Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Amira BouzidiLabreche KarimMarine BaronMarianne VeyriJérôme Alexandre DenisMehdi TouatMarc SansonFrédéric DaviErell GuillermStéphanie JouannetFrédéric CharlotteFranck BielleSylvain ChoquetPierre-Yves BoëlleJacques CadranelVéronique LeblondBrigitte AutranJean-Marc LacorteJean-Philippe SpanoFlorence Coulet
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Biologie et thérapeutiques du cancer [CRSA] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Instabilité des microsatellites et cancers [CRSA] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Frontiers in Cell and Developmental Biology le 22/10/2020

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Résumé : Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect genomic abnormalities by directly testing a blood sample. This method is particularly useful for immunosuppressed patients, who are at high risk of complications from tissue biopsy. The cfDNA tumor fraction (TF) varies greatly across cancer type and between patients. Thus, the detection of molecular alterations is highly dependent on the circulating TF. In our study, we aimed to calculate the TF and characterize the copy number aberration (CNA) profile of cfDNA from patients with rare malignancies occurring in immunosuppressed environments or immune-privileged sites. To accomplish this, we recruited 36 patients: 19 patients with non-Hodgkin lymphoma (NHL) who were either human immunodeficiency virus (HIV)-positive or organ transplant recipients, 5 HIV-positive lung cancer patients, and 12 patients with glioma. cfDNA was extracted from the patients’ plasma and sequenced using low-coverage whole genome sequencing (LC-WGS). The cfDNA TF was then calculated using the ichorCNA bioinformatic algorithm, based on the CNA profile. In parallel, we performed whole exome sequencing of patient tumor tissue and cfDNA samples with detectable TFs. We detected a cfDNA TF in 29% of immune-suppressed patients (one patient with lung cancer and six with systemic NHL), with a TF range from 8 to 70%. In these patients, the events detected in the CNA profile of cfDNA are well-known events associated with NHL and lung cancer. Moreover, cfDNA CNA profile correlated with the CNA profile of matched tumor tissue. No tumor-derived cfDNA was detected in the glioma patients. Our study shows that tumor genetic content is detectable in cfDNA from immunosuppressed patients with advanced NHL or lung cancer. LC-WGS is a time- and cost-effective method that can help select an appropriate strategy for performing extensive molecular analysis of cfDNA. This technique also enables characterization of CNAs in cfDNA when sufficient tumor content is available. Hence, this approach can be used to collect useful molecular information that is relevant to patient care.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Gregory SchwartzMichael SzarekVera BittnerRafael DiazShaun GoodmanJ Wouter JukemaUlf LandmesserPatricio López-JaramilloGaren ManvelianRobert PordyMichel ScemamaPeter SinnaeveHarvey WhitePhilippe Gabriel StegJ. Wouter JukemaDeepak BhattRobert HarringtonAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefWilliam SasielaJean-François TambyPhilip AylwardHeinz DrexelMirza DilicRenato LopesNina GotchevaJuan-Carlos PrietoHuo YongIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo Carlos Montenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisDavid MaronJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicÉtienne PuymiratWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio JureJulio O.E. 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SyLouie TiradorGeneroso MatigaRaul Martin CochingAlisa BernanGregorio RogelioDante MoralesEdgar TanDennis Jose SulitAdrian WlodarczakKrystyna JaworskaGrzegorz SkoniecznyLidia PawlowiczPawel WojewodaBenita Busz-PapiezJanusz BednarskiAleksander GochPawel StanetaElzbieta DulakKrzysztof SaminskiWlodzimierz KrasowskiWanda SudnikAleksander ZurakowskiMarcin SkorskiRoman LysekBeata MiklaszewiczJacek KubicaJan Andrzej LipkoEdyta Kostarska-SrokoszMarek PiepiorkaAnna DrzewieckaRyszard SciborskiArkadiusz StasiewskiTomasz BlicharskiLeszek BystrykMichal SzpajerMarek KorolTomasz CzerskiEwa Mirek-BryniarskaJacek GniotAndrzej LubinskiJerzy GornyEdward FranekGrzegorz RaczakHanna SzwedPedro MonteiroJose Mesquita BastosHelder PereiraDinis MartinsFilipe SeixoCarlos MendonçaAna BotelhoFrancisca CaetanoBogdan MinescuOctavian IstratoaieDan TesloianuGabriel CristianSilviu DumitrescuCristian G.C. PodoleanuMircea C.A. ConstantinescuCristina BengusConstantin MilitaruDoina RosuIrinel ParepaAdrian MateiTom AlexandruMihaela MalisIoan ComanRodica Stanescu-CioranuDoina DimulescuYury ShvartsOlga OrlikovaZhanna KobalavaOlga BarbarashValentin MarkovNadezhda LyaminaAlexander GordienkoKonstantin ZrazhevskyAlexander VishnevskyVictor GurevichRaisa StryukNikita LomakinIgor BokarevTatiana KhlevchukSergey ShalaevLarisa KhaishevaPetr ChizhovInna ViktorovaNatalya OsokinaVladimir ShchekotovEvgenia AkatovaGalina ChumakovaIgor LibovMikhail VoevodaTatyana TretyakovaEvgeny BaranovSergey ShustovSergey YakushinIvan GordeevNiiaz KhasanovOlga ReshetkoTatiana SotnikovaOlga MolchanovaKonstantin NikolaevLiudmila GaponElena BaranovaZaur ShogenovElena KosmachovaYuriy KarpovAnton PovzunLiudmila EgorovaVadim TyrenkoIgor IvanovMasterov IlyaSergey KanorskyDragan SimicNikola IvanovicGoran DavidovicNebojsa TasicMilika AsaninStevo StojicSvetlana ApostolovicStevan IlicBiljana Putnikovic TosicAleksandar StankovicAleksandra ArandjelovicSlavica RadovanovicBranislava TodicJovan BalinovacDragan DincicPetar SeferovicAna KaradzicSlobodan DodicSinisa DimkovicTamara JakimovKian-Keong PohHean Yee OngJustin Tang I-ShingKarol MickoJan NociarDaniel PellaPeter FulopMarian HranaiJuraj PalkaJuraj MazurIvan MajercákAndrej DzupinaFrantišek FazekasJozef GonsorcikViliam BuganJuraj SeleckyGabriel KamenskyJaroslava StrbovaRudolf SmikAndrej DukatPeter OlexaIvan ŽuranJanez PoklukarNataša Černič ŠuligojMatija CevcHenry CysterNaresh RanjithClive CorbettJunaid BayatEllen Makoali MakotokoHendrik Du Toit TheronIlse KappMatthys de V BassonHanlie LotteringDina van AswegenLouis van ZylPeter SebastianThayabran PillayJan SaaimanPatrick CommerfordSoraya CassimjeeGarda RiazIftikhar EbrahimMahomed SarvanJoseph MynhardtHelmuth ReuterRajendran MoodleyManuel VidaAngel Cequier FillatVicente Bodí PerisFrancisco Fuentes JimenezFrancisco MarínJose Cruz FernándezRafael Jesus Hidalgo UrbanoBlas Gil-ExtremeraPablo ToledoFernando Worner DizDavid Garcia-DoradoAndres IñiguezJosé Tuñón FernándezJose Gonzalez-JuanateyJavier Fernandez PortalesFernando Civeira MurilloLaia Matas PericasJose Luis ZamoranoManuel de Mora MartinJordi Bruguera CortadaJoaquin Alonso MartinJose Maria Serrano AntolinJosé de Berrazueta FernándezJosé Antonio Vázquez de PradaJose Francisco Díaz FernándezJosé Alberto García LledóJuan Cosín SalesJavier Botas RodriguezGabriel Gusi TragantAmparo BenedictoCarlos Gonzalez-JuanateyMercedes Camprubí PotauIgnacio Plaza PerezCésar Morís de La TassaPablo Loma-Osorio RinconJavier Balaguer RecenaJuan EscudierAntonio Coca PayerasNorberto Alonso OrcajoPedro ValdivielsoGodwin ConstantineRuvaiz HaniffaNirmali TisseraStanley AmarasekeraChandrike PonnamperumaNimali FernandoKaputella FernandoJayanthimala JayawardenaSantharaj WijeyasingamGotabhaya RanasingheRuvan EkanayakaSepalika MendisVajira SenaratneGnanamoorthy MayurathanAjantha RajapakshaThilak SirisenaJagath HerathNaomali AmarasenaStefan BerglundGundars RasmanisOla VedinNils WittGeorgios MourtzinisPeter NicolOle HansenStefano RomeoSteen Agergaard JensenIngemar TorstenssonUlf AhremarkTorbjörn SundelinTiziano MoccettiFrancois MachRonald BindeOliver GämperliWei-Chuan TsaiKwo-Chang UengWen-Ter LaiMing-En LiuJuey-Jen HwangWei-Hsian YinI-Chang HsiehMing-Jer HsiehWei Hsiang LinJen-Yuan KuoTsuei-Yuan HuangChih-Yuan FangPinij KaewsuwannaWasant SoonfuangWoravut JintapakornApichard SukonthasarnNattawut WongpraparutKrisada SastravahaNakarin SansanayudhWirash KehasukcharoenDilok PiyayotaiPaiboon ChotnoparatpatAhmet CamsariHakan KultursayBulent MutluMurat ErsanliMustafa DemirtasCevat KirmaErtan UralLale KoldasOleksandr KarpenkoAlexander ProkhorovIhor VakaluykHalyna MyshanychDmytro ReshotkoValeriy BatushkinLeonid RudenkoIhor KovalskyiMykola KushnirVira TseluykoYuriy MostovoyMykola StanislavchukYulian KyiakYuriy KarpenkoYaroslav MalynovskyAndriy KlantsaOles KutniyEkaterina AmosovaViktor TashchukOleh LeshchukMykola RishkoMykola KopytsyaAndriy YagenskyMykola VatutinAndriy BagriyOlga BarnaOlexiy UshakovGeorgiy DzyakBorys GoloborodkoAnatolii RudenkoVolodymyr ZheleznyyJasper TrevelyanAzfar ZamanKaeng LeeAndrew MoriartyRajesh AggarwalPiers CliffordYuk-Ki WongSyed M.R. IqbalEduardas SubkovasDenise BraganzaDavid SarkarRobert StoreyHuw GriffithsSam McclureRangasamy MuthusamySimon SmithJohn KurianTerry LevyCraig BarrHoner KadrRobert GerberAudrius SimaitisHandrean SoranAnthony MathurAdrian BrodisonMohammad AyazMuhammad CheemaRichard OliverSimon ThackrayTelal MudawiGohar RahmanAyyaz SultanTimothy ReynoldsDavid SharmanDavid SprigingsRob ButlerPeter WilkinsonDavid FitzmauriceJulian HalcoxSean GallagherNicholas Ossei-GerningGil VardiDuccio BaldariDavid BrabhamCharles TreasureCharles DahlBruce PalmerAlan WisemanAbul KhanSanjeev PuriAnn Elizabeth MohartCarlos InceEnrique FloresScott WrightShi-Chi ChengMichael RosenbergWilliam RogersEdward KosinskiLes ForgoshJonathan WaltmanMisal KhanMohammad ShoukfehGeorges DagherPatrick CambierIra LieberPriya KumarCara EastPerry KrichmarMian HasanLindsey WhiteThomas KnickelbineThomas HaldisEve GillespieThomas AmidonDavid SuhImran ArifMouhamad AbdallahFaiq AkhterEric CarlsonMichael d'UrsoFadi El-AhdabWilliam NelsonKatie MoriartyBarry HarrisSteven CohenLuther CarterDaniel DotyKenneth SabatinoTariq HaddadAmir MalikSunder RaoAngel MulkayIon JovinKim KlanckeVinay MalhotraSai DevarapalliMichael KorenHarish ChandnaGeorge DoddsTauqir GorayaJames BengstonMatthew JanikJoseph MoranAndrew SumnerJohn KobayashiWilliam DavisShahram YazdaniJohn PasquiniMaitreya ThakkarAmarnath VedereWayne LeimbachJames RiderSarah FentonNarendra SinghAnil ShahDenise JanosikCarl PepineBrett BermanJoseph GelorminiChristopher DanielsKerensky RichardFriederike KeatingNicholas KondoSanjay ShettyHoward LeviteWinfried WaiderTheodore TakataMazen Abu-FadelVipul ShahRahul AggarwalMark IzzoAnil KumarBrack HattlerRose DoChad LinkAnna BortnickGeorge KinzfoglArnold GhitisJohn LarryEdward TeufelPeter KuhlmanBrent MclaurinWenwu ZhangStephen ThewJalal AbbasMatthew WhiteOthman IslamSumeet SubherwalNandkishore RanadiveBabak VakiliChristian GringDavid HendersonTimothy SchuchardNaim FarhatGeoffrey KlineSharan MahalJack WhitakerShawn SpeirsRolf AndersenNizar DaboulPhillip HorwitzFiras ZahrGeorge PonceZubair JafarJoseph McgarveyVipul PanchalStephen VoyceThomas BlokWilliam SheldonMasoud AzizadCarsten SchmalfussMark PiconeRobert PedersonWilliam HerzogKeith FriedmanJason LindseyRosemary NowinsEichenlaub TimothyParilak LeonardNorman LeporMahfouz El ShahawyHoward WeintraubAnand IrimpenAlvaro AlonsoWade MayDaniels ChristopherThomas GalskiAlan ChuFreny ModyEbrahimi RaminZachary HodesJoseph RossiGregory RoseJames FairlambCharles LambertAjit RaisinghaniAntonio AbbateGeorge VetrovecMarilyn KingCharles CareyJaime GerberLiwa YounisHyeun ParkMladen VidovichThomas KnutsonDennis FriedmanFred ChaleffArthur LoussararianPhillip RozemanCarey KimmelstielJeffrey KuvinKevin SilverMalcolm FosterGlen TonnessenAndrey EspinozaMohamadali AmlaniAndreas WaliChristopher MalozziGeert JongClara MasseyKeattiyoat WattanakitPhilip O'DonnellDinesh SingalNaseem JaffraniSridhar BanuruDaniel FisherMark XenakisNeal PerlmutterRavi BhagwatJames StraderRonald BlonderAyim Akyea-DjamsonAjay LabrooKwan LeeH. John MaraisEdmund ClaxtonRobert WeissRohr KathrynMartin BerkPeter RossiParag JoshiAmit KheraAjit KhairaGreg KumkumianSteven LupovitchJoshua PurowStephen WelkaDavid HoffmanStuart FischerEugene SorokaDonald EagertonSamir PancholyMichael RayNorman ErenrichMichael FarrarStewart PollockWilliam FrenchSteve DiamantisDouglas GuyLawrence GimpleMark NeustelSteven SchwartzEdward PereiraSeals AlbertDouglas SpriggsJanet StrainSuneet MittalAnthony VoMajed ChaneJason HallNampalli VijayKapildeo LotunF. Martin LesterAhed NahhasTheodore PopePaul NagerRakesh VohraMukesh SharmaRiyaz BashirHinan AhmedMichael BerlowitzRobert FishbergRobert BarruccoEric YangMichael RadinDaniel SpornDwight StapletonSteven EisenbergJoel LandzbergMartin McgoughSamir TurkMichael SchwartzP. Sandy SundramDiwakar JainMark ZaineaCarlos BayronRonald KarlsbergSuhail DohadHenry LuiWilliam KeenDonald WesterhausenSandeep KhuranaHimanshu AgarwalJessica BirchemWilliam PennyMark ChangSherrill MurphyJohn HenryBranislav Schifferdecker ;john M GilbertGopal ChalavaryaCharles EatonJohn SchmedtjeStuart ChristensonImran DotaniDouglas DenhamAlexander MacdonellJohn Paul GibsonAref RahmanTammam Al JoundiNizar AssiGary ConradPurushotham KothaMichael LoveGregory GieslerHoward RubensteinDawood GamilLaura AkrightJustine KrawczykJoanne CoblerTerry WellsJames WelkerRobert FosterRichard GilmoreJay AndersonDouglas JacobyBill HarrisGeraldine GardnerRamprasad DandillayaKishor VoraJohn KostisJohn HunterDavid LaxsonEric BallFlavia EgydioAnelise KawakamiJanaina OliveiraJulianna WozniakAlexander MatthewsCaroline RatkyJanine ValirisLisa BerdanAnita HepditchKirby QuinteroTyrus RorickMelissa WestbrookAndrea PascualCarla RovitoMadeleine BezaultElodie DrouetTabassome SimonCaroline AlsweilerAnne LuytenJulie ButtersLiddy GriffithMichelle ShawLena GrunbergShahidul IslamMarie-France BrégeaultNathalie BougonDouglas FaustinoSylvie FontecaveJudith MurphyMelanie VerrierVéronique AgnettiDorthe AndersenEmmy BadreddineMhamed BekkoucheCecile BouancheauImane BriguiMaddy BrocklehurstJoseph CianciaruloDawn DevaulSzilvia DomokosCecile GacheCaroline GobillotSeverine GuillouJan HealyMegan HeathGayatri JaiwalCarine JavierreJulien LabeirieMyriam MonierUlises MoralesAsmaa MrabtiBicky MthombeniBetim OkanLucile SmithJennifer ShellerSebastien SopenaValerie PellanFadela BenbernouNafissa BengraitMaud LamoureuxKatarina KralovaRaphael BejuitAnthony CoulangeChristelle BerthouJérôme RepincayChristelle LorenzatoAlexis EtienneValerie GouetVirginie LoizeauMickael NormandAnne OurliacChristelle RondelAntony AdamoPascale BeltranPauline BarraudHelene Dubois-GacheBenjamin HalleLamia MetwallyMaxime MourguesMarc SottyMarion VincendetRaluca CotrutaZhu ChengyueDominique Fournie-LloretChristine MorrelloAurelie PerthuisPatrick PicaultIsabelle ZobouyanHelen ColhounMichael DempseyMark Mcclanahan
• Organismes : University of Colorado [Colorado Springs] State University of New York at New Paltz University of Alabama [Birmingham] University of Toronto St. Michael's Hospital Leiden University Medical Center [Leiden] Charité - UniversitätsMedizin = Berlin University Medicine Berlin Institute of Health Universidad Autónoma de Bucaramanga Regeneron Pharmaceuticals [Tarrytown, NY] Regeneron Pharmaceuticals [Tarrytown, NY] SANOFI Recherche Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials Laboratoire de Recherche Vasculaire Translationnelle Royal Brompton Hospital [London, United Kingdom] Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans Journal of the American College of Cardiology le 26/10/2020

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Résumé : Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was <70 mg/dL (median 69.4 mg/dL; interquartile range: 64.3-74.0 mg/dL); in 14,573 patients (77.0%), both determinations were ≥70 mg/dL (median 94.0 mg/dL; interquartile range: 83.2-111.0 mg/dL). Results: In the lower LDL-C subgroup, MACE rates were 4.2 and 3.1 per 100 patient-years among placebo-treated patients with baseline lipoprotein(a) greater than or less than or equal to the median (13.7 mg/dL). Corresponding adjusted treatment hazard ratios were 0.68 (95% confidence interval [CI]: 0.52-0.90) and 1.11 (95% CI: 0.83-1.49), with treatment-lipoprotein(a) interaction on MACE (Pinteraction = 0.017). In the higher LDL-C subgroup, MACE rates were 4.7 and 3.8 per 100 patient-years among placebo-treated patients with lipoprotein(a) >13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Jean-Michel NguyenPascal JézéquelPierre GilloisLuisa SilvaFaouda Ben AzzouzSophie Lambert-LacroixPhilippe JuinMario CamponeAurélie GaultierAlexandre Moreau-GaudryDaniel Antonioli
• Organismes : Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Immunology and New Concepts in ImmunoTherapy Institut de Cancérologie de l'Ouest [Angers/Nantes] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 NANTES UNIVERSITÉ - École Centrale de Nantes Institut de Cancérologie de l'Ouest [Angers/Nantes] Université Grenoble Alpes Centre de Recherche en Cancérologie et Immunologie Nantes-Angers Institut de Cancérologie de l'Ouest [Angers/Nantes] CRLCC René Gauducheau Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Medical Informatics [Tournemire, Quartier Bellevue]
• Publié dans Bioinformatics le 25/10/2020

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Résumé : Abstract Motivation The principle of Breiman's random forest (RF) is to build and assemble complementary classification trees in a way that maximizes their variability. We propose a new type of random forest that disobeys Breiman’s principles and involves building trees with no classification errors in very large quantities. We used a new type of decision tree that uses a neuron at each node as well as an in-innovative half Christmas tree structure. With these new RFs, we developed a score, based on a family of ten new statistical information criteria, called Nguyen information criteria (NICs), to evaluate the predictive qualities of features in three dimensions. Results The first NIC allowed the Akaike information criterion to be minimized more quickly than data obtained with the Gini index when the features were introduced in a logistic regression model. The selected features based on the NICScore showed a slight advantage compared to the support vector machines—recursive feature elimination (SVM-RFE) method. We demonstrate that the inclusion of artificial neurons in tree nodes allows a large number of classifiers in the same node to be taken into account simultaneously and results in perfect trees without classification errors. Availability and implementation The methods used to build the perfect trees in this article were implemented in the ‘ROP’ R package, archived at https://cran.r-project.org/web/packages/ROP/index.html. Supplementary information Supplementary data are available at Bioinformatics online.

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Fichiers liés : btab074.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Florian Roisné-HamelinSabrina PobiegaKévin JézéquelSimona MironJordane DépagneXavier VeauteDidier BussoMarie-Hélène Le DuIsabelle CallebautJean-Baptiste CharbonnierPhilippe CuniasseSophie Zinn-JustinStéphane MarcandKeunchil ParkMustafa ÖzgüroğluJohan VansteenkisteDavid SpigelJames C.H. YangHidenobu IshiiMarina GarassinoFilippo de MarinisAleksandra SzczesnaAndreas PolychronisRuchan UsluMaciej KrzakowskiJong-Seok LeeLuana CalabròOsvaldo Arén FronteraHuiling XiongMarcis BajarsMary RuisiFabrice Barlési
• Organismes : Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie Intégrative de la Cellule Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie François JACOB Institut de Biologie Intégrative de la Cellule Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de Biologie Intégrative de la Cellule Institut de Biologie Intégrative de la Cellule Institut de Biologie Intégrative de la Cellule Institut de Biologie François JACOB Samsung Medical Center Sungkyunkwan University School of Medicine Istanbul University Cerrahpasa Department of Pulmonology Sarah Cannon Research Institute [Nashville, Tennessee] National Taiwan University Cancer Center [Taipei] IRCCS Istituto Nazionale dei Tumori [Milano] Institut de Recherche Pierre Fabre Seoul National University Bundang Hospital Azienda Ospedaliera Universitaria Senese EMD Serono Research & Development Institute EMD Serono Research & Development Institute Institut Gustave Roussy Centre de Recherche en Cancérologie de Marseille
• Publié dans Journal of Thoracic Oncology le 31/10/2020

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Résumé : Abstract Specific proteins present at telomeres ensure chromosome end stability, in large part through unknown mechanisms. In this work, we address how the Saccharomyces cerevisiae ORC-related Rif2 protein protects telomere. We show that the small N-terminal Rif2 BAT motif ( B locks A ddition of T elomeres) previously known to limit telomere elongation and Tel1 activity is also sufficient to block NHEJ and 5’ end resection. The BAT motif inhibits the ability of the Mre11-Rad50-Xrs2 complex (MRX) to capture DNA ends. It acts through a direct contact with Rad50 ATP-binding Head domains. Through genetic approaches guided by structural predictions, we identify residues at the surface of Rad50 that are essential for the interaction with Rif2 and its inhibition. Finally, a docking model predicts how BAT binding could specifically destabilise the DNA-bound state of the MRX complex. From these results, we propose that when an MRX complex approaches a telomere, the Rif2 BAT motif binds MRX Head in its ATP-bound resting state. This antagonises MRX transition to its DNA-bound state, and favours a rapid return to the ATP-bound state. Unable to stably capture the telomere end, the MRX complex cannot proceed with the subsequent steps of NHEJ, Tel1-activation and 5’ resection.

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Fichiers liés : S1556086421018323.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Julien Gomez-MartinezVincent FoulongneDidier LaureillardNicolas NagotBrigitte MontèsJean-François CantaloubePhilippe Van De PerreChantal Fournier-WirthJean-Pierre MolesJean-Charles Brès
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections Hôpital Universitaire Carémeau [Nîmes] Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Talanta le 01/11/2020

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Résumé : Human immunodeficiency virus (HIV) infection is a chronic disease that can be treated with antiretroviral (ARV) therapy. However, the success of this treatment has been jeopardized by the emergence of HIV infections resistant to ARV drugs. In low-to middle-income countries (LMICs), where transmission of resistant viruses has increased over the past decade, there is an urgent need to improve access to HIV drug resistance testing. Here, we present a proof-of-concept study of a rapid and simple molecular method to detect two major mutations (K103 N, Y181C) conferring resistance to first-line nonnucleoside reverse transcriptase inhibitor regimens. Our near-point-of-care (near-POC) diagnostic test, combining a sequence-specific primer extension and a lateral flow DNA microarray strip, allows visual detection of HIV drug resistance mutations (DRM) in a short turnaround time (4 h 30). The assay has a limit of detection of 100 copies of plasmid DNA and has a higher sensitivity than standard Sanger sequencing. The analytical performance was assessed by use of 16 plasma samples from individuals living with HIV-1 and results demonstrated the specificity and the sensitivity of this approach for multiplex detection of the two DRMs in a single test. Furthermore, this near-POC assay could be easily taylored to detect either new DRMs or DRM of from various HIV clades and might be useful for pre-therapy screening in LMICs with high levels of transmitted drug resistance.

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Fichiers liés : S003991402100299X.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Virginie CarmignacCyril MignotEmmanuelle BlanchardPaul KuentzMarie-Hélène Aubriot-LortonVictoria E.R. ParkerArthur SorlinSylvie FraitagJean-Benoît CourcetYannis DuffourdDiana RodriguezRachel KnoxSatyamaanasa PolubothuAnne BolandRobert OlasoMarc DelepineVéronique DarmencyMelissa RiachiChloé QuelinPaul RollierLouise GoujonSarah GrottoYline CapriMarie-Line JacquemontSylvie OdentDaniel AmramMartin ChevarinCatherine Vincent-DelormeBenoît CatteauLaurent GuibaudAlexis ArzimanoglouMalika KeddarCatherine SarretPatrick CallierDidier BessisDavid GenevièveJean‐françois DeleuzeChristel Thauvin-RobinetRobert SempleChristophe PhilippeJean-Baptiste RivièreVeronica KinslerLaurence FaivrePierre Vabres
• Organismes : Institut Pascal
• Publié dans Genetics in Medicine le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Brigitte Tardy-PoncetEmmanuel de MaistreClaire PouplardEmilie PreslesMartine Alhenc-GelasDominique LasneMarie‐hélène HorellouChristine MoutonAnne Serre-SapinAnne BautersPhilippe NguyenFrançois MullierJulien PerrinGrégoire Le GalPierre‐emmanuel MorangeLélia GrunebaumAgnès Lillo-Le LouetIsmail ElalamyYves GruelAndreas GreinacherThomas LecompteBernard Tardy
• Organismes : Santé Ingénierie Biologie Saint-Etienne Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
• Publié dans Journal of Thrombosis and Haemostasis le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Joris GallandBenjamin ThoreauMaxime DelrueMarie NeuwirthAlain StepanianAnthony ChauvinAzeddine DellalOlivier NalletMelanie RorizMathilde DevauxJonathan LondonGonzague Martin-LecampAntoine FroissartNouara ArabBertrand FerronMarie-Helene GroffViviane QueyrelChristine LorutLucile RegardEmilie BerthouxGuillaume BayerCloé ComarmondBertrand LiogerArsène MékinianTali-Anne SzwebelThomas SenéBlanca Amador-BoreiroOlivier ManginPierre-Olivier SellierStephane MoulyJean-Philippe KevorkianVirginie SiguretDominique VodovarDamien SèneMarie‐helene GroffTali‐anne SzwebelPierre‐olivier SellierJean‐philippe KevorkianAlbertini MathieuBouajila SaraBritany KimbimbiBurlacu RuxandraCacoub LéaChampion KarineDelcey VéroniqueDillinger Jean-GuillaumeFeron FlorineFrazier AlineThomas Funck-BretanoGauthier Diane-CecileGautier Jean-FrançoisHenry PatrickHuscenot TessaSarah IzabelMathilde JaulerryJouabli MoenesJulla Jean-BaptisteLaloi Michelin MarieLeroy PierreLopes AmandaBruno MégarbaneMichon MaximeMunier Anne-LiseNahmani YoramNicol MartinNicolas EroanPoulat AudreyRevue EricRichette PascalRiveline Jean-PierreRubenstein EmmaZanin AdrienAveneau ClémentBastard PaulBeauvais DianeBoghez LoredanaBorderiou AlixConway PaulCosma LavigniaDavy VincentDesjardin ClémentDevatine SandraDucroz Gerardin ChristelDupe CharlotteGobert ChloéGros ClotildeKadiri SoumayaKhan EnmatOngnessek SandrineRhmari FatimaSacco IsabelleSaptefrat NataliaSchaupp PaulineJustine SerreSideris GeorgiosSmati SoniaTournier MarineTreca PaulineTruong TonyTuffier MathildeArcelli MattéoBoue YvonnickCopie AlbanDeye NicolasEkherian Jean-MichelErrabih ZaccariaGonde AntoineGrant CarolineGuerin EmmanuelleMagalhaes AdèleMalissin IsabelleMeurisse EdouardMrad AymenNaim GiuliaNguyen PhilippeNitenberg KiyokoPepin‐lehalleur AdrienPerault ArthurPerrin LucileRenaud MaximeSutterlin LaetitiaDelrue MaximeSiguret VirginieStepanian Alain
• Organismes : Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans European Journal of Haematology le 22/10/2020

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Résumé : A high prevalence of pulmonary embolism (PE) has been described during COVID-19. Our aim was to identify predictive factors of PE in non-ICU hospitalized COVID-19 patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Aurélien CuchetAnthony AnchisiPhilippe TéloukYijiao YaoFrédéric SchietsFrançois FourelYohann ClémentPierre LantériElise CaréniniPatrick JameHervé Casabianca
• Organismes : ISA-PNBS - Produits naturels et biosourcés - Natural & Bio-based Products Albert Vieille SAS ISA-Isotopique & Organique - Isotopic & Organic Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement ISA-PNBS - Produits naturels et biosourcés - Natural & Bio-based Products LEHNA - Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés [équipe E3S] Chemometrics and theoretical chemistry. - Chimiométrie et chimie théorique Chemometrics and theoretical chemistry. - Chimiométrie et chimie théorique Albert Vieille SAS ISA-Isotopique & Organique - Isotopic & Organic ISA-PNBS - Produits naturels et biosourcés - Natural & Bio-based Products
• Publié dans Food Control le 24/10/2020

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Fichiers liés : S0956713521002243.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2021
• Auteurs : Dimitri LaurentChristophe DurletGuillaume BarréPatrick SorriauxPhilippe AudraPierre CartignyCédric CarpentierGuillaume ParisPauline CollonThomas RigaudierJacques PirononEric C Gaucher
• Organismes : GeoRessources Biogéosciences [UMR 6282] Centre scientifique et Technique Jean Feger Laboratoire des Fluides Complexes et leurs Réservoirs Laboratoire de Polytech Nice-Sophia Institut de Physique du Globe de Paris GeoRessources Centre de Recherches Pétrographiques et Géochimiques GeoRessources Centre de Recherches Pétrographiques et Géochimiques GeoRessources Centre scientifique et Technique Jean Feger
• Publié dans Geomorphology le 25/10/2020

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Résumé : Hypogenic caves, linked to carbonate rock dissolution due to CO 2-and H 2 S-rich ascending deep waters, represent more than 10% of karstic networks worldwide; a proportion that increases as these systems are better constrained. However, interaction between hypogenic and epigenic processes is still poorly understood, especially since the subsequent invasion of surface water often obliterates the morphological and mineral markers of hypogenic activities. The Ariège Valley (French Pyrenean foothills) hosts significant karstic networks epigenically reworked by several episodes of glacier meltwater penetration during the successive coverage of Quaternary icefields. Among these karstic systems, the Vapeur and Ermite caves were probably initiated by a hypogenic component during the Miocene. In particular, multipleS , Sr, H, C, and O isotopes of thermo-mineral waters and calcite-sulfate speleothems confirm that hydrothermal fluids reached the caves, and subsequently interacted with Quaternary glacial epigenic phases. Deep fluids conveyed CO 2 and H 2 S, both produced from the thermochemical reduction of Triassic evaporites at depth. H 2 S oxidation and CO 2 hydration in the cave atmosphere, above the water table, created sulfuric and carbonic acids responsible for an intense karstification. Interpretation of isotopic data, together with a geomorphological, mineralogical and textural study of cave minerals, allow us to propose a speleogenetic model in which the respective impact of epigenic and hypogenic processes was driven by base-level changes during successive Quaternary glacial/interglacial epochs: (i) during glacial periods, invasion of glacier meltwater within the karst led to the dilution of the hydrothermal water, and was responsible for an "epigenic mechanical-dominant" speleogenesis through water-related abrasion; (ii) interglacial epochs were marked by base-level drops and the establishment of a vadose domain in caves, favoring the widening of karstic conduits through carbonic and sulfuric acid condensation-corrosion during thermal water degassing. This "hypogenic chemical-dominant" speleogenesis was active until a new advance of glaciers, and this cycle occurred several times.

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Fichiers liés : 2021Pap_LaurentD_Geomorph_Version_Auteur.pdf

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