Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 13/08/2021
• Auteurs : François MuratetElisa TeyssouAude ChiotSéverine BoilléeChristian S. LobsigerDelphine BohlBeata GyorgyJustine GueganYannick MarieMaria-Del-Mar AmadorFrancois SalachasVincent MeiningerEmilien BernardJean-Christophe AntoineJean- Philippe CamdessanchéWilliam CamuCécile CazeneuveAnne-Laure Fauret-AmsellemEric LeguernKevin MouzatClaire GuissartSerge LumbrosoPhilippe CorciaPatrick Vourc’hAude-Marie GrapperonShahram AttarianAnnie VerschuerenDanielle SeilheanStéphanie Millecamps
• Organismes : Institut du Cerveau = Paris Brain Institute Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Hôpital privé des Peupliers (Paris) Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre Sclérose Latérale Amyotrophique et maladies du motoneurone [CHU Saint-Etienne] Centre Sclérose Latérale Amyotrophique et maladies du motoneurone [CHU Saint-Etienne] Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Centre Hospitalier Universitaire de Nîmes Institut des Neurosciences de Montpellier Institut des Neurosciences de Montpellier Centre Hospitalier Universitaire de Nîmes Institut des Neurosciences de Montpellier Centre Hospitalier Universitaire de Nîmes Centre de compétence de la Sclérose Latérale Amyotrophique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

---

Résumé : Objective Mutations in superoxide dismutase 1 gene ( SOD1) , encoding copper/zinc superoxide dismutase protein, are the second most frequent high penetrant genetic cause for amyotrophic lateral sclerosis (ALS) motor neuron disease in populations of European descent. More than 200 missense variants are reported along the SOD1 protein. To limit the production of these aberrant and deleterious SOD1 species, antisense oligonucleotide approaches have recently emerged and showed promising effects in clinical trials. To offer the possibility to any patient with SOD1-ALS to benefit of such a gene therapy, it is necessary to ascertain whether any variant of unknown significance (VUS), detected for example in SOD1 non-coding sequences, is pathogenic. Methods We analysed SOD1 mutation distribution after SOD1 sequencing in a large cohort of 470 French familial ALS (fALS) index cases. Results We identified a total of 27 SOD1 variants in 38 families including two SOD1 variants located in nearsplice or intronic regions of the gene. The pathogenicity of the c.358–10T>G nearsplice SOD1 variant was corroborated based on its high frequency (as the second most frequent SOD1 variant) in French fALS, the segregation analysis confirmed in eight affected members of a large pedigree, the typical SOD1-related phenotype observed (with lower limb onset and prominent lower motor neuron involvement), and findings on postmortem tissues showing SOD1 misaccumulation. Conclusions Our results highlighted nearsplice/intronic mutations in SOD1 are responsible for a significant portion of French fALS and suggested the systematic analysis of the SOD1 mRNA sequence could become the method of choice for SOD1 screening, not to miss these specific cases.

---

Fichiers liés : Muratet et al. - 2021 - Impact of a frequent nearsplice SOD1 variant in am.pdf

---

Source

---

• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 09/08/2021
• Auteurs : Sarah BaillyVanessa MachaultSamuel BeneteauPhilippe PalanyRomain GirodJean-Pierre LacauxPhilippe QuenelClaude Flamand
• Organismes : Unité d'Epidémiologie [Cayenne, Guyane française] Laboratoire d'aérologie Unité d'Epidémiologie [Cayenne, Guyane française] Direction Inter-Régionale des Antilles-Guyane Entomologie médicale [Cayenne, Guyane française] Institut Pasteur de Madagascar Laboratoire d'aérologie Institut de recherche en santé, environnement et travail Entomologie médicale [Cayenne, Guyane française] Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases

---

Résumé : Although the development of vaccines for the prevention of arboviral diseases has been a priority in recent years, prevention strategies continue to depend on vector control. Risk maps at scales appropriate for these strategies can provide valuable information to assess entomological risk levels and guide actions. We used a spatio-temporal modeling approach to predict, at the local scale, the risk of homes potentially harboring Aedes aegypti larvae. The model used integrated larvae risk data collected in the field from September 2011 to February 2013, environmental data obtained from very high spatial resolution Pleiades imagery, and daily meteorological data, collected in the city of Matoury in French Guiana. Various environmental and meteorological conditions were identified as risk or protective factors for the presence of immature stages of Aedes aegypti in homes on a given date and used to produce dynamic maps with high spatial and temporal resolution. Aedes vector risk was modeled between 50 and 200 m, around houses, on a time scale of 3 to 5 days. The resulting model was extrapolated to other municipalities with the same characteristics of urbanization during the 2019-2020 dengue epidemic in French Guiana. This work represents a major opportunity to monitor the evolution of vector risk and constitutes information that could be particularly useful for public health authorities in charge of vector control.

---

Fichiers liés : 2021.08.02.21261373v1.full.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 09/08/2021
• Auteurs : Minh Thuong KhongValerie Berl BauderLauriane KuhnPhilippe HammannJean-Pierre Lepoittevin
• Organismes : Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg
• Publié dans Chemical Research in Toxicology le 29/10/2020

---

Résumé : Chemical skin and respiratory allergies are becoming a major health problem. To date our knowledge on the process of protein haptenation is still limited and mainly derived from studies performed in solution using model nucleophiles. In order to better understand chemical interactions between chemical allergens and the skin, we have investigated the reactivity of phthalic anhydride 1 (PA), a chemical respiratory sensitizer, towards reconstructed human epidermis (RHE). This study was performed using a new approach combining HRMAS NMR to investigate the in situ chemical reactivity and LC-MS/MS to identify modified epidermal proteins. In RHE, the reaction of PA appeared to be quite fast and the major product formed was phthalic acid. Two amide type adducts on lysine residues were observed and after 8h of incubation, we also observed the formation of an imide type cyclized adducts with lysine. In parallel, RHE samples topically exposed to phthalic anhydride (13C)-1 were analyzed using the shotgun proteomics method. Thus, 948 different proteins were extracted and identified, 135 of which being modified by PA i.e. 14.2% of the extracted proteome. A total of 211 amino acids were modified by PA and validated by fragmentation spectra. We thus identified 154 modified lysines ,22 modified histidines , 30 modified tyrosines and 5 modified arginines. The rate of modified residues, as a proportion of the total number of modifiable nucleophilic residues in RHE, was rather low (1%). At the protein level, modified proteins were mainly type I and type II keratins and other proteins which are abundant in the epidermis such as protein S100A, Caspase 14, annexin A2, serpin B3, Fatty-acid binding protein 5, histone H2, H3, H4 etc. However, the most modified protein, mainly on histidine residues, was filaggrin, a protein that is of low abundance (0.0266 mol%) and rich in histidine.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 08/08/2021
• Auteurs : Albert RilliardPhilippe Boula de MareüilFrédéric VernierJean-Pierre Lai
• Organismes : Traitement du Langage Parlé - LISN Laboratoire Interdisciplinaire des Sciences du Numérique Traitement du Langage Parlé - LISN Laboratoire Interdisciplinaire des Sciences du Numérique Analysis and Visualization Laboratoire Interdisciplinaire des Sciences du Numérique GIPSA-Services GIPSA - SYstèmes Linguistiques, Dialectologie et Oralité

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 06/08/2021
• Auteurs : Marta Andrea SiragusaThomas RufinRobert CourtoisCatherine BelzungFrédéric AnderssonBruno BrizardPaul-Armand DujardinJean-Philippe CottierFrédéric PatatJean-Pierre RemenierasValérie GissotWissam El-HageVincent CamusThomas Desmidt
• Organismes : Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Qualité de vie et Santé psychologique Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Centre d’Investigation Clinique [Tours] CIC 1415 Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Centre d’Investigation Clinique [Tours] CIC 1415 Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours
• Publié dans Brain imaging and behavior (Brain Imaging Behav) le 28/10/2020

---

Résumé : Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (n = 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.

---

Fichiers liés : Left amygdala volume and brain tissue pulsatility are associated with neuroticism an MRI and ultrasound study.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 06/08/2021
• Auteurs : Frédéric JacobThomas H.G. VidalAudrey LesaignouxAlbert OliosoMarie WeissFrançoise NerryStéphane JacquemoudPhilippe GametKarine CaillaultLuc LabarreAndrew FrenchThomas SchmuggeXavier BriottetJean-Pierre Lagouarde
• Organismes : Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Analytic and Computational Research, Inc. - Earth Sciences Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Institut de Physique du Globe de Paris Centre d'études spatiales de la biosphère DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] USDA Agricultural Research Service [Maricopa, AZ] Northwest Missouri State University DOTA, ONERA, Université de Toulouse [Toulouse] Interactions Sol Plante Atmosphère
• Publié dans IEEE Transactions on Geoscience and Remote Sensing le 31/10/2020

---

Résumé : In preparation of the micro-bolometer based MIcro Satellite for Thermal Infrared GRound surface Imaging (MIST-IGRI) mission, we study the error budget of the Temperature-Emissivity Separation (TES) method using several spectral configurations that differ in channel numbers, locations, and widths. The error budget quantifies the contribution of (1) the TES underlying assumption about emissivity spectral contrast, (2) the errors on atmospheric corrections, and (3) the instrumental noise. When dealing with atmospheric corrections, we consider errors on atmospheric temperature, water vapor content, and concentrations of CO2 and O3. To that end, we design an end-to-end simulator of MISTIGRI measurements in order to simulate the radiative and biophysical quantities involved in the data processing. We conduct numerous simulations over a wide range of realistic setups that include cavity effect, i.e., radiance trapping within vegetation canopy. In the case of micro-bolometer based sensing, the current study highlights that atmospheric and instrumental noises have similar impacts on the TES retrievals, with resulting errors twice as large as those due to the TES intrinsic assumption about spectral contrast, where the latter contributes to the TES error budget within the [0.005-0.009] interval for emissivity, and within the [0.3 K-0.4 K] interval for LST. Also, we show that retrieval performances of surface temperature are very similar across all considered MISTIGRI spectral configurations, with RMSE variation within 0.2 K.

---

Fichiers liés : z50-oa-file2.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Amira BouzidiLabreche KarimMarine BaronMarianne VeyriJérôme Alexandre DenisMehdi TouatMarc SansonFrédéric DaviErell GuillermStéphanie JouannetFrédéric CharlotteFranck BielleSylvain ChoquetPierre-Yves BoëlleJacques CadranelVéronique LeblondBrigitte AutranJean-Marc LacorteJean-Philippe SpanoFlorence Coulet
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Biologie et thérapeutiques du cancer [CRSA] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Instabilité des microsatellites et cancers [CRSA] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Frontiers in Cell and Developmental Biology le 22/10/2020

---

Résumé : Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect genomic abnormalities by directly testing a blood sample. This method is particularly useful for immunosuppressed patients, who are at high risk of complications from tissue biopsy. The cfDNA tumor fraction (TF) varies greatly across cancer type and between patients. Thus, the detection of molecular alterations is highly dependent on the circulating TF. In our study, we aimed to calculate the TF and characterize the copy number aberration (CNA) profile of cfDNA from patients with rare malignancies occurring in immunosuppressed environments or immune-privileged sites. To accomplish this, we recruited 36 patients: 19 patients with non-Hodgkin lymphoma (NHL) who were either human immunodeficiency virus (HIV)-positive or organ transplant recipients, 5 HIV-positive lung cancer patients, and 12 patients with glioma. cfDNA was extracted from the patients’ plasma and sequenced using low-coverage whole genome sequencing (LC-WGS). The cfDNA TF was then calculated using the ichorCNA bioinformatic algorithm, based on the CNA profile. In parallel, we performed whole exome sequencing of patient tumor tissue and cfDNA samples with detectable TFs. We detected a cfDNA TF in 29% of immune-suppressed patients (one patient with lung cancer and six with systemic NHL), with a TF range from 8 to 70%. In these patients, the events detected in the CNA profile of cfDNA are well-known events associated with NHL and lung cancer. Moreover, cfDNA CNA profile correlated with the CNA profile of matched tumor tissue. No tumor-derived cfDNA was detected in the glioma patients. Our study shows that tumor genetic content is detectable in cfDNA from immunosuppressed patients with advanced NHL or lung cancer. LC-WGS is a time- and cost-effective method that can help select an appropriate strategy for performing extensive molecular analysis of cfDNA. This technique also enables characterization of CNAs in cfDNA when sufficient tumor content is available. Hence, this approach can be used to collect useful molecular information that is relevant to patient care.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Quentin LisanThomas T van SlotenPierre BoutouyrieStéphane LaurentNicolas DanchinFrédérique ThomasCatherine GuiboutMarie‐cécile PerierPieter DagnelieRonald HenryMiranda SchramRaphaël HeinzerPedro Manuel Marques-VidalCarla van der KallenHarry CrijnsMarleen van GreevenbroekKoen ReesinkSebastian KöhlerManuel SastryXavier JouvenCoen StehouwerJean‐philippe Empana
• Organismes : Paris-Centre de Recherche Cardiovasculaire
• Publié dans Journal of the American Heart Association le 28/10/2020

---

Résumé : Background The mechanisms underlying the association between obstructive sleep apnea (OSA) and cardiovascular disease may include accelerated vascular aging. The aim was to compare the magnitude of vascular aging in patients with high versus low risk of OSA. Methods and Results In 2 community‐based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study, high risk of OSA was determined with the Berlin questionnaire (a screening questionnaire for OSA). We assessed carotid artery properties (carotid intima‐media thickness, Young’s elastic modulus, carotid‐femoral pulse wave velocity, carotid pulse wave velocity, carotid diameter using high precision ultrasound echography), and carotid‐femoral pulse wave velocity (in the Maastricht Study only). Regression coefficients were estimated on pooled data using multivariate linear regression. A total of 8615 participants without prior cardiovascular disease were included (6840 from PPS3, 62% men, mean age 59.5±6.2 years, and 1775 from the Maastricht Study, 51% men, 58.9±8.1 years). Overall, high risk of OSA prevalence was 16.8% (n=1150) in PPS3 and 23.8% (n=423) in the Maastricht Study. A high risk of OSA was associated with greater carotid intima‐media thickness (β=0.21; 0.17–0.26), Young’s elastic modulus (β=0.21; 0.17–0.25), carotid‐femoral pulse wave velocity (β=0.24; 0.14–0.34), carotid pulse wave velocity (β=0.31; 0.26–0.35), and carotid diameter (β=0.43; 0.38–0.48), after adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site. Consistent associations were observed after additional adjustments for mean blood pressure, body mass index, or antihypertensive medications. Conclusions These data lend support for accelerated vascular aging in individuals with high risk of OSA. This may, at least in part, underlie the association between OSA and cardiovascular disease.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Gregory SchwartzMichael SzarekVera BittnerRafael DiazShaun GoodmanJ Wouter JukemaUlf LandmesserPatricio López-JaramilloGaren ManvelianRobert PordyMichel ScemamaPeter SinnaeveHarvey WhitePhilippe Gabriel StegJ. Wouter JukemaDeepak BhattRobert HarringtonAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefWilliam SasielaJean-François TambyPhilip AylwardHeinz DrexelMirza DilicRenato LopesNina GotchevaJuan-Carlos PrietoHuo YongIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo Carlos Montenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisDavid MaronJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicÉtienne PuymiratWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio JureJulio O.E. BonoAdrian HrabarJulio VallejosRodolfo Ahuad GuerreroFederico NovoaCristian PatocchiCesar ZaidmanMaria GiulianoRicardo DranMarisa VicoGabriela CarneroPablo GuzmanJuan Medrano AllendeDaniela Garcia BrascaMiguel Bustamante LabartaSebastian NaniEduardo D.S. BlumbergHugo ColomboAlberto LibermanVictorino FuentealbaHector LuciardiGabriel WaismanMario BerliRuben Garcia DuranHoracio CestariHugo LuquezJorge GiordanoSilvia SaavedraGerardo ZapataOsvaldo CostamagnaSusana LloisJonathon WaitesNicholas CollinsAllan SowardChris L.S. HiiJames ShawMargaret ArstallJohn HorowitzDaniel NinioJames RogersDavid ColquhounRomulo Oqueli FloresPhilip Roberts-ThomsonOwen RaffelSam LehmanConstantine AroneySteven G.M. CoverdalePaul GarrahyGregory StarmerMark SaderPatrick CarrollRonald DickRobert ZweikerUta HoppeKurt HuberRudolf BergerGeorg Delle-KarthBernhard FreyDirk FaesKurt HermansBruno PirenneAttilio LeoneEtienne HofferMathias C.M. VrolixLuc de WolfBart WollaertMarc CastadotKarl DujardinChristophe BeauloyeGeert VervoortHarry StriekwoldCarl ConvensJohn RoosenEmanuele BarbatoMarc ClaeysFrank CoolsIbrahim TerzicFahir BarakovicZlatko MidzicBelma PojskicEmir FazlibegovicAzra Durak-NalbanticMehmed KulićDusko VulicAdis MuslibegovicBoris GoronjaGilmar ReisLuciano SousaJose NicolauFlavio GiorgetoRicardo SilvaLilia Nigro MaiaRafael RechPaulo R.F. RossiMaria José A.G. CerqueiraNorberto DudaRenato KalilAdrian KormannJosé Antonio M. AbrantesPedro Pimentel FilhoAna Priscila SoggiaMayler O.N. de SantosFernando NeuenschwanderLuiz BodaneseYorghos MichalarosFreddy EliaschewitzMaria VidottiPaulo LeaesRoberto BotelhoSergio KaiserEuler Roberto F. Fernandes ManentiDalton PrecomaJose Moura JorgePedro SilvaJose SilveiraWladmir SaporitoJose Marin NetoGilson FeitosaLuiz Eduardo F. RittJuliana de SouzaFernando CostaWeimar K.S.B. SouzaHelder J.L. ReisLeandro MachadoJosé Carlos Aidar AyoubGeorgi TodorovFedya NikolovElena VelchevaMaria TzekovaHaralambi BenovStanislav PetranovHaralin TumbevNina Shehova-YankovaDimitar MarkovDimitar RaevMihail MollovKostadin KichukovKatya Ilieva-PandevaRaya IvanovaMaryana GospodinovValentina MinchevaPetar LazovBojidar DimovManohara SenaratneJames StoneJan KornderStephen PearceDanielle DionDaniel SavardYves PesantAmritanshu PandeySimon RobinsonGilbert GosselinSaul VizelGordon HoagRonald BourgeoisAnne MorissetEric SabbahBruce SussexSimon KouzPaul MacdonaldAriel DiazNicolas MichaudDavid FellRaymond LeungTycho VuurmansChristopher LaiFrank NigroRichard DaviesGustavo NogaredaRam VijayaraghavanJohn DucasSerge LepageShamir MehtaJames ChaRobert DupuisPeter FongSohrab LutchmedialJosep Rodés-CabauHussein FadlallahDavid ClevelandThao HuynhIqbal BataAdnan HameedCristian PincettiSergio PotthoffJuan PrietoMonica AcevedoArnoldo AguirreMargarita VejarMario YañezGuillermo AranedaMauricio FernandezLuis PerezPaola VarletaFernando FlorenzanoLaura HuidobroCarlos RaffoClaudia OlivaresLeonardo NahuelpanHumberto MontecinosJiyan ChenYugang DongWeijian HuangJianzhong WangShi'An HuangZhuhua YaoXiang LiLan CuiWenhua LinYuemin SunJingfeng WangJianping LiXuelian ZhangHong ZhuDandan ChenLan HuangShaohong DongGuohai SuBiao XuXi SuXiaoshu ChengJinxiu LinWenxia ZongHuanming LiYi FengDingli XuXinchun YangYuannan KeXuefeng LinZheng ZhangZeqi ZhengZhurong LuoYundai ChenChunhua DingYi ZhongYang ZhengXiaodong LiDaoquan PengShuiping ZhaoWeiguo LiXuebo LiuMeng WeiShaowen LiuYihua YuBaiming QuWeihong JiangYujie ZhouXingsheng ZhaoZuyi YuanYing GuoXiping XuXubo ShiJunbo GeGuosheng FuFeng BaiWeiyi FangXiling ShouXiangjun YangJian'An WangMeixiang XiangYingxian SunQinghua LuRuiyan ZhangJianhua ZhuYizhou XuZhongcai FanTianchang LiChun WuNicolas JaramilloGregorio Sanchez VallejoDiana Luna BotiaRodrigo Botero LopezDora Molina de SalazarAlberto Cadena BonfantiCarlos Cotes ArocaJuan Diego HigueraMarco BlanquicettSandra Barrera SilvaHenry Garcia LozadaJulian Coronel ArroyoJose Accini MendozaRicardo Fernandez RuizAlvaro Quintero OssaFernando Manzur JatinAristides Sotomayor HerazoJeffrey Castellanos ParadaRafael Suarez ArambulaMiguel Urina TrianaAngela Fernandez TrujilloMaja StrozziSiniša CarMelita JerićDavor MiličićMartina Lovrić BenčićHrvoje PintarićĐeiti PrvulovićJozica ŠikićViktor PeršićDean MiletaKresimir ŠtambukZdravko BabićVjekoslav TomulicJosip LukendaStanka Mejic-KrstulovicBoris StarcevicJindrich SpinarDavid HorakZdenek VelickaJosef StasekDavid AlanVilma MachovaAles LinhartVojtech NovotnyVladimir KaucakRichard RokytaRobert NaplavaZdenek CoufalVera AdamkovaIvo PodperaJiri ZizkaZuzana MotovskaIvana MarusincovaPremysl SvabPetr HeincJiri KucharPetr PovolnyJiri MatuskaSteen PoulsenBent RaungaardPeter ClemmensenLia BangOle MayMorten BøttcherJens HoveLars FrostGunnar GislasonJohn LarsenPeter Betton JohansenFlemming HaldPeter JohansenJørgen JeppesenTonny NielsenKjeld KristensenPiotr Maria WalichiewiczJens LomholdtIb KlausenPeter Kaiser NielsenFlemming DavidsenLars VidebaekMai SootsVeiko VahulaAnu HedmanÜllar SoopõldKaja MärtsinTiina JurgensonArved KristjanHeikki HuikuriJuhani Airaksinen Pierre CosteEmile FerrariOlivier MorelGilles MontalescotJacques MachecourtGilles Barone-RochetteJacques MansouratiYves CottinFlorence LeclercqAbdelkader BelhassaneNicolas DelarcheFranck BoccaraFranck PaganelliJérôme ClercFrançois SchieleVictor AboyansVincent ProbstJacques BerlandThierry LefèvreBernard CitronIrakli KhintibidzeTamaz ShaburishviliZurab PagavaRamaz GhlontiZaza LominadzeGeorge KhabeishviliRayyan HemetsbergerKemala EdwardUrsula Rauch-KröhnertMatthias StratmannKarl-Friedrich AppelEkkehard SchmidtHeyder OmranChristoph StellbrinkThomas DorselEmmanouil LianopoulosHans Friedrich VöhringerRoger MarxAndreas ZirlikDetlev SchellenbergThomas HeitzerUlrich LaufsChristian WernerStephan GielenSebastian NudingBernhard WinkelmannSteffen BehrensKarsten SydowMahir KarakasGregor SimonisThomas MuenzelNikos WernerStefan LeggewieDirk BöckerRüdiger Braun-DullaeusNicole ToursarkissianMichael JeserichMatthias WeissbrodtTim SchaeufeleJoachim WeilHeinz VöllerJohannes WaltenbergerMohammed NatourSusanne SchmittDirk Müller-WielandStephan SteinerLothar HeidenreichElmar OffersUwe GremmlerHolger KillatWerner RiekerSotiris PatsilinakosAthanasios KartalisAthanassios ManolisDimitrios SionisGeargios ChachalisIoannis SkoumasVasilios AthyrosPanagiotis VardasFrangkiskos ParthenakisJohn LekakisApostolos HatzitoliosSergio Fausto OvandoJuan Arango BeneckeEdgar Rodriguez de LeonBryan P.Y. YanDavid C.W. SiuTibor TuriBela MerkelyImre UngiGeza LupkovicsLajos NagyAndrás KatonaIstván ÉdesGábor MüllerIván HorvathTibor KapinZsolt SzigetiJózsef FaluközyMukund KumblaManjinder SandhuSharath AnnamNaveen Reddy ProdduturReddy RegellaRajendra PremchandAjaykumar MahajanSudhir PawarAtul AbhyanakarPrafulla KerkarRavishankar GovindaAbraham OommanDhurjati SinhaSachin PatilDhiman KahaliJitendra SawhneyAbhijeet JoshiSanjeev ChaudharyPankaj HarkutSantanu GuhaSanjay PorwalSrimannarayana JujjuruRamesh PothineniMinguel MonteiroAziz KhanShamanna IyengarJasprakash Singh GrewalManoj ChopdaMahesh FulwaniAparna PatangePatil SachinVijay ChopraNaresh GoyalRituparna ShindeGajendra ManaksheNitin PatkiSumeet SethiVengatesh MunusamySunil Karnaand Sunil ThanviSrilakshmi AdhyapakChandrakant PatilUlhas PandurangiRishabh MathurJugal GuptaSuhas KalashettiAjit BhagwatBagirath RaghuramanShiv Kumar YerraPrasant BhansaliRohidas BorsePatil RahulSrihari DasVinay KumarJabir AbdullakuttyShireesh SaathePriya PalimkarJabir AbdullkuttyShireesh SatheShaul AtarMichael ShechterMorris MosseriYaron ArbelChorin EhudHavakuk OferChaim LotanUri RosenscheinAmos KatzYaakov HenkinAdi FrancisMarc KlutsteinEugenia NikolskyRobert ZukermannYoav TurgemanMajdi HalabiAlon MarmorRan KornowskiMichael JonasOffer AmirYonathan HasinYoseph RozenmanShmuel FuchsVered ZviOsamah HusseinDov GavishZvi VeredYoseph CaracoMazen EliasNaveh TovEfrat WolfovitzMichael LishnerNizar EliasGiancarlo PiovaccariAnnamaria de PellegrinRaffaella GarbelottoGabriele GuardigliValgimigli MarcoGiovanni LicciardelloCarla AuguadroFilippo ScaliseClaudio CucciaAlessandro SalvioniGiuseppe MusumeciMichelle SenniPaolo CalabròSalvatore NovoPompilio FaggianoMarco MetraNicoletta de CesareSergio BertiClaudio CavalliniEnrico PuccioniMarcello GalvaniMaurizio TespiliPiermarco PiattiMichela PalvariniGiuseppe de LucaRoberto VioliniAlessandro de LeoZoran OlivariPasquale Perrone FilardiMaurizio FerratiniVittorio RaccaKazuoki DaiYuji ShimataniHaruo KamiyaKenji AndoYoshihiro TakedaYoshihiro MorinoYoshiki HataKazuo KimuraKoichi KishiIchiro MichishitaHiroki UeharaToshinori HigashikataAtsushi HirayamaKeiji HirookaYasuji DoiSatoru SakagamiShuichi TaguchiAkihiro KoikeHiroyuki FujinagaShinji KobaKen KozumaTomohiro KawasakiYujiro OnoMasatoshi ShimizuYousuke KatsudaAtsuyuki WadaToshiro ShinkeJunya AkoKenshi FujiiToshiyuki TakahashiTomohiro SakamotoKoichi NakaoYutaka FurukawaHiroshi SuginoRitsu TamuraToshiaki ManoMasaaki UematsuNoriaki UtsuKashima ItoTakuya HaraguchiKatsuhiko SatoYasunori UedaAkira NishibeKazuteru FujimotoMotomaru MasutaniJung Han YoonHack-Lyoung KimHun Sik ParkIn-Ho ChaeMoo Hyun KimMyung Ho JeongSeungwoon RhaChongjin KimHae Young KimTaekjong HongSeung-Jea TahkYoungkwon KimArija BusmaneNatalija PontagaAldis StrelnieksIveta MintaleIveta SimeZaneta PetrulionieneRoma KavaliauskieneRuta JurgaitieneGintare SakalyteRimvydas SlapikasSigute NorkieneNerijus MisonisAleksandras KibarskisRaimondas KubiliusStojko BojovskiNensi LozanceAleksandar KjovkaroskiSnezana DoncovskaTiong Kiam OngSazzli KasimOteh MaskonBalachandran KandasamyHoung LiewWan Mohd Izani Wan MohamedArmando García CastilloJorge Carrillo CalvilloPedro Fajardo CamposJuan Carlos Núñez FragosoEdmundo Alfredo Bayram LlamasMarco Antonio Alcocer GambaJaime Carranza MadrigalLuis Gerardo González SalasEnrique López RosasBelinda González DíazEduardo Salcido VázquezAlfredo Nacoud AckarGuillermo Antonio Llamas EsperónCarlos Rodolfo Martínez SánchezMaría Guerrero de LeonRodrigo Suarez OteroGuillermo Fanghänel SalmónJesús Antonio Pérez RíosJosé Angel Garza RuízRobert BreedveldMargriet Feenema-AardemaAlida Borger-van Der BurgPieter A.M. HoogslagHarry SuryapranataAntonius OomenPaulus van HaelstMargriet Feenema-ArademaJacobijne WiersmaDirk BasartRuud M.A. van Der WalPeter ZwartPascalle MonraatsHenricus van KesterenIoannis KaralisJohan JukemaGerardus J.E. VerdelBart R.G. BruerenRoland Pth TroquayEric ViergeverNadea Y.Y. Al-WindyGerard BartelsJan CornelWalter R.M. HermansJohannes P.R. HerrmanRobert BosReginald G.E.J. GroutarsCoenraad van Der ZwaanRefik KaplanRaymond LionaronsEelko RonnerBjorn GroenemeijerPatrick N.A. BronzwaerAnho A.H. LiemBernard J.W.M. RensingMarcel J.J.A. BokernRemco NijmeijerFerry M.R.J. HersbachFrank WillemsAntonius T.M. GosselinkSaman RasoulJohn ElliottGerard WilkinsRaewyn FisherMichael SchubnellHamish HartRalph StewartScott HardingIan TernouthNicholas FisherSamuel WilsonDenise AitkenRussell AnscombeLaura DavidsonTadeusz TomalaOttar NygårdJon Arne SparbyKjell AndersenLars GullestadJarle JortveitPeter MunkErlend Gyllensten SingsaasUlf HurtigJorge Calderon TiconaJulio Durand VelasquezSandra Negron MiguelEnrique Sanabria PerezJesus Carrion ChambillaCarlos Chavez AyalaReynaldo Castillo LeonRolando Vargas GonzalesJose Hernandez ZunigaLuis Camacho CosavalenteJorge Bravo MannucciJavier Heredia LandeoNassip Llerena NavarroYudy Roldan ConchaVíctor Rodriguez ChavezHenry Anchante HernandezCarlos Zea NunezWalter Mogrovejo RamosArthur FerrolinoRosa Allyn G. SyLouie TiradorGeneroso MatigaRaul Martin CochingAlisa BernanGregorio RogelioDante MoralesEdgar TanDennis Jose SulitAdrian WlodarczakKrystyna JaworskaGrzegorz SkoniecznyLidia PawlowiczPawel WojewodaBenita Busz-PapiezJanusz BednarskiAleksander GochPawel StanetaElzbieta DulakKrzysztof SaminskiWlodzimierz KrasowskiWanda SudnikAleksander ZurakowskiMarcin SkorskiRoman LysekBeata MiklaszewiczJacek KubicaJan Andrzej LipkoEdyta Kostarska-SrokoszMarek PiepiorkaAnna DrzewieckaRyszard SciborskiArkadiusz StasiewskiTomasz BlicharskiLeszek BystrykMichal SzpajerMarek KorolTomasz CzerskiEwa Mirek-BryniarskaJacek GniotAndrzej LubinskiJerzy GornyEdward FranekGrzegorz RaczakHanna SzwedPedro MonteiroJose Mesquita BastosHelder PereiraDinis MartinsFilipe SeixoCarlos MendonçaAna BotelhoFrancisca CaetanoBogdan MinescuOctavian IstratoaieDan TesloianuGabriel CristianSilviu DumitrescuCristian G.C. PodoleanuMircea C.A. ConstantinescuCristina BengusConstantin MilitaruDoina RosuIrinel ParepaAdrian MateiTom AlexandruMihaela MalisIoan ComanRodica Stanescu-CioranuDoina DimulescuYury ShvartsOlga OrlikovaZhanna KobalavaOlga BarbarashValentin MarkovNadezhda LyaminaAlexander GordienkoKonstantin ZrazhevskyAlexander VishnevskyVictor GurevichRaisa StryukNikita LomakinIgor BokarevTatiana KhlevchukSergey ShalaevLarisa KhaishevaPetr ChizhovInna ViktorovaNatalya OsokinaVladimir ShchekotovEvgenia AkatovaGalina ChumakovaIgor LibovMikhail VoevodaTatyana TretyakovaEvgeny BaranovSergey ShustovSergey YakushinIvan GordeevNiiaz KhasanovOlga ReshetkoTatiana SotnikovaOlga MolchanovaKonstantin NikolaevLiudmila GaponElena BaranovaZaur ShogenovElena KosmachovaYuriy KarpovAnton PovzunLiudmila EgorovaVadim TyrenkoIgor IvanovMasterov IlyaSergey KanorskyDragan SimicNikola IvanovicGoran DavidovicNebojsa TasicMilika AsaninStevo StojicSvetlana ApostolovicStevan IlicBiljana Putnikovic TosicAleksandar StankovicAleksandra ArandjelovicSlavica RadovanovicBranislava TodicJovan BalinovacDragan DincicPetar SeferovicAna KaradzicSlobodan DodicSinisa DimkovicTamara JakimovKian-Keong PohHean Yee OngJustin Tang I-ShingKarol MickoJan NociarDaniel PellaPeter FulopMarian HranaiJuraj PalkaJuraj MazurIvan MajercákAndrej DzupinaFrantišek FazekasJozef GonsorcikViliam BuganJuraj SeleckyGabriel KamenskyJaroslava StrbovaRudolf SmikAndrej DukatPeter OlexaIvan ŽuranJanez PoklukarNataša Černič ŠuligojMatija CevcHenry CysterNaresh RanjithClive CorbettJunaid BayatEllen Makoali MakotokoHendrik Du Toit TheronIlse KappMatthys de V BassonHanlie LotteringDina van AswegenLouis van ZylPeter SebastianThayabran PillayJan SaaimanPatrick CommerfordSoraya CassimjeeGarda RiazIftikhar EbrahimMahomed SarvanJoseph MynhardtHelmuth ReuterRajendran MoodleyManuel VidaAngel Cequier FillatVicente Bodí PerisFrancisco Fuentes JimenezFrancisco MarínJose Cruz FernándezRafael Jesus Hidalgo UrbanoBlas Gil-ExtremeraPablo ToledoFernando Worner DizDavid Garcia-DoradoAndres IñiguezJosé Tuñón FernándezJose Gonzalez-JuanateyJavier Fernandez PortalesFernando Civeira MurilloLaia Matas PericasJose Luis ZamoranoManuel de Mora MartinJordi Bruguera CortadaJoaquin Alonso MartinJose Maria Serrano AntolinJosé de Berrazueta FernándezJosé Antonio Vázquez de PradaJose Francisco Díaz FernándezJosé Alberto García LledóJuan Cosín SalesJavier Botas RodriguezGabriel Gusi TragantAmparo BenedictoCarlos Gonzalez-JuanateyMercedes Camprubí PotauIgnacio Plaza PerezCésar Morís de La TassaPablo Loma-Osorio RinconJavier Balaguer RecenaJuan EscudierAntonio Coca PayerasNorberto Alonso OrcajoPedro ValdivielsoGodwin ConstantineRuvaiz HaniffaNirmali TisseraStanley AmarasekeraChandrike PonnamperumaNimali FernandoKaputella FernandoJayanthimala JayawardenaSantharaj WijeyasingamGotabhaya RanasingheRuvan EkanayakaSepalika MendisVajira SenaratneGnanamoorthy MayurathanAjantha RajapakshaThilak SirisenaJagath HerathNaomali AmarasenaStefan BerglundGundars RasmanisOla VedinNils WittGeorgios MourtzinisPeter NicolOle HansenStefano RomeoSteen Agergaard JensenIngemar TorstenssonUlf AhremarkTorbjörn SundelinTiziano MoccettiFrancois MachRonald BindeOliver GämperliWei-Chuan TsaiKwo-Chang UengWen-Ter LaiMing-En LiuJuey-Jen HwangWei-Hsian YinI-Chang HsiehMing-Jer HsiehWei Hsiang LinJen-Yuan KuoTsuei-Yuan HuangChih-Yuan FangPinij KaewsuwannaWasant SoonfuangWoravut JintapakornApichard SukonthasarnNattawut WongpraparutKrisada SastravahaNakarin SansanayudhWirash KehasukcharoenDilok PiyayotaiPaiboon ChotnoparatpatAhmet CamsariHakan KultursayBulent MutluMurat ErsanliMustafa DemirtasCevat KirmaErtan UralLale KoldasOleksandr KarpenkoAlexander ProkhorovIhor VakaluykHalyna MyshanychDmytro ReshotkoValeriy BatushkinLeonid RudenkoIhor KovalskyiMykola KushnirVira TseluykoYuriy MostovoyMykola StanislavchukYulian KyiakYuriy KarpenkoYaroslav MalynovskyAndriy KlantsaOles KutniyEkaterina AmosovaViktor TashchukOleh LeshchukMykola RishkoMykola KopytsyaAndriy YagenskyMykola VatutinAndriy BagriyOlga BarnaOlexiy UshakovGeorgiy DzyakBorys GoloborodkoAnatolii RudenkoVolodymyr ZheleznyyJasper TrevelyanAzfar ZamanKaeng LeeAndrew MoriartyRajesh AggarwalPiers CliffordYuk-Ki WongSyed M.R. IqbalEduardas SubkovasDenise BraganzaDavid SarkarRobert StoreyHuw GriffithsSam McclureRangasamy MuthusamySimon SmithJohn KurianTerry LevyCraig BarrHoner KadrRobert GerberAudrius SimaitisHandrean SoranAnthony MathurAdrian BrodisonMohammad AyazMuhammad CheemaRichard OliverSimon ThackrayTelal MudawiGohar RahmanAyyaz SultanTimothy ReynoldsDavid SharmanDavid SprigingsRob ButlerPeter WilkinsonDavid FitzmauriceJulian HalcoxSean GallagherNicholas Ossei-GerningGil VardiDuccio BaldariDavid BrabhamCharles TreasureCharles DahlBruce PalmerAlan WisemanAbul KhanSanjeev PuriAnn Elizabeth MohartCarlos InceEnrique FloresScott WrightShi-Chi ChengMichael RosenbergWilliam RogersEdward KosinskiLes ForgoshJonathan WaltmanMisal KhanMohammad ShoukfehGeorges DagherPatrick CambierIra LieberPriya KumarCara EastPerry KrichmarMian HasanLindsey WhiteThomas KnickelbineThomas HaldisEve GillespieThomas AmidonDavid SuhImran ArifMouhamad AbdallahFaiq AkhterEric CarlsonMichael d'UrsoFadi El-AhdabWilliam NelsonKatie MoriartyBarry HarrisSteven CohenLuther CarterDaniel DotyKenneth SabatinoTariq HaddadAmir MalikSunder RaoAngel MulkayIon JovinKim KlanckeVinay MalhotraSai DevarapalliMichael KorenHarish ChandnaGeorge DoddsTauqir GorayaJames BengstonMatthew JanikJoseph MoranAndrew SumnerJohn KobayashiWilliam DavisShahram YazdaniJohn PasquiniMaitreya ThakkarAmarnath VedereWayne LeimbachJames RiderSarah FentonNarendra SinghAnil ShahDenise JanosikCarl PepineBrett BermanJoseph GelorminiChristopher DanielsKerensky RichardFriederike KeatingNicholas KondoSanjay ShettyHoward LeviteWinfried WaiderTheodore TakataMazen Abu-FadelVipul ShahRahul AggarwalMark IzzoAnil KumarBrack HattlerRose DoChad LinkAnna BortnickGeorge KinzfoglArnold GhitisJohn LarryEdward TeufelPeter KuhlmanBrent MclaurinWenwu ZhangStephen ThewJalal AbbasMatthew WhiteOthman IslamSumeet SubherwalNandkishore RanadiveBabak VakiliChristian GringDavid HendersonTimothy SchuchardNaim FarhatGeoffrey KlineSharan MahalJack WhitakerShawn SpeirsRolf AndersenNizar DaboulPhillip HorwitzFiras ZahrGeorge PonceZubair JafarJoseph McgarveyVipul PanchalStephen VoyceThomas BlokWilliam SheldonMasoud AzizadCarsten SchmalfussMark PiconeRobert PedersonWilliam HerzogKeith FriedmanJason LindseyRosemary NowinsEichenlaub TimothyParilak LeonardNorman LeporMahfouz El ShahawyHoward WeintraubAnand IrimpenAlvaro AlonsoWade MayDaniels ChristopherThomas GalskiAlan ChuFreny ModyEbrahimi RaminZachary HodesJoseph RossiGregory RoseJames FairlambCharles LambertAjit RaisinghaniAntonio AbbateGeorge VetrovecMarilyn KingCharles CareyJaime GerberLiwa YounisHyeun ParkMladen VidovichThomas KnutsonDennis FriedmanFred ChaleffArthur LoussararianPhillip RozemanCarey KimmelstielJeffrey KuvinKevin SilverMalcolm FosterGlen TonnessenAndrey EspinozaMohamadali AmlaniAndreas WaliChristopher MalozziGeert JongClara MasseyKeattiyoat WattanakitPhilip O'DonnellDinesh SingalNaseem JaffraniSridhar BanuruDaniel FisherMark XenakisNeal PerlmutterRavi BhagwatJames StraderRonald BlonderAyim Akyea-DjamsonAjay LabrooKwan LeeH. John MaraisEdmund ClaxtonRobert WeissRohr KathrynMartin BerkPeter RossiParag JoshiAmit KheraAjit KhairaGreg KumkumianSteven LupovitchJoshua PurowStephen WelkaDavid HoffmanStuart FischerEugene SorokaDonald EagertonSamir PancholyMichael RayNorman ErenrichMichael FarrarStewart PollockWilliam FrenchSteve DiamantisDouglas GuyLawrence GimpleMark NeustelSteven SchwartzEdward PereiraSeals AlbertDouglas SpriggsJanet StrainSuneet MittalAnthony VoMajed ChaneJason HallNampalli VijayKapildeo LotunF. Martin LesterAhed NahhasTheodore PopePaul NagerRakesh VohraMukesh SharmaRiyaz BashirHinan AhmedMichael BerlowitzRobert FishbergRobert BarruccoEric YangMichael RadinDaniel SpornDwight StapletonSteven EisenbergJoel LandzbergMartin McgoughSamir TurkMichael SchwartzP. Sandy SundramDiwakar JainMark ZaineaCarlos BayronRonald KarlsbergSuhail DohadHenry LuiWilliam KeenDonald WesterhausenSandeep KhuranaHimanshu AgarwalJessica BirchemWilliam PennyMark ChangSherrill MurphyJohn HenryBranislav Schifferdecker ;john M GilbertGopal ChalavaryaCharles EatonJohn SchmedtjeStuart ChristensonImran DotaniDouglas DenhamAlexander MacdonellJohn Paul GibsonAref RahmanTammam Al JoundiNizar AssiGary ConradPurushotham KothaMichael LoveGregory GieslerHoward RubensteinDawood GamilLaura AkrightJustine KrawczykJoanne CoblerTerry WellsJames WelkerRobert FosterRichard GilmoreJay AndersonDouglas JacobyBill HarrisGeraldine GardnerRamprasad DandillayaKishor VoraJohn KostisJohn HunterDavid LaxsonEric BallFlavia EgydioAnelise KawakamiJanaina OliveiraJulianna WozniakAlexander MatthewsCaroline RatkyJanine ValirisLisa BerdanAnita HepditchKirby QuinteroTyrus RorickMelissa WestbrookAndrea PascualCarla RovitoMadeleine BezaultElodie DrouetTabassome SimonCaroline AlsweilerAnne LuytenJulie ButtersLiddy GriffithMichelle ShawLena GrunbergShahidul IslamMarie-France BrégeaultNathalie BougonDouglas FaustinoSylvie FontecaveJudith MurphyMelanie VerrierVéronique AgnettiDorthe AndersenEmmy BadreddineMhamed BekkoucheCecile BouancheauImane BriguiMaddy BrocklehurstJoseph CianciaruloDawn DevaulSzilvia DomokosCecile GacheCaroline GobillotSeverine GuillouJan HealyMegan HeathGayatri JaiwalCarine JavierreJulien LabeirieMyriam MonierUlises MoralesAsmaa MrabtiBicky MthombeniBetim OkanLucile SmithJennifer ShellerSebastien SopenaValerie PellanFadela BenbernouNafissa BengraitMaud LamoureuxKatarina KralovaRaphael BejuitAnthony CoulangeChristelle BerthouJérôme RepincayChristelle LorenzatoAlexis EtienneValerie GouetVirginie LoizeauMickael NormandAnne OurliacChristelle RondelAntony AdamoPascale BeltranPauline BarraudHelene Dubois-GacheBenjamin HalleLamia MetwallyMaxime MourguesMarc SottyMarion VincendetRaluca CotrutaZhu ChengyueDominique Fournie-LloretChristine MorrelloAurelie PerthuisPatrick PicaultIsabelle ZobouyanHelen ColhounMichael DempseyMark Mcclanahan
• Organismes : University of Colorado [Colorado Springs] State University of New York at New Paltz University of Alabama [Birmingham] University of Toronto St. Michael's Hospital Leiden University Medical Center [Leiden] Charité - UniversitätsMedizin = Berlin University Medicine Berlin Institute of Health Universidad Autónoma de Bucaramanga Regeneron Pharmaceuticals [Tarrytown, NY] Regeneron Pharmaceuticals [Tarrytown, NY] SANOFI Recherche Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials Laboratoire de Recherche Vasculaire Translationnelle Royal Brompton Hospital [London, United Kingdom] Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans Journal of the American College of Cardiology le 26/10/2020

---

Résumé : Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was <70 mg/dL (median 69.4 mg/dL; interquartile range: 64.3-74.0 mg/dL); in 14,573 patients (77.0%), both determinations were ≥70 mg/dL (median 94.0 mg/dL; interquartile range: 83.2-111.0 mg/dL). Results: In the lower LDL-C subgroup, MACE rates were 4.2 and 3.1 per 100 patient-years among placebo-treated patients with baseline lipoprotein(a) greater than or less than or equal to the median (13.7 mg/dL). Corresponding adjusted treatment hazard ratios were 0.68 (95% confidence interval [CI]: 0.52-0.90) and 1.11 (95% CI: 0.83-1.49), with treatment-lipoprotein(a) interaction on MACE (Pinteraction = 0.017). In the higher LDL-C subgroup, MACE rates were 4.7 and 3.8 per 100 patient-years among placebo-treated patients with lipoprotein(a) >13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Jean-Michel NguyenPascal JézéquelPierre GilloisLuisa SilvaFaouda Ben AzzouzSophie Lambert-LacroixPhilippe JuinMario CamponeAurélie GaultierAlexandre Moreau-GaudryDaniel Antonioli
• Organismes : Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Immunology and New Concepts in ImmunoTherapy Institut de Cancérologie de l'Ouest [Angers/Nantes] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 NANTES UNIVERSITÉ - École Centrale de Nantes Institut de Cancérologie de l'Ouest [Angers/Nantes] Université Grenoble Alpes Centre de Recherche en Cancérologie et Immunologie Nantes-Angers Institut de Cancérologie de l'Ouest [Angers/Nantes] CRLCC René Gauducheau Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Medical Informatics [Tournemire, Quartier Bellevue]
• Publié dans Bioinformatics le 25/10/2020

---

Résumé : Abstract Motivation The principle of Breiman's random forest (RF) is to build and assemble complementary classification trees in a way that maximizes their variability. We propose a new type of random forest that disobeys Breiman’s principles and involves building trees with no classification errors in very large quantities. We used a new type of decision tree that uses a neuron at each node as well as an in-innovative half Christmas tree structure. With these new RFs, we developed a score, based on a family of ten new statistical information criteria, called Nguyen information criteria (NICs), to evaluate the predictive qualities of features in three dimensions. Results The first NIC allowed the Akaike information criterion to be minimized more quickly than data obtained with the Gini index when the features were introduced in a logistic regression model. The selected features based on the NICScore showed a slight advantage compared to the support vector machines—recursive feature elimination (SVM-RFE) method. We demonstrate that the inclusion of artificial neurons in tree nodes allows a large number of classifiers in the same node to be taken into account simultaneously and results in perfect trees without classification errors. Availability and implementation The methods used to build the perfect trees in this article were implemented in the ‘ROP’ R package, archived at https://cran.r-project.org/web/packages/ROP/index.html. Supplementary information Supplementary data are available at Bioinformatics online.

---

Fichiers liés : btab074.pdf

---

Source