Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Nadine HamiehSofiane KabMarie ZinsJacques BlacherPierre MenetonJean‐philippe EmpanaNicolas HoertelFrederic LimosinMarcel GoldbergMaria MelchiorCedric Lemogne
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique Cohortes épidémiologiques en population Cohortes épidémiologiques en population Hôpital Hôtel-Dieu [Paris] Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé Paris-Centre de Recherche Cardiovasculaire Institut de psychiatrie et neurosciences de Paris Hôpital Corentin Celton [Issy-les-Moulineaux] Institut de psychiatrie et neurosciences de Paris Hôpital Corentin Celton [Issy-les-Moulineaux] Cohortes épidémiologiques en population Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut de psychiatrie et neurosciences de Paris Hôpital Hôtel-Dieu [Paris]
• Publié dans European Heart Journal - Cardiovascular Pharmacotherapy le 31/10/2019

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Résumé : Aims: Depression is associated with increased risk of cardiovascular disease (CVD) and the role of poor medical adherence is mostly unknown. We studied the association between depressive symptoms and non-adherence to medications targeting treatable cardiovascular risk factors in the CONSTANCES population-based French cohort. Methods and results: We used CONSTANCES data linked to the French national healthcare database to study the prospective association between depressive symptoms (assessed at inclusion with the Center for Epidemiological Studies Depression scale) and non-adherence to medications (less than 80% of trimesters with at least one drug dispensed) treating type 2 diabetes, hypertension, and dyslipidaemia over 36 months of follow-up. Binary logistic regression models were adjusted for socio-demographics, body mass index, and personal history of CVD at inclusion. Among 4998 individuals with hypertension, 793 with diabetes, and 3692 with dyslipidaemia at baseline, respectively 13.1% vs. 11.5%, 10.5% vs. 5.8%, and 29.0% vs. 27.1% of those depressed vs. those non-depressed were non-adherent over the first 18 months of follow-up (15.9% vs. 13.6%, 11.1% vs. 7.4%, and 34.8% vs. 36.6% between 19 and 36 months). Adjusting for all covariates, depressive symptoms were neither associated with non-adherence to medications for hypertension, diabetes, and dyslipidaemia over the first 18 months of follow-up, nor afterwards. Depressive symptoms were only associated with non-adherence to anti-diabetic medications between the first 3-6 months of follow-up. Conclusion: Non-adherence to medications targeting treatable cardiovascular risk factors is unlikely to explain much of the association between depressive symptoms and CVD at a population level. Clinicians are urged to search for and treat depression in individuals with diabetes to foster medications adherence.

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Fichiers liés : Depression%20and%20adherence.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Candice HoberLisa FredeauAnne Pham-LedardMarouane BoubayaFlorian HermsPhilippe CelerierFrançois AubinNathalie BenetonMonica DinulescuArnaud JannicNicolas MeyerAnne-Bénédicte Duval-ModesteLaure CesaireÈve-Marie NeidhardtÉlodie ArchierBrigitte DrénoCandice LesageClémence BerthinNora KramkimelFlorent GrangeJulie de QuatrebarbesPierre-Emmanuel StoebnerNicolas PoulalhonJean Philippe ArnaultSafia AbedBertille BonniaudSophie DarrasValentine HeidelbergerSuzanne DevauxMarie MoncourierLaurent MiserySandrine MansardMaxime EtienneFlorence Brunet-PossentiCaroline JacobzoneRomain LesbazeillesFrançois SkowronJulia SanchezStéphanie CatalaMahtab SamimiYoussef TaziDominique SpaethCaroline Gaudy-MarquesteOlivier CollardRaoul TrillerMarc PrachtMarc DumasLucie PeuvrelPierre CombeOlivier LauchePierre GuilletYves ReguerreIngrid Kupfer-BessaguetDavid SolubAmélie SchoefflerChristophe BedaneGaëlle QuéreuxSophie DalacLaurent MortierEve Maubec
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Avicenne [AP-HP] Centre Hospitalier Universitaire de Bordeaux Université de Bordeaux Hôpital Avicenne [AP-HP] Hopital Saint-Louis [AP-HP] Hôpital Saint-Louis de La Rochelle Université de Bourgogne Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hôpital Henri Mondor Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Hôpital Charles Nicolle [Rouen] Hôpital Côte de Nacre [CHU Caen] Centre Léon Bérard [Lyon] Hôpital Saint-Joseph [Marseille] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Nantes Centre d’Investigation Clinique de Nantes Clinical and Translational Research in Skin Cancer Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire d'Angers Hôpital Cochin [AP-HP] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier de Valence CH Annecy Genevois CHU de Nîmes Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] Centre Hospitalier Lyon Sud [CHU - HCL] Hospices Civils de Lyon CHU Amiens-Picardie Hopital d'instruction des armées Sainte-Anne [Toulon] CH Boulogne sur Mer Hôpital Robert Ballanger [Aulnay-sous-Bois] Centre Hospitalier de la Côte Basque Centre Hospitalier Universitaire [CHU Grenoble] Université de Brest CHU Clermont-Ferrand Centre Hospitalier Intercommunal de Cornouaille Centre Hospitalier Intercommunal de Cornouaille [Quimper] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Georges Renon [Niort] Centre Hospitalier de Valence Hôpital universitaire Robert Debré [Reims] Clinique Saint Pierre, Perpignan Centre Hospitalier Régional Universitaire de Tours Infectiologie et Santé Publique Clinique Sainte Anne [Strasbourg] Centre d'Oncologie de Gentilly Institut de Cancérologie de la Loire Lucien Neuwirth Institut hospitalier Franco-Britannique [Levallois-Perret] CH René Dubos Institut de Cancérologie de l'Ouest [Angers/Nantes] Pôle Santé Léonard de Vinci Centre Hospitalier Universitaire de La Réunion Centre Hospitalier Georges Renon [Niort] Centre hospitalier régional de Metz-Thionville CHU Limoges Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Nantes Centre d’Investigation Clinique de Nantes Centre de Recherche en Cancérologie et Immunologie Nantes-Angers Centre Hospitalier Régional Universitaire [CHU Lille] Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 Hôpital Avicenne [AP-HP] UFR Santé, Médecine et Biologie Humaine Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
• Publié dans Cancers le 21/10/2020

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Résumé : Although cemiplimab has been approved for locally advanced (la) and metastatic (m) cutaneous squamous-cell carcinomas (CSCCs), its real-life value has not yet been demonstrated. An early-access program enrolled patients with la/mCSCCs to receive cemiplimab. Endpoints were best overall response rate (BOR), progression-free survival (PFS), overall survival (OS), duration of response (DOR) and safety. The 245 patients (mean age 77 years, 73% male, 49% prior systemic treatment, 24% immunocompromised, 27% Eastern Cooperative Oncology Group performance status (PS) ≥ 2) had laCSCCs (35%) or mCSCCs (65%). For the 240 recipients of ≥1 infusion(s), the BOR was 50.4% (complete, 21%; partial, 29%). With median follow-up at 12.6 months, median PFS was 7.9 months, and median OS and DOR were not reached. One-year OS was 73% versus 36%, respectively, for patients with PS < 2 versus ≥ 2. Multivariate analysis retained PS ≥ 2 as being associated during the first 6 months with PFS and OS. Head-and-neck location was associated with longer PFS. Immune status had no impact. Severe treatment-related adverse events occurred in 9% of the patients, including one death from toxic epidermal necrolysis. Cemiplimab real-life safety and efficacy support its use for la/mCSCCs. Patients with PS ≥ 2 benefited less from cemiplimab, but it might represent an option for immunocompromised patients.

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Fichiers liés : 2021_Hober_Cancers_vol-13art-3547.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Saleh AbdallaAbdolnabi Abdeh KolahchiMichaël AblainSusheel AdusumilliSuchandra Aich BhowmickEva Alou-FontLaiba AmaroucheOle AndersenHelena AntichLotfi AoufBrian ArbicThomas ArmitageSabine ArnaultCamila ArtanaGiuseppe AulicinoN.K. AyoubSergei BadulinSteven BakerChris BanksLifeng BaoSilvia BarbettaBàrbara Barceló-LlullFrançois BarlierSujit BasuPeter Bauer-GottweinMatthias BeckerBrian BeckleyNicole BellefondTatyana BelonenkoMounir BenkiranTouati BenkouiderRalf BennartzJérôme BenvenisteNicolas BercherMuriel Bergé-NguyenJoao BettencourtFabien BlarelAlejandro BlazquezDenis BlumsteinPascal BonnefondFranck BordeJérôme BouffardFrançois BoyJean-Paul BoyCédric BrachetPierre BrasseurAlexander BraunSara ModanesiDavid BrockleyLaurent BrodeauShannon BrownSean BruinsmaAnna BulczakSammie BuzzardMadeleine CahillStéphane CalmantMichel CalzasStefania CamiciMathilde CancetHugues CapdevilleClaudia Cristina CarabajalLoren CarrèreAnny CazenaveEric ChassignetPrakash ChauhanSelma CherchaliTeresa ChereskinCecile CheymolDaniele CianiPaolo CipolliniFrancesca CirilloEmmanuel CosmeSteve CossYuri CotroneoDavid CottonAlexandre CouhertSophie Coutin-FayeJean-François CrétauxFrédéric CyrFrancesco d'OvidioJosé DarrozesCedric DavidNadim DayoubDanielle de StaerkeXiaoli DengShailen DesaiJean-Damien DesjonqueresDenise DettmeringAlessandro Di BellaLara Díaz-BarrosoGérald DibarboureHabib Boubacar DiengSalvatore DinardoHenryk DobslawGuillaume DodetAndrea M. DoglioliAlessio DomeneghettiDavid DonahueShenfu DongCraig DonlonJoël DorandeuChristine DrezenMark DrinkwaterYves Du PenhoatBrian DushawAlejandro EgidoSvetlana ErofeevaPhilippe EscudierSaskia EsselbornPierre ExertierRonan FabletCédric FalcoSinead Louise FarrellYannice FaugèrePierre FemeniasLuciana FenoglioJoana FernandesJuan Gabriel FernándezPascale FerrageRamiro FerrariLionel FichenPaolo FilippucciStylianos FlampourisSara FleuryMarco FornariRene ForsbergFrédéric FrappartMarie-Laure FreryPablo GarciaAlbert Garcia-MondejarJulia GaudelliLucile GaultierAugusto GetiranaFerran GibertArtur GilLin GilbertSarah GilleLuisella GiulicchiJesús Gómez-EnriLaura Gómez-NavarroChristine GommengingerL. GourdeauDavid GriffinAndreas GrohAlexandre GuerinRaul GuerreroThierry GuinlePraveen GuptaBenjamin GutknechtMathieu HamonGuoqi HanDanièle HauserVeit HelmStefan HendricksFabrice HernandezAnna HoggMartin HorwathMartina IdžanovićPeter JanssenEric JeansouYongjun JiaYuanyuan JiaLiguang JiangJohnny JohannessenMasafumi KamachiSvetlana KarimovaKathryn KellySung Yong KimRobert KingCecile M.M. KittelPatrice KleinAnna KlosPer KnudsenRolf KoenigAndrey KostianoyAlexei V. KouraevRaj KumarSylvie LabroueLoreley Selene LagoJuliette LambinLéa LassonOlivier LaurainR. LaxenaireClara LázaroSophie Le GacJulien Le SommerPierre-Yves Le TraonSergey LebedevFabien LégerBenoît LegrésyFrank LemoineLuc LenainEric LeulietteMarina LévyJohn LillibridgeJianqiang LiuWilliam LlovelFlorent H LyardClaire MacintoshEduard Makhoul VaronaCécile ManfrediFrédéric MarinEvan MasonChristian MassariConstantin MavrocordatosNikolai MaximenkoMalcolm McmillanThierry MedinaAngélique MeletMarco MeloniStelios MertikasSammy MetrefBenoit MeyssignacJean-François MinsterThomas MoreauDaniel MoreiraYves MorelRosemary MorrowJohn MoyardSandrine MuletMarc NaeijeRobert Steven NeremHans NgodockKarina NielsenJan Even Øie NilsenFernando NiñoCarolina Nogueira LoddoCamille NoûsEstelle ObligisInès OtosakaMichiel OttenBerguzar Oztunali OzbahceciRoshin P. RajRodrigo PaivaGuillermina F PaniaguaFernando PaoloA. ParisAnanda PascualMarcello PassaroStephan PaulTamlin PavelskyChristopher PearsonThierry PenduffFukai PengFelix PerosanzNicolas PicotFanny PirasValerio PoggialiÉtienne PoirierSonia Ponce de LeónSergey PrantsCatherine PrigentChristine ProvostMarie-Isabelle PujolBo QiuYves QuilfenAli RamiR. Keith RaneyMatthias RaynalElisabeth RemyFrédérique RémyMarco RestanoAnnie RichardsonDonald RichardsonRobert RickerMartina RickoEero RinneStine Kildegaard RoseVinca RosmorducSergei RudenkoSimón RuizBarbara RyanCorinne SalaünAntonio Sanchez-RomanLouise Sandberg SørensenDavid SandwellMartin SaracenoMichele ScagliolaPhilippe SchaefferMartin ScharffenbergRemko ScharrooAndreas SchillerRaphael SchneiderChristian SchwatkeAndrea ScozzariEnrico Ser-GiacomiF. SeylerRashmi ShahRashmi SharmaAndrew ShawAndrew ShepherdJay ShriverC.K. ShumWim SimonsSebatian SimonsenThomas SlaterWalter SmithSaulo SoaresMikhail SokolovskiyLaurent SoudarinCiprian SpatarSabrina SpeichMargaret SrinivasanMeric SrokoszEmil StanevJoanna StanevaNathalie SteunouJulienne StroeveBob SuYohanes Budi SulistioadiDebadatta SwainAnnick Sylvestre-BaronNicolas TaburetRémi TailleuxKatsumi TakayamaByron TapleyAngelica TarpanelliGilles TavernierLaurent TestutPraveen ThakurPierre ThibautLuanne ThompsonJoaquín TintoréCéline TisonCédric TourainJean TournadreBill TownsendNgan TranSébastien TrillesMichel TsamadosKuo-Hsin TsengClément UbelmannBernd UebbingOscar VergaraJacques VerronTelmo VieiraStefano VignudelliNadya Vinogradova ShifferPieter VisserFrédéric VivierDenis VolkovKarina von SchuckmannValerii VuglinskiiPierrik VuilleumierBlake WalterJida WangChao WangChristopher WatsonJohn WilkinJosh WillisHilary WilsonPhilip WoodworthKehan YangFangfang YaoRaymond ZahariaElena ZakharovaEdward ZaronYongsheng ZhangZhongxiang ZhaoVadim ZinchenkoVictor Zlotnicki
• Organismes : European Centre for Medium-Range Weather Forecasts Soil Conservation and Watershed Management Research Institute Scripps Institution of Oceanography Space Applications Centre [Ahmedabad] Collecte Localisation Satellites National Space Institute [Lyngby] Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados Météo-France Direction Interrégionale Sud-Est Department of Earth and Environmental Sciences [Ann Arbor] Jet Propulsion Laboratory Variabilité de l'Océan et de la Glace de mer Mercator Océan Università degli Studi di Napoli “Parthenope” = University of Naples Laboratoire d'études en Géophysique et océanographie spatiales P.P. Shirshov Institute of Oceanology Department of Space and Climate Physics [UCL London] National Oceanography Centre Institute of Geodesy and Geophysics [Wuhan] Istituto di Ricerca per la Protezione Idrogeologica [Perugia] Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados Géoazur Space Applications Centre [Ahmedabad] DTU Environment, Department of Environmental Engineering Technische Universität Darmstadt - Technical University of Darmstadt [Darmstadt] Centre National d'Études Spatiales [Toulouse] St Petersburg State University Mercator Océan Agence Spatiale Algérienne = Algerian Space Agency Vanderbilt University [Nashville] European Space Research Institute Laboratoire d'études en Géophysique et océanographie spatiales Centre for Marine Technology and Ocean Engineering Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'études en Géophysique et océanographie spatiales Systèmes de Référence Temps Espace European Space Research and Technology Centre European Space Research Institute Centre National d'Études Spatiales [Toulouse] Ecole et Observatoire des Sciences de la Terre INSU Division Technique de l'INSU [Site de Brest] Institut des Géosciences de l’Environnement Queen's University [Kingston, Canada] Istituto di Ricerca per la Protezione Idrogeologica [Perugia] Department of Space and Climate Physics [UCL London] OceanNext Jet Propulsion Laboratory Centre National d'Études Spatiales [Toulouse] Géosciences Environnement Toulouse Institute of Oceanology, Polish Academy of Sciences Centre for Polar Observation and Modelling Australian Institute of Marine Science [Townsville] Laboratoire d'études en Géophysique et océanographie spatiales INSU Division Technique de l'INSU [Site de Brest] Istituto di Ricerca per la Protezione Idrogeologica [Perugia] NOVELTIS [Sté] Collecte Localisation Satellites Science Systems and Applications, Inc. [Hampton] Collecte Localisation Satellites Laboratoire d'études en Géophysique et océanographie spatiales International Space Science Institute [Bern] Center for Ocean-Atmospheric Prediction Studies Indian Institute of Remote Sensing Centre National d'Études Spatiales [Toulouse] Scripps Institution of Oceanography Centre National d'Études Spatiales [Toulouse] Istituto di Science Marine European Centre for Space Applications and Telecommunications Airbus Group [Germany] Institut des Géosciences de l’Environnement School of Earth Sciences [Columbus] Università degli Studi di Napoli “Parthenope” = University of Naples Satellite Oceanographic Consultants Ltd Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Laboratoire d'études en Géophysique et océanographie spatiales Centre National d'Études Spatiales [Toulouse] Northwest Atlantic Fisheries Centre Processus et interactions de fine échelle océanique Géosciences Environnement Toulouse Jet Propulsion Laboratory National Oceanography Centre Centre National d'Études Spatiales [Toulouse] School of Engineering [Callaghan] Jet Propulsion Laboratory Jet Propulsion Laboratory Deutsches Geodätisches Forschungsinstitut National Space Institute [Lyngby] SOCIB Balearic Islands Coastal Ocean Observing and Forecasting System Centre National d'Études Spatiales [Toulouse] Laboratoire d'études en Géophysique et océanographie spatiales Collecte Localisation Satellites German Research Centre for Geosciences - Helmholtz-Centre Potsdam Laboratoire d'Océanographie Physique et Spatiale Institut méditerranéen d'océanologie Department of Civil Chemical Environmental and Materials Engineering [Bologna] NOAA Office of Satellite and Product Operations NOAA Atlantic Oceanographic and Meteorological Laboratory European Space Research and Technology Centre INSU Division Technique de l'INSU [Site de Brest] European Space Research and Technology Centre Laboratoire d'études en Géophysique et océanographie spatiales Oregon State University German Research Centre for Geosciences - Helmholtz-Centre Potsdam Géosciences Environnement Toulouse IMT Atlantique Département Mathematical and Electrical Engineering Equipe Observations Signal & Environnement Université de Perpignan Via Domitia Department of Geographical Sciences [College Park] Collecte Localisation Satellites European Space Research Institute Institut für Geodäsie und Geoinformationstechnik Centro Interdisciplinar de Investigação Marinha e Ambiental = Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] Centro Interdisciplinar de Investigação Marinha e Ambiental = Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] Centre National d'Études Spatiales [Toulouse] Centro de Investigaciones del Mar y la Atmósfera INSU Division Technique de l'INSU [Site de Brest] Laboratoire d'études en Géophysique et océanographie spatiales National Space Institute [Lyngby] Laboratoire d'études en Géophysique et océanographie spatiales Collecte Localisation Satellites Department of Space and Climate Physics [UCL London] Department of Space and Climate Physics [UCL London] European Space Research and Technology Centre Institut des Géosciences de l’Environnement National Oceanography Centre Laboratoire d'études en Géophysique et océanographie spatiales Institut für Planetare Geodäsie, Lohrmann-Observatorium Centre National d'Études Spatiales [Toulouse] Universidad Nacional de Mar del Plata [Mar del Plata] Centre National d'Études Spatiales [Toulouse] Fisheries and Oceans Canada = Pêches et Océans Canada [Ottawa] SPACE - LATMOS NOVELTIS [Sté] DTU Environment, Department of Environmental Engineering Environmental Fluid Mechanics Laboratory [Daejeon] DTU Environment, Department of Environmental Engineering Ecole Normale Supérieure Paris-Saclay National Space Institute [Lyngby] German Research Centre for Geosciences - Helmholtz-Centre Potsdam P.P. Shirshov Institute of Oceanology Laboratoire d'études en Géophysique et océanographie spatiales Collecte Localisation Satellites Centre National d'Études Spatiales [Toulouse] Laboratoire d'études en Géophysique et océanographie spatiales Center for Ocean-Atmospheric Prediction Studies Centro Interdisciplinar de Investigação Marinha e Ambiental = Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] Centre National d'Études Spatiales [Toulouse] Institut des Géosciences de l’Environnement Laboratoire d'études en Géophysique et océanographie spatiales Processus et interactions de fine échelle océanique Laboratoire d'Océanographie Physique et Spatiale Laboratoire d'études en Géophysique et océanographie spatiales Centre National d'Études Spatiales [Toulouse] Laboratoire d'études en Géophysique et océanographie spatiales Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados European Space Research and Technology Centre Centre National d'Études Spatiales [Toulouse] Institut des Géosciences de l’Environnement Laboratoire d'études en Géophysique et océanographie spatiales Centre National d'Études Spatiales [Toulouse] Collecte Localisation Satellites Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'études en Géophysique et océanographie spatiales Centre National d'Études Spatiales [Toulouse] Collecte Localisation Satellites National Space Institute [Lyngby] Laboratoire d'études en Géophysique et océanographie spatiales Centro de Investigaciones del Mar y la Atmósfera Jet Propulsion Laboratory Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados Deutsches Geodätisches Forschungsinstitut Institut des Géosciences de l’Environnement School of Engineering [Callaghan] Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Collecte Localisation Satellites Centre for Marine Technology and Ocean Engineering Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Austral, Boréal et Carbone Collecte Localisation Satellites Laboratoire d'Océanographie Physique et Spatiale Laboratoire d'études en Géophysique et océanographie spatiales Jet Propulsion Laboratory National Space Institute [Lyngby] Collecte Localisation Satellites Deutsches Geodätisches Forschungsinstitut Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados Group on Earth Observations Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados National Space Institute [Lyngby] Collecte Localisation Satellites Deutsches Geodätisches Forschungsinstitut UMR 228 Espace-Dev, Espace pour le développement Jet Propulsion Laboratory National Space Institute [Lyngby] Collecte Localisation Satellites Jet Propulsion Laboratory National Oceanography Centre Centre National d'Études Spatiales [Toulouse] Centre for Polar Observation and Modelling Centre National d'Études Spatiales [Toulouse] Collecte Localisation Satellites Centre National d'Études Spatiales [Toulouse] Laboratoire d'études en Géophysique et océanographie spatiales Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Laboratoire d'Océanographie Physique et Spatiale Collecte Localisation Satellites Centre for Polar Observation and Modelling Laboratoire d'études en Géophysique et océanographie spatiales Institut des Géosciences de l’Environnement Centro Interdisciplinar de Investigação Marinha e Ambiental = Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] Processus et interactions de fine échelle océanique European Space Research and Technology Centre Kansas State University Kansas State University Université de Caroline du Nord à Chapel Hill = University of North Carolina [Chapel Hill] University of Tasmania [Hobart] Rutgers, The State University of New Jersey [New Brunswick] Institute of Arctic Alpine Research [University of Colorado Boulder] Water Problems Institute Portland State University [Portland] Applied Physics Laboratory [Seattle] Jet Propulsion Laboratory
• Publié dans Advances in Space Research le 26/10/2020

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Résumé : In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology.The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion.

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Fichiers liés : 1-s2.0-S0273117721000594-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Marie WislezCharlotte DomblidesLaurent GreillierJulien MazièresIsabelle MonnetLize Kiakouama-MalekaXavier QuantinJean Philippe SpanoCharles RicordelPhilippe FraisseHenri JanicotClarisse Audigier-ValetteElodie AmourAlexandra LanglaisNathalie RabbeAlain MakinsonJacques CadranelPierre Laurent-PuigArmelle LavoléHélène Blons
• Organismes : Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Lung Cancer le 27/10/2020

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Fichiers liés : Circulating tumor DNA in advanced non-small cell lung cancer patients with HIV.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Maxime GuéguinouRomain FelixSéverine Marionneau-LambotVincent PailléAubin PennaSana KoubaAudrey GambadeYann FourbonDavid TernantChristophe ArnoultGaëlle SimonAna Maria BouchetAurélie ChantômeThomas HarnoisJean-Pierre HaeltersPaul-Alain JaffrèsGunther WeberPhilippe BougnouxFrançois CarreauxOlivier MignenChristophe VandierMarie Potier-Cartereau
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-.2022] Niche, Nutrition, Cancer et métabolisme oxydatif Institut de Recherche en Santé de l'Université de Nantes The Enteric Nervous System in gut and brain disorders [U1235] Signalisation et Transports Ioniques Membranaires Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-.2022] Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-.2022] Université de Brest Chimie, Electrochimie Moléculaires et Chimie Analytique Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Signalisation et Transports Ioniques Membranaires Université de Brest Chimie, Electrochimie Moléculaires et Chimie Analytique Chimie, Electrochimie Moléculaires et Chimie Analytique Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Institut des Sciences Chimiques de Rennes Lymphocytes B, Autoimmunité et Immunothérapies Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif
• Publié dans Cell Calcium le 29/10/2020

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Résumé : The Transient Receptor Potential Vanilloid type 2 (TRPV2) channel is highly selective for Ca2+ and can be activated by lipids, such as LysoPhosphatidylCholine (LPC). LPC analogues, such as the synthetic alkyl-ether-lipid edelfosine or the endogenous alkyl-ether-lipid Platelet Activating Factor (PAF), modulates ion channels in cancer cells. This opens the way to develop alkyl-ether-lipids for the modulation of TRPV2 in cancer. Here, we investigated the role of 2-Acetamido-2-Deoxy-l-O-Hexadecyl-rac-Glycero-3-PhosphatidylCholine (AD-HGPC), a new alkyl-ether-lipid (LPC analogue), on TRPV2 trafficking and its impact on Ca2+ -dependent cell migration. The effect of AD-HGPC on the TRPV2 channel and tumour process was further investigated using calcium imaging and an in vivo mouse model. Using molecular and pharmacological approaches, we dissected the mechanism implicated in alkyl-ether-lipids sensitive TRPV2 trafficking. We found that TRPV2 promotes constitutive Ca2+ entry, leading to migration of highly metastatic breast cancer cell lines through the PI3K/Akt-Girdin axis. AD-HGPC addresses the functional TRPV2 channel in the plasma membrane through Golgi stimulation and PI3K/Akt/Rac-dependent cytoskeletal reorganization, leading to constitutive Ca2+ entry and breast cancer cell migration (without affecting the development of metastasis), in a mouse model. We describe, for the first time, the biological role of a new alkyl-ether-lipid on TRPV2 channel trafficking in breast cancer cells and highlight the potential modulation of TRPV2 by alkyl-ether-lipids as a novel avenue for research in the treatment of metastatic cancer.

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Fichiers liés : Gueguinou_et al_2021_Synthetic Alkyl-Ether-lipid promotes TRPV2 Channel_accepted.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Noémie CrestoCamille GardierMarie-Claude GaillardFrancesco GubinelliPauline RoostDaniela MolinaCharlène JosephineNoëlle DufourGwenaëlle AureganMartine GuillermierSuéva BernierCaroline JanPauline GipchteinPhilippe HantrayeMarie-Christine Chartier-HarlinGilles BonventoNadja Van CampJean-Marc TaymansKarine CambonGéraldine LiotAlexis-Pierre BemelmansEmmanuel Brouillet
• Organismes : Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Lille Neurosciences & Cognition - U 1172 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Lille Neurosciences & Cognition - U 1172 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199 Laboratoire des Maladies Neurodégénératives - UMR 9199
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson’s disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the C-terminal portion of LRRK2 (ΔLRRK2) with the G2019S mutation (ΔLRRK2G2019S) was sufficient to induce neurodegeneration of DA neurons in vivo, suggesting that mutated LRRK2 induces neurotoxicity through mechanisms that are (i) independent of the N-terminal domains and (ii) “cell-autonomous”. Here, we explored whether ΔLRRK2G2019S could modify α-syn toxicity through these two mechanisms. We used a co-transduction approach in rats with AAV vectors encoding ΔLRRK2G2019S or its “dead” kinase form, ΔLRRK2DK, and human α-syn with the A53T mutation (AAV-α-synA53T). Behavioral and histological evaluations were performed at 6- and 15-weeks post-injection. Results showed that neither form of ΔLRRK2 alone induced the degeneration of neurons at these post-injection time points. By contrast, injection of AAV-α-synA53T alone resulted in motor signs and degeneration of DA neurons. Co-injection of AAV-α-synA53T with AAV-ΔLRRK2G2019S induced DA neuron degeneration that was significantly higher than that induced by AAV-α-synA53T alone or with AAV-ΔLRRK2DK. Thus, mutated α-syn neurotoxicity can be enhanced by the C-terminal domain of LRRK2G2019 alone, through cell-autonomous mechanisms.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Marie WislezCharlotte DomblidesLaurent GreillierJulien MazièresIsabelle MonnetLize Kiakouama-MalekaXavier QuantinJean Philippe SpanoCharles RicordelPhilippe FraisseHenri JanicotClarisse Audigier-ValetteElodie AmourAlexandra LanglaisNathalie RabbeAlain MakinsonJacques CadranelPierre Laurent-PuigArmelle LavoléHélène Blons
• Organismes : Hôpital Cochin [AP-HP] Centre de Recherche des Cordeliers Centre Hospitalier Universitaire de Bordeaux Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique Centre Hospitalier Universitaire de Toulouse Service de Pneumologie [CHI Créteil] Hôpital de la Croix-Rousse [CHU - HCL] Institut régional de Cancérologie de Montpellier CHU Pitié-Salpêtrière [AP-HP] Service de pneumologie [Rennes] = Pneumology [Rennes] Nouvel Hôpital Civil de Strasbourg Service Pneumologie / Allergologie [CHU Clermont-Ferrand] Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse Intergroupe Francophone de Cancérologie Thoracique [Paris] Intergroupe Francophone de Cancérologie Thoracique [Paris] Hôpital Cochin [AP-HP] Centre de Recherche des Cordeliers CHU Montpellier = Montpellier University Hospital Assistance publique - Hôpitaux de Paris (AP-HP) Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules Centre de Recherche des Cordeliers Assistance publique - Hôpitaux de Paris (AP-HP) Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules Assistance publique - Hôpitaux de Paris (AP-HP) Centre de Recherche des Cordeliers Assistance publique - Hôpitaux de Paris (AP-HP)
• Publié dans Lung Cancer le 27/10/2020

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Résumé : Introduction HIV is an exclusion criterion for most lung cancer (LC) trials, however LC is the most common non-AIDS-defined malignancy in people living with HIV (PLHIV), poorer prognosis than the general population. Circulating tumor DNA (ctDNA) was a prognostic marker in LC patients from the general population. This study assessed ctDNA’s prognostic value in PLHIV from a dedicated phase II trial. Methods Overall, 61 PLHIV with advanced non-squamous non-small-cell lung cancer (NSCLC) participated in the IFCT Phase II trial evaluating first-line four-cycle carboplatin (Ca) AUC5 pemetrexed (P) 500 mg/m2 induction therapy every 3 weeks, followed by P maintenance therapy. Blood samples collected before treatment were analyzed to detect ctDNA using ultra-deep targeted next-generation-sequencing (NGS). Results Appropriate samples were available from 55 PLVIH and analyzed for ctDNA detection. Including 42 males (76.4 %), 52.9 years median age, 51 smokers (92.7 %), five with non-squamous NSCLC Stage III (9%), 50 Stage IV (91 %), and performance status (PS) 0−2. ctDNA was detected in 35 patients (64 %), 22 with high and 13 with low ctDNA levels. Overall, 77 % were positive for TP53, 29 % for KRAS, and 11 % for STK11 mutations, more than one alteration was detected in 43 % of samples. Multivariate analysis showed that positive ctDNA was significantly associated with shorter PFS (HR, 4.31, 95 %CI: 2.06−8.99, p < 0.0001), and shorter OS (HR, 3.52, 95 %CI: 1.72−7.19, p < 0.001). Moreover, OS was significantly longer for patients with low ctDNA levels at diagnosis as compared to high (p = 0.01). Conclusion We show that ctDNA detection using ultra-deep NGS is an independent prognostic factor in PLHIV with advanced NSCLC.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Jean-Philippe Garric
• Organismes : Histoire culturelle et sociale de l'art
• Publié dans Lettre des Amis du Musée Louis-Philippe du Château d’Eu et du Domaine royam de Randan le 18/11/2022

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Mathilde MalingeFanny GrimaudJean-Philippe PerrinJustine LoinMarine AnquetilJacques MercierPierre CorreHélios Bertin
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Clinique Jules-Vernes [Nantes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Regenerative Medicine and Skeleton Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238]
• Publié dans Journal of Stomatology, Oral and Maxillofacial Surgery le 25/10/2020

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Résumé : Introduction: The treatment of fractures of the mandibular condylar process remains controversial, especially in children. The aim of this study was to assess the long-term clinical and radiographic outcomes of functional treatments for mandibular condylar fractures with an articular impact. Materials and methods: Young patients (< 15 years of age) presenting with either a unilateral or a bilateral mandibular fracture of the condylar process were included in this retrospective study. The clinical analysis focused on investigation of joint amplitudes at 1, 2, 6, 12, and 24 months after the beginning of the treatment, and at the end of their physical growth for the long-term study. Other clinical parameters included temporomandibular joint (TMJ) disorders and facial asymmetry. Photographs of patients and panoramic X-rays were assessed to identify any growth disorders at the end of the follow-up. Results: One hundred and eight patients were included in this study, and 33 patients who were no longer undergoing mandibular growth at the time of the last follow-up were included in the long-term study. The mean age at the time of the trauma was 9.33 years, and the mean follow-up was 82.2 months. A significant improvement was observed in the maximal mouth opening (MMO), diduction, and propulsion in the first months after the trauma, reaching 44.31 mm (p < 0.0001), 10.50 mm (p=0.0001), and 6.33 mm (p=0.01), respectively, at 6 months. Three patients experienced a clinical posterior vertical insufficiency, one of which required a surgical procedure, while four patients exhibited a ramus asymmetry of up to 10 mm, albeit with no clinical consequences. One case of TMJ ankylosis was noted. Conclusion: Our study suggests that functional treatment is appropriate for fractures of the mandibular condyle with an articular impact in children, as it promotes mandibular growth and good functional recovery. Children have to be followed up, however, until completion of growth.

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Fichiers liés : 1-s2.0-S2468785521001427-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2021
• Auteurs : Paul SaultierYves GuillaumeVirginie DemiguelClaire BergerAnnie Borel-DerlonSégolène ClaeyssensAnnie HarrocheCaroline OudotAnne RafowiczMarc TrossaertBénédicte WibautChristine VinciguerraMohamed BoucekineKarine BaumstarckSandrine MeunierThierry CalvezHervé ChambostAchille AoubaAnnie HarrocheFaezeh LegrandChantal RothschildMarie-Françoise TorchetRoseline D’oironThierry LambertYves LaurianAnne RafowiczJennifer BiernatJenny GoudemandArmelle ParquetVéronique TintillierBénédicte WibautAnne Durin AssollantSandrine MeunierClaude NégrierSabine CastetViviane GuérinYohann HugueninMarguerite MicheauAnne RymanHérve ChambostCéline FalaiseSégolène ClaeyssensMarie Françoise Thiercelin-LegrandMarianne Fiks-SigaudMarc FouassierEdith FressinaudMarc TrossaertSophie VoisinAlbert FaradjiPatrick LutzMarie Elisabeth BriquelBirgit FrotscherBéatrice FimbelYves GruelClaude GueroisSandra ReginaJean Baptiste ValentinChristine Biron AndreaniPhilippe CodineDaniel DonadioRobert NavarroPaola RospideJean-François SchvedClaire BergerBénédicte ColletAnnie Borel-DerlonPhilippe GautierSophie BayartJeanne-Yvonne BorgCécile DumesnilCharline NormandPascale SchneiderPhilippe TronJean-Pierre VannierFabienne DutrillauxFabienne VolotPiotr GembaraAlain Marques-VerdierDalila AdjaoudClaire BarroGilles PernodPatricia PouzolNadra OunnoughenePatricia PaugyValérie RobertNatalie StieltjesBrigitte BastenaireEmmanuelle de RaucourtJocelyne PeynetAnne RafowiczValérie Li-Thiao-TeBrigitte PautardCatherine BeharStéphanie GordeMartine MunzerValérie GayElisabeth Benz LemoineLaurent MacchiLionel de LumleySolange GaillardCaroline OudotAnne DevilleFabrice MonpouxMarie Anne BertrandBrigitte Pan-PeteschAbel HassounBrigitte CoatmelecPhilippe BeurrierMichèle DamayPhilippe MoreauOdile Pouille-LievinCaroline SchoepferEliane TarralMonique BianchinJoël NguyenOlivier PincemailleMarie-Odile Peter
• Organismes : Assistance Publique - Hôpitaux de Marseille
• Publié dans The Journal of Pediatrics le 25/10/2020

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Fichiers liés : SAULTIER JPEDS.pdf

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