Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2021
• Auteurs : Liheng YinAlexandra ZahradnikovaRiccardo RizzettoSimona BoncompagniCamille Rabesahala de MeritensYadan ZhangPierre JoanneElena Marqués-SuléYuriana Aguilar- SánchezMiguel Fernández-TenorioOlivier VillejoubertLinwei LiYue Yi WangPhilippe MatéoValérie NicolasPascale GerbaudF. Anthony Anthony LaiRomain PerrierJosefina Ramos-FrancoErnst NiggliHéctor H ValdiviaCarmen R ValdiviaJosefina Ramos-FrancoEsther ZorioSpyros ZissimopoulosFeliciano ProtasiJean-Pierre BenitahAna Maria Gómez
• Organismes : Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara] Institute of Life Science [Swansea] Institute of Life Science [Swansea] Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Rush University Medical Center [Chicago] Universität Bern = University of Bern = Université de Berne Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Ingénierie et Plateformes au Service de l'Innovation Thérapeutique Signalisation et physiopathologie cardiovasculaire Qatar University Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Universität Bern = University of Bern = Université de Berne University of Wisconsin-Madison University of Wisconsin-Madison Rush University Medical Center [Chicago] Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares Institute of Life Science [Swansea] Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara] Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire
• Publié dans Circulation Research le 29/10/2020

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Résumé : Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2R420Q. Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in knock-in mouse cardiomyocytes and by microelectrodes in mutant human induced pluripotent stem cell-derived cardiomyocytes), we observed an increased occurrence of delayed afterdepolarizations under isoproterenol stimulation, associated with increased Ca2+ waves during confocal Ca2+ recording in both mouse and human RyR2R420Q cardiomyocytes. In addition, Ca2+-induced Ca2+-release, as well as a rough indicator of fractional Ca2+ release, were higher and Ca2+ sparks longer in the RyR2R420Q-expressing cells. At the ultrastructural nanodomain level, we observed smaller RyR2 clusters and widened junctional sarcoplasmic reticulum measured by gated stimulated emission depletion super-resolution and electron microscopy, respectively. The increase in junctional sarcoplasmic reticulum width might be due to the impairment of RyR2R420Q binding to JPH2 (junctophilin-2), as there were less junctophilin-2 coimmunoprecipitated with RyR2R420Q. At the single current level, the RyR2R420Q channel dwells longer in the open state at low intracellular Ca2+ ([Ca2+]i), but there is predominance of a subconductance state. The latter might be correlated with an enhanced interaction between the N terminus and the core solenoid, a RyR2 interdomain association that has not been previously implicated in the pathogenesis of arrhythmias and sudden cardiac death. Conclusions: The RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation modifies the interdomain interaction of the channel and weakens its association with JPH2. These defects may underlie both nanoscale disarrangement of the dyad and channel dysfunction.

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Fichiers liés : yin et al. - Impaired Binding to Junctophilin2 and Nanostructur.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2021
• Auteurs : Jean Yves SalleAchille TchallaRemy ThirionAnnick OffretLaurence DussaulxFlorence TrivinCaroline GayotPhilippe FayemendyPierre JésusCécile BonhommeEtienne HazartCharlotte BaudryJean-Claude Desport
• Organismes : Service de Médecine Physique et Réadaptation Handicap, Activité, Vieillissement, Autonomie, Environnement Service de Médecine Gériatrique [CHU Limoges] Centre hospitalier Rene Pleven de Dinan CH de Saint-Malo [Broussais] Clinique Saint-Yves [Rennes] Clinique Saint-Yves [Rennes] Handicap, Activité, Vieillissement, Autonomie, Environnement Service de Médecine Gériatrique [CHU Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Lactalis Nutrition Santé LACTALIS RECHERCHE ET DEVELOPPEMENT LACTALIS RECHERCHE ET DEVELOPPEMENT Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges]
• Publié dans SN Comprehensive Clinical Medicine le 30/11/2020

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Résumé : Abstract Management of oropharyngeal dysphagia (OD) is mainly based on modifying liquid viscosity and solid consistency in order to preserve oral feeding while avoiding unsafe swallowing. Adding thickening powders (TP) to water is the most common practice in patients suffering from OD to liquids, but ready-to-use gelled waters (RGW) can also be proposed. The main objective of this study was to assess the efficacy of a RGW and a TP on swallowing in hospitalized patients with different OD etiologies. This open, crossover, multicenter trial recruited thirty hospitalized patients with OD to liquids, confirmed by positive 3-ounce water test or positive Practical Aspiration Screening Scheme test. The patient’s ability to swallow 120 g of a RGW (IDDSI level 4) and a drink prepared with TP (nectar viscosity; NTP, 291 cP, IDDSI level 2; or if necessary, honey; HTP, 769 cP, IDDSI level 3) was evaluated in a random order at 1- to 3-day intervals. The main criterion was the efficacy of each product, defined as the proportion of patients who successfully swallowed without immediate reflexive cough. The RGW and TP were successfully swallowed in respectively 93.3% (95% CI: 77.9–99.2) and 82.8% (95% CI: 64.2–94.2) of patients with different dysphagia etiologies (stroke, neurodegenerative diseases, or aging) and unable to swallow thin water. Taste and texture of both study products were well appreciated by patients, with a preference for the RGW over TP. Therefore, the use of these thickened products could be part of the therapeutic strategy for patients with OD to liquids.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 22/07/2021
• Auteurs : Constance DouwesPhilippe EslingJean-Pierre Briot
• Organismes : Sciences et Technologies de la Musique et du Son Sciences et Technologies de la Musique et du Son Systèmes Multi-Agents

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Résumé : In recent years, the deep learning community has largely focused on the accuracy of deep generative models, resulting in impressive improvements in several research fields. However, this scientific race for quality comes at a tremendous computational cost, which incurs vast energy consumption and greenhouse gas emissions. If the current exponential growth of computational consumption persists, Artificial Intelligence (AI) will sadly become a considerable contributor to global warming. At the heart of this problem are the measures that we use as a scientific community to evaluate our work. Currently, researchers in the field of AI judge scientific works mostly based on the improvement in accuracy, log-likelihood, reconstruction or opinion scores, all of which entirely obliterates the actual computational cost of generative models. In this paper, we introduce the idea of relying on a multi-objective measure based on Pareto optimality, which simultaneously integrates the models accuracy, as well as the environmental impact of their training. By applying this measure on the current state-of-the-art in generative audio models, we show that this measure drastically changes the perceived significance of the results in the field, encouraging optimal training techniques and resource allocation. We hope that this type of measure will be widely adopted, in order to help the community to better evaluate the significance of their work, while bringing computational cost-and in fine carbon emissions-in the spotlight of AI research.

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Fichiers liés : 2107.02621.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/07/2021
• Auteurs : Thomas BarbaEmmanuel BachyAlizée MaarekGaëlle FossardLaurent GenestierDany AnglicheauValérie MoalJacques DantalPhilippe RieuJonathan ChemounyManon CharrierAntoine DurrbachFrançois ProvotDidier DuclouxPierre-François WesteelAnne-Elisabeth HengJean-Philippe RerolleBenoît BarrouPhilippe GrimbertValérie ChateletChristiane MoussonBénédicte JanbonVincent PerninLuc FrimatNacera OualiDenis GlotzAntoine ThierryChristophe MariatMathias BüchlerPhilippe GaulardVéronique LeblondEmmanuel MorelonValérie DuboisGilles SallesSophie CaillardOlivier Thaunat
• Organismes : Centre International de Recherche en Infectiologie Hôpital Edouard Herriot [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Lyon Sud [CHU - HCL] Université Claude Bernard Lyon 1 Immuno-Biologie des Lymphomes [CIRI] Hôpital Henri Mondor Centre Hospitalier Lyon Sud [CHU - HCL] Université Claude Bernard Lyon 1 Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon Immuno-Biologie des Lymphomes [CIRI] Institut Necker Enfants-Malades Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire d'Angers Réseau CENTAURE Centre de Recherche en Transplantation et Immunologie Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Ethologie animale et humaine Immunologie intégrative des tumeurs et immunothérapie des cancers Service de Néphrologie et Transplantation rénale [CHRU-lille] Centre Hospitalier Régional Universitaire de Besançon CHU Amiens-Picardie CHU Gabriel Montpied [Clermont-Ferrand] Unité de Nutrition Humaine Université de Limoges CHU Pitié-Salpêtrière [AP-HP] CHU Henri Mondor [Créteil] Centre Universitaire des Maladies Rénales [CHU Caen] Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Hospitalier Universitaire [Strasbourg] CHU Dijon Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [Strasbourg] CHU Montpelier Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Nancy Centre Hospitalier Universitaire [Strasbourg] Assistance publique - Hôpitaux de Paris (AP-HP) Centre Hospitalier Universitaire [Strasbourg] Assistance publique - Hôpitaux de Paris (AP-HP) Centre Hospitalier Universitaire [Strasbourg] Département de Néphrologie [CHU Poitiers] Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire [Strasbourg] CHU Trousseau [Tours] Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Center for Interdisciplinary Research and Innovation Hôpital Edouard Herriot [CHU - HCL] EFS Hospices Civils de Lyon Immuno-Biologie des Lymphomes [CIRI] Centre Hospitalier Universitaire [Strasbourg] Center for Interdisciplinary Research and Innovation Hospices Civils de Lyon Centre International de Recherche en Infectiologie Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI] Service de transplantation, néphrologie et immunologie clinique Service de transplantation Service de Transplantation, Néphrologie et Immunologie Clinique [Lyon] Service de Transplantation, Néphrologie et Immunologie Clinique [Hôpital Edouard Herriot, HCL] Lyon Immunopathology Federation
• Publié dans Transplantation le 25/10/2020

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Résumé : Background. Posttransplant lymphoproliferative disorders (PTLDs) encompass a spectrum of heterogeneous entities. Because the vast majority of cases PTLD arise from B cells, available data on PTLD of T or NK phenotype (T/NK-cell PTLD) are scarce, which limits the quality of the management of these patients. Methods. All adult cases of PTLD diagnosed in France were prospectively recorded in the national registry between 1998 and 2007. Crosschecking the registry data with 2 other independent national databases identified 58 cases of T/NK-cell PTLD. This cohort was then compared with (i) the 395 cases of B-cell PTLD from the registry, and of (ii) a cohort of 148 T/NK-cell lymphomas diagnosed in nontransplanted patients. Results. T/NK-cell PTLD occurred significantly later after transplantation and had a worse overall survival than B-cell PTLD. Two subtypes of T/NK-cell PTLD were distinguished: (i) cutaneous (28%) and (ii) systemic (72%), the latter being associated with a worse prognosis. Compared with T/NK-cell lymphomas of nontransplanted patients, overall survival of systemic T/NK-cell PTLD was worse (hazard ratio: 2.64 [1.76-3.94]; P < 0.00001). Conclusions. This difference, which persisted after adjustment on tumoral mass, histological subtype, and extension of the disease at diagnosis could be explained by the fact that transplanted patients were less intensively treated and responded less to chemotherapy.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2021
• Auteurs : Floriane GibaultManon SturbautMathilde CoevoetMartine PugnièreAshley BurtscherFrédéric AllemandPatricia MelnykWanjin HongBrian RubinAjaybabu PobbatiJean-François GuichouPhilippe CotelleFabrice Bailly
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Institut de Recherche en Cancérologie de Montpellier Centre de Biochimie Structurale [Montpellier] Lille Neurosciences & Cognition - U 1172 Agency for science, technology and research [Singapore] ‎ National Heart Centre Singapore Departments of Pathology and Cancer Biology [Cleveland, OH, USA] Université de Lille Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172
• Publié dans ChemMedChem le 29/10/2020

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Résumé : Abstract Starting from our previously reported hit, a series of 1,5‐diaryl‐1,2,3‐triazole‐4‐carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ‐TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetry, and some of the compounds were also found to moderately disrupt the YAP‐TEAD interaction, as assessed by a fluorescence polarization assay. A TEAD luciferase gene reporter assay performed in HEK293T cells and RTqPCR measurements in MDA‐MB231 cells showed that these compounds inhibit YAP/TAZ‐TEAD activity to cells in the micromolar range. In spite of the cytotoxic effects displayed by some of the compounds of this series, they are still good starting points and can be suitably modified into an effective and viable YAP‐TEAD disruptor in the future.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2021
• Auteurs : Aparna BhattacharyaDavid BennettJean-Philippe BeaulieuIan BondNaoki KoshimotoJessica LuJoshua BlackmanAikaterini VandorouSean TerryVirginie BatistaJean Baptiste MarquetteAndrew ColeAkihiko FukuiCalen Henderson‪clément Ranc
• Organismes : NASA Goddard Space Flight Center Aston Business School The University of Tokyo University of Tasmania [Hobart] Institut d'Astrophysique de Paris
• Publié dans The Astronomical Journal le 22/10/2020

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Fichiers liés : Bhattacharya_2021_AJ_162_60.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2021
• Auteurs : Laurent MarivauxJorge Vélez-JuarbeLázaro W Viñola LópezPierre-Henri FabreFrançois PujosHernán Santos- MercadoEduardo J CruzAlexandra M Grajales PérezJames PadillaKevin I Vélez-RosadoJean-Jacques CorneeMélody PhilipponPhilippe MunchPierre-Olivier Antoine
• Organismes : Institut des Sciences de l'Evolution de Montpellier Natural History Museum of Los Angeles County University of Florida [Gainesville] Institut des Sciences de l'Evolution de Montpellier Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales [Mendoza] University of Puerto Rico at Mayagüez University of Puerto Rico at Mayagüez University of Puerto Rico at Mayagüez University of Puerto Rico at Mayagüez Université du Michigan = University of Michigan [Ann Arbor] Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Institut des Sciences de l'Evolution de Montpellier
• Publié dans Papers in Palaeontology le 04/03/2016

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Résumé : The West Indies are a natural laboratory for the study of biogeography and evolution, especially for mammals. The modality of their arrival in the Caribbean islands is a highly controversial issue, and palaeontological evidence remains particularly elusive. Lower Oligocene deposits of Puerto Rico (c. 29.5 Ma) have recently yielded the oldest archipelago rodents, with teeth of two chinchilloid caviomorphs of South American origin. Here we report the discovery of additional dental remains from the same level, testifying to the occurrence of another rodent group. Their morphology is singular but otherwise characteristic of North/Central American geomyin geomorphs (including extant kangaroo rats, pocket mice, and pocket gophers), and leads us to propose here a new taxon: Caribeomys merzeraudi gen. et sp. nov. The evidence of geomorphs in the West Indies challenges the view that all extinct and extant Antillean rodents derived from South American sources. The morphological singularity of this Puerto Rican geomorph also suggests an early split of this insular lineage from coeval mainland counterparts, and its dispersal towards the West Indies sometime around the Eocene–Oligocene transition. This unexpected rodent adds to the few cases of Antillean terrestrial vertebrates of North American origins, such as solenodonotan eulipotyphlans. In the absence of subaerial land connections between both landmasses, an overwater dispersal may explain mid-Palaeogene colonization of the West Indies by geomorph rodents.

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Fichiers liés : Marivaux-et-al-2021-Papers-in-Palaeontology_Geomorpha-Oligo-Puerto-Rico.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2021
• Auteurs : Nagham KhanaferPhilippe VanhemsSabrina BenniaGéraldine Martin-GaujardLaurent JuillardThomas RimmeléLaurent ArgaudOlivier MartinLaetitia HuriauxGuillaume MarcotteRomain HernuBernard FloccardPierre CassierStudy Group
• Organismes : Fondation Mérieux Centre International de Recherche en Infectiologie Hôpital Edouard Herriot [CHU - HCL] ESCMID Study Group for Clostridioides Difficile (ESGCD) Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hôpital Edouard Herriot [CHU - HCL] Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hôpital Edouard Herriot [CHU - HCL] Université Claude Bernard Lyon 1 Cardiovasculaire, métabolisme, diabétologie et nutrition Service de Néphrologie Hospices Civils - hta - dialyse Hôpital Edouard Herriot [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition Hôpital Edouard Herriot [CHU - HCL] Centre de recherche sur les liens sociaux Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse Hôpital Edouard Herriot [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL]
• Publié dans International Journal of Environmental Research and Public Health le 01/11/2020

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Résumé : Introduction: Clostridioides (Clostridium) difficile can be isolated from stool in 3% of healthy adults and in at least 10% of asymptomatic hospitalized patients. C. difficile, the most common cause of hospital-acquired infectious diarrhea in the developed world, has re-emerged in recent years with increasing incidence and severity. In an effort to reduce the spread of the pathogen, published recommendations suggest isolation and contact precautions for patients suffering from C. difficile infection (CDI). However, asymptomatic colonized patients are not targeted by infection control policies, and active surveillance for colonization is not routinely performed. Moreover, given the current changes in the epidemiology of CDI, particularly the emergence of new virulent strains either in the hospital or community settings, there is a need for identification of factors associated with colonization by C. difficile and CDI. Methods and analysis: We are carrying out a prospective, observational, cohort study in Edouard Herriot Hospital, Hospices Civils de Lyon, a 900-bed university hospital in Lyon, France. All consecutive adult patients admitted on selected units are eligible to participate in the study. Stool samples or rectal swabs for C. difficile testing are obtained on admission, every 3–5 days during hospitalization, at the onset of diarrhea (if applicable), and at discharge. Descriptive and logistic regression analyses will be completed to mainly estimate the proportion of asymptomatic colonization at admission, and to evaluate differences between factors associated with colonization and those related to CDI. Ethics: The study is conducted in accordance with the ethical principles of the Declaration of Helsinki, French law, and the Good Clinical Practice guidelines. The study protocol design was approved by the participating units, the ethics committee and the hospital institutional review board (Comité de protection des personnes et Comission Nationale de l’Informatique et des Libertés; N°: 00009118). Dissemination: The results of this study will be disseminated by presenting the findings locally at each participating ward, as well as national and international scientific meetings. Findings will be shared with interested national societies crafting guidelines in CDI.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2021
• Auteurs : Ziqi ZhouPaul MarconXavier DevauxPhilippe PigeatAlexandre BouchéSylvie MigotAbdallah JaafarRémi ArrasMichel VergnatLei RenHans TornatzkyCédric RobertXavier MarieJean-Marie GeorgeHenri-Yves JaffrèsMathieu StoffelHervé RinnertZhongming WeiPierre RenucciLionel CalmelsYuan Lu
• Organismes : Institut Jean Lamour University of Chinese Academy of Sciences [Beijing] Matériaux et dispositifs pour l'Electronique et le Magnétisme Institut Jean Lamour Institut Jean Lamour Institut Jean Lamour Institut Jean Lamour Institut Jean Lamour Matériaux et dispositifs pour l'Electronique et le Magnétisme Institut Jean Lamour Laboratoire de physique et chimie des nano-objets Laboratoire de physique et chimie des nano-objets Laboratoire de physique et chimie des nano-objets Laboratoire de physique et chimie des nano-objets Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Laboratoire Albert Fert (ex-UMPhy Unité mixte de physique CNRS/Thales) Institut Jean Lamour Institut Jean Lamour University of Chinese Academy of Sciences [Beijing] Laboratoire de physique et chimie des nano-objets Matériaux et dispositifs pour l'Electronique et le Magnétisme Institut Jean Lamour
• Publié dans ACS Applied Materials & Interfaces le 01/11/2020

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Résumé : Perpendicularly magnetized spin injector with high Curie temperature is a prerequisite for developing spin optoelectronic devices on 2D materials working at room temperature (RT) with zero applied magnetic field. Here, we report the growth of Ta/CoFeB/MgO structures with a large perpendicular magnetic anisotropy (PMA) on full coverage monolayer (ML) MoS2. A large perpendicular interface anisotropy energy of 0.975mJ/m 2 has been obtained at the CoFeB/MgO interface, comparable to that observed in magnetic tunnel junction systems. It is found that the insertion of MgO between the ferromagnetic metal (FM) and the 2D material can effectively prevent the diffusion of the FM atoms into the 2D material. Moreover, the MoS2 ML favors a MgO(001) texture and plays a critical role to establish the large PMA. First principle calculations on a similar Fe/MgO/MoS2 structure reveal that the MgO thickness can modify the MoS2 band structure, from an indirect bandgap with 7ML-MgO to a direct bandgap with 3ML-MgO. Proximity effect induced by Fe results in a splitting of 10meV in the valence band at the Γ point for the 3ML-MgO structure while it is negligible for the 7ML-MgO structure. These results pave the way to develop RT spin optoelectronic devices on 2D transition-metal dichalcogenide materials.

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Fichiers liés : PMA CoFeB on full coverage monolayer MoS2-ACS AMI revised-for arxiv.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 14/07/2021
• Auteurs : Jean David Lau Hiu HoongJérôme LuxPierre-Yves MahieuxPhilippe TurcryAbdelkarim Aït-Mokhtar
• Organismes : Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356

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