Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Florian Roisné-HamelinSabrina PobiegaKévin JézéquelSimona MironJordane DépagneXavier VeauteDidier BussoMarie-Hélène Le DuIsabelle CallebautJean-Baptiste CharbonnierPhilippe CuniasseSophie Zinn-JustinStéphane MarcandKeunchil ParkMustafa ÖzgüroğluJohan VansteenkisteDavid SpigelJames C.H. YangHidenobu IshiiMarina GarassinoFilippo de MarinisAleksandra SzczesnaAndreas PolychronisRuchan UsluMaciej KrzakowskiJong-Seok LeeLuana CalabròOsvaldo Arén FronteraHuiling XiongMarcis BajarsMary RuisiFabrice Barlési
• Organismes : Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie Intégrative de la Cellule Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie Intégrative de la Cellule Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de Biologie Intégrative de la Cellule Institut de Biologie Intégrative de la Cellule Institut de Biologie Intégrative de la Cellule Institut de Biologie François JACOB Samsung Medical Center Sungkyunkwan University School of Medicine Istanbul University Cerrahpasa Department of Pulmonology Sarah Cannon Research Institute [Nashville, Tennessee] National Taiwan University Cancer Center [Taipei] IRCCS Istituto Nazionale dei Tumori [Milano] Institut de Recherche Pierre Fabre Seoul National University Bundang Hospital Azienda Ospedaliera Universitaria Senese EMD Serono Research & Development Institute EMD Serono Research & Development Institute Institut Gustave Roussy Centre de Recherche en Cancérologie de Marseille
• Publié dans Journal of Thoracic Oncology le 31/10/2020

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Résumé : Abstract Specific proteins present at telomeres ensure chromosome end stability, in large part through unknown mechanisms. In this work, we address how the Saccharomyces cerevisiae ORC-related Rif2 protein protects telomere. We show that the small N-terminal Rif2 BAT motif ( B locks A ddition of T elomeres) previously known to limit telomere elongation and Tel1 activity is also sufficient to block NHEJ and 5’ end resection. The BAT motif inhibits the ability of the Mre11-Rad50-Xrs2 complex (MRX) to capture DNA ends. It acts through a direct contact with Rad50 ATP-binding Head domains. Through genetic approaches guided by structural predictions, we identify residues at the surface of Rad50 that are essential for the interaction with Rif2 and its inhibition. Finally, a docking model predicts how BAT binding could specifically destabilise the DNA-bound state of the MRX complex. From these results, we propose that when an MRX complex approaches a telomere, the Rif2 BAT motif binds MRX Head in its ATP-bound resting state. This antagonises MRX transition to its DNA-bound state, and favours a rapid return to the ATP-bound state. Unable to stably capture the telomere end, the MRX complex cannot proceed with the subsequent steps of NHEJ, Tel1-activation and 5’ resection.

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Fichiers liés : S1556086421018323.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Julien Gomez-MartinezVincent FoulongneDidier LaureillardNicolas NagotBrigitte MontèsJean-François CantaloubePhilippe van de PerreChantal Fournier-WirthJean-Pierre MolesJean-Charles Brès
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections Hôpital Universitaire Carémeau [Nîmes] Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Talanta le 01/11/2020

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Résumé : Human immunodeficiency virus (HIV) infection is a chronic disease that can be treated with antiretroviral (ARV) therapy. However, the success of this treatment has been jeopardized by the emergence of HIV infections resistant to ARV drugs. In low-to middle-income countries (LMICs), where transmission of resistant viruses has increased over the past decade, there is an urgent need to improve access to HIV drug resistance testing. Here, we present a proof-of-concept study of a rapid and simple molecular method to detect two major mutations (K103 N, Y181C) conferring resistance to first-line nonnucleoside reverse transcriptase inhibitor regimens. Our near-point-of-care (near-POC) diagnostic test, combining a sequence-specific primer extension and a lateral flow DNA microarray strip, allows visual detection of HIV drug resistance mutations (DRM) in a short turnaround time (4 h 30). The assay has a limit of detection of 100 copies of plasmid DNA and has a higher sensitivity than standard Sanger sequencing. The analytical performance was assessed by use of 16 plasma samples from individuals living with HIV-1 and results demonstrated the specificity and the sensitivity of this approach for multiplex detection of the two DRMs in a single test. Furthermore, this near-POC assay could be easily taylored to detect either new DRMs or DRM of from various HIV clades and might be useful for pre-therapy screening in LMICs with high levels of transmitted drug resistance.

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Fichiers liés : S003991402100299X.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Virginie CarmignacCyril MignotEmmanuelle BlanchardPaul KuentzMarie-Hélène Aubriot-LortonVictoria E.R. ParkerArthur SorlinSylvie FraitagJean-Benoît CourcetYannis DuffourdDiana RodriguezRachel KnoxSatyamaanasa PolubothuAnne BolandRobert OlasoMarc DelepineVéronique DarmencyMelissa RiachiChloé QuelinPaul RollierLouise GoujonSarah GrottoYline CapriMarie-Line JacquemontSylvie OdentDaniel AmramMartin ChevarinCatherine Vincent-DelormeBenoît CatteauLaurent GuibaudAlexis ArzimanoglouMalika KeddarCatherine SarretPatrick CallierDidier BessisDavid GenevièveJean‐françois DeleuzeChristel Thauvin-RobinetRobert SempleChristophe PhilippeJean-Baptiste RivièreVeronica KinslerLaurence FaivrePierre Vabres
• Organismes : Institut Pascal
• Publié dans Genetics in Medicine le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Brigitte Tardy-PoncetEmmanuel de MaistreClaire PouplardEmilie PreslesMartine Alhenc-GelasDominique LasneMarie‐hélène HorellouChristine MoutonAnne Serre-SapinAnne BautersPhilippe NguyenFrançois MullierJulien PerrinGrégoire Le GalPierre‐emmanuel MorangeLélia GrunebaumAgnès Lillo-Le LouetIsmail ElalamyYves GruelAndreas GreinacherThomas LecompteBernard Tardy
• Organismes : Santé Ingénierie Biologie Saint-Etienne Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
• Publié dans Journal of Thrombosis and Haemostasis le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Dimitri LaurentChristophe DurletGuillaume BarréPatrick SorriauxPhilippe AudraPierre CartignyCédric CarpentierGuillaume ParisPauline CollonThomas RigaudierJacques PirononEric C Gaucher
• Organismes : GeoRessources Biogéosciences [UMR 6282] Centre scientifique et Technique Jean Feger Laboratoire des Fluides Complexes et leurs Réservoirs Laboratoire de Polytech Nice-Sophia Institut de Physique du Globe de Paris GeoRessources Centre de Recherches Pétrographiques et Géochimiques GeoRessources Centre de Recherches Pétrographiques et Géochimiques GeoRessources Centre scientifique et Technique Jean Feger
• Publié dans Geomorphology le 25/10/2020

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Résumé : Hypogenic caves, linked to carbonate rock dissolution due to CO 2-and H 2 S-rich ascending deep waters, represent more than 10% of karstic networks worldwide; a proportion that increases as these systems are better constrained. However, interaction between hypogenic and epigenic processes is still poorly understood, especially since the subsequent invasion of surface water often obliterates the morphological and mineral markers of hypogenic activities. The Ariège Valley (French Pyrenean foothills) hosts significant karstic networks epigenically reworked by several episodes of glacier meltwater penetration during the successive coverage of Quaternary icefields. Among these karstic systems, the Vapeur and Ermite caves were probably initiated by a hypogenic component during the Miocene. In particular, multipleS , Sr, H, C, and O isotopes of thermo-mineral waters and calcite-sulfate speleothems confirm that hydrothermal fluids reached the caves, and subsequently interacted with Quaternary glacial epigenic phases. Deep fluids conveyed CO 2 and H 2 S, both produced from the thermochemical reduction of Triassic evaporites at depth. H 2 S oxidation and CO 2 hydration in the cave atmosphere, above the water table, created sulfuric and carbonic acids responsible for an intense karstification. Interpretation of isotopic data, together with a geomorphological, mineralogical and textural study of cave minerals, allow us to propose a speleogenetic model in which the respective impact of epigenic and hypogenic processes was driven by base-level changes during successive Quaternary glacial/interglacial epochs: (i) during glacial periods, invasion of glacier meltwater within the karst led to the dilution of the hydrothermal water, and was responsible for an "epigenic mechanical-dominant" speleogenesis through water-related abrasion; (ii) interglacial epochs were marked by base-level drops and the establishment of a vadose domain in caves, favoring the widening of karstic conduits through carbonic and sulfuric acid condensation-corrosion during thermal water degassing. This "hypogenic chemical-dominant" speleogenesis was active until a new advance of glaciers, and this cycle occurred several times.

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Fichiers liés : 2021Pap_LaurentD_Geomorph_Version_Auteur.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Joris GallandBenjamin ThoreauMaxime DelrueMarie NeuwirthAlain StepanianAnthony ChauvinAzeddine DellalOlivier NalletMelanie RorizMathilde DevauxJonathan LondonGonzague Martin-LecampAntoine FroissartNouara ArabBertrand FerronMarie-Helene GroffViviane QueyrelChristine LorutLucile RegardEmilie BerthouxGuillaume BayerCloé ComarmondBertrand LiogerArsène MékinianTali-Anne SzwebelThomas SenéBlanca Amador-BoreiroOlivier ManginPierre-Olivier SellierStephane MoulyJean-Philippe KevorkianVirginie SiguretDominique VodovarDamien SèneMarie‐helene GroffTali‐anne SzwebelPierre‐olivier SellierJean‐philippe KevorkianAlbertini MathieuBouajila SaraBritany KimbimbiBurlacu RuxandraCacoub LéaChampion KarineDelcey VéroniqueDillinger Jean-GuillaumeFeron FlorineFrazier AlineThomas Funck-BretanoGauthier Diane-CecileGautier Jean-FrançoisHenry PatrickHuscenot TessaSarah IzabelMathilde JaulerryJouabli MoenesJulla Jean-BaptisteLaloi Michelin MarieLeroy PierreLopes AmandaBruno MégarbaneMichon MaximeMunier Anne-LiseNahmani YoramNicol MartinNicolas EroanPoulat AudreyRevue EricRichette PascalRiveline Jean-PierreRubenstein EmmaZanin AdrienAveneau ClémentBastard PaulBeauvais DianeBoghez LoredanaBorderiou AlixConway PaulCosma LavigniaDavy VincentDesjardin ClémentDevatine SandraDucroz Gerardin ChristelDupe CharlotteGobert ChloéGros ClotildeKadiri SoumayaKhan EnmatOngnessek SandrineRhmari FatimaSacco IsabelleSaptefrat NataliaSchaupp PaulineJustine SerreSideris GeorgiosSmati SoniaTournier MarineTreca PaulineTruong TonyTuffier MathildeArcelli MattéoBoue YvonnickCopie AlbanDeye NicolasEkherian Jean-MichelErrabih ZaccariaGonde AntoineGrant CarolineGuerin EmmanuelleMagalhaes AdèleMalissin IsabelleMeurisse EdouardMrad AymenNaim GiuliaNguyen PhilippeNitenberg KiyokoPepin‐lehalleur AdrienPerault ArthurPerrin LucileRenaud MaximeSutterlin LaetitiaDelrue MaximeSiguret VirginieStepanian Alain
• Organismes : Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans European Journal of Haematology le 22/10/2020

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Résumé : A high prevalence of pulmonary embolism (PE) has been described during COVID-19. Our aim was to identify predictive factors of PE in non-ICU hospitalized COVID-19 patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Aurélien CuchetAnthony AnchisiPhilippe TéloukYijiao YaoFrédéric SchietsFrançois FourelYohann ClémentPierre LantériElise CaréniniPatrick JameHervé Casabianca
• Organismes : ISA-PNBS - Produits naturels et biosourcés - Natural & Bio-based Products Albert Vieille SAS ISA-Isotopique & Organique - Isotopic & Organic Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement ISA-PNBS - Produits naturels et biosourcés - Natural & Bio-based Products LEHNA - Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés [équipe E3S] Chemometrics and theoretical chemistry. - Chimiométrie et chimie théorique Chemometrics and theoretical chemistry. - Chimiométrie et chimie théorique Albert Vieille SAS ISA-Isotopique & Organique - Isotopic & Organic ISA-PNBS - Produits naturels et biosourcés - Natural & Bio-based Products
• Publié dans Food Control le 24/10/2020

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Fichiers liés : S0956713521002243.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Sydney DuboisPhilippe RuminyElodie BohersPierre‐julien ViaillyLiana VeresezanJean‐michel PicquenotVictor BobéeMathieu ViennotDominique PentherVincent CamusCatherine ThieblemontCamille PouatyHervé TillyFabrice Jardin
• Organismes : Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Hopital Saint-Louis [AP-HP] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
• Publié dans Clinical Case Reports le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Alexandre GodonCharles Ambroise TacquardAlexandre MansourDelphine GarriguePhilippe NguyenDominique LasneSophie TestaJerrold LevyPierre AlbaladejoYves GruelSophie SusenAnne GodierPierre AlbaladejoN. BlaisF. BonhommeAnnie Borel-DerlonAriel CohenJ.-P. ColletE. de MaistreP. FontanaD. Garrigue HuetAnne GodierYves GruelAlexandre GodonB. IckxSilvy LaporteDominique LasneJ. LlauG. Le GalT. LecompteS. LessireJ.H. LevyD. LongroisS. Madi-JebaraAlexandre MansourM. MazighiPatrick MismettiP.E. MorangeS. MotteF. MullierN. NathanPhilippe NguyenGilles PernodN. RosencherS. RoulletP.M. RoyS. SchlumbergerP. SiéA. SteibSophie SusenC.A. TacquardSophie TestaA. VincentelliP. ZuffereyA. Borel-DerlonE BoissierB DumontE. de MaistreYves GruelC JamesDominique LasneT. LecompteP.E. MorangePhilippe NguyenP. SiéVirginie SiguretSophie Susen
• Organismes : BrainTech Laboratory [CHU Grenoble Alpes - Inserm U1205] Hôpitaux Universitaires de Strasbourg Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital universitaire Robert Debré [Reims] Hôpital Necker - Enfants Malades [AP-HP] Istituti Ospitalieri di Cremona Duke University [Durham] Centre Hospitalier Universitaire [CHU Grenoble] CHU Trousseau [Tours] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Universitaire [CHU Grenoble] Institut des Sciences de l'Evolution de Montpellier Association française des hémophiles Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Saint-Antoine [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Dijon Federal Institute for Materials Research and Testing - Bundesanstalt für Materialforschung und -prüfung Hôpital Européen Georges Pompidou [APHP] CHU Trousseau [Tours] BrainTech Laboratory [CHU Grenoble Alpes - Inserm U1205] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne Hémostase, Inflammation, Thrombose Groupe d'Etude de la Thrombose de Bretagne Occidentale Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Université de Genève = University of Geneva CHU UCL Namur AP-HP - Hôpital Bichat - Claude Bernard [Paris] Université Paris Cité Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Fondation Ophtalmologique Adolphe de Rothschild [Paris] Laboratoire de Recherche Vasculaire Translationnelle Hôpital Lariboisière-Fernand-Widal [APHP] FHU NeuroVasc [Site Sainte-Anne, Paris] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne CHU UCL Namur CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique Hôpital universitaire Robert Debré [Reims] Université Grenoble Alpes - UFR Médecine Service d'anesthésie-réanimation [Hôtel-Dieu] Université de Bordeaux Centre Hospitalier Universitaire de Toulouse Exail (iXblue) Centre Hospitalier Régional Universitaire [CHU Lille] Santé Ingénierie Biologie Saint-Etienne Association française des hémophiles CHU Dijon CHU Trousseau [Tours] Hôpital universitaire Robert Debré [Reims] Service d’Hématologie Biologique [CHU Lariboisière] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Jean Philippe HerbeuvalClaude LambertOdile SabidoMichèle CottierPierre FournelMichel DyChristian Genin
• Organismes : Institut National de la Santé et de la Recherche Médicale
• Publié dans Cytokine le 31/10/2020

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Résumé : Type I interferons are essential for host response to viral infections, while dysregulation of their response can result in autoinflammation or autoimmunity. Among IFNα (alpha) responses, 13 subtypes exist that signal through the same receptor, but have been reported to have different effector functions. However, the lack of available tools for discriminating these closely related subtypes, in particular at the protein level, has restricted the study of their differential roles in disease. We developed a digital ELISA with specificity and high sensitivity for the IFNα2 subtype. Application of this assay, in parallel with our previously described pan-IFNα assay, allowed us to study different IFNα protein responses following cellular stimulation and in diverse patient cohorts. We observed different ratios of IFNα protein responses between viral infection and autoimmune patients. This analysis also revealed a small percentage of autoimmune patients with high IFNα2 protein measurements but low pan-IFNα measurements. Correlation with an ISG score and functional activity showed that in this small sub group of patients, IFNα2 protein measurements did not reflect its biological activity. This unusual phenotype was partly explained by the presence of anti-IFNα auto-antibodies in a subset of autoimmune patients. This study reports ultrasensitive assays for the study of IFNα proteins in patient samples and highlights the insights that can be obtained from the use of multiple phenotypic readouts in translational and clinical studies.

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