Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 21/08/2021
• Auteurs : Raphael Romano BrunoBernhard WernlyHans FlaattenJesper FjølnerAntonio ArtigasBernardo Bollen PintoJoerg C SchefoldStephan BinnebösselPhilipp Heinrich BaldiaMalte KelmMichael BeilSivri SigalPeter Vernon Van HeerdenWojciech SzczeklikMuhammed ElhadiMichael JoannidisSandra OeyenTilemachos ZafeiridisJakob WollbornMaria José Arche BanzoKristina FuestBrian MarshFinn H AndersenRui MorenoSusannah LeaverAriane BoumendilDylan W De LangeBertrand GuidetChristian JungPhilipp EllerMichael JoannidisDieter MesottenPascal ReperSandra OeyenWalter SwinnenNicolas SerckElisabeth DewaeleEdwin ChapetaHelene BrixJens BrushoejPritpal KumarHelene Korvenius NedergaardTim Koch JohnsenCamilla BundesenMaria Aagaard HansenStine UhrenholtHelle BundgaardJesper FjølnerRichard InnesJames GoochLenka CagovaElizabeth PotterMichael ReayMiriam DaveyMohammed Abdelshafy AbusayedSally HumphreysAmy CollinsAvinash AujayebSusannah LeaverWaqas KhaliqAyman Abdelmawgoad HabibMohammed A AzabKyrillos WassimYumna A ElgazzarRehab SalahHazem Maarouf AbosheaishaaAliae a R Hussein MohamedAhmed Y AzzamSamar TharwatYasmin Khairy Nasreldin Mohamed AliOmar ElmandouhIslam GalalAhmed Abu-ElfatthKaram MotaweaMohammad ElbahnasawyMostafa ShehataMohamed ElbahnasawyMostafa TayebNermin OsmanWafaa Abdel-ElsalamAliae Mohamed HusseinAmer AldhaliaArnaud GalboisBertrand GuidetCyril CharronCaroline Hauw BerlemontGuillaume BeschJean-Philippe RigaudJulien MaizelMichel DjibréPhilippe BurtinPierre GarconSaad NseirXavier ValetteNica AlexandruNathalie MarinMarie VaissiereGaëtan PlantefeveHervé MentecThierry VanderlindenIgor JurcisinBuno MegarbaneBenjamin ChoustermanFrançois DépretMarc GarnierSebastien BessetJohanna OzielAlexis FerreStéphane DaugerGuillaume DumasBruno GoncalvesLucie VettorettiDidier TheveninStefan SchallerMuhammed KurtAndreas FaltlhauserChristian MeyerMilena MilovanovicMatthias LutzGonxhe ShalaHendrik HaakeWinfried RanderathAnselm KunsteinPatrick MeybohmStephan SteinerEberhard BarthTudor PoernerPhilipp SimonMarco LorenzZouhir DindaneKarl Friedrich KuhnMartin WelteIngo VoigtHans-Joachim KabitzJakob WollbornUlrich GoebelSandra Emily StollDetlef Kindgen-MillesSimon DublerChristian JungKristina FuestMichael SchusterStephan SteinerAntonios PapadogoulasFrancesk MulitaNikoletta RovinaZoi AidoniEvangelia ChrisanthopoulouEumorfia KondiliIoannis AndrianopoulosMohan GurjarAta MahmoodpoorRand HusseinMaytham Aqeel Al-JuaifariAbdullah Khudhur Ahmed KarantenachySigal SviriAhmed ElsakaBrian MarshVittoria ComelliniFarah Al-AliSari AlmaniAlmu' Atasim KhameesKhayry Al-ShamiIbrahim Salah El DinTaha AbubakerHazem AhmedAhmed RabhaAbdulmueti AlhadiMarwa EmhamedSaedah AbdeewiAbdurraouf AbusalamaAbdulmueti AlhadiMohammed HuwayshEsraa Abdalqader AlghatiAbdelilah GhannamSilvio A Namendys-SylvaMartijn GroenendijkMirjam EversLenneke Van Lelyveld-HaasIwan MeynaarAlexander Daniel CornetMarieke ZegersWillem DieperinkDylan De LangeTom DormansMichael HahnBritt SjøbøeHans Frank StrietzelTheresa OlasveengenLuis RomundstadFinn H AndersenJohn George Grace MassoudAamir Ghafoor KhanShahd Al-QasrawiSarah AmroAnna KluzikPaweł ZatorskiTomasz DrygalskiWojciech SzczeklikJakub KlimkiewiczJoanna Solek-PastuszkaDariusz OnichimowskiMiroslaw CzuczwarRyszard GawdaJan StefaniakKarina Stefanska-WronkaEwa ZabulAna Isabel Pinho OliveiraRui AssisMaria de Lurdes Campos SantosHenrique SantosFilipe Sousa CardosoAndré GordinhoIoana Marina GrintescuDana TomescuMohamed Raafat BadawyM José Arche BanzoBegoña Zalba-EtayoPatricia Jimeno CuberoJesús PriegoGemma GomàTeresa Maria Tomasa-IrriguibleSusana SanchoAida Fernández FerreiraEric Mayor VázquezÁngela Prado MiraMercedes IbarzDavid IglesiasSusana Arias-RiveraFernando Frutos-VivarSonia Lopez-CuencaCesar AldecoaDavid Perez-TorresIsabel Canas-PerezLuis Tamayo-LomasCristina Diaz-RodriguezPablo Ruiz De GopeguiMahmoud SalehMomin Majed Yousuf HillesEnas M Y AbualqumbozNawfel Ben-HamoudaAndrea RobertiYvan FleuryNour AbidiJoerg C SchefoldIvan ChauAlexander DullenkopfMohammad Karam ChaabanMohammed Mouaz ShebaniAhmad HmaidehAymen ShaherAyca Sultan SahinKemal Tolga SaracogluMohammed Al-SadawiRichard PughSara SmutsRafat Ameen Mohammed Al-Saban
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have been mostly affected during the initial surge in 2020. Methods: This prospective international observation study (The COVIP study) recruited patients aged 70 years or older (ClinicalTrials.gov ID: NCT04321265) admitted to an intensive care unit (ICU) with COVID-19 disease from March 2020 to February 2021. In addition to serial lactate values (arterial blood gas analysis), we recorded several parameters, including SOFA score, ICU procedures, limitation of care, ICU- and 3-month mortality. A lactate concentration ≥ 2.0 mmol/L on the day of ICU admission (baseline) was defined as abnormal. The primary outcome was ICU-mortality. The secondary outcomes 30-day and 3-month mortality. Results: In total, data from 2860 patients were analyzed. In most patients (68%), serum lactate was lower than 2 mmol/L. Elevated baseline serum lactate was associated with significantly higher ICU- and 3-month mortality (53% vs. 43%, and 71% vs. 57%, respectively, p < 0.001). In the multivariable analysis, the maximum lactate concentration on day 1 was independently associated with ICU mortality (aOR 1.06 95% CI 1.02-1.11; p = 0.007), 30-day mortality (aOR 1.07 95% CI 1.02-1.13; p = 0.005) and 3-month mortality (aOR 1.15 95% CI 1.08-1.24; p < 0.001) after adjustment for age, gender, SOFA score, and frailty. In 826 patients with baseline lactate ≥ 2 mmol/L sufficient data to calculate the difference between maximal levels on days 1 and 2 (∆ serum lactate) were available. A decreasing lactate concentration over time was inversely associated with ICU mortality after multivariate adjustment for SOFA score, age, Clinical Frailty Scale, and gender (aOR 0.60 95% CI 0.42-0.85; p = 0.004). Conclusion: In critically ill old intensive care patients suffering from COVID-19, lactate and its kinetics are valuable tools for outcome prediction.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/08/2021
• Auteurs : Boris JungClément Le BihanPierre PortalesNathalie BourgeoisThierry VincentLaurence LachaudGerald ChanquesMatthieu ConseilPhilippe CornePablo MassanetJean François TimsitSamir Jaber
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes CIC - CHU Bichat Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Background Precision medicine risk stratification is desperately needed to both avoid systemic antifungals treatment delay and over prescription in the critically ill with risk factors. The aim of the present study was to explore the combination of host immunoparalysis biomarker (monocyte human leukocyte antigen-DR expression (mHLA-DR)) and Candida sp wall biomarker β- d -glucan in risk stratifying patients for secondary invasive Candida infection (IC). Methods Prospective observational study. Two intensive care units (ICU). All consecutive non-immunocompromised septic shock patients. Serial blood samples ( n = 286) were collected at day 0, 2 and 7 and mHLA-DR and β- d -glucan were then retrospectively assayed after discharge. Secondary invasive Candida sp infection occurrence was then followed at clinicians’ discretion. Results Fifty patients were included, 42 (84%) had a Candida score equal or greater than 3 and 10 patients developed a secondary invasive Candida sp infection. ICU admission mHLA-DR expression and β- d -glucan (BDG) failed to predict secondary invasive Candida sp infection. Time-dependent cause-specific hazard ratio of IC was 6.56 [1.24–34.61] for mHLA-DR < 5000 Ab/c and 5.25 [0.47–58.9] for BDG > 350 pg/mL. Predictive negative value of mHLA-DR > 5000 Ab/c and BDG > 350 pg/mL combination at day 7 was 81% [95% CI 70–92]. Conclusions This study suggests that mHLA-DR may help predicting IC in high-risk patients with septic shock. The added value of BDG and other fungal tests should be regarded according to the host immune function markers.

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Fichiers liés : s13613-021-00918-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/08/2021
• Auteurs : Vincent CavalRodolphe SuspènePierre KhalfiJulien GaillardGrégory CaignardDamien VitourPhilippe RoingeardJean Pierre VartanianSimon Wain-Hobson
• Organismes : Rétrovirologie Moléculaire Rétrovirologie Moléculaire Rétrovirologie Moléculaire Ecole Doctorale Complexité du Vivant Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents Plateforme IBISA de Microscopie Electronique [CHRU de Tours] Virologie UMR1161 Virologie UMR1161 Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents Plateforme IBISA de Microscopie Electronique [CHRU de Tours] Rétrovirologie Moléculaire Rétrovirologie Moléculaire
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : The human APOBEC3A (A3A) cytidine deaminase is a powerful DNA mutator enzyme recognized as a major source of somatic mutations in tumor cell genomes. However, there is a discrepancy between APOBEC3A mRNA levels after interferon stimulation in myeloid cells and A3A detection at the protein level. To understand this difference, we investigated the expression of two novel alternative "A3Alt" proteins encoded in the +1-shifted reading frame of the APOBEC3A gene. A3Alt-L and its shorter isoform A3Alt-S appear to be transmembrane proteins targeted to the mitochondrial compartment that induce membrane depolarization and apoptosis. Thus, the APOBEC3A gene represents a new example wherein a single gene encodes two pro-apoptotic proteins, A3A cytidine deaminases that target the genome and A3Alt proteins that target mitochondria.

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Fichiers liés : 1-s2.0-S002192582100884X-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 13/08/2021
• Auteurs : François MuratetElisa TeyssouAude ChiotSéverine BoilléeChristian S. LobsigerDelphine BohlBeata GyorgyJustine GueganYannick MarieMaria-Del-Mar AmadorFrancois SalachasVincent MeiningerEmilien BernardJean-Christophe AntoineJean- Philippe CamdessanchéWilliam CamuCécile CazeneuveAnne-Laure Fauret-AmsellemEric LeguernKevin MouzatClaire GuissartSerge LumbrosoPhilippe CorciaPatrick Vourc’hAude-Marie GrapperonShahram AttarianAnnie VerschuerenDanielle SeilheanStéphanie Millecamps
• Organismes : Institut du Cerveau = Paris Brain Institute Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Hôpital privé des Peupliers (Paris) Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre Sclérose Latérale Amyotrophique et maladies du motoneurone [CHU Saint-Etienne] Centre Sclérose Latérale Amyotrophique et maladies du motoneurone [CHU Saint-Etienne] Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Centre Hospitalier Universitaire de Nîmes Institut des Neurosciences de Montpellier Institut des Neurosciences de Montpellier Centre Hospitalier Universitaire de Nîmes Institut des Neurosciences de Montpellier Centre Hospitalier Universitaire de Nîmes Centre de compétence de la Sclérose Latérale Amyotrophique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : Objective Mutations in superoxide dismutase 1 gene ( SOD1) , encoding copper/zinc superoxide dismutase protein, are the second most frequent high penetrant genetic cause for amyotrophic lateral sclerosis (ALS) motor neuron disease in populations of European descent. More than 200 missense variants are reported along the SOD1 protein. To limit the production of these aberrant and deleterious SOD1 species, antisense oligonucleotide approaches have recently emerged and showed promising effects in clinical trials. To offer the possibility to any patient with SOD1-ALS to benefit of such a gene therapy, it is necessary to ascertain whether any variant of unknown significance (VUS), detected for example in SOD1 non-coding sequences, is pathogenic. Methods We analysed SOD1 mutation distribution after SOD1 sequencing in a large cohort of 470 French familial ALS (fALS) index cases. Results We identified a total of 27 SOD1 variants in 38 families including two SOD1 variants located in nearsplice or intronic regions of the gene. The pathogenicity of the c.358–10T>G nearsplice SOD1 variant was corroborated based on its high frequency (as the second most frequent SOD1 variant) in French fALS, the segregation analysis confirmed in eight affected members of a large pedigree, the typical SOD1-related phenotype observed (with lower limb onset and prominent lower motor neuron involvement), and findings on postmortem tissues showing SOD1 misaccumulation. Conclusions Our results highlighted nearsplice/intronic mutations in SOD1 are responsible for a significant portion of French fALS and suggested the systematic analysis of the SOD1 mRNA sequence could become the method of choice for SOD1 screening, not to miss these specific cases.

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Fichiers liés : Muratet et al. - 2021 - Impact of a frequent nearsplice SOD1 variant in am.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 09/08/2021
• Auteurs : Sarah BaillyVanessa MachaultSamuel BeneteauPhilippe PalanyRomain GirodJean-Pierre LacauxPhilippe QuenelClaude Flamand
• Organismes : Unité d'Epidémiologie [Cayenne, Guyane française] Laboratoire d'aérologie Unité d'Epidémiologie [Cayenne, Guyane française] Direction Inter-Régionale des Antilles-Guyane Entomologie médicale [Cayenne, Guyane française] Institut Pasteur de Madagascar Laboratoire d'aérologie Institut de recherche en santé, environnement et travail Entomologie médicale [Cayenne, Guyane française] Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases

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Résumé : Although the development of vaccines for the prevention of arboviral diseases has been a priority in recent years, prevention strategies continue to depend on vector control. Risk maps at scales appropriate for these strategies can provide valuable information to assess entomological risk levels and guide actions. We used a spatio-temporal modeling approach to predict, at the local scale, the risk of homes potentially harboring Aedes aegypti larvae. The model used integrated larvae risk data collected in the field from September 2011 to February 2013, environmental data obtained from very high spatial resolution Pleiades imagery, and daily meteorological data, collected in the city of Matoury in French Guiana. Various environmental and meteorological conditions were identified as risk or protective factors for the presence of immature stages of Aedes aegypti in homes on a given date and used to produce dynamic maps with high spatial and temporal resolution. Aedes vector risk was modeled between 50 and 200 m, around houses, on a time scale of 3 to 5 days. The resulting model was extrapolated to other municipalities with the same characteristics of urbanization during the 2019-2020 dengue epidemic in French Guiana. This work represents a major opportunity to monitor the evolution of vector risk and constitutes information that could be particularly useful for public health authorities in charge of vector control.

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Fichiers liés : 2021.08.02.21261373v1.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 09/08/2021
• Auteurs : Minh Thuong KhongValerie Berl BauderLauriane KuhnPhilippe HammannJean-Pierre Lepoittevin
• Organismes : Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg
• Publié dans Chemical Research in Toxicology le 29/10/2020

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Résumé : Chemical skin and respiratory allergies are becoming a major health problem. To date our knowledge on the process of protein haptenation is still limited and mainly derived from studies performed in solution using model nucleophiles. In order to better understand chemical interactions between chemical allergens and the skin, we have investigated the reactivity of phthalic anhydride 1 (PA), a chemical respiratory sensitizer, towards reconstructed human epidermis (RHE). This study was performed using a new approach combining HRMAS NMR to investigate the in situ chemical reactivity and LC-MS/MS to identify modified epidermal proteins. In RHE, the reaction of PA appeared to be quite fast and the major product formed was phthalic acid. Two amide type adducts on lysine residues were observed and after 8h of incubation, we also observed the formation of an imide type cyclized adducts with lysine. In parallel, RHE samples topically exposed to phthalic anhydride (13C)-1 were analyzed using the shotgun proteomics method. Thus, 948 different proteins were extracted and identified, 135 of which being modified by PA i.e. 14.2% of the extracted proteome. A total of 211 amino acids were modified by PA and validated by fragmentation spectra. We thus identified 154 modified lysines ,22 modified histidines , 30 modified tyrosines and 5 modified arginines. The rate of modified residues, as a proportion of the total number of modifiable nucleophilic residues in RHE, was rather low (1%). At the protein level, modified proteins were mainly type I and type II keratins and other proteins which are abundant in the epidermis such as protein S100A, Caspase 14, annexin A2, serpin B3, Fatty-acid binding protein 5, histone H2, H3, H4 etc. However, the most modified protein, mainly on histidine residues, was filaggrin, a protein that is of low abundance (0.0266 mol%) and rich in histidine.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/08/2021
• Auteurs : Albert RilliardPhilippe Boula de MareüilFrédéric VernierJean-Pierre Lai
• Organismes : Traitement du Langage Parlé - LISN Laboratoire Interdisciplinaire des Sciences du Numérique Traitement du Langage Parlé - LISN Laboratoire Interdisciplinaire des Sciences du Numérique Analysis and Visualization Laboratoire Interdisciplinaire des Sciences du Numérique GIPSA-Services GIPSA - SYstèmes Linguistiques, Dialectologie et Oralité

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• Type de publi. : Article dans une revue
• Date de publi. : 06/08/2021
• Auteurs : Marta Andrea SiragusaThomas RufinRobert CourtoisCatherine BelzungFrédéric AnderssonBruno BrizardPaul-Armand DujardinJean-Philippe CottierFrédéric PatatJean-Pierre RemenierasValérie GissotWissam El-HageVincent CamusThomas Desmidt
• Organismes : Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Qualité de vie et Santé psychologique Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Centre d’Investigation Clinique [Tours] CIC 1415 Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Centre d’Investigation Clinique [Tours] CIC 1415 Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours
• Publié dans Brain imaging and behavior (Brain Imaging Behav) le 28/10/2020

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Résumé : Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (n = 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.

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Fichiers liés : Left amygdala volume and brain tissue pulsatility are associated with neuroticism an MRI and ultrasound study.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/08/2021
• Auteurs : Frédéric JacobThomas H.G. VidalAudrey LesaignouxAlbert OliosoMarie WeissFrançoise NerryStéphane JacquemoudPhilippe GametKarine CaillaultLuc LabarreAndrew FrenchThomas SchmuggeXavier BriottetJean-Pierre Lagouarde
• Organismes : Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Analytic and Computational Research, Inc. - Earth Sciences Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Institut de Physique du Globe de Paris Centre d'études spatiales de la biosphère DOTA, ONERA, Université Paris Saclay [Palaiseau] DOTA, ONERA, Université Paris Saclay [Palaiseau] USDA Agricultural Research Service [Maricopa, AZ] Northwest Missouri State University DOTA, ONERA, Université de Toulouse [Toulouse] Interactions Sol Plante Atmosphère
• Publié dans IEEE Transactions on Geoscience and Remote Sensing le 31/10/2020

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Résumé : In preparation of the micro-bolometer based MIcro Satellite for Thermal Infrared GRound surface Imaging (MIST-IGRI) mission, we study the error budget of the Temperature-Emissivity Separation (TES) method using several spectral configurations that differ in channel numbers, locations, and widths. The error budget quantifies the contribution of (1) the TES underlying assumption about emissivity spectral contrast, (2) the errors on atmospheric corrections, and (3) the instrumental noise. When dealing with atmospheric corrections, we consider errors on atmospheric temperature, water vapor content, and concentrations of CO2 and O3. To that end, we design an end-to-end simulator of MISTIGRI measurements in order to simulate the radiative and biophysical quantities involved in the data processing. We conduct numerous simulations over a wide range of realistic setups that include cavity effect, i.e., radiance trapping within vegetation canopy. In the case of micro-bolometer based sensing, the current study highlights that atmospheric and instrumental noises have similar impacts on the TES retrievals, with resulting errors twice as large as those due to the TES intrinsic assumption about spectral contrast, where the latter contributes to the TES error budget within the [0.005-0.009] interval for emissivity, and within the [0.3 K-0.4 K] interval for LST. Also, we show that retrieval performances of surface temperature are very similar across all considered MISTIGRI spectral configurations, with RMSE variation within 0.2 K.

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Fichiers liés : z50-oa-file2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Quentin LisanThomas T van SlotenPierre BoutouyrieStéphane LaurentNicolas DanchinFrédérique ThomasCatherine GuiboutMarie‐cécile PerierPieter DagnelieRonald HenryMiranda SchramRaphaël HeinzerPedro Manuel Marques-VidalCarla van der KallenHarry CrijnsMarleen van GreevenbroekKoen ReesinkSebastian KöhlerManuel SastryXavier JouvenCoen StehouwerJean‐philippe Empana
• Organismes : Paris-Centre de Recherche Cardiovasculaire
• Publié dans Journal of the American Heart Association le 28/10/2020

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Résumé : Background The mechanisms underlying the association between obstructive sleep apnea (OSA) and cardiovascular disease may include accelerated vascular aging. The aim was to compare the magnitude of vascular aging in patients with high versus low risk of OSA. Methods and Results In 2 community‐based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study, high risk of OSA was determined with the Berlin questionnaire (a screening questionnaire for OSA). We assessed carotid artery properties (carotid intima‐media thickness, Young’s elastic modulus, carotid‐femoral pulse wave velocity, carotid pulse wave velocity, carotid diameter using high precision ultrasound echography), and carotid‐femoral pulse wave velocity (in the Maastricht Study only). Regression coefficients were estimated on pooled data using multivariate linear regression. A total of 8615 participants without prior cardiovascular disease were included (6840 from PPS3, 62% men, mean age 59.5±6.2 years, and 1775 from the Maastricht Study, 51% men, 58.9±8.1 years). Overall, high risk of OSA prevalence was 16.8% (n=1150) in PPS3 and 23.8% (n=423) in the Maastricht Study. A high risk of OSA was associated with greater carotid intima‐media thickness (β=0.21; 0.17–0.26), Young’s elastic modulus (β=0.21; 0.17–0.25), carotid‐femoral pulse wave velocity (β=0.24; 0.14–0.34), carotid pulse wave velocity (β=0.31; 0.26–0.35), and carotid diameter (β=0.43; 0.38–0.48), after adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site. Consistent associations were observed after additional adjustments for mean blood pressure, body mass index, or antihypertensive medications. Conclusions These data lend support for accelerated vascular aging in individuals with high risk of OSA. This may, at least in part, underlie the association between OSA and cardiovascular disease.

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