Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 20/09/2021
• Auteurs : Jim ZoladekVincent LegrosPatricia JeanninMaxime ChazalNathalie PardigonPierre-Emmanuel CeccaldiAntoine GessainNolwenn JouvenetPhilippe V Afonso
• Organismes : Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Centre International de Recherche en Infectiologie Virus enveloppés, vecteurs et immunothérapie – Enveloped viruses, Vectors and Immuno-therapy [CIRI] Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Institut Pasteur [Paris] Signalisation antivirale - Virus sensing and signaling Institut Pasteur [Paris] Environnement et Risques infectieux - Environment and Infectious Risks Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Institut Pasteur [Paris] Signalisation antivirale - Virus sensing and signaling Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology UFR Sciences du Vivant [Sciences] - Université Paris Cité
• Publié dans Frontiers in Microbiology le 31/10/2020

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Résumé : Zika virus (ZIKV) infection has been associated with a series of neurological pathologies. In patients with ZIKV-induced neurological disorders, the virus is detectable in the central nervous system. Thus, ZIKV is capable of neuroinvasion, presumably through infection of the endothelial cells that constitute the blood-brain barrier (BBB). We demonstrate that susceptibility of BBB endothelial cells to ZIKV infection is modulated by the expression of tight-junction protein claudin-7 (CLDN7). Downregulation of CLDN7 reduced viral RNA yield, viral protein production, and release of infectious viral particles in several endothelial cell types, but not in epithelial cells, indicating that CLDN7 implication in viral infection is cell-type specific. The proviral activity of CLDN7 in endothelial cells is ZIKV-specific since related flaviviruses were not affected by CLDN7 downregulation. Together, our data suggest that CLDN7 facilitates ZIKV infection in endothelial cells at a post-internalization stage and prior to RNA production. Our work contributes to a better understanding of the mechanisms exploited by ZIKV to efficiently infect and replicate in endothelial cells and thus of its ability to cross the BBB.

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Fichiers liés : fmicb-12-746589.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/09/2021
• Auteurs : Pierre-Jean BouvetPhilippe ForjonelBeatrice TomasiYves AuffretYassine AmiratGilles FeldMaëlle DenielPauline Simon
• Organismes : Systèmes Embarqués, Acoustique et Télécommunications Systèmes Embarqués, Acoustique et Télécommunications Laboratoire ISEN Laboratoire ISEN Energie et Systèmes Electromécaniques Laboratoire ISEN Laboratoire ISEN Laboratoire ISEN

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Résumé : Due to the water's characteristics, especially salt water, electromagnetic fields are quickly dissipated and absorbed in underwater environment. Thus, to transfer data in this medium, acoustic signals are mostly used due to their capability to transmit data over a long range. However, at very short range, electromagnetic signals enable high rate wireless data transfer in the underwater medium. The objective of this paper is to investigate underwater contactless data transfer technologies between an Autonomous Underwater Vehicle (AUV) and its docking station. On one hand, we consider 5 GHz Wi-Fi based transmission prototype and provide experimental end-to-end data performance for several transmission range, rotation angles, non-perfect alignment and transmit power. On the other hand we investigate the achievable rate of an experimental Magnetic Induction (MI) prototype performing contactless power and data transfer.

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Fichiers liés : Full_paper_Oceans_21_Contactless_data_transfer_for_autonomous_underwater_vehicle_docking_station.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/09/2021
• Auteurs : Brendan Le PicaultCharles-Henri DavidPierre-Louis AlexandreCédric LenoblePhilippe BizouarnThierry LepoivreNicolas GroleauBertrand RozecHubert DesalJean-Christian RousselThomas Sénage
• Organismes : Service de Chirurgie Cardio-Thoracique [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de Chirurgie Cardio-Thoracique [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de neuroradiologie [Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de neuroradiologie [Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de neuroradiologie [Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de Chirurgie Cardio-Thoracique [CHU Nantes] methodS in Patients-centered outcomes and HEalth ResEarch Service de Chirurgie Cardio-Thoracique [CHU Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Bioengineering le 01/11/2020

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Résumé : Introduction: Circulatory assistance from a SynCardia Total Artificial Heart (SynCardia-TAH) is a reliable bridge-to-transplant solution for patients with end-stage biventricular heart failure. Ischemic strokes affect about 10% of patients with a SynCardia-TAH. We report for the first time in the literature two successful thrombectomies to treat the acute phase of ischemic stroke in two patients treated with a SynCardia-TAH in the bridge-to-transplant (BTT). Case report: We follow two patients with circulatory support from a SynCardia-TAH in the bridge-to-transplant for terminal biventricular cardiac failure with ischemic stroke during the support period. An early in-hospital diagnosis enables the completion of a mechanical thrombectomy within the first 6 h of the onset of symptoms. There was no intracranial hemorrhagic complication during or after the procedure and the patients fully recovered from neurological deficits, allowing a successful heart transplant. Conclusion: This case report describes the possibility of treating ischemic strokes under a SynCardia-TAH by mechanical thrombectomy following the same recommendations as for the general population with excellent results and without any hemorrhagic complication during or after the procedure.

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• Type de publi. : Article dans une revue
• Date de publi. : 18/09/2021
• Auteurs : Sifat SharminMathilde LefortJohanna Balslev AndersenEmmanuelle LerayDana HorakovaEva Kubala HavrdovaRaed AlroughaniGuillermo IzquierdoSerkan OzakbasFrancesco PattiMarco OnofrjAlessandra LugaresiMurat TerziPierre GrammondFrancois Grand’maisonBassem YamoutAlexandre PratMarc GirardPierre DuquetteCavit BozMaria TrojanoPamela MccombeMark SleeJeannette Lechner-ScottRecai TurkogluPatrizia SolaDiana FerraroFranco GranellaJulie Prévost-ZuddasDavide MaimoneOlga SkibinaKatherine BuzzardAnneke van Der WaltBart van WijmeerschTunde CsepanyDaniele SpitaleriSteve VucicRomain CaseyMarc DebouverieGilles EdanJonathan CironAurélie RuetJérôme de SèzeElisabeth MaillartHélène ZéphirPierre M LabaugeGilles DeferChristine Lebrun-FrénayThibault MoreauEric BergerPierre ClavelouJean PelletierBruno StankoffOlivier GoutEric ThouvenotOlivier HeinzlefAbullatif Al-KhedrBertrand BourreOlivier CasezPhilippe CabreAlexis MontcuquetAbir WahabJean-Philippe CamdessanchéAude MauroussetIvania PatryKarolina HankiewiczCorinne PottierNicolas MaubeugeCéline LabeyrieChantal NifleDavid-Axel LaplaudNiels Koch-HenriksenFinn Thorup SellebjergPer Soelberg SoerensenClaudia Christina PflegerPeter Vestergaard RasmussenMichael Broksgaard JensenJette Lautrup FrederiksenStephan BramowHenrik Kahr MathiesenKaren Ingrid SchreiberMelinda MagyariSandra VukusicHelmut ButzkuevenTomas Kalincik
• Organismes : University of Melbourne Recherche en Pharmaco-épidémiologie et Recours aux Soins Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique University of Copenhagen = Københavns Universitet École des Hautes Études en Santé Publique Recherche en Pharmaco-épidémiologie et Recours aux Soins Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Département Méthodes quantitatives en santé publique Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] Amiri hospital Hospital Virgen Macarena Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] Università degli studi di Catania = University of Catania G.F. Ingrassia Hospital Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara] Alma Mater Studiorum Università di Bologna = University of Bologna Institute of Neurological Science of Bologna Ondokuz Mayis University American University of Beirut Faculty of Medicine and Medical Center Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Karadeniz Technical University Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro The University of Queensland Royal Brisbane and Women's Hospital [Herston, Queensland, Australia] Flinders University [Adelaide, Australia] University of Newcastle [Callaghan, Australia] Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena Università degli studi di Parma = University of Parma Azienda Ospedaliero-Universitaria di Parma = Maggiore Hospital in Parma Monash University [Melbourne] The Alfred Hospital The Alfred Hospital Monash University [Melbourne] The Alfred Hospital Monash University [Melbourne] Hasselt University University of Debrecen San Giuseppe Moscati Hospital [Avellino, Italie] Westmead Hospital [Sydney] Université Claude Bernard Lyon 1 Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Adaptation, mesure et évaluation en santé. Approches interdisciplinaires Service de neurologie [CHRU Nancy] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Toulouse Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale CIC Bordeaux CIC Strasbourg CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [Montpellier] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Pasteur [Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) CHU Clermont-Ferrand Neuro-Dol Hôpital de la Timone [CHU - APHM] Institut du Cerveau = Paris Brain Institute Fondation Ophtalmologique Adolphe de Rothschild [Paris] Institut de Génomique Fonctionnelle CHI Poissy-Saint-Germain Service de neurologie [Amiens] Service de neurologie [Rouen] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Service de Neurologie [CHU Limoges] CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Sud Francilien Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier René Dubos [Pontoise] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier de Versailles André Mignot Centre d’Investigation Clinique de Nantes Centre de Recherche en Transplantation et Immunologie Aarhus University Hospital University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet Aalborg University Aarhus University Hospital University Hospital of Northern Sealand Rigshospitalet [Copenhagen, Denmark] University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Monash University [Melbourne] The Royal Melbourne Hospital
• Publié dans CNS Drugs le 30/10/2020

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Résumé : Introduction: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined.Objective: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest.Methods: Patients with RRMS who were given natalizumab or fingolimod were identified in a merged cohort from three international registries. Efficacy outcomes were compared across subgroups based on patients' sex, age, disease duration, Expanded Disability Status Scale (EDSS) score, and disease and magnetic resonance imaging (MRI) activity 12 months prior to treatment initiation. Study endpoints were number of relapses (analyzed with weighted negative binomial generalized linear model) and 6-month confirmed disability worsening and improvement events (weighted Cox proportional hazards model), recorded during study therapy. Each patient was weighted using inverse probability of treatment weighting based on propensity score.Results: A total of 5148 patients (natalizumab 1989; fingolimod 3159) were included, with a mean ± standard deviation age at baseline of 38 ± 10 years, and the majority (72%) were women. The median on-treatment follow-up was 25 (quartiles 15-41) months. Natalizumab was associated with fewer relapses than fingolimod (incidence rate ratio [IRR]; 95% confidence interval [CI]) in women (0.76; 0.65-0.88); in those aged ≤ 38 years (0.64; 0.54-0.76); in those with disease duration ≤ 7 years (0.63; 0.53-0.76); in those with EDSS score < 4 (0.75; 0.64-0.88), < 6 (0.80; 0.70-0.91), and ≥ 6 (0.52; 0.31-0.86); and in patients with pre-baseline relapses (0.74; 0.64-0.86). A higher probability of confirmed disability improvement on natalizumab versus fingolimod (hazard ratio [HR]; 95% CI) was observed among women (1.36; 1.10-1.66); those aged > 38 years (1.34; 1.04-1.73); those with disease duration > 7 years (1.33; 1.01-1.74); those with EDSS score < 6 (1.21; 1.01-1.46) and ≥ 6 (1.93; 1.11-3.34); and patients with no new MRI lesion (1.73; 1.19-2.51).Conclusions: Overall, in women, younger patients, those with shorter disease durations, and patients with pre-treatment relapses, natalizumab was associated with a lower frequency of multiple sclerosis relapses than fingolimod. It was also associated with an increased chance of recovery from disability among most patients, particularly women and those with no recent MRI activity.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2021
• Auteurs : Alpha Kabinet KeitaFara R. KoundounoMartin FayeAriane DüxJulia HinzmannHaby DialloAhidjo AyoubaFrédéric Le MarcisBarré SoropoguiKékoura IfonoMoussa M. DiagneMamadou S. SowJoseph A. BoreSebastien Calvignac-SpencerNicole VidalJacob CamaraMamadou B. KeitaAnnick ReneveyAmadou DialloAbdoul K. SoumahSaa L. MillimonoAlmudena Mari-SaezMamadou DiopAhmadou DoréFodé Y. SoumahKaka KouroumaNathalie J. VielleCheikh LoucoubarIbrahima CamaraKarifa KouroumaGiuditta AnnibaldisAssaïtou BahAnke ThielebeinMeike PahlmannSteven T. PullanMiles W. CarrollJoshua QuickPierre FormentyAnais LegandKarla PietroMichael R. WileyNoël TordoChristophe PeyrefitteJohn T. MccroneAndrew RambautYoussouf SidibéMamadou D. BarryMadeleine KouroumaCé D. SaouromouMamadou CondéMoussa BaldéMoriba PovoguiSakoba KeitaMandiou DiakiteMamadou S. BahAmadou SidibeDembo DiakiteFodé B. SakoFodé A. TraoreGeorges A. Ki-ZerboPhilippe LemeyStephan GüntherLiana E. KafetzopoulouAmadou A. SallEric DelaporteSophie DuraffourOusmane FayeFabian H. LeendertzMartine PeetersAbdoulaye ToureN'. Faly Magassouba
• Organismes : Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Université Gamal Abdel Nasser de Conakry Laboratoire des Fièvres Hémorragiques en Guinée Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] Institut Pasteur de Dakar Robert Koch Institute [Berlin] Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] German Center for Infection Research - Partner Site Hamburg-Lübeck-Borstel-Riems Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Triangle : action, discours, pensée politique et économique Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] Laboratoire des Fièvres Hémorragiques en Guinée Laboratoire des Fièvres Hémorragiques en Guinée Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] Institut Pasteur de Dakar Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] Hôpital National Donka Laboratoire des Fièvres Hémorragiques en Guinée The Wellcome Trust Centre for Human Genetics [Oxford] Epidemiology of Highly Pathogenic Microorganisms Robert Koch Institute [Berlin] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Laboratoire des Fièvres Hémorragiques en Guinée Vecteurs - Infections tropicales et méditerranéennes Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] German Center for Infection Research - Partner Site Hamburg-Lübeck-Borstel-Riems Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] Laboratoire des Fièvres Hémorragiques en Guinée Robert Koch Institute [Berlin] Robert Koch Institute [Berlin] CEA Tech Grand-Est Laboratoire des Fièvres Hémorragiques en Guinée Hôpital National Donka Institut National de Santé Publique [Conakry, Guinée] Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] Institut Pasteur de Dakar Laboratoire de Physique de l'Atmosphère et de l'Océan Siméon Fongang Laboratoire des Fièvres Hémorragiques en Guinée Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] Laboratoire des Fièvres Hémorragiques en Guinée Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] German Center for Infection Research - Partner Site Hamburg-Lübeck-Borstel-Riems Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] University of Oxford Public Health England Public Health England University of Oxford University of Birmingham [Birmingham] Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] The University of Texas Medical Branch University of Nebraska Medical Center Institut Pasteur de Guinée Unité des Virus Emergents Institut de Recherche Biomédicale des Armées [Antenne Marseille] The University of Edinburgh The University of Edinburgh Hôpital National Donka Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] Division Prévention et Lutte contre la Maladie Ministère de la Santé [Conakry, Guinea] Université Gamal Abdel Nasser de Conakry Ministère de la Santé [Conakry, Guinea] École normale supérieure de Lyon Hôpital National Donka Hôpital National Donka Hôpital National Donka Catholic University of Leuven = Katholieke Universiteit Leuven Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] German Center for Infection Research - Partner Site Hamburg-Lübeck-Borstel-Riems Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] German Center for Infection Research - Partner Site Hamburg-Lübeck-Borstel-Riems Catholic University of Leuven = Katholieke Universiteit Leuven Institut Pasteur de Dakar Infectious and Tropical Diseases Department [Montpellier] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes German Center for Infection Research - Partner Site Hamburg-Lübeck-Borstel-Riems Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] Université Cheikh Anta Diop de Dakar [Sénégal] Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Robert Koch Institute [Berlin] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] Institut National de Santé Publique [Conakry, Guinée] Laboratoire des Fièvres Hémorragiques en Guinée
• Publié dans Nature le 29/10/2020

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Fichiers liés : 398730Rambaut.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2021
• Auteurs : J. Russell HuieStefania MondelloChristopher LindsellLuca AntigaEsther YuhElisa ZanierSerge MassonBedda RosarioAdam FergusonOpeolu AdeoyeNeeraj BadjatiaKim BoaseYelena BodienM. Ross BullockRandall ChesnutJohn CorriganKaren CrawfordRamon Diaz-ArrastiaSureyya DikmenAnn-Christine DuhaimeRichard EllenbogenV. Ramana FeeserBrandon ForemanRaquel GardnerEtienne GaudetteJoseph GiacinoDana GoldmanLuis GonzalezShankar GopinathRao GullapalliJ. Claude HemphillGillian HotzSonia JainFrederick KorleyJoel KramerNatalie KreitzerHarvey LevinJoan MachamerChristopher MaddenGeoffrey ManleyAlastair MartinThomas McallisterMichael MccreaRandall MerchantPratik MukherjeeLindsay NelsonLaura NgwenyaFlorence NoelDavid OkonkwoDaniel PerlAva PuccioMiri RabinowitzClaudia RobertsonJonathan RosandAngelle SanderDavid SchnyerSeth SeaburyMurray SteinSabrina TaylorNancy TemkinArthur TogaAlex ValadkaMary VassarPaul VespaKevin WangJohn YueRoss ZafonteCecilia AckerlundHadie AdamsVanni AgnolettiJudith AllansonKrisztina AmreinNorberto AndaluzNada AndelicLasse AndreassenAudny AnkeAzasevac AntunAnna AntoniHilko ArdonKaspars AuslandsPhilippe AzouviMaria Luisa AzzoliniCamelia BaciuRafael BadenesRonald BartelsPál BarzóUrsula BauerfeindRomuald BeauvaisRonny BeerFrancisco Javier BeldaBo Michael BellanderAntonio BelliRémy BellierHabib BenaliThierry BenardMaurizio BerardinoLuigi BerettaChristopher BeynonFederico BilottaHarald BinderErta BiqiriMorten BlaabjergHugo Den BoogertPeter BraggeAlexandra BrazinovaVibeke BrinckJoanne BrookerCamilla BrorssonAndras BukiMonika BullingerManuel CabeleiraEmiliana CalappiMaria Rosa CalviPeter CameronLozano Guillermo CarbayoMarco CarbonaraElsa CariseK. CarpenterAna Castaño LeónFrancesco CausinGiorgio ChevallardArturo ChieregatoGiuseppe CiterioMaryse CnossenMark CoburnJonathan ColesLizzie Coles-KempJohnny CollettJamie CooperMarta CorreiaAmra CovicNicola CurryEndre CzeiterMarek CzosnykaClaire Dahyot FizelierFrançois DamasPierre DamasHelen DawesVéronique de KeyserFrancesco Della CorteBart DepreitereGodard C.W. de RuiterDula DilvesiShenghao DingDiederik DippelAbhishek DixitEmma DonoghueJens DreierGuy Loup DulièreHeiko EngemannAri ErcolePatrick EsserErzsébet EzerMartin FabriciusValery FeiginJunfeng FengKelly FoksFrancesca FossiGilles FranconyUlderico FreoShirin FrisvoldAlex FurmanovPablo GagliardoDamien GalanaudDashiell GantnerGuoyi GaoKarin GeleijnsPradeep GeorgeAlexandre GhuysenLelde GigaBenoit GiraudBen GlockerJagos GolubovicPedro GomezBenjamin GravesteijnFrancesca GrossiRussell GruenDeepak GuptaJuanita HaagsmaAsta Kristine HåbergBram JacobsIain HaitsmaJed HartingsRaimund HelbokEirik HelsethDaniel HertleAstrid HoedemaekersStefan HoeferLindsay HortonJilske HuijbenPeter HutchinsonStefan JankowskiMike JarrettBojan JelacaJi Yao JiangKelly JonesKonstantinos KamnitsasMladen KaranAri KatilaMaija KaukonenThomas KerforneRiku KivisaariAngelos KoliasBálint KolumbánErwin KompanjeKsenija KolundzijaDaniel KondziellaLars Owe KoskinenNoémi KovácsAlfonso LagaresLinda LanyonSteven LaureysFiona LeckyChristian LedigRolf LeferingValerie LegrandJin LeiLeon LeviRoger LightfootHester LingsmaDirk LoeckxAngels LozanoAndrew I.R. MaasStephen MacdonaldMarc MaegeleMajdan MarekSebastian MajorAlex ManaraGeoffrey ManleyDidier MartinLeon Francisco MartinCostanza MartinoHugues MaréchalArmando MaruendaAlessandro MasalaJulia MatternCharles McfadyenCatherine McmahonBéla MeleghDavid MenonTomas MenovskyCristina Morganti KossmannDavide MulazziHolger MühlanVisakh MuraleedharanLynnette MurrayNandesh NairAncuta NegruDavid NelsonVirginia NewcombeDaan NieboerQuentin NoirhommeJózsef NyirádiMauro OddoAnnemarie OldenbeuvingMatej OresicFabrizio OrtolanoAarno PalotiePaul ParizelAdriana PatrunoJean François PayenNatascha PereraVincent PerlbargPaolo PersonaWilco PeulAnna Piippo-KarjalainenFloury Sébastien PiliMatti PirinenHoria PlesMaria Antonia PocaSuzanne PolinderInigo PomposoJussi PostiLouis PuybassetAndreea RadoiArminas RagauskasRahul RajMalinka RambadagallaRuben RealVeronika RehorčíkováJonathan RhodesSamuli RipattiSaulius RockaCecilie RoeOlav RoiseGerwin RoksJonathan RosandJeffrey RosenfeldChristina RosenlundGuy RosenthalRolf RossaintSandra RossiDaniel RueckertMartin RusnákMarco SacchiBarbara SahakianJuan SahuquilloOliver SakowitzFrancesca SalaRenan Sanchez PorrasJanos SandorEdgar SantosLuminita SasuDavide SavoNadine SchäfferInger SchipperBarbara SchlößerSilke SchmidtHerbert SchoechlGuus SchoonmanRico Frederik SchouElisabeth SchwendenweinMichael SchöllCharlie SewaltÖzcan SirToril SkandsenLidwien SmakmanDirk SmeetsPeter SmielewskiAbayomi SorinolaEmmanuel StamatakisSimon StanworthNicole SteinbüchelAna StevanovicRobert StevensWilliam StewartEwout SteyerbergNino StocchettiNina SundströmAnneliese SynnotFabio Silvio TacconeRiikka TakalaViktória TamásPäivi TanskanenMark Steven TaylorBraden Te AoOlli TenovuoRalph TelgmannGuido TeodoraniAlice TheadomMatt ThomasDick TibboelChristos ToliasJean Flory Luaba TshibandaTony TrapaniCristina Maria TudoraPeter VajkoczyShirley VallanceEgils ValeinisGregory Van Der SteenMathieu Van Der JagtJv de NaaltJeroen T.J.M. van DijckThomas van EssenWim Van HeckeCaroline Van HeugtenDominique Van PraagThijs Vande VyvereJulia Van WaesbergheAudrey VanhaudenhuyseAlessia VargioluEmmanuel VegaKimberley VeltJan VerheydenPaul VespaAnne VikRimantas VilcinisGiacinta VizzinoCarmen Vleggeert LankampVictor VoloviciDaphne VoormolenPeter VulekovicZoltán VámosDerick WadeKevin K.W. WangLei WangLars WesselsEveline WiegersEno WildschutGuy WilliamsLindsay WilsonMaren K.L. WinklerStefan WolfPeter YlénAlexander YounsiMenashe ZaaroorFrederik ZeilerYang ZhihuiAgate ZiverteFabrizio Zumbo
• Organismes : Università degli Studi di Messina = University of Messina orobix Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research Department of Neurosurgery University of Pennsylvania [Philadelphia] Massachusetts General Hospital [Boston]
• Publié dans Journal of Neurotrauma le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 14/09/2021
• Auteurs : Elsa TavernierFrancois BarbierFerhat MezianiJean-Pierre QuenotJean-Etienne HerbrechtMickael LandaisDamien RouxPhilippe SeguinDavid SchnellAnne VeinsteinBenoît VeberSigismond LasockiQin LuGaetan BeduneauMartine FerrandiereClaire Dahyot-FizelierGaetan PlantefeveMai-Anh NayHamid MerdjiPascal AndreuLaurent VecellioGrégoire MullerMaria CabreraDeborah Le PennecPhilippe LanotteRenaud RespaudNicolas GrégoireMarie LeclercJulie HelmsThierry BoulainJean-Claude LacheradeStephan Ehrmann
• Organismes : Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Regional d'Orléans Hôpitaux Universitaires de Strasbourg Lipides - Nutrition - Cancer [Dijon - U1231] Hôpitaux Universitaires de Strasbourg Centre Hospitalier Le Mans (CH Le Mans) Hôpital Louis Mourier - AP-HP [Colombes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier d'Angoulême Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU Rouen Centre Hospitalier Universitaire d'Angers CHU Pitié-Salpêtrière [AP-HP] CHU Rouen Centre Hospitalier Régional Universitaire de Tours Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Pharmacologie des anti-infectieux [U 1070] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre Hospitalier Regional d'Orléans Hôpitaux Universitaires de Strasbourg Lipides - Nutrition - Cancer [Dijon - U1231] Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Regional d'Orléans Centre d’Etude des Pathologies Respiratoires [Tours] Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Régional Universitaire de Tours Infectiologie et Santé Publique Centre d’Etude des Pathologies Respiratoires [Tours] Pharmacologie des anti-infectieux [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Régional Universitaire de Tours Hôpitaux Universitaires de Strasbourg Centre Hospitalier Regional d'Orléans Centre Hospitalier Départemental Vendée Centre Hospitalier Régional Universitaire de Tours
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction: Pre-emptive inhaled antibiotics may be effective to reduce the occurrence of ventilator-associated pneumonia among critically ill patients. Meta-analysis of small sample size trials showed a favourable signal. Inhaled antibiotics are associated with a reduced emergence of antibiotic resistant bacteria. The aim of this trial is to evaluate the benefit of a 3-day course of inhaled antibiotics among patients undergoing invasive mechanical ventilation for more than 3 days on the occurrence of ventilator-associated pneumonia. Methods and analysis: Academic, investigator-initiated, parallel two group arms, double-blind, multicentre superiority randomised controlled trial. Patients invasively ventilated more than 3 days will be randomised to receive 20 mg/kg inhaled amikacin daily for 3 days or inhaled placebo (0.9% Sodium Chloride). Occurrence of ventilator-associated pneumonia will be recorded based on a standardised diagnostic framework from randomisation to day 28 and adjudicated by a centralised blinded committee. Ethics and dissemination: The protocol and amendments have been approved by the regional ethics review board and French competent authorities (Comité de protection des personnes Ouest I, No.2016-R29). All patients will be included after informed consent according to French law. Results will be disseminated in international scientific journals. Trial registration numbers: EudraCT 2016-001054-17 and NCT03149640.

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Fichiers liés : e048591.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/09/2021
• Auteurs : A.-Ran LyoJongsoo KimSarah SadavoyDoug JohnstoneDavid BerryKate PattleWoojin KwonPierre BastienTakashi OnakaJames Di FrancescoJi-Hyun KangRay FuruyaCharles L H HullMotohide TamuraPatrick M KochDaniel R. van RossumTetsuo HasegawaThiem HoangDoris ArzoumanianChang Won LeeChin-Fei LeeDo-Young ByunFlorian KirchschlagerYasuo DoiKee-Tae KimJihye HwangPham Ngoc DiepLapo FanciulloSang-Sung LeeGeumsook ParkHyunju YooEun Jung ChungAnthony WhitworthSteve MairsArchana SoamTie 铁 Liu 刘Xindi TangSimon CoudéPh. AndréTyler BourkeHuei-Ru Vivien ChenZhiwei ChenWen Ping ChenMike ChenTao-Chung ChingJungyeon ChoMinho ChoiYunhee ChoiA. ChrysostomouSophia DaiC. Darren DowellHao-Yuan DuanYan DuanD. EdenChakali EswaraiahStewart EyresJason FiegeLaura FisselErica FranzmannPer FribergRachel FriesenGary FullerTim GledhillSarah GravesJane GreavesMatt GriffinQi-Lao 琦烙 Gu 顾Ilseung HanJennifer HatchellSaeko HayashiMartin HoudeTsuyoshi InoueShu-Ichiro InutsukaKazunari IwasakiIl-Gyo JeongMiju KangAkimasa KataokaKoji S KawabataFrancisca KemperGwanjeong KimMi-Ryang KimShinyoung KimKyoung Hee KimJason KirkMasato KobayashiVera KönyvesTakayoshi KusuneJungmi KwonKevin LacailleShih-Ping LaiChi-Yan LawJeong-Eun LeeYong-Hee LeeHyeseung LeeDalei LiDi LiHua-Bai LiHong-Li LiuJunhao LiuSheng-Yuan LiuXing LuMasafumi 雅文 Matsumura 松村Brenda MatthewsGerald Moriarty-SchievenTetsuya NagataSandhyarani PanigrahyHiroyuki NakanishiNguyen Bich NgocNagayoshi OhashiHarriet ParsonsNicolas PerettoFelix PriestleyTae-Soo PyoLei QianKeping QiuRamprasad RaoJonathan RawlingsMark RawlingsBrendan RetterJohn RicherAndrew RigbyHiro SaitoGiorgio SaviniAnna ScaifeMasumichi SetaYoshito ShimajiriHiroko ShinnagaMehrnoosh TahaniYa-Wen TangKohji TomisakaLe Ngoc TramYusuke TsukamotoSerena VitiJia-Wei WangHongchi WangJinjin XieHsi-Wei YenJinghua YuanHyeong-Sik YunTetsuya ZenkoGuoyin ZhangChuan-Peng ZhangYapeng ZhangJianjun ZhouLei ZhuIlse de LoozeC. Darren DowellSam FalleJean-François RobitailleSven van Loo
• Organismes : Korea Astronomy and Space Science Institute Max Planck Institute for Radio Astronomy
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : Abstract We present the results of simultaneous 450 μ m and 850 μ m polarization observations toward the massive star-forming region NGC 2071IR, a target of the BISTRO ( B -fields in STar-forming Region Observations) Survey, using the POL-2 polarimeter and SCUBA-2 camera mounted on the James Clerk Maxwell Telescope. We find a pinched magnetic field morphology in the central dense core region, which could be due to a rotating toroidal disklike structure and a bipolar outflow originating from the central young stellar object IRS 3. Using the modified Davis–Chandrasekhar–Fermi method, we obtain a plane-of-sky magnetic field strength of 563 ± 421 μ G in the central ∼0.12 pc region from 850 μ m polarization data. The corresponding magnetic energy density of 2.04 × 10 −8 erg cm −3 is comparable to the turbulent and gravitational energy densities in the region. We find that the magnetic field direction is very well aligned with the whole of the IRS 3 bipolar outflow structure. We find that the median value of polarization fractions is 3.0% at 450 μ m in the central 3′ region, which is larger than the median value of 1.2% at 850 μ m. The trend could be due to the better alignment of warmer dust in the strong radiation environment. We also find that polarization fractions decrease with intensity at both wavelengths, with slopes, determined by fitting a Rician noise model of 0.59 ± 0.03 at 450 μ m and 0.36 ± 0.04 at 850 μ m, respectively. We think that the shallow slope at 850 μ m is due to grain alignment at the center being assisted by strong radiation from the central young stellar objects.

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• Type de publi. :
• Date de publi. : 13/09/2021
• Auteurs : Qingfeng ShaoCunding HeJean-Jacques BahainAnne PhilippePierre VoinchetMin LinMengjie HuangMangu Jin
• Organismes : Key Laboratory of Virtual Geographic Environment (Nanjing Normal University), Ministry of Education, Nanjing 210023, China School of Cultural Heritage, Northwest University, Xi'an Histoire naturelle de l'Homme préhistorique Laboratoire de Mathématiques Jean Leray Histoire naturelle de l'Homme préhistorique China Institute of Atomic Energy Key Laboratory of Virtual Geographic Environment (Nanjing Normal University), Ministry of Education, Nanjing 210023, China Key Laboratory of Virtual Geographic Environment (Nanjing Normal University), Ministry of Education, Nanjing 210023, China

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• Type de publi. : Article dans une revue
• Date de publi. : 13/09/2021
• Auteurs : Frédéric GazeauCéline RidameFrance van WambekeSamir AlliouaneChristian StolpeJean-Olivier IrissonSophie MarroJean-Michel GrisoniGuillaume de LiègeSandra Helias NunigeKahina DjaoudiElvira Pulido-VillenaJulie DinasquetIngrid ObernostererPhilippe CatalaCécile Guieu
• Organismes : Laboratoire d'océanographie de Villefranche Cycles biogéochimiques marins : processus et perturbations Institut méditerranéen d'océanologie Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Institut de la Mer de Villefranche Institut de la Mer de Villefranche Institut méditerranéen d'océanologie Institut méditerranéen d'océanologie Institut méditerranéen d'océanologie Scripps Institution of Oceanography Laboratoire d'Océanographie Microbienne Laboratoire d'Océanographie Microbienne Laboratoire d'Océanographie Microbienne Laboratoire d'océanographie de Villefranche
• Publié dans Biogeosciences le 01/11/2020

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Résumé : In low-nutrient low-chlorophyll areas, such as the Mediterranean Sea, atmospheric fluxes represent a considerable external source of nutrients likely supporting primary production, especially during periods of stratification. These areas are expected to expand in the future due to lower nutrient supply from sub-surface waters caused by climate-driven enhanced stratification, likely further increasing the role of atmospheric deposition as a source of new nutrients to surface waters. Whether plankton communities will react differently to dust deposition in a warmer and acidified environment remains; however, an open question. The potential impact of dust deposition both in present and future climate conditions was investigated in three perturbation experiments in the open Mediterranean Sea. Climate reactors (300 L) were filled with surface water collected in the Tyrrhenian Sea, Ionian Sea and in the Algerian basin during a cruise conducted in the frame of the PEACETIME project in May–June 2017. The experiments comprised two unmodified control tanks, two tanks enriched with a Saharan dust analogue and two tanks enriched with the dust analogue and maintained under warmer (+3 ∘C) and acidified (−0.3 pH unit) conditions. Samples for the analysis of an extensive number of biogeochemical parameters and processes were taken over the duration (3–4 d) of the experiments. Dust addition led to a rapid release of nitrate and phosphate, however, nitrate inputs were much higher than phosphate. Our results showed that the impacts of Saharan dust deposition in three different basins of the open northwestern Mediterranean Sea are at least as strong as those observed previously, all performed in coastal waters. The effects of dust deposition on biological stocks were different for the three investigated stations and could not be attributed to differences in their degree of oligotrophy but rather to the initial metabolic state of the community. Ocean acidification and warming did not drastically modify the composition of the autotrophic assemblage, with all groups positively impacted by warming and acidification. Although autotrophic biomass was more positively impacted than heterotrophic biomass under future environmental conditions, a stronger impact of warming and acidification on mineralization processes suggests a decreased capacity of Mediterranean surface plankton communities to sequester atmospheric CO2 following the deposition of atmospheric particles.

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Fichiers liés : bg-18-5011-2021.pdf

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