Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2021
• Auteurs : Nagham KhanaferPhilippe VanhemsSabrina BenniaGéraldine Martin-GaujardLaurent JuillardThomas RimmeléLaurent ArgaudOlivier MartinLaetitia HuriauxGuillaume MarcotteRomain HernuBernard FloccardPierre CassierStudy Group
• Organismes : Fondation Mérieux Centre International de Recherche en Infectiologie Hôpital Edouard Herriot [CHU - HCL] ESCMID Study Group for Clostridioides Difficile (ESGCD) Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hôpital Edouard Herriot [CHU - HCL] Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hôpital Edouard Herriot [CHU - HCL] Université Claude Bernard Lyon 1 Cardiovasculaire, métabolisme, diabétologie et nutrition Service de Néphrologie Hospices Civils - hta - dialyse Hôpital Edouard Herriot [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition Hôpital Edouard Herriot [CHU - HCL] Centre de recherche sur les liens sociaux Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse Hôpital Edouard Herriot [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL]
• Publié dans International Journal of Environmental Research and Public Health le 01/11/2020

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Résumé : Introduction: Clostridioides (Clostridium) difficile can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. C. difficile, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from C. difficile infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by C. difficile and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for C. difficile testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2021
• Auteurs : Taeoh KwonHideaki ShibataSebastian Kepfer-RojasInger SchmidtKlaus LarsenClaus BeierBjörn BergKris VerheyenJean-Francois LamarqueFrank HagedornNico EisenhauerIka DjukicKappel Schmidt IngerSteenberg Larsen KlausFrancois Lamarque JeanAdriano CalimanAlain PaquetteAlba Gutiérrez-GirónAlessandro PetragliaAlgirdas AugustaitisAmélie SaillardCarolina Ruiz-Fernández AnaI. Sousa AnaI. Lillebø AnaRocha Gripp Anderson DaAndrea LamprechtAndreas BohnerAndré-Jean FrancezAndrey MalyshevAndrijana AndrićAngela StanisciAnita ZollesAnna AvilaAnna-Maria VirkkalaAnne ProbstAnnie OuinA. Khuroo AnzarArne VerstraetenArtur StefanskiAurora GaxiolaBart MuysBeatriz GozaloBernd AhrendsBo YangBrigitta ErschbamerRodríguez Ortíz Carmen EugeniaT. Christiansen CasperCéline MeredieuCendrine MonyCharles NockChiao-Ping WangChristel BaumChristian RixenChristine DelireChristophe PiscartChristopher AndrewsCorinna RebmannCristina BranquinhoDick JanDirk WundramDušanka VujanovićCarol Adair E.Eduardo Ordóñez-RegilR. Crawford EdwardF. Tropina ElenaElisabeth HornungElli GronerÉric LucotEsperança GaciaEsther LévesqueEvanilde BeneditoA. Davydov EvgenyPadilha Bolzan FábioT. Maestre FernandoFlorence Maunoury-DangerFlorian KitzFlorian HofhanslFlurin SutterAlmeida Lobo Francisco DeLeadro Souza FrancoFranz ZehetnerKouamé Koffi FulgenceGeorg WohlfahrtGiacomo CertiniDaiane Pinha GiseleGrizelle GonzálezGuylaine CanutHarald PauliA. Bahamonde HéctorHeike FeldhaarHeinke JägerCristina Serrano HelenaHélène VerheydenHelge BruelheideHenning MeesenburgHermann JungkunstHervé JactelHiroko KurokawaIan YesilonisInara MeleceVan Halder IngeGarcía Quirós InmaculadaIstván FeketeIvika OstonenJana BorovskáJavier RoalesHasan Shoqeir JawadJean-Christophe LataJean-Luc ProbstJeyanny VijayanathanJiri DolezalJoan-Albert Sanchez-CabezaJoël MerletJohn LoehrVon Oppen JonathanJörg LöfflerBenito Alonso José LuisJosé-Gilberto Cardoso-MohedanoJosep PenuelasC. Morina JosephDarío Quinde JuanJ. Jiménez JuanM. Alatalo JuhaJulia SeeberJulia KemppinenJutta StadlerKaie KriiskaKarel van den MeerscheKaribu FukuzawaKatalin SzlaveczKatalin JuhosKatarína GerhátováKate LajthaKatie JenningsKatja TielbörgerKazuhiko HoshizakiKen GreenKlaus SteinbauerLaryssa PazianotoLaura DienstbachLaura YahdjianJ. Williams LauraLaurel BrighamLee HannaDen Brink Liesbeth VanLindsey RustadLourdes MorillasSilva Carneiro LucianaDi Martino LucianoLuis VillarFernandes Tavares Luísa AlícidaMadison MorleyManuela WinklerMarc LebouvierMarcello TomaselliMarcus SchaubMaria GlushkovaAlmazan Torres Maria GuadalupeDe Graaff Marie-AnneMarie-Noëlle PonsMarijn BautersMarina MazónMark FrenzelMarkus WagnerMarkus DidionMaroof HamidMarta LopesMartha AppleMartin WeihMatej MojsesMatteo GualminiMatthew VadeboncoeurMichael BierbaumerMichael DangerMichael Scherer-LorenzenMichal RůžekMichel IsabellonDi Musciano MicheleMichele CarbognaniMiglena ZhiyanskiMihai PuşcaşMilan BarnaMioko AtakaMiska LuotoH. Alsafaran MohammedNadia BarsoumNaoko TokuchiNathalie KorboulewskyNicolas LecomteNina FilippovaNorbert HölzelOlga FerlianOscar RomeroOsvaldo Pinto-JrPablo PeriDan Turtureanu PavelPeter HaasePeter MacreadieB. Reich PeterPetr PetříkPhilippe CholerPierre MarmonierQuentin PonetteDettogni Guariento RafaelRafaella CanessaRalf KieseRebecca HewittRobert WeigelRóbert KankaCazzolla Gatti RobertoLemes Martins RodrigoRomà OgayaRomain GeorgesG. Gavilán RosarioSally WittlingerSara PuijalonSatoshi SuzukiSchädler MartinSchmidt AnjaSébastien GogoSilvio SchuelerSimon DrollingerSimone MereuSonja WipfStacey Trevathan-TackettStefan StollStefan LöfgrenStefan TrogischSteffen SeitzStephan GlatzelSusanna VennSylvie DoussetTaiki MoriTakanori SatoTakuo HishiTatsuro NakajiTheurillat Jean-PaulThierry CambouliveThomas SpiegelbergerThomas ScholtenJ. Mozdzer ThomasTill KleinebeckerTomáš RusňákTshililo RamaswielaTsutom HiuraTsutomu EnokiTudor-Mihai UrsuDi Cella Umberto MorraUte HamerValentin KlausDi Cecco ValterVanessa RegoVeronika FontanaVeronika PiscováVincent BretagnolleVincent MaireVinicius FarjallaVittoz PascalWenjun ZhouWentao LuoWilliam ParkerYasuhiro UtsumiYuji KominamiZsolt KotroczóZsolt TóthHélène Verheyden
• Organismes : Field Science Center for Northern Biosphere Field Science Center for Northern Biosphere Department of Geosciences and Natural Resource Management [Copenhagen] Department of Geosciences and Natural Resource Management [Copenhagen] Department of Geosciences and Natural Resource Management [Copenhagen] Department of Geosciences and Natural Resource Management [Copenhagen] Department of Forest Sciences [Helsinki] Department of Forest and Water Management, Forest & Nature Lab National Center for Atmospheric Research [Boulder] Swiss Federal Institute for Forest, Snow and Landscape Research WSL German Centre for Integrative Biodiversity Research Leipzig University / Universität Leipzig Swiss Federal Institute for Forest, Snow and Landscape Research WSL Ecosystèmes, biodiversité, évolution [Rennes] Zone Atelier du Bassin de la Moselle Laboratoire Ecologie Fonctionnelle et Environnement Ecosystèmes, biodiversité, évolution [Rennes] Unité de recherche Comportement et Ecologie de la Faune Sauvage Ecosystèmes forestiers LEHNA - Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés [équipe E3S] Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés LEHNA - Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés [équipe EVZH] Unité de recherche Comportement et Ecologie de la Faune Sauvage
• Publié dans Frontiers in Forests and Global Change le 09/04/2020

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Résumé : Litter decomposition is a key process for carbon and nutrient cycling in terrestrial ecosystems and is mainly controlled by environmental conditions, substrate quantity and quality as well as microbial community abundance and composition. In particular, the effects of climate and atmospheric nitrogen (N) deposition on litter decomposition and its temporal dynamics are of significant importance, since their effects might change over the course of the decomposition process. Within the TeaComposition initiative, we incubated Green and Rooibos teas at 524 sites across nine biomes. We assessed how macroclimate and atmospheric inorganic N deposition under current and predicted scenarios (RCP 2.6, RCP 8.5) might affect litter mass loss measured after 3 and 12 months. Our study shows that the early to mid-term mass loss at the global scale was affected predominantly by litter quality (explaining 73% and 62% of the total variance after 3 and 12 months, respectively) followed by climate and N deposition. The effects of climate were not litter-specific and became increasingly significant as decomposition progressed, with MAP explaining 2% and MAT 4% of the variation after 12 months of incubation. The effect of N deposition was litter-specific, and significant only for 12-month decomposition of Rooibos tea at the global scale. However, in the temperate biome where atmospheric N deposition rates are relatively high, the 12-month mass loss of Green and Rooibos teas decreased significantly with increasing N deposition, explaining 9.5% and 1.1% of the variance, respectively. The expected changes in macroclimate and N deposition at the global scale by the end of this century are estimated to increase the 12-month mass loss of easily decomposable litter by 1.1– 3.5% and of the more stable substrates by 3.8–10.6%, relative to current mass loss. In contrast, expected changes in atmospheric N deposition will decrease the mid-term mass loss of high-quality litter by 1.4–2.2% and that of low-quality litter by 0.9–1.5% in the temperate biome. Our results suggest that projected increases in N deposition may have the capacity to dampen the climate-driven increases in litter decomposition depending on the biome and decomposition stage of substrate.

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Fichiers liés : Kwon_28151.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2021
• Auteurs : Ziqi ZhouPaul MarconXavier DevauxPhilippe PigeatAlexandre BouchéSylvie MigotAbdallah JaafarRémi ArrasMichel VergnatLei RenHans TornatzkyCédric RobertXavier MarieJean-Marie GeorgeHenri-Yves JaffrèsMathieu StoffelHervé RinnertZhongming WeiPierre RenucciLionel CalmelsYuan Lu
• Organismes : Institut Jean Lamour University of Chinese Academy of Sciences [Beijing] Matériaux et dispositifs pour l'Electronique et le Magnétisme Institut Jean Lamour Institut Jean Lamour Institut Jean Lamour Institut Jean Lamour Institut Jean Lamour Matériaux et dispositifs pour l'Electronique et le Magnétisme Institut Jean Lamour Laboratoire de physique et chimie des nano-objets Laboratoire de physique et chimie des nano-objets Laboratoire de physique et chimie des nano-objets Laboratoire de physique et chimie des nano-objets Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Institut Jean Lamour Institut Jean Lamour University of Chinese Academy of Sciences [Beijing] Laboratoire de physique et chimie des nano-objets Matériaux et dispositifs pour l'Electronique et le Magnétisme Institut Jean Lamour
• Publié dans ACS Applied Materials & Interfaces le 01/11/2020

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Résumé : Perpendicularly magnetized spin injector with high Curie temperature is a prerequisite for developing spin optoelectronic devices on 2D materials working at room temperature (RT) with zero applied magnetic field. Here, we report the growth of Ta/CoFeB/MgO structures with a large perpendicular magnetic anisotropy (PMA) on full coverage monolayer (ML) MoS2. A large perpendicular interface anisotropy energy of 0.975mJ/m 2 has been obtained at the CoFeB/MgO interface, comparable to that observed in magnetic tunnel junction systems. It is found that the insertion of MgO between the ferromagnetic metal (FM) and the 2D material can effectively prevent the diffusion of the FM atoms into the 2D material. Moreover, the MoS2 ML favors a MgO(001) texture and plays a critical role to establish the large PMA. First principle calculations on a similar Fe/MgO/MoS2 structure reveal that the MgO thickness can modify the MoS2 band structure, from an indirect bandgap with 7ML-MgO to a direct bandgap with 3ML-MgO. Proximity effect induced by Fe results in a splitting of 10meV in the valence band at the Γ point for the 3ML-MgO structure while it is negligible for the 7ML-MgO structure. These results pave the way to develop RT spin optoelectronic devices on 2D transition-metal dichalcogenide materials.

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Fichiers liés : PMA CoFeB on full coverage monolayer MoS2-ACS AMI revised-for arxiv.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 14/07/2021
• Auteurs : Jean David Lau Hiu HoongJérôme LuxPierre-Yves MahieuxPhilippe TurcryAbdelkarim Aït-Mokhtar
• Organismes : Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2021
• Auteurs : Marc KermorgantAyria SadeghThomas GeeraertsFanny VarenneJérémy LibertoFrançois-Philippe RoubelatNoémie BatailleMarie-Pierre BareilleArnaud BeckBrigitte GodardAdrianos GolemisNathalie NasrD. N. ArvanitisOphélie HélissenJean-Michel SenardAnne Pavy-Le TraonVincent Soler
• Organismes : Institut des Maladies Métaboliques et Cardiovasculaires Service d'Ophtalmologie [CHU Toulouse] Pôle Anesthésie Réanimation [CHU de Toulouse] Service d'Ophtalmologie [CHU Toulouse] Service d'Ophtalmologie [CHU Toulouse] Service d'Ophtalmologie [CHU Toulouse] Service d'Ophtalmologie [CHU Toulouse] Institut de Médecine et de Physiologie Spatiales Institut de Médecine et de Physiologie Spatiales Institut de Médecine et de Physiologie Spatiales Institut de Médecine et de Physiologie Spatiales Institut des Maladies Métaboliques et Cardiovasculaires Département Neurologie [CHU Toulouse] Institut des Maladies Métaboliques et Cardiovasculaires Institut des Maladies Métaboliques et Cardiovasculaires Institut des Maladies Métaboliques et Cardiovasculaires Service Pharmacologie Clinique [CHU Toulouse] Institut des Maladies Métaboliques et Cardiovasculaires Département Neurologie [CHU Toulouse] Service d'Ophtalmologie [CHU Toulouse]
• Publié dans Frontiers in Physiology le 27/10/2020

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Résumé : Neuro-ophthalmological changes named spaceflight associated neuro-ocular syndrome (SANS) reported after spaceflights are important medical issues. Dry immersion (DI), an analog to microgravity, rapidly induces a centralization of body fluids, immobilization, and hypokinesia similar to that observed during spaceflight. The main objectives of the present study were 2-fold: (1) to assess the neuro-ophthalmological impact during 5 days of DI and (2) to determine the effects of venoconstrictive thigh cuffs (VTC), used as a countermeasure to limit headward fluid shift, on DI-induced ophthalmological adaptations. Eighteen healthy male subjects underwent 5 days of DI with or without VTC countermeasures. The subjects were randomly assigned into two groups of 9: a control and cuffs group. Retinal and optic nerve thickness were assessed with spectral-domain optical coherence tomography (OCT). Optic nerve sheath diameter (ONSD) was measured by ocular ultrasonography and used to assess indirect changes in intracranial pressure (ICP). Intraocular pressure (IOP) was assessed by applanation tonometry. A higher thickness of the retinal nerve fiber layer (RNFL) in the temporal quadrant was observed after DI. ONSD increased significantly during DI and remained higher during the recovery phase. IOP did not significantly change during and after DI. VTC tended to limit the ONSD enlargement but not the higher thickness of an RNFL induced by DI. These findings suggest that 5 days of DI induced significant ophthalmological changes. VTC were found to dampen the ONSD enlargement induced by DI.

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Fichiers liés : 2021a. Effects of Venoconstrictive Thigh Cuffs on Dry Immersion-Induced Ophthalmological Changes.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 13/07/2021
• Auteurs : Jérémy RaffinYves RollandGeetika AggarwalAndrew NguyenJohn MorleyYan LiRandall BatemanBruno VellasPhilipe de Souto BarretoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey Gabelle-DeloustalAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean‐pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Institut du Vieillissement Gérontopôle Gérontopôle Equipe AGING (CERPOP) Saint Louis University Saint Louis University Saint Louis University China University of Petroleum Washington University School of Medicine in St. Louis Washington University School of Medicine in St. Louis Gérontopôle Equipe AGING (CERPOP) Gérontopôle Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Equipe AGING (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated. We explored the cross-sectional associations of PA with blood concentrations of neurofilament light chain (NFL) and beta amyloid (Aβ)42/40. We further examined whether the interaction between PA and these biomarkers was longitudinally related to cognition. Four-hundred and sixty-five nondemented older adults engaged in an interventional study and who had a concomitant assessment of PA levels and blood measurements of NFL (pg/mL) and Aβ 42/40 were analyzed. A composite Z-score combining 4 cognitive tests was used for cognitive assessment up to a 4-year follow-up. Multiple linear regressions demonstrated that people achieving 500–999 and 2000+ MET-min/week of PA had lower (ln)NFL concentrations than their inactive peers. Logistic regressions revealed that achieving at least 90 MET-min/week of PA was associated with a lower probability of having high NFL concentrations (ie, ≥91.961 pg/mL [third quartile]). PA was not associated with (Aβ)42/40. Mixed-model linear regressions demonstrated that the reverse relationship between PA and cognitive decline tended to be more pronounced as Aβ 42/40 increased, while it was dampened with increasing levels of (ln)NFL concentrations. This study demonstrates that PA is associated with blood NFL but not with Aβ 42/40. Furthermore, it suggests that PA may attenuate the negative association between amyloid load and cognition, while having high NFL levels mitigates the favorable relationship between PA and cognition. More investigations on non demented older adults are required for further validation of the present findings.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/07/2021
• Auteurs : Laure RouchPhilipe Barreto de SoutoOlivier HanonJean-Sébastien VidalJacques AmarSandrine AndrieuPhilippe CestacYves RollandBruno VellasBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise Lala
• Organismes : Equipe AGING (CERPOP) Equipe AGING (CERPOP) Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies Service Cardiologie [CHU Toulouse] Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP) Equipe AGING (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : This study aimed to determine whether visit-to-visit blood pressure (BP) variability (BPV) is associated with incident frailty. We included 1 394 nonfrail community-dwelling participants aged ≥70 years from the Multidomain Alzheimer Preventive Trial (MAPT) who underwent repeated clinical examinations, including BP and frailty, over a 5-year follow-up period. Systolic BPV (SBPV), diastolic BPV (DBPV), mean arterial pressure variability (MAPV), and pulse pressure variability (PPV) were evaluated using standard deviation (SD), coefficient of variation (CV), average real variability, successive variation, variation independent of mean, and residual SD. Incident frailty was assessed using the Fried phenotype. Cox proportional hazards models were used for the analyses. Higher SBPV was significantly associated with greater risk of frailty (1-SD increase of CV: hazard ratio [HR] = 1.18, 95% confidence interval [CI]: 1.02–1.36) after adjustment for demographics, systolic BP, antihypertensive drugs, body mass index, diabetes, ischemic heart disease, congestive heart failure, stroke, atrial fibrillation, MAPT randomization group, and frailty status. Similar results were observed with all indicators of variability. Higher PPV was associated with a greater risk of developing frailty over time (1-SD increase of CV: HR = 1.17, 95% CI: 1.01–1.35). DBPV and MAPV were not significantly associated with incident frailty. Higher SBPV and PPV were associated with greater risk of incident frailty. Our findings support the concept of BP physiological dysregulation underlying the frail state and suggest that BP instability could be an early marker of frailty.

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• Type de publi. : Article dans une revue
• Date de publi. : 12/07/2021
• Auteurs : Paul LoubetLinda WittkopEric TartourBeatrice ParfaitBenoît BarrouJean-Yves BlayMaryvonne HourmantMarie LachâtreDavid-Axel LaplaudMartine LavilleBruno LaviolleJean-Daniel LelievreJacques MorelStéphanie NguyenJean-Philippe SpanoBenjamin TerrierAnne ThiebautJean-Francois ViallardFrançois VrtovsnikXavier de LamballerieOdile Launay
• Organismes : Virulence bactérienne et maladies infectieuses Centre Hospitalier Universitaire de Bordeaux Bordeaux population health Hôpital Européen Georges Pompidou [APHP] Hôpital Cochin [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre Léon Bérard [Lyon] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Cochin [AP-HP] Centre de Recherche en Transplantation et Immunologie Association Francaise d'Etudes et de Recherches sur l'Obesite Hospices Civils de Lyon Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre d'Investigation Clinique Henri Mondor CHU Montpellier = Montpellier University Hospital Centre d'Immunologie et des Maladies Infectieuses Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital Cochin [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Bordeaux AP-HP - Hôpital Bichat - Claude Bernard [Paris] Unité des Virus Emergents Hôpital Cochin [AP-HP]
• Publié dans Nature Medicine le 29/10/2020

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Fichiers liés : s41591-021-01435-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/07/2021
• Auteurs : Yaseen M ArabiAnthony GordonLennie DerdeAlistair NicholSrinivas MurthyFarah Al BeidhDjillali AnnaneLolowa Al SwaidanAbi BeaneRichard BeasleyLindsay BerryZahra BhimaniMarc BontenCharlotte BradburyFrank BrunkhorstMeredith BuxtonAdrian BuzgauAllen ChengMenno de JongMichelle DetryEamon DuffyLise EstcourtMark FitzgeraldRob FowlerTimothy GirardEwan GoligherHerman GoossensRashan HaniffaAlisa HigginsThomas HillsChristopher HorvatDavid HuangAndrew KingFrancois LamontagnePatrick LawlerRoger LewisKelsey LinstrumEdward LittonElizabeth LorenziSalim MalakoutiDaniel McauleyAnna McglothlinShay McguinnessBryan McverryStephanie MontgomerySusan MorpethPaul MounceyKatrina OrrRachael ParkeJane ParkerAsad PatanwalaKathryn RowanMarlene SantosChristina SaundersChristopher SeymourManu Shankar-HariSteven TongAlexis TurgeonAnne TurnerFrank Leo van de VeerdonkRyan ZarychanskiCameron GreenScott BerryJohn MarshallColin McarthurDerek AngusSteven WebbFarah Al-BeidhDerek AngusDjillali AnnaneYaseen ArabiAbi BeaneWilma van Bentum-PuijkScott BerryZahra BhimaniMarc BontenCharlotte BradburyFrank BrunkhorstMeredith BuxtonAllen ChengLennie DerdeLise EstcourtHerman GoossensAnthony GordonCameron GreenRashan HaniffaFrancois LamontagnePatrick LawlerEdward LittonJohn MarshallColin McarthurDaniel McauleyShay McguinnessBryan McverryStephanie MontgomeryPaul MounceySrinivas MurthyAlistair NicholRachael ParkeJane ParkerKathryn RowanMarlene SantosChristopher SeymourAlexis TurgeonAnne TurnerFrank van de VeerdonkSteve WebbRyan ZarychanskiYaseen ArabiLewis CampbellAllen ChengLennie DerdeAndrew ForbesDavid GattasCameron GreenStephane HeritierPeter KrugerEdward LittonColin McarthurShay McguinnessAlistair NicholRachael ParkeJane ParkerSandra PeakeJeffrey PresneillIan SeppeltTony TrapaniAnne TurnerSteve WebbPaul YoungZahra BhimaniBrian CuthbertsonRob FowlerFrancois LamontagneJohn MarshallVenika ManoharanSrinivas MurthyMarlene SantosAlexis TurgeonRyan ZarychanskiDiptesh AryalAbi BeaneArjen DondropCameron GreenRashan HaniffaMadiha HashmiIssrah JawadDeva JayakumarJohn MarshallColin McarthurSrinivas MurthyTimo TolppaVanessa SinghSteve WebbFarah Al-BeidhDerek AngusDjillali AnnaneWilma van Bentum-PuijkScott BerryMarc BontenFrank BrunkhorstMaurizio CecconiLennie DerdeStephan EhrmannHerman GoossensAnthony GordonColin McarthurPaul MounceyAlistair NicholLorraine ParkerMathias PletzPedro PóvoaGernot RohdeKathryn RowanSteve WebbBrian AlexanderDerek AngusKim BasileMeredith BuxtonTimothy GirardChristopher HorvatDavid HuangKelsey LinstrumFlorian MayrBryan McverryStephanie MontgomeryChristopher SeymourRichard BeasleyMarc BontenAllen ChengNick DanemanLennie DerdeRobert FowlerDavid GattasAnthony GordonCameron GreenPeter KrugerColin McarthurSteve McgloughlinSusan MorpethSrinivas MurthyAlistair NicholMathias PletzDavid PatersonGernot RohdeSteve WebbDerek AngusWilma van Bentum-PuijkLennie DerdeAnthony GordonPeter KrugerEdward LittonJohn MarshallColin McarthurSrinivas MurthyAlistair NicholBala VenkateshSteve WebbDerek AngusScott BerryMarc BontenAllen ChengLennie DerdeHerman GoossensMenno de JongJohn MarshallColin McarthurSrinivas MurthyTim UyekiSteve WebbDerek AngusYaseen ArabiKenneth BaillieRichard BeasleyScott BerryMarc BontenAllen ChengMenno de JongLennie DerdeEamon DuffyRob FowlerHerman GoossensAnthony GordonCameron GreenThomas HillsColin McarthurSusan MorpethSrinivas MurthyAlistair NicholKatrina OrrRachael ParkeJane ParkerAsad PatanwalaKathryn RowanSteve TongTim UyekiFrank van de VeerdonkSteve WebbDerek AngusYaseen ArabiKenneth BaillieRichard BeasleyScott BerryMarc BontenFrank BrunkhorstAllen ChengNichola CooperOlaf CremerMenno de JongLennie DerdeEamon DuffyJames GaleaHerman GoossensAnthony GordonCameron GreenThomas HillsAndrew KingHelen LeavisJohn MarshallFlorian MayrColin McarthurBryan McverrySusan MorpethSrinivas MurthyMihai NeteaAlistair NicholKayode OgungbenroKatrina OrrJane ParkerAsad PatawalaVille PettiläEmma RademakerKathryn RowanManoj SaxenaChristopher SeymourWendy Sligl, Steven Tong, Tim Uyeki van de Veerdonk Steve WebbTaryn YoungsteinDerek AngusScott BerryLennie DerdeCameron GreenDavid HuangFlorian MayrBryan McverryStephanie MontgomeryChristopher SeymourSteve WebbDerek AngusDiptesh AryalScott BerryShilesh BihariCharlotte BradburyMarc CarrierDean FergussonRobert FowlerEwan GoligherAnthony GordonChristopher HorvatDavid HuangBeverley HuntDevachandran JayakumarAnand KumarMike LaffanPatrick LawlerSylvain LotherColin McarthurBryan McverryJohn MarshallSaskia MiddeldorpZoe McquiltenMatthew NealAlistair NicholChristopher SeymourRoger SchutgensSimon StanworthAlexis TurgeonSteve WebbRyan ZarychanskiNeill AdhikariDerek AngusDjillali AnnaneMatthew AnsteyYaseen ArabiScott BerryEmily BrantAngelique de ManLennie DerdeAnthony GordonCameron GreenDavid HuangFrancois LamontagneEdward LittonJohn MarshallMarie-Helene MasseColin McarthurShay McguinnessPaul MounceySrinivas MurthyRachael ParkeAlistair NicholTony TrapaniAndrew UdySteve WebbDerek AngusDonald ArnoldPhillipe BeginScott BerryRichard CharlewoodMichael ChasseMark CoyneJamie CooperJames DalyLise EstcourtDean FergussonAnthony GordonIain GosbellHeli Harvala-SimmondsTom HillsChristopher HorvatDavid HuangSheila MaclennanJohn MarshallColin McarthurBryan McverryDavid MenonSusan MorpethPaul MounceySrinivas MurthyJohn McdyerZoe McquiltenAlistair NicholNicole PrideeDavid RobertsKathryn RowanChristopher SeymourManu Shankar-HariHelen ThomasAlan TinmouthDarrell TriulziAlexis TurgeonTim WalshSteve WebbErica WoodRyan ZarychanskiDerek AngusYaseen ArabiAbi BeaneCarolyn CalfeeAnthony GordonCameron GreenRashan HaniffaDeva JayakumarPeter KrugerPatrick LawlerEdward LittonColin McarthurDaniel McauleyBryan McverryMatthew NealAlistair NicholCecilia O’kaneMurali ShyamsundarPratik SinhaTaylor ThompsonSteve WebbIan YoungDerek AngusScott BerryShailesh BihariCharlotte BradburyMarc CarrierTimothy GirardEwan GoligherAnthony GordonGhady HaidarChristopher HorvatDavid HuangBeverley HuntAnand KumarPatrick LawlerPatrick LawlessColin McarthurBryan McverryJohn MarshallZoe McquiltenMatthew NealAlistair NicholChristopher SeymourSimon StanworthSteve WebbAlexandra WeissmanRyan ZarychanskiDerek AngusWilma van Bentum-PuijkLewis CampbellLennie DerdeNiall FergusonTimothy GirardEwan GoligherAnthony GordonCameron GreenCarol HodgsonPeter KrugerJohn LaffeyEdward LittonJohn MarshallColin McarthurDaniel McauleyShay McguinnessAlistair NicholNeil OrfordKathryn RowanAry NetoSteve WebbRebecca BaronLennie DerdeSlava EpelmanClaudia FrankfurterDavid GattasFrank GommansAnthony GordonRashan HaniffaDavid HuangEdy KimFrancois LamontagnePatrick LawlerDavid LeafJohn MarshallColin McarthurBryan McverryDaniel McauleyMuthiah VaduganathanRoland van KimmenadeFrank van de VeerdonkSteve WebbMichelle DetryMark FitzgeraldRoger LewisAnna McglothlinAshish SanilChristina SaundersLindsay BerryScott BerryElizabeth LorenziJane ParkerVanessa SinghClaire ZammitZahra BhimaniMarlene SantosAbi BeaneRashan HaniffaTimo TolppaSara BariWilma van Bentum PuijkWietske BouwmanErika GroenveldDenise van HoutMarion Kwakkenbos-CranenMark LuttjeboerClementina OkundayeLorraine ParkerSvenja PetersSophie PostLinda RikkertIrma Scheepstra-BeukersGerwin SchreuderAlbertine SmitNicole Keijzer-TimmersCandy EstevezAhmed BachaChanez Lazizi ChemaniNawal DerridjNicole BrillingerRene MarkgrafKate AinscoughKathy BrickellPeter DoranAntonio LuqueFarah Al-BeidhAisha AnjumJanis-Best LaneElizabeth FagbodunLorna MillerPaul MounceyKaren Parry-BillingsSam PetersAlvin Richards-BelleMichelle SaullStefan SprinckmollerDaisy WileyCameron GreenAnne TurnerKim BasileMeredith BuxtonKelsey LinstrumStephanie MontgomeryJulian BionJason ConnorSimon GatesVictoria ManaxTom van der PollJohn ReynoldsMarloes van BeurdenEvelien LeffelaarJoost SchotsmanCraig BoydCain HarlandAudrey ShearerJess WrenGiles ClermontWilliam GarrardChristopher HorvatKyle KalchthalerAndrew KingDaniel RickettsSalim MalakoutisOscar MarroquinEdvin MusicKevin QuinnUdara AttanayakaAbi BeaneSri DarshanaRashan HaniffaPramodya IshaniIssrah JawadUpulee PabasaraTimo TolppaIshara UdayangaKate GilmourKaren PearsonChris SiewerskiSally-Anne HurfordEmma MarshDebbie CampbellPenny WilliamsKim ShirleyMeg LoganJane HansonBecky DilleyLouise PhillipsAnne OliverMihaela SutuSheenagh MurphyLatha AravindanJoanne CollinsHolly MonaghanAdam UnsworthSeonaid BeddowsLaura Ann DawsonSarah DyasAdeeba AsgharKate DonaldsonTabitha SkinnerNhlanhla MguniNatasha MuzengiJi LuoJoanna O’reillyChris LevettAlison PotterDavid PorterTeresa LockettJazz BartholomewClare RookRebecca MckayHannah WilliamsAlistair HallHilary CampbellHolly SpeightSandra HaldenSusan HarrisonMobeena NazKaatje LommePaula SharrattJohnathan SheffieldWilliam Van’t HoffJames WilliamsonAlex BarnardCatherine BirchMorwenna BrendEmma ChambersSarah CrawshawChelsea DrakeHayley Duckles-LeechJustin GrahamHeather HarperStephen LockNicola McmillanCliodhna O’flahertyEleanor OkellAmber HayesSally SamHeather SladeSusan WalkerKaren WildingJayne GoodwinHelen HodgsonYvette EllisDawn WilliamsonMadeleine BayneShane JacksonRahim ByrneSonia MckennaAlsion ClintonKate AinscoughKathy BrickellPeter DoranAndrew UdyPhoebe MccrackenMeredith YoungJasmin BoardEmma MartinKhaled El-KhawasAngus RichardsonDianne HillRobert CommonsHussam AbdelkharimCameron KnottJulie SmithCatherine BoschertJulia AffleckYogesh ApteUmesh SubbannaRoland BartholdyThuy FrakkingKaruna KeatDeepak BhonagiriRitesh SanghaviJodie NemaMegan FordHarshel ParikhBronwyn AvardMary NourseWinston CheungMark KolHelen WongAsim ShahAtul WaghJoanna SimpsonGraeme DukePeter ChanBrittney CarterStephanie HunterShailesh BihariRussell LaverTapaswi ShresthaXia JinEdward LittonAdrian RegliSusan PellicanoAnnamaria PalermoEge ErogluCraig FrenchSamantha BatesMiriam TownsYang YangForbes McgainJames McculloughMandy TallottNikhil KumarRakshit PanwarGail BrinkerhoffCassandra KoppenFederica CazzolaMatthew BrainSarah MineallRoy FischerVishwanath BiradarNatalie SoarHayden WhiteKristen EstensenLynette MorrisonJoanne SuttonMelanie CooperYahya ShehabiWisam Al-BassamAmanda HulleyUmesh KadamKushaharan SathianathanIan SeppeltChristina WhiteheadJulie LowreyRebecca GreshamKristy MastersPeter KrugerJames WalshamJason MeyerMeg HarwardEllen VenzKara BradyCassandra ValeKiran ShekarJayshree LavanaDinesh ParmarSandra PeakePatricia WilliamsCatherine KurendaHelen MilesAntony AttokaranSamuel GluckStephanie O’connorMarianne ChapmanKathleen GlasbyLewis CampbellKirsty SmythMargaret PhillipsJeffrey PresneillDeborah BargeKathleen ByrneAlana DriscollLouise FortunePierre JaninElizabeth YaradFrances BassNaomi HammondAnne O’connorSharon WatersonSteve WebbRobert McnamaraDavid GattasHeidi BuhrJennifer ColesSacha SchweikertBradley WibrowMatthew AnsteyRashmi RauniyarKush DeshpandePam KonecnyJennene MillerAdeline KintonoRaymond TungEd FyshAshlish DawdaBhaumik MevavalaAnnamaria PalermoAdrian RegliBart de KeulenaerEd LittonJanet FerrierPriya NairHergen BuscherClaire ReynoldsSally NewmanJohn SantamariaLeanne BarbazzaJennifer HomesRoger SmithPeter GarrettLauren MurrayJane BrailsfordLoretta ForbesTeena MaguireCraig FrenchGerard FennessyJohn MulderRebecca MorganRebecca MceldrewAnas NaeemLaura FaganEmily RyanVasanth MariappaJudith SmithScott SimpsonMatthew MaidenAllison BoneMichelle HortonTania SalernoMartin SterbaWenli GengPieter DepuydtJan de WaeleLiesbet de BusJan FierensStephanie BrackeJoris VermassenDaisy VermeirenBrenda ReeveWilliam DechertMichaël ChasséFrançois Martin CarrierDounia BoumahniFatna BenettaibAli GhamraouiAlexis TurgeonDavid BellemareÈve CloutierRana DaherFrançois LauzierCharles FrancoeurFrançois LamontagneFrédérick D’aragonElaine CarbonneauJulie LeblondGloria Vazquez-GrandeNicole MartenTheresa LiuAtif SiddiquiRyan ZarychanskiGloria Vazquez-GrandeNicole MartenMaggie WilsonMartin AlbertKarim SerriAlexandros CavayasMathilde DuplaixVirginie WilliamsBram RochwergTim KarachiSimon OczkowskiJohn CentofantiTina MillenKosar KhwajaJosie CampisiErick DuanJennifer TsangLisa PattersonEric SyChiraag GuptaSandy KassirDemetrios KutsogiannisPatricia ThompsonRob FowlerNeill AdhikariManeesha KamraNicole MarinoffRyan ZarychanskiNicole MartenDeborah CookFrances ClarkeRebecca KruisselbrinkAtif SiddiquiJohn MarshallLaurent BrochardKaren BurnsGyan SandhuImrana KhalidShane EnglishIrene WatpoolRebecca PorteousSydney MiezitisLauralyn McintyreElizabeth WilcoxLorenzo del SorboHesham AbdelhadyTina RomagnuoloWendy SliglNadia BaigOleksa RewaSean BagshawAlexandra BinnieElizabeth PowellAlexandra McmillanTracy LukNoah ArefDevachandran JayakumarSuresh BabuC. VigneshAugustian JamesR. EbenezerS. KrishnamurthyLakshmi RanganathanSushil KhanalSameena AmatyaHem Raj PaneruSabin KoiralaPratibha PaudelDiptesh AryalKanchan KoiralaNamrata RaiSubekshya LuitelHem Raj PaneruBinita BhattaraiMadiha HashmiAshok PanjwaniZulfiqar Ali UmraniShoaib SiddiqMohiuddin ShaikhNawal SalahuddinSobia MasoodZdravko AndricSabina CviljevicRenata ĐimotiMarija ZapalacGordan MirkovićBruno BaršićMarko KutlešaViktor KotarskiAna Vujaklija BrajkovićJakša BabelHelena SeverLidija DragijaIra KušanSuvi VaaraLeena PettiläJonna HeinonenVille PettiläAnne KuitunenSari KarlssonAnnukka VahteraHeikki KiiskiSanna RistimäkiAmine AzaizCyril CharronMathieu GodementGuillaume GeriAntoine Vieillard-BaronFranck PourcineMehran MonchiDavid LuisRomain MercierAnne SagnierNathalie VerrierCécile CaplinJack RichecoeuDaniele CombauxShidasp SiamiChristelle AparicioSarah VautierAsma JeblaouiDelphine Lemaire-BrunelMuriel FartoukhLaura CourtinVincent LabbeGuillaume VoiriotSara Nesrine SalhiGaetan PlantefeveCécile LeparcoDamien ContouGrégoire MullerMai-Anh NayToufik KamelDalila BenzekriSophie JacquierIsabelle RungeArmelle MathonnetFrançois BarbierAnne BretagnolEmmanuelle MercierDelphine ChartierCharlotte SalmonPierre-François DequinDenis GarotFrancis SchneiderVincent CastelainGuillaume MorelSylvie L’hotellierJulio BadieFernando Daniel BerdaguerSylvain MalfroyChaouki MezherCharlotte BourgoinGuy MonegerElodie BouvierBruno MegarbaneSebastian VoicuNicolas DeyeIsabelle MalissinLaetitia SutterlinAymen MradAdrien Pépin LehalleurGiulia NaimPhilippe NguyenJean-Michel EkhérianYvonnick BouéGeorgios SidérisDominique VodovarEmmanuelle GuérinCaroline GrantChristophe GuittonCédric DarreauMickaël LandaisNicolas ChudeauAlain RobertPatrice TirotJean Christophe CallahanMarjorie Saint MartinCharlène Le MoalRémy MarnaiMarie Hélène LeroyerDjillali AnnanePierre MoineNicholas HemingVirginie MaximeIsabelle BossardTiphaine Barbarin NicholierBernard ClairDavid OrlikowskiRania BounabLilia AbdeladimGwenhael ColinVanessa ZinzoniNatacha MaquigneauMatthieu Henri-LagarrigueCaroline PoupletJens SoukupRichard WetzoldMadlen LöbelLisa StarkePatrick GrimmAndré FinnGabriele KreßUwe HoffCarl Friedrich HinrichsJens NeeMathias PletzStefan HagelJuliane AnkertSteffi KolanosFrank BloosDaniela Nickoleit-BitzenbergerBernhard SchaafWerner MeermeierKatharina PrebegHarun Said AzzauiMartin HowerKlaus-Gerd BriegerCorinna ElenderTimo SabelhausAnsgar RiepeCeren AkampJulius KremlingDaniela KleinElke Landsiedel-MechenbierSirak PetrosKevin KunzBianka SchützeStefan KlugeAxel NierhausDominik JarczakKevin RoedlGernot Gerhard Ulrich RohdeAchim GrünewaldtJörg BojungaDirk WeismannAnna FreyMaria DrayssM. GoebelerThomas FlorGertrud FragnerNadine WahlJuliane TotzkeCyrus SayehliLorenz ReillMichael DistlerAstrid MaselliJános BélteczkiIstván MagyarÁgnes FazekasSándor KovácsViktória SzőkeGábor SzigligetiJános LeszkovenDaniel CollinsKathy BrickellLiadain ReidMichelle SmythPatrick BreenSandra SpainGerard CurleyNatalie McevoyPierce GeogheganJennifer ClarkeJohn LaffeyBairbre McnicholasMichael ScullySiobhan CaseyMaeve KernanAoife BrennanRitika RanganRiona TullySarah CorbettAine MccarthyOscar DuffyDavid BurkeAlistair NicholKathy BrickellMichelle SmythLeanne HayesLiadain ReidLorna MurphyAndy NeillBryan ReidyMichael O’dwyerDonal RyanKate AinscoughOscar HoitingMarco PetersEls RengersMirjam EversAnton PrinssenHuub van den OeverArriette Kruisdijk-GerritsenKoen SimonsTamara van ZuylenAngela BoumanLaura van GulikJeroen SchoutenPeter PickkersNoortje RooversMargreet Klop-RiehlHetty van der EngEvert de JongeJeanette WigbersMichael del PradoMarc BontenOlaf CremerLennie DerdeDiederik van DijkEmma RademakerJelle Haitsma MulierAnna Linda PetersBirgit RombergSjoerd van BreeMarianne Bouw-RuiterBarbara FestenFiona van GelderMark van IperenMargreet OsingaRoel SchellaarsDave TjanRuben van der WekkenMax MelchersArthur van ZantenShay McguinnessRachael ParkeEileen GuilderMagdalena ButlerKeri-Anne CowdreyMelissa WoollettColin McarthurThomas HillsLynette NewbyYan ChenCatherine SimmondsRachael McconnochieCaroline O’connorJay Ritzema CarterSeton HendersonKymbalee van der HeydenJan MehrtensAnna MorrisStacey MorganTony WilliamsAlex KazemiSusan MorpethRima SongVivian LaiDinuraj GirijadeviRobert EverittRobert RussellDanielle HackingUlrike BuehnerErin WilliamsTroy BrowneKate GrimwadeJennifer GoodsonOwen KeetOwen CallenderRobert MartynogaKara TraskAmelia ButlerPaul YoungChelsea YoungEden LesonaShaanti OlatunjiLeanlove NavarraRaulle Sol CruzKatherine PerryRalph FuchsBridget LambertJonathan AlbrettCarolyn JacksonSimon KirkhamNuno José Teodoro Amaro dos Santos CatorzeTiago Nuno Alfaro Lima PereiraRicardo Manuel Castro FerreiraJoana Margarida Pereira Sousa BastosTeresa Margarida Oliveira BatistaSimin Aysel FlorescuDelia StanciuMihaela Florentina ZahariaAlma Gabriela KosaDaniel CodreanuYaseen ArabiEman Al QasimLolowa AlswaidanMohamed HegazyHatim ArishiAli Al AmriSamah AlqahtaniBrintha NaiduHaytham TlayjehSajid HussainFarhan Al EneziSheryl Ann AbdukahilRosana Muñoz-BermúdezJudith Marin-CorralAnna Salazar DegraciaFrancisco Parrilla GómezMaria Isabel Mateo LópezRafael León LópezJorge RodriguezSheila CárcelRosario CarmonaCarmen de la FuenteMarina RodriguezCallum KayeAngela AllanCharlotte SummersPetra PolgarovaStephen McwilliamDaniel HawcuttLaura RadLaura O’malleyJennifer WhitbreadOlivia KelsallNicholas Cowley Laura WildJessica ThrushHannah WoodKaren AustinAdrian DonnellyMartin KellyNaoise SmythSinéad O’kaneDeclan McclintockMajella WarnockRyan CampbellEdmund MccallionPaul JohnsonShirley MckennaJoanne HanleyAndrew CurrieBarbara AllenClare Mc GoldrickMoyra Mc MasterRajeev JhaMichael KalogirouChristine EllisVinodh KrishnamurthyVashish DeelchandAibhilin O’connorDipak MukherjeeAgilan KaliappanAnirudda PaiMark VertueAnne NicholsonJoanne RichesGracie MaloneyLauren KittridgeAmanda SolesburyKezia AllenJon SilversidesPeter McguiganKathryn WardAisling O’neillStephanie FinnBarbara PhillipsLaura Oritz-Ruiz de GordoaJeremy BewleyMatthew ThomasKatie SweetLisa GrimmerRebekah JohnsonJez PinnellMatt RobinsonLisa GledhillTracy WoodMatt MorganJade ColeHelen HillMichelle DaviesAngharad WilliamsEmma ThomasRhys DaviesMatt WiseDavid AntcliffeMaie TempletonRoceld RojoPhoebe CoghlanJoanna SmeeEuan MackayJon CortAmanda WhilemanThomas SpencerNick SpittleSarah BeavisAnand PadmakumarKatie DaleJoanne HawesEmma MoakesRachel GascoyneKelly PritchardLesley StevensonJustin CookeKarolina Nemeth-RoszpopaVidya KasipandianAmit PatelSuzanne AlliboneRoman Mary-GenetuMohamed RamaliH. OoiAlison GhoshRawlings OsagieMalka Jayasinghe ArachchigeMelissa HartleyPeter BamfordEmily LondonKathryn CawleyMaria FaulknerHelen JeffreyAshok Sundar RajGeorgios TsinaslanidisReena Nair KhadeGloria Nwajei AghaRose Nalumansi SekiwalaTim SmithChris BrewerJane GregoryJames LimbAmanda CowtonJulie O’brienKelly PostlethwaiteNikitas NikitasColin WellsLiana LankesterHelen McmillanMark PulletzPatricia WilliamsJenny BirchSophie WisemanSarah HortonAna AlegriaSalah TurkiTarek ElsefiNikki CrispLouise AllenMatthew SmithSri ChukkambotlaWendy GoddardStephen DuberleyIain MccullaghPhilip RobinsonBijal PatelSinead KellyOmar ToumaSusan HollandChristopher HodgeHolly TaylorMeera AldermanNicky BarnesJoana da RochaCatherine SmithNicole BrooksThanuja WeerasingheJulie-Ann SinclairYousuf AbusamraRonan DohertyJoanna CudlippRajeev SinghHaili YuAdmad DaebisN. ChristopherSara KendrickAnita SaranAhmed MakkyDanni GreenerLouise Rowe-LeeteAlexandra EdwardsYvonne BlandRozzie DolmanTracy FosterVanessa LinnettAmanda SandersonJenny RitzemaHelen WildDivya KhareMeredith PinderSelvin SelvamoniAmitha GopinathRichard PughDaniel MenziesRichard LeanXinyi QiuJeremy James ScanlonKathryn PuxtySusanne CathcartChris Mc GovernSamantha CarmichaelDominic RimmerHakeem YusuffGraziella IsgroChris BrightlingMichelle BourneMichelle CranerRebecca BoylesTamas SzakmanyShiney CherianGemma WilliamsChristie JamesAbby WatersMalcolm WattersRachel ProutLouisa DaviesSuzannah PeglerLynsey KyeremehAiman MianManu Shankar-HariMarlies OstermannMarina MarottiNeus Grau NovellasAneta BociekStephen BrettSonia Sousa AriasRebecca Elin HallSusan JainAbhinav GuptaCatherine HolbrookJeremy HenningStephen BonnerKeith HugillEmanuel CirsteaDean WilkinsonJessica JonesMichal KarlikowskiHelen SutherlandElva WilhelmsenJane WoodsJulie NorthDhinesh SundaranLaszlo HollosSusan CoburnAnna WilliamsSamantha 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McnamarraArystarch MakowskiBeata MisztalIram AhmedKevin NeickerSam MillingtonRebecca SquiresMasroor PhulpotoRichard StewartEsther MwauraLouise MewLynn WrenFelicity WillamsAneta OborskaRino MaedaSelver Kalchko-VeyssalRaji Orat PrabakaranBernard HadebeEric MakmurGuy NichollsRichard InnesPatricia DobleLibby GrahamCharmaine ShoveltonVincent HamlynNancy HawkinsAnna Roynon-ReedSean CutlerSarah LewisJuan Martin LazaroTabitha NewmanPauline AustinSusan ChapmanLouise CabrelliSimon FletcherJurgens NortjeDeirdre Fottrell-GouldGeorgina RandellKatie StammersMohsin ZamanEinas ElmahiAndrea JonesKathryn HallGary MillsKim RyallsKate Harrington Helen BowlerJas SallRichard BourneZoe BorrillTracy DuncanThomas LambJoanne ShawClaire FoxKirstie SmithSarah HollandBethany BlackledgeLiam McmorrowLaura DurransJade HarrisJeronimo Moreno CuestaKugan XavierDharam PurohitMunzir ElhassanAnne HaldeosRachel VincentMarwa AbdelrazikSamuel JenkinsArunkumar GanesanRohit KumarDavid CarterDhanalakshmi BakthavatsalamMatthew RowlandPaula HuttonArchana BashyalNeil DavidsonClare HirdSally BeerManish ChhablaniGunjan PhalodAmy KirkbySimon ArcherKimberley NethertonBarbara PhilipsDee MullanDenise SkinnerJane GaylardJulie NewmanSonia Arun SatheLisa RocheEllie DaviesKeri TurnerHenrik ReschreiterJulie CamsooksaiSarah PatchSarah JenkinsCharlotte HumphreyDavid PogsonSteve RoseZoe DalyLutece BrimfieldAngie NownDhruv ParekhColin BerginMichelle BatesChristopher McgheeDaniella LynchKhushpreet BhandalKyriaki TsakiridouAmy BamfordLauren CooperTony WhitehouseTonny VeenithMalcolm SimSophie Kennedy HaySteven HendersonMaria NygrenEliza ValentineAmro KataryGill BellLouise WilcoxKaty EnglishAnn AdamsMandeep-Kaur PhullAbbas ZaidiTatiana PogrebanLace Paulyn RosarosoDaniel HarveyBenjamin LoweMegan MeredithLucy RyanAnil HormisRachel WalkerDawn CollierSarah KimptonSusan OakleyKevin RooneyNatalie RoddenEmma HughesNicola ThomsonDeborah McglynnCharlotte ClarkPatricia ClarkAndrew WaldenLiza KeatingMatthew FriseTolu OkekeNicola JacquesHolly ColesEmma TilneyEmma VowellMartin Schuster-BruceSally PittsRebecca MilnLaura PurandareLuke VamplewBrijesh PatelDebra DempsterMahitha GummadiNatalie DormandShu Fang WangMichael SpiveySarah BeanKaren BurtLorraine MooreChristopher DayCharly GibsonElizabeth GordonLetizia ZitterSamantha KeenanJayaprakash SinghCeri LynchLisa RocheJustyna MikusekBethan DeaconKeri TurnerTamas SzakmanyEvelyn BakerShiney CherianJohn HickeyShreekant ChampanerkarLindianne AitkenLorraine Lewis ProsserGary MillsAjay RaithathaKris BauchmullerNorfaizan AhmadMatt WilesJayne WillsonIrina GrecuJane MartinCaroline Wrey BrownAna-Marie AriasEmily BevanThomas CravenDavid HopeJo SingletonSarah ClarkCorrienne MccullochIngeborg WeltersDavid Oliver HamiltonKaren WilliamsVictoria WaughDavid ShawSuleman MullaAlicia WaiteJaime Fernandez RomanMaria Lopez MartinezZudin PuthuchearyTimothy MartinFilipa SantosRuzena UddinMaria FernandezFatima SeiduAlastair SomervilleMari Lis PakatsPriya DiasSalam BegumTasnin ShahidSanjay 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• Organismes : Laboratoire d'étude de la réponse neuroendocrine au sepsis Hôpital Raymond Poincaré [AP-HP]
• Publié dans Intensive Care Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 12/07/2021
• Auteurs : Jean-Pierre BakhoumNdeye DiopEl Hadji T. BodianOlivier MbayePape. DiawLamine CisseMame Gaye-SeyeDiene ThiareAtanasse ColyBernard Le JeunePhilippe Giamarchi
• Organismes : Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme Université Alioune Diop de Bambey Laboratoire d'Optique et de Magnétisme Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme Université Cheikh Anta Diop de Dakar [Sénégal] Université Alioune Diop de Bambey Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire Géomatériaux et Environnement Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme Laboratoire d'Optique et de Magnétisme
• Publié dans Analyst le 28/10/2020

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Résumé : This paper describes two prototypes of an on-site Early Warning Water Quality Monitoring System (EWWQMS) for pesticide quantification in natural waters. As many pesticides are non-fluorescent, the EWWQMS setup uses UV photoconversion to form highly fluorescent photoproducts. To enhance sensitivity, the two prototypes use micellar-enhanced fluorescence with surfactant (cetyl trimethyl ammonium chloride) in aqueous solution. To improve specificity, four UV LEDs at different wavelengths then excite the fluorescent photoproducts. The EWWQMS prototypes also employ UV absorption for quantification of non-photosensitive pesticides. The first prototype detects the pesticides via a diode array spectrometer. The second system is developed with higher resolution spectrometer and an intensified CCD camera detection to improve the sensitivity of the method. These experimental set-ups are described, explained and tested. Analytical applications were carried out online in CTAC aqueous solution, for the determination of isoproturon, flufenoxuron and profenofos. The calibration curves obtained are linear over one order of magnitude, and the detection limits are in the ng mL−1 range. The analytical performances of these new methods are good compared with other published classical micellar enhanced photo-induced fluorescence methods for the determination of pesticides in aqueous solutions. Our results show that these EWWQMS prototypes can be used as a warning system to protect against pesticide contamination exceeding the threshold of treatment capabilities at industrial facilities using natural waters.

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