication et Adaptation des Micro-organismes LIttoral ENvironnement et Sociétés Microbiologie des Environnements Extrêmes = Microbiology of Extreme Environments Microbiologie, adaptation et pathogénie Microbiologie, adaptation et pathogénie Institut universitaire de France Microbiologie des Environnements Extrêmes = Microbiology of Extreme Environments
• Publié dans Environmental Microbiome le 28/05/2020

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Résumé : Abstract Background Extreme environments are useful systems to investigate limits of life, microbial biogeography and ecology, and the adaptation and evolution of microbial lineages. Many novel microbial lineages have been discovered in extreme environments, especially from the Planctomycetota–Verrucomicrobiota–Chlamydiota (PVC) superphyla. However, their evolutionary history and roles in ecosystem functioning and microbiome assemblage are poorly understood. Results Applying a genome-centric approach on an 8-year metagenomic timeseries produced from the hypersaline and hyperalkaline waters of Lake Dziani Dzaha (Mayotte), we recovered 5 novel PVC extremophilic candidate lineages from the biosphere of the lake. Sibling to Elusimicrobia and Omnitrophota, these lineages represented novel halophilic clades, with global distributions bounded to soda lakes and hypersaline hydrosystems. Genome mining of these newly defined clades revealed contrasted, but ecologically relevant, catabolic capabilities involved in the carbon, hydrogen and iron/electron cycles of the Dziani Dzaha ecosystem. This also includes extracellular electron transfer for two of them, suggesting metal reduction or potential electron exchanges with other members of the lake community. By contrast, a putative extracellular giant protein with multiple carbohydrate binding domains and toxin-like structures, as observed in virulence factors, was identified in the genome of another of these clades, suggesting predatory capabilities. Conclusions Our results provided genomic evidences for original metabolism in novel extremophile lineages of the PVC superphyla, revealing unforeseen implications for members of this widespread and diverse bacterial radiation in aquatic saline ecosystems. Finally, monitoring the in-situ distribution of these lineages through the timeseries reveals the drastic effects of environmental perturbations on extreme ecosystem biodiversity.

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Fichiers liés : s40793-025-00699-1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 05/05/2025
• Auteurs : Daniel ThirionJean-Marc DaveauV. EgloffDavid HelyVincent BeroullePhilippe Roche
• Organismes : STMicroelectronics [Crolles] Laboratoire de Conception et d'Intégration des Systèmes STMicroelectronics [Crolles] Laboratoire de Conception et d'Intégration des Systèmes Laboratoire de Conception et d'Intégration des Systèmes Conception et Test de SYStèmes embarqués Laboratoire de Conception et d'Intégration des Systèmes Conception et Test de SYStèmes embarqués STMicroelectronics [Crolles]

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Résumé : With the increase in cybersecurity requirements and the growing connectivity of critical systems like vehicles and satellites, implementing both functional safety and hardware security is crucial. Although safety and security methods are well studied, combined analysis at the RTL or Netlist level remains under-explored. This paper provides an initial analysis of multiple AES designs—one unprotected, one with a safety-oriented countermeasure (Lockstep), and one with security-oriented countermeasures (Parity-Predictor)—using both simulation and formal methods. We identify the challenges and opportunities for enhancing combined safety and security assessments. Additionally, we evaluate the AES designs against ISO 26262 safety metrics and analyze their resilience to laser attacks, offering insight into their security robustness.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2025
• Auteurs : Chloé GrolleauMaxime BattistellaEve ZakineThomas PoisotFlorence CordolianiThibault MahevasMarie JachietAdèle de MassonArsène MekinianBenjamin TerrierSophie Georgin LaviallePierre FenauxLionel AdèsLin-Pierre ZhaoKevin SerrorMatthieu DuchmannEmmanuelle ClappierRachel OnifarasoaniainaHelene Le BuanecPhilippe MogueletJean-David BouazizFrancois Chasset
• Organismes : Immunologie humaine, physiopathologie & immunothérapie Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de pathologie [Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] CHU Saint-Antoine [AP-HP] Université Paris Cité Centre national de référence pour les maladies auto-immunes systémiques rares [CHU Cochin] Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] Maladies génétiques d'expression pédiatrique CHU Tenon [AP-HP] Service d'Hématologie Seniors - Hôpital Saint-Louis Service d'Hématologie Seniors - Hôpital Saint-Louis Service d'Hématologie Seniors - Hôpital Saint-Louis Service de chirurgie plastique et reconstructive [Hôpital Saint Louis] Génomes, biologie cellulaire et thérapeutiques Service Hématologie Transplantation [Hôpital Saint Louis, AP-HP] Génomes, biologie cellulaire et thérapeutiques Service Hématologie Transplantation [Hôpital Saint Louis, AP-HP] Institut Cochin Immunologie humaine, physiopathologie & immunothérapie CHU Tenon [AP-HP] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie CHU Tenon [AP-HP] Centre d'Immunologie et des Maladies Infectieuses
• Publié dans JAMA Dermatology le 28/10/2020

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Résumé : Importance VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease caused by UBA1 somatic variants in hematopoietic progenitor cells, mostly involving adult men. It is associated with inflammatory-related symptoms, frequently involving the skin and hematological disorders. Recently described myelodysplasia cutis (MDS-cutis) is a cutaneous manifestation of myelodysplasia in which clonal myelodysplastic cells infiltrate the skin. In both cases, skin lesions are driven by the infiltration of clonal mutated myeloid cells and may clinically and histologically mimic Sweet syndrome (SS), a neutrophilic skin disease. Objective To decipher the underlying mechanisms driving these 3 myeloid-related skin diseases (ie, VEXAS, MDS-cutis, and SS) compared with leukemia cutis (LC), a neoplastic blastic myeloid-related skin condition, and healthy control skin samples. Design, Setting, and Participants This multicenter translational study on formaldehyde-fixed paraffin-embedded lesional skin samples of VEXAS syndrome, MDS-cutis, idiopathic SS, LC, and healthy controls using bulk RNA sequencing analyses was conducted in France. Patients included had cutaneous lesions of VEXAS syndrome, MDS-cutis, idiopathic SS, or LC. The data were analyzed from June 2023 to March 2024. Main Outcomes and Measures Differentially expressed genes between conditions were studied. These genes were used to characterize the enrichment in activated inflammatory pathways in each condition using Gene Set Enrichment Analysis and Ingenuity Pathway Analysis. Results Twenty patients with skin conditions (median [range] age, 67 [43-88] years; 10 [50%] men) were included. Six had cutaneous lesions of VEXAS syndrome, 4 had MDS-cutis, 5 had idiopathic SS, and 5 had LC. They were compared with 5 healthy control skin samples. Bulk RNA sequencing analysis reveals that MDS-cutis and VEXAS syndrome lesions display closely related transcriptomic profiles, highly imprinted by cytokine responses, interferon signatures, and activation of the apoptosis pathway. A shared inflammatory environment between MDS-cutis, VEXAS syndrome, and idiopathic SS was observed, mostly relying on a type 1 immune response led by type 1 and 2 interferons, along with the activation of tumor necrosis factor and interleukin (IL)–1β pathways. Conversely, LC showed an isolated transcriptomic profile mainly enriched in cell cycle pathways. Conclusions and Relevance The findings of this translational study highlight a common inflammatory pattern shared between VEXAS syndrome, MDS-cutis, and refractory idiopathic SS skin samples. This suggests the potential therapeutic targeting of interferon pathways in patients affected with refractory nonblastic myeloid-related skin diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2025
• Auteurs : Chloé GrolleauMaxime BattistellaEve ZakineThomas PoisotFlorence CordolianiThibault MahevasMarie JachietAdèle de MassonArsène MekinianBenjamin TerrierSophie Georgin LaviallePierre FenauxLionel AdèsLin-Pierre ZhaoKevin SerrorMatthieu DuchmannEmmanuelle ClappierRachel OnifarasoaniainaHelene Le BuanecPhilippe MogueletJean-David BouazizFrancois Chasset
• Organismes : Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie Service de pathologie [Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] Hôpital Cochin [AP-HP] Université Paris Descartes - Paris 5 Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] Maladies génétiques d'expression pédiatrique Service d'Hématologie Seniors - Hôpital Saint-Louis Service d'Hématologie Seniors - Hôpital Saint-Louis Service d'Hématologie Seniors - Hôpital Saint-Louis Service de chirurgie plastique et reconstructive [Hôpital Saint Louis] Service Hématologie Transplantation [Hôpital Saint Louis, AP-HP] Génomes, biologie cellulaire et thérapeutiques Service Hématologie Transplantation [Hôpital Saint Louis, AP-HP] Génomes, biologie cellulaire et thérapeutiques Institut Cochin Immunologie humaine, physiopathologie & immunothérapie CHU Tenon [AP-HP] Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie CHU Tenon [AP-HP] Centre d'Immunologie et des Maladies Infectieuses
• Publié dans JAMA Dermatology le 28/10/2020

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Résumé : Importance VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease caused by UBA1 somatic variants in hematopoietic progenitor cells, mostly involving adult men. It is associated with inflammatory-related symptoms, frequently involving the skin and hematological disorders. Recently described myelodysplasia cutis (MDS-cutis) is a cutaneous manifestation of myelodysplasia in which clonal myelodysplastic cells infiltrate the skin. In both cases, skin lesions are driven by the infiltration of clonal mutated myeloid cells and may clinically and histologically mimic Sweet syndrome (SS), a neutrophilic skin disease. Objective To decipher the underlying mechanisms driving these 3 myeloid-related skin diseases (ie, VEXAS, MDS-cutis, and SS) compared with leukemia cutis (LC), a neoplastic blastic myeloid-related skin condition, and healthy control skin samples. Design, Setting, and Participants This multicenter translational study on formaldehyde-fixed paraffin-embedded lesional skin samples of VEXAS syndrome, MDS-cutis, idiopathic SS, LC, and healthy controls using bulk RNA sequencing analyses was conducted in France. Patients included had cutaneous lesions of VEXAS syndrome, MDS-cutis, idiopathic SS, or LC. The data were analyzed from June 2023 to March 2024. Main Outcomes and Measures Differentially expressed genes between conditions were studied. These genes were used to characterize the enrichment in activated inflammatory pathways in each condition using Gene Set Enrichment Analysis and Ingenuity Pathway Analysis. Results Twenty patients with skin conditions (median [range] age, 67 [43-88] years; 10 [50%] men) were included. Six had cutaneous lesions of VEXAS syndrome, 4 had MDS-cutis, 5 had idiopathic SS, and 5 had LC. They were compared with 5 healthy control skin samples. Bulk RNA sequencing analysis reveals that MDS-cutis and VEXAS syndrome lesions display closely related transcriptomic profiles, highly imprinted by cytokine responses, interferon signatures, and activation of the apoptosis pathway. A shared inflammatory environment between MDS-cutis, VEXAS syndrome, and idiopathic SS was observed, mostly relying on a type 1 immune response led by type 1 and 2 interferons, along with the activation of tumor necrosis factor and interleukin (IL)–1β pathways. Conversely, LC showed an isolated transcriptomic profile mainly enriched in cell cycle pathways. Conclusions and Relevance The findings of this translational study highlight a common inflammatory pattern shared between VEXAS syndrome, MDS-cutis, and refractory idiopathic SS skin samples. This suggests the potential therapeutic targeting of interferon pathways in patients affected with refractory nonblastic myeloid-related skin diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2025
• Auteurs : Kien Vu TrungEinas Abou-AliAiste GullaKevin SoaresFabrice CaillolWoo PaikBertrand NapoleonAsif HalimiViliam MasarykMarco BrunoEnrique Pérez-Cuadrado-RoblesLouisa BolmSteffen SeyfriedMaria PetroneBengisu YilmazCharles VollmerArthur BergerLaura MagginoPeter SchemmerDörte WichmannElias KaramAna DugicLumir KunovskySara RegnerSebastien GaujouxMarcus HollenbachChristian HeiseFrancesco AuriemmaGalen LeungMark SchattnerWilliam JarnaginTiegong WangMarc GiovanniniJean Philippe RatoneAlessandro ZerbiGennaro NappoUrban ArneloErik HaraldssonAlexander WaldthalerUwe WillRita SaadehSophia van der WielPierre DeprezAlain SauvanetTobias KeckFrancois SoucheJean FabreNicolas MusquerGeorg KählerAlberto MarianiPiera ZaccariGiulio BelfioriMassimo FalconiStefano PartelliIhsan Ekin DemirGüralp CeyhanJean-Marc RégimbeauJohan GagniéreAlessandro RepiciAndrea AnderloniFabio CascianiMarco del ChiaroAtsushi ObaRichard SchulickRoberto SalviaAna LaranjoDiogo LibanioMadaline IlieJohanna LaukkarinenAlbrecht HoffmeisterJonas RosendahlBrigitte SchumacherLouise BarbierEphrem SalaméArnaud AlvesNicolas RegenetSteffen MuehldorferStéphanie TruantKarel CacaMarcel TantauDavid BirnbaumJens WernerKestutis StrupasEdris WediKatrin SalzmannMatthieu BruzziRenato-Micelli LupinacciPatrice DavidLilian SchwarzArthur SchmidtTullio PiardiMartin BrunelJean-Christoph VaillantCharles de PonthaudCeline LejeuneRaffaele BrustiaRim CherifPaul-Noet DumontFrederic PratMatthias LöhrBenjamin MeierBogdan MiutescuRainer Christoph MikschYosuke InoueMario Dinis-RibeiroTobias KleemannVasile SandruReea AholaDavid AlbersTiago GonçalvesTobias WeismüllerDominik HelingThilo HackertStefano CrippaMoritz SchiemerSohei SatoiPatrick MichlSebastian Krug
• Organismes : Centre for Wireless Communications [University of Oulu] Vilnius University [Vilnius] Memorial Sloan Kettering Cancer Center Institut Paoli-Calmettes Hôpital privé Jean Mermoz [Lyon] Department of Gastroenterology and Hepatology Hôpital Européen Georges Pompidou [APHP] Kaunas University of Technology Centre Hospitalier Universitaire d'Angers Heidelberg University Hospital [Heidelberg] Chirurgie digestive [CHU Amiens] Simplification des soins chez les patients complexes - UR UPJV 7518
• Publié dans Gastrointestinal Endoscopy le 25/10/2020

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Résumé : Background and study aims: Endoscopic papillectomy (EP) is the standard treatment for non-invasive ampullary lesions (AL), while advanced cases require surgery. Managing AL is challenging and may lead to over- or undertreatment. We developed a score to identify the best candidates for endoscopic or surgical treatment. Patients and methods: We analyzed 447 patients who underwent EP. The cohort was randomly split into a training (n=325) and validation set (n=122). Logistic regression identified predictors for incomplete resection (R1), which were incorporated into a four-item score. Performance was assessed using AUROC. Results: Independent predictors for R1 included size≥30mm(S), high-grade dysplasia/invasive cancer(D), laterally-spreading-lesion(L), and bile/pancreatic duct dilation(D). AL with 0-1 points had the highest R0 rates (training: 86.0%; validation: 88.5%), while ≥2 points significantly increased R1 rates (training: 52.0%; validation: 57.7%; p<0.001). AUROC was 0.792 (training) and 0.708 (validation). Conclusion: The SDLD score predicts incomplete resection in EP and aids treatment decisions.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2025
• Auteurs : Romain ManetHugues de CoursonCyrille CapelChristophe JoubertNathalie ChivoretMatthieu FaillotBaptiste BalancaAlexandre Bani-SadrMickael CardinaleAndres CocaFrançois CottonPierre EsnaultClémentine GalletSébastien GazzolaStéphane GoutagnyVincent JeckoMarion Le MarechalJacques LuautéGuillaume MortametJean-Denis MoyerHervé QuintardAlice RollandÉdouard SamarutStéphanie SigautEric VerinMathieu VinchonPhilippe DecqJean-François PayenArnaud Dagain
• Organismes : Hospices Civils de Lyon Bordeaux population health CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Hopital d'instruction des armées Sainte-Anne [Toulon] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Université Claude Bernard Lyon 1 Hospices Civils de Lyon Translational and Integrative Group in Epilepsy Research Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Hopital d'instruction des armées Sainte-Anne [Toulon] Centre Hospitalier Universitaire [Strasbourg] Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Hopital d'instruction des armées Sainte-Anne [Toulon] Hospices Civils de Lyon Hôpital Beaujon [AP-HP] Optimisation thérapeutique en Neuropsychopharmacologie Hôpital de la Timone [CHU - APHM] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Biostatistique et technologies de l'information et de la communication (BioSTIC) - [Hôpital de la Timone - APHM] Hôpital Pellegrin Centre Hospitalier Universitaire [CHU Grenoble] Médecine Physique et Réadaptation [Hôpital Henry Gabrielle - Lyon] Evaluating, understanding, supporting motor, perceptive and social Trajectories Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Beaujon [AP-HP] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers
• Publié dans Neurochirurgie le 22/10/2020

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Résumé : Objective To develop a multidisciplinary French framework addressing neurosurgical management in the initial phase of traumatic brain injury (TBI) in adults and children. Design A panel of 29 experts was formed at the request of the French Society of Neurosurgery (SFNC), with the participation of the French Society of Pediatric Neurosurgery (SFNCP), French Society of Private-Practice Neurosurgeons (SFNCL), French-Speaking Neurocritical Care and Neuro-Anesthesiology Society (ANARLF), French Society of Anesthesia, Critical Care and Perioperative Medicine (SFAR), French-Speaking Pediatric Emergency and Intensive Care Group (GFRUP), French Society of Neuroradiology (SFNR), French-Speaking Infectious Diseases Society (SPILF), and the French Society of Physical Medicine and Rehabilitation (SOFMER). Methods Questions were formulated using the PICO (Patients, Intervention, Comparison, Outcome) format, grouped into 7 categories: 1. Factors of poor prognosis, 2. Extradural hematoma, 3. Acute subdural hematoma, 4. Skull-base fracture and dural tear, 5. Penetrating traumatic brain injury, 6. Post-traumatic cerebrospinal fluid disorder, and 7. Pediatric specificities. Results Synthesis by the experts and application of the GRADE® method resulted in the formulation of 45 recommendations. Strong consensus was reached for all recommendations at the first round of rating, Conclusion There was a strong consensus among the experts on important interdisciplinary recommendations to improve the neurosurgical management of patients with TBI.

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Fichiers liés : BPH_Neurochirurgie_2025_Manet.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2025
• Auteurs : Mikael CohenFabien RollotMarc DebouverieHélène ZephirSandra VukusicJérome de SezePierre LabaugeCassandre Landes-ChâteauLydiane MondotMichael LevrautAurélie RuetEric BergerDavid LaplaudJonathan CironBertrand BourreEmmanuelle Le PageCaroline PapeixEric ThouvenotAbdullatif Al KhedrBruno StankoffJean PelletierElisabeth MaillartOlivier CasezThibault MoreauGilles-Louis DeferPierre ClavelouPhilippe CabreSolène MoulinJean Philippe NeauMickael ZedetKarolina HankiewiczInès DoghriHaifa Ben NasrCorinne PottierLaurent MagyDalia Dimitri BoulosOlivier HeinzlefJean-Philippe CamdessanchéMarc CoustansChantal NifleDavid BrassatRomain CaseyChristine Lebrun‐frenay
• Organismes : Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hospices Civils de Lyon Université Claude Bernard Lyon 1 Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Service de neurologie [CHRU Nancy] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Université Claude Bernard Lyon 1 Fondation Eugène Devic EDMUS Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center CIC Strasbourg Hôpitaux Universitaires de Strasbourg Hôpital de Hautepierre [Strasbourg] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Centre Hospitalier Universitaire de Bordeaux Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Service de Neurologie [CHRU Besançon] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology CIC Plurithématique de Nantes Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires CHU Rouen Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle CHU Amiens-Picardie CHU Saint-Antoine [AP-HP] Hôpital de la Timone [CHU - APHM] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] Translational Research in Autoimmunity and Inflammation Group CHU Dijon Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Clermont-Ferrand Université Clermont Auvergne Hôpital Pierre Zobda-Quitman [CHU de la Martinique] Hôpital Maison Blanche Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Henri Mondor Centre Hospitalier Universitaire de La Réunion CHU Trousseau [Tours] Centre Hospitalier Sud Francilien hôpital NOVO Hôpital Dupuytren [CHU Limoges] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Intercommunal de Cornouaille Centre Hospitalier de Versailles André Mignot CHU Pitié-Salpêtrière [AP-HP] Université Claude Bernard Lyon 1 Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées
• Publié dans European Journal of Neurology le 22/10/2020

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Résumé : Background: Real-world data suggest that the early use of highly active therapies (HAT) may reduce the risk of transition to secondary progressive MS (SPMS). However, current knowledge about predictive factors of outcomes needs to be improved. The primary objective of this study was to determine factors associated with the occurrence of SPMS in patients treated early after MS onset with an HAT. Methods: Retrospective, multicentric study based on the French MS database. Patients who initiated a HAT within 5 years after MS onset, EDSS ⩽4, and had a follow-up >5 years were included. The association of each covariate at baseline with time to the occurrence of SPMS was quantified by hazard ratios (HRs) in unadjusted and adjusted Cox proportional hazards models. Results: Two thousand two hundred and thirty-seven patients were included in the analysis: mean age 31.6 years, female/male sex ratio 2.3, and median EDSS 2.0. The estimated probability of reaching SPMS, progression independent of relapse activity (PIRA) and progression independent of activity (PIA) at 10 years was 8%, 22%, and 11%, respectively. After adjustment, we found that female patients (HR 0.64, p = 0.036) had a lower risk of developing SPMS. Older age, EDSS >0 (HR 7.44, p < 0.001), and oral versus intravenous HAT (HR 1.97, p = 0.003) were significantly associated with an increased SPMS risk. Early PIRA and PIA predicted conversion to SPMS. Conclusions: Early HAT use resulted in a low risk of developing SPMS over 10 years. Introducing the HAT before any residual disability was associated with a lower risk of progression.

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Fichiers liés : Cohen et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2025
• Auteurs : Sylvain DiamantisT. FraisseEric BonnetVirginie PrendkiClaire AndréjakMarianne AuquierCarla Garcia CarmonaEric FarfourPierre FillatreSébastien GallienGaëtan GavazziAnne-Laure HouistJulie Lourtet-HascoëtMathilde PerrinEmilie PietStanislas RebaudetYves RollandJ.P. LanoixAlain Putot
• Organismes : Centre Hospitalier de Melun Centre Hospitalier Alès-Cévennes Pôle IUCT [CHU Toulouse] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Pneumologie [CHU Amiens] CHU Amiens-Picardie Centre Médical de Forcilles [Lesigny, France] Hôpital Foch [Suresnes] ESCMID [Basel] CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire [CHU Grenoble] Institut Informatique et Mathématiques Appliquées de Grenoble (IMAG) CHU Henri Mondor [Créteil] Groupe Hospitalier Paris Saint-Joseph Laboratoire Sols et Environnement Centre Hospitalier Sud Francilien Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Institut Hospitalier Universitaire HealthAge CHU Amiens-Picardie Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Université Bourgogne Europe
• Publié dans Infectious Diseases Now le 08/09/2022

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