Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 31/07/2021
• Auteurs : Tristan GautiéJean-Philippe BouchaudPierre Le Doussal
• Organismes : Champs Aléatoires et Systèmes hors d'Équilibre Capital Fund Management Champs Aléatoires et Systèmes hors d'Équilibre
• Publié dans Journal of Physics A: Mathematical and Theoretical le 26/10/2020

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Résumé : The random variable 1 + z1 + z1z2 +. .. appears in many contexts and was shown by Kesten to exhibit a heavy tail distribution. We consider natural extensions of this variable and its associated recursion to N × N matrices either real symmetric β = 1 or complex Hermitian β = 2. In the continuum limit of this recursion, we show that the matrix distribution converges to the inverse-Wishart ensemble of random matrices. The full dynamics is solved using a mapping to N fermions in a Morse potential, which are non-interacting for β = 2. At finite N the distribution of eigenvalues exhibits heavy tails, generalizing Kesten's results in the scalar case. The density of fermions in this potential is studied for large N , and the power-law tail of the eigenvalue distribution is related to the properties of the so-called determinantal Bessel process which describes the hard edge universality of random matrices. For the discrete matrix recursion, using free probability in the large N limit, we obtain a self-consistent equation for the stationary distribution. The relation of our results to recent works of Rider and Valkó, Grabsch and Texier, as well as Ossipov, is discussed.

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Fichiers liés : Gautié et al. - 2021 - Matrix Kesten recursion, inverse-Wishart ensemble .pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/07/2021
• Auteurs : Yue JiaoFabienne LesueurChloé-Agathe AzencottMaïté LaurentNoura MebiroukLilian LabordeJuana BeauvalletMarie-Gabrielle DondonSéverine Eon-MarchaisAnthony LaugéCatherine NoguèsNadine AndrieuDominique Stoppa-LyonnetSandrine CaputoNadia Boutry-KryzaAlain CalenderSophie GiraudMélanie LéoneBrigitte Bressac-de PailleretsOlivier CaronMarine Guillaud-BatailleYves-Jean BignonNancy UhrhammerValérie BonadonaChristine LassetPascaline BerthetLaurent CastéraDominique VaurViolaine BourdonTestsuro NoguchiCornel PopoviciAudrey RemenierasHagay SobolIsabelle CoupierPierre-Olivier HarmandPascal PujolPaul VilquinAurélie DumontFrançoise RévillionDanièle MullerEmmanuelle Barouk-SimonetFrançoise BonnetVirginie BubienMichel LongyNicolas SévenetLaurence GladieffRosine GuimbaudViviane FeillelChristine ToulasHélène DreyfusDominique LerouxMagalie PeysselonChristine RebischungAmandine BaurandGeoffrey BertoloneFanny CoronLaurence FaivreVincent GoussotCaroline JacquotCaroline SawkaCaroline KientzMarine LebrunFabienne PrieurSandra Fert-FerrerVéronique MariLaurence Venat BouvetStéphane BézieauCapucine DelnatteIsabelle MortemousqueFlorence CouletFlorent SoubrierMathilde WarcoinMyriam BronnerSarab LizardJohanna SokolowskaMarie-Agnès Collonge-RameAlexandre DamettePaul GestaHakima LallaouiJean ChiesaDenise Molina-GomesOlivier IngsterSylvie Manouvrier-HanuSophie LejeunePauline PontoisDominique Stoppa LyonnetMarion Gauthier-VillarsBruno BuecherEmmanuelle Mouret-FourmeJean-Pierre FrickerElisabeth LuporsiMarc FrénayFrançois EisingerJessica MorettaCatherine DugastChrystelle ColasAlain LortholaryPhilippe VenninClaude AdenisTan Dat NguyenAnnick RossiJulie TinatIsabelle TennevetJean-Marc LimacherChristine MaugardJean-Yves BignonLiliane DemangeOdile Cohen-HaguenauerBrigitte Gilbert-DussardierHélène Zattara-Cannoni
• Organismes : Institut Curie [Paris] Université Paris Sciences et Lettres Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Institut Curie [Paris] Université Paris Sciences et Lettres Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Université Paris Sciences et Lettres Centre de Bioinformatique Institut Curie [Paris] Université Paris Sciences et Lettres Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Institut Curie [Paris] Université Paris Sciences et Lettres Institut Paoli-Calmettes Unité de génétique et biologie des cancers Université Paris Descartes - Paris 5 Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Institut Curie [Paris] Université Paris Sciences et Lettres Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Institut Curie [Paris] Université Paris Sciences et Lettres Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Institut Curie [Paris] Université Paris Sciences et Lettres Institut Curie [Paris] Université Paris Sciences et Lettres Institut Paoli-Calmettes Unité de génétique et biologie des cancers Université Paris Descartes - Paris 5 Aix Marseille Université Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Institut Curie [Paris] Université Paris Sciences et Lettres Institut Curie [Paris] Université Paris Sciences et Lettres Université Paris Cité Unité de génétique et biologie des cancers Institut Curie [Paris] Université Paris Sciences et Lettres Centre Hospitalier Régional Universitaire [Montpellier] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
• Publié dans BMC Medical Research Methodology le 01/11/2020

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Résumé : Background: Linking independent sources of data describing the same individuals enable innovative epidemiological and health studies but require a robust record linkage approach. We describe a hybrid record linkage process to link databases from two independent ongoing French national studies, GEMO (Genetic Modifiers of BRCA1 and BRCA2), which focuses on the identification of genetic factors modifying cancer risk of BRCA1 and BRCA2 mutation carriers, and GENEPSO (prospective cohort of BRCAx mutation carriers), which focuses on environmental and lifestyle risk factors. Methods: To identify as many as possible of the individuals participating in the two studies but not registered by a shared identifier, we combined probabilistic record linkage (PRL) and supervised machine learning (ML). This approach (named "PRL + ML") combined together the candidate matches identified by both approaches. We built the ML model using the gold standard on a first version of the two databases as a training dataset. This gold standard was obtained from PRL-derived matches verified by an exhaustive manual review. Results The Random Forest (RF) algorithm showed a highest recall (0.985) among six widely used ML algorithms: RF, Bagged trees, AdaBoost, Support Vector Machine, Neural Network. Therefore, RF was selected to build the ML model since our goal was to identify the maximum number of true matches. Our combined linkage PRL + ML showed a higher recall (range 0.988-0.992) than either PRL (range 0.916-0.991) or ML (0.981) alone. It identified 1995 individuals participating in both GEMO (6375 participants) and GENEPSO (4925 participants). Conclusions: Our hybrid linkage process represents an efficient tool for linking GEMO and GENEPSO. It may be generalizable to other epidemiological studies involving other databases and registries.

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Fichiers liés : s12874-021-01299-6.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/07/2021
• Auteurs : Maxime DevogèleMarin FerraisEmmanuël JehinNicholas A MoskovitzBrian SkiffStephen LevineAnnika GustafssonDavide FarnocchiaMarco MicheliColin SnodgrassGalin BorisovJ. ManfroidYoussef MoulaneZouhair BenkhaldounArtem BurdanovFrancisco PozuelosMichael GillonJulien De witSimon GreenPhilippe BendjoyaJean-Pierre RivetLuy AbeDavid VernetColin Orion ChandlerChadwick Trujillo
• Organismes : Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Space Sciences, Technologies and Astrophysics Research Institute Lowell Observatory [Flagstaff] Jet Propulsion Laboratory SUPA School of Physics and Astronomy [Edinburgh] Joseph Louis LAGRANGE
• Publié dans Monthly Notices of the Royal Astronomical Society le 30/10/2020

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Résumé : ABSTRACT In 2018 December, the main-belt asteroid (6478) Gault was reported to display activity. Gault is an asteroid belonging to the Phocaea dynamical family and was not previously known to be active, nor was any other member of the Phocaea family. In this work, we present the results of photometric and spectroscopic observations that commenced soon after the discovery of activity. We obtained observations over two apparitions to monitor its activity, rotation period, composition, and possible non-gravitational orbital evolution. We find that Gault has a rotation period of P = 2.4929 ± 0.0003 h with a light-curve amplitude of 0.06 magnitude. This short rotation period close to the spin barrier limit is consistent with Gault having a density no smaller than ρ = 1.85 g cm−3 and its activity being triggered by the YORP (Yarkovsky–O’Keefe–Radzievskii–Paddack) spin-up mechanism. Analysis of the Gault phase curve over phase angles ranging from 0.4° to 23.6° provides an absolute magnitude of H = 14.81 ± 0.04, G1 = 0.25 ± 0.07, and G2 = 0.38 ± 0.04. Model fits to the phase curve find the surface regolith grain size constrained between 100 and 500 $\rm {\mu }$m. Using relations between the phase curve and albedo, we determine that the geometrical albedo of Gault is pv = 0.26 ± 0.05 corresponding to an equivalent diameter of $D = 2.8^{+0.4}_{-0.2}$ km. Our spectroscopic observations are all consistent with an ordinary chondrite-like composition (S, or Q-type in the Bus-DeMeo taxonomic classification). A search through archival photographic plate surveys found previously unidentified detections of Gault dating back to 1957 and 1958. Only the latter had been digitized, which we measured to nearly double the observation arc of Gault. Finally, we did not find any signal of activity during the 2020 apparition or non-gravitational effects on its orbit.

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Fichiers liés : 2021_DFJMetal2021a_MNRAS_Gault_ArXiV (1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2021
• Auteurs : Liheng YinAlexandra ZahradnikovaRiccardo RizzettoSimona BoncompagniCamille Rabesahala de MeritensYadan ZhangPierre JoanneElena Marqués-SuléYuriana Aguilar- SánchezMiguel Fernández-TenorioOlivier VillejoubertLinwei LiYue Yi WangPhilippe MatéoValérie NicolasPascale GerbaudF. Anthony Anthony LaiRomain PerrierJosefina Ramos-FrancoErnst NiggliHéctor H ValdiviaCarmen R ValdiviaJosefina Ramos-FrancoEsther ZorioSpyros ZissimopoulosFeliciano ProtasiJean-Pierre BenitahAna Maria Gómez
• Organismes : Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara] Institute of Life Science [Swansea] Institute of Life Science [Swansea] Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Rush University Medical Center [Chicago] Universität Bern = University of Bern = Université de Berne Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Ingénierie et Plateformes au Service de l'Innovation Thérapeutique Signalisation et physiopathologie cardiovasculaire Qatar University Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Universität Bern = University of Bern = Université de Berne University of Wisconsin-Madison University of Wisconsin-Madison Rush University Medical Center [Chicago] Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares Institute of Life Science [Swansea] Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara] Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire
• Publié dans Circulation Research le 29/10/2020

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Résumé : Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2R420Q. Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in knock-in mouse cardiomyocytes and by microelectrodes in mutant human induced pluripotent stem cell-derived cardiomyocytes), we observed an increased occurrence of delayed afterdepolarizations under isoproterenol stimulation, associated with increased Ca2+ waves during confocal Ca2+ recording in both mouse and human RyR2R420Q cardiomyocytes. In addition, Ca2+-induced Ca2+-release, as well as a rough indicator of fractional Ca2+ release, were higher and Ca2+ sparks longer in the RyR2R420Q-expressing cells. At the ultrastructural nanodomain level, we observed smaller RyR2 clusters and widened junctional sarcoplasmic reticulum measured by gated stimulated emission depletion super-resolution and electron microscopy, respectively. The increase in junctional sarcoplasmic reticulum width might be due to the impairment of RyR2R420Q binding to JPH2 (junctophilin-2), as there were less junctophilin-2 coimmunoprecipitated with RyR2R420Q. At the single current level, the RyR2R420Q channel dwells longer in the open state at low intracellular Ca2+ ([Ca2+]i), but there is predominance of a subconductance state. The latter might be correlated with an enhanced interaction between the N terminus and the core solenoid, a RyR2 interdomain association that has not been previously implicated in the pathogenesis of arrhythmias and sudden cardiac death. Conclusions: The RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation modifies the interdomain interaction of the channel and weakens its association with JPH2. These defects may underlie both nanoscale disarrangement of the dyad and channel dysfunction.

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Fichiers liés : yin et al. - Impaired Binding to Junctophilin2 and Nanostructur.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2021
• Auteurs : Jean-Yves SalleAchille TchallaRemy ThirionAnnick OffretLaurence DussaulxFlorence TrivinCaroline GayotPhilippe FayemendyPierre JésusCécile BonhommeEtienne HazartCharlotte BaudryJean-Claude Desport
• Organismes : Service de Médecine Physique et Réadaptation Handicap, Activité, Vieillissement, Autonomie, Environnement Service de Médecine Gériatrique [CHU Limoges] Centre hospitalier Rene Pleven de Dinan CH de Saint-Malo [Broussais] Clinique Saint-Yves [Rennes] Clinique Saint-Yves [Rennes] Handicap, Activité, Vieillissement, Autonomie, Environnement Service de Médecine Gériatrique [CHU Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Lactalis Nutrition Santé LACTALIS RECHERCHE ET DEVELOPPEMENT LACTALIS RECHERCHE ET DEVELOPPEMENT Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges]
• Publié dans SN Comprehensive Clinical Medicine le 30/11/2020

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Résumé : Abstract Management of oropharyngeal dysphagia (OD) is mainly based on modifying liquid viscosity and solid consistency in order to preserve oral feeding while avoiding unsafe swallowing. Adding thickening powders (TP) to water is the most common practice in patients suffering from OD to liquids, but ready-to-use gelled waters (RGW) can also be proposed. The main objective of this study was to assess the efficacy of a RGW and a TP on swallowing in hospitalized patients with different OD etiologies. This open, crossover, multicenter trial recruited thirty hospitalized patients with OD to liquids, confirmed by positive 3-ounce water test or positive Practical Aspiration Screening Scheme test. The patient’s ability to swallow 120 g of a RGW (IDDSI level 4) and a drink prepared with TP (nectar viscosity; NTP, 291 cP, IDDSI level 2; or if necessary, honey; HTP, 769 cP, IDDSI level 3) was evaluated in a random order at 1- to 3-day intervals. The main criterion was the efficacy of each product, defined as the proportion of patients who successfully swallowed without immediate reflexive cough. The RGW and TP were successfully swallowed in respectively 93.3% (95% CI: 77.9–99.2) and 82.8% (95% CI: 64.2–94.2) of patients with different dysphagia etiologies (stroke, neurodegenerative diseases, or aging) and unable to swallow thin water. Taste and texture of both study products were well appreciated by patients, with a preference for the RGW over TP. Therefore, the use of these thickened products could be part of the therapeutic strategy for patients with OD to liquids.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 22/07/2021
• Auteurs : Constance DouwesPhilippe EslingJean-Pierre Briot
• Organismes : Sciences et Technologies de la Musique et du Son Sciences et Technologies de la Musique et du Son Systèmes Multi-Agents

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Résumé : In recent years, the deep learning community has largely focused on the accuracy of deep generative models, resulting in impressive improvements in several research fields. However, this scientific race for quality comes at a tremendous computational cost, which incurs vast energy consumption and greenhouse gas emissions. If the current exponential growth of computational consumption persists, Artificial Intelligence (AI) will sadly become a considerable contributor to global warming. At the heart of this problem are the measures that we use as a scientific community to evaluate our work. Currently, researchers in the field of AI judge scientific works mostly based on the improvement in accuracy, log-likelihood, reconstruction or opinion scores, all of which entirely obliterates the actual computational cost of generative models. In this paper, we introduce the idea of relying on a multi-objective measure based on Pareto optimality, which simultaneously integrates the models accuracy, as well as the environmental impact of their training. By applying this measure on the current state-of-the-art in generative audio models, we show that this measure drastically changes the perceived significance of the results in the field, encouraging optimal training techniques and resource allocation. We hope that this type of measure will be widely adopted, in order to help the community to better evaluate the significance of their work, while bringing computational cost-and in fine carbon emissions-in the spotlight of AI research.

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Fichiers liés : 2107.02621.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/07/2021
• Auteurs : Thomas BarbaEmmanuel BachyAlizée MaarekGaëlle FossardLaurent GenestierDany AnglicheauValérie MoalJacques DantalPhilippe RieuJonathan ChemounyManon CharrierAntoine DurrbachFrançois ProvotDidier DuclouxPierre-François WesteelAnne-Elisabeth HengJean-Philippe RerolleBenoît BarrouPhilippe GrimbertValérie ChateletChristiane MoussonBénédicte JanbonVincent PerninLuc FrimatNacera OualiDenis GlotzAntoine ThierryChristophe MariatMathias BüchlerPhilippe GaulardVéronique LeblondEmmanuel MorelonValérie DuboisGilles SallesSophie CaillardOlivier Thaunat
• Organismes : Centre International de Recherche en Infectiologie Hôpital Edouard Herriot [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Lyon Sud [CHU - HCL] Université Claude Bernard Lyon 1 Immuno-Biologie des Lymphomes [CIRI] Hôpital Henri Mondor Centre Hospitalier Lyon Sud [CHU - HCL] Université Claude Bernard Lyon 1 Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon Immuno-Biologie des Lymphomes [CIRI] Institut Necker Enfants-Malades Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire d'Angers Réseau CENTAURE Centre de Recherche en Transplantation et Immunologie Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Ethologie animale et humaine Immunologie intégrative des tumeurs et immunothérapie des cancers Service de Néphrologie et Transplantation rénale [CHRU-lille] Centre Hospitalier Régional Universitaire de Besançon CHU Amiens-Picardie CHU Gabriel Montpied [Clermont-Ferrand] Unité de Nutrition Humaine Université de Limoges CHU Pitié-Salpêtrière [AP-HP] CHU Henri Mondor [Créteil] Centre Universitaire des Maladies Rénales [CHU Caen] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Hospitalier Universitaire [Strasbourg] CHU Dijon Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [Strasbourg] CHU Montpelier Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Nancy Centre Hospitalier Universitaire [Strasbourg] Assistance publique - Hôpitaux de Paris (AP-HP) Centre Hospitalier Universitaire [Strasbourg] Assistance publique - Hôpitaux de Paris (AP-HP) Centre Hospitalier Universitaire [Strasbourg] Département de Néphrologie [CHU Poitiers] Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire [Strasbourg] CHU Trousseau [Tours] Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Center for Interdisciplinary Research and Innovation Hôpital Edouard Herriot [CHU - HCL] EFS Hospices Civils de Lyon Immuno-Biologie des Lymphomes [CIRI] Centre Hospitalier Universitaire [Strasbourg] Center for Interdisciplinary Research and Innovation Hospices Civils de Lyon Centre International de Recherche en Infectiologie Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI] Service de transplantation, néphrologie et immunologie clinique Service de transplantation Service de Transplantation, Néphrologie et Immunologie Clinique [Lyon] Service de Transplantation, Néphrologie et Immunologie Clinique [Hôpital Edouard Herriot, HCL] Lyon Immunopathology Federation
• Publié dans Transplantation le 25/10/2020

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Résumé : Background. Posttransplant lymphoproliferative disorders (PTLDs) encompass a spectrum of heterogeneous entities. Because the vast majority of cases PTLD arise from B cells, available data on PTLD of T or NK phenotype (T/NK-cell PTLD) are scarce, which limits the quality of the management of these patients. Methods. All adult cases of PTLD diagnosed in France were prospectively recorded in the national registry between 1998 and 2007. Crosschecking the registry data with 2 other independent national databases identified 58 cases of T/NK-cell PTLD. This cohort was then compared with (i) the 395 cases of B-cell PTLD from the registry, and of (ii) a cohort of 148 T/NK-cell lymphomas diagnosed in nontransplanted patients. Results. T/NK-cell PTLD occurred significantly later after transplantation and had a worse overall survival than B-cell PTLD. Two subtypes of T/NK-cell PTLD were distinguished: (i) cutaneous (28%) and (ii) systemic (72%), the latter being associated with a worse prognosis. Compared with T/NK-cell lymphomas of nontransplanted patients, overall survival of systemic T/NK-cell PTLD was worse (hazard ratio: 2.64 [1.76-3.94]; P < 0.00001). Conclusions. This difference, which persisted after adjustment on tumoral mass, histological subtype, and extension of the disease at diagnosis could be explained by the fact that transplanted patients were less intensively treated and responded less to chemotherapy.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2021
• Auteurs : Floriane GibaultManon SturbautMathilde CoevoetMartine PugnièreAshley BurtscherFrédéric AllemandPatricia MelnykWanjin HongBrian RubinAjaybabu PobbatiJean-François GuichouPhilippe CotelleFabrice Bailly
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Institut de Recherche en Cancérologie de Montpellier Centre de Biochimie Structurale [Montpellier] Lille Neurosciences & Cognition - U 1172 Agency for science, technology and research [Singapore] ‎ National Heart Centre Singapore Departments of Pathology and Cancer Biology [Cleveland, OH, USA] Université de Lille Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172
• Publié dans ChemMedChem le 29/10/2020

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Résumé : Abstract Starting from our previously reported hit, a series of 1,5‐diaryl‐1,2,3‐triazole‐4‐carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ‐TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetry, and some of the compounds were also found to moderately disrupt the YAP‐TEAD interaction, as assessed by a fluorescence polarization assay. A TEAD luciferase gene reporter assay performed in HEK293T cells and RTqPCR measurements in MDA‐MB231 cells showed that these compounds inhibit YAP/TAZ‐TEAD activity to cells in the micromolar range. In spite of the cytotoxic effects displayed by some of the compounds of this series, they are still good starting points and can be suitably modified into an effective and viable YAP‐TEAD disruptor in the future.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2021
• Auteurs : Laurent MarivauxJorge Vélez-JuarbeLázaro W Viñola LópezPierre-Henri FabreFrançois PujosHernán Santos- MercadoEduardo J CruzAlexandra M Grajales PérezJames PadillaKevin I Vélez-RosadoJean-Jacques CorneeMélody PhilipponPhilippe MunchPierre-Olivier Antoine
• Organismes : Institut des Sciences de l'Evolution de Montpellier Natural History Museum of Los Angeles County University of Florida [Gainesville] Institut des Sciences de l'Evolution de Montpellier Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales [Mendoza] University of Puerto Rico at Mayagüez University of Puerto Rico at Mayagüez University of Puerto Rico at Mayagüez University of Puerto Rico at Mayagüez Université du Michigan = University of Michigan [Ann Arbor] Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Institut des Sciences de l'Evolution de Montpellier
• Publié dans Papers in Palaeontology le 04/03/2016

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Résumé : The West Indies are a natural laboratory for the study of biogeography and evolution, especially for mammals. The modality of their arrival in the Caribbean islands is a highly controversial issue, and palaeontological evidence remains particularly elusive. Lower Oligocene deposits of Puerto Rico (c. 29.5 Ma) have recently yielded the oldest archipelago rodents, with teeth of two chinchilloid caviomorphs of South American origin. Here we report the discovery of additional dental remains from the same level, testifying to the occurrence of another rodent group. Their morphology is singular but otherwise characteristic of North/Central American geomyin geomorphs (including extant kangaroo rats, pocket mice, and pocket gophers), and leads us to propose here a new taxon: Caribeomys merzeraudi gen. et sp. nov. The evidence of geomorphs in the West Indies challenges the view that all extinct and extant Antillean rodents derived from South American sources. The morphological singularity of this Puerto Rican geomorph also suggests an early split of this insular lineage from coeval mainland counterparts, and its dispersal towards the West Indies sometime around the Eocene–Oligocene transition. This unexpected rodent adds to the few cases of Antillean terrestrial vertebrates of North American origins, such as solenodonotan eulipotyphlans. In the absence of subaerial land connections between both landmasses, an overwater dispersal may explain mid-Palaeogene colonization of the West Indies by geomorph rodents.

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Fichiers liés : Marivaux-et-al-2021-Papers-in-Palaeontology_Geomorpha-Oligo-Puerto-Rico.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2021
• Auteurs : Aparna BhattacharyaDavid BennettJean-Philippe BeaulieuIan BondNaoki KoshimotoJessica LuJoshua BlackmanAikaterini VandorouSean TerryVirginie BatistaJean Baptiste MarquetteAndrew ColeAkihiko FukuiCalen Henderson‪clément Ranc
• Organismes : NASA Goddard Space Flight Center Aston Business School The University of Tokyo University of Tasmania [Hobart] Institut d'Astrophysique de Paris
• Publié dans The Astronomical Journal le 22/10/2020

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Fichiers liés : Bhattacharya_2021_AJ_162_60.pdf

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