Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Francis BessièreKévin GardeyAbdeslam BouzemanGuillaume DuthoitLinda KoutbiFabien LabombardaChristelle MarquiéJean-Baptiste GourraudPierre MondolyJean Marc SellalPierre BordacharAlexis HermidaFrédéric AnselmeAnouk AsselinCaroline AudinetYvette BernardSerge BovedaPhilippe ChevalierGael ClericiAntoine da CostaMaxime de GuillebonPascal DefayeRomain EschalierRodrigue GarciaCharles GuenanciaBenoit Guy-MoyatRoland HenaineDidier IrlesLaurence IserinFrançois JourdaMagalie LadouceurPhilippe LagrangeMikael LaredoJacques MansouratiGrégoire MassouliéAmel MathironPhilippe MauryCédric NguyenSandro NinniMarie-Cécile PerierBertrand PierreFrédéric SacherCamille WaltonPierre WinumRaphaël P MartinsJean-Luc PasquiéJean Benoit ThamboXavier JouvenNicolas CombesSylvie Di FilippoEloi MarijonVictor Waldmann
• Organismes : Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] CHU Pitié-Salpêtrière [AP-HP] Hôpital de la Timone [CHU - APHM] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Toulouse Imagerie Adaptative Diagnostique et Interventionnelle Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Bordeaux CHU Amiens-Picardie CHU Rouen Paris-Centre de Recherche Cardiovasculaire Groupe Hospitalier Bretagne Sud Centre Hospitalier Régional Universitaire de Besançon Clinique Pasteur [Toulouse] Hôpital Louis Pradel [CHU - HCL] CHU Sud Saint Pierre [Ile de la Réunion] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre hospitalier de Pau Centre Hospitalier Universitaire [CHU Grenoble] CHU Clermont-Ferrand Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU Dijon CHU Limoges Hôpital Louis Pradel [CHU - HCL] Hôpital Européen Georges Pompidou [APHP] Paris-Centre de Recherche Cardiovasculaire CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques CHU Clermont-Ferrand CHU Amiens-Picardie Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Chalon-sur-Saône William Morey Centre Hospitalier Régional Universitaire [CHU Lille] Paris-Centre de Recherche Cardiovasculaire Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire de Bordeaux Hôpital Louis Pradel [CHU - HCL] Centre Hospitalier Universitaire de Nîmes Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Bordeaux Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Louis Pradel [CHU - HCL] Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire
• Publié dans JACC: Clinical Electrophysiology le 31/10/2020

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Résumé : Objectives: This study aimed to assess the impact of pulmonary valve replacement (PVR) on ventricular arrhythmias burden in a population of tetralogy of Fallot (TOF) patients with continuous cardiac monitoring by implantable cardioverter-defibrillators (ICDs). Background: Sudden cardiac death is a major cause of death in TOF, and right ventricular overload is commonly considered to be a potential trigger for ventricular arrhythmias. Methods: Data were analyzed from a nationwide French ongoing study (DAI-T4F) including all TOF patients with an ICD since 2000. Survival data with recurrent events were used to compare the burden of appropriate ICD therapies before and after PVR in patients who underwent PVR over the study period. Results: A total of 165 patients (mean age 42.2 ± 13.3 years, 70.1% male) were included from 40 centers. Over a median follow-up period of 6.8 (interquartile range: 2.5 to 11.4) years, 26 patients (15.8%) underwent PVR. Among those patients, 18 (69.2%) experienced at least 1 appropriate ICD therapy. When considering all ICD therapies delivered before (n = 62) and after (n = 16) PVR, the burden of appropriate ICD therapies was significantly lower after PVR (HR: 0.21; 95% confidence interval [CI]: 0.08 to 0.56; p = 0.002). Respective appropriate ICD therapies rates per 100 person-years were 44.0 (95% CI: 35.7 to 52.5) before and 13.2 (95% CI: 7.7 to 20.5) after PVR (p < 0.001). In the overall cohort, PVR before ICD implantation was also independently associated with a lower risk of appropriate ICD therapy in primary prevention patients (HR: 0.29 [95% CI: 0.10 to 0.89]; p = 0.031). Conclusions: In this cohort of high-risk TOF patients implanted with an ICD, the burden of appropriate ICD therapies was significantly reduced after PVR. While optimal indications and timing for PVR are debated, these findings suggest the importance of considering ventricular arrhythmias in the overall decision-making process. (French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator [DAI-T4F]; NCT03837574).

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Fichiers liés : 2021 Bessiere et al., Impact.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Claire BouletiMorgane MichelAntoine Jobbe DuvalThibaut HemeryPierre-Philippe NicolRomain DidierFloriane ZeyonsOualid ZouaghiDidier TchetcheClemence DelonMaxence DelomezAlain DibieDavid AttiasHerve Le BretonBertrand CormierJean-Francois ObadiaChristophe TribouilloyEmmanuel LansacKarine ChevreulNicole NaccacheHelene EltchaninoffMartine GilardBernard Iung
• Organismes : Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables Endothélium, valvulopathies et insuffisance cardiaque CHU Rouen Hôpital de la Cavale Blanche Service de cardiologie [Brest] Hôpitaux Universitaires de Strasbourg Clinique Pasteur [Toulouse] Institut Mutualiste de Montsouris Clinique Pasteur [Toulouse] Laboratoire Traitement du Signal et de l'Image Hôpital Privé Jacques Cartier [Massy] Hospices Civils de Lyon Université de Picardie Jules Verne Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Institut Mutualiste de Montsouris Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables Département de la Recherche Clinique et du Développement [AP-HP Hôtel Dieu] Endothélium, valvulopathies et insuffisance cardiaque CHU Rouen Optimisation des régulations physiologiques Laboratoire de Recherche Vasculaire Translationnelle
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : Background. - According to the guidelines, surgical aortic valve replacement (SAVR) is recommended in patients at low surgical risk (EuroSCORE II < 4%), whereas for other patients, the decision between transcatheter aortic valve implantation (TAVI) and surgery should be made by the Heart Team, with TAVI being favoured in elderly patients. Aim. - The RAC prospective multicentre survey assessed the respective contributions of age and surgical risk scores in therapeutic decision making in elderly patients with severe symptomatic aortic stenosis. Methods. - In September and October 2016, 1049 consecutive patients aged >= 75 years were included in 32 centres with on-site TAVI and surgical facilities. The primary endpoint was the decision between medical management, TAVI or SAVR. Results. - Mean age was 84 +/- 5 years and 53% of patients were female. The surgical risk was classified as high (EuroSCORE II > 8%) in 18% of patients, intermediate (EuroSCORE II 4-8%) in 34% and low (EuroSCORE II <= 4%) in 48%. TAVI was preferred in 71% of patients, SAVR in 19% and medical treatment in 10%. The choice of TAVI over SAVR was associated with older age (P < 0.0001) and a higher EuroSCORE II (P = 0.008). However, the weight of EuroSCORE II in therapeutic decision making markedly decreased after the age of 80 years. Indeed, 77% of patients aged >= 80 years were referred for TAVI, despite a low estimated surgical risk. Conclusions. - The impact of risk scores depends strongly on age, and decreases considerably after 80 years, most patients being referred for TAVI, independent of their estimated surgical risk. Despite medical advancements, 10% of patients were still denied any intervention. (C) 2021 Elsevier Masson SAS. All rights reserved.

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Fichiers liés : S1875213621001352.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Jean-Marie UrienChristophe CamusChristophe LeclercqLoren DejoiesPhilippe MaboRaphaël P MartinsSarrah BoukthirFrançois BénézitNathalie BeharMatthieu RevestSylvain BodiJulien BilaErwan DonalPierre Tattevin
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
• Publié dans Infection le 27/10/2020

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Résumé : BACKGROUND: Increasing use of cardiovascular implantable electronic devices (CIED), as permanent pacemakers (PPM), implantable cardioverter defibrillators (ICD), or cardiac resynchronization therapy (CRT), is associated with the emergence of CIED-related infective endocarditis (CIED-IE). We aimed to characterize CIED-IE profile, temporal trends, and prognostic factors. METHODS: CIED-IE diagnosed at Rennes University Hospital during years 1992-2017 were identified through computerized database, and included if they presented all of the following: (1) clinical signs of infection; (2) microbiological documentation through blood and/or CIED lead cultures; (3) lead or valve vegetation, or definite IE according to Duke criteria. Data were retrospectively extracted from medical charts. The cohort was categorized in three periods: 1992-1999, 2000-2008, and 2009-2017. RESULTS: We included 199 patients (51 women, 148 men, median age 73 years [interquartile range, 64-79]), with CIED-IE: 158 PPMs (79%), 24 ICD (12%), and 17 CRT (9%). Main pathogens were coagulase-negative staphylococci (CoNS: n = 86, 43%), Staphylococcus aureus (n = 60, 30%), and other Gram-positive cocci (n = 28, 14%). Temporal trends were remarkable for the decline in CoNS (P = 0.002), and the emergence of S. aureus as the primary cause of CIED-IE (24/63 in 2009-2017, 38%). Factors independently associated with one-year mortality were chronic obstructive pulmonary disease (COPD: hazard ratio 3.84 [1.03-6.02], P = 0.03), left-sided endocarditis (HR 2.25 [1.09-4.65], P = 0.03), pathogens other than CoNS (HR 3.16 [1.19-8.39], P = 0.02), and CIED removal/reimplantation (HR 0.41 [0.20-0.83], P = 0.01). CONCLUSIONS: S. aureus has emerged as the primary cause of CIED-IE. Left-sided endocarditis, COPD, pathogens other than CoNS, and no CIED removal/reimplantation are independent risk factors for one-year mortality.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Mohammad AnadaniGaultier MarnatArturo ConsoliPanagiotis PapanagiotouRaul NogueiraAlejandro SpiottaRomain BourcierMaéva KyhengJulien LabreucheAdnan SiddiquiMarc RiboAdam de HavenonUrs FischerIgor SibonCyril DargazanliCaroline ArquizanChristophe CognardJean Marc OlivotRené AnxionnatGérard AudibertMikael MazighiRaphaël BlancBertrand LapergueSébastien RichardBenjamin GoryFrancis TurjmanMichel P. PiotinHenrik Steglich-ArnholmMarkus HoltmannspötterChristian TaschnerSebastian EidenDiogo C. HaussenWaqas MuhammadMaria BoutchakovaFranziska DornMonika Killer-OberpfalzerSalvatore MangiaficoMarios-Nikos PsychogiosMarc-Antoine LabeyrieAlessandra BiondiSerge BracardJonathan Andrew GrossbergAdrien GuenegoJulien DarcourtIsabelle VukasinovicElisa PomeroJason DaviesLeonardo RenieriCorentin HeckerMaria Muchada MuchadaGeorges RodeschEmmanuel HoudartJohanna LockauAndreas KastrupHocine RedjemDaniel BehmeHussain ShallwaniMaurer ChristopherGioia MioneLisa HumbertjeanNolwenn Riou-ComteFrançois ZhuAnne-Laure BorderelleLiang LiaoSimon EscalardJean-Philippes DesillesGabriele CiccioStanislas SmajdaMikael ObadiaCandice SabbenOvide CorabianuThomas de BrouckerDidier SmadjaSonia AlamowitchOlivier IlleÉric ManchonPierre-Yves GarciaGuillaume TaylorMalek Ben MaachaAdrien WangS. EvrardMaya TchikviladzeNadia AjiliDavid WeisenburgerLucas GorzaOguzhan CoskunFederico Di MariaGeorges RodeshMorgan LeguenJulie GratieuxFernando PicoHaja RakotoharinandrasanaPhilippe TassanRoxanna PollSylvie MarinierFlorent GarielXavier BarreauJérôme BergeLouis VeunacPatrice MenegonLudovic LucasStéphane OlindoPauline RenouSharmila SagnierMathilde PoliSabrina DebruxellesThomas TourdiasJean-Sébastien LiegeyBenjamin Daumas-DuportPierre-Louis AlexandreMonica RoyCédric LenobleVincent L'AllinecJean-Baptiste GirotHubert DesalMarc BraunAnne-Laure DerelleRomain TonneletEmmanuelle SchmittSophie PlanelJean-Christophe LacourGabriela HossuMarine BeaumontMitchelle BailangMarie ReitterAgnès MassonLionel AlbAdriana TabarnaMarcela VoicuIona PodarMadalina BrezeanuVincent CostalatGregory GascouPierre-Henri LefevreImad DerrazCarlos RiquelmeNicolas GaillardIsabelle MourandLucas Corti
• Organismes : Washington University School of Medicine in St. Louis Medical University of South Carolina [Charleston] Département de Neuro-Radiologie [Bordeaux] Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch] National and Kapodistrian University of Athens Emory University School of Medicine Medical University of South Carolina [Charleston] Nantes Université - pôle Santé Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Evaluation des technologies de santé et des pratiques médicales - ULR 2694 University at Buffalo [SUNY] Vall d'Hebron University Hospital [Barcelona] University of Utah Inselspital Bern Service de neurologie [Bordeaux] Neuroradiologie [Hôpital Gui de Chauliac] Neurochirurgie [Hôpital Gui de Chauliac] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Département de Neurologie [Toulouse] Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Centre Hospitalier Régional Universitaire de Nancy CHU Rothschild [AP-HP] CHU Rothschild [AP-HP] Hôpital Foch [Suresnes] UFR Sciences de la santé Simone Veil Service de neurologie [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle
• Publié dans Journal of Neurointerventional Surgery le 26/10/2020

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Résumé : Background Endovascular therapy (EVT) is effective and safe in patients with tandem occlusion. The benefit of intravenous thrombolysis (IVT) prior to EVT in acute tandem occlusion is debatable. Objective To compare EVT alone with EVT plus IVT in patients with acute ischemic stroke due to anterior circulation tandem occlusions. Methods This is an individual patient pooled analysis of the Thrombectomy In TANdem lesions (TITAN) and Endovascular Treatment in Ischemic Stroke (ETIS) Registries. Patients were divided into two groups based on prior IVT treatment: (1) IVT+ group, which included patients who received IVT prior to EVT, (2) IVT− group, which included patients who did not receive IVT prior to EVT. Propensity score (inverse probability of treatment weighting (IPTW)) was used to reduce baseline between-group differences. The primary outcome was favorable outcome—that is, modified Rankin Scale (mRS) score 0 to 2 at 90 days. Results Overall, 602 consecutive patients with an acute stroke with tandem occlusion were included (380 and 222 in the bridging therapy and EVT alone groups, respectively). Onset to imaging time was shorter in the IVT+ group (median 103 vs 140 min). In contrast, imaging to puncture time was longer in the IVT+ group (median 107 vs 91 min). In IPTW analysis, the IVT+ group had higher odds of favorable outcome, excellent outcome (90-day mRS score 0–1), and successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b/3 at the end of EVT). There was no difference in the risk of significant hemorrhagic complications between groups. In secondary analysis of patients treated with acute cervical internal carotid artery stenting, bridging therapy was associated with higher odds of favorable outcome and lower odds of mortality at 90 days. Conclusions Our results suggest that bridging therapy in patients with acute ischemic stroke due to anterior tandem occlusion is safe and may improve functional outcome, even in the setting of acute cervical internal carotid artery stenting during EVT.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Sandrine CaputoLisa GolmardMélanie LéoneFrancesca DamiolaMarine Guillaud-BatailleFrançoise RevillionEtienne RouleauNicolas DeriveAdrien BuissonNoémie BassetMathias SchwartzPaul VilquinCeline GarrecMaud PrivatMathilde Gay-BellileCaroline AbadieKhadija AbidallahFabrice AiraudAnne-Sophie AllaryEmmanuelle Barouk-SimonetMuriel BelottiCharlotte BenigniPatrick BenusiglioChristelle BertheminPascaline BerthetOphelie BertrandStéphane BézieauMarie BidartYves-Jean BignonAnne-Marie BirotMaud BlanluetAmelie BloucardJohny BombledValerie BonadonaFrançoise BonnetMarie-Noëlle Bonnet-DupeyronManon BoulaireFlavie BoulouardAhmed BourasViolaine BourdonAfane BrahimiFanny BrayotelBrigitte Bressac de PailleretsNoémie BronnecVirginie BubienBruno BuecherOdile CabaretJennifer CarriereJean ChiesaStephanie Chieze-ValéroCamille CohenOdile Cohen-HaguenauerChrystelle ColasMarie-Agnès Collonge-RameAnne-Laure ConoyFlorence CouletIsabelle CoupierLouise CrivelliVéronica CusinAntoine de PauwCatherine DehainaultHélène DelhomelleCapucine DelnatteSophie DemontetyPhilippe DenizeauPierre DevulderHelene DreyfusCatherine Dubois D’engheinAnaïs DupréAnne DurlachSophie DussartAnne FajacSamira FekairiSandra Fert-FerrerAlice FiévetRobin FouilletEmmanuelle Mouret-FourmeMarion Gauthier-VillarsPaul GestaSophie GiraudLaurence GladieffVeronica GoldbargVincent GoussotVirginie GuibertErell GuillermChristophe GuyAgnès HardouinCéline HeudeClaude HoudayerOlivier IngsterCaroline Jacquot-SawkaNatalie JonesSophie KriegerSofiane LacosteHakima LallaouiHelene LarbreAnthony LaugéGabrielle Le GuyadecMarine Le MentecCaroline LecerfJessica Le GallBérengère LegendreClémentine LegrandAngélina LegrosSophie LejeuneRosette LidereauNorbert LignonJean-Marc LimacherSarab LizardMichel LongyAlain LortholaryPierre MacquereAudrey MailliezSarah MalsaHenri MargotVéronique MariChristine MaugardCindy MeiraJulie MenjardDiane MolièreVirginie MoncoutierJessica Moretta-SerraEtienne MullerZoe NevièreThien-Vu Nguyen Minh TuanTetsuro NoguchiCatherine NoguèsFlorine OcaCornel PopoviciFabienne PrieurSabine RaadJean-Marc ReyAgathe RicouLucie SalleClaire SauleNicolas SevenetFatoumata SimagaHagay SobolVoreak SuybengIsabelle TennevetHenrique TenreiroJulie TinatChristine ToulasIsabelle TurbiezNancy UhrhammerPierre Vande PerreDominique VaurLaurence VenatNicolas ViellardMarie-Charlotte VillyMathilde WarcoinAlice YvardHelene ZattaraOlivier CaronChristine LassetAudrey RemenierasNadia Boutry-KryzaLaurent CastéraDominique Stoppa-Lyonnet
• Organismes : Service de Génétique Oncologique Université Paris Sciences et Lettres Département de Biologie des Tumeurs Unité de génétique et biologie des cancers Hospices Civils de Lyon Centre Léon Bérard [Lyon] CHU Pitié-Salpêtrière [AP-HP] Institut Gustave Roussy Génétique (Biologie pathologie) Institut de biochimie et génétique cellulaires Centre Léon Bérard [Lyon] CHU Pitié-Salpêtrière [AP-HP] Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Jean Perrin [Clermont-Ferrand] Imagerie Moléculaire et Stratégies Théranostiques Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Imagerie Moléculaire et Stratégies Théranostiques Centre de Références Cancers Rares Institut national du cancer Hôpital Européen Georges Pompidou [APHP] Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Hôpital universitaire Robert Debré [Reims] Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand]
• Publié dans American Journal of Human Genetics le 29/10/2020

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Fichiers liés : S0002929721003396.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Nevzat TemurokFanny LeonElena PinchonMartine ClotVincent FoulongneJean-François CantaloubePhilippe Van De PerreChantal Fournier-WirthJean-Pierre MolesAurélien Daynès
• Organismes : HORIBA Medical Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections HORIBA Medical Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Régional Universitaire [Montpellier] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Régional Universitaire [Montpellier] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections HORIBA Medical
• Publié dans Talanta le 01/11/2020

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Résumé : Recent virus outbreaks have revealed a critical need for large scale serological assays. However, many available tests either require a cumbersome, costly apparatus or lack the availability of full automation. In order to address these limitations, we describe a homogeneous assay for antibody detection via measurement of superparamagnetic particles agglutination. Application of a magnetic field permits to overcome the limitations governed by Brownian translational diffusion in conventional assays and results in an important acceleration of the aggregation process as well as an improvement of the limit of detection. Furthermore, the use of protein-concentrated fluid such as 5 times-diluted human plasma does not impair the performances of the method. Screening of human plasma samples shows a strict discrimination between seropositive and seronegative samples in an assay duration as short as 14 s. The sensitivity of this method, combined with its quickness and simplicity, makes it a promising diagnostic tool.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Xiangzhuo LiuWigneron J.-P.Sassan S SaatchiFrédéric FrappartPhilippe CiaisNicolas BaghdadiMehrez ZribiThomas JagdhuberXiaojun LiMengjia WangXiaojing BaiChristophe Moisy
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Chongqing University [Chongqing] Interactions Sol Plante Atmosphère Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Territoires, Environnement, Télédétection et Information Spatiale Centre d'études spatiales de la biosphère German Aerospace Center Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Beijing Normal University Nanjing University Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Vegetation optical depth (VOD), as a microwave-based vegetation index for vegetation water and biomass content, is increasingly used to study the impact of global climate and environmental changes on vegetation. Currently, VOD is mainly retrieved from passive microwave data and few studies focused on VOD retrievals from active microwave data. The Advanced SCATterometer (ASCAT) provides long-term C-band backscatter data at Vertical-Vertical (VV) polarization. In this study, a new ASCAT INRAE Bordeaux (IB) VOD (hereafter, IB VOD), was developed based on the Water Cloud Model (WCM) coupled with the Ulaby linear model for soil backscattering. The main features of IB VOD are that (i) the ERA5-Land soil moisture (SM) dataset was used as an auxiliary SM dataset in the retrievals, (ii) pixel-based soil model parameters were mapped using Random Forest (RF), and (iii) the vegetation model parameter was calibrated for each day. The IB VOD product was retrieved over Africa during 2015–2019, and its performances were evaluated in space and time by comparing with aboveground biomass (AGB), lidar tree height (TH), normalized difference vegetation index (NDVI), enhanced vegetation index (EVI) and leaf area index (LAI). Results were inter-compared with three other VOD products at the same frequency. In terms of spatial correlation with AGB (R = 0.92) and TH (R = 0.89), IB VOD outperforms the other VOD products, suggesting IB VOD has a strong ability to capture spatial patterns of AGB and TH. By comparing all VOD products against NDVI, EVI and LAI, we found that the highest temporal correlation with NDVI (EVI, LAI) was obtained with IB VOD over 29.94% (36.65%, 30.19%) of the study region. Considering all three vegetations indices, highest temporal correlation values with IB VOD could be particularly noted for deciduous broadleaf forests, woody savannas and savannas.

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Fichiers liés : S0034425721003072.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Gerhard HindricksTatjana PotparaNikolaos DagresElena ArbeloJeroen BaxCarina Blomström-LundqvistGiuseppe BorianiManuel CastellaGheorghe-Andrei DanPolychronis DilaverisLaurent FauchierGerasimos FilippatosJonathan KalmanMark La MeirDeirdre LaneJean-Pierre LebeauMaddalena LettinoDavid FitzmauriceFausto PintoG Neil ThomasMarco ValgimigliIsabelle van GelderBart van PutteCaroline WatkinsJohannes BrachmannMichael KühneVictor AboyansAnders AhlssonPawel BalsamJohann BauersachsStefano BenussiAxel BrandesFrieder Braunschweiga John CammDavide CapodannoBarbara CasadeiDavid ConenHarry CrijnsVictoria DelgadoDobromir DobrevHeinz DrexelLars EckardtDonna FitzsimonsThierry FolliguetChris GaleBulent GorenekKarl Georg HaeuslerHein HeidbuchelBernard IungHugo KatusDipak KotechaUlf LandmesserChristophe LeclercqBasil LewisJulia MascherbauerJose Luis MerinoBéla MerkelyLluís MontChristian MuellerKlaudia NagyJonas OldgrenNikola PavlovićRoberto PedrettiSteffen PetersenJonathan PicciniBogdan PopescuHelmut PürerfellnerDimitrios RichterMarco RoffiAndrea RubboliDaniel ScherrRenate SchnabelIain SimpsonEvgeny ShlyakhtoMoritz SinnerJan SteffelMiguel Sousa-UvaPiotr SuwalskiMartin SvetlosakRhian TouyzG Neil ThomasTahar DelassiHamayak SisakianAlexandr ChasnoitsMichel De PauwElnur SmajićTchavdar ShalganovPanayiotis AvraamidesJosef KautznerChristian GerdesAhmad Abd AlazizPriit KampusPekka RaatikainenSerge BovedaGiorgi PapiashviliVassilios VassilikosZoltán CsanádiDavid ArnarJoseph GalvinAlon BarsheshetPasquale CaldarolaAmina RakishevaIbadete BytyçiAlina KerimkulovaOskars KalejsMario NjeimAras PuodziukynasLaurent GrobenMark SammutAurel GrosuAneta BoskovicAbdelhamid MoustaghfirNatasja De GrootLidija PoposkaOle-Gunnar AnfinsenPrzemyslaw MitkowskiDiogo Magalhães CavacoCalin SilisteEvgeny MikhaylovLuca BertelliDejan KojicRobert HatalaZlatko FrasFernando ArribasTord JuhlinChristian SticherlingLeila AbidIlyas AtarOleg SychovMatthew BatesNodir ZakirovJean-Michel HalimiPhilippe GataultHélène LonguetChristelle BarbetAnnabelle GoumardJuliette GueguenNicolas GoinBenedicte SautenetJulien HerbertArnaud Bisson
• Organismes : Leipzig University / Universität Leipzig University of Belgrade [Belgrade] Leipzig University / Universität Leipzig Leiden University Medical Center [Leiden] Uppsala University Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia Spitalul Clinic Colentina = Colentina Hospital [Bucharest, Romania] University of Medicine and Pharmacy “Carol Davila” CHU Trousseau [Tours] Éducation Éthique Santé National and Kapodistrian University of Athens Université d'Athènes “Attikon” University Hospital The Royal Melbourne Hospital University of Liverpool Éducation Éthique Santé San Gerardo Hospital Company Monza University of Liverpool Aalborg University Universidade Nova de Lisboa = NOVA University Lisbon Faculdade de Medicina [Lisboa] Hospital de Santa Maria [Lisboa] CHU Trousseau [Tours] Service de néphrologie et immunologie clinique [CHRU Tours] CHU Trousseau [Tours] CHU Trousseau [Tours] CHU Trousseau [Tours] Centre de recherche en épidémiologie et santé des populations methodS in Patients-centered outcomes and HEalth ResEarch Service de néphrologie et immunologie clinique [CHRU Tours] CHU Trousseau [Tours] CHU Trousseau [Tours]
• Publié dans Kidney International Reports le 26/10/2020

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Helena DegrooteFederico PiñeroCharlotte CostentinAndrea NotarpaoloIlka F BoinKarim BoudjemaCinzia BaccaroAline Lopes ChagasPhilippe BachellierGiuseppe Maria EttorreJaime PoniachikFabrice MuscariFabrio Di BenedettoSergio Hoyos DuqueÉphrem SalameUmberto CilloAdrián GadanoClaire VanlemmensStefano FagiuoliFernando RubinsteinPatrizia BurraDaniel CherquiMarcelo SilvaHans van VlierbergheChristophe DuvouxFilomena ContiOlivier ScattonPierre-Henri BernardClaire FrancozFrançois DurandSebastien DharancyMarie-Lorraine WoehlAlexis LaurentSylvie RadenneJérôme DumortierArmand AbergelLouise BarbierPauline Houssel-DebryGeorges-Philippe PageauxLaurence ChicheVictor DeledinghenJean HardwigsenJ. GugenheimM. AltieriMarie-Noëlle HilleretThomas DecaensAline ChagasPaulo S CostaElaine Cristina de AtaideEmilio QuiñonesSebastian MarcianoMargarita AndersAdriana VarónAlina ZeregaAlejandro SozaMartín Padilla-MachacaDiego ArufeJosemaría MenéndezRodrigo ZapataMario VilatobaLinda MuñozRicardo Chong-MenéndezMartín MaraschioLuis G PodestáMartin FaudaA. Gonzalez-CampañaLucas MccormackJuan MatteraIlka Sf Fatima BoinJose Huygens Parente GarcíaFlair CarrilhoGiulia MaginiLucia MiglioresiMartina GambatoFabrizio DibenedettoCecilia d'AmbrosioAlessandro VitaleMichele ColledanDomenico PinelliPaolo MagistriGiovanni VennarecciMarco ColasantiValerio GiannelliAdriano PellicelliCizia BaccaroCallebout EduardIesari SamueleDekervel JeroenJonas SchreiberJacques PirenneChris VerslypeDirk YsebaertPeter MichielsenValerio LucidiChristophe MorenoOlivier DetryJean DelwaideRoberto TroisiJan-Paul Lerut
• Organismes : Ghent University Hospital Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Centre Hospitalier Universitaire [CHU Grenoble] Arcispedale S Maria Nuova Universidade Estadual de Campinas = University of Campinas Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Toulouse Universidad de Antioquia = University of Antioquia [Medellín, Colombia] CHU Trousseau [Tours] Centre Hospitalier Régional Universitaire de Besançon Hospital Papa Giovanni XXIII Ghent University Hospital Service d'hépato-gastro-entérologie [APHP Henri Mondor] Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
• Publié dans JHEP Reports Innovation in Hepatology le 07/09/2020

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Résumé : BACKGROUND and AIMS: Good outcomes after liver transplantation (LT) have been reported after successfully downstaging to Milan criteria in more advanced hepatocellular carcinoma (HCC). We aimed to compare post-LT outcomes in patients receiving locoregional therapies (LRT) before LT according to Milan criteria and University of California San Francisco downstaging (UCSF-DS) protocol and ’all-comers’. METHODS: This multicentre cohort study included patients who received any LRT before LT from Europe and Latin America (2000-2018). We excluded patients with alpha-foetoprotein (AFP) above 1,000 ng/ml. Competing risk regression analysis for HCC recurrence was conducted, estimating subdistribution hazard ratios (SHRs) and corresponding 95% CIs. RESULTS: From 2,441 LT patients, 70.1% received LRT before LT (n = 1,711). Of these, 80.6% were within Milan, 12.0% within UCSF-DS, and 7.4% all-comers. Successful downstaging was achieved in 45.2% (CI 34.8-55.8) and 38.2% (CI 25.4-52.3) of the UCSF-DS group and all-comers, respectively. The risk of recurrence was higher for all-comers (SHR 6.01 [p <0.0001]) and not significantly higher for the UCSF-DS group (SHR 1.60 [p = 0.32]), compared with patients remaining within Milan. The all-comers presented more frequent features of aggressive HCC and higher tumour burden at explant. Among the UCSF-DS group, an AFP value of ≤20 ng/ml at listing was associated with lower recurrence (SHR 2.01 [p = 0.006]) and better survival. However, recurrence was still significantly high irrespective of AFP ≤20 ng/ml in all-comers. CONCLUSIONS: Patients within the UCSF-DS protocol at listing have similar post-transplant outcomes compared with those within Milan when successfully downstaged. Meanwhile, all-comers have a higher recurrence and inferior survival irrespective of response to LRT. Additionally, in the UCSF-DS group, an ALP of ≤20 ng/ml might be a novel tool to optimise selection of candidates for LT. CLINICAL TRIAL NUMBER: This study was registered as part of an open public registry (NCT03775863). LAY SUMMARY: Patients with more extended HCC (within the UCSF-DS protocol) successfully downstaged to the conventional Milan criteria do not have a higher recurrence rate after LT compared with the group remaining in the Milan criteria from listing to transplantation. Moreover, in the UCSF-DS patient group, an ALP value equal to or below 20 ng/ml at listing might be a novel tool to further optimise selection of candidates for LT.

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Fichiers liés : Degroote-2021-International study on the outcome of locoregional therapy.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2021
• Auteurs : Pierre-Jean LartaudDavid HalléArnaud SchleefRiham DessoukyAnna Sesilia VlachomitrouPhilippe DouekJean-Michel RouetOlivier NempontL. Boussel
• Organismes : Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis
• Publié dans International Journal of Computer Assisted Radiology and Surgery le 30/10/2020

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