Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/05/2021
• Auteurs : Antonin TomassoCéline Bressy-LeandriDidier BinderVincent DelvignePaul FernandesChristophe TufféryPierre AllardThierry AubryAlain BeechingVincent BlouetChristophe BorgnonFrançoise BostynJacques Léopold BrochierJean-Philippe CollinVéronique BrunetGuilhem ConstansSylvie Coutard
• Organismes : Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Centre National de la Recherche Scientifique Service régional de l'archéologie, Ajaccio Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Centre National de la Recherche Scientifique Centre National de la Recherche Scientifique Technologie et Ethnologie des Mondes Préhistoriques SARL Paleotime, 38250 Villard-de-Lans Technologie et Ethnologie des Mondes Préhistoriques Technologie et Ethnologie des Mondes Préhistoriques Institut national de recherches archéologiques préventives Centre National de la Recherche Scientifique Technologie et Ethnologie des Mondes Préhistoriques ARCHEORIENT - Environnements et sociétés de l'Orient ancien Service régional de l'archéologie du Grand Est, site de Metz Institut national de recherches archéologiques préventives Trajectoires - UMR 8215 Université Paris 1 Panthéon-Sorbonne - UFR Histoire de l'art et archéologie Centre National de la Recherche Scientifique Laboratoire méditerranéen de préhistoire Europe-Afrique Centre de recherches en archéologie et patrimoine Trajectoires - UMR 8215 Institut national de recherches archéologiques préventives Trajectoires - UMR 8215 Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels

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Résumé : L’élaboration des lithothèques constitue l’un des piliers de la recherche sur la caractérisation et la provenance des roches siliceuses taillées durant la Préhistoire. Depuis plus de 40 ans, dans de multiples régions, des prospections sont menées pour documenter et échantillonner les gîtes de matériaux siliceux qui sont autant de sources potentielles d'approvisionnement des groupes préhistoriques. Ces référentiels, hétérogènes, ont été construits de manières diverses et la recherche demeure à ce jour fortement cloisonnée. Or, la connaissance des potentialités siliceuses à grande échelle est essentielle pour mettre en évidence des circulations à longue distance, de nature à modifier notre perception des territoires durant la Préhistoire. À partir d’une enquête nationale sur les lithothèques, a été initiée une démarche de mise en réseau des acteurs portée par le Groupe de recherche Silex. Elle vise à pérenniser les données (base de données) ainsi qu’à partager et harmoniser les pratiques pour redéfinir le périmètre scientifique des lithothèques. Périmètre qui évolue en fonction des méthodologies appliquées et des problématiques actuelles de la recherche préhistorique.

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• Type de publi. : Article dans une revue
• Date de publi. : 03/05/2021
• Auteurs : Anne MontfortFlorie BertrandJulia RochotteJulia GilhodesThomas FilleronJean MilhèsCarine DufauCaroline ImbertJoelle RiondMarie TosoliniChristopher ClarkeFlorent DufourAndrei ConstantinescuNilton de França JuniorVirginie GarciaMichel RecordPierre CordelierPierre BroussetPhilippe RochaixSandrine Silvente-PoirotNicole ThervilleNathalie Andrieu-AbadieThierry LevadeYusuf HannunHervé BenoistNicolas MeyerOlivier MicheauCéline ColaciosBruno Ségui
• Organismes : Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Stony Brook University [SUNY] Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Fédératif de Biologie (IFB) Stony Brook University [SUNY] Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Lipides - Nutrition - Cancer [Dijon - U1231] Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse
• Publié dans Cancer Immunology Research le 20/04/2021

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Résumé : Dysregulation of lipid metabolism affects the behavior of cancer cells, but how this happens is not completely understood. Neutral sphingomyelinase 2 (nSMase2), encoded by SMPD3, catalyzes the breakdown of sphingomyelin to produce the anti-oncometabolite ceramide. We found that this enzyme was often downregulated in human metastatic melanoma, likely contributing to immune escape. Overexpression of nSMase2 in mouse melanoma reduced tumor growth in syngeneic wild-type but not CD8-deficient mice. In wild-type mice, nSMase2-overexpressing tumors showed accumulation of both ceramide and CD8+ tumor-infiltrating lymphocytes, and this was associated with increased level of transcripts encoding IFNγ and CXCL9. Overexpressing the catalytically inactive nSMase2 failed to alter tumor growth, indicating that the deleterious effect nSMase2 has on melanoma growth depends on its enzymatic activity. In vitro, small extracellular vesicles from melanoma cells overexpressing wild-type nSMase2 augmented the expression of IL12, CXCL9, and CCL19 by bone marrow-derived dendritic cells, suggesting that melanoma nSMase2 triggers T helper 1 (Th1) polarization in the earliest stages of the immune response. Most importantly, overexpression of wild-type nSMase2 increased anti-PD-1 efficacy in murine models of melanoma and breast cancer, and this was associated with an enhanced Th1 response. Therefore, increasing SMPD3 expression in melanoma may serve as an original therapeutic strategy to potentiate Th1 polarization and CD8+ T-cell-dependent immune responses and overcome resistance to anti-PD-1.

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Fichiers liés : 568.full.pdf

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• Type de publi. : Rapport
• Date de publi. : 03/05/2021
• Auteurs : Marion FouchardJean-Pierre HébrardPhilippe Ponel
• Organismes : Ligue pour la protection des oiseaux PACA Institut méditerranéen de biodiversité et d'écologie marine et continentale Institut méditerranéen de biodiversité et d'écologie marine et continentale

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Fichiers liés : Fouchard et al Rapport 2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Thomas BénetSélilah AmourMartine ValetteMitra Saadatian-ElahiLudwig Serge Aho-GléléPhilippe BerthelotMarie-Agnès DenisJacqueline GrandoCaroline LandelleKarine AstrucAdeline ParisSylvie PilletBruno LinaPhilippe VanhemsMarc BardouJean-Baptiste BourLuc FontanaMarie-Reine MallaretJulien LupoPatrice MorandPierre PothierBruno PozzettoOlivier RobertHenri Jacques Smolik
• Organismes : Santé publique France - French National Public Health Agency [Saint-Maurice, France] Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hospices Civils de Lyon Service d'épidémiologie et d'hygiène hospitalières (CHU de Dijon) Université Jean Monnet - Saint-Étienne Hospices Civils de Lyon Centre National de Reference des Staphylocoques Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre Hospitalier Universitaire [CHU Grenoble] Modélisation et Évaluation des données complexes en Santé Publique Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre d'Investigation Clinique [Grenoble] Groupe Immunité des Muqueuses et Agents Pathogènes Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Virology and human respiratory Pathologies - Virology and human respiratory Pathologies [CIRI] Hôpital Edouard Herriot [CHU - HCL] Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie Laboratoire de sérologie-virologie (CHU de Dijon) Department of Occupational Medicine, University Hospital of Saint-Etienne, F-42055 Saint-Etienne, France. Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre Hospitalier Universitaire [CHU Grenoble] Institut de biologie structurale Institut de biologie structurale Centre National de Référence des virus entériques [CHU de Dijon] French Rotavirus Network
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : Abstract Background Influenza is an important cause of viral hospital-acquired infection involving patients, healthcare workers (HCW), and visitors. The frequency of asymptomatic influenza among HCW with possible subsequent transmission is poorly described. The objective is to determine the cumulative incidence of asymptomatic, paucisymptomatic, and symptomatic influenza among HCW. Method A multicenter prospective cohort study was done in 5 French university hospitals, including 289 HCW during the 2016–2017 influenza season. HCW had 3 physical examinations (time [T] 0, before epidemic onset; T.1, before epidemic peak; T.2, T.3, after epidemic peak). A blood sample was taken each time for influenza serology and a nasal swab was collected at T1 and T2 for influenza detection by polymerase chain reaction (PCR). Positive influenza was defined as either a positive influenza PCR, and/or virus-specific seroconversion against influenza A, the only circulating virus, with no vaccination record during follow-up. Symptoms were self-reported daily between T1 and T2. Cumulative incidence of influenza was stratified by clinical presentation per 100 HCW. Results Of the 289 HCW included, 278 (96%) completed the entire follow-up. Overall, 62 HCW had evidence of influenza of whom 46.8% were asymptomatic, 41.9% were paucisymptomatic, and 11.3% were symptomatic. Cumulative influenza incidence was 22.3% (95% confidence interval [CI]: 17.4%–27.2%). Cumulative incidence of asymptomatic influenza was 5.8% (95% CI: 3.3%–9.2%), 13.7% (95% CI: 9.9%–18.2%) for paucisymptomatic influenza, and 2.9% (95% CI: 1.3%–5.5%) for symptomatic influenza. Conclusions Asymptomatic and paucisymptomatic influenza were frequent among HCW, representing 47% and 42% of the influenza burden, respectively. These findings highlight the importance of systematic implementation of infection control measures among HCW regardless of respiratory symptoms from preventing nosocomial transmission of influenza. Clinical Trials Registration NCT02868658.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Mark McclanahanMichael DempseyHelen ColhounIsabelle ZobouyanPatrick PicaultAurelie PerthuisChristine MorrelloDominique Fournie-LloretZhu ChengyueRaluca CotrutaMarion VincendetMarc SottyMaxime MourguesLamia MetwallyBenjamin HalleHelene Dubois-GachePauline BarraudPascale BeltranAntony AdamoChristelle RondelAnne OurliacMickael NormandVirginie LoizeauValerie GouetAlexis EtienneChristelle LorenzatoJérôme RepincayChristelle BerthouAnthony CoulangeRaphael BejuitMichel ScemamaKatarina KralovaMaud LamoureuxNafissa BengraitFadela BenbernouValerie PellanSebastien SopenaJennifer ShellerLucile SmithBetim OkanBicky MthombeniAsmaa MrabtiUlises MoralesMyriam MonierJulien LabeirieCarine JavierreGayatri JaiwalMegan HeathJan HealySeverine GuillouCaroline GobillotCecile GacheSzilvia DomokosDawn DevaulJoseph CianciaruloMaddy BrocklehurstImane BriguiCecile BouancheauMhamed BekkoucheEmmy BadreddineDorthe AndersenVeronique AgnettiMelanie VerrierJudith MurphySylvie FontecaveDouglas FaustinoNathalie BougonMarie-France BrégeaultShahidul IslamLena GrunbergMichelle ShawLiddy GriffithJulie ButtersAnne LuytenCaroline AlsweilerTabassome SimonElodie DrouetMadeleine BezaultCarla RovitoAndrea PascualMelissa WestbrookTyrus RorickKirby QuinteroAnita HepditchLisa BerdanJanine ValirisCaroline RatkyAlexander MatthewsJulianna WozniakJanaina OliveiraAnelise KawakamiFlavia EgydioEric BallDavid LaxsonJohn HunterJohn KostisKishor VoraRamprasad DandillayaGeraldine GardnerBill HarrisDouglas JacobyJay AndersonRichard GilmoreRobert FosterJames WelkerTerry WellsJoanne CoblerJustine KrawczykLaura AkrightDawood GamilHoward RubensteinGregory GieslerMichael LovePurushotham KothaGary ConradNizar AssiTammam Al JoundiAref RahmanJohn Paul GibsonAlexander MacdonellDouglas DenhamImran DotaniStuart ChristensonJohn SchmedtjeCharles EatonGopal ChalavaryaJohn GilbertBranislav SchifferdeckerJohn HenrySherrill MurphyMark ChangWilliam PennyJessica BirchemHimanshu AgarwalSandeep KhuranaDonald WesterhausenWilliam KeenHenry LuiSuhail DohadRonald KarlsbergCarlos BayronMark ZaineaDiwakar JainP. Sandy SundramMichael SchwartzSamir TurkMartin McgoughJoel LandzbergSteven EisenbergDwight StapletonDaniel SpornMichael RadinEric YangRobert BarruccoRobert FishbergMichael BerlowitzHinan AhmedRiyaz BashirMukesh SharmaRakesh VohraPaul NagerTheodore PopeAhed NahhasF. Martin LesterKapildeo LotunNampalli VijayJason HallMajed ChaneAnthony VoSuneet MittalJanet StrainDouglas SpriggsSeals AlbertEdward PereiraSteven SchwartzMark NeustelLawrence GimpleDouglas GuySteve DiamantisWilliam FrenchStewart PollockMichael FarrarNorman ErenrichMichael RaySamir PancholyDonald EagertonEugene SorokaStuart FischerDavid HoffmanStephen WelkaJoshua PurowSteven LupovitchGreg KumkumianAjit KhairaAmit KheraParag JoshiPeter RossiMartin BerkRohr KathrynRobert WeissEdmund ClaxtonH. John MaraisKwan LeeAjay LabrooAyim Akyea-DjamsonRonald BlonderJames StraderRavi BhagwatNeal PerlmutterMark XenakisDaniel FisherSridhar BanuruNaseem JaffraniDinesh SingalPhilip O’donnellKeattiyoat WattanakitClara MasseyGeert JongChristopher MalozziAndreas WaliMohamadali AmlaniAndrey EspinozaGlen TonnessenMalcolm FosterKevin SilverJeffrey KuvinCarey KimmelstielPhillip RozemanArthur LoussararianFred ChaleffDennis FriedmanThomas KnutsonMladen VidovichHyeun (tom) ParkLiwa YounisJaime GerberCharles CareyMarilyn KingGeorge VetrovecAntonio AbbateAjit RaisinghaniCharles LambertJames FairlambGregory RoseJoseph RossiZachary HodesEbrahimi RaminFreny ModyAlan ChuThomas GalskiDaniels ChristopherWade MayAlvaro AlonsoAnand IrimpenHoward WeintraubMahfouz El ShahawyNorman LeporParilak LeonardEichenlaub TimothyRosemary NowinsJason LindseyKeith FriedmanWilliam HerzogRobert PedersonMark PiconeCarsten SchmalfussMasoud AzizadWilliam SheldonThomas BlokStephen VoyceVipul PanchalJoseph McgarveyZubair JafarGeorge PonceFiras ZahrPhillip HorwitzNizar DaboulRolf AndersenShawn SpeirsJack WhitakerSharan MahalGeoffrey KlineNaim FarhatTimothy SchuchardDavid HendersonChristian GringBabak VakiliNandkishore RanadiveSumeet SubherwalOthman IslamMatthew WhiteJalal AbbasStephen ThewWenwu ZhangBrent MclaurinPeter KuhlmanEdward TeufelJohn LarryArnold GhitisGeorge KinzfoglAnna BortnickChad LinkRose DoBrack HattlerAnil KumarMark IzzoRahul AggarwalVipul ShahMazen Abu-FadelTheodore TakataWinfried WaiderHoward LeviteSanjay ShettyNicholas KondoFriederike KeatingKerensky RichardChristopher DanielsJoseph GelorminiBrett BermanCarl PepineDenise JanosikAnil ShahNarendra SinghSarah FentonJames RiderWayne LeimbachAmarnath VedereMaitreya ThakkarJohn PasquiniShahram YazdaniWilliam DavisJohn KobayashiAndrew SumnerJoseph MoranMatthew JanikJames BengstonTauqir GorayaGeorge DoddsHarish ChandnaMichael KorenSai DevarapalliVinay MalhotraKim KlanckeIon JovinAngel MulkaySunder RaoAmir MalikTariq HaddadKenneth SabatinoDaniel DotyLuther CarterSteven CohenBarry HarrisKatie MoriartyWilliam NelsonFadi El-AhdabMichael d'UrsoEric CarlsonFaiq AkhterMouhamad AbdallahImran ArifDavid SuhThomas AmidonEve GillespieThomas HaldisThomas KnickelbineLindsey WhiteMian HasanPerry KrichmarCara EastPriya KumarIra LieberPatrick CambierGeorges DagherMohammad ShoukfehMisal KhanJonathan WaltmanLes ForgoshEdward KosinskiWilliam RogersMichael RosenbergShi-Chi ChengScott WrightEnrique FloresCarlos InceAnn Elizabeth MohartSanjeev PuriAbul KhanAlan WisemanBruce PalmerCharles DahlCharles Treasure IiDavid BrabhamDuccio BaldariGil VardiNicholas Ossei-GerningSean GallagherJulian HalcoxDavid FitzmauricePeter WilkinsonRob ButlerDavid SprigingsDavid SharmanTimothy ReynoldsAyyaz SultanGohar RahmanTelal MudawiSimon ThackrayRichard OliverMuhammad CheemaMohammad AyazAdrian BrodisonAnthony MathurHandrean SoranAudrius SimaitisRobert GerberHoner KadrCraig BarrTerry LevyJohn KurianSimon SmithRangasamy MuthusamySam McclureHuw GriffithsRobert StoreyDavid SarkarDenise BraganzaEduardas SubkovasSyed M.R. IqbalYuk-Ki WongPiers CliffordRajesh AggarwalAndrew MoriartyKaeng LeeAzfar ZamanJasper TrevelyanVolodymyr ZheleznyyAnatolii RudenkoBorys GoloborodkoGeorgiy DzyakOlexiy UshakovOlga BarnaAndriy BagriyMykola VatutinAndriy YagenskyMykola KopytsyaMykola RishkoOleh LeshchukViktor TashchukEkaterina AmosovaOles KutniyAndriy KlantsaYaroslav MalynovskyYuriy KarpenkoYulian KyiakMykola StanislavchukYuriy MostovoyVira TseluykoMykola KushnirIhor KovalskyiLeonid RudenkoValeriy BatushkinDmytro ReshotkoHalyna MyshanychIhor VakaluykAlexander ProkhorovOleksandr KarpenkoLale KoldasErtan UralCevat KirmaMustafa DemirtasMurat ErsanliBulent MutluHakan KultursayAhmet CamsariPaiboon ChotnoparatpatDilok PiyayotaiWirash KehasukcharoenNakarin SansanayudhKrisada SastravahaNattawut WongpraparutApichard SukonthasarnWoravut JintapakornWasant SoonfuangPinij KaewsuwannaChih-Yuan FangTsuei-Yuan HuangJen-Yuan KuoWei Hsiang LinMing-Jer HsiehI-Chang HsiehWei-Hsian YinJuey-Jen HwangMing-En LiuWen-Ter LaiKwo-Chang UengWei-Chuan TsaiOliver GämperliRonald BindeFrancois MachChristian MüllerTiziano MoccettiTorbjörn SundelinUlf AhremarkIngemar TorstenssonSteen Agergaard JensenStefano RomeoOle HansenPeter NicolGeorgios MourtzinisNils WittOla VedinGundars RasmanisStefan BerglundNaomali AmarasenaJagath HerathAjantha RajapakshaThilak SirisenaGnanamoorthy MayurathanVajira SenaratneSepalika MendisRuvan EkanayakaGotabhaya RanasingheSantharaj WijeyasingamJayanthimala JayawardenaKaputella FernandoNimali FernandoChandrike PonnamperumaStanley AmarasekeraNirmali TisseraRuvaiz HaniffaGodwin ConstantinePedro ValdivielsoNorberto Alonso OrcajoAntonio Coca PayerasJuan EscudierJavier Balaguer RecenaPablo Loma-Osorio RinconCésar Morís de La TassaIgnacio Plaza PerezMercedes Camprubí PotauCarlos Gonzalez-JuanateyAmparo BenedictoGabriel Gusi TragantJavier Botas RodriguezJuan Cosín SalesJosé Alberto García LledóJose Francisco Díaz FernándezJosé Antonio Vázquez de PradaJosé de Berrazueta FernándezJose Maria Serrano AntolinJoaquin Alonso MartinJordi Bruguera CortadaManuel de Mora MartinJose Luis ZamoranoLaia Matas PericasFernando Civeira MurilloJavier Fernandez PortalesJose Gonzalez-JuanateyJosé Tuñón FernándezAndres IñiguezDavid Garcia-DoradoFernando Worner DizPablo ToledoBlas Gil-ExtremeraRafael Jesus Hidalgo UrbanoJose Cruz FernándezFrancisco MarínFrancisco Fuentes JimenezVicente Bodí PerisAngel Cequier FillatManuel VidaRajendran MoodleyHelmuth ReuterJoseph MynhardtMahomed SarvanIftikhar EbrahimGarda RiazSoraya CassimjeePatrick CommerfordJan SaaimanThayabran PillayPeter SebastianLouis van ZylDina van AswegenHanlie LotteringMatthys de V. BassonIlse KappHendrik Du Toit TheronEllen Makoali MakotokoJunaid BayatClive CorbettNaresh RanjithHenry CysterMatija CevcNataša Černič ŠuligojJanez PoklukarIvan ŽuranPeter OlexaAndrej DukatRudolf SmikJaroslava StrbovaGabriel KamenskyJuraj SeleckyViliam BuganJozef GonsorcikFrantišek FazekasAndrej DzupinaIvan MajercákJuraj MazurJuraj PalkaMarian HranaiPeter FulopDaniel PellaJan NociarKarol MickoJustin Tang I-ShingHean Yee OngKian-Keong PohTamara JakimovSinisa DimkovicSlobodan DodicAna KaradzicPetar SeferovicDragan DincicJovan BalinovacBranislava TodicSlavica RadovanovicAleksandra ArandjelovicAleksandar StankovicBiljana Putnikovic TosicStevan IlicSvetlana ApostolovicStevo StojicMilika AsaninNebojsa TasicGoran DavidovicNikola IvanovicDragan SimicSergey KanorskyMasterov IlyaIgor IvanovVadim TyrenkoLiudmila EgorovaAnton PovzunYuriy KarpovElena KosmachovaZaur ShogenovElena BaranovaLiudmila GaponKonstantin NikolaevOlga MolchanovaTatiana SotnikovaOlga ReshetkoNiiaz KhasanovIvan GordeevSergey YakushinSergey ShustovEvgeny BaranovTatyana TretyakovaMikhail VoevodaIgor LibovGalina ChumakovaEvgenia AkatovaVladimir ShchekotovNatalya OsokinaInna ViktorovaPetr ChizhovLarisa KhaishevaSergey ShalaevTatiana KhlevchukIgor BokarevNikita LomakinRaisa StryukVictor GurevichAlexander VishnevskyKonstantin ZrazhevskyAlexander GordienkoNadezhda LyaminaValentin MarkovOlga BarbarashZhanna KobalavaOlga OrlikovaYury ShvartsDoina DimulescuRodica Stanescu-CioranuIoan ComanMihaela MalisTom AlexandruAdrian MateiIrinel ParepaDoina RosuConstantin MilitaruCristina BengusMircea C.A. ConstantinescuCristian G.C. PodoleanuSilviu DumitrescuGabriel CristianDan TesloianuOctavian IstratoaieBogdan MinescuFrancisca CaetanoAna BotelhoCarlos MendonçaFilipe SeixoDinis MartinsHelder PereiraJose Mesquita BastosPedro MonteiroHanna SzwedGrzegorz RaczakEdward FranekJerzy GornyAndrzej LubinskiJacek GniotEwa Mirek-BryniarskaTomasz CzerskiMarek KorolMichal SzpajerLeszek BystrykTomasz BlicharskiArkadiusz StasiewskiRyszard SciborskiAnna DrzewieckaMarek PiepiorkaEdyta Kostarska-SrokoszJan Andrzej LipkoJacek KubicaBeata MiklaszewiczMarcin SkorskiAleksander ZurakowskiWanda SudnikWlodzimierz KrasowskiKrzysztof SaminskiElzbieta DulakPawel StanetaAleksander GochJanusz BednarskiBenita Busz-PapiezPawel WojewodaLidia PawlowiczGrzegorz SkoniecznyKrystyna JaworskaAdrian WlodarczakDennis Jose SulitEdgar TanDante MoralesGregorio RogelioAlisa BernanRaul Martin CochingGeneroso MatigaRody SyLouie TiradorRosa Allyn G. SyArthur FerrolinoWalter Mogrovejo RamosCarlos Zea NunezHenry Anchante HernandezVíctor Rodriguez ChavezYudy Roldan ConchaNassip Llerena NavarroJavier Heredia LandeoJorge Bravo MannucciLuis Camacho CosavalenteJose Hernandez ZunigaRolando Vargas GonzalesReynaldo Castillo LeonCarlos Chavez AyalaJesus Carrion ChambillaEnrique Sanabria PerezSandra Negron MiguelJulio Durand VelasquezJorge Calderon TiconaUlf HurtigErlend Gyllensten SingsaasPeter MunkJarle JortveitLars GullestadKjell AndersenJon Arne SparbyOttar NygårdTadeusz TomalaLaura DavidsonRussell AnscombeDenise AitkenSamuel WilsonNicholas FisherIan TernouthScott HardingRalph StewartHamish HartMichael SchubnellRaewyn FisherGerard WilkinsJohn ElliottSaman RasoulAntonius T.M. GosselinkFrank WillemsFerry M.R.J. HersbachRemco NijmeijerMarcel J.J.A. BokernBernard J.W.M. RensingAnho A.H. LiemPatrick N.A. BronzwaerBjorn GroenemeijerEelko RonnerRaymond LionaronsRefik KaplanCoenraad van Der ZwaanReginald G.E.J. GroutarsRobert BosJohannes P.R. HerrmanWalter R.M. HermansJan CornelGerard BartelsNadea Y.Y. Al-WindyEric ViergeverRoland P.T. TroquayBart R.G. BruerenGerardus J.E. VerdelJohan JukemaIoannis KaralisHenricus van KesterenPascalle MonraatsPeter ZwartRuud M.A. van Der WalDirk BasartJacobijne WiersmaPaulus van HaelstAntonius OomenHarry SuryapranataPieter A.M. HoogslagAlida Borger-van Der BurgMargriet Feenema-AardemaRobert BreedveldJosé Angel Garza RuízJesús Antonio Pérez RíosGuillermo Fanghänel SalmónRodrigo Suarez OteroMaría Guerrero de LeonCarlos Rodolfo Martínez SánchezGuillermo Antonio Llamas EsperónAlfredo Nacoud AckarEduardo Salcido VázquezBelinda González DíazEnrique López RosasLuis Gerardo González SalasJaime Carranza MadrigalMarco Antonio Alcocer GambaEdmundo Alfredo Bayram LlamasJuan Carlos Núñez FragosoPedro Fajardo CamposJorge Carrillo CalvilloArmando García CastilloWan Mohd Izani Wan MohamedHoung LiewBalachandran KandasamyOteh MaskonSazzli KasimTiong Kiam OngSnezana DoncovskaAleksandar KjovkaroskiNensi LozanceStojko BojovskiRaimondas KubiliusAleksandras KibarskisNerijus MisonisSigute NorkieneRimvydas SlapikasGintare SakalyteRuta JurgaitieneRoma KavaliauskieneZaneta PetrulionieneIveta SimeIveta MintaleAldis StrelnieksNatalija PontagaArija BusmaneYoungkwon KimSeung-Jea TahkTaekjong HongHae Young KimHyo-Soo KimChongjin KimSeungwoon RhaMyung Ho JeongMoo Hyun KimIn-Ho ChaeHun Sik ParkHack-Lyoung KimJung Han YoonMotomaru MasutaniKazuteru FujimotoAkira NishibeYasunori UedaKatsuhiko SatoTakuya HaraguchiKashima ItoNoriaki UtsuMasaaki UematsuToshiaki ManoRitsu TamuraHiroshi SuginoYutaka FurukawaKoichi NakaoTomohiro SakamotoToshiyuki TakahashiKenshi FujiiJunya AkoToshiro ShinkeAtsuyuki WadaYousuke KatsudaMasatoshi ShimizuYujiro OnoTomohiro KawasakiKen KozumaShinji KobaHiroyuki FujinagaAkihiro KoikeShuichi TaguchiSatoru SakagamiYasuji DoiKeiji HirookaAtsushi HirayamaToshinori HigashikataHiroki UeharaIchiro MichishitaKoichi KishiKazuo KimuraYoshiki HataYoshihiro MorinoYoshihiro TakedaKenji AndoHaruo KamiyaYuji ShimataniKazuoki DaiVittorio RaccaMaurizio FerratiniPasquale Perrone FilardiZoran OlivariAlessandro de LeoRoberto VioliniGiuseppe de LucaMichela PalvariniPiermarco PiattiMaurizio TespiliMarcello GalvaniEnrico PuccioniClaudio CavalliniSergio BertiNicoletta de CesareMarco MetraPompilio FaggianoSalvatore NovoPaolo CalabròMichelle SenniGiuseppe MusumeciAlessandro SalvioniClaudio CucciaFilippo ScaliseCarla AuguadroGiovanni LicciardelloValgimigli MarcoGabriele GuardigliRaffaella GarbelottoAnnamaria de PellegrinGiancarlo PiovaccariNizar EliasMichael LishnerEfrat WolfovitzNaveh TovMazen EliasYoseph CaracoZvi VeredDov GavishOsamah HusseinVered ZviShmuel FuchsYoseph RozenmanYonathan HasinOffer AmirMichael JonasRan KornowskiAlon MarmorMajdi HalabiYoav TurgemanRobert ZukermannEugenia NikolskyMarc KlutsteinAdi FrancisYaakov HenkinAmos KatzUri RosenscheinChaim LotanHavakuk OferChorin EhudYaron ArbelMorris MosseriMichael ShechterShaul AtarShireesh SathePriya PalimkarShireesh SaatheJabir AbdullakuttyVinay KumarSrihari DasPatil RahulRohidas BorsePrasant BhansaliShiv Kumar YerraBagirath RaghuramanAjit BhagwatSuhas KalashettiJugal GuptaRishabh MathurUlhas PandurangiChandrakant PatilSrilakshmi AdhyapakSunil ThanviSunil KarnaVengatesh MunusamySumeet SethiNitin PatkiGajendra ManaksheRituparna ShindeNaresh GoyalVijay ChopraPatil SachinAparna PatangeMahesh FulwaniManoj ChopdaJasprakash Singh GrewalShamanna IyengarAziz KhanMinguel MonteiroRamesh PothineniSrimannarayana JujjuruSanjay PorwalSantanu GuhaPankaj HarkutSanjeev ChaudharyAbhijeet JoshiJitendra SawhneyDhiman KahaliSachin PatilDhurjati SinhaAbraham OommanRavishankar GovindaPrafulla KerkarAtul AbhyanakarSudhir PawarAjaykumar MahajanRajendra PremchandReddy RegellaNaveen Reddy ProdduturSharath AnnamManjinder SandhuMukund KumblaJózsef FaluközyZsolt SzigetiTibor KapinIván HorvathGábor MüllerIstván ÉdesAndrás KatonaLajos NagyGeza LupkovicsImre UngiBela MerkelyTibor TuriDavid C.W. SiuBryan P.Y. YanEdgar Rodriguez de LeonJuan Arango BeneckeSergio Fausto OvandoApostolos HatzitoliosJohn LekakisGeorgios HahalisDimitrios AlexopoulosFrangkiskos ParthenakisPanagiotis VardasVasilios AthyrosIoannis SkoumasGeargios ChachalisDimitrios SionisAthanassios ManolisAthanasios KartalisSotiris PatsilinakosWerner RiekerHolger KillatUwe GremmlerElmar OffersLothar HeidenreichStephan SteinerDirk Müller-WielandSusanne SchmittMohammed NatourJohannes WaltenbergerHeinz VöllerJoachim WeilTim SchaeufeleMatthias WeissbrodtMichael JeserichNicole ToursarkissianRüdiger Braun-DullaeusDirk BöckerStefan LeggewieNikos WernerThomas MuenzelGregor SimonisMahir KarakasKarsten SydowSteffen BehrensBernhard WinkelmannSebastian NudingStephan GielenChristian WernerUlrich LaufsThomas HeitzerDetlev SchellenbergAndreas ZirlikRoger MarxHans Friedrich VöhringerEmmanouil LianopoulosThomas DorselChristoph StellbrinkHeyder OmranEkkehard SchmidtKarl-Friedrich AppelMatthias StratmannUrsula Rauch-KröhnertKemala EdwardRayyan HemetsbergerGeorge KhabeishviliZaza LominadzeRamaz GhlontiZurab PagavaTamaz ShaburishviliIrakli KhintibidzeBernard CitronThierry LefèvreJacques BerlandVincent ProbstVictor AboyansFrançois SchieleJérôme ClercFranck PaganelliFranck BoccaraNicolas DelarcheAbdelkader BelhassaneFlorence LeclercqYves CottinJacques MansouratiGilles Barone-RochetteJacques MachecourtGilles MontalescotOlivier MorelEmile FerrariPierre CosteHeikki HuikuriSaila VikmanJuhani AiraksinenArved KristjanTiina JurgensonKaja MärtsinÜllar SoopõldAnu HedmanVeiko VahulaMai SootsLars VidebaekFlemming DavidsenPeter Kaiser NielsenIb KlausenJens LomholdtPiotr Maria WalichiewiczKjeld KristensenTonny NielsenJørgen JeppesenPeter JohansenFlemming HaldPeter Betton JohansenJohn LarsenGunnar GislasonLars FrostJens HoveMorten BøttcherOle MayLia BangPeter ClemmensenBent RaungaardSteen PoulsenJiri MatuskaPetr PovolnyJiri KucharPetr HeincPremysl SvabIvana MarusincovaZuzana MotovskaJiri ZizkaIvo PodperaVera AdamkovaZdenek CoufalRobert NaplavaRichard RokytaVladimir KaucakVojtech NovotnyAles LinhartVilma MachovaDavid AlanJosef StasekZdenek VelickaDavid HorakJindrich SpinarBoris StarcevicStanka Mejic-KrstulovicJosip LukendaVjekoslav TomulicZdravko BabićKresimir ŠtambukDean MiletaViktor PeršićJozica ŠikićĐeiti PrvulovićHrvoje PintarićMartina Lovrić BenčićDavor MiličićMelita JerićSiniša CarMaja StrozziAngela Fernandez TrujilloMiguel Urina TrianaRafael Suarez ArambulaJeffrey Castellanos ParadaAristides Sotomayor HerazoFernando Manzur JatinAlvaro Quintero OssaRicardo Fernandez RuizJose Accini MendozaJulian Coronel ArroyoHenry Garcia LozadaSandra Barrera SilvaMarco BlanquicettJuan Diego HigueraCarlos Cotes ArocaAlberto Cadena BonfantiDora Molina de SalazarRodrigo Botero LopezDiana Luna BotiaGregorio Sanchez VallejoNicolas JaramilloChun WuTianchang LiZhongcai FanYizhou XuJianhua ZhuRuiyan ZhangQinghua LuYingxian SunMeixiang XiangJian’an WangXiangjun YangXiling ShouWeiyi FangFeng BaiGuosheng FuJunbo GeXubo ShiXiping XuYing GuoZuyi YuanXingsheng ZhaoYujie ZhouWeihong JiangBaiming QuYihua YuShaowen LiuMeng WeiXuebo LiuWeiguo LiShuiping ZhaoDaoquan PengXiaodong LiYang ZhengYi ZhongChunhua DingYundai ChenZhurong LuoZeqi ZhengZheng ZhangXuefeng LinYuannan KeXinchun YangDingli XuYi FengHuanming LiWenxia ZongJinxiu LinXiaoshu ChengXi SuBiao XuGuohai SuShaohong DongLan HuangDandan ChenHong ZhuXuelian ZhangJianping LiJingfeng WangYuemin SunWenhua LinLan CuiXiang LiZhuhua YaoShi'An HuangJianzhong WangWeijian HuangYugang DongJiyan ChenHumberto MontecinosLeonardo NahuelpanClaudia OlivaresCarlos RaffoLaura HuidobroFernando FlorenzanoPaola VarletaLuis PerezMauricio FernandezGuillermo AranedaMario YañezMargarita VejarArnoldo AguirreMonica AcevedoSergio PotthoffCristian PincettiAdnan HameedIqbal BataThao HuynhDavid ClevelandHussein FadlallahJosep Rodés-CabauSohrab LutchmedialPeter FongRobert DupuisJames ChaShamir MehtaSerge LepageJohn DucasRam VijayaraghavanGustavo NogaredaRichard DaviesFrank NigroChristopher LaiTycho VuurmansRaymond LeungDavid FellNicolas MichaudAriel DiazPaul MacdonaldSimon KouzBruce SussexEric SabbahAnne MorissetRonald BourgeoisGordon HoagSaul VizelGilbert GosselinSimon RobinsonAmritanshu PandeyYves PesantDaniel SavardDanielle DionStephen PearceJan KornderJames StoneManohara SenaratneBojidar DimovPetar LazovValentina MinchevaMaryana GospodinovRaya IvanovaKatya Ilieva-PandevaKostadin KichukovMihail MollovDimitar RaevDimitar MarkovNina Shehova-YankovaHaralin TumbevStanislav PetranovHaralambi BenovMaria TzekovaElena VelchevaFedya NikolovGeorgi TodorovJosé Carlos Aidar AyoubLeandro MachadoHelder J.L. ReisWeimar K.S.B. SouzaFernando CostaJuliana de SouzaLuiz Eduardo F. RittGilson FeitosaJose Marin-NetoWladmir SaporitoJose SilveiraPedro SilvaJose Moura JorgeDalton PrecomaEuler Roberto Fernandes ManentiSergio KaiserRoberto BotelhoPaulo LeaesMaria VidottiFreddy EliaschewitzYorghos MichalarosLuiz BodaneseFernando NeuenschwanderMayler O.N. de SantosAna Priscila SoggiaPedro Pimentel FilhoJosé Antonio M. AbrantesAdrian KormannRenato KalilNorberto DudaMaria José A.G. CerqueiraPaulo R.F. RossiRafael RechLilia Nigro MaiaRicardo SilvaFlavio GiorgetoJose NicolauLuciano SousaGilmar ReisBoris GoronjaAdis MuslibegovicDusko VulicAzra Durak-NalbanticMehmed KulićEmir FazlibegovicBelma PojskicZlatko MidzicFahir BarakovicIbrahim TerzicFrank CoolsMarc ClaeysEmanuele BarbatoJohn RoosenCarl ConvensHarry StriekwoldGeert VervoortChristophe BeauloyeKarl DujardinMarc CastadotBart WollaertLuc de WolfMathias C.M. VrolixEtienne HofferAttilio LeoneBruno PirenneKurt HermansDirk FaesFranz WeidingerBernhard FreyGeorg Delle-KarthRudolf BergerKurt HuberUta HoppeRobert ZweikerRonald DickPatrick CarrollMark SaderGregory StarmerPaul GarrahySteven G.M. CoverdaleConstantine AroneySam LehmanOwen RaffelPhilip Roberts-ThomsonRomulo Oqueli FloresDavid ColquhounJames RogersDaniel NinioJohn HorowitzMargaret ArstallJames ShawChris L.S. HiiAllan SowardNicholas CollinsJonathon WaitesSusana LloisOsvaldo CostamagnaGerardo ZapataSilvia SaavedraJorge GiordanoHugo LuquezHoracio CestariRuben Garcia DuranMario BerliGabriel WaismanHector LuciardiVictorino FuentealbaAlberto LibermanHugo ColomboEduardo D.S. BlumbergSebastian NaniMiguel Bustamante LabartaDaniela Garcia BrascaJuan Medrano AllendePablo GuzmanGabriela CarneroMarisa VicoRicardo DranMaria GiulianoCesar ZaidmanCristian PatocchiFederico NovoaRodolfo Ahuad GuerreroJulio VallejosAdrian HrabarJulio O.E. BonoHoracio JureOscar CoduttiOscar SalomoneMarcos AmuchasteguiGuillermo CaimeIgnacio MackinnonGustavo PaterliniLuis CartasegnaAlberto LorenzattiOscar Gomez VilamajoAlberto CaccavoOscar MontañaMiguel Angel HominalLeonardo NovarettoOrlando CarusoErnesto DurontoJorge SchmidbergAlberto Alves de LimaAnselmo BordonavaSonia SassoneAndrés AlvarisquetaMarcelo GarridoLilia SchiaviAndrew YanMatthew WilsonSean van DiepenCharlene TrotterMustafa TomaDarin SujjavanichKenya StringfellowMatthew SherwoodBimal ShahWilliam Schuyler JonesÉtienne PuymiratThomas PovsicLynn PerkinsSabrina Bernardez-PereiraChetan PatelHumberto Graner MoreiraRobert MentzRajendra MehtaRobin MathewsJill MarcusDavid MaronLinda LillisSergio LeonardiDavid KongBradley KollsJoshua KnowlesJoseph Dedrick JordanMark HlatkyConnie Ng HessRobert HarrisonArleen EppingerPatricia EndsleyZubin EapenGrégory DucrocqKeith DombrowskiSheila DickeyShalonda DeloatchAdam DevoreShaun CliftonJ. Matthew BrennanMaria Cecilia BahitAkshay BagaiLuciana ArmaganijanJohn AlexanderEric J.G. SijbrandsRobert RosensonChiara MeloniKaren AlexanderMaarten SimoonsJean-Lucien RouleauAnders OlssonSheryl KelseyBernard ChaitmanRobert VogelPatrick MoriartyKausik RayAlexander ParkhomenkoSema GuneriPiyamitr SritaraChern-En ChiangUlf LandmesserEmil HagströmH. Asita de SilvaJosé TuñónAnthony DalbyZlatko FrasJan MurinTerrance ChuaArsen RisticYuri KarpovMaria DorobantuJoao MoraisAndrzej BudajRoger Correa FloresSigrun HalvorsenMarco AlingsGabriel Arturo Ramos LópezKhalid YusoffSasko KedevAleksandras LauceviciusAndrejs ErglisSang-Hyun KimHyo Soo KimTakeshi KimuraMarco ValgimigliDoron ZahgerDenis XavierRobert Gabor KissHung-Fat TsePablo Carlos Montenegro ValdovinosEvangelos LiberopoulosNicolas DanchinNikolaus MarxVakhtang ChumburidzeMarkku NieminenMargus ViigimaaPetr OstadalZeljko ReinerIvan PećinPatricio López-JaramilloHuo YongJuan-Carlos PrietoNina GotchevaRenato LopesMirza DilicPeter SinnaeveHeinz DrexelPhilip AylwardJean-François TambyWilliam SasielaAngèle MoryusefGuillaume LecorpsCorinne HanotinJay EdelbergKenneth MahaffeyMatthew RoePierluigi TricociAndreas ZeiherRobert HarringtonJ. Wouter JukemaPhilippe Gabriel StegHarvey WhiteRobert PordyGaren ManvelianMegan LoyJ Wouter JukemaShaun GoodmanRafael DiazDeepak BhattVera BittnerMichael SzarekGregory Schwartz
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Auckland City Hospital Regeneron Pharmaceuticals [Tarrytown, NY] Regeneron Pharmaceuticals [Tarrytown, NY] Sanofi Bridgewater Leiden University Medical Center [Leiden] University of Alberta St. Michael's Hospital ECLAEstudios Clínicos Latino América & Instituto Cardiovascular de Rosario), Rosario, Argentina Brigham & Women’s Hospital [Boston] University of Alabama [Birmingham] University of Colorado Anschutz Medical Campus [Aurora] Clinical Research Center State University of New York University of Colorado Anschutz Medical Campus [Aurora]
• Publié dans Diabetes Care le 01/11/2020

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Résumé : OBJECTIVE In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary syndrome. Incident diabetes was determined from laboratory, medication, and adverse event data. RESULTS Among 13,480 patients without diabetes at baseline, 1,324 developed type 2 diabetes over a median 2.7 years. Median baseline lipoprotein(a) was 21.9 mg/dL. With placebo, 10 mg/dL lower baseline lipoprotein(a) was associated with hazard ratio 1.04 (95% CI 1.02−1.06, P < 0.001) for incident type 2 diabetes. Alirocumab reduced lipoprotein(a) by a median 23.2% with greater absolute reductions from higher baseline levels and no overall effect on incident type 2 diabetes (hazard ratio 0.95, 95% CI 0.85–1.05). At low baseline lipoprotein(a) levels, alirocumab tended to reduce incident type 2 diabetes, while at high baseline lipoprotein(a) alirocumab tended to increase incident type 2 diabetes compared with placebo (treatment–baseline lipoprotein(a) interaction P = 0.006). In the alirocumab group, a 10 mg/dL decrease in lipoprotein(a) from baseline was associated with hazard ratio 1.07 (95% CI 1.03−1.12; P = 0.0002) for incident type 2 diabetes. CONCLUSIONS In patients with acute coronary syndrome, baseline lipoprotein(a) concentration associated inversely with incident type 2 diabetes. Alirocumab had neutral overall effect on incident type 2 diabetes. However, treatment-related reductions in lipoprotein(a), more pronounced from high baseline levels, were associated with increased risk of incident type 2 diabetes. Whether these findings pertain to other therapies that reduce lipoprotein(a) is undetermined.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Vincent ProbstThomas GoronflotSoraya AnysRomain TixierJean BriandPauline BerthomeOlivier GeoffroyNicolas ClementyJacques MansouratiLaurence Jesel-MorelJean-Marc DupuisPaul BruFlorence KyndtMatthieu WargnyBéatrice GuyomarchAurélie TholletPhilippe MaboPierre-Antoine GourraudNathalie BeharFrédéric SacherJean-Baptiste Gourraud
• Organismes : Optimisation des régulations physiologiques Hôpital de la Cavale Blanche - CHRU Brest Nanomédecine Régénérative
• Publié dans European Heart Journal le 30/10/2020

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Résumé : AIMS: Risk stratification of sudden cardiac arrest (SCA) in Brugada syndrome (Brs) remains the main challenge for physicians. Several scores have been suggested to improve risk stratification but never replicated. We aim to investigate the accuracy of the Brs risk scores. METHODS AND RESULTS: A total of 1613 patients [mean age 45 ± 15 years, 69% male, 323 (20%) symptomatic] were prospectively enrolled from 1993 to 2016 in a multicentric database. All data described in the risk score were double reviewed for the study. Among them, all patients were evaluated with Shanghai score and 461 (29%) with Sieira score. After a mean follow-up of 6.5 ± 4.7 years, an arrhythmic event occurred in 75 (5%) patients including 16 SCA, 11 symptomatic ventricular arrhythmia, and 48 appropriate therapies. Predictive capacity of the Shanghai score (n = 1613) and the Sieira (n = 461) score was, respectively, estimated by an area under the curve of 0.73 (0.67-0.79) and 0.71 (0.61-0.81). Considering Sieira score, the event rate at 10 years was significantly higher with a score of 5 (26.4%) than with a score of 0 (0.9%) or 1 (1.1%) (P < 0.01). No statistical difference was found in intermediate-risk patients (score 2-4). The Shanghai score does not allow to better stratify the risk of SCA. CONCLUSIONS: In the largest cohort of Brs patient ever described, risk scores do not allow stratifying the risk of arrhythmic event in intermediate-risk patient.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Romain GarreauRomain BriccaMarie-Claude GagnieuSandrine RouxAnne ConradLaurent BourguignonTristan FerrySylvain GoutelleFlorent ValourThomas PerpointPatrick MiailhesFlorence AderAgathe BeckerClaire Triffault-FillitCécile PouderouxNicolas BenechPierre ChauvelotMarielle PerryFatiha DaoudJohanna LippmanEvelyne BraunChristian ChidiacElvire ServienSébastien LustigCécile BataillerStanislas GunstAxel SchmidtMatthieu MalatrayElliot Sappey-MarinierMichel-Henry FessyAnthony VisteJean-Luc BessePhilippe ChaudierLucie LouboutinQuentin OdeAdrien van HaeckeMarcelle MercierVincent BelgaidArnaud WalchSébastien MartresFranck TrouilletCédric BarreyAli MojallalSophie BrossetCamille HanriatHélène PersonNicolas SigauxPhilippe CéruseCarine FuchsmannFrédéric AubrunMikhail DziadzkoCaroline MacabéoFrederic LaurentLaetitia BeraudTiphaine Roussel-GaillardCéline DupieuxCamille KolendaJérôme JosseMarie BrevetAlexis TrecourtFabien CraigheroL. BousselJean-Baptiste PialatIsabelle MorelecMichel TodEugénie Mabrut
• Organismes : Hospices Civils de Lyon Lyon Bone and Joint Infection Study Group Hôpital Nord-Ouest [Villefranche sur Saône] Lyon Bone and Joint Infection Study Group Hospices Civils de Lyon Lyon Bone and Joint Infection Study Group Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Centre de référence des infections ostéo-articulaires complexes Rhône Alpes Auvergne Lyon Bone and Joint Infection Study Group Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Centre de référence des infections ostéo-articulaires complexes Rhône Alpes Auvergne Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques Lyon Bone and Joint Infection Study Group Hospices Civils de Lyon Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Lyon Bone and Joint Infection Study Group Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Centre de référence des infections ostéo-articulaires complexes Rhône Alpes Auvergne Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques Centre International de Recherche en Infectiologie Lyon Bone and Joint Infection Study Group Hospices Civils de Lyon Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Laboratoire de Biomécanique et Mécanique des Chocs Lyon Bone and Joint Infection Study Group Laboratoire de Biomécanique et Mécanique des Chocs Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Laboratoire de Biomécanique et Mécanique des Chocs Lyon Bone and Joint Infection Study Group Laboratoire de Biomécanique et Mécanique des Chocs Lyon Bone and Joint Infection Study Group Laboratoire de Biomécanique et Mécanique des Chocs Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis Lyon Bone and Joint Infection Study Group Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group Lyon Bone and Joint Infection Study Group
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Background Daptomycin is increasingly used in the treatment of bone and joint infection (BJI), but its pharmacokinetics (PK) and dosage requirements have not been thoroughly investigated in this indication. Daptomycin may be co-administered with rifampicin, which raises questions about a potential drug interaction. Objectives To investigate the population PK and dosage requirements of daptomycin in patients with BJI, and examine the influence of rifampicin co-administration. Methods A population approach was used to analyse PK data from patients who received daptomycin in our regional reference for BJI. We examined the influence of available covariates, including rifampicin co-administration on daptomycin PK. Simulations performed with the final model investigated the influence of dosages and covariates on PTA for both efficacy and safety. Results A total of 1303 daptomycin concentrations from 183 patients were analysed. A two-compartment model best described the data. Significant intra-individual variability was observed. Daptomycin clearance was influenced by renal function and sex, with females having a 26% lower typical clearance than males. Central volume of distribution (V1) was influenced by body weight, age, sex and rifampicin co-administration. Typical V1 was 11% lower in patients who were co-administered rifampicin. In PK/PD simulations, sex influenced the probability of AUC24/MIC target attainment, while rifampicin had a marginal effect. Conclusions A daptomycin dosage of 8 mg/kg/24 h in women and 10 mg/kg/24 h in men should optimize efficacy but may lead to excessive trough concentrations in many patients, especially in women. Therapeutic drug monitoring appears necessary for precision dosing of daptomycin.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Yuanwei QinXiangming XiaoWigneron J.-P.Philippe CiaisMartin BrandtSassan S SaatchiXiaojun LiSean CrowellXiaocui WuRussell DoughtyYao ZhangFang LiuStephen SitchBerrien Moore
• Organismes : University of Oklahoma University of Oklahoma Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC University of Copenhagen = Københavns Universitet Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère University of Oklahoma University of Oklahoma University of Oklahoma Lawrence Berkeley National Laboratory [Berkeley] Chinese Academy of Sciences [Beijing] University of Exeter University of Oklahoma
• Publié dans Nature Climate Change le 30/10/2020

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Résumé : Spatial–temporal dynamics of aboveground biomass (AGB) and forest area affect the carbon cycle, climate and biodiversity in the Brazilian Amazon. Here we investigate interannual changes in AGB and forest area by analysing satellite-based annual AGB and forest area datasets. We found that the gross forest area loss was larger in 2019 than in 2015, possibly due to recent loosening of forest protection policies. However, the net AGB loss was three times smaller in 2019 than in 2015. During 2010–2019, the Brazilian Amazon had a cumulative gross loss of 4.45 Pg C against a gross gain of 3.78 Pg C, resulting in a net AGB loss of 0.67 Pg C. Forest degradation (73%) contributed three times more to the gross AGB loss than deforestation (27%), given that the areal extent of degradation exceeds that of deforestation. This indicates that forest degradation has become the largest process driving carbon loss and should become a higher policy priority.

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Fichiers liés : s41558-021-01026-5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Ronan RousselPatrice DarmonMatthieu PichelinThomas GoronflotYawa AboulekaLeila Ait BachirIngrid AllixDeborah AncelleSara BarraudLyse BordierAurélie CarlierNicolas ChevalierChristine Coffin‐boutreuxEmmanuel CossonAnne DorangeOlivier DupuyPierre FontaineBénédicte FremyFlorence GaltierNatacha GermainAnne‐marie GuedjEtienne LargerStéphanie Laugier‐robiolleBruno LaviolleLisa LudwigArnaud MonierNathanaëlle MontanierPhilippe MoulinIsabelle MouraGaëtan PrevostYves ReznikNadia SabbahPierre-Jean SaulnierPierre SerusclatCamille VatierMatthieu WargnySamy HadjadjPierre GourdyBertrand Cariou
• Organismes : Centre de Recherche des Cordeliers Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] Aix Marseille Université Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Centre de Recherche des Cordeliers Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] CHU d'Angers [Département Urgences] Centre Hospitalier Universitaire d'Angers Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 Hôpital d'Instruction des Armées Begin [Saint-Mandé, France] Centre de Recherche des Cordeliers Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] Centre méditerranéen de médecine moléculaire Unité de Recherche en Epidémiologie Nutritionnelle Centre Hospitalier Le Mans (CH Le Mans) Centre hospitalier Saint-Joseph [Paris] Hôpital Claude Huriez [Lille] CIC Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire de Nîmes Service de diabétologie [CHU Cochin] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Nancy Hôpitaux de Chartres [Chartres] Cardiovasculaire, métabolisme, diabétologie et nutrition Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen] Différenciation et communication neuronale et neuroendocrine Service Endocrinologie - Diabétologie [CHU Caen] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre de Recherche Saint-Antoine ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut des Maladies Métaboliques et Cardiovasculaires ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Diabetes, Obesity and Metabolism le 01/11/2020

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Résumé : Aim: To investigate the association between routine use of dipeptidyl peptidase-4 (DPP-4) inhibitors and the severity of coronavirus disease 2019 (COVID-19) infection in patient with type 2 diabetes in a large multicentric study. Materials and Methods: This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID-19 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilation and death within 7 days of admission. Stabilized weights were computed for patients based on propensity score (DPP-4 inhibitors users vs. non-users) and were used in multivariable logistic regression models to estimate the average treatment effect in the treated as inverse probability of treatment weighting (IPTW). Results: Five hundred and ninety-six participants were under DPP-4 inhibitors before admission to hospital (24.3%). The primary outcome occurred at similar rates in users and non-users of DPP-4 inhibitors (27.7% vs. 28.6%; p = .68). In propensity analysis, the IPTW-adjusted models showed no significant association between the use of DPP-4 inhibitors and the primary outcome by Day 7 (OR [95% CI]: 0.95 [0.77-1.17]) or Day 28 (OR [95% CI]: 0.96 [0.78-1.17]). Similar neutral findings were found between use of DPP-4 inhibitors and the risk of tracheal intubation and death. Conclusions: These data support the safety of DPP-4 inhibitors for diabetes management during the COVID-19 pandemic and they should not be discontinued.

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Fichiers liés : Roussel et al-2021-Use of Dipeptidyl Peptidase-4 inhibitors and prognosis of COVID-19 in.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/05/2021
• Auteurs : Jean-François SilvainRobin GoffauxHélène SoubeletFrancois SarrazinLuc AbbadieCécile H. AlbertSamuel AlizonIsabelle ArpinSébastien BarotDaniel BarthélémyDidier BazilePhilippe BilletCéline BoudetNathalie CharbonnelAnne CharmantierGauthier DobignyLaure EmperaireSabrina GabaPhilippe GaubertEmmanuelle Gilot-FromontPhilippe GrandcolasJean-François GuéganHervé JactelYann LauransVincent LeblanLine Le GallHarold LevrelSerge MorandJean-Louis MorelFrançois MoutouJean-Louis PhamOlivier PlantardDominique PontierBenjamin RocheFrançois RogerGuillaume SaintenyPierre ScemamaSamuel SoubeyrandEric ThybaudMarion VittecoqGwenaël Vourc’h
• Organismes : Fondation pour la recherche sur la Biodiversité Fondation pour la recherche sur la Biodiversité Fondation pour la recherche sur la Biodiversité Sorbonne Université Sorbonne Université Centre National de la Recherche Scientifique Laboratoire des EcoSystèmes et des Sociétés en Montagne Institut de Recherche pour le Développement Direction Générale Déléguée à la Recherche et à la Stratégie Gestion des ressources renouvelables et environnement Département Environnements et Sociétés Université Jean Moulin Lyon 3 - Faculté de Droit Institut National de l'Environnement Industriel et des Risques Centre de Biologie pour la Gestion des Populations Centre National de la Recherche Scientifique Institut Ecologie et Environnement - CNRS Ecologie et Environnement Institut de Recherche pour le Développement Institut de Recherche pour le Développement Centre d'Études Biologiques de Chizé - UMR 7372 Institut de Recherche pour le Développement Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Institut de Systématique, Evolution, Biodiversité Institut de Recherche pour le Développement Biodiversité, Gènes & Communautés Institut du Développement Durable et des Relations Internationales Institut de Recherche pour le Développement Institut de Systématique, Evolution, Biodiversité Centre International de Recherche sur l'Environnement et le Développement Centre National de la Recherche Scientifique Institut Ecologie et Environnement - CNRS Ecologie et Environnement Laboratoire Sols et Environnement Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Retraité Institut de Recherche pour le Développement Biologie, Epidémiologie et analyse de risque en Santé Animale Université Claude Bernard Lyon 1 Institut de Recherche pour le Développement Animal, Santé, Territoires, Risques et Ecosystèmes Fondation pour la recherche sur la Biodiversité Institut Français de Recherche pour l'Exploitation de la Mer Biostatistique et Processus Spatiaux Institut National de l'Environnement Industriel et des Risques Institut de recherche de la Tour du Valat Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques

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Résumé : L’épidémie COVID-19 pose de nombreuses questions. Quels sont les liens de cette crise sanitaire avec la faune sauvage, quels sont ses liens avec l’érosion de la biodiversité que le dernier rapport de l’Ipbes a souligné, quels sont ses liens avec certains systèmes de production alimentaire et plus généralement avec l’anthropisation de la planète ? Pour les éclairer sur ces sujets, les pouvoirs publics se sont tournés vers la recherche.

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Fichiers liés : Mobilisation-FRB-Covid-19-06-2021-Ok-FR.pdf

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