Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Rémi LetestuAbdelmalek DahmaniMarouane BoubayaLucile BaseggioLydia CamposBernard ChatelainAgathe DebliquisBernard DrénouMarie-Christine JacobEric LegacMagali Le Garff-TavernierAnne-Catherine LhoumeauClaire QuineyNelly RobillardMichel TicchioniCarmen AaneiSandrine KatsahianRoselyne DelepineSandrine VaudauxValérie RouilléMarie-Christine BénéCaroline DartigeasEric van den NesteStéphane LeprêtrePierre FeugierGuillaume CartronVéronique LeblondVincent LévyFlorence CymbalistaSylvie CailleresGandhi DamajBruno RoyerMartine GardembasMamoun DibMatgorzata Truchan-GraczykMathilde Hunault-BergerCharles FoussardBernadette CorrontAnne ParryFrédérique Orsini-PiocelleSébastien TrouillierBohiane SlamaGérard LepeuHacene ZerazhiOlivier BoulatAhmed AzzedineCarla AraujoAnne BanosFrédéric BauduerJean-Luc DutelKamel GhomariEric DeconinckAnnie BrionJacqueline VuillierAlain SaadAbderrazak El YamaniPhilippe RodonPierre SoubeyranGabriel EtienneMarie-Sarah DilhuydyKrimo BouabdallahThibaut LeguayBachra ChouffiBertrand PolletAbdallah MaakarounGaëlle GuillermChristian BerthouNathalie CheronMarc AndréJean Pierre VilqueChristophe FruchartLaurent VoillatGian Matteo PicaSélim CormJean-Michel MicléaBertrand SouleauCécile Molucon-ChabrotBenoit de RenzisOlivier TournilhacJacques-Olivier BayCarine ChaleteixRomain GuiezeJoel FleuryCristina PrecupanuSelwa BouledrouaStéphanie HaiatCharlotte PetitdidierJehan DupuisKarim BelhadjOlivier CasasnovasJean-Noel BastieEmmanuelle FerrantDany GholamLysiane MolinaFrédéric GarbanMourad TiabHervé MaisonneuveBruno VillemagneDominique JacomyCaroline BessonGérard TertianKamel LaribiPierre MorelBruno CazinStéphane MoreauLiliane ReminierasMarie-José RappPhilippe MoreauCatherine SebbanAnne-Sophie MichalletGilles André SallesFlorence BroussaisThérèse Aurran-SchleinitzDiane CosoWajed AbarahClaire KulekciVéronique DorvauxPhilippe CarassouIsabelle GuibaudBernard ChristianCarlos GrauxJean-François RossiPhilippe QuittetAlain DuboisJean-Claude EisenmannNadine MorineauBéatrice MahéJean-Michel KarsentiEric JourdanÉric LegouffeMagda Alexis-VigierJean-Michel BouletMalek AoudjhaneCatherine ThiéblemontAnna Lisa AndreoliFrançois DreyfusSylvain ChoquetKarim MaloumHélène Merle-BéralAnne VekhoffDidier DecaudinPhilippe BraultRichard DelarueMaud JanvierCarole SoussainXavier VallantinLaurence SanhesBrigitte DreyfusCécile TomowiakRiad BenramdaneHugo GonzalezAnne Blaise-BrennaBrigitte KolbAlain DelmerCharles DauriacRoch HouotMartine Escoffre-BarbeThierry LamySophie de GuibertMarc BernardBernard GrosboisOana BreharPatrick MoriceDenis GuyotatJérome JaubertChristelle PortoisLuc-Matthieu ForneckerRaoul HerbrechtKarin BilgerShanti AmeLoic YsebaertPascal GodmerHenry Jardel
• Organismes : Hôpital Avicenne [AP-HP] Signalisation, Microenvironnement et Hémopathies Lymphoïdes B Hôpital Avicenne [AP-HP] Hôpital Avicenne [AP-HP] Centre Hospitalier Lyon Sud [CHU - HCL] Immuno-Biologie des Lymphomes [CIRI] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] CHU UCL Namur Groupe hospitalier de la région de Mulhouse Sud-Alsace Groupe hospitalier de la région de Mulhouse Sud-Alsace Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Regional d'Orléans CHU Pitié-Salpêtrière [AP-HP] Institut Paoli-Calmettes CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hopital Saint-Louis [AP-HP] Centre Hospitalier Régional Universitaire de Tours Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire de Tours Université Catholique de Louvain = Catholic University of Louvain Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier CHU Pitié-Salpêtrière [AP-HP] Hôpital Avicenne [AP-HP] Hôpital Avicenne [AP-HP] Lymphocytes B, Autoimmunité et Immunothérapies
• Publié dans Leukemia le 25/10/2020

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Résumé : Measurable residual disease (MRD) status is widely adopted in clinical trials in patients with chronic lymphocytic leukemia (CLL). Findings from FILO group trials (CLL2007FMP, CLL2007SA, CLL2010FMP) enabled investigation of the prognostic value of high-sensitivity (0.7 × 10-5) MRD assessment using flow cytometry, in blood (N = 401) and bone marrow (N = 339), after fludarabine, cyclophosphamide, and rituximab (FCR)-based chemoimmunotherapy in a homogeneous population with long follow-up (median 49.5 months). Addition of low-level positive MRD < 0.01% to MRD ≥ 0.01% increased the proportion of cases with positive MRD in blood by 39% and in bone marrow by 27%. Compared to low-level positive MRD < 0.01%, undetectable MRD was associated with significantly longer progression-free survival (PFS) when using blood (72.2 versus 42.7 months; hazard ratio 0.40, p = 0.0003), but not when using bone marrow. Upon further stratification, positive blood MRD at any level, compared to undetectable blood MRD, was associated with shorter PFS irrespective of clinical complete or partial remission, and a lower 5-year PFS rate irrespective of IGHV-mutated or -unmutated status (all p < 0.05). In conclusion, high-sensitivity (0.0007%) MRD assessment in blood yielded additional prognostic information beyond the current standard sensitivity (0.01%). Our approach provides a model for future determination of the optimal MRD investigative strategy for any regimen.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Jean-Guillaume LetarouillyBenoît FlachaireCéline LabadieMaéva KyhengNicolas CohenJérémie SellamP. RichettePhilippe DieudePascal ClaudepierreBruno FautrelEric HouvenagelChi Duc NguyenMarie-Hélène GuyotNicolas SegaudLaurent MarguerieXavier DeprezJean-Hugues SalmonGuy BaudensCorinne Miceli-RichardElisabeth Solau-GervaisIsabelle Chary-ValckenaerePierre LafforguePeggy PhilippeDamien LoeuilleChristophe RichezFlorence TubachThao PhamRené-Marc Flipo
• Organismes : Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Aix Marseille Université Université de Bordeaux Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Aix Marseille Université Centre de Recherche Saint-Antoine Biologie de l'Os et du Cartilage : Régulations et Ciblages Thérapeutiques Physiopathologie et Epidémiologie des Maladies Respiratoires Epidemiology in Dermatology and Evaluation in Therapeutics Sorbonne Université Institut Catholique de Lille Université de Reims Champagne-Ardenne Université Paris Cité Université de Poitiers = University of Poitiers Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Ingénierie Moléculaire et Physiopathologie Articulaire Service de Rhumatologie [CHRU Nancy] Institut des Sciences du Mouvement Etienne Jules Marey Centre Hospitalier Régional Universitaire [CHU Lille] Université de Poitiers = University of Poitiers Université de Bordeaux Institut Pierre Louis d'Epidémiologie et de Santé Publique Aix Marseille Université Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Rheumatology le 29/10/2020

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Résumé : Objectives: To evaluate the characteristics of patients (pts) with PsA treated by ustekinumab (UST) or secukinumab (SEK) and to compare real-world persistence of UST and SEK in PsA.Methods: In this retrospective, national, multicentre cohort study, pts with PsA (CASPAR criteria or diagnosis confirmed by the rheumatologist) initiating UST or SEK with a follow-up ≥6 months were included from January 2011 to April 2019. The persistence between SEK and UST was assessed after considering the potential confounding factors by using pre-specified propensity-score methods. Causes of discontinuation and tolerance were also collected.Results: A total of 406 pts were included: 245 with UST and 161 with SEK. The persistence rate was lower in the UST group compared with the SEK group [median persistence 9.4 vs 14.7 months; 26.4% vs 38.0% at 2 years; weighted hazard ratio (HR) = 1.42; 95% CI: 1.07, 1.92; P =0.015]. In subgroup analysis, the persistence rate of SEK associated with MTX was significantly higher than that of UST associated with MTX: HR = 2.20; 95% CI: 1.30, 3.51; P =0.001, in contrast to SEK vs UST monotherapy: HR = 1.06; 95% CI: 0.74, 1.53; P =0.75. Discontinuation due to inefficacy was reported in 91.7% (SEK) and 82.4% (UST) of pts. Discontinuation due to an adverse event was reported in 12.2% (SEK) and 7.7% (UST) of pts.Conclusion: In this first study comparing UST and SEK, the persistence of SEK was higher than that of UST in PsA. In subgroup analysis, this difference was only found in association with MTX.

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Fichiers liés : article 15_hal.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Nicola DismaFrancis VeyckemansKatalin ViragTom HansenKarin BeckePierre HarletLaszlo VutskitsSuellen WalkerJurgen de GraaffMarzena ZielinskaDusica SimicThomas EngelhardtWalid HabreChristian BreschanRudolf LikarManuela PlatzerIsole EdelmanJohanes EgerStefan HeschlBrigitte MessererMaria VittinghofRuth KroessMartina StichlbergerDavid KahnThierry PirotteCaroline PregardienFrance StevensJohan BerghmansAnnemie BautersLuc de BaerdemaekerStefan de HertKoen LapageAliaksandra ParashchankaJurgen van LimmenPiet WyffelsJulie LauwerynsNadia NajafiJoris VundelinckxDiana ButkovićIvana Kerovec SorićSandra KralikAna MarkićJosip AzmanJosko MarkicDaniela PupacicMichal FrelichPetr ReimerRene UrbanecPetra CajkovaVladimir MixaYvona SedlačkovaLenka KnoppovaAlena Zlamalova (nee Květoňova)Martin VavřinaJiři ŽurekArash AfshariAnders BilleMarguerite EllekvistMari-Liis IlmojaReet MoorReet KikasMerle ValiKariantti KallioElisa ReponenPertti SuominenSami SuvantoRaisa VahataloHannu KokkiMerja KokkiJarkko HarjuMiia KokkonenJenni VieriTuula MannerCatherine AmoryHugues LudotDina BertJuliette GodartAnne LaffargueHervé DupontBenjamin UrbinaCatherine BaujardPhilippe RoulleauGiuseppe StaitiMaryline BordesKarine Nouette GaulainYann HamonicFrancois SemjenOlivier JacqmarcqCaroline Lejus-BourdeauCecile MagneLea PetryLilica RosAurelien ZangMehdi BennisBernard CoustetsRose FesseauIsabelle ConstantEliane KhalilNada SabourdinNoemie AudrenThomas DescarpentriesFanny FabreAurelien LegrandEmilie DruotGilles OrliaguetLucie SabauLynn UhrigFrancois de La BriereKarin JonckheerJean-Paul MissionLucia ScordoCaroline CouchepinChristophe DadurePablo de La ArenaLaurent HertzPhilippe PiratChrystelle SolaMyriam BellonSouhayl DahmaniFlorence Julien-MarsollierDaphne MicheletVeronique Depret-DonatienAnne LesageJost KaufmannMichael LaschatFrank WapplerLena BrunnerKarin OppenriederGregor BadeltKarin HochmuthBernhard KollerAnita ReilSebastian RichterThomas FischerAnja DiersClemens SchorerAndreas WeylandRuth CohauszFranz-Josef KretzMichaela LofflerMarkus WilbsClaudia HoehneJohanna UlriciChristiane GoetersArmin FlinspachMatthias KlagesSimone LindauLeila MessroghliKai ZacharowskiChristoph EisnerThomas D MuellerDaniel RichterMelanie SchaferMarkus WeigandSebastian WeitererMiriam OchsenreiterMichael ScholerTom TerbovenIsabel EggemannSascha HaussmannNicolas LeisterChristoph MenzelUwe TrieschmannSirin YucetepeSusanna KeiligPeter KrankeYvonne JeltingTorsten BaehnerRichard EllerkmannShahab GhamariClaudia NeumannMartin SohlePelagia ChloropoulouVagia NtritsouPinelopi PapagiannopoulouEleana GariniAfroditi KarafotiaPanagoula MammiEvangelia BaliDespoina IordanidouAnna MalisiovaArtemis PolyzoiAdelais TsiotouErzsebet SapiEdgar SzekelyNandor KosikVeronika MaracziJanos SchnurJudit CsillagJanos GalGergely GoblBalazs HauserAndras PetroczyGyula TovishaziStuart BlainSarah GallagherSinead HarteMandy JacksonEmma MeehanZeenat NawoorBrendan O’hareMark RossDaniela LerroMarinella AstutoChiara GrassoRita ScalisiGiulia FrasaccoElena LenaresRoberto LeoneMaurizia GrazziniCarmelo MinardiNicola ZadraGilda CinnellaAntonella CotoiaDario GalanteBrita de LorenzoBeate KuppersGiulia BottazziFabio CaramelliMaria MondardiniEmanuele RossettiSergio PicardoAlessandro VittoriAnna CamporesiAndrea WolflerEdoardo CalderiniLaura ColantonioSimona FinamoreGiuliana PorroRachele BonfiglioSvetlana KotzevaLeila MameliGirolamo MattioliCamilla MicalizziAlessia MontagutiAngela PistorioClelia ZanaboniAnna GuddoGerald NebaMoreno FavaratoBruno LocatelliMicol MaffiolettiValter SonzogniRossella GarraMaria SammartinoFabio SbaragliaAndrea CortegianiAlessandra MoscarelliElena AttanasiSimonetta TesoroCristina AgapitiFrancesca PinzoniCesare VezzoliFederico BilottaArta BarzdinaZane StraumeAnda ZundaneLaura LukosieneIrena MaraulaiteIlona RazleviceBernd SchmitzStephanie MifsudCarolin AehlingCelia AllisonRients de BoerDina EmalMarkus StevensMarielle BuitenhuisInge de LiefdeAndreas MachottaGail ScoonesLonneke StaalsJeremy TomasAnouk van DerKnijff-Van DortmontMarianne VeldhuizenDavid AldersWolfgang BuhreEva SchafratJan SchreiberPetronella VermeulenMark HendriksSandra LakoMarieke Voet-LindnerBarbe PietersGert-Jan SchefferLuc TielensAnthony AbsalomMargot BergsmaJoke de RuiterSascha MeierMartin VolkersTjerk ZweersAnne BeukersChrista BoerJurgen DertingerSandra NumanBas van ZaaneWenche BoerkeNil EkizKristoffer StensrudInger DrageErik IsernAlicja Bartkowska-SniatkowskaMalgorzata GrzeskowiakMagdalena Juzwa-SobierajJowita Rosada-KurasińskaArtur BaranowskiKarina JakubowskaDorota LewandowskaMagdalena Mierzewska-SchmidtPiotr SawickiMagdalena Urban-LechowiczPomianek PrzemyslawTeresa LealMaria SoaresPedro PinaSilvia PinhoMaria Domingas PatuleiaCatarina EstevesHelena SalgadoMaria SantosRodica BadetiIulia CindeaLoredana OanaAdriana GuritaLuminita IlieGabriel MocioiuRadu TabacaruIrina TranteValentin MunteanuMihai MorariuEmese NyiriIvana BudicVesna MarjanovicBiljana DraškovićMarina PandurovJordanka IlicAna MandrasZdenka RadosNikola StankovicMaja SuicaSladjana VasiljevicMirjana KnezevicIrina MilojevicIvana PetrovSelena Puric RacicIrena SimicMarija StevicIrena VulicevicBarbora CabanovaMiloslav HanulaJelena BergerDarja JanjatovicŠpela ŠtupnikIvan KohnUlf LindestamJarl ReinhardAlbert CastellheimKerstin SandstromSporre BengtRainer DorenbergPeter FrykholmMaria GarciaAnn KvarnstromEmma PontenThomas BruelisauerGabor ErdoesHeiko KaiserMathias MarchonThomas RivaStefan SeilerYann BogliMirko DolciCarine MarcucciIsabelle PichonMattias CasuttMartin HolzleThomas HurniMartin JohrAnna UrsinaJacqueline Mauch MalarThomas ErbKarin OeinckMine AkinGulsen KeskinYesim SenayliGuner KayaPinar KendigelenAyse TutuncuZehra HatipoğluDilek OzcengizHale Aksu ErdostElvan OcmenCimen OlgunerHilmi AyanogluPelin DincerTumay UmurogluMustafa AzizogluHandan BirbicerNurcan DorukAsli SagunSibel BarisDmytro DmytriievSridevi KuchiNuria MasipPeter BrooksAlison HareNargis AhmadMichelle CaseySam de SilvaNadine DobbyPrakash KrishnanL. Amaki SogbodjorEllie WalkerStephanie KingKaty NicholsonMichelle QuinneyPaul StevensAndrew BlevinMariangela GiombiniChulananda GoonasekeraSadia AdilStephanie BewCarol BodlaniDan GilpinStephanie JinksNalini MalarkkanAlice MiskovicRebecca PadJuliet BarryJoy AbbottJames ArmstrongNatalie CooperLindsay CrateJohn EmeryKathryn JamesHannah KingPaul MartinStefano CatenacciRob BomontPaul SmithSara MeleAlessandra VerzelloniPhilippa DixGraham BellElena GordevaLesley MckeeEsther NganJutta ScheffczikLi-En TanMark WorrallCarmel CassarKevin GoddardVictoria BarlowVimmi OshanKhairi ShahSarah BellLisa DanielsMonica GandhiDavid PachterChris PerryAndrew RobertsonCarmen ScottLynne WaringDavid BarnesSophie ChildsJoanne NormanRobin Sunderland
• Organismes : Istituto Giannina Gaslini, Genova Centre Hospitalier Régional Universitaire [CHU Lille] University of Szeged [Szeged] Odense University Hospital Geneva University Hospitals and Geneva University Great Ormond Street Hospital for Children [London] Eramus MC-Sophia Children’s Hospital University of Wrocław [Poland] = Uniwersytet Wrocławski [Polska] = Universität Breslau [Polen] = Université de Wrocław [Pologne] University of Belgrade [Belgrade] Montreal Children's Hospital Geneva University Hospitals and Geneva University Klinikum Klagenfurt am Wörthersee Klinikum Klagenfurt am Wörthersee Klinikum Klagenfurt am Wörthersee Klinikum Klagenfurt am Wörthersee Medical University of Graz = Medizinische Universität Graz Medical University of Graz = Medizinische Universität Graz Medical University of Graz = Medizinische Universität Graz Medical University of Graz = Medizinische Universität Graz Medical University of Graz = Medizinische Universität Graz Innsbruck Medical University = Medizinische Universität Innsbruck Cliniques universitaires St Luc [Bruxelles] Cliniques universitaires St Luc [Bruxelles] Cliniques universitaires St Luc [Bruxelles] Ghent University Hospital Ghent University Hospital Ghent University Hospital Ghent University Hospital Ghent University Hospital Ghent University Hospital Ghent University Hospital Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Amiens-Picardie CHU Amiens-Picardie Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Hôpital Trousseau Hôpital Trousseau Hôpital Trousseau Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Hôpitaux Pédiatriques de Nice Lenval Hôpitaux Pédiatriques de Nice Lenval Hôpitaux Pédiatriques de Nice Lenval Hôpitaux Pédiatriques de Nice Lenval Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Robert Debré Paris Hôpital Robert Debré Paris Hôpital Robert Debré Paris Hôpital Robert Debré Paris CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie
• Publié dans British Journal of Anaesthesia le 28/10/2020

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Résumé : Background: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown. Methods: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical events. Results: Infants (n=5609) born at mean (standard deviation [sd]) 36.2 (4.4) weeks postmenstrual age (35.7% preterm) underwent 6542 procedures within 63 (48) days of birth. Critical event(s) requiring intervention occurred in 35.2% of cases, mainly hypotension (>30% decrease in blood pressure) or reduced oxygenation (SpO2 <85%). Postmenstrual age influenced the incidence and thresholds for intervention. Risk of critical events was increased by prior neonatal medical conditions, congenital anomalies, or both (relative risk [RR]=1.16; 95% confidence interval [CI], 1.04-1.28) and in those requiring preoperative intensive support (RR=1.27; 95% CI, 1.15-1.41). Additional complications occurred in 16.3% of patients by 30 days, and overall 90-day mortality was 3.2% (95% CI, 2.7-3.7%). Co-occurrence of intraoperative hypotension, hypoxaemia, and anaemia was associated with increased risk of morbidity (RR=3.56; 95% CI, 1.64-7.71) and mortality (RR=19.80; 95% CI, 5.87-66.7). Conclusions: Variability in physiological thresholds that triggered an intervention, and the impact of poor tissue oxygenation on patient's outcome, highlight the need for more standardised perioperative management guidelines for neonates and infants.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Jean BousquetOliver PfaarIoana AgacheAnna BedbrookCezmi A AkdisG Walter CanonicaTomás ChivatoMona Al‐ahmadAmir Abdul LatiffIgnacio Javier Ansotegui-ZubeldiaClaus BachertAbdullah BaharuddinKarl‐christian BergmannCarsten Bindslev‐jensenLeif BjermerMatteo BoniniSinthia Bosnic‐anticevichIsabelle BosseHelen Annaruth BroughLuisa BrussinoMoises CalderonLuis CaraballoVictoria CardonaPedro Carreiro‐martinsTomas CasaleLorenzo CecchiAlfonso Cepeda SarabiaEkaterine ChkhartishviliDerek ChuIeva CiruleAlvaro A. CruzWienczyslawa CzarlewskiStefano GiaccoPascal DemolyPhilippe DevillierDejan DokicStephen DurhamMotohiro EbisawaYehia El‐gamal✝Regina EmuzyteAmiran GamkrelidzeJean-Luc FauquertAlessandro Giovanni FiocchiWytske J. FokkensJoão Almeida FonsecaJean‐françois FontaineRadoslaw GawlikAslı GelincikBilun GemiciogluJose GeredaRoy Gerth van WijkR Maximiliano GomezMaia GotuaIneta GrisleMaria‐antonieta GuzmánTari HaahtelaSusanne HalkenEnrico HefflerKarin Hoffmann‐sommergruberElham HossnyMartin HrubiškoCarla IraniJuan Carlos IvancevichZhanat IspayevaKaja JulgeIgor KaidashevOmer KalayciMusa KhaitovLudger KlimekEdward KnolMarek KowalskiHelga KraxnerInger KullP. KunaVioleta KvedarieneVicky KritikosAntti LauermaSusanne LauDaniel LauneMichael LevinDesiree Larenas‐linnemannKarin Lodrup CarlsenCarlo LombardiOlga M. LourençoBassam MahboubHans‐jørgen MallingPatrick ManningGailen MarshallErik MelénEli MeltzerNeven MiculinicBranislava MilenkovicMostafa MoinStephen MontefortMário Morais‐almeidaCharlotte MortzRalph MösgesJ. MullolLeyla Namazova BaranovaHugo NeffenKristof NekamMarek NiedoszytkoMikaëla OdemyrRobyn O'HehirMarkus OllertLiam O’mahonyKen OhtaYoshitaka OkamotoKimi OkuboGiovanni PajnoOscar PalomaresSusanna PalkonenPetr PanznerNikolaos G. PapadopoulosHae‐sim ParkGiovanni PassalacquaVincenzo PatellaRuby PawankarNhân Pham‐thiDavor PlavecTodor PopovMarysia RectoFrederico RegateiroCarmen RiggioniGraham RobertsMonica Rodriguez‐gonzalesNelson RosarioMenachem RottemPhilip W. RouadiDermot RyanBoleslaw SamolinskiMario Sanchez‐borges✝Faradiba SerpaJoaquin SastreGlenis ScaddingManuel Soto‐quirosPeter Schmid‐grendelmeierHolger SchünemannAziz SheikhNicola ScichiloneJuan SisulMikhail SofievDirceu SoléTalant SooronbaevManuel Soto‐martinezManuel Soto‐quirosMilan SovaJürgen SchwarzeIsabel SkypalaCharlotte Suppli‐ulrikLuis Taborda‐barataAna Todo‐bomMaría José TorresMarylin Valentin‐rostanPeter‐valentin TomazicAntonio ValeroSanna Katriina Toppila-SalmiIoanna TsiligianniEva UntersmayrMarilyn Urrutia‐pereiraArunas ValiulisErkka ValovirtaOlivier VandenplasMaria VenturaPakit VichyanondMartin WagenmannDana WallaceJolanta Walusiak‐skorupaD. WangSusan WasermanGary WongArzu YorganciogluOsman YusufMario ZernottiLuo ZhangMihaela ZidarnTorsten ZuberbierMarek Jutel
• Organismes : Charité - UniversitätsMedizin = Berlin University Medicine Centre Hospitalier Régional Universitaire [Montpellier] Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon Philipps Universität Marburg = Philipps University of Marburg Transilvania University of Brasov Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon Universität Zürich [Zürich] = University of Zurich Humanitas University [Milan] Universidad San Pablo CEU Kuwait University Al-Rashed Allergy Center [Kuwait City] Pantai Hospital [Kuala Lumpur] Hospital Quirónsalud Bizkaia [Bilbao] Ghent University Hospital Karolinska Institutet [Stockholm] Karolinska University Hospital [Stockholm] Sun Yat-sen University [Guangzhou] Universiti Sains Malaysia Charité - UniversitätsMedizin = Berlin University Medicine Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Berlin Institute of Health Karolinska Institutet [Stockholm] Karolinska University Hospital [Stockholm] Odense University Hospital Skane University Hospital [Lund] Fondazione Policlinico Universitario Agostino Gemelli IRCCS National Heart and Lung Institute [London] Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] Woolcock Institute of Medical Research [Sydney] Guy's and St Thomas' Hospital [London] King‘s College London Università degli studi di Torino = University of Turin National Heart and Lung Institute [London] University of Cartagena Vall d'Hebron University Hospital [Barcelona] Centro Hospitalar de Lisboa Central E.P.E Centro de Estudos de Doenças Crónicas University of South Florida [Tampa] Azienda Usl Toscana centro [Firenze] Universidad Simon Bolivar David Tvildiani Medical University McMaster University [Hamilton, Ontario] Children's Clinical University Hospital [Riga, Latvia] Universidade Federal da Bahia = Federal University of Bahia Università degli Studi di Cagliari = University of Cagliari = Université de Cagliari Centre Hospitalier Régional Universitaire [Montpellier] Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] Institut Desbrest d'Epidémiologie et de Santé Publique Hôpital Foch [Suresnes] National Heart and Lung Institute [London] Sagamihara National Hospital [Kanagawa, Japan] Université Ain Shams Vilnius University [Vilnius] CHU Clermont-Ferrand IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital Academic Medical Center - Academisch Medisch Centrum [Amsterdam] European Forum for Research and Education in Allergy and Airway Diseases Universidade do Porto = University of Porto Silesian Medical University, Katowice, Poland Cerrahpasa Faculty of Medicine Erasmus University Medical Center [Rotterdam] Universidad de Chile = University of Chile [Santiago] Odense University Hospital Humanitas University [Milan] Humanitas Clinical and Research Center [Rozzano, Milan, Italy] Medical University of Vienna = Medizinische Universität Wien Université Ain Shams Hôtel-Dieu de France Tartu University Hospital Ukrainina Medical Stomatological Academy [Poltava, Ukraine] Hacettepe University = Hacettepe Üniversitesi Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro Siriraj Hospital, Mahidol University Nova Southeastern University Nofer Institute of Occupational Medicine National University of Singapore Yong Loo Lin School of Medicine [Singapore] McMaster University [Hamilton, Ontario] The Chinese University of Hong Kong Manisa Celal Bayar University Universidad Nacional de Villa María Universidad Católica de Córdoba = Catholic University of Córdoba Beijing Tongren Hospital Charité - UniversitätsMedizin = Berlin University Medicine Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Berlin Institute of Health
• Publié dans Clinical and Translational Allergy le 23/10/2020

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Fichiers liés : Clinical Translational All - 2021 - Bousquet - ARIA%u2010EAACI care pathways for allergen immunotherapy in respiratory allergy.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Hanspeter NaegeliJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneYann DevosSilvia FedericiAntonio Fernandez DumontAndrea GennaroJose Ángel Gómez RuizFranco Maria NeriNikoletta PapadopoulouKonstantinos ParaskevopoulosAnna Lanzoni
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Oilseed rape 73496 was developed to confer tolerance to the herbicidal active substance glyphosate through the expression of the glyphosate acetyltransferase protein GAT4621. The molecular characterisation data and bioinformatic analyses identify no issues requiring food/feed safety assessment. None of the identified differences between oilseed rape 73496 and its conventional counterpart in the agronomic/phenotypic endpoints tested needs further assessment. Differences identified in seed composition of oilseed rape 73496 as compared to its conventional counterpart raise no safety and nutritional concerns in the context of the scope of this application. No safety concerns are identified regarding toxicity and allergenicity of the GAT4621 protein as expressed in oilseed rape 73496. No evidence is found that the genetic modification would change the overall allergenicity of oilseed rape 73496. Based on the outcome of the comparative and nutritional assessments, the consumption of oilseed rape 73496 does not represent any nutritional concern, in the context of the scope of this application. The implementation of a post-market monitoring plan is recommended to confirm the predicted consumption data and to verify that the conditions of use are those considered during the pre-market risk assessment. In the case of accidental release of viable oilseed rape 73496 seeds into the environment, oilseed rape 73496 would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of oilseed rape 73496. The GMO Panel concludes that oilseed rape 73496, as described in this application, is as safe as its conventional counterpart and the non-genetically modified oilseed rape reference varieties tested with respect to potential effects on human and animal health and the environment.

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Fichiers liés : EFSA Journal - 2021 - - Assessment of genetically modified oilseed rape 73496 for food and feed uses under Regulation EC.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Nathalie JustHans AdriaensenArsène EllaPierre-Marie ChevillardMartine BataillerJean-Philippe DuboisMatthieu KellerMartine Migaud
• Organismes : Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly]
• Publié dans Brain Research le 29/10/2020

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Résumé : The ovine model could be an effective translational model but remains underexplored. Here, Blood Oxygen Level dependent functional MRI during visual stimulation and resting-state perfusion MRI were explored. We aimed at investigating the impact of isoflurane anesthesia during visual stimulation and evaluate resting cerebral blood flow and cerebral blood volume parameters in the lamb and adult sheep brain. BOLD fMRI and perfusion MRI after a bolus of DOTAREM were conducted in 4 lambs and 6 adult ewes at 3 T. A visual stimulation paradigm was delivered during fMRI at increasing isoflurane doses (1-3%). Robust but weak BOLD responses (0.21 +/- 0.08%) were found in the lateral geniculate nucleus (LGN) up to 3% isoflurane anaesthesia. No significant differences were found beween BOLD responses in the range 1 to 3% ISO (p > 0.05). However, LGN cluster size decreased and functional localization became less reliable at high ISO doses (2.5-3% ISO). BOLD responses were weaker in adult sheep than in lambs (4.6 +/- 1.5 versus 13.6 +/- 8.5; p = 0.08). Relative cerebral blood volumes (rCBV) and relative cerebral blood flows (rCBF) were significantly higher (p < 0.0001) in lambs than in adult sheep for both gray and white matter. The impact of volatile anesthesia was explored for the first time on BOLD responses demonstrating increased reliability of functional localization of brain activity at low doses. Perfusion MRI was conducted for the first time in both lambs and adult ewes. Assessment of baseline cerebrovascular values are of interest for future studies of brain diseases allowing an improved interpretation of BOLD responses.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Anne BlanchardKintur SanghviManish SaxenaPhilippe GosseJohn ReillyTerry LevyLars RumpAlexandre PersuJan BasileMichael BlochJoost DaemenMelvin D LoboFelix MahfoudRoland E SchmiederAndrew SharpBarthelemy von HallerMarc SapovalPete FongAtul PathakPierre LantelmeDavid HsiSripal BangaloreAdam WitkowskiJoachim WeilBenjamin KablyNeil BarmanHelen Reeve-StofferLeslie ColemanCandace McclureAjay J KirtaneJosh CostelloCourtney KrathanLuot LewisAndrew McelvarrStephen JenkinsMichael CashShannon WilliamsMaria JarvisCheryl LafferJames GainerMark RobbinsSherron CrookSarita MaddelScott MartinEdward PortnayMaryanne DuceySuzanne RoseElizabeth DelmastroStephen WilliamsStanley CabosCarolina Rodriguez AlvarezThomas TodoranEric PowersEmily HodskinsVijay PaladuguAnna TecklenburgChandan DevireddyJanice LeaBryan WellsAmanda FiebachClaudia MerlinFlorian RaderSuhail DohadHyun-Min KimMohammad RashidJosephine AbrahamTheophilus OwanAnu AbrahamIran LavasaniHailey NeilsonDavid CalhounThomas McelderryWilliam MaddoxSuzanne OparilSheila KinderJai RadhakrishnanCandido BatresSuzanne EdwardsJoseph GarasicDoug DrachmanRandy ZusmanKenneth RosenfieldDanny DoMatheen KhuddusSuzanne ZentkoJames O'MearaIlie BarbAbby FosterAlice BoyetteYale WangDesmond JayNedaa SkeikRobert SchwartzRose PetersonJo Anne GoldmanJessie GoldmanGary LedleyNancy KatofSrinivasa PotluriScott BiedermannJacquelyn WardMegan WhiteNaomi Dl FisherLaura MauriPiotr SobieszczkyAlex SmithLaura AseltineRick StoufferAlan HinderliterEric PauleyTyrone WadeDavid ZidarMehdi ShishehborBarry EffronMarco CostaTerence SemenecChanwit RoongsritongPriscilla NelsonBridget NeumannDebbie CohenJay GiriRobin NeubauerThu VoAtul ChughPei-Hsiu HuangPowell JoseJohn FlackRobert FishmanMichael JonesTodd AdamsChristopher BajzerAnthony MathurAjay JainArmida BalawonOlivier ZongoClare BentDavid BeckettNicki LakemanSarah KennardRichard d'SouzaSarah StattonLindsay WilkesChristine AnningJeremy SayerSudha Ganesh IyerNicholas RobinsonAnnaliza SevillanoMadelaine OcampoRobert GerberMohamad FarisAndrew John MarshallJanet SinclairHayley PepperJustin DaviesNeil ChapmanPaula BurakPaula CarvelliSachin JadhavJane QuinnLars Christian RumpJohannes StegbauerLars SchimmöllerSebastian PotthoffClaudia SchmidSylvia RoederLukas HaferTolga AgdirliogluTanja KöllnerMichael BöhmSebastian EwenSaarraaken KulenthiranAngelika WachterChristina KochPhilipp LurzKarl FenglerKarl-Philipp RommelKai TrautmannMartin PetzoldChristian OttAxel SchmidMichael UderUlrike HeinritzKerstin Fröhlich-EndresSabine Genth-ZotzDenise KämpfnerArmin GraweJohannes HöhneBärbel KaesbergerConstantin von Zur MühlenDennis WolfMarkus WelzelGudrun HeinrichsBarbara TrabitzschAntoine CremerHervé TrillaudPanteleimon PapadopoulosFlorent MaireJulie GaudissardErika CornuDavid FouassierMarine LivrozetAurélien LorthioirValérie PaquetBenjamin HontonMarianne CottinFrédéric PetitConstance BergePierre-Yves CourandFatou LangevinPascal DelsartBenjamin LongereGuillaume LedieuFrançois PontanaCoralie SommevilleFabien BertrandLida FeyzVictor ZeijenArno RuiterElisabeth HuyskenPeter BlankestijnMichiel VoskuilZwaantina RittersmaHelma DolmansA KroonW van ZwamJeannique VrankenClaudia de HaanJean RenkinFrédéric MaesChristophe BeauloyeJean-Philippe LengeléDominique HuyberechtsAnne BouvieAndrzej JanuszewiczJacek KdzielaAleksander PrejbisjDagmara HeringDariusz CiecwierzMilosz JaguszewskiRadoslaw Owczuk
• Organismes : Imagerie Ultrasonore Imagerie Ultrasonore
• Publié dans The Lancet le 02/11/2020

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Fichiers liés : S0140673621007881.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Xavier MoissetAudrey-Anne FouchardBruno PereiraFrederic TaitheGuillaume MatheyGilles EdanJonathan CironBruno BrochetJérôme de SèzeCaroline PapeixPatrick VermerschPierre M LabaugeGilles DeferChristine Lebrun-FrénayThibault MoreauDavid-Axel LaplaudEric BergerJean PelletierBruno StankoffOlivier GoutEric ThouvenotOlivier HeinzlefAbdullatif Al-KhedrBertrand BourreOlivier CasezPhilippe CabreAlexis MontcuquetAlain CreangeJean-Philippe CamdessanchéSerge BakchineAude MauroussetKarolina HankiewiczCorinne PottierNicolas MaubeugeDalia Dimitri BoulosChantal NifleSandra VukusicPierre Clavelou
• Organismes : CHU Clermont-Ferrand CHU Clermont-Ferrand CHU Clermont-Ferrand CHU Clermont-Ferrand Adaptation, mesure et évaluation en santé. Approches interdisciplinaires Service de neurologie [CHRU Nancy] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Toulouse Université de Bordeaux Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire [Strasbourg] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Lapeyronie [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Pasteur [Nice] Centre d'épidémiologie des populations Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie Centre Hospitalier Régional Universitaire de Besançon Hôpital de la Timone [CHU - APHM] CHU Saint-Antoine [AP-HP] Fondation Ophtalmologique Adolphe de Rotschild Institut de Génomique Fonctionnelle CHI Poissy-Saint-Germain CHU Amiens-Picardie CHU Rouen Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] CHU Limoges CHU Henri Mondor [Créteil] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital universitaire Robert Debré [Reims] CHU Trousseau [Tours] Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier René Dubos [Pontoise] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier Versailles, 78000 Le Chesnay, France Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Université Claude Bernard Lyon 1 CHU Clermont-Ferrand
• Publié dans European Journal of Neurology le 22/10/2020

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Résumé : Background and purpose: Disease-modifying therapies (DMTs) have an impact on relapses and disease progression. Nonetheless, many patients with multiple sclerosis (MS) remain untreated. The objectives of the present study were to determine the proportion of untreated patients with MS followed in expert centers in France and to determine the predictive factors of nontreatment. Methods: We conducted a retrospective cohort study. Data were extracted from the 38 centers participating in the European Database for Multiple Sclerosis (EDMUS) on December 15, 2018, and patients with MS seen at least once during the study period (from June 15, 2016 to June 14, 2017) were included. Results: Of the 21,189 patients with MS (age 47.1 +/- 13.1 years; Expanded Disability Status Scale (EDSS) score 3.4 +/- 2.4), 6,631 (31.3%; 95% confidence interval [CI] 30.7-31.9) were not receiving any DMT. Although patients with a relapsing-remitting course (n = 11,693) were the most likely to receive DMT, 14.8% (95% CI 14.2-15.4) were still untreated (6.8% never treated). After multivariate analysis among patients with relapsing-remitting MS, the main factors explaining never having been treated were: not having >= 9 lesions on brain magnetic resonance imaging (odds ratio [OR] 0.52 [95% CI 0.44-0.61]) and lower EDSS score (OR 0.78 [95% CI 0.74-0.82]). Most patients with progressive MS (50.4% for secondary and 64.2% for primary progressive MS) did not receive any DMT during the study period, while 11.6% of patients with secondary and 34.0% of patients with primary progressive MS had never received any DMT. Conclusion: A significant proportion of patients with MS did not receive any DMT, even though such treatments are reimbursed by the healthcare system for French patients. This result highlights the unmet need for current DMTs for a large subgroup of patients with MS.

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Fichiers liés : Moisset et al - 2021 - Untreated patients with multiple sclerosis.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Joel BergéLaura BaudisPhilippe BraxSheng-Wey ChiowBruno ChristopheOlivier DoréPierre FayetAurélien HeesPhilippe JetzerClaus LämmerzahlMeike ListGilles MetrisMartin Pernot-BorràsJustin ReadSerge ReynaudChristian L. ReichardtBenny RieversManuel Jorge RodriguesTimothy SumnerJean-Philippe UzanNan Yu
• Organismes : DPHY, ONERA, Université Paris Saclay [Châtillon] Physik-Institut [Zürich] Institut de Physique Théorique - UMR CNRS 3681 Jet Propulsion Laboratory DPHY, ONERA, Université Paris Saclay [Châtillon] Jet Propulsion Laboratory Champs, Gravitation et Cordes Systèmes de Référence Temps Espace Physik-Institut [Zürich] Center of Applied Space Technology and Microgravity German Aerospace Center Géoazur DPHY, ONERA, Université Paris Saclay [Châtillon] Department of Physics, University of Surrey Laboratoire Kastler Brossel Jet Propulsion Laboratory Center of Applied Space Technology and Microgravity DPHY, ONERA, Université Paris Saclay [Châtillon] Blackett Laboratory Institut d'Astrophysique de Paris Jet Propulsion Laboratory
• Publié dans Experimental Astronomy le 29/10/2020

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Résumé : We speculate on the development and availability of new innovative propulsion techniques in the 2040s, that will allow us to fly a spacecraft outside the Solar System (at 150 AU and more) in a reasonable amount of time, in order to directly probe our (gravitational) Solar System neighborhood and answer pressing questions regarding the dark sector (dark energy and dark matter). We identify two closely related main science goals, as well as secondary objectives that could be fulfilled by a mission dedicated to probing the local dark sector: (i) begin the exploration of gravitation’s low-acceleration regime with a spacecraft and (ii) improve our knowledge of the local dark matter and baryon densities. Those questions can be answered by directly measuring the gravitational potential with an atomic clock on-board a spacecraft on an outbound Solar System orbit, and by comparing the spacecraft’s trajectory with that predicted by General Relativity through the combination of ranging data and the in-situ measurement (and correction) of non-gravitational accelerations with an on-board accelerometer. Despite a wealth of new experiments getting online in the near future, that will bring new knowledge about the dark sector, it is very unlikely that those science questions will be closed in the next two decades. More importantly, it is likely that it will be even more urgent than currently to answer them. Tracking a spacecraft carrying a clock and an accelerometer as it leaves the Solar System may well be the easiest and fastest way to directly probe our dark environment.

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Fichiers liés : Bergé2021_Article_TheLocalDarkSector.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : David TougeronBarbara Seitz Seitz-PolskiMaxime HentzienFirouzé Bani-SadrJean BourhisMichel DucreuxSébastien GaujouxPhilippe GorpheBoris GuiuAnne Claire Hardy-BessardKhê Hoang XuanFlorence HuguetThierry LecomteAstrid LièvreChristophe LouvetLéon MaggioriPascale MarianiPierre MichelAmélie ServettazJuliette ThariatVirginie WesteelThomas AparicioJean-Yves BlayOlivier Bouché
• Organismes : Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU Nice [Cimiez] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] UNICANCER Institut Gustave Roussy Département de médecine oncologique [Gustave Roussy] CHU Pitié-Salpêtrière [AP-HP] Institut Gustave Roussy Département de cancérologie cervico-faciale [Gustave Roussy] Centre Hospitalier Régional Universitaire [Montpellier] Institut Desbrest d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Universitaire de Cancérologie [Sorbonne Université] CHU Trousseau [Tours] Chemistry, Oncogenesis, Stress and Signaling Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Cooperator Multidisciplinary Oncology Group Hopital Saint-Louis [AP-HP] Institut Curie [Paris] Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Hôpital universitaire Robert Debré [Reims] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Hopital Saint-Louis [AP-HP] Centre Léon Bérard [Lyon] Hôpital universitaire Robert Debré [Reims]
• Publié dans Bulletin du Cancer le 01/11/2020

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Résumé : The COVID-19 pandemic has a major impact at all stages of cancer treatment. Risk of death from COVID-19 in patients treated for a cancer is high. COVID-19 vaccines represent a major issue to decrease the rate of severe forms of the COVID-19 cases and to maintain a normal cancer care. It is difficult to define the target population for vaccination due to the limited data available and the lack of vaccine doses available. It appears theoretically important to vaccinate patients with active cancer treatment or treated since less than three years, as well as their family circle. In France, patients actually defined at "high risk" for priority access to vaccination are those with a cancer treated by chemotherapy. A panel of experts recently defined another "very high-priority" population, which includes patients with curative or palliative first or second-line chemotherapy, as well as patients requiring surgery or radiotherapy involving a large lung volume, lymph nodes and/or of hematopoietic tissue. Ideally, it is best to vaccinate before cancer treatment. Despite the lack of published data, COVID-19 vaccines can also be performed during chemotherapy by avoiding periods of bone marrow aplasia and if possible, to do it in cancer care centers. It is necessary to implement cohorts with immunological and clinical monitoring of vaccinated cancer patients. To conclude, considering the current state of knowledge, the benefit-risk ratio strongly favours COVID-19 vaccination of all cancer patients.

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Fichiers liés : Tougeron et al-2021-Vaccination contre la COVID-19 des patients atteints de cancer solide.pdf

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