Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Laëtitia LemrabetCécile LasserreMarie-Pierre DoinMarianne MétoisAnne ReplumazPhilippe-Hervé LeloupSun JianbaoMarie-Luce Chevalier
• Organismes : Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut des Sciences de la Terre Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut des Sciences de la Terre Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement

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Résumé : The use of high spatial and temporal resolution data is a key condition for characterizing interseismic deformation along major faults and understanding their roles in accommodating the deformation. Here we present an analysis using 4 years of Sentinel-1 InSAR data to characterize interseismic deformation along the Xianshuihe (XSH) fault system and the Kunlun (KUN) fault in the eastern edge of the Tibetan plateau. Thanks to the NSBAS automated processing chain (Doin et al., 2011, Grandin, 2015), implemented at the CNES high-performance computing center in Toulouse as part of the FLATSIM project (ForM@Ter LArge-scale multi-Temporal Sentinel-1 Interferometry processing chain in Muscate), we automatically perform high-resolution time series analysis of 2014-2019 Sentinel-1 InSAR data set, acquired along 1200 km-long ascending and descending orbits, over the study area. According to an elastic block model approach, InSAR times series are combined to the latest published GPS velocity field and inverted using the block modeling software TDEFNODE (McCaffrey., 2009) to model fault slip rates and coupling distribution along these two major strike-slip faults and identify asperities and potential creeping areas as well as analyze internal block deformation. Our models suggest the existence of a fault connecting the XSH fault and the KUN fault and accomodating part of the deformation at a constant slip rate of 10 mm/yr. It shows that the slip rate on the XSH fault system increases from west to east, from 5 mm/yr to 14 mm/yr between latitudes 34.3°N and 29.3°N, while the slip rate on the Kunlun fault slightly decreases from west to east from 10 mm/yr to 9 mm/yr. The slip deficit rate observed along the XSH fault system shows strong lateral variations, that we analyze with respect to the seismic history of the fault, and suggests the presence of shallow creep on the eastern part of the fault. The slip deficit rate observed along the Kunlun fault appears more homogeneous. However, we observe a strong deformation gradient that we interpret as a post-seismic signal at the eastern tip of the rupture of the 2001 Kokoxili earthquake and we analyze its temporal evolution.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Leny MontheilMélody PhilipponPhilippe MunchDouwe van HinsbergenJean-Jacques CorneePierre Camps
• Organismes : Géosciences Montpellier

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Mathilde BanjanChristian CrouzetPierre SabatierHervé JomardFrançois DemoryAnne-Lise DevelleJean-Philippe JennyErwan Messager
• Organismes : Université Savoie Mont Blanc Université Savoie Mont Blanc Université Savoie Mont Blanc Bureau d'évaluation des risques sismiques pour la sûreté des installations Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Université Savoie Mont Blanc Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Université Savoie Mont Blanc

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : J. KhodrPhilippe ZerbibMoshe RogosnitzkyL. MagroStéphanie TruantIbrahim Yakoub-AghaAlain DuhamelDavid Seguy
• Organismes : Lille Inflammation Research International Center - U 995 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Inflammation Research International Center - U 995 Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Lille Inflammation Research International Center - U 995
• Publié dans Annals of Surgery le 10/04/2024

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Résumé : Objective: The aim of this study was to evaluate the benefit of diverting enterostomy (DE) in patients with severe steroid-refractory (SR) gastrointestinal acute graft-versus-host-disease (GI-aGVHD) following allogeneic hematopoietic stem-cell transplantation (ASCT). Summary and Background Data: Severe GI-aGVHD refractory to the first-line steroid therapy is a rare but dramatic life-threatening complication. Second lines of immunosuppressors have limited effects and increase the risk of sepsis. Data suggest that limiting GI bacterial translocation by DE could restrain severe GI-aGVHD. Methods: From 2004 to 2018, we retrospectively reviewed all consecutive patients undergoing ASCT for hematologic malignancies who developed severe SR GI-aGVHD. We compared patients in whom a proximal DE was performed (Enterostomy group) with those not subjected to DE (Medical group). The primary endpoint was the 1-year overall survival (OS) measured from the onset of GI-aGVHD. Secondary endpoints were the 2-year OS and causes of death. Results: Of the 1295 patients who underwent ASCT, 51 patients with severe SR GI-aGVHD were analyzed (13 in Enterostomy group and 38 in Medical group). Characteristics of patients, transplantation modalities, and aGVHD severity were similar in both groups. The 1-year OS was better after DE (54% vs 5%, P = 0.0004). The 2-year OS was also better in “Enterostomy group” (31% vs 2.5%; P = 0.0015), with a trend to lower death by sepsis (30.8% vs 57.9%; P = 0.091). Conclusion: DE should be considered for severe GI-aGVHD as soon as resistance to the corticosteroid is identified.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Pierre ChauvelotCéline Dupieux-ChabertLélia AbadAubin SoucheTristan FerryJérôme JosseFrédéric LaurentFlorent ValourTristan FerryTristan FerryFlorent ValourThomas PerpointPatrick MiailhesFlorence AderSandrine RouxAgathe BeckerClaire Triffault-FillitAnne ConradCécile PouderouxNicolas BenechPierre ChauvelotPaul ChabertEvelyne BraunChristian ChidiacSébastien LustigElvire ServienCécile BataillerStanislas GunstAxel SchimdtMatthieu MalatrayEliott Sappey-MarinierFessy Michel-HenryAnthony VisteBesse Jean-LucPhilippe ChaudierLucie LouboutinQuentin OdeAdrien van HaeckeMarcelle MercierVincent BelgaidArnaud WalchSébastien MartresFranck TrouilletYannick HeeryCédric BarreyAli MojallalSophie BrossetCamille HanriatPhilippe Céruse PersonCarine FuchsmannClémentine DaveauJacques BlancArnaud GleizalMathieu DauradeJérôme BourletFrédéric AubrunMikhail DziadzkoCaroline MacabéoFrederic LaurentLaetitia BerautTiphaine Roussel-GaillardCéline Dupieux-ChabertCamille KolendaJérôme JosseFabien CraigheroLoic BousselJean-Baptiste PialatIsabelle MorelecMichel TodMarie-Claude GagnieuSylvain GoutelleEugénie Mabrut
• Organismes : Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI]
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Objectives Long-acting lipoglycopeptides are promising therapeutic options in Staphylococcus aureus bone and joint infections (BJIs). This study evaluated the ability of dalbavancin to eradicate the intraosteoblastic reservoir of S. aureus, associated with BJI chronicity. Methods Osteoblastic cells were infected with a standardized inoculum of the S. aureus reference strain HG001 and incubated for 24 h with dalbavancin, vancomycin or rifampicin using the MIC, 10×MIC, 100×MIC and/or the intraosseous concentrations reached using standard therapeutic doses (i.e. vancomycin, 10 mg/L; rifampicin, 2 mg/L; and dalbavancin, 6 mg/L). The remaining intracellular bacteria were quantified by plating cell lysates. Results MICs of dalbavancin, vancomycin and rifampicin were 0.125, 1 and 0.004 mg/L, respectively. Dalbavancin significantly reduced the intracellular inoculum of S. aureus starting at a concentration equal to the MIC, with a significant dose effect, ranging from a reduction of 31.4% (95% CI = 17.6%–45.2%) at MIC to 51.6% (95% CI = 39.8%–63.4%) at 100×MIC compared with untreated cells. Of note, dalbavancin was the only molecule to significantly reduce the intraosteoblastic inoculum at low concentration (MIC). At intraosseous concentrations, dalbavancin reduced the intracellular inoculum by 49.6% (95% CI = 45.1%–54.1%) compared with untreated cells (P < 0.001), with no significant difference compared with vancomycin (38.1%; 95% CI = 19.2%–57.0%; P = 0.646), and was less efficient than rifampicin (69.0%; 95% CI = 63.2-74.8; P < 0.001). Conclusions Dalbavancin was able to decrease the intraosteoblastic S. aureus inoculum by 50% at intraosseous concentrations reached during standard human therapeutic dosing, with no difference compared with vancomycin, and remained less efficient than rifampicin. However, it was the only molecule significantly active at low concentration.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Joelle DonadieuPhilippe DurandCatherine ProyBernard SpechtDominique ClesseEmilie Deschamps-OstanciauxMichel DiamentRaphael GrandinElisabeth PointalMarie-Pierre DoinChristophe LaurentErwan PathierFranck ThollardCécile LasserreLaëtitia Lemrabet
• Organismes : Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut des Sciences de la Terre Institut des Sciences de la Terre Institut des Sciences de la Terre Institut des Sciences de la Terre Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Gilles DromartJean-Pierre SucSperanta-Maria PopescuEmmanuel EgalJean-Loup RubinoPhilippe Sorrel
• Organismes : Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut des Sciences de la Terre de Paris Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Maxime GilletPierre-Alain AyralCorinne Le Gal La SallePatrick VerdouxMahmoud KhaskaPhilippe MartinJean-François Didon-LescotJean-Marc DomergueNadine GrardChristian Lopez
• Organismes : Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Mengjia WangWigneron J.-P.Rui SunSassan S SaatchiFrédéric FrappartShengli TaoLinna ChaiXiaojun LiXiangzhuo LiuHongliang MaChristophe MoisyPhilippe Ciais
• Organismes : Interactions Sol Plante Atmosphère State Key Laboratory of Remote Sensing Science [Beijing] Beijing Normal University Interactions Sol Plante Atmosphère State Key Laboratory of Remote Sensing Science [Beijing] Beijing Normal University Southwest University [Chongqing] Interactions Sol Plante Atmosphère Laboratoire d'études en Géophysique et océanographie spatiales Evolution et Diversité Biologique State Key Laboratory of Earth Surface Processes and Resource Ecology Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]
• Publié dans International Journal of Applied Earth Observation and Geoinformation le 27/10/2020

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Résumé : Vegetation optical depth (VOD) retrieved from microwave remote sensing techniques has been used as an important proxy for monitoring the vegetation dynamics at large scales. In a first study we developed a new X-VOD indice from inversion of the X-MEB model from the Microwave Scanning Radiometer 2 (AMSR2, 2012-present) observations. The Advanced Microwave Scanning Radiometer for EOS (AMSR-E, 2002–2011) and AMSR2 share many characteristics, such as local crossing time, incidence angle, frequency at X-band, etc, which makes it possible to produce a consistent long-term X-VOD product over a long period spanning from 2002 to present. The objective of this study was to merge the AMSR-E and AMSR2 observations in order, in a second step, to produce a consistent long-term X-VOD product spanning over the combined periods of AMSR-E and AMSR2.The main challenges in retrieving a consistent X-VOD data set from AMSR-E and AMSR2 are that (i) there is a bias between observations from the two sensors; and (ii) the lack of overlapping observations between the two sensors makes it impossible to achieve a direct inter-calibration. Here, to overcome this problem, we used AMSR-E slow rotation data (AMSR-E L1S), which has similar characteristics as AMSR-E and provided observations concurrently with AMSR2, as a bridge to calibrate the AMSR-E brightness temperature (TB) observations with AMSR2 TB.As our main objective in this TB calibration study was to produce a consistent long-term AMSR-E/AMSR2 X-VOD product, we evaluated the retrieved X-VOD product based on different inter-calibration, either global-based or pixel-based, methods. Both AMSR-E and AMSR2 X-VOD were evaluated against the Aboveground Biomass (AGB), Leaf Area Index (LAI) and the Normalized Difference Vegetation Index (NDVI). The results suggest that global-based inter-calibration methods using homogeneous and temporally stable land covers (Evergreen Broadleaf Forests and Snow and Ice) as reference calibration data sets provided the best results. For instance, the spatial relationships between X-VOD and AGB/LAI/NDVI are highly consistent over the AMSR-E and AMSR2 periods after the calibration work. This study laid a solid foundation for monitoring the dynamics of X-VOD, as a proxy of AGB, over the combined periods of AMSR-E and AMSR2 sensors (almost 20 years).

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Fichiers liés : 2021-Wang-IJAEOG.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2021
• Auteurs : Jonas VanardoisPierre TrapRoger FrançoiseFabrice BarouPierre LanariPhilippe GoncalvesDidier MarquerJean-Louis PaquetteKévin FrévilleFlorence CagnardBenjamin Le BayonJérémie Melleton
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249) Géosciences Montpellier Géosciences Montpellier Universität Bern = University of Bern = Université de Berne Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249) Laboratoire Magmas et Volcans Laboratoire Chrono-environnement (UMR 6249) Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières

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Résumé : The Aiguilles-Rouges Massif (ARM) basement is mostly composed of migmatitic gneisses and micaschists hosting metric boudins of retrograded eclogites and amphibolites. In the SW part of the massif, these high-grade rocks are overlaid by low-grade metamorphosed Carboniferous volcano-detritic sediments Three main deformations, named D1, D2 and D3, have been described in the Variscan basement of the ARM. When D1 relicts are preserved in low-D2 strain domains, they correspond to a flat-lying S1 foliation only preserved in the gneissic core. This D1 is associated with partial melting metamorphic event M1. D2 is characterized by three main orientations of planar fabrics, oriented toward N160, N0 and N20 directions and forming S2- C2-C2’ structures, respectively. They are related to a bulk non-coaxial anastomosed system developed under dextral transpression. D3 corresponds to a flat-lying cleavage associated to vertical shortening and folding of previous foliations. This deformation has only been observed in the upper structural levels of the gneissic basement and within the Visean sediments. Field observations and EBSD data on eclogitic boudins indicate that D1 deformation is posterior to the relictual high pressure paragenesis, while D2 is synchronous with the retrogression of the eclogites into amphibolites. U-Th-Pb LA-IC-PMS datings on Zircon, Monazite and Rutile indicate that high-pressure metamorphism is recorded at ca. 335-330 Ma in the eclogitic boudins, whereas the M2 peak of temperature in surrounding metapelites ranges between 325 and 315 Ma. The exhumation of the Variscan basement, related to D2 dextral shearing and D3 crustal thinning, occurred between 315 and 300 Ma. These new results indicate a Variscan geodynamic evolution from high pressure conditions to late exhumation ranging between ca. 335 and 300 Ma in the ARM.

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