Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/09/2021
• Auteurs : Jean-Philippe SarretteValentin FerrerAndré RicardJ P GardouF. Marchal
• Organismes : Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre

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Résumé : Reduced pressure (2-20 Torr) flowing afterglows initiated in N2 and in mixtures of N2 with rare (Ar,He) or molecular (H2) gases generate and transport high concentrations of active species (atoms, metastable states, …) that can be used in many applications including surface sterilization or surface treatments. In the present paper, N2, Ar/N2, He/N2 and H2/N2 microwave flowing afterglows were characterized by Optical Emission Spectroscopy (OES). The discharge was generated by a surfatron cavity (2.45 GHz) in a 5 mm i.d. quartz tube enlarging to a 50 cm in length and 18 mm i.d. tube.N2 1+ (11-7), N2+ 1- (0-0), N2 2+ (1-0), NO β (0-8) and NH A-X (0-0) band intensity ratios were used to obtain absolute concentrations of N, O (oxygen been present as gas impurity) and H atoms, of N2(A) and N2(X,<13) metastable states and of N2+ ions and NH molecules, assuming a simplified set of chemical reactions in the afterglow [1]. Active species densities measured up to 50 cm from the surfatron gap in a N2 (0.5 slpm, 4 Torr) afterglow are shown Fig.1.In parallel with OES, absolute atomic densities of N and H atoms were also measured using a two-photon laser induced fluorescence technique (TALIF). In this experiment, a tunable dye laser pumped by a the second harmonic of a Nd:YAG laser was operated in the red spectral range, from 591 to 636 nm. The output beam was frequency doubled by a BBO crystal and the resulting UV beam was frequency mixed with the residual dye laser beam in a second BBO crystal. The UV laser radiations are located in the UV-C wavelength range, from 202 to 212 nm. The laser beam was focused at a constant position on the axis of the 18 mm afterglow tube while the surfatron was moved on the 5 mm tube to vary the distance between the discharge and the measuring point. Calibration of TALIF signals was performed in situ but without afterglow, using the same gas mixture containing krypton.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/09/2021
• Auteurs : S. Al SaatiNoé ClémentMichel BlancYuxian WangNicolas AndréCorentin LouisLaurent LamyPierre‐louis BlellyP. LouarnAurélie MarchaudonJean‐claude GérardBertrand BonfondDenis GrodentBianca Maria DinelliAlberto AdrianiA. MuraBarry MaukGeorges ClarkFrederick AllegriniS. Bolton
• Organismes : Institut de recherche en astrophysique et planétologie Centre de Physique Théorique Institut de recherche en astrophysique et planétologie Laboratoire d'Astrophysique de Bordeaux [Pessac] Institut de recherche en astrophysique et planétologie National Space Science Center [Beijing] Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie School of Cosmic Physics [Dublin] Laboratoire d'Astrophysique de Marseille Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire de Physique Atmosphérique et Planétaire Istituto di Scienze dell'Atmosfera e del Clima [Bologna] Istituto Nazionale di Astrofisica [Rome] Istituto Nazionale di Astrofisica [Rome] Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Southwest Research Institute [San Antonio] Southwest Research Institute [San Antonio]

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Résumé : The dynamics of the Jovian magnetosphere is controlled by the complex interplay of the planet's fast rotation, its solar-wind interaction and its main plasma source at the Io torus. At the ionospheric level, these MIT coupling processes can be characterized by a set of key parameters which include ionospheric conductances, currents and electric fields, exchanges of particles along field lines and auroral emissions. Knowledge of these key parameters in turn makes it possible to estimate the net deposition/extraction of momentum and energy into/out of the Jovian upper atmosphere. In this talk we will extend to the first thirty Juno science orbits the method described in Wang et al. (JGR 2021, under review) which combines Juno multi-instrument data (MAG, JADE, JEDI, UVS, JIRAM and WAVES), adequate modelling tools and data bases to retrieve these key parameters along the Juno magnetic footprint and across the north and south auroral ovals. We will present preliminary distributions of conductances, electric currents and electric fields obtained from these orbits and will compare them with model predictions.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/09/2021
• Auteurs : Delphine MasséNathalie CassamEmmanuel FernandezDenis FillouxBruno HostachyEric VerdinSébastien MassartArmelle MaraisThierry CandressePhilippe RoumagnacPierre LefeuvreJean-Michel Lett
• Organismes : Unité Ravageurs et agents pathogènes tropicaux Unité Ravageurs et agents pathogènes tropicaux Plant Health Institute of Montpellier Département Systèmes Biologiques Plant Health Institute of Montpellier Département Systèmes Biologiques Unité Ravageurs et agents pathogènes tropicaux Unité de Pathologie Végétale Gembloux Agro-Bio Tech [Faculté universitaire des sciences agronomiques de Gembloux] Biologie du fruit et pathologie Biologie du fruit et pathologie Plant Health Institute of Montpellier Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques

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Résumé : HTS technology are now routinely used for virus discovery, but have yet to replace more conventional approaches for virus detection. Here, we compared five different HTS methods for virus detection: 1) ribo-depleted total RNA, 2) Double-stranded RNA (dsRNA), 3) Virus-derived small interfering RNAs (siRNA), 4) Virion-associated nucleic acids (VANA), and 5) total RNA with Oxford Nanopore Technologies (ONT) and MinION plateform. Pineapples from Reunion Island, displaying wilt symptoms, were tested in order to properly assess the performance and application range of each method.From the combination of all generated sequences, we were able to assemble nearly full genomes of viruses known to be associated with the Mealybug wilt disease of pineapple: Four distinct Pineapple mealybug wilt-associated virus species (PMWaV1, -2, -3 and -5) and the Pineapple bacilliform comosus virus (PBCoV) were characterized. Moreover, the genomes of a Sadwavirus and three new viruses belonging to the Ampelovirus (n=2) and Vitivirus (n=1) genera were also fully assembled.The comparison of the detection of each virus, using each tested method proves that all were suitable for the detection of all viruses, providing a sufficient coverage depth. The results showed that the ribo-depleted total RNA appears to be the best strategy to obtain nearly complete genomes, whether for RNA or DNA viruses, with or without poly-A tail. Conversely, total RNA with ONT failed for the complete reconstruction of most viral genomes.Globally, the discovery of new viruses proves the importance of diagnostic HTS tests and their inclusivity in understanding disease etiology and further highlight the diversity of viruses associated with pineapple

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Fichiers liés : Abstract_Aussois_sept2021_Masse_Delphine_Oral.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/09/2021
• Auteurs : Bin ZhouRodrigo Carrillo-LarcoGoodarz DanaeiLeanne RileyChristopher PaciorekGretchen StevensEdward GreggJames BennettBethlehem SolomonRosie SingletonMarisa SophieaMaria Lc IurilliVictor Pf LhosteMelanie CowanStefan SavinMark WoodwardYulia BalanovaRenata CifkovaAlbertino DamascenoPaul I P ElliottFarshad FarzadfarJiang HeNayu IkedaAndre KengneYoung-Ho KhangHyeon Chang KimAvula LaxmaiahHsien-Ho LinPaula Margozzini MairaJ Jaime MirandaHannelore NeuhauserJohan SundströmCherian VargheseIndah WidyaheningTomasz ZdrojewskiLeandra Abarca-GómezZiad AbdeenHanan Abdul RahimNiveen Abu-RmeilehBenjamin Acosta-CazaresRobert AdamsWichai AekplakornKaosar AfsanaShoaib AfzalImelda AgdeppaJavad Aghazadeh-AttariCarlos Aguilar-SalinasCharles AgyemangNoor Ani AhmadAli AhmadiNaser AhmadiNastaran AhmadiFariba AhmadizarSoheir AhmedWolfgang AhrensKamel AjlouniRajaa Al-RaddadiMonira AlaroujFadia AlbuhairanShahla AldhukairMohamed AliAbdullah AlkandariAla'A AlkerwiKristine AllinEman AlyDeepak AmarapurkarNorbert AmougouPhillippe AmouyelLars Bo AndersenSigmund AnderssenRanjit Mohan AnjanaAlireza Ansari-MoghaddamDaniel AnsongHajer Aounallah-SkhiriJoana AraújoInger AriansenTahir ArisRaphael ArkuNimmathota ArlappaKrishna AryalThor AspelundFelix AssahMaria Cecília F AssunçãoJuha AuvinenMária AvdićováAna AzevedoMohsen Azimi-NezhadFereidoun AziziMehrdad AzminBontha BabuSuhad BahijriNagalla BalakrishnaMohamed BamoshmooshMaciej BanachMaja BanadinovićPiotr BandoszJosé BanegasJoanna BaranCarlo BarbagalloAlberto BarcelóAmina BarkatMarta BarretoAluisio Jd BarrosMauro Virgílio Gomes BarrosAnna BartosiewiczAbdul BasitJoao Luiz D BastosIqbal BataAnwar BatiehaAssembekov BatyrbekLouise BaurRobert BeagleholeAntonisamy BelavendraHabiba Ben RomdhaneMikhail BenetLowell BensonSalim BerkinbayevAntonio Bernabe-OrtizGailute BernotieneHeloísa BettiolJorge BezerraAroor BhagyalaxmiSantosh BhargavaDaniel BiaKatia BiaschElysée Claude Bika LeleMukharram BikbovBihungum BistaPeter BjerregaardEspen 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JohanssonJari JokelainenJost JonasTorben JørgensenPradeep JoshiFarahnaz JoukarJacek JóżwiakAnne JuoleviGregor JurakVesna JurešaRudolf KaaksAnthony KafatosEero KajantieZhanna KalmatayevaNatasa KalpourtziOfra Kalter-LeiboviciFreja KampmannSrinivasan KannanEva KaraglaniLine KårhusKhem KarkiMarzieh KatibehJoanne KatzJussi KauhanenPrabhdeep KaurMaryam KavousiGyulli KazakbaevaUlrich KeilLital Keinan BokerSirkka Keinänen-KiukaanniemiRoya KelishadiHan Cg KemperMaryam KeramatiAlina KerimkulovaMathilde KerstingTimothy KeyYousef Saleh KhaderDavood KhaliliKay-Tee KhawBahareh KheiriMotahareh KheradmandAlireza KhosraviUrsula Kiechl-KohlendorferStefan KiechlJaphet KillewoDong Wook KimJeongseon KimHeidi KlakkMagdalena KlimekJurate KlumbieneMichael KnoflachElin KollePatrick KolsterenJukka KonttoRaija KorpelainenPaul KorrovitsJelena KosSeppo KoskinenKatsuyasu KoudaSudhir KowlessurSlawomir KozielJana KratenovaVilma KriaucionienePeter Lund KristensenSteiner KrokstadDaan KromhoutHerculina KrugerRuzena 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MohammadiZahra MohammadiNoushin MohammadifardReza MohammadpourhodkiViswanathan MohanSalim MohannaMuhammad Fadhli Mohd YusoffIraj MohebbiFarnam MohebiMarie MoitryLine MøllehaveDénes MolnárAmirabbas MomenanCharles MondoEric Monterrubio-FloresKotsedi Daniel K MonyekiJin Soo MoonMahmood MoosazadehLeila MoreiraAlain MorejonLuis MorenoKaren MorganGeorge MoschonisMalgorzata MossakowskaAya MostafaSeyed-Ali MostafaviJorge MotaMohammad Esmaeel MotlaghJorge MottaMarcos André Moura-Dos-SantosMalay MridhaKelias MsyambozaThet Thet MuAlfa MuhihiMaria MuiesanMartina Müller-NurasyidNeil MurphyJaakko MursuKamarul Imran MusaSanja Musić MilanovićVera MusilNorlaila MustafaIraj NabipourShohreh NaderimaghamGabriele NagelBalkish NaiduFarid NajafiHarunobu NakamuraJana NámešnáEi Ei K NangVinay NangiaSameer NarakeNdeye Coumba NdiayeWilliam NealAzim NejatizadehIlona NenkoMartin NeoviusChung NguyenNguyen NguyenQuang NguyenQuang Ngoc NguyenRamfis Nieto-MartínezTeemu NiiranenYury NikitinToshiharu NinomiyaSania NishtarMarina NjelekelaMarianna NoaleOscar NoboaAhmad Ali NoorbalaTeresa NoratMaria NordendahlBørge NordestgaardDavide NotoNatalia Nowak-SzczepanskaMohannad Al NsourBaltazar NunesTerence O'NeillDermot O'ReillyCaleb OchimanaEiji OdaAugustine OdiliKyungwon OhKumiko OharaRyutaro OhtsukaValérie OliéMaria Teresa A OlintoIsabel OliveiraMohd Azahadi OmarAltan OnatSok King OngLariane OnoPedro OrdunezRui OrnelasPedro OrtizClive OsmondSergej OstojicAfshin OstovarJohanna OteroKim OvervadEllis Owusu-DaboFred Michel PaccaudCristina PadezElena PahomovaKarina Mary De PaivaAndrzej PająkDomenico PalliLuigi PalmieriWen-Harn PanSonghomitra Panda-JonasFrancesco PanzaMariela PaoliDimitrios PapandreouSoon-Woo ParkSuyeon ParkWinsome ParnellMahboubeh ParsaeianPatrick PasquetNikhil PatelHalyna PavlyshynIvan PećinMangesh PednekarJoão PedroNasheeta PeerSergio Viana PeixotoMarkku PeltonenAlexandre PereiraKaren Gda PeresMarco PeresAnnette PetersJanina PetkevicieneNiloofar PeykariSon Thai PhamRafael PichardoIris PigeotHynek PikhartAida PilavLorenza PilottoFreda PitakakaAleksandra PiwonskaAndreia PizarroPedro Plans-RubióOzren PolašekMiquel PortaAnil PoudyalFarhad PourfarziAkram PourshamsHossein PoustchiRajendra PradeepaAlison PriceJacqueline PriceRui ProvidenciaSoile PuhakkaMaria PuiuMargus PunabRadwan QasrawiMostafa QorbaniDaniel QueirozTran Quoc BaoIvana RadićRicardas RadisauskasSalar RahimikazerooniMahfuzar RahmanOlli RaitakariManu RajEllina RakhimovaSudha Ramachandra RaoAmbady RamachandranElisabete RamosLekhraj RampalSanjay RampalDaniel Rangel ReinaVayia RarraCassiano Ricardo RechJosep RedonPaul Ferdinand M ReganitValéria RegecováLuis RevillaAbbas RezaianzadehRobespierre RibeiroElio RiboliAdrian RichterFernando RigoTobias Rinke de WitRaphael Ritti-DiasCynthia RobitailleFernando Rodríguez-ArtalejoMaría del Cristo Rodriguez-PerezLaura Rodríguez-VillamizarUlla RoggenbuckRosalba Rojas-MartinezDora RomagueraElisabetta RomeoAnnika RosengrenJoel Gr RoyAdolfo RubinsteinJean-Bernard RuidavetsBlanca Sandra Ruiz-BetancourtMaria Ruiz-CastellIuliia RusakovaPaola RussoMarcin RutkowskiCharumathi SabanayagamHamideh SabbaghiHarshpal SachdevAlireza SadjadiAli Reza SafarpourSare SafiSaeid SafiriOlfa SaidiSibel SakaryaNader SakiBenoit SalanaveEduardo Salazar MartinezDiego SalmerónVeikko SalomaaJukka SalonenMassimo SalvettiJose Sánchez-AbantoSusana SansDiana SantosIna SantosLèlita SantosMaria Paula SantosRute SantosJouko SaramiesLuis SardinhaGiselle SarganasNizal SarrafzadeganThirunavukkarasu SathishKai-Uwe SaumSavvas SavvaNorie SawadaMariana SbarainiMarcia ScazufcaBeatriz SchaanHerman SchargrodskySabine SchipfCarsten SchmidtPeter SchnohrBen SchöttkerSara SchrammConstance SchultszAletta SchutteSylvain SebertAye Aye SeinAbhijit SenIdowu SenbanjoSadaf SepanlouJennifer ServaisSvetlana ShalnovaTeresa Shamah-LevyMorteza ShamshirgaranCoimbatore Subramaniam ShanthiraniMaryam SharafkhahSanjib SharmaJonathan ShawAmaneh ShayanradAli Akbar ShayestehZumin ShiKenji ShibuyaHana Shimizu-FurusawaDong Wook ShinMajid ShiraniRahman ShiriNamuna ShresthaKhairil Si-RamleeAlfonso SianiRosalynn SiantarAbla SibaiCaroline Ramos de Moura SilvaDiego Augusto Santos SilvaMary SimonJudith SimonsLeon SimonsMichael SjöströmJolanta Slowikowska-HilczerPrzemyslaw SlusarczykLiam SmeethHung-Kwan SoFernanda Cunha SoaresEugène SobngwiStefan SöderbergAgustinus SoemantriReecha SofatVincenzo SolfrizziMohammad Hossein SomiEmily SonestedtYi SongThorkild Ia SørensenElin SørgjerdMaroje SorićCharles Sossa JéromeAïcha SoumaréBente Sparboe-NilsenKaren SparrenbergerJan StaessenGregor StarcBill StavreskiJostein Steene-JohannessenPeter StehleAryeh SteinGeorge StergiouJochanan StessmanJutta StieberDoris StöcklTanja StocksJakub StokwiszewskiKarien StronksMaria Wany StrufaldiMachi SukaChien-An SunYn-Tz SungPaibul SuriyawongpaisalRody SyHolly SyddallRené Charles SylvaMoyses SzkloE Shyong TaiMari-Liis TammesooAbdonas TamosiunasEng Joo TanXun TangFrank TanserYong TaoMohammed Rasoul TarawnehCarolina Tarqui-MamaniAnne TaylorJulie TaylorWilliam TebarGrethe TellTania TelloYih Chung ThamKr ThankappanHolger TheobaldXenophon TheodoridisLutgarde ThijsMikael ThinggaardNihal ThomasBarbara ThorandBetina ThuesenErik TimmermansDwi TjandrariniAnne TjonnelandUlla ToftHanna TolonenJanne TolstrupMurat TopbasRoman Topór-MadryMaría José TormoMichael TornaritisMaties TorrentLaura Torres-ColladoGiota TouloumiPierre TraissacAreti TriantafyllouDimitrios TrichopoulosAntonia TrichopoulouOanh Th TrinhAtul TrivediLechaba TshepoShoichiro TsuganeAzaliia TuliakovaMarshall Tulloch-ReidFikru TulluTomi-Pekka TuomainenJaakko TuomilehtoMaria TurleyGilad TwigPer TyneliusChristophe TzourioPeter UedaEunice UgelHanno UlmerHannu Mt UusitaloGonzalo ValdiviaDamaskini ValviRob van DamBert-Jan van den BornJohan van Der HeydenYvonne van Der SchouwKoen van HerckHoang van MinhNatasja van SchoorIrene Gm van ValkengoedElisabeth van ZutphenDirk VanderschuerenDiego VanuzzoAnette VarboSenthil VasanTomas VegaToomas VeidebaumGustavo Velasquez-MelendezGiovanni VeronesiWm Monique VerschurenRoosmarijn VerstraetenCesar VictoraLucie VietSalvador VillalpandoPaolo VineisJesus VioqueJyrki VirtanenSophie Visvikis-SiestBharathi ViswanathanTiina VlasoffPeter VollenweiderAri VoutilainenAlisha WadeJanette WaltonElvis Oa WambiyaWan Mohamad Wan BebakarWan Nazaimoon Wan MohamudRildo de Souza Wanderley JúniorMing-Dong WangNingli WangQian WangXiangjun WangYa Xing WangYing-Wei WangS Goya WannametheeNicholas WarehamWenbin WeiAneta WeresBo WernerPeter WhincupKurt WidhalmAndrzej WiecekRainford WilksJohann WilleitPeter WilleitEmmanuel WilliamsTom WilsgaardBogdan WojtyniakRoy Wong-McclureAndrew WongTien Yin WongJean WooFrederick WuShouling WuJustyna WyszynskaHaiquan XuLiang XuNor Azwany YaacobWeili YanLing YangXiaoguang YangD.M. WysockiTabara YasuharuXingwang YePanayiotis YiallourosMoein YoosefiAkihiro YoshiharaSan-Lin YouNovie Younger-ColemanAhmad Faudzi YusoffAhmad ZainuddinSeyed Rasoul ZakaviFarhad ZamaniSabina ZambonAntonis ZampelasMaria Elisa ZapataKo Ko ZawKristyna ZejglicovaTajana Zeljkovic VrkicYi ZengLuxia ZhangZhen-Yu ZhangDong ZhaoMing-Hui ZhaoShiqi ZhenYingfeng ZhengBekbolat ZholdinDan ZhuMarie ZinsEmanuel ZittYanina ZocaloNada ZoghlamiJulio Zuñiga CisnerosMajid Ezzati
• Organismes : Imperial College London Imperial College London Harvard T.H. Chan School of Public Health WHO-TDR Suisse University of California [Berkeley] Imperial College London Imperial College London Imperial College London Imperial College London Imperial College London Imperial College London Imperial College London Imperial College London WHO-TDR Suisse WHO-TDR Suisse University of New South Wales [Sydney] Imperial College London Almazov National Medical Research Centre (St. Petersburg) Charles University, Faculty of Education [Prague] Éco-Anthropologie Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre Hospitalier Universitaire de Toulouse Éco-Anthropologie Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre Hospitalier Universitaire de Toulouse Cohortes épidémiologiques en population Université Paris Cité Universitas Indonesia Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Éco-Anthropologie Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire Cohortes épidémiologiques en population Université Paris Cité
• Publié dans The Lancet le 02/11/2020

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Résumé : BACKGROUND - Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS - We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS - The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION - Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings.

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Fichiers liés : 1-s2.0-S0140673621013301-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/09/2021
• Auteurs : Lenneke HaasAriane BoumendilHans FlaattenBertrand GuidetMercedes IbarzChristian JungRui MorenoAlessandro MorandiFinn AndersenTilemachos ZafeiridisSten WaltherSandra OeyenSusannah LeaverXimena WatsonCarole BoulangerWojciech SzczeklikJoerg SchefoldMaurizio CecconiBrian MarshMichael JoannidisYuriy NalapkoMuhammed ElhadiJesper FjølnerAntonio ArtigasDylan de LangeMichael JoannidisPhilipp EllerRaimund HelbokRené SchmutzJoke NolletNikolaas de NevePieter de BuysscherSandra OeyenWalter SwinnenMarijana MikačićAnders BastiansenAndreas HustedBård DahleChristine CramerChristoffer SøllingDorthe ØrsnesJakob Edelberg ThomsenJonas Juul PedersenMathilde Hummelmose EnevoldsenThomas ElkmannAgnieszka Kubisz-PudelkoAlan PopeAmy CollinsAshok RajCarole BoulangerChristian FreyCiaran HartClare BolgerDominic SprayGeorgina RandellHelder FilipeIngeborg WeltersIrina GrecuJane EvansJason CupittJenny LordJeremy HenningJoanne JonesJonathan BallJulie NorthKiran SalaunkeyLaura Ortiz-Ruiz de GordoaLouise BellMadhu BalasubramaniamMarcela VizcaychipiMaria FaulknerMcdonald MupudziMegan Lea-HagertyMichael ReayMichael SpiveyNicholas LoveNick Spittle Nick SpittleNigel WhitePatricia WilliamsPatrick MorganPhillipa WakefieldRachel SavineReni JacobRichard InnesRitoo KapoorSally HumphreysSteve RoseSusan DowlingSusannah LeaverTarkeshwari ManeTom LawtonVongayi OgbeideWaqas KhaliqYolanda BairdAntoine RomenArnaud GalboisBertrand GuidetChristophe VinsonneauCyril CharronDidier TheveninEmmanuel GuerotGuillaume BeschGuillaume SavaryHervé MentecJean-Luc ChagnonJean-Philippe RigaudJean-Pierre QuenotJeremy CastanerayJérémy RosmanJulien MaizelKelly TierceletLucie VettorettiMaud Mousset HovaereMessika MessikaMichel DjibréNathalie RolinPhilippe BurtinPierre GarconSaad NseirXavier ValetteChristian RabeEberhard BarthHenning EbeltKristina FuestMarcus FranzMichael HoracekMichael SchusterPatrick MeybohmRaphael Romano BrunoSebastian AllgäuerSimon DublerStefan SchallerStefan ScheringStephan SteinerThorben DieckTim RahmelTobias GrafAnastasia KoutsikouAristeidis VakalosBogdan RaitsiouElli Niki FlioniEvangelia NeouFotios TsimpoukasGeorgios PapathanakosGiorgos MarinakisIoannis KoutsodimitropoulosKounougeri AikateriniNikoletta RovinaStylliani KoureleaTasioudis PolychronisVasiiios ZidianakisVryza KonstantiniaZoi AidoniBrian MarshCatherine MotherwayChris ReadIgnacio Martin-LoechesAndrea Neville CracchioloAristide MorigiItalo CalamaiStefania BrusaAhmed ElhadiAhmed TarekAla KhaledHazem AhmedWesal Ali BelkhairAlexander CornetDiederik GommersDylan de LangeEva van BovenJasper HaringmanLenneke HaasLettie van den BergOscar HoitingPeter de JagerRik GerritsenTom DormansWillem DieperinkAlena Breidablik Alena BreidablikAnita SlapgardAnne-Karin RimeBente JannestadBritt SjøbøeEva RiceFinn AndersenHans Frank StrietzelJan Peter JensenJørund LangørgenKirsti TøienKristian StrandMichael HahnPål KlepstadAleksandra BiernackaAnna KluzikBartosz KudlinskiDariusz MaciejewskiDorota StudzińskaHubert HymczakJan StefaniakJoanna Solek-PastuszkaJoanna ZorskaKatarzyna CwylLukasz KrzychMaciej ZukowskiMałgorzata Lipińska-GedigaMarek PietruszkoMariusz PiechotaMarta SerwaMiroslaw CzuczwarMirosław ZiętkiewiczNatalia KozeraPaweł NasiłowskiPaweł SendurPaweł ZatorskiPiotr GalkinRyszard GawdaUrszula KościuczukWaldemar CyrankiewiczWojciech GolaAlexandre Fernandes PintoAna Margarida FernandesAna Rita SantosCristina SousaInês BarrosIsabel Amorim FerreiraJacobo Bacariza BlancoJoão Teles CarvalhoJose MaiaNuno CandeiasNuno CatorzeVladislav BelskiyAfrica LoresAngela Prado MiraCatia CillonizDavid Perez-TorresEmilio MasedaEnver RodriguezEstefania Prol-SilvaGaspar EixarchGemma GomàGerardo AguilarGonzalo Navarro VelascoMarián Irazábal JaimesMercedes Ibarz VillamayorNoemí Llamas FernándezPatricia Jimeno CuberoSonia López-CuencaTeresa TomasaAnders SjöqvistCamilla BrorssonFredrik SchiölerHenrik WestbergJessica NauskaJoakim SivikJohan BerkiusKarin Kleiven ThiringerLina de GeerSten WaltherFilippo BoroliJoerg SchefoldLeila HergafiPhilippe EckertIsmail YıldızIhor YovenkoYuriy NalapkoYuriy NalapkoRichard Pugh
• Organismes : CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517
• Publié dans Age and Ageing le 27/10/2020

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Résumé : Abstract Background Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear. Objective To investigate both the short- and long-term mortality of VIPs admitted with sepsis and assess the relation of mortality with pre-existing physical and cognitive function. Design Prospective cohort study. Setting 241 ICUs from 22 European countries in a six-month period between May 2018 and May 2019. Subjects Acutely admitted ICU patients aged ≥80 years with sequential organ failure assessment (SOFA) score ≥ 2. Methods Sepsis was defined according to the sepsis 3.0 criteria. Patients with sepsis as an admission diagnosis were compared with other acutely admitted patients. In addition to patients’ characteristics, disease severity, information about comorbidity and polypharmacy and pre-existing physical and cognitive function were collected. Results Out of 3,596 acutely admitted VIPs with SOFA score ≥ 2, a group of 532 patients with sepsis were compared to other admissions. Predictors for 6-month mortality were age (per 5 years): Hazard ratio (HR, 1.16 (95% confidence interval (CI), 1.09–1.25, P < 0.0001), SOFA (per one-point): HR, 1.16 (95% CI, 1.14–1.17, P < 0.0001) and frailty (CFS > 4): HR, 1.34 (95% CI, 1.18–1.51, P < 0.0001). Conclusions There is substantial long-term mortality in VIPs admitted with sepsis. Frailty, age and disease severity were identified as predictors of long-term mortality in VIPs admitted with sepsis.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/09/2021
• Auteurs : Yann LelongeAlexandre KarkasRoland PeyronPierre ReynardPhilippe ConversPierre Bertholon
• Organismes : Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Service de Neurologie [CHU de Saint-Étienne] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Central Integration of Pain in Human Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
• Publié dans Otology and Neurotology le 02/11/2020

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Résumé : Introduction: Tumarkin first described drop attacks (DA) in patients with a peripheral vestibular syndrome and speculated the role of a mechanical deformation of the otolith organs. We emphasized on the possible occurrence of vertigo/dizziness after a DA. In the light of the oculomotor examination of one patient right after the DA, we discussed on the mechanisms. We also described the management of DA. Material and Method: This study included patients with definite Menière's disease (MD) and at least one DA without associated neurological symptoms. Patients with vertigo/dizziness after the fall were not excluded. Results: Fifteen patients with MD complained of DA that was complicated either by severe head trauma (n = 1) or various fractures (n = 4). Seven patients complained of vertigo/dizziness after the DA. In one patient, DA occurred in the waiting room with a vertical illusion of movement immediately after the fall and a predominant down beating nystagmus that later changed direction. Follow up was favorable in all patients after oral medication alone (n = 7), chemical labyrinthectomy (n = 7) or vestibular neurotomy (n = 1). Conclusions: We suggest that a subset of patients with MD can complain of vertigo after a DA. We conclude on the possible occurrence of a vertical mainly down beating nystagmus in MD. Since this latter nystagmus is likely related to a semicircular canal rather than an otolith dysfunction, we discuss on the mechanisms of DA followed by vertigo/dizziness. Due to the risk of trauma in DA, chemical labyrinthectomy is a reasonable and effective option although spontaneous remission is possible.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 08/09/2021
• Auteurs : Stephane BoulakiaHoà Tran QuocOlivier HussonPhilippe LienardOumarou BalarabéFlorent TivetJean-Pierre Sarthou
• Organismes : Agroécologie et intensification durables des cultures annuelles Fonctionnement écologique et gestion durable des agrosystèmes bananiers et ananas Agroécologie et intensification durables des cultures annuelles Agroécologie et intensification durables des cultures annuelles Agroécologie et intensification durables des cultures annuelles Agroécologie et intensification durables des cultures annuelles AGroécologie, Innovations, teRritoires

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Résumé : Description of the practice: Conservation Agriculture (CA) regroups a vast diversity of agroecological cropping systems characterized by the simultaneous and continuous application of 3 practical principles: i. No-Tillage, i.e. minimum mechanical soil disturbance with direct seeding, no-till weeding and minimum soil disturbance with other operations, including harvest. The FAO definition specifies that “the disturbed area must be less than 15 cm wide or less than 25 percent of the cropped area (whichever is lower). Mechanical disturbance should be limited to the purpose of placing seed or fertilizer”; ii. Permanent soil organic cover with crop residues and/or cover crops to the extent allowed by water availability. Ground cover measured immediately after the seeding operation should have over 30 percent cover; iii. Species diversification through varied crop sequences and associations involving at least three different crops.

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Fichiers liés : cb6595en.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/09/2021
• Auteurs : Sigrid Le ClercLaura LombardiBernhard T BauneAzmeraw T AmareKlaus Oliver SchubertLiping HouScott R ClarkSergi PapiolMicah CearnsUrs HeilbronnerFranziska DegenhardtFasil Tekola-AyeleYi-Hsiang HsuTatyana ShekhtmanMazda AdliNirmala AkulaKazufumi AkiyamaRaffaella ArdauBárbara AriasJean-Michel AubryLena BacklundAbesh Kumar BhattacharjeeFrank BellivierAntonio BenabarreSusanne BengesserJoanna M BiernackaArmin BirnerClara Brichant-PetitjeanPablo CervantesHsi-Chung ChenCaterina ChillottiSven CichonCristiana CruceanuPiotr M CzerskiNina DalknerAlexandre DayerMaria Del ZompoJ. Raymond Raymond DepauloB EtainStéphane JamainPeter FalkaiAndreas J ForstnerLouise FrisenMark A FryeJanice M FullertonSébastien GardJulie S GarnhamFernando S GoesMaria Grigoroiu-SerbanescuPaul GrofRyota HashimotoJoanna HauserStefan HermsPer HoffmannEsther JiménezJean-Pierre KahnLayla KassemPo-Hsiu KuoTadafumi KatoJohn R KelsoeSarah Kittel-SchneiderEwa Ferensztajn-RochowiakBarbara KönigIchiro KusumiGonzalo LajeMikael LandénCatharina LavebrattSusan G LeckbandAlfonso TortorellaMirko ManchiaLina MartinssonMichael J MccarthySusan L McelroyFrancesc ColomVincent MillischerMarina MitjansFrancis M MondimorePalmiero MonteleoneCaroline M NievergeltMarkus M NöthenTomas NovákClaire O’donovanNorio OzakiUrban ÖsbyAndrea PfennigJames B PotashAndreas ReifEva ReininghausGuy RouleauJanusz K RybakowskiMartin SchallingPeter R SchofieldBarbara W SchweizerGiovanni SeverinoPaul D ShillingKatzutaka ShimodaChristian SimhandlClaire M SlaneyClaudia PisanuAlessio SquassinaThomas StammPavla StopkovaMario MajGustavo TureckiEduard VietaJulia VeehStephanie H WittAdam WrightPeter P ZandiPhilip B MitchellMichael BauerMartin AldaMarcella RietschelFrancis J McmahonThomas G SchulzeJean-Louis SpadoniWahid BoukouaciJean-Romain RichardP. Le CorvoisierCaroline BarrauJean-François ZaguryMarion LeboyerRyad Tamouza
• Organismes : Laboratoire Génomique, bioinformatique et chimie moléculaire CHU Henri Mondor [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] Westfälische Wilhelms-Universität Münster = University of Münster = Université de Münster [Münster, Allemagne] Melbourne Medical School [Melbourne] The Florey Institute of Neuroscience and Mental Health University of Adelaide University of Adelaide National Institutes of Health [Bethesda, MD, USA] University of Adelaide Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München University of Adelaide Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München Institut für Genetik - Universität Bonn / Institute of Genetics - University of Bonn Optimisation thérapeutique en Neuropsychopharmacologie Optimisation thérapeutique en Neuropsychopharmacologie Optimisation thérapeutique en Neuropsychopharmacologie Laboratoire Génomique, bioinformatique et chimie moléculaire Laboratoire Génomique, bioinformatique et chimie moléculaire IMRB - "Neuropsychiatrie translationnelle" [Créteil] CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil]
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1*11:01 classical allele, associated with a better response to Li ( p < 1 × 10 −3 ; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response.

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Fichiers liés : s41598-021-97140-7.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/09/2021
• Auteurs : Loïc SalmonPierre-Yves PillainGoulven GuillouJean-Philippe Babau
• Organismes : Lab-STICC_UBO_CACS_MOCS Lab-STICC_UBO_CACS_MOCS

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/09/2021
• Auteurs : Loïc SalmonPierre-Yves PillainGoulven GuillouJean-Philippe Babau
• Organismes : Knowledge Learning and Information Modelling Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance

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Résumé : One key objective of Cyber-Physical System (CPS) simulation is to evaluate different CPS configurations regarding a certain user objective. First, simulation of CPS necessitates frameworks to handle heterogeneity of CPS components (the software and hardware system control, the behavior of the CPS itself and its physical environment). Then, to build simulators, designers use paradigms like FMI (Functional Mock-Up Interface) that proposes a data-driven generic interface facilitating the integration of heterogeneous models. However, in order to facilitate simulation configuration, an approach is required to drive modeling of parametric features and operational conditions. In this paper, we present CARES, a component-based and modeldriven approach to facilitate CPS simulation. CARES is applied to evaluate an Autonomous Underwater Vehicle (AUV) navigation function by simulation. The proposed models integrate both the principles of a generic simulation (integration of Component Based Software Engineering CBSE concepts and FMI paradigm) and domain specific aspects through a component-based architecture style. From a design model, a code generator builds the structural (Java or C++) code of the simulator. The generated code relies on a given run-time library for its execution and its structure facilitates integration of domain-specific code. The experiments show the effectiveness of the approach to build simulators for evaluation of different AUV configurations.

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Fichiers liés : FDL21_paper_6 (2).pdf

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